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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCHY1 Gene

protein-coding   GIFtS: 57
GCID: GC04M076405

ring finger and CHY zinc finger domain containing 1, E3...

(Previous names: zinc finger protein 363, ring finger and CHY zinc finger...)
(Previous symbol: ZNF363)
 Explore 15 diseases affiliated with
RCHY1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RCHY1    

Aliases
for RCHY1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein
Ligase1 2
     DKFZp586C16201
Zinc Finger Protein 3631 2 3     Ring Finger And CHY Zinc Finger Domain Containing 11
ARNIP1 2 3     PIRH2E2
CHIMP1 2 3     PIRH2F2
PIRH21 2 3     Androgen-Receptor N-Terminal-Interacting Protein2
RNF1991 2 3     CH-Rich Interacting Match With PLAG12
ZNF3631 2 3     HARNIP1
PRO19961 2     P53-Induced Protein With A RING-H2 Domain2
E3 Ubiquitin-Protein Ligase Pirh22 3     RING Finger And CHY Zinc Finger Domain-Containing Protein 12
HPirh21     EC 6.3.2.-3
P53-Induced RING-H2 Protein2 3     Androgen Receptor N-Terminal-Interacting Protein3
RING Finger Protein 1992 3     CH-Rich-Interacting Match With PLAG13

External Ids:    HGNC: 174791   Entrez Gene: 258982   Ensembl: ENSG000001637437   OMIM: 6076805   UniProtKB: Q96PM53   
ORGUL members:         
NONCODE:n410666    

Export aliases for RCHY1 gene to outside databases

Previous GC identifers: GC04M076866 GC04M076762 GC04M076623 GC04M072150


Summaries
for RCHY1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RCHY1:
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal
degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle
progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73,
HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH.
Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity

Gene Wiki entry for RCHY1


Genomic Views
for RCHY1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCHY1 gene promoter:
         NF-1/L   NF-1   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RCHY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCHY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCHY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1-q21.3

RCHY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCHY1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076405:  view genomic region     (about GC identifiers)

Start:
 76,404,247 bp from pter      End:
 76,439,974 bp from pter
Size:
 35,728 bases      Orientation:
 minus strand

Proteins
for RCHY1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5 (See protein sequence)
Recommended Name: RING finger and CHY zinc finger domain-containing protein 1  
Size: 261 amino acids; 30110 Da
Subunit: Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and
GORAB/NTKLBP1
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm
Sequence caution: Sequence=BAD92309.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for RCHY1:
2JRJ (3D)        2K2C (3D)        2K2D (3D)    
Secondary accessions: B3KRG3 C7E541 Q2KN33 Q59GN7 Q86X26 Q96PR5
Alternative splicing: 4 isoforms:  Q96PM5-1   Q96PM5-2   Q96PM5-3   Q96PM5-4   (No ubiquitin protein ligase activity. Down-regulated in hepatocellular carcinoma)

Explore the universe of human proteins at neXtProt for RCHY1: NX_Q96PM5

Post-translational modifications:

  • Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96PM5

    • RCHY1 Protein expression data from MOPED and PaxDb:    About this image 
    RCHY1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001008925.1  NP_001009922.1  NP_056251.2  

    ENSEMBL proteins: 
     ENSP00000321239   ENSP00000370220   ENSP00000424631   ENSP00000421958   ENSP00000423976  
     ENSP00000421084   ENSP00000424472   ENSP00000427205   ENSP00000401041  
    Reactome Protein details: Q96PM5
    Human Recombinant Protein Products for RCHY1: 
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    Novus Biologicals RCHY1 Proteins
    Novus Biologicals RCHY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RCHY1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA19043414
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IEA--

    RCHY1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RCHY1

    Protein Domains /
    Families
    for RCHY1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RCHY1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017921 Znf_CTCHY
     IPR004039 Rubredoxin-type_fold
     IPR008913 Znf_CHY

    Graphical View of Domain Structure for InterPro Entry Q96PM5

    ProtoNet protein and cluster: Q96PM5

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB008913 CHY zinc finger


    UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
    Similarity: Contains 1 CHY-type zinc finger
    Similarity: Contains 1 CTCHY-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RCHY1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN363_HUMAN, Q96PM5
    Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73,
    HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH.
    Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity
    Induction: Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI19043414
    GO:0004842ubiquitin-protein ligase activity IDA19483087
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IDA19043414
         
    RCHY1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RCHY1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rchy1):
     cellular 

    RCHY1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Rchy1tm1.1Raz for RCHY1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RCHY1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCHY1
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    hsa-miR-361-5p hsa-miR-938 hsa-miR-3074-3p hsa-miR-519a hsa-miR-500a hsa-miR-550a* hsa-miR-4274 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: RCHY1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCHY1 (see all 7)
    OriGene shRNA RFP: RCHY1
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCHY1


