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Aliases for RCOR1 Gene

Aliases for RCOR1 Gene

  • REST Corepressor 1 2 3 5
  • RCOR 3 4
  • REST Corepressor 2
  • Protein CoREST 4
  • KIAA0071 4
  • COREST 3

External Ids for RCOR1 Gene

Previous HGNC Symbols for RCOR1 Gene

  • RCOR

Previous GeneCards Identifiers for RCOR1 Gene

  • GC14P101050
  • GC14P102128
  • GC14P103059
  • GC14P083236

Summaries for RCOR1 Gene

Entrez Gene Summary for RCOR1 Gene

  • This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

GeneCards Summary for RCOR1 Gene

RCOR1 (REST Corepressor 1) is a Protein Coding gene. Diseases associated with RCOR1 include Huntington Disease. Among its related pathways are Factors involved in megakaryocyte development and platelet production and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include chromatin binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is RCOR3.

UniProtKB/Swiss-Prot for RCOR1 Gene

  • Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Gene Wiki entry for RCOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR1 Gene

Genomics for RCOR1 Gene

Regulatory Elements for RCOR1 Gene

Enhancers for RCOR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F102522 1.8 FANTOM5 Ensembl ENCODE 26.3 -66.5 -66546 6.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RCOR1 TECPR2 RPL23AP11 MOK ANKRD9 TRAF3 DIO3 ENSG00000271780 RNU6-244P DIO3OS
GH14F102315 1.4 Ensembl ENCODE 21.9 -272.8 -272849 7.7 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 RCOR1 CINP TECPR2 RPL26P4 ZNF839 CDC42BPB ENSG00000258959 ENSG00000259515 ENSG00000271780 GC14P102747
GH14F102554 1.1 Ensembl ENCODE 25.3 -37.1 -37139 1.8 CTCF KLF1 MAX INSM2 ZNF223 FEZF1 ZIC2 ZNF335 GLIS2 POLR2A RCOR1 LOC105370681 RN7SL546P
GH14F102530 1.5 FANTOM5 Ensembl ENCODE 17.8 -61.1 -61102 2.7 TBP NFXL1 RFX5 ZNF143 RCOR1 FOS SMARCA5 CEBPB USF2 RCOR2 ANKRD9 RCOR1 TRAF3 MIR4309 LOC105370680
GH14F102642 1.3 Ensembl ENCODE 20 +52.4 52362 4.8 HDGF PKNOX1 ATF1 ARNT SIN3A GLIS2 GATA2 FOS MCM3 NFYC RCOR1 TRAF3 GC14P102743
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RCOR1 on UCSC Golden Path with GeneCards custom track

Promoters for RCOR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000652750 461 3801 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 FOS ZNF548

Genomic Location for RCOR1 Gene

Chromosome:
14
Start:
102,592,639 bp from pter
End:
102,730,576 bp from pter
Size:
137,938 bases
Orientation:
Plus strand

Genomic View for RCOR1 Gene

Genes around RCOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR1 Gene

Proteins for RCOR1 Gene

  • Protein details for RCOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKL0-RCOR1_HUMAN
    Recommended name:
    REST corepressor 1
    Protein Accession:
    Q9UKL0
    Secondary Accessions:
    • Q15044
    • Q6P2I9
    • Q86VG5

    Protein attributes for RCOR1 Gene

    Size:
    482 amino acids
    Molecular mass:
    53028 Da
    Quaternary structure:
    • Interacts directly with GFI1 and GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1 (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF complex. Interacts with herpes virus HSV-1 ICP0 protein; the interaction leads to the disruption of the BHC complex, thereby preventing the BHC complex from repressing transcription of viral genes.
    SequenceCaution:
    • Sequence=AAH64495.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCOR1 Gene

neXtProt entry for RCOR1 Gene

Post-translational modifications for RCOR1 Gene

Other Protein References for RCOR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RCOR1 (RCOR1)

No data available for DME Specific Peptides for RCOR1 Gene

Domains & Families for RCOR1 Gene

Gene Families for RCOR1 Gene

Protein Domains for RCOR1 Gene

Suggested Antigen Peptide Sequences for RCOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKL0

UniProtKB/Swiss-Prot:

RCOR1_HUMAN :
  • The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A.
  • Belongs to the CoREST family.
Domain:
  • The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A.
  • Contains 1 ELM2 domain.
  • Contains 2 SANT domains.
Family:
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR1: view

Function for RCOR1 Gene

Molecular function for RCOR1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Gene Ontology (GO) - Molecular Function for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10449787
GO:0003714 transcription corepressor activity IBA --
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 10449787
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with RCOR1: view
genes like me logo Genes that share phenotypes with RCOR1: view

Animal Models for RCOR1 Gene

MGI Knock Outs for RCOR1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCOR1 Gene

Localization for RCOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR1 Gene

Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCOR1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 10449787
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IBA --
GO:0017053 transcriptional repressor complex IDA 10734093
GO:1990391 DNA repair complex IDA 24217620
genes like me logo Genes that share ontologies with RCOR1: view

Pathways & Interactions for RCOR1 Gene

genes like me logo Genes that share pathways with RCOR1: view

Pathways by source for RCOR1 Gene

Gene Ontology (GO) - Biological Process for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007596 blood coagulation TAS --
GO:0016032 viral process IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 10449787
genes like me logo Genes that share ontologies with RCOR1: view

