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Aliases for RCN3 Gene

Aliases for RCN3 Gene

  • Reticulocalbin 3 2 3 5
  • Reticulocalbin 3, EF-Hand Calcium Binding Domain 2 3
  • EF-Hand Calcium-Binding Protein RLP49 3 4
  • Reticulocalbin-3 3
  • Reticulocabin 3
  • RLP49 3

External Ids for RCN3 Gene

Previous GeneCards Identifiers for RCN3 Gene

  • GC19P054706
  • GC19P054722
  • GC19P050030
  • GC19P046407

Summaries for RCN3 Gene

GeneCards Summary for RCN3 Gene

RCN3 (Reticulocalbin 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is RCN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCN3 Gene

Genomics for RCN3 Gene

Regulatory Elements for RCN3 Gene

Enhancers for RCN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RCN3 on UCSC Golden Path with GeneCards custom track

Promoters for RCN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RCN3 Gene

49,527,579 bp from pter
49,546,962 bp from pter
19,384 bases
Plus strand

Genomic View for RCN3 Gene

Genes around RCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCN3 Gene

Proteins for RCN3 Gene

  • Protein details for RCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9HBZ8

    Protein attributes for RCN3 Gene

    328 amino acids
    Molecular mass:
    37493 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RCN3 Gene

Post-translational modifications for RCN3 Gene

  • Glycosylation at Asn 140
  • Modification sites at PhosphoSitePlus

Other Protein References for RCN3 Gene

No data available for DME Specific Peptides for RCN3 Gene

Domains & Families for RCN3 Gene

Gene Families for RCN3 Gene

Protein Domains for RCN3 Gene

Suggested Antigen Peptide Sequences for RCN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 EF-hand domains.
  • Belongs to the CREC family.
  • Contains 6 EF-hand domains.
  • Belongs to the CREC family.
genes like me logo Genes that share domains with RCN3: view

Function for RCN3 Gene

Gene Ontology (GO) - Molecular Function for RCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RCN3: view
genes like me logo Genes that share phenotypes with RCN3: view

Animal Model Products

CRISPR Products

miRNA for RCN3 Gene

miRTarBase miRNAs that target RCN3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCN3 Gene

Localization for RCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCN3 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Jensen Localization Image for RCN3 Gene COMPARTMENTS Subcellular localization image for RCN3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with RCN3: view

Pathways & Interactions for RCN3 Gene

SuperPathways for RCN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCN3 Gene


No data available for Pathways by source and SIGNOR curated interactions for RCN3 Gene

Drugs & Compounds for RCN3 Gene

No Compound Related Data Available

Transcripts for RCN3 Gene

mRNA/cDNA for RCN3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RCN3 Gene

Reticulocalbin 3, EF-hand calcium binding domain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
SP2: -
SP3: -

Relevant External Links for RCN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RCN3 Gene

mRNA expression in normal human tissues for RCN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RCN3 Gene

This gene is overexpressed in Bone marrow stromal cell (56.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCN3 Gene

Protein tissue co-expression partners for RCN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RCN3 Gene:


SOURCE GeneReport for Unigene cluster for RCN3 Gene:

genes like me logo Genes that share expression patterns with RCN3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RCN3 Gene

Orthologs for RCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RCN3 34
  • 90.65 (n)
  • 96.34 (a)
RCN3 35
  • 96 (a)
(Canis familiaris)
Mammalia RCN3 34
  • 90.45 (n)
  • 95.73 (a)
RCN3 35
  • 95 (a)
(Mus musculus)
Mammalia Rcn3 34
  • 87.2 (n)
  • 92.68 (a)
Rcn3 16
Rcn3 35
  • 93 (a)
(Pan troglodytes)
Mammalia RCN3 34
  • 98.88 (n)
  • 99.39 (a)
RCN3 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Rcn3 34
  • 86.69 (n)
  • 93.29 (a)
(Monodelphis domestica)
Mammalia RCN3 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia RCN3 35
  • 66 (a)
(Anolis carolinensis)
Reptilia RCN3 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rcn3 34
  • 63.05 (n)
  • 60.34 (a)
(Danio rerio)
Actinopterygii rcn3 34
  • 60.54 (n)
  • 61.2 (a)
rcn3 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta scf 35
  • 44 (a)
(Caenorhabditis elegans)
Secernentea calu-1 35
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
-- 35
  • 45 (a)
CSA.6945 35
  • 40 (a)
Species where no ortholog for RCN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCN3 Gene

Gene Tree for RCN3 (if available)
Gene Tree for RCN3 (if available)

Paralogs for RCN3 Gene

Paralogs for RCN3 Gene

(3) SIMAP similar genes for RCN3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RCN3: view

Variants for RCN3 Gene

Sequence variations from dbSNP and Humsavar for RCN3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34654230 - 49,542,621(+) AGTTC(C/G/T)GGGAC reference, missense
rs3187346 -- 49,543,108(+) CAGGA(C/T)GGGCG reference, synonymous-codon
rs4296355 -- 49,528,903(+) GAGAC(C/T)GGGCG intron-variant
rs4491643 -- 49,539,417(+) ATACA(C/T)TTACT intron-variant
rs4491644 -- 49,539,421(+) ACTTA(C/T)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCN3 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv478163 CNV novel sequence insertion 20440878
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for RCN3 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCN3 Gene

Disorders for RCN3 Gene

Relevant External Links for RCN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RCN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCN3 Gene

Publications for RCN3 Gene

  1. A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4. (PMID: 16433634) Tsuji A. … Matsuda Y. (Biochem. J. 2006) 3 22 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for RCN3 Gene

Sources for RCN3 Gene

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