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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCHY1 Gene

protein-coding   GIFtS: 60
GCID: GC04M076405

Ring Finger And CHY Zinc Finger Domain Containing 1, E3...

(Previous names: zinc finger protein 363, ring finger and CHY zinc finger...)
(Previous symbol: ZNF363)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin
Protein Ligase1 2
     RING Finger Protein 1992 3
Zinc Finger Protein 3631 2 3     Ring Finger And CHY Zinc Finger Domain Containing 11
ZNF3631 2 3     PRO19962
Androgen-Receptor N-Terminal-Interacting Protein1 2     CH-Rich Interacting Match With PLAG12
P53-Induced Protein With A RING-H2 Domain1 2     RING Finger And CHY Zinc Finger Domain-Containing Protein 12
ARNIP2 3     EC 6.3.2.-3
CHIMP2 3     Androgen Receptor N-Terminal-Interacting Protein3
PIRH22 3     CH-Rich-Interacting Match With PLAG13
RNF1992 3     hPirh23
E3 Ubiquitin-Protein Ligase Pirh22 3     P53-Induced RING-H2 Protein3

External Ids:    HGNC: 174791   Entrez Gene: 258982   Ensembl: ENSG000001637437   OMIM: 6076805   UniProtKB: Q96PM53   
ORGUL members:         
NONCODE14:n410666      

Export aliases for RCHY1 gene to outside databases

Previous GC identifers: GC04M076866 GC04M076762 GC04M076623 GC04M072150


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCHY1 Gene:
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and
proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and
cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively
spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq,
Jun 2013)

GeneCards Summary for RCHY1 Gene: 
RCHY1 (ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RCHY1 include monkeypox, and renovascular hypertension, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53,
P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA
polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor
activity

Gene Wiki entry for RCHY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCHY1 gene promoter:
         NF-1/L   NF-1   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCHY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCHY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCHY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1-q21.3

RCHY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCHY1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076405:  view genomic region     (about GC identifiers)

Start:
76,404,247 bp from pter      End:
76,439,974 bp from pter
Size:
35,728 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5 (See protein sequence)
Recommended Name: RING finger and CHY zinc finger domain-containing protein 1  
Size: 261 amino acids; 30110 Da
Subunit: Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE,
UBE2D2 and GORAB/NTKLBP1
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm
Sequence caution: Sequence=BAD92309.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for RCHY1:
2JRJ (3D)        2K2C (3D)        2K2D (3D)    
Secondary accessions: B3KRG3 C7E541 Q2KN33 Q59GN7 Q86X26 Q96PR5
Alternative splicing: 4 isoforms:  Q96PM5-1   Q96PM5-2   Q96PM5-3   Q96PM5-4   (No ubiquitin protein ligase activity. Down-regulated in hepatocellular carcinoma)

Explore the universe of human proteins at neXtProt for RCHY1: NX_Q96PM5

Explore proteomics data for RCHY1 at MOPED 

Post-translational modifications:

  • UniProtKB: Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PM5

  • RCHY1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCHY1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001009922.1  NP_001265465.1  NP_001265466.1  NP_001265467.1  NP_001265468.1  NP_056251.2  

    ENSEMBL proteins: 
     ENSP00000321239   ENSP00000370220   ENSP00000424631   ENSP00000421958   ENSP00000423976  
     ENSP00000421084   ENSP00000424472   ENSP00000427205   ENSP00000401041  
    Reactome Protein details: Q96PM5
    Human Recombinant Protein Products for RCHY1: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA19043414
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IEA--

    RCHY1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017921 Znf_CTCHY
     IPR004039 Rubredoxin-type_fold
     IPR008913 Znf_CHY

    Graphical View of Domain Structure for InterPro Entry Q96PM5

    ProtoNet protein and cluster: Q96PM5

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB008913 CHY zinc finger


    UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
    Similarity: Contains 1 CHY-type zinc finger
    Similarity: Contains 1 CTCHY-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    RCHY1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN363_HUMAN, Q96PM5
    Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53,
    P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA
    polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor
    activity
    Induction: Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI19043414
    GO:0004842ubiquitin-protein ligase activity IDA19483087
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI15781263
    GO:0008270zinc ion binding IDA19043414
         
    RCHY1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RCHY1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rchy1):
     cellular 

