Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCN2 Gene

protein-coding   GIFtS: 59
GCID: GC15P077223

reticulocalbin 2, EF-hand calcium binding domain
 Explore 8 diseases affiliated with
RCN2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RCN2    

Aliases
for RCN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Reticulocalbin 2, EF-Hand Calcium Binding Domain1 2     Calcium-Binding Protein ERC-552 3
ERC551 2 3 5     E6-Binding Protein2 3
E6BP1 2 3     Reticulocalbin 2, EF-Hand Calcium Binding Domain (Endoplasmic Reticulum
Calcium-Binding Protein, 55kD)2
ERC-551 2     Reticulocalbin-21
TCBP491 2     

External Ids:    HGNC: 99351   Entrez Gene: 59552   Ensembl: ENSG000001179067   OMIM: 6025845   UniProtKB: Q142573   

Export aliases for RCN2 gene to outside databases

Previous GC identifers: GC15P073112 GC15P070314 GC15P074799 GC15P074939 GC15P075011 GC15P053980


Summaries
for RCN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RCN2:
The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six
conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same
region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257
Function: Not known. Binds calcium

Gene Wiki entry for RCN2


Genomic Views
for RCN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCN2 gene promoter:
         HFH-3   Sp1   MAZR   STAT5A   FOXL1   YY1   FOXI1   AREB6   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RCN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q22.33-q24.1

RCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCN2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P077223:  view genomic region     (about GC identifiers)

Start:
 77,223,960 bp from pter      End:
 77,242,601 bp from pter
Size:
 18,642 bases      Orientation:
 plus strand

Proteins
for RCN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257 (See protein sequence)
Recommended Name: Reticulocalbin-2 precursor  
Size: 317 amino acids; 36876 Da
Subcellular location: Endoplasmic reticulum lumen
Secondary accessions: A8MTG6 Q53XN8

Explore the universe of human proteins at neXtProt for RCN2: NX_Q14257

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14257

    • RCN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258766.1  NP_002893.1  

    ENSEMBL proteins: 
     ENSP00000378349   ENSP00000319739   ENSP00000378347   ENSP00000453052  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for RCN2 
    GenScript Custom Purified and Recombinant Proteins Services for RCN2
    Novus Biologicals RCN2 Proteins
    Novus Biologicals RCN2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for RCN2
    Uscn Proteins for RCN2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS8034671
    GO:0005788endoplasmic reticulum lumen IEA--


    RCN2 for ontologies           About GeneDecksing



    RCN2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RCN2 
    GenScript Custom Superior Antibodies Services for RCN2
    Novus Biologicals RCN2 Antibodies
    Search for Antibodies for RCN2 at Abcam  
    Uscn Antibodies for RCN2
    Search ThermoFisher Antibodies for RCN2

    Assay Products for RCN2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RCN2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RCN2

    Protein Domains /
    Families
    for RCN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RCN2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q14257

    ProtoNet protein and cluster: Q14257

    UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257
    Similarity: Belongs to the CREC family
    Similarity: Contains 6 EF-hand domains


    Function
    for RCN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257
    Function: Not known. Binds calcium

         Genatlas biochemistry entry for RCN2:
    ERC55 endoplasmic reticulum,lumen protein,55kDa

    miRNA
    Products:            		miRTarBase miRNAs that target RCN2:
    hsa-mir-155 (MIRT001507)

    OriGene 3'-UTR Clone: RCN2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCN2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RCN2 (see all 23):
    hsa-miR-142-5p hsa-miR-320a hsa-miR-485-3p hsa-miR-138-2* hsa-miR-340 hsa-miR-1297 hsa-miR-548m hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmid: RCN2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCN2 (see all 7)
    OriGene shRNA RFP: RCN2
    OriGene siRNA: RCN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCN2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RCN2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCN2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCN2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RCN2 (NM_002902)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCN2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RCN2
    Search LifeMap BioReagents cell lines for RCN2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCN2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--


    RCN2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for RCN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/56 Interacting proteins for RCN2 (Q142572, 3 ENSP000003783494) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-65300 I2D: score=5 
    MAP3K1Q132332, 3MINT-48315 I2D: score=2 
    RIPK1Q135462, 3MINT-49049 I2D: score=2 
    TNFRSF1AP194382, 3MINT-49331 I2D: score=2 
    TNFRSF1BP203332, 3MINT-49419 I2D: score=2 
    About this table

