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RCHY1 Gene

protein-coding   GIFtS: 60
GCID: GC04M076405

Ring Finger And CHY Zinc Finger Domain Containing 1, E3...

(Previous names: zinc finger protein 363, ring finger and CHY zinc finger...)
(Previous symbol: ZNF363)
  Search for RCHY1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin
Protein Ligase1 2
     Ring Finger And CHY Zinc Finger Domain Containing 11
Zinc Finger Protein 3631 2 3     Zinc Finger1
ZNF3631 2 3     PRO19962
Androgen-Receptor N-Terminal-Interacting Protein1 2     ZCHY2
P53-Induced Protein With A RING-H2 Domain1 2     CH-Rich Interacting Match With PLAG12
ARNIP2 3     RING Finger And CHY Zinc Finger Domain-Containing Protein 12
CHIMP2 3     Zinc Finger, CHY-Type2
PIRH22 3     EC 6.3.2.-3
RNF1992 3     Androgen Receptor N-Terminal-Interacting Protein3
E3 Ubiquitin-Protein Ligase Pirh22 3     CH-Rich-Interacting Match With PLAG13
RING Finger Protein 1992 3     hPirh23
CHY-type1     P53-Induced RING-H2 Protein3

External Ids:    HGNC: 174791   Entrez Gene: 258982   Ensembl: ENSG000001637437   OMIM: 6076805   UniProtKB: Q96PM53   
ORGUL members:         

Export aliases for RCHY1 gene to outside databases

Previous GC identifers: GC04M076866 GC04M076762 GC04M076623 GC04M072150


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RCHY1 Gene:
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and
proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and
cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively
spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq,
Jun 2013)

GeneCards Summary for RCHY1 Gene:
RCHY1 (ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53,
P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA
polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor
activity

Gene Wiki entry for RCHY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RCHY1 gene promoter:
         NF-1/L   NF-1   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCHY1 promoter sequence
   Search Chromatin IP Primers for RCHY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RCHY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1-q21.3

RCHY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCHY1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076405:  view genomic region     (about GC identifiers)

Start:
76,404,247 bp from pter      End:
76,439,974 bp from pter
Size:
35,728 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5 (See protein sequence)
Recommended Name: RING finger and CHY zinc finger domain-containing protein 1  
Size: 261 amino acids; 30110 Da
Subunit: Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE,
UBE2D2 and GORAB/NTKLBP1
Sequence caution: Sequence=BAD92309.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for RCHY1:
2JRJ (3D)        2K2C (3D)        2K2D (3D)    
Secondary accessions: B3KRG3 C7E541 C7E542 C7E543 D3YRV2 E7EMC8 E7ETW5 J3KPI0 Q2KN33 Q59GN7
Q86X26 Q96PR5
Alternative splicing: 8 isoforms:  Q96PM5-1   Q96PM5-2   Q96PM5-3   Q96PM5-4   Q96PM5-5   Q96PM5-6   Q96PM5-7   Q96PM5-8   
(No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for RCHY1: NX_Q96PM5

Explore proteomics data for RCHY1 at MOPED

Post-translational modifications: 

  • Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability1
  • Ubiquitination2 at Lys241
  • Modification sites at PhosphoSitePlus

  • See RCHY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001009922.1  NP_001265465.1  NP_001265466.1  NP_001265467.1  NP_001265468.1  NP_056251.2  

    ENSEMBL proteins: 
     ENSP00000321239   ENSP00000370220   ENSP00000424631   ENSP00000421958   ENSP00000423976  
     ENSP00000421084   ENSP00000424472   ENSP00000427205   ENSP00000401041  
    Reactome Protein details: Q96PM5

    RCHY1 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017921 Znf_CTCHY
     IPR004039 Rubredoxin-type_fold
     IPR008913 Znf_CHY

    Graphical View of Domain Structure for InterPro Entry Q96PM5

    ProtoNet protein and cluster: Q96PM5

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB008913 CHY zinc finger


    UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
    Similarity: Contains 1 CHY-type zinc finger
    Similarity: Contains 1 CTCHY-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RCHY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN363_HUMAN, Q96PM5
    Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53,
    P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA
    polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor
    activity
    Induction: Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI19043414
    GO:0004842ubiquitin-protein ligase activity IDA19483087
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI15781263
    GO:0008270zinc ion binding IDA19043414
         
    Find genes that share ontologies with RCHY1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RCHY1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rchy1):
     cellular 

    Find genes that share phenotypes with RCHY1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rchy1tm1.1Raz for RCHY1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RCHY1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RCHY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCHY1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCHY1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RCHY1 (see all 49):
    hsa-miR-361-5p hsa-miR-938 hsa-miR-3074-3p hsa-miR-519a hsa-miR-500a hsa-miR-550a* hsa-miR-4274 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidRCHY1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RCHY1