    RCHY1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rchy1tm1.1Raz for RCHY1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCHY1 
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    hsa-miR-361-5p hsa-miR-938 hsa-miR-3074-3p hsa-miR-519a hsa-miR-500a hsa-miR-550a* hsa-miR-4274 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidRCHY1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RCHY1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3p53 signaling pathway
    p53 signaling pathway0.41
    4Influenza A
    Measles0.34
    5DNA Damage
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RCHY1
        Cell Cycle / Checkpoint Control
    Protein Stability

    3 BioSystems Pathways for RCHY1
        Regulation of Androgen receptor activity
    p53 pathway
    Direct p53 effectors


    4        Reactome Pathways for RCHY1
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    3         Kegg Pathways  (Kegg details for RCHY1):
        p53 signaling pathway
    Ubiquitin mediated proteolysis
    Measles

    UniProtKB/Swiss-Prot: ZN363_HUMAN, Q96PM5
    Pathway: Protein modification; protein ubiquitination


    RCHY1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RCHY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for RCHY1 (Q96PM51, 2, 3 ENSP000003212394) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-5114673 MINT-5114627 MINT-5114708 MINT-5114653 MINT-5114724 I2D: score=4 STRING: ENSP00000269305
    CALM2P621582, 3MINT-5114562 MINT-5114545 I2D: score=2 
    CALM3P621582, 3MINT-5114562 MINT-5114545 I2D: score=2 
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2871724 I2D: score=3 STRING: ENSP00000344782
    CAMK2AQ9UQM72, 3, ENSP000003814124MINT-5114580 I2D: score=2 STRING: ENSP00000381412
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IDA19043414
    GO:0031398positive regulation of protein ubiquitination IDA19483087
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA19483087
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA19483087
    GO:0051865protein autoubiquitination IDA19483087

    RCHY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCHY1 (ZN363)

    Search CenterWatch for drugs/clinical trials and news about RCHY1 / ZN363

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCHY1 gene (7 alternative transcripts): 
    NM_001009922.2  NM_001278536.1  NM_001278537.1  NM_001278538.1  NM_001278539.1  NM_015436.3  NM_001008925.2  

    Unigene Cluster for RCHY1:

    Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
    Hs.48297  [show with all ESTs]
    Unigene Representative Sequence: NR_037913
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324439(uc010iio.3 uc003hij.3 uc003hik.3 uc021xpe.1 uc010iiq.3 uc003hil.3 uc010iip.3 uc010iir.3)
    ENST00000380840 ENST00000505105 ENST00000514589 ENST00000512567 ENST00000504085
    ENST00000512706 ENST00000513257 ENST00000507014 ENST00000513909 ENST00000505514
    ENST00000513083 ENST00000514021 ENST00000451788
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    Additional mRNA sequence: 

    AB209072.1 AF247041.1 AF255666.1 AF305424.1 AK091501.1 AK308754.1 AK308848.1 AK309555.1 
    AL050144.1 AY888047.1 BC015464.1 BC047393.1 GQ250944.1 GQ250945.1 GQ250946.1 GU937000.1 
    JF691538.1 JF691539.1 NR_037913.1 NR_037914.1 

    6 DOTS entries:

    DT.210686  DT.100774661  DT.99959791  DT.100725588  DT.115270  DT.92432930 

    24/175 AceView cDNA sequences (see all 175):

    CR598430 BM698306 BC015464 H73931 CN483543 AF247041 AI193812 BX459245 
    AW128845 AW236209 BF940770 AA370903 BQ959587 H30832 AI423080 AA831228 
    BQ669477 CR596363 CB119489 AI096477 AA886467 AI718413 AL120684 BI756231 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RCHY1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                    -               
    SP2:                          -                                                         
    SP3:                                                                                    
    SP4:                    -     -                                                         
    SP5:                          -                                                         


    ECgene alternative splicing isoforms for RCHY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCHY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTTTGCT
    RCHY1 Expression
    About this image


    See RCHY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCHY1

    SOURCE GeneReport for Unigene cluster: Hs.48297
        SABiosciences Expression via Pathway-Focused PCR Array including RCHY1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RCHY1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rchy11 , 5 ring finger and CHY zinc finger domain containing 11, 5 88.25(n)1
    90.42(a)1
      5 (45.58 cM)5
    680981  NM_026557.31  NP_080833.11 
     919489045 
    chicken
    (Gallus gallus)
    Aves RCHY11 ring finger and CHY zinc finger domain containing 1 71.88(n)
    81.07(a)
      771726  NM_001080888.1  NP_001074357.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.106072 Transcribed sequence with weak similarity to protein more 76.25(n)    137710299 
    zebrafish
    (Danio rerio)
    Actinopterygii AF262047.12   -- 78.67(n)    AF262047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169471 CG16947 53.19(n)
    50.42(a)
      33901  NM_135186.1  NP_609030.1 
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0E18503g1 hypothetical protein 50.35(n)
    44.68(a)
      2894478  XM_454787.1  XP_454787.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G629701 ring finger and CHY zinc finger domain-containing protein more 54.99(n)
    49.21(a)
      825472  NM_116162.5  NP_191856.4 
    rice
    (Oryza sativa)
    Liliopsida Os12g05385001 hypothetical protein 53.1(n)
    48.05(a)
      4352424  NM_001073473.1  NP_001066941.1 