    Drugs & Compounds
    for RCN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RCN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCN2

    1 HMDB Compound for RCN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for RCN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 6 11878933 (3), 8034671 (2)

    Search CenterWatch for drugs/clinical trials and news about RCN2 

    Transcripts
    for RCN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RCN2 gene (2 alternative transcripts): 
    NM_001271837.1  NM_002902.2  

    Unigene Cluster for RCN2:

    Reticulocalbin 2, EF-hand calcium binding domain
    Hs.79088  [show with all ESTs]
    Unigene Representative Sequence: AK126522
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394885(uc002bcd.3) ENST00000320963 ENST00000394883 ENST00000557805
    ENST00000558598 ENST00000560833

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RCN2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCN2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RCN2 (see all 23):
    hsa-miR-142-5p hsa-miR-320a hsa-miR-485-3p hsa-miR-138-2* hsa-miR-340 hsa-miR-1297 hsa-miR-548m hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmid: RCN2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCN2 (see all 7)
    OriGene shRNA RFP: RCN2
    OriGene siRNA: RCN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCN2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCN2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCN2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RCN2 (NM_002902)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCN2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RCN2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RCN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCN2

    Additional cDNA sequence: 

    AK126522.1 AK313833.1 AL110102.1 BC004892.2 BT009790.1 X78669.1 

    16 DOTS entries:

    DT.318622  DT.75190464  DT.100796156  DT.100796151  DT.100796158  DT.121063870  DT.100796144  DT.95156906 
    DT.100669856  DT.100796150  DT.100719096  DT.100796146  DT.100796153  DT.91765927  DT.97777713  DT.91993841 

    24/383 AceView cDNA sequences (see all 383):

    AI270523 AI683921 CD106938 AI935237 AI269468 CA336731 CR610299 BM848289 
    Z39877 BE901570 AL120373 AI380628 AA810637 AA598676 BE910134 AA176692 
    BE503660 CF272200 AA984875 BG390232 AA984929 BM713254 CR595477 CR597519 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RCN2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                                      -     -     -     -     -                       -                     
    SP2:                                      -     -           -     -                                             
    SP3:                                      -     -           -     -                       -                     
    SP4:                                      -           -     -     -                                             
    SP5:                                                                                      -                     


    ECgene alternative splicing isoforms for RCN2

    Expression
    for RCN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGGATTTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RCN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RCN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCN2

    SOURCE GeneReport for Unigene cluster: Hs.79088

    UniProtKB/Swiss-Prot: RCN2_HUMAN, Q14257
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for RCN2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RCN2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RCN2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCN2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCN2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCN2

    Orthologs
    for RCN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RCN2 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RCN21 reticulocalbin 2, EF-hand calcium binding domain 75.14(n)
    74.92(a)    		   415350  XM_413734.3  XP_413734.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RCN26
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343374.1(955152-957362)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.94152 Xenopus laevis transcribed sequence with weak similarity more 77.69(n)    48050237 
    zebrafish
    (Danio rerio)    		 Actinopterygii rcn21 reticulocalbin 2 57.19(n)
    50.17(a)    		   571340  NM_001030263.1  NP_001025434.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG91123
    CG316501    		 calcium ion binding3
    CG316501    		 36(a)3
    48.99(n)1
    36.65(a)1    		   3261501  NM_001169408.11  NP_001162879.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea F08B6.33 EF hand protein 32(a)   I(6766302-6768217)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G277906
    AT5G085806
    		 EF-hand, calcium binding motif-containing protein
    		 20(a)
    17(a)
    		 many ↔ many
    many ↔ many
    		 4(13850046-13851533)
    5(2780512-2783066)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 EF hand family protein, putative, expressed
    calcium-binding EF hand family protein, putative, ...
    (see all 3)    		 20(a)
    18(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 4(34602257-34605106)
    2(6798696-6802474)


    ENSEMBL Gene Tree for RCN2 (if available)
    TreeFam Gene Tree for RCN2 (if available) 

    Paralogs
    for RCN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCN2 gene
    RCN32  RCN12  CALU2  SDF42  
    3 SIMAP similar genes for RCN2 using alignment to 5 protein entries:     RCN2_HUMAN (see all proteins):
    CALU    RCN1    RCN3

