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RCN3 Gene

protein-coding   GIFtS: 54
GCID: GC19P050030

Reticulocalbin 3, EF-Hand Calcium Binding Domain

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reticulocalbin 3, EF-Hand Calcium Binding Domain1 2
EF-Hand Calcium-Binding Protein RLP492 3
RLP492
reticulocabin2
reticulocalbin-32

External Ids:    HGNC: 211451   Entrez Gene: 573332   Ensembl: ENSG000001425527   UniProtKB: Q96D153   

Export aliases for RCN3 gene to outside databases

Previous GC identifers: GC19P054706 GC19P054722 GC19P046407


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RCN3 Gene:
RCN3 (reticulocalbin 3, EF-hand calcium binding domain) is a protein-coding gene. Diseases associated with RCN3 include chondroblastoma, and ollier disease. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is RCN1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RCN3 gene promoter:
         Bach1   Elk-1   ISGF-3   Sp1   Bach2   STAT5A   Egr-4   Egr-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RCN3 promoter sequence
   Search Chromatin IP Primers for RCN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RCN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

RCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCN3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050030:  view genomic region     (about GC identifiers)

Start:
50,030,875 bp from pter      End:
50,050,219 bp from pter
Size:
19,345 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RCN3_HUMAN, Q96D15 (See protein sequence)
Recommended Name: Reticulocalbin-3 precursor  
Size: 328 amino acids; 37493 Da
Secondary accessions: Q9HBZ8

Explore the universe of human proteins at neXtProt for RCN3: NX_Q96D15

Explore proteomics data for RCN3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn140
  • Modification sites at PhosphoSitePlus

  • See RCN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065701.2  
    ENSEMBL proteins: 
     ENSP00000270645   ENSP00000469727   ENSP00000470540   ENSP00000470771  

    RCN3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for RCN3
    Cloud-Clone Corp. CLIAs for RCN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q96D15

    ProtoNet protein and cluster: Q96D15

    UniProtKB/Swiss-Prot: RCN3_HUMAN, Q96D15
    Similarity: Belongs to the CREC family
    Similarity: Contains 6 EF-hand domains


    RCN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16189514
         
    RCN3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RCN3:
     Elongated cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RCN3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCN3

    miRNA
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    miRTarBase miRNAs that target RCN3:
    hsa-mir-92a-3p (MIRT049606)

    Block miRNA regulation of human, mouse, rat RCN3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RCN3:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidRCN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RCN3
    Predesigned siRNA for gene silencing in human, mouse, rat RCN3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RCN3 (NM_020650)
    Sino Biological Human cDNA Clone for RCN3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCN3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RCN3_HUMAN, Q96D15: Endoplasmic reticulum lumen (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum3
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IEA--

    RCN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RCN3
    Interactions:

        Search GeneGlobe Interaction Network for RCN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RCN3 (Q96D151, 2, 3 ENSP000002706454) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRUNE2Q8WUY32, 3, ENSP000003659084MINT-66808 I2D: score=3 STRING: ENSP00000365908
    SUFUQ9UMX11, 2, 3, ENSP000003589184EBI-746283,EBI-740595 MINT-67210 I2D: score=6 STRING: ENSP00000358918
    HIST2H2AA3Q6FI133I2D: score=1 
    HIST2H2AA4Q6FI133I2D: score=1 
    PCSK6P291223, ENSP000003320524I2D: score=1 STRING: ENSP00000332052
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RCN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RCN3 gene: 
    NM_020650.2  

    Unigene Cluster for RCN3:

    Reticulocalbin 3, EF-hand calcium binding domain
    Hs.567550  [show with all ESTs]
    Unigene Representative Sequence: AY195859
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270645(uc002poj.3) ENST00000597801 ENST00000593644 ENST00000598833
    ENST00000593483
    miRNA
    Products:
         
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    1 qRT-PCR Assays for microRNA that regulate RCN3:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidRCN3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RCN3
    Predesigned siRNA for gene silencing in human, mouse, rat RCN3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RCN3 (NM_020650)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCN3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RCN3
      QuantiTect SYBR Green Assays in human, mouse, rat RCN3
      QuantiFast Probe-based Assays in human, mouse, rat RCN3

    Additional mRNA sequence: 