    Pathways & Interactions
    for RCHY1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3Protein Stability
    		Protein Stability1.00
    4Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    5p53 pathway
    		p53 pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RCHY1
        Cell Cycle / Checkpoint Control
    Protein Stability

    3 BioSystems Pathways for RCHY1 
        Regulation of Androgen receptor activity
    p53 pathway
    Direct p53 effectors

    5        Reactome Pathways for RCHY1
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    3         Kegg Pathways  (Kegg details for RCHY1):
        p53 signaling pathway
    Ubiquitin mediated proteolysis
    Measles

    UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
    Pathway: Protein modification; protein ubiquitination


    RCHY1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RCHY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for RCHY1 (Q96PM51, 2, 3 ENSP000003212394) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-5114673 MINT-5114627 MINT-5114708 MINT-5114653 MINT-5114724 I2D: score=4 STRING: ENSP00000269305
    CALM2P621582, 3MINT-5114562 MINT-5114545 I2D: score=2 
    CALM3P621582, 3MINT-5114562 MINT-5114545 I2D: score=2 
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2871724 I2D: score=3 STRING: ENSP00000344782
    CAMK2AQ9UQM72, 3, ENSP000003814124MINT-5114580 I2D: score=2 STRING: ENSP00000381412
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IDA19043414
    GO:0031398positive regulation of protein ubiquitination IDA19483087
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA19483087
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA19483087
    GO:0051865protein autoubiquitination IDA19483087

    RCHY1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RCHY1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCHY1
    Search CenterWatch for drugs/clinical trials and news about RCHY1 / ZN363 

    Transcripts
    for RCHY1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RCHY1 gene (3 alternative transcripts): 
    NM_001008925.2  NM_001009922.2  NM_015436.3  

    Unigene Cluster for RCHY1:

    Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
    Hs.48297  [show with all ESTs]
    Unigene Representative Sequence: NR_037913
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324439(uc010iio.3 uc003hij.3 uc003hik.3 uc021xpe.1 uc010iiq.3 uc003hil.3 uc010iip.3 uc010iir.3)
    ENST00000380840 ENST00000514589 ENST00000505105 ENST00000512567 ENST00000504085
    ENST00000512706 ENST00000513257 ENST00000507014 ENST00000513909 ENST00000505514
    ENST00000513083 ENST00000514021 ENST00000451788

    miRNA
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    hsa-miR-361-5p hsa-miR-938 hsa-miR-3074-3p hsa-miR-519a hsa-miR-500a hsa-miR-550a* hsa-miR-4274 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: RCHY1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB209072.1 AF247041.1 AF255666.1 AF305424.1 AK091501.1 AK308754.1 AK308848.1 AK309555.1 
    AL050144.1 AY888047.1 BC015464.1 BC047393.1 GQ250944.1 GQ250945.1 GQ250946.1 GU937000.1 
    JF691538.1 JF691539.1 NR_037913.1 NR_037914.1 

    6 DOTS entries:

    DT.210686  DT.100774661  DT.99959791  DT.100725588  DT.115270  DT.92432930 

    24/175 AceView cDNA sequences (see all 175):

    CR612839 CB119489 H30832 CR596363 AI423080 BF196678 AA831228 AL050144 
    BM698306 BQ959587 BX459245 CN483543 CR598430 H73931 AI193812 AA324462 
    AL120684 AA370903 AF247041 BC015464 BI756231 BF940770 BQ669477 AA886467 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RCHY1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                    -               
    SP2:                          -                                                         
    SP3:                                                                                    
    SP4:                    -     -                                                         
    SP5:                          -                                                         


    ECgene alternative splicing isoforms for RCHY1

    Expression
    for RCHY1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCHY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCTTTGCT
    RCHY1 Expression
    About this image
    See RCHY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCHY1

    SOURCE GeneReport for Unigene cluster: Hs.48297
        SABiosciences Expression via Pathway-Focused PCR Array including RCHY1: 

              Ubiquitin Ligases in human mouse rat

    Primer
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    Orthologs
    for RCHY1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RCHY1 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rchy11 , 5 ring finger and CHY zinc finger domain containing 11, 5 88.25(n)1
    90.42(a)1    		   5 (45.58 cM)5
    680981  NM_026557.31  NP_080833.11 
     919489045 
    chicken
    (Gallus gallus)    		 Aves RCHY11 ring finger and CHY zinc finger domain containing 1 71.88(n)
    81.07(a)    		   771726  NM_001080888.1  NP_001074357.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.106072 Transcribed sequence with weak similarity to protein more 76.25(n)    137710299 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF262047.12   -- 78.67(n)    AF262047.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG169471 CG16947 53.19(n)
    50.42(a)    		   33901  NM_135186.1  NP_609030.1 
    K. lactis yeast
    (Kluyveromyces lactis)    		 Saccharomycetes KLLA0E18503g1 hypothetical protein 50.35(n)
    44.68(a)    		   2894478  XM_454787.1  XP_454787.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G629701 ring finger and CHY zinc finger domain-containing protein more 54.99(n)
    49.21(a)    		   825472  NM_116162.5  NP_191856.4 
    rice
    (Oryza sativa)    		 Liliopsida Os12g05385001 hypothetical protein 53.1(n)
    48.05(a)    		   4352424  NM_001073473.1  NP_001066941.1 


