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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCOR1 Gene

protein-coding   GIFtS: 60
GCID: GC14P103059

REST Corepressor 1

(Previous name: REST corepressor)
(Previous symbol: RCOR)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
REST Corepressor 11 2
RCOR1 2 3 5
COREST2 5
KIAA00713 5
REST Corepressor1
Protein CoREST3

External Ids:    HGNC: 174411   Entrez Gene: 231862   Ensembl: ENSG000000899027   OMIM: 6076755   UniProtKB: Q9UKL03   

Export aliases for RCOR1 gene to outside databases

Previous GC identifers: GC14P101050 GC14P102128 GC14P083236


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCOR1 Gene:
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in
determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor
element-1 silencing transcription factor). (provided by RefSeq, Aug 2011)

GeneCards Summary for RCOR1 Gene: 
RCOR1 (REST corepressor 1) is a protein-coding gene. Diseases associated with RCOR1 include fg syndrome, and herpes simplex, and among its related super-pathways are Parkinson's disease and Platelet activation, signaling and aggregation. GO annotations related to this gene include chromatin binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is RCOR2.

UniProtKB/Swiss-Prot: RCOR1_HUMAN, Q9UKL0
Function: Essential component of the BHC complex, a corepressor complex that represses transcription of
neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by
deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC
complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1,
that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone
H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A
from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC)
recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic
differentiation

Gene Wiki entry for RCOR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCOR1 gene promoter:
         TBP   ISGF-3   RP58   Lmo2   C/EBPalpha   Evi-1   CHOP-10   RORalpha1   AREB6   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RCOR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCOR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCOR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.31   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

RCOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCOR1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103059:  view genomic region     (about GC identifiers)

Start:
103,058,998 bp from pter      End:
103,196,913 bp from pter
Size:
137,916 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RCOR1_HUMAN, Q9UKL0 (See protein sequence)
Recommended Name: REST corepressor 1  
Size: 482 amino acids; 53028 Da
Subunit: Interacts directly with GFI1 and GFI1B in a RCOR/GFI/KDM1A/HDAC complex (By similarity). Component of a
BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80.
The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the
SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF
complex. Interacts with herpes virus HSV-1 ICP0 protein; the interaction leads to the disruption of the BHC
complex, thereby preventing the BHC complex from repressing transcription of viral genes
Subcellular location: Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an
HSV-1-dependent manner
Sequence caution: Sequence=AAH64495.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
6/19 PDB 3D structures from and Proteopedia for RCOR1 (see all 19):
2IW5 (3D)        2UXN (3D)        2UXX (3D)        2V1D (3D)        2X0L (3D)        2XAF (3D)    
Secondary accessions: Q15044 Q6P2I9 Q86VG5

Explore the universe of human proteins at neXtProt for RCOR1: NX_Q9UKL0

Explore proteomics data for RCOR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by HSV-1 protein kinases in case of infection
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKL0

  • RCOR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCOR1 Protein Expression
    REFSEQ proteins: NP_055971.2  
    ENSEMBL proteins: 
     ENSP00000262241   ENSP00000454204   ENSP00000459789  
    Reactome Protein details: Q9UKL0
    Human Recombinant Protein Products for RCOR1: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RCOR1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10449787
    GO:0005654nucleoplasm TAS--
    GO:0017053transcriptional repressor complex IDA10734093

    RCOR1 for ontologies           About GeneDecksing



    RCOR1 Antibody Products: 
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    Abcam antibodies for RCOR1
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    Search ThermoFisher Antibodies for RCOR1
    LSBio Antibodies in human, mouse, rat for RCOR1 

    Assay Products for RCOR1: 
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    Cloud-Clone Corp. ELISAs for RCOR1 
    Cloud-Clone Corp. CLIAs for RCOR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR000949 ELM2_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UKL0

    ProtoNet protein and cluster: Q9UKL0

    1 Blocks protein domain: IPB001005 Myb DNA-binding domain

    UniProtKB/Swiss-Prot: RCOR1_HUMAN, Q9UKL0
    Domain: The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A
    Similarity: Belongs to the CoREST family
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 2 SANT domains