    AF183423.1 AY195859.1 AY358423.1 BC013436.1 

    7 DOTS entries:

    DT.211915  DT.86794827  DT.92429117  DT.92429118  DT.95325837  DT.121504240  DT.91771685 

    9 AceView cDNA sequences:

    AY195859 CR626627 AY358423 CR603643 CR609238 BC013436 NM_020650 CR593314 
    AF183423 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RCN3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
    SP1:                                                                  
    SP2:                                                        -         
    SP3:                    -                                             


    ECgene alternative splicing isoforms for RCN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RCN3 expression in normal human tissues (normalized intensities)      RCN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGGGCA
    RCN3 Expression
    About this image


    RCN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
    RCN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RCN3 Protein Expression

    Genevestigator expression for RCN3

    SOURCE GeneReport for Unigene cluster: Hs.567550
        Custom PCR Arrays for RCN3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RCN3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcn31 , 5 reticulocalbin 3, EF-hand calcium binding domain1, 5 87.2(n)1
    92.68(a)1
      7 (29.11 cM)5
    523771  NM_026555.21  NP_080831.21 
     450829135 
    lizard
    (Anolis carolinensis)
    Reptilia RCN36
    reticulocalbin 3, EF-hand calcium binding domain
    61(a)
    1 ↔ 1
    6(80437670-80452196)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rcn31 reticulocalbin 3, EF-hand calcium binding domain 63.05(n)
    60.34(a)
      395023  NM_204058.1  NP_989389.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rcn31 reticulocalbin 3, EF-hand calcium binding domain 60.54(n)
    61.2(a)
      415248  NM_001002158.1  NP_001002158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scf6
    supercoiling factor
    44(a)
    1 → many
    3L(1298672-1300389)
    worm
    (Caenorhabditis elegans)
    Secernentea calu-16
    Protein CALU-1, isoform a
    40(a)
    1 → many
    X(4969533-4970911) WBGene00019760


    ENSEMBL Gene Tree for RCN3 (if available)
    TreeFam Gene Tree for RCN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RCN3 gene
    RCN12  CALU2  SDF42  RCN22  
    3 SIMAP similar genes for RCN3 using alignment to 4 protein entries:     RCN3_HUMAN (see all proteins):
    RCN1    CALU    RCN2

    RCN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RCN3 (see all 449)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498365181,2
    C--50030468(+) AAGAGA/GAGCGA 1 -- us2k10--------
    rs1835188251,2
    --50030471(+) AGGAGC/TGAGGA 1 -- us2k10--------
    rs1479334691,2
    C--50030475(+) GCGAGA/GAGCAG 1 -- us2k10--------
    rs1420158751,2
    --50030480(+) GAGCAC/GTGTTC 1 -- us2k10--------
    rs780253301,2
    C--50030541(+) CTTTTC/TTTTTC 1 -- us2k14Minor allele frequency- T:0.14CSA WA NA EA 360
    rs1508021711,2
    C--50030560(+) TCTTT-/CTTTTT 1 -- us2k10--------
    rs1443318751,2
    --50030594(+) TTGTTA/GCCCAG 1 -- us2k10--------
    rs1477618871,2
    --50030691(+) GCTGGA/GATTAA 1 -- us2k10--------
    rs1488327081,2
    C--50030692(+) CTGGGA/GTTAAA 1 -- us2k10--------
    rs1123304091,2
    C,F--50030701(+) AAGACC/ATGCGC 1 -- us2k12Minor allele frequency- A:0.50WA CSA 4

    HapMap Linkage Disequilibrium report for RCN3 (50030875 - 50050219 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RCN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833862CNV Loss17160897
    nsv912262CNV Loss21882294
    nsv833863CNV Loss17160897
    nsv912261CNV Loss21882294
    nsv912265CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for RCN3:    About MalaCards
    chondroblastoma    ollier disease    neuronitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for RCN3:
    Ollier disease

    RCN3 for disorders           About GeneDecksing


    Export disorders for RCN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RCN3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with RCN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    4. A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4. (PubMed id 16433634)1, 9 Tsuji A....Matsuda Y. (Biochem. J. 2006)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57333 HGNC: 21145 AceView: RCN3 Ensembl:ENSG00000142552 euGenes: HUgn57333
    ECgene: RCN3 H-InvDB: RCN3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RCN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RCN3 gene:
    Search GeneIP for patents involving RCN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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