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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RCN3 Gene

protein-coding GIFtS: 50
GCID: GC19P050030

reticulocalbin 3, EF-hand calcium binding domain

Explore 4 diseases affiliated with
RCN3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Reticulocalbin 3, EF-Hand Calcium Binding Domain¹ ²
RLP49¹ ²
EF-Hand Calcium-Binding Protein RLP49² ³
Reticulocabin¹
Reticulocalbin-3¹

External Ids:	HGNC: 21145¹	Entrez Gene: 57333²	Ensembl: ENSG00000142552⁷	UniProtKB: Q96D15³

Export aliases for RCN3 gene to outside databases

Previous GC identifers: GC19P054706 GC19P054722 GC19P046407

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RCN3 gene promoter:
Bach1 Elk-1 ISGF-3 Sp1 Bach2 STAT5A Egr-4 Egr-2 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RCN3 promoter sequence

Search SABiosciences Chromatin IP Primers for RCN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33

RCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCN3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P050030: view genomic region (about GC identifiers)

Start:	50,030,875 bp from pter	End:	50,046,890 bp from pter
Size:	16,016 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RCN3_HUMAN, Q96D15 (See protein sequence)

Recommended Name: Reticulocalbin-3 precursor

Size: 328 amino acids; 37493 Da

Subcellular location: Endoplasmic reticulum lumen (Potential)

Secondary accessions: Q9HBZ8

Explore the universe of human proteins at neXtProt for RCN3: NX_Q96D15

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96D15

RCN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065701.2

ENSEMBL proteins:

ENSP00000270645

Human Recombinant Protein Products for RCN3:

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005788	endoplasmic reticulum lumen	IEA	--

RCN3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RCN3 for domains About GeneDecksing

3 InterPro domains/families:

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR018247 EF_Hand_1_Ca_BS

Graphical View of Domain Structure for InterPro Entry Q96D15

ProtoNet protein and cluster: Q96D15

UniProtKB/Swiss-Prot: RCN3_HUMAN, Q96D15

Similarity: Belongs to the CREC family

Similarity: Contains 6 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	16189514

RCN3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RCN3:

Elongated cells

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RCN3

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RCN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/14 Interacting proteins for RCN3 (Q96D15^{1, 2, 3} ENSP00000270645⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRUNE2	Q8WUY3²^,³, ENSP00000365908⁴	MINT-66808 I2D: score=3 STRING: ENSP00000365908
SUFU	Q9UMX1¹^,²^,³, ENSP00000358918⁴	EBI-746283,EBI-740595 MINT-67210 I2D: score=6 STRING: ENSP00000358918
HIST2H2AA3	Q6FI13³	I2D: score=1
HIST2H2AA4	Q6FI13³	I2D: score=1
PCSK6	P29122³, ENSP00000332052⁴	I2D: score=1 STRING: ENSP00000332052

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RCN3
Search CenterWatch for drugs/clinical trials and news about RCN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for RCN3 gene:

NM_020650.2

Unigene Cluster for RCN3:

Reticulocalbin 3, EF-hand calcium binding domain

Hs.567550 [show with all ESTs]

Unigene Representative Sequence: AY195859

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000270645(uc002poj.3)

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate RCN3:
		hsa-miR-137
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Additional cDNA sequence:

AF183423.1 AY195859.1 AY358423.1 BC013436.1

7 DOTS entries:

DT.211915 DT.86794827 DT.92429117 DT.92429118 DT.95325837 DT.121504240 DT.91771685

9 AceView cDNA sequences:

AY358423 AY195859 CR593314 CR603643 CR626627 NM_020650 CR609238 BC013436

AF183423

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RCN3 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7
SP1:
SP2:																			-
SP3:							-

ECgene alternative splicing isoforms for RCN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RCN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTGGGCA

About this image

RCN3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RCN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RCN3

