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RCN2 Gene

protein-coding   GIFtS: 60
GCID: GC15P077223

Reticulocalbin 2, EF-Hand Calcium Binding Domain

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reticulocalbin 2, EF-Hand Calcium Binding Domain1 2     EF-Hand Calcium Binding Domain (Endoplasmic Reticulum Calcium-Binding
Protein1
ERC552 3 5     Reticulocalbin 21
Calcium-Binding Protein ERC-552 3     ERC-552
E6BP2 3     TCBP492
E6-Binding Protein2 3     Reticulocalbin 2, EF-Hand Calcium Binding Domain (Endoplasmic Reticulum
Calcium-Binding Protein, 55kD)2
55kD)1     reticulocalbin-22

External Ids:    HGNC: 99351   Entrez Gene: 59552   Ensembl: ENSG000001179067   OMIM: 6025845   UniProtKB: Q142573   

Export aliases for RCN2 gene to outside databases

Previous GC identifers: GC15P073112 GC15P070314 GC15P074799 GC15P074939 GC15P075011 GC15P053980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RCN2 Gene:
The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains
six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the
same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Nov 2012)

GeneCards Summary for RCN2 Gene:
RCN2 (reticulocalbin 2, EF-hand calcium binding domain) is a protein-coding gene. Diseases associated with RCN2 include anogenital venereal wart, and bardet-biedl syndrome. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is RCN3.

UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257
Function: Not known. Binds calcium

Gene Wiki entry for RCN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RCN2 gene promoter:
         HFH-3   Sp1   MAZR   STAT5A   FOXL1   YY1   FOXI1   AREB6   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCN2 promoter sequence
   Search Chromatin IP Primers for RCN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RCN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q22.33-q24.1

RCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCN2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P077223:  view genomic region     (about GC identifiers)

Start:
77,223,960 bp from pter      End:
77,242,601 bp from pter
Size:
18,642 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257 (See protein sequence)
Recommended Name: Reticulocalbin-2 precursor  
Size: 317 amino acids; 36876 Da
Secondary accessions: A8MTG6 Q53XN8

Explore the universe of human proteins at neXtProt for RCN2: NX_Q14257

Explore proteomics data for RCN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys56, Lys64, Lys103, Lys232
  • Modification sites at PhosphoSitePlus

  • See RCN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258766.1  NP_002893.1  

    ENSEMBL proteins: 
     ENSP00000378349   ENSP00000319739   ENSP00000378347   ENSP00000453052  

    RCN2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q14257

    ProtoNet protein and cluster: Q14257

    UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257
    Similarity: Belongs to the CREC family
    Similarity: Contains 6 EF-hand domains


    RCN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCN2_HUMAN, Q14257
    Function: Not known. Binds calcium

         Genatlas biochemistry entry for RCN2:
    ERC55 endoplasmic reticulum,lumen protein,55kDa

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    RCN2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RCN2
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    miRNA
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    miRTarBase miRNAs that target RCN2:
    hsa-mir-26b-5p (MIRT029831), hsa-mir-100-5p (MIRT048556), hsa-mir-375 (MIRT019940), hsa-mir-183-5p (MIRT025032), hsa-mir-155-5p (MIRT001507), hsa-mir-99a-5p (MIRT048612)

    Block miRNA regulation of human, mouse, rat RCN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RCN2 (see all 23):
    hsa-miR-142-5p hsa-miR-320a hsa-miR-485-3p hsa-miR-138-2* hsa-miR-340 hsa-miR-1297 hsa-miR-548m hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidRCN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RCN2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCN2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RCN2_HUMAN, Q14257: Endoplasmic reticulum lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    cytosol1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005788endoplasmic reticulum lumen IEA--

    RCN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RCN2
    Interactions:

        Search GeneGlobe Interaction Network for RCN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for RCN2 (Q142571, 2, 3 ENSP000003783494) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-65300 I2D: score=5 
    ENSG00000096155P463792, 3MINT-65300 I2D: score=5 
    ENSG00000227761P463792, 3MINT-65300 I2D: score=5 
    ENSG00000228760P463792, 3MINT-65300 I2D: score=5 
    ENSG00000229524P463792, 3MINT-65300 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RCN2

    1 HMDB Compound for RCN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for RCN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 6 11878933 (3), 8034671 (2)



    RCN2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RCN2 gene (2 alternative transcripts): 
    NM_001271837.1  NM_002902.2  

    Unigene Cluster for RCN2:

    Reticulocalbin 2, EF-hand calcium binding domain
    Hs.79088  [show with all ESTs]
    Unigene Representative Sequence: AK126522
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394885(uc002bcd.3) ENST00000320963 ENST00000394883 ENST00000557805
    ENST00000558598 ENST00000560833
    miRNA
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    Block miRNA regulation of human, mouse, rat RCN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RCN2 (see all 23):
    hsa-miR-142-5p hsa-miR-320a hsa-miR-485-3p hsa-miR-138-2* hsa-miR-340 hsa-miR-1297 hsa-miR-548m hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidRCN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RCN2
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    GenScript: all cDNA clones in your preferred vector: RCN2 (NM_002902)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCN2
    Primer
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    OriGene qPCR primer pairs and template standards for RCN2
    OriGene qSTAR qPCR primer pairs in human, mouse for RCN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RCN2
      QuantiTect SYBR Green Assays in human, mouse, rat RCN2
      QuantiFast Probe-based Assays in human, mouse, rat RCN2

    Additional mRNA sequence: 