    RCOR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCOR1_HUMAN, Q9UKL0
    Function: Essential component of the BHC complex, a corepressor complex that represses transcription of
    neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by
    deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC
    complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1,
    that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone
    H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A
    from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC)
    recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic
    differentiation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA10449787
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI10449787
    GO:0044212transcription regulatory region DNA binding IDA17555596
         
    RCOR1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCOR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCOR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCOR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCOR1 

    miRNA
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    miRTarBase miRNAs that target RCOR1:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCOR1
    8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate RCOR1 (see all 108):
    hsa-miR-3607-3p hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p hsa-miR-374a hsa-miR-30d hsa-miR-3653 hsa-miR-3161
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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                         Customized lentivirus expression plasmids for stable overexpression of RCOR1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RCOR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.47
    2Platelet activation, signaling and aggregation
    Hemostasis0.43
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for RCOR1
        Hemostasis
    Factors involved in megakaryocyte development and platelet production


    1         Kegg Pathway  (Kegg details for RCOR1):
        Huntington's disease


    RCOR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RCOR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/828 Interacting proteins for RCOR1 (Q9UKL01, 2, 3 ENSP000002622414) via UniProtKB, MINT, STRING, and/or I2D (see all 828)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0030218erythrocyte differentiation ----
    GO:0045654positive regulation of megakaryocyte differentiation ----
    GO:0045892negative regulation of transcription, DNA-dependent IDA10449787

    RCOR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RCOR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCOR1

    1 Novoseek inferred chemical compound relationship for RCOR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 15.4 1 10449787 (1)

    Search CenterWatch for drugs/clinical trials and news about RCOR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCOR1 gene: 
    NM_015156.3  

    Unigene Cluster for RCOR1:

    REST corepressor 1
    Hs.510521  [show with all ESTs]
    Unigene Representative Sequence: NM_015156
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262241(uc001ymb.3) ENST00000558495 ENST00000559597 ENST00000560472
    ENST00000570597
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCOR1
    8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate RCOR1 (see all 108):
    hsa-miR-3607-3p hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p hsa-miR-374a hsa-miR-30d hsa-miR-3653 hsa-miR-3161
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AF070627.1 AF155595.1 AK026612.1 BC051003.1 BC064495.1 D31888.1 

    7 DOTS entries:

    DT.118419  DT.95279140  DT.40198066  DT.40192814  DT.92429738  DT.95230251  DT.100650618 

    24/212 AceView cDNA sequences (see all 212):

    N79172 AA742268 AA262883 BC051003 BQ933786 AA337568 CA443485 BG576156 
    BM975991 CB127889 BE301408 AW628690 BC064495 AA482034 AA236061 CB127320 
    AW179055 BX494913 BM679322 AI086014 AF070627 BM720612 T65240 BQ026678 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCOR1 expression in normal human tissues (normalized intensities)      RCOR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGTGATG
    RCOR1 Expression
    About this image


    RCOR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   

    See RCOR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCOR1

    SOURCE GeneReport for Unigene cluster: Hs.510521

    UniProtKB/Swiss-Prot: RCOR1_HUMAN, Q9UKL0
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including RCOR1: 
              Huntington's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RCOR1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcor11 , 5 REST corepressor 11, 5 88.63(n)1
    96.33(a)1
      12 (60.93 cM)5
    2178641  NM_198023.21  NP_932140.11 
     1110393515 
    chicken
    (Gallus gallus)
    Aves RCOR11 REST corepressor 1 84.11(n)
    95.07(a)
      428911  XM_426467.3  XP_426467.3 
    lizard
    (Anolis carolinensis)
    Reptilia RCOR16
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343232.1(1400418-1564379)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ311849.12   -- 75.28(n)    AJ311849.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.179382 Transcribed sequence with weak similarity to protein more 76.56(n)    AL721531.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CoRest6
    CoRest
    21(a)
    1 → many
    X(19415962-19424929)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNT16
    Subunit of the Set3C deacetylase complex that inte...
    5(a)
    1 → many
    III(186489-190169)