    Gene Editing
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    Addgene plasmids for RCHY1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN363_HUMAN, Q96PM5: Nucleus. Nucleus speckle. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA19043414
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with RCHY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RCHY1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2p53 signaling pathway
    p53 signaling pathway0.41
    3Influenza A
    Measles0.34
    4Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    5Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity


    Find genes that share SuperPaths with RCHY1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RCHY1
        Cell Cycle / Checkpoint Control
    Protein Stability

    3 BioSystems Pathways for RCHY1
        Direct p53 effectors
    Regulation of Androgen receptor activity
    p53 pathway


    1 Reactome Pathway for RCHY1
        Antigen processing: Ubiquitination & Proteasome degradation


    3 Kegg Pathways  (Kegg details for RCHY1):
        p53 signaling pathway
    Ubiquitin mediated proteolysis
    Measles

    UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including RCHY1: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RCHY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RCHY1 (Q96PM51, 2, 3 ENSP000003212394) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-947779,EBI-366083 MINT-5114673 MINT-5114627 MINT-5114708 MINT-5114653 MINT-5114724 I2D: score=4 STRING: ENSP00000269305
    CALM2P621581, 2, 3EBI-947779,EBI-397435 MINT-5114562 MINT-5114545 I2D: score=2 
    CALM3P621581, 2, 3EBI-947779,EBI-397435 MINT-5114562 MINT-5114545 I2D: score=2 
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2871724 I2D: score=3 STRING: ENSP00000344782
    CAMK2AQ9UQM72, 3, ENSP000003814124MINT-5114580 I2D: score=2 STRING: ENSP00000381412
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IDA19043414
    GO:0031398positive regulation of protein ubiquitination IDA19483087
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA19483087
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA19483087
    GO:0051865protein autoubiquitination IDA19483087

    Find genes that share ontologies with RCHY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RCHY1 (ZN363)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RCHY1 gene (7 alternative transcripts): 
    NM_001009922.2  NM_001278536.1  NM_001278537.1  NM_001278538.1  NM_001278539.1  NM_015436.3  NM_001008925.2  

    Unigene Cluster for RCHY1:

    Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
    Hs.48297  [show with all ESTs]
    Unigene Representative Sequence: NR_037913
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324439(uc010iio.3 uc003hij.3 uc003hik.3 uc021xpe.1 uc010iiq.3 uc003hil.3 uc010iip.3 uc010iir.3)
    ENST00000380840 ENST00000505105 ENST00000514589 ENST00000512567 ENST00000504085
    ENST00000512706 ENST00000513257 ENST00000507014 ENST00000513909 ENST00000505514
    ENST00000513083 ENST00000514021 ENST00000451788
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    hsa-miR-361-5p hsa-miR-938 hsa-miR-3074-3p hsa-miR-519a hsa-miR-500a hsa-miR-550a* hsa-miR-4274 hsa-miR-23a
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      QuantiFast Probe-based Assays in human, mouse, rat RCHY1

    Additional mRNA sequence: 

    AB209072.1 AF247041.1 AF255666.1 AF305424.1 AK091501.1 AK308754.1 AK308848.1 AK309555.1 
    AL050144.1 AY888047.1 BC015464.1 BC047393.1 GQ250944.1 GQ250945.1 GQ250946.1 GU937000.1 
    JF691538.1 JF691539.1 NR_037913.1 NR_037914.1 

    6 DOTS entries:

    DT.210686  DT.100774661  DT.99959791  DT.100725588  DT.115270  DT.92432930 

    Selected AceView cDNA sequences (see all 175):

    CB119489 AI096477 BQ959587 CR598430 AA831228 AI193812 AW236209 AA324462 
    H73931 AL050144 AA370903 AA886467 AF247041 AI423080 BF940770 BX459245 
    BI756231 CN483543 BQ669477 AL120684 AI718413 BM698306 BF196678 CR612839 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RCHY1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                    -               
    SP2:                          -                                                         
    SP3:                                                                                    
    SP4:                    -     -                                                         
    SP5:                          -                                                         


    ECgene alternative splicing isoforms for RCHY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RCHY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTTTGCT
    RCHY1 Expression
    About this image