    AK126522.1 AK313833.1 AL110102.1 BC004892.2 BT009790.1 X78669.1 

    16 DOTS entries:

    DT.318622  DT.75190464  DT.100796156  DT.100796151  DT.100796158  DT.121063870  DT.100796144  DT.95156906 
    DT.100669856  DT.100796150  DT.100719096  DT.100796146  DT.100796153  DT.91765927  DT.97777713  DT.91993841 

    Selected AceView cDNA sequences (see all 383):

    AI310987 BM542690 CR596465 CR596223 AI312100 BF438299 AA471029 AU142576 
    CA487161 CR613141 CR597585 AL551035 CR599064 AA435823 AI583706 CR617037 
    AA328738 BU903024 CR596401 AI827056 AW439736 CR609330 BE782872 AL549974 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RCN2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                                      -     -     -     -     -                       -                     
    SP2:                                      -     -           -     -                                             
    SP3:                                      -     -           -     -                       -                     
    SP4:                                      -           -     -     -                                             
    SP5:                                                                                      -                     


    ECgene alternative splicing isoforms for RCN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RCN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGATTTTA
    RCN2 Expression
    About this image


    RCN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Cartilage (Muscoskeletal System)
             Laryngeal Cartilage
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
    RCN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RCN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79088

    UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RCN2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcn21 , 5 reticulocalbin 21, 5 88.75(n)1
    93.38(a)1
      9 (30.13 cM)5
    266111  NM_011992.21  NP_036122.21 
     560418455 
    chicken
    (Gallus gallus)
    Aves RCN21 reticulocalbin 2, EF-hand calcium binding domain 76.84(n)
    76.84(a)
      415350  XM_004943713.1  XP_004943770.1 
    lizard
    (Anolis carolinensis)
    Reptilia RCN26
    reticulocalbin 2, EF-hand calcium binding domain
    83(a)
    1 ↔ 1
    GL343374.1(955152-957362)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.94152 Xenopus laevis transcribed sequence with weak similarity more 77.69(n)    48050237 
    zebrafish
    (Danio rerio)
    Actinopterygii rcn21 reticulocalbin 2 59.15(n)
    52(a)
      571340  NM_001030263.1  NP_001025434.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91123
    CG316501
    calcium ion binding3
    CG316501
    36(a)3
    48.75(n)1
    37.37(a)1
      3261501  NM_164620.21  NP_723049.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F08B6.33 EF hand protein 32(a)   I(6766302-6768217)   --


    ENSEMBL Gene Tree for RCN2 (if available)
    TreeFam Gene Tree for RCN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RCN2 gene
    RCN32  RCN12  CALU2  SDF42  
    3 SIMAP similar genes for RCN2 using alignment to 5 protein entries:     RCN2_HUMAN (see all proteins):
    CALU    RCN1    RCN3

    RCN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RCN2 (see all 416)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153111741,2
    F--77222011(+) TTTAGG/ATAAAT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1411498041,2
    C--77222058(+) CTATAC/TGCTAT 2 -- us2k10--------
    rs1886542941,2
    --77222072(+) CTTTTA/TTAGGT 2 -- us2k10--------
    rs1928129171,2
    --77222075(+) TTATAA/GGTCAA 2 -- us2k10--------
    rs1462262371,2
    C--77222124(+) AACAGG/TCTACT 2 -- us2k10--------
    rs1391866571,2
    --77222154(+) TCCCCC/GAGTAG 2 -- us2k10--------
    rs1425949661,2
    --77222187(+) ACATTG/TGATCA 2 -- us2k10--------
    rs1853263551,2
    --77222200(+) CTTGCC/TTCTTT 2 -- us2k10--------
    rs1459889141,2
    C--77222256(+) AAATCA/GTTGAT 2 -- us2k10--------
    rs1396258421,2
    --77222409(+) ACACAC/TCACTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RCN2 (77223960 - 77242601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RCN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749898CNV Deletion23290073
    nsv833058CNV Loss17160897
    dgv757e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RCN2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602584    OMIM disorders: --

    9 diseases for RCN2:    
    About MalaCards
    anogenital venereal wart    bardet-biedl syndrome    cervical cancer    cervicitis
    cystic fibrosis    neuroblastoma    malaria    neuronitis
    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for RCN2:
    Anogenital venereal wart

    RCN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RCN2
    Human Genome Epidemiology (HuGE) Navigator: RCN2 (2 documents)

    Export disorders for RCN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RCN2 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with RCN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. (PubMed id 8034671)1, 2, 9 Weis K.... Lamond A.I. (J. Biol. Chem. 1994)
    2. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. (PubMed id 7624774)1, 3, 9 Chen J.J....Androphy E.J. (Science 1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33--&gt;q24.1 by in situ hybridization. (PubMed id 9533013)1, 3 Wang J.Y....Chen J.J. (Cytogenet. Cell Genet. 1997)
    5. Identification and characterization of novel ERC-55 interacting proteins: evidence for the existence of several ERC-55 splicing variants; including the cytosolic ERC-55-C. (PubMed id 19927312)1, 9 Ludvigsen M....HonorAc B. (Proteomics 2009)
    6. Gene expression analysis in absence epilepsy using a monozygotic twin design. (PubMed id 18435749)1, 9 Helbig I....Hayward N.K. (Epilepsia 2008)
    7. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5955 HGNC: 9935 AceView: RCN2 Ensembl:ENSG00000117906 euGenes: HUgn5955
    ECgene: RCN2 H-InvDB: RCN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RCN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCN2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RCN2 gene:
    Search GeneIP for patents involving RCN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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