    ENSEMBL Gene Tree for RCOR1 (if available)
    TreeFam Gene Tree for RCOR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCOR1 gene
    RCOR22  RCOR32  
    2 SIMAP similar genes for RCOR1 using alignment to 4 protein entries:     RCOR1_HUMAN (see all proteins):
    RCOR3    RCOR2

    RCOR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RCOR1
    PGOHUM00000262184


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2881 SNPs in RCOR1 are shown (see all 2881)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18152621,2
    C,F,A,H--83234010(+) TGTTTT/CCTGTA 1 -- us2k128Minor allele frequency- C:0.23MN NA NS EA WA CSA 2719
    rs1903255921,2
    --83234014(+) TCCTGC/TATTTT 1 -- us2k10--------
    rs1392264651,2
    --83234056(+) TACAGC/TATCGG 1 -- us2k10--------
    rs1440930741,2
    --83234070(+) AGCATC/TAGGGT 1 -- us2k10--------
    rs3726220401,2
    C--83331027(+) TTCCT-/CTTT/T
            
    TTTTT
    1 -- int10--------
    rs204861,2
    F--84052432(+) AAAAGAT/-CGCAT 1 -- int11Minor allele frequency- -:0.50NA 30
    rs1829268351,2
    --103057247(+) CAAGCA/GAGCGG 1 -- us2k10--------
    rs7495431,2
    C,F,A,H--103057250(-) GCCCCT/GCTCGC 1 -- us2k111Minor allele frequency- G:0.33MN NA WA EA 556
    rs7495421,2
    C,F,A,H--103057280(-) CTGTGT/CGAGGA 1 -- us2k16Minor allele frequency- C:0.03NA EA CSA WA 358
    rs1460110181,2
    C--103057482(+) GTGGGA/GGAAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RCOR1 (103058998 - 103196913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for RCOR1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670597CNV Deletion23128226
    esv2663482CNV Deletion23128226
    nsv1430CNV Insertion18451855
    esv26391CNV Loss19812545
    nsv832880CNV Loss17160897
    nsv516226CNV Loss19592680
    nsv902255CNV Loss21882294
    nsv512377CNV Loss21212237
    esv25323CNV Gain19812545
    dgv263n27CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607675    OMIM disorders: --

    7 diseases for RCOR1:    About MalaCards
    fg syndrome    herpes simplex    huntington's disease    mental retardation
    neuroblastoma    neuronitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RCOR1:
    FG syndrome

    RCOR1 for disorders           About GeneDecksing


    Export disorders for RCOR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCOR1 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with RCOR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CoREST: a functional corepressor required for regulation of neural- specific gene expression. (PubMed id 10449787)1, 2, 3, 9 Andres M.E.... Mandel G. (1999)
    2. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. (PubMed id 16079794)1, 2, 9 Lee M.G.... Shiekhattar R. (2005)
    3. CoREST is an integral component of the CoREST-human histone deacetylase complex. (PubMed id 11171972)1, 2, 9 You A.... Schreiber S.L. (2001)
    4. Regulation of LSD1 histone demethylase activity by its associated factors. (PubMed id 16140033)1, 2, 9 Shi Y.-J.... Shi Y. (2005)
    5. Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. (PubMed id 15897453)1, 2, 9 Gu H.... Roizman B. (2005)
    6. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. (PubMed id 16885027)1, 2, 9 Yang M.... Yu H. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PubMed id 12493763)1, 2 Hakimi M.A....Shiekhattar R. (2003)
    10. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. (PubMed id 12032298)1, 2 Hakimi M.A....Shiekhattar R. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23186 HGNC: 17441 AceView: RCOR1 Ensembl:ENSG00000089902 euGenes: HUgn23186
    ECgene: RCOR1 Kegg: 23186 H-InvDB: RCOR1

    (According to HUGE)
    About This Section
    HUGE: KIAA0071

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCOR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCOR1 gene:
    Search GeneIP for patents involving RCOR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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