Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RCOR1 Gene

Aliases for RCOR1 Gene

  • REST Corepressor 1 2 3
  • RCOR 3 4 6
  • KIAA0071 4 6
  • COREST 3 6
  • REST Corepressor 2
  • Protein CoREST 4

External Ids for RCOR1 Gene

Previous HGNC Symbols for RCOR1 Gene

  • RCOR

Previous GeneCards Identifiers for RCOR1 Gene

  • GC14P101050
  • GC14P102128
  • GC14P103059
  • GC14P083236

Summaries for RCOR1 Gene

Entrez Gene Summary for RCOR1 Gene

  • This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

GeneCards Summary for RCOR1 Gene

RCOR1 (REST Corepressor 1) is a Protein Coding gene. Among its related pathways are Hemostasis and fMLP Pathway. GO annotations related to this gene include chromatin binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is RCOR3.

UniProtKB/Swiss-Prot for RCOR1 Gene

  • Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Gene Wiki entry for RCOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR1 Gene

Genomics for RCOR1 Gene

Regulatory Elements for RCOR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RCOR1 Gene

Start:
102,592,659 bp from pter
End:
102,730,576 bp from pter
Size:
137,918 bases
Orientation:
Plus strand

Genomic View for RCOR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR1 Gene

Proteins for RCOR1 Gene

  • Protein details for RCOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKL0-RCOR1_HUMAN
    Recommended name:
    REST corepressor 1
    Protein Accession:
    Q9UKL0
    Secondary Accessions:
    • Q15044
    • Q6P2I9
    • Q86VG5

    Protein attributes for RCOR1 Gene

    Size:
    482 amino acids
    Molecular mass:
    53028 Da
    Quaternary structure:
    • Interacts directly with GFI1 and GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1 (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF complex. Interacts with herpes virus HSV-1 ICP0 protein; the interaction leads to the disruption of the BHC complex, thereby preventing the BHC complex from repressing transcription of viral genes.
    SequenceCaution:
    • Sequence=AAH64495.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCOR1 Gene

neXtProt entry for RCOR1 Gene

Proteomics data for RCOR1 Gene at MOPED

Post-translational modifications for RCOR1 Gene

Other Protein References for RCOR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RCOR1 (RCOR1)

No data available for DME Specific Peptides for RCOR1 Gene

Domains for RCOR1 Gene

Protein Domains for RCOR1 Gene

Suggested Antigen Peptide Sequences for RCOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKL0

UniProtKB/Swiss-Prot:

RCOR1_HUMAN :
  • Q9UKL0
Domain:
  • The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A.
  • Contains 1 ELM2 domain.
  • Contains 2 SANT domains.
Family:
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR1: view

No data available for Gene Families for RCOR1 Gene

Function for RCOR1 Gene

Molecular function for RCOR1 Gene

UniProtKB/Swiss-Prot Function: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Gene Ontology (GO) - Molecular Function for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 10449787
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 10449787
GO:0044212 transcription regulatory region DNA binding IDA 17555596
genes like me logo Genes that share ontologies with RCOR1: view

Phenotypes for RCOR1 Gene

MGI mutant phenotypes for RCOR1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RCOR1: view

Animal Model Products

CRISPR Products

miRNA for RCOR1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCOR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RCOR1 Gene

Localization for RCOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR1 Gene

Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCOR1 Gene COMPARTMENTS Subcellular localization image for RCOR1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10449787
GO:0005654 nucleoplasm TAS --
GO:0017053 transcriptional repressor complex IDA 10734093
genes like me logo Genes that share ontologies with RCOR1: view

Pathways for RCOR1 Gene

genes like me logo Genes that share pathways with RCOR1: view

Pathways by source for RCOR1 Gene

1 Qiagen pathway for RCOR1 Gene
1 KEGG pathway for RCOR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10449787
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0007596 blood coagulation TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with RCOR1: view

Compounds for RCOR1 Gene

(1) Novoseek inferred chemical compound relationships for RCOR1 Gene

Compound -log(P) Hits PubMed IDs
zinc 15.4 1
genes like me logo Genes that share compounds with RCOR1: view

Transcripts for RCOR1 Gene

mRNA/cDNA for RCOR1 Gene

Unigene Clusters for RCOR1 Gene

REST corepressor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCOR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR1 Gene

