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Aliases for RCOR1 Gene

Aliases for RCOR1 Gene

  • REST Corepressor 1 2 3 5
  • RCOR 3 4
  • REST Corepressor 2
  • Protein CoREST 4
  • KIAA0071 4
  • COREST 3

External Ids for RCOR1 Gene

Previous HGNC Symbols for RCOR1 Gene

  • RCOR

Previous GeneCards Identifiers for RCOR1 Gene

  • GC14P101050
  • GC14P102128
  • GC14P103059
  • GC14P083236

Summaries for RCOR1 Gene

Entrez Gene Summary for RCOR1 Gene

  • This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

GeneCards Summary for RCOR1 Gene

RCOR1 (REST Corepressor 1) is a Protein Coding gene. Among its related pathways are Chromatin organization and Platelet activation, signaling and aggregation. GO annotations related to this gene include chromatin binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NCOR1.

UniProtKB/Swiss-Prot for RCOR1 Gene

  • Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Gene Wiki entry for RCOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR1 Gene

Genomics for RCOR1 Gene

Regulatory Elements for RCOR1 Gene

Enhancers for RCOR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RCOR1 on UCSC Golden Path with GeneCards custom track

Promoters for RCOR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RCOR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RCOR1 Gene

Chromosome:
14
Start:
102,592,639 bp from pter
End:
102,730,576 bp from pter
Size:
137,938 bases
Orientation:
Plus strand

Genomic View for RCOR1 Gene

Genes around RCOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR1 Gene

Proteins for RCOR1 Gene

  • Protein details for RCOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKL0-RCOR1_HUMAN
    Recommended name:
    REST corepressor 1
    Protein Accession:
    Q9UKL0
    Secondary Accessions:
    • Q15044
    • Q6P2I9
    • Q86VG5

    Protein attributes for RCOR1 Gene

    Size:
    482 amino acids
    Molecular mass:
    53028 Da
    Quaternary structure:
    • Interacts directly with GFI1 and GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1 (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF complex. Interacts with herpes virus HSV-1 ICP0 protein; the interaction leads to the disruption of the BHC complex, thereby preventing the BHC complex from repressing transcription of viral genes.
    SequenceCaution:
    • Sequence=AAH64495.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCOR1 Gene

neXtProt entry for RCOR1 Gene

Proteomics data for RCOR1 Gene at MOPED

Post-translational modifications for RCOR1 Gene

Other Protein References for RCOR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RCOR1 (RCOR1)

No data available for DME Specific Peptides for RCOR1 Gene

Domains & Families for RCOR1 Gene

Gene Families for RCOR1 Gene

Protein Domains for RCOR1 Gene

Suggested Antigen Peptide Sequences for RCOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKL0

UniProtKB/Swiss-Prot:

RCOR1_HUMAN :
  • The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A.
  • Belongs to the CoREST family.
Domain:
  • The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A.
  • Contains 1 ELM2 domain.
  • Contains 2 SANT domains.
Family:
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR1: view

Function for RCOR1 Gene

Molecular function for RCOR1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Gene Ontology (GO) - Molecular Function for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044212 transcription regulatory region DNA binding IDA 17555596
genes like me logo Genes that share ontologies with RCOR1: view
genes like me logo Genes that share phenotypes with RCOR1: view

Animal Models for RCOR1 Gene

MGI Knock Outs for RCOR1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCOR1 Gene

Localization for RCOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR1 Gene

Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCOR1 Gene COMPARTMENTS Subcellular localization image for RCOR1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with RCOR1: view

Pathways & Interactions for RCOR1 Gene

genes like me logo Genes that share pathways with RCOR1: view

Pathways by source for RCOR1 Gene

Gene Ontology (GO) - Biological Process for RCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070933 histone H4 deacetylation IDA 17555596
genes like me logo Genes that share ontologies with RCOR1: view

No data available for SIGNOR curated interactions for RCOR1 Gene

Drugs & Compounds for RCOR1 Gene

(1) Drugs for RCOR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RCOR1: view

Transcripts for RCOR1 Gene

Unigene Clusters for RCOR1 Gene

REST corepressor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR1 Gene

No ASD Table

Relevant External Links for RCOR1 Gene

GeneLoc Exon Structure for
RCOR1
ECgene alternative splicing isoforms for
RCOR1

Expression for RCOR1 Gene

mRNA expression in normal human tissues for RCOR1 Gene

Protein differential expression in normal tissues from HIPED for RCOR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2), Testis (8.1), and Lung (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RCOR1 Gene