SOURCE GeneReport for Unigene cluster: Hs.567550

SABiosciences Custom PCR Arrays for RCN3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCN3 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rcn3^{1 , 5}	reticulocalbin 3, EF-hand calcium binding domain^{1, 5}	87.2(n)¹ 92.68(a)¹		7 (29.11 cM)⁵ 52377¹ NM_026555.2¹ NP_080831.2¹ 45082913⁵
lizard (Anolis carolinensis)	Reptilia	RCN3⁶	--	60(a)	1 ↔ 1	6(80441128-80452196)
zebrafish (Danio rerio)	Actinopterygii	rcn3¹	reticulocalbin 3, EF-hand calcium binding domain	60.65(n) 61.2(a)		415248 NM_001002158.1 NP_001002158.1
fruit fly (Drosophila melanogaster)	Insecta	scf⁶	supercoiling factor	41(a)	1 → many	3L(1298672-1300389)
worm (Caenorhabditis elegans)	Secernentea	calu-1⁶	CALUmenin (calcium-binding protein) homolog family...	39(a)	1 → many	X(4969502-4970882)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G27790⁶ AT5G08580⁶	EF-hand, calcium binding motif-containing protein	20(a) 16(a)	many ↔ many many ↔ many	4(13850046-13851533) 5(2780512-2783066)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	EF hand family protein, putative, expressed calcium-binding EF hand family protein, putative, ... (see all 3)	18(a) 15(a) (see all 3)	many ↔ many many ↔ many (see all 3)	4(34602257-34605106) 2(6798696-6802474)

ENSEMBL Gene Tree for RCN3 (if available)
TreeFam Gene Tree for RCN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RCN3 gene

RCN1² CALU² RCN2² SDF4²

3 SIMAP similar genes for RCN3 using alignment to 4 protein entries: RCN3_HUMAN (see all proteins):

RCN1 CALU RCN2

RCN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149836518^1,2		--	50030468(+)	`AAGAGA/GAGCGA`	1	--	us2k¹		0	--	--	--	--
rs183518825^1,2		--	50030471(+)	`AGGAGC/TGAGGA`	1	--	us2k¹		0	--	--	--	--
rs147933469^1,2		--	50030475(+)	`GCGAGA/GAGCAG`	1	--	us2k¹		0	--	--	--	--
rs142015875^1,2		--	50030480(+)	`GAGCAC/GTGTTC`	1	--	us2k¹		0	--	--	--	--
rs78025330^1,2	C	--	50030541(+)	`CTTTTC/TTTTTC`	1	--	us2k¹		4		CSA WA NA EA	360
rs150802171^1,2	C	--	50030560(+)	`TCTTT-/CTTTTT`	1	--	us2k¹		0	--	--	--	--
rs144331875^1,2		--	50030594(+)	`TTGTTA/GCCCAG`	1	--	us2k¹		0	--	--	--	--
rs147761887^1,2		--	50030691(+)	`GCTGGA/GATTAA`	1	--	us2k¹		0	--	--	--	--
rs148832708^1,2		--	50030692(+)	`CTGGGA/GTTAAA`	1	--	us2k¹		0	--	--	--	--
rs112330409^1,2	C,F	--	50030701(+)	`AAGACC/ATGCGC`	1	--	us2k¹		2		WA CSA	4

HapMap Linkage Disequilibrium report for RCN3 (50030875 - 50046890 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RCN3
3 CNVs: 5111 5110 32261

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RCN3 for disorders About GeneDecksing

4 diseases for RCN3: About MalaCards

ollier disease chondroblastoma malaria neuronitis

1 disease from the University of Copenhagen DISEASES database for RCN3:

Ollier disease

Export disorders for RCN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RCN3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with RCN3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (2000)
A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4. (PubMed id 16433634)^{1, 9} Tsuji A....Matsuda Y. (2006)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57333	HGNC: 21145	AceView: RCN3	Ensembl:ENSG00000142552	euGenes: HUgn57333
ECgene: RCN3	H-InvDB: RCN3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RCN3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RCN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RCN3 gene:
Search GeneIP for patents involving RCN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for RCN3
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RCN3
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	GenScript Custom Purified and Recombinant Proteins Services for RCN3		GenScript cDNA clones with any tag delivered in your preferred vector for RCN3
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ThermoFisher Antibodies for RCN3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCN3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RCN3

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RCN3 gene at Home site.

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RCN3 Gene

reticulocalbin 3, EF-hand calcium binding domain

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RCN3 Gene

reticulocalbin 3, EF-hand calcium binding domain

Aliasesfor RCN3 gene

Summariesfor RCN3 gene

Genomic Viewsfor RCN3 gene

Proteinsfor RCN3 gene

Protein Domains /Familiesfor RCN3 gene

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for RCN3 gene

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