No ASD Table

Relevant External Links for RCOR1 Gene

GeneLoc Exon Structure for
RCOR1
ECgene alternative splicing isoforms for
RCOR1

Expression for RCOR1 Gene

mRNA expression in normal human tissues for RCOR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RCOR1 Gene

SOURCE GeneReport for Unigene cluster for RCOR1 Gene Hs.510521

mRNA Expression by UniProt/SwissProt for RCOR1 Gene

Q9UKL0-RCOR1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with RCOR1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RCOR1 Gene

Orthologs for RCOR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCOR1 35
  • 97.44 (n)
  • 96.27 (a)
RCOR1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RCOR1 35
  • 91.81 (n)
  • 96.86 (a)
RCOR1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCOR1 35
  • 93.12 (n)
  • 98.23 (a)
RCOR1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcor1 35
  • 88.63 (n)
  • 96.33 (a)
Rcor1 16
Rcor1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RCOR1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC102554884 35
  • 86.61 (n)
  • 94.23 (a)
chicken
(Gallus gallus)
Aves RCOR1 35
  • 84.2 (n)
  • 95.34 (a)
RCOR1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCOR1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor1 35
  • 76.8 (n)
  • 83.29 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6894 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17938 35
rcor1 35
  • 68.31 (n)
  • 74.35 (a)
rcor1 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002488 35
  • 54.75 (n)
  • 52.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoRest 35
  • 55.37 (n)
  • 50.5 (a)
CoRest 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rcor-1 36
  • 15 (a)
ManyToMany
spr-1 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12954 35
Species with no ortholog for RCOR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR1 Gene

ENSEMBL:
Gene Tree for RCOR1 (if available)
TreeFam:
Gene Tree for RCOR1 (if available)

Paralogs for RCOR1 Gene

Paralogs for RCOR1 Gene

Selected SIMAP similar genes for RCOR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RCOR1 Gene

genes like me logo Genes that share paralogs with RCOR1: view

Variants for RCOR1 Gene

Sequence variations from dbSNP and Humsavar for RCOR1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs6611 -- 102,729,513(+) TTTTT(G/T)ATTGT utr-variant-3-prime
rs20485 -- 102,594,269(+) AGCAT(C/T)TTGTA intron-variant
rs714827 -- 102,647,215(-) acttg(C/T)ttcca intron-variant
rs734569 -- 102,667,454(+) tgaca(C/T)ggtac intron-variant
rs749542 -- 102,590,943(-) CTGTG(C/T)GAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RCOR1 Gene

Variant ID Type Subtype PubMed ID
nsv832880 CNV Loss 17160897
dgv263n27 CNV Gain 19166990
nsv902255 CNV Loss 21882294
nsv1430 CNV Insertion 18451855
nsv7257 OTHER Inversion 18451855
nsv516226 CNV Loss 19592680
nsv512377 CNV Loss 21212237
esv2663482 CNV Deletion 23128226
esv26391 CNV Loss 19812545
esv25323 CNV Gain 19812545
esv2670597 CNV Deletion 23128226
nsv902258 CNV Gain 21882294

Relevant External Links for RCOR1 Gene

HapMap Linkage Disequilibrium report
RCOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR1 Gene

Disorders for RCOR1 Gene

(1) University of Copenhagen DISEASES for RCOR1 Gene

genes like me logo Genes that share disorders with RCOR1: view

No data available for UniProtKB/Swiss-Prot for RCOR1 Gene

Publications for RCOR1 Gene

  1. CoREST: a functional corepressor required for regulation of neural- specific gene expression. (PMID: 10449787) Andres M.E. … Mandel G. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. CoREST is an integral component of the CoREST-human histone deacetylase complex. (PMID: 11171972) You A. … Schreiber S.L. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  3. Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. (PMID: 15897453) Gu H. … Roizman B. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  4. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. (PMID: 16079794) Lee M.G. … Shiekhattar R. (Nature 2005) 3 4 23
  5. Regulation of LSD1 histone demethylase activity by its associated factors. (PMID: 16140033) Shi Y.-J. … Shi Y. (Mol. Cell 2005) 3 4 23

Products for RCOR1 Gene

Sources for RCOR1 Gene

Back to Top

Content