    ENSEMBL Gene Tree for RCHY1 (if available)
    TreeFam Gene Tree for RCHY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCHY1 gene
    1 SIMAP similar gene for RCHY1 using alignment to 13 protein entries:     ZN363_HUMAN (see all proteins):
    DKFZp586C1620

    RCHY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/663 SNPs in RCHY1 are shown (see all 663)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488175151,2
    C--76222537(+) TAAAA-/AA    
       AAAAC
    CAGCC
    5 -- ds50010--------
    rs15802971,2
    C,F,A,H--76222544(-) taataC/Ttggct 5 -- ds500116Minor allele frequency- T:0.31NS EA WA NA CSA 754
    rs126449111,2
    C,F,H--76222829(+) gaagaC/Tattat 5 -- ds50016Minor allele frequency- T:0.21NA CSA WA EA 364
    rs1887734241,2
    --76222841(+) CTAAAC/TGAAAT 5 -- ds50010--------
    rs1811495681,2
    --76223094(+) AAGAGC/TAGATT 5 -- ut31 nc-transcript-variant0--------
    rs1861307701,2
    --76223149(+) TTATTA/GCATTG 5 -- ut31 nc-transcript-variant0--------
    rs772631411,2
    C,F--76223190(+) CAAAAC/GATCAC 5 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.12WA 120
    rs728662101,2
    C,F--76223202(+) TTGTAC/TTCCAT 5 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.18WA 120
    rs678911241,2
    C,F--76223262(+) AAGAA-/AAA/
    AAT
    /TAAA
    AAAGT
    15 -- ut31 cds1 nc-transcript-variant2NA 4
    rs571298621,2
    C--76223265(+) AAAAATAAA/-  
            
    GTGGC
    5 -- ut31 nc-transcript-variant1Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for RCHY1 (76404247 - 76439974 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RCHY1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7363OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607680    OMIM disorders: --

    14 diseases for RCHY1:    About MalaCards
    monkeypox    renovascular hypertension    measles    fanconi's anemia
    anemia    hypertension    hepatocellular carcinoma    lung cancer
    rheumatoid arthritis    prostate cancer    arthritis    prostatitis
    hepatitis    breast cancer


    RCHY1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RCHY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 21.9 8 17686242 (5), 16934800 (1)
    tumors 11.2 5 16934800 (2), 17568776 (2)

    Genetic Association Database (GAD): RCHY1

    Export disorders for RCHY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCHY1 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with RCHY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PubMed id 17950244)1, 2, 9 Zheng G....Yang Y.C. (2007)
    2. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. (PubMed id 12654245)1, 3, 9 Leng R.P....Benchimol S. (2003)
    3. Molecular basis of Pirh2-mediated p53 ubiquitylation. (PubMed id 19043414)1, 2, 9 Sheng Y.... Arrowsmith C.H. (2008)
    4. Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. (PubMed id 14701804)1, 2, 9 Logan I.R.... Robson C.N. (2004)
    5. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1, 4 Wang J....Platt A. (2012)
    6. Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination. (PubMed id 21994467)1, 2 Wu H.... Leng R.P. (2011)
    7. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polym erase eta to suppress translesion DNA synthesis. (PubMed id 21791603)1, 2 Jung Y.S....Chen X. (2011)
    8. A novel hPirh2 splicing variant without ubiquitin pro tein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma. (PubMed id 20452352)1, 2 Wu G....Huo K. (2010)
    9. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. (PubMed id 19483087)1, 2 Corcoran C.A.... Sheikh M.S. (2009)
    10. Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. (PubMed id 17721809)1, 2 Maruyama S....Hatakeyama S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25898 HGNC: 17479 AceView: RCHY1 Ensembl:ENSG00000163743 euGenes: HUgn25898
    ECgene: RCHY1 Kegg: 25898 H-InvDB: RCHY1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCHY1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCHY1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCHY1 gene:
    Search GeneIP for patents involving RCHY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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