SOURCE GeneReport for Unigene cluster for RCOR1 Gene Hs.510521

mRNA Expression by UniProt/SwissProt for RCOR1 Gene

Q9UKL0-RCOR1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with RCOR1: view

Protein tissue co-expression partners for RCOR1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RCOR1 Gene

Orthologs for RCOR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RCOR1 35
  • 91.81 (n)
  • 96.86 (a)
RCOR1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCOR1 35
  • 93.12 (n)
  • 98.23 (a)
RCOR1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcor1 35
  • 88.63 (n)
  • 96.33 (a)
Rcor1 16
Rcor1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RCOR1 35
  • 97.44 (n)
  • 96.27 (a)
RCOR1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102554884 35
  • 86.61 (n)
  • 94.23 (a)
oppossum
(Monodelphis domestica)
Mammalia RCOR1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves RCOR1 35
  • 84.2 (n)
  • 95.34 (a)
RCOR1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCOR1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor1 35
  • 76.8 (n)
  • 83.29 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17938 35
rcor1 35
  • 68.31 (n)
  • 74.35 (a)
rcor1 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6894 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002488 35
  • 54.75 (n)
  • 52.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoRest 35
  • 55.37 (n)
  • 50.5 (a)
CoRest 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rcor-1 36
  • 15 (a)
ManyToMany
spr-1 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12954 35
Species with no ortholog for RCOR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR1 Gene

ENSEMBL:
Gene Tree for RCOR1 (if available)
TreeFam:
Gene Tree for RCOR1 (if available)

Paralogs for RCOR1 Gene

Paralogs for RCOR1 Gene

(2) SIMAP similar genes for RCOR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RCOR1 Gene

genes like me logo Genes that share paralogs with RCOR1: view

Variants for RCOR1 Gene

Sequence variations from dbSNP and Humsavar for RCOR1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs20485 -- 102,594,269(+) AGCAT(C/T)TTGTA intron-variant
rs7140399 -- 102,612,491(+) ACCAC(C/G)CCCGG intron-variant
rs7401248 -- 102,632,779(+) cctcc(C/T)ctctc intron-variant
rs7401249 -- 102,632,792(+) ctcTC(C/G)TCTCT intron-variant
rs2759404 -- 102,632,839(+) acagg(A/T)tctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCOR1 Gene

Variant ID Type Subtype PubMed ID
nsv832880 CNV Loss 17160897
dgv263n27 CNV Gain 19166990
nsv902255 CNV Loss 21882294
nsv1430 CNV Insertion 18451855
nsv7257 OTHER Inversion 18451855
nsv516226 CNV Loss 19592680
nsv512377 CNV Loss 21212237
esv2663482 CNV Deletion 23128226
esv26391 CNV Loss 19812545
esv25323 CNV Gain 19812545
esv2670597 CNV Deletion 23128226
nsv902258 CNV Gain 21882294

Variation tolerance for RCOR1 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RCOR1 Gene

Disorders for RCOR1 Gene

Relevant External Links for RCOR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCOR1

No disorders were found for RCOR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCOR1 Gene

Publications for RCOR1 Gene

  1. CoREST: a functional corepressor required for regulation of neural- specific gene expression. (PMID: 10449787) Andres M.E. … Mandel G. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. Gfi-1B promoter remains associated with active chromatin marks throughout erythroid differentiation of human primary progenitor cells. (PMID: 19522008) Laurent B. … DumAcnil D. (Stem Cells 2009) 3 23
  3. Transrepressive function of TLX requires the histone demethylase LSD1. (PMID: 18391013) Yokoyama A. … Kato S. (Mol. Cell. Biol. 2008) 3 23
  4. Esco2 is a novel corepressor that associates with various chromatin modifying enzymes. (PMID: 18501190) Kim B.J. … Kim S.T. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. CoREST represses the heat shock response mediated by HSF1. (PMID: 18657505) GA^mez A.V. … AndrAcs M.E. (Mol. Cell 2008) 3 23

Products for RCOR1 Gene

Sources for RCOR1 Gene

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