    ENSEMBL Gene Tree for RCHY1 (if available)
    TreeFam Gene Tree for RCHY1 (if available) 

    Paralogs
    for RCHY1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RCHY1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/528 NCBI SNPs in RCHY1 are shown (see all 528)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs772631411,2
    		C--72150949(+) CAAAAC/GATCAC 5 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.12WA 120
    rs728662101,2
    		C--72150961(+) TTGTAC/TTCCAT 5 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.18WA 120
    rs1154204431,2
    		C,F--72151919(+) TAAGTG/ACATGA 5 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.02WA 118
    rs1123595341,2
    		C--72152747(+) AAACTA/GGTCTT 5 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.02NA 122
    rs728662141,2
    		C--72153283(+) CCATCC/TCCTAT 5 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50WA 2
    rs1157110021,2
    		C,F--72153519(+) GACTCT/CTTGAA 5 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.03WA 118
    rs76985551,2
    		C,F,H--72153678(+) GAACTG/AATGAT 5 -- ut31 nc-transcript-variant12Minor allele frequency- A:0.06NS EA NA WA 1314
    rs91891,2
    		F--72153940(+) GCACGC/TGTAGT 5 -- ut31 nc-transcript-variantese34Minor allele frequency- T:0.02MN CSA WA 308
    rs37755321,2
    		C,F,H--72153941(-) CACTAC/TGCGTG 5 -- ut31 nc-transcript-variantese35Minor allele frequency- T:0.01NS EA 538
    rs728662151,2
    		C--72154490(+) AAAGAT/GGTGAA 5 -- int12Minor allele frequency- G:0.15WA 120

    HapMap Linkage Disequilibrium report for RCHY1 (76404247 - 76439974 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RCHY1: --

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    Disorders / Diseases
    for RCHY1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RCHY1 for disorders           About GeneDecksing

    OMIM gene information: 607680    OMIM disorders: --

    15 diseases for RCHY1:    About MalaCards
    renovascular hypertension    monkeypox    fanconi's anemia    measles
    anemia    hypertension    hepatocellular carcinoma    lung carcinoma
    lung cancer    prostate cancer    breast cancer    ataxia
    carcinoma    prostatitis    hepatitis

    2 Novoseek disease relationships for RCHY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 21.9 8 17686242 (5), 16934800 (1)
    tumors 11.2 5 16934800 (2), 17568776 (2)


    Export disorders for RCHY1 gene to outside databases

    Publications
    for RCHY1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCHY1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with RCHY1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PubMed id 17950244)1, 2, 9 Zheng G....Yang Y.C. (2007)
    2. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. (PubMed id 12654245)1, 3, 9 Leng R.P....Benchimol S. (2003)
    3. Molecular basis of Pirh2-mediated p53 ubiquitylation. (PubMed id 19043414)1, 2, 9 Sheng Y.... Arrowsmith C.H. (2008)
    4. Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. (PubMed id 14701804)1, 2, 9 Logan I.R.... Robson C.N. (2004)
    5. Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination. (PubMed id 21994467)1, 2 Wu H.... Leng R.P. (2011)
    6. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polym erase eta to suppress translesion DNA synthesis. (PubMed id 21791603)1, 2 Jung Y.S....Chen X. (2011)
    7. A novel hPirh2 splicing variant without ubiquitin pro tein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma. (PubMed id 20452352)1, 2 Wu G....Huo K. (2010)
    8. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. (PubMed id 19483087)1, 2 Corcoran C.A.... Sheikh M.S. (2009)
    9. Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. (PubMed id 17721809)1, 2 Maruyama S....Hatakeyama S. (2008)
    10. Pirh2 promotes ubiquitin-dependent degradation of the cyclin- dependent kinase inhibitor p27Kip1. (PubMed id 18006823)1, 2 Hattori T.... Kitagawa M. (2007)

    External Searches for RCHY1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RCHY1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25898 HGNC: 17479 AceView: RCHY1 Ensembl:ENSG00000163743 euGenes: HUgn25898
    ECgene: RCHY1 Kegg: 25898 H-InvDB: RCHY1

    Other Databases showing RCHY1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RCHY1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCHY1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCHY1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RCHY1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RCHY1 gene:
    Search GeneIP for patents involving RCHY1

    GeneCards and IP:
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