No data available for SIGNOR curated interactions for RCOR1 Gene

Drugs & Compounds for RCOR1 Gene

(1) Drugs for RCOR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RCOR1: view

Transcripts for RCOR1 Gene

Unigene Clusters for RCOR1 Gene

REST corepressor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR1 Gene

No ASD Table

Relevant External Links for RCOR1 Gene

GeneLoc Exon Structure for
RCOR1
ECgene alternative splicing isoforms for
RCOR1

Expression for RCOR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RCOR1 Gene

Protein differential expression in normal tissues from HIPED for RCOR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2), Testis (8.1), and Lung (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RCOR1 Gene



Protein tissue co-expression partners for RCOR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RCOR1 Gene:

RCOR1

SOURCE GeneReport for Unigene cluster for RCOR1 Gene:

Hs.510521

mRNA Expression by UniProt/SwissProt for RCOR1 Gene:

Q9UKL0-RCOR1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with RCOR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RCOR1 Gene

Orthologs for RCOR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCOR1 34 35
  • 97.44 (n)
dog
(Canis familiaris)
Mammalia RCOR1 34 35
  • 93.12 (n)
cow
(Bos Taurus)
Mammalia RCOR1 34 35
  • 91.81 (n)
mouse
(Mus musculus)
Mammalia Rcor1 34 16 35
  • 88.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC102554884 34
  • 86.61 (n)
oppossum
(Monodelphis domestica)
Mammalia RCOR1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RCOR1 34 35
  • 84.2 (n)
lizard
(Anolis carolinensis)
Reptilia RCOR1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor1 34
  • 76.8 (n)
zebrafish
(Danio rerio)
Actinopterygii rcor1 34 35
  • 68.31 (n)
Dr.17938 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6894 34
fruit fly
(Drosophila melanogaster)
Insecta CoRest 34 35
  • 55.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002488 34
  • 54.75 (n)
worm
(Caenorhabditis elegans)
Secernentea rcor-1 35
  • 15 (a)
ManyToMany
spr-1 35
  • 15 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12954 34
Species where no ortholog for RCOR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR1 Gene

ENSEMBL:
Gene Tree for RCOR1 (if available)
TreeFam:
Gene Tree for RCOR1 (if available)

Paralogs for RCOR1 Gene

Paralogs for RCOR1 Gene

(2) SIMAP similar genes for RCOR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RCOR1 Gene

genes like me logo Genes that share paralogs with RCOR1: view

Variants for RCOR1 Gene

Sequence variations from dbSNP and Humsavar for RCOR1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10129838 -- 102,687,980(+) TTTTT(C/T)TTTGA intron-variant
rs10131189 -- 102,625,103(+) ctcct(C/G)acctc intron-variant
rs10131333 -- 102,625,042(+) aaaaa(A/G)aaaaa intron-variant
rs10132160 -- 102,591,686(+) CCGAA(A/G)GAAGT upstream-variant-2KB
rs10137079 -- 102,669,555(+) ccacc(A/C/G)actct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCOR1 Gene

Variant ID Type Subtype PubMed ID
nsv974373 CNV duplication 23825009
nsv832880 CNV loss 17160897
nsv7257 OTHER inversion 18451855
nsv516226 CNV loss 19592680
nsv512377 CNV loss 21212237
nsv1430 CNV insertion 18451855
nsv1136183 CNV deletion 24896259
nsv1118294 CNV deletion 24896259
nsv1049544 CNV gain 25217958
nsv1046125 CNV gain 25217958
nsv1044276 CNV gain 25217958
esv3635566 CNV loss 21293372
esv3635565 CNV loss 21293372
esv3635564 CNV loss 21293372
esv3635563 CNV loss 21293372
esv3552084 CNV deletion 23714750
esv3552083 CNV deletion 23714750
esv2670597 CNV deletion 23128226
esv2663482 CNV deletion 23128226
esv26391 CNV loss 19812545
esv25323 CNV gain 19812545
dgv263n27 CNV gain 19166990

Variation tolerance for RCOR1 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCOR1 Gene

Human Gene Mutation Database (HGMD)
RCOR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RCOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR1 Gene

Disorders for RCOR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RCOR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • congenital anomalies of kidney and urinary tract 2
- elite association - COSMIC cancer census association via MalaCards
Search RCOR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RCOR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCOR1
genes like me logo Genes that share disorders with RCOR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RCOR1 Gene

Publications for RCOR1 Gene

  1. CoREST: a functional corepressor required for regulation of neural- specific gene expression. (PMID: 10449787) Andres M.E. … Mandel G. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 22 64
  2. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. (PMID: 16885027) Yang M. … Yu H. (Mol. Cell 2006) 3 4 22 64
  3. Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. (PMID: 15897453) Gu H. … Roizman B. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 64
  4. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. (PMID: 16079794) Lee M.G. … Shiekhattar R. (Nature 2005) 3 4 22 64
  5. Regulation of LSD1 histone demethylase activity by its associated factors. (PMID: 16140033) Shi Y.-J. … Shi Y. (Mol. Cell 2005) 3 4 22 64

Products for RCOR1 Gene

Sources for RCOR1 Gene

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