    RCHY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RCHY1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48297
        Pathway & Disease-focused RT2 Profiler PCR Array including RCHY1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RCHY1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rchy11 , 5 ring finger and CHY zinc finger domain containing 11, 5 88.25(n)1
    90.42(a)1
      5 (45.58 cM)5
    680981  NM_026557.41  NP_080833.11 
     919489045 
    chicken
    (Gallus gallus)
    Aves RCHY11 ring finger and CHY zinc finger domain containing 1, more 70.65(n)
    78.49(a)
      771726  NM_001080888.1  NP_001074357.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.106072 Transcribed sequence with weak similarity to protein more 76.25(n)    137710299 
    zebrafish
    (Danio rerio)
    Actinopterygii AF262047.12   -- 78.67(n)    AF262047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169471 CG16947 53.19(n)
    50.42(a)
      33901  NM_135186.2  NP_609030.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G629701 AT3G62970 54.99(n)
    49.21(a)
      825472  NM_116162.5  NP_191856.4 
    rice
    (Oryza sativa)
    Liliopsida Os12g05385001 Os12g0538500 53.1(n)
    48.05(a)
      4352424  NM_001073473.1  NP_001066941.1 


    ENSEMBL Gene Tree for RCHY1 (if available)
    TreeFam Gene Tree for RCHY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RCHY1 gene
    1 SIMAP similar gene for RCHY1 using alignment to 7 protein entries:     ZN363_HUMAN (see all proteins):
    DKFZp586C1620

    Find genes that share paralogs with RCHY1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RCHY1 (see all 663)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488175151,2
    C--76222537(+) TAAAA-/AA    
       AAAAC
    CAGCC
    5 -- ds50010--------
    rs15802971,2
    C,F,A,H--76222544(-) taataC/Ttggct 5 -- ds500116Minor allele frequency- T:0.31NS EA WA NA CSA 754
    rs126449111,2
    C,F,H--76222829(+) gaagaC/Tattat 5 -- ds50016Minor allele frequency- T:0.21NA CSA WA EA 364
    rs1887734241,2
    --76222841(+) CTAAAC/TGAAAT 5 -- ds50010--------
    rs1811495681,2
    --76223094(+) AAGAGC/TAGATT 5 -- ut31 nc-transcript-variant0--------
    rs1861307701,2
    --76223149(+) TTATTA/GCATTG 5 -- ut31 nc-transcript-variant0--------
    rs772631411,2
    C,F--76223190(+) CAAAAC/GATCAC 5 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.12WA 120
    rs728662101,2
    C,F--76223202(+) TTGTAC/TTCCAT 5 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.18WA 120
    rs678911241,2
    C,F--76223262(+) AAGAA-/AAA/
    AAT
    /TAAA
    AAAGT
    15 -- ut31 cds1 nc-transcript-variant2NA 4
    rs571298621,2
    C--76223265(+) AAAAATAAA/-  
            
    GTGGC
    5 -- ut31 nc-transcript-variant1Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for RCHY1 (76404247 - 76439974 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RCHY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7363OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RCHY1
    DNA2.0 Custom Variant and Variant Library Synthesis for RCHY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607680    OMIM disorders: --


    Find genes that share disorders with RCHY1           About GenesLikeMe

    2 Novoseek inferred disease relationships for RCHY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 21.9 8 17686242 (5), 16934800 (1)
    tumors 11.2 5 16934800 (2), 17568776 (2)

    Genetic Association Database (GAD): RCHY1

    Export disorders for RCHY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RCHY1 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with RCHY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PubMed id 17950244)1, 2, 9 Zheng G.... Yang Y.-C. (Biochem. Biophys. Res. Commun. 2007)
    2. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. (PubMed id 12654245)1, 3, 9 Leng R.P....Benchimol S. (Cell 2003)
    3. Molecular basis of Pirh2-mediated p53 ubiquitylation. (PubMed id 19043414)1, 2, 9 Sheng Y.... Arrowsmith C.H. (Nat. Struct. Mol. Biol. 2008)
    4. Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. (PubMed id 14701804)1, 2, 9 Logan I.R.... Robson C.N. (J. Biol. Chem. 2004)
    5. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1, 4 Wang J....Platt A. (Pharmacogenomics J. 2013)
    6. Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination. (PubMed id 21994467)1, 2 Wu H.... Leng R.P. (Mol. Cancer Res. 2011)
    7. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. (PubMed id 21791603)1, 2 Jung Y.S.... Chen X. (Mol. Cell. Biol. 2011)
    8. A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma. (PubMed id 20452352)1, 2 Wu G.... Huo K. (FEBS Lett. 2010)
    9. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. (PubMed id 19483087)1, 2 Corcoran C.A.... Sheikh M.S. (J. Biol. Chem. 2009)
    10. Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. (PubMed id 17721809)1, 2 Maruyama S.... Hatakeyama S. (Mol. Cell. Biochem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25898 HGNC: 17479 AceView: RCHY1 Ensembl:ENSG00000163743 euGenes: HUgn25898
    ECgene: RCHY1 Kegg: 25898 H-InvDB: RCHY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RCHY1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCHY1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RCHY1 gene:
    Search GeneIP for patents involving RCHY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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