    RCN2 for paralogs           About GeneDecksing



    Genomic Variants
    for RCN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/348 NCBI SNPs in RCN2 are shown (see all 348)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1153111741,2
    		F,--77222011(+) TTTAGG/ATAAAT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1411498041,2
    		--77222058(+) CTATAC/TGCTAT 1 -- us2k10--------
    rs1886542941,2
    		--77222072(+) CTTTTA/TTAGGT 1 -- us2k10--------
    rs1928129171,2
    		--77222075(+) TTATAA/GGTCAA 1 -- us2k10--------
    rs1462262371,2
    		--77222124(+) AACAGG/TCTACT 1 -- us2k10--------
    rs1391866571,2
    		--77222154(+) TCCCCC/GAGTAG 1 -- us2k10--------
    rs1425949661,2
    		--77222187(+) ACATTG/TGATCA 1 -- us2k10--------
    rs1853263551,2
    		--77222200(+) CTTGCC/TTCTTT 1 -- us2k10--------
    rs1459889141,2
    		--77222256(+) AAATCA/GTTGAT 1 -- us2k10--------
    rs1396258421,2
    		--77222409(+) ACACAC/TCACTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RCN2 (77223960 - 77242601 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RCN2
         2 CNVs: 4905 3969

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCN2
    DNA2.0 Custom Variant and Variant Library Synthesis for RCN2

    Disorders / Diseases
    for RCN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RCN2 for disorders           About GeneDecksing

    OMIM gene information: 602584    OMIM disorders: --

    8 diseases for RCN2:    About MalaCards
    bardet-biedl syndrome    anogenital venereal wart    absence epilepsy    cervical cancer
    twinning    cervicitis    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RCN2:
    Anogenital venereal wart
    Human Genome Epidemiology (HuGE) Navigator: RCN2 (2 documents)

    Export disorders for RCN2 gene to outside databases

    Publications
    for RCN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCN2 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with RCN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. (PubMed id 8034671)1, 2, 9 Weis K.... Lamond A.I. (1994)
    2. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. (PubMed id 7624774)1, 3, 9 Chen J.J....Androphy E.J. (1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33-->q24.1 by in situ hybridization. (PubMed id 9533013)1, 3 Wang J.Y....Chen J.J. (1997)
    5. Identification and characterization of novel ERC-55 i nteracting proteins: evidence for the existence of several ERC-55 splicing vari ants; including the cytosolic ERC-55-C. (PubMed id 19927312)1, 9 Ludvigsen M....HonorAc B. (2009)
    6. Gene expression analysis in absence epilepsy using a monozygotic twin design. (PubMed id 18435749)1, 9 Helbig I....Hayward N.K. (2008)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for RCN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RCN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5955 HGNC: 9935 AceView: RCN2 Ensembl:ENSG00000117906 euGenes: HUgn5955
    ECgene: RCN2 H-InvDB: RCN2

    Other Databases showing RCN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RCN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCN2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RCN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RCN2 gene:
    Search GeneIP for patents involving RCN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RCN2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RCN2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCN2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RCN2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RCN2   OriGene 3'-UTR Clone for RCN2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCN2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCN2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RCN2   OriGene Custom Protein Services for RCN2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RCN2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCN2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCN2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCN2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCN2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCN2
     GenScript Custom Purified and Recombinant Proteins Services for RCN2 GenScript cDNA clones with any tag delivered in your preferred vector for RCN2
     GenScript Custom Assay Services for RCN2 GenScript Custom Superior Antibodies Services for RCN2
     GenScript Custom overexpressing Cell Line Services for RCN2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RCN2 promoter
     Search Chromatin IP Primers for RCN2
     RT2 qPCR Primer Assay in human, mouse, rat RCN2
     Search GNC Networks for RCN2
     SABiosciences Custom PCR Arrays for RCN2
     Search Tocris compounds for RCN2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RCN2 antibodies
     RCN2 proteins
     RCN2 lysates
     Search for Antibodies for RCN2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RCN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RCN2




     RCN2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RCN2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCN2
     SwitchGear 3'UTR luciferase reporter plasmids for RCN2
     SwitchGear Promoter luciferase reporter plasmids for RCN2
     Search ThermoFisher Antibodies for RCN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCN2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RCN2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4