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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCE1 Gene

protein-coding   GIFtS: 59
GCID: GC11P066611

RCE1 Homolog, Prenyl Protein Protease (S. Cerevisiae)

(Previous names: RCE1 (S. Cerevisiae) homolog, prenyl protein protease, RCE1...)
(Previous symbols: RCE1A, RCE1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RCE1 Homolog, Prenyl Protein Protease (S. Cerevisiae)1 2     FACE22 3
RCE1A1 2 3     Prenyl Protein Protease1
RCE1B1 2 3     RCE1 (S. Cerevisiae) Homolog, Prenyl Protein Protease1
Prenyl Protein-Specific Endoprotease 21 2 3     RCE1 Homolog, Prenyl Protein Peptidase (S. Cerevisiae)1
RCE1 Homolog1 3     RCE1 Homolog, Prenyl Protein Peptidase2
CAAX Prenyl Protease 21 2     EC 3.4.22.-3
Farnesylated Protein-Converting Enzyme 21 2     FACE-23
Farnesylated Proteins-Converting Enzyme 22 3     hRCE13

External Ids:    HGNC: 137211   Entrez Gene: 99862   Ensembl: ENSG000001736537   OMIM: 6053855   UniProtKB: Q9Y2563   

Export aliases for RCE1 gene to outside databases

Previous GC identifers: GC11P069144 GC11P068292 GC11P066860 GC11P066386 GC11P066367 GC11P062938


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCE1 Gene:
This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family.
This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. (provided
by RefSeq, Jul 2008)

GeneCards Summary for RCE1 Gene: 
RCE1 (RCE1 homolog, prenyl protein protease (S. cerevisiae)) is a protein-coding gene. Diseases associated with RCE1 include phaeohyphomycosis, and follicular mucinosis, and among its related super-pathways are superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) and G-protein signaling Rap1B regulation pathway. GO annotations related to this gene include cysteine-type endopeptidase activity and metalloendopeptidase activity.

UniProtKB/Swiss-Prot: FACE2_HUMAN, Q9Y256
Function: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to
be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1

Gene Wiki entry for RCE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCE1 gene promoter:
         MEF-2   AP-2gamma   MEF-2A   PPAR-gamma1   AP-2beta   PPAR-gamma2   aMEF-2   AP-2alpha   NF-E2   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RCE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

RCE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCE1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066611:  view genomic region     (about GC identifiers)

Start:
66,610,306 bp from pter      End:
66,614,017 bp from pter
Size:
3,712 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FACE2_HUMAN, Q9Y256 (See protein sequence)
Recommended Name: CAAX prenyl protease 2  
Size: 329 amino acids; 35833 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q52LZ9

Explore the universe of human proteins at neXtProt for RCE1: NX_Q9Y256

Explore proteomics data for RCE1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated. Undergoes 'Lys-48'-and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its
    degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y256

  • RCE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCE1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001027450.1  NP_005124.1  

    ENSEMBL proteins: 
     ENSP00000309163   ENSP00000436600   ENSP00000436300   ENSP00000435409  

    Human Recombinant Protein Products for RCE1: 
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    OriGene Protein Over-expression Lysate for RCE1
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    Novus Biologicals RCE1 Protein
    Novus Biologicals RCE1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA19188362
    GO:0005887integral to plasma membrane TAS10085068
    GO:0016020membrane ----

    RCE1 for ontologies           About GeneDecksing



    RCE1 Antibody Products: 
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    Abcam antibodies for RCE1
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    ThermoFisher Antibodies for RCE1
    LSBio Antibodies in human, mouse, rat for RCE1 

    Assay Products for RCE1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RCE1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003675 CAAX_protease

    Graphical View of Domain Structure for InterPro Entry Q9Y256

    ProtoNet protein and cluster: Q9Y256

    1 Blocks protein domain: IPB003675 Abortive infection protein

    UniProtKB/Swiss-Prot: FACE2_HUMAN, Q9Y256
    Similarity: Belongs to the peptidase U48 family


    RCE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FACE2_HUMAN, Q9Y256
    Function: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to
    be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1
    Enzyme regulation: Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras
    GTPases

         Genatlas biochemistry entry for RCE1:
    CAAX-prenyl protein protease S cerevisiae Rce1p homolog,,ubiquitously expressed,catalyzing the the first step of
    the proteolytic processing of farnesylated proteins,including Ras

         Enzyme Number (IUBMB): EC 3.4.22.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IDA19188362
    GO:0004222metalloendopeptidase activity TAS10085068
         
    RCE1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RCE1:
     Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rce1):
     behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  muscle 

    RCE1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RCE1: Rce1tm1Kim Rce1tm2.1Kim

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCE1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCE1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCE1 

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RCE1 (see all 19):
    hsa-miR-520d-5p hsa-miR-539 hsa-miR-216b hsa-miR-149 hsa-miR-133a hsa-miR-889 hsa-miR-3649 hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmidRCE1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCE1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RCE1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
    Terpenoid backbone biosynthesis0.55
    2G-protein signaling Rap1B regulation pathway
    G-protein signaling Rap1B regulation pathway1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RCE1
        G-protein signaling Rap1B regulation pathway


    1 GeneGo (Thomson Reuters) Pathway for RCE1
        G-protein signaling Rap1B regulation pathway


    1         Kegg Pathway  (Kegg details for RCE1):
        Terpenoid backbone biosynthesis


    RCE1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCE1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for RCE1 (Q9Y2563 ENSP000003091634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3FO003033, ENSP000003100404I2D: score=1 STRING: ENSP00000310040
    UBCENSP000003448184STRING: ENSP00000344818
    ZMPSTE24ENSP000003618454STRING: ENSP00000361845
    ICMTENSP000003435524STRING: ENSP00000343552
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10085068
    GO:0071586CAAX-box protein processing IMP19188362

    RCE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RCE1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCE1 (FACE2)

    2 Novoseek inferred chemical compound relationships for RCE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tripeptide 57.8 1 12818187 (1)
    cysteine 48.5 1 12818187 (1)

    Search CenterWatch for drugs/clinical trials and news about RCE1 / FACE2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCE1 gene (2 alternative transcripts): 
    NM_001032279.1  NM_005133.2  

    Unigene Cluster for RCE1:

    RCE1 homolog, prenyl protein protease (S. cerevisiae)
    Hs.654972  [show with all ESTs]
    Unigene Representative Sequence: NM_005133
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533277 ENST00000309657(uc001ojk.1 uc001ojl.1) ENST00000524506
    ENST00000524849 ENST00000530610 ENST00000534822 ENST00000532775 ENST00000525356
    ENST00000534645
    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RCE1 (see all 19):
    hsa-miR-520d-5p hsa-miR-539 hsa-miR-216b hsa-miR-149 hsa-miR-133a hsa-miR-889 hsa-miR-3649 hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmidRCE1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCE1
    Sirion Biotech Customized lentivirus for stable overexpression of RCE1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCE1

    Additional mRNA sequence: 

    AF121951.1 BC052622.1 BC093726.1 BC093728.1 Y13835.2 

    4 DOTS entries:

    DT.441833  DT.97845282  DT.91744543  DT.100785422 

    24/222 AceView cDNA sequences (see all 222):

    AW135477 BM671083 CA487579 AL547398 BQ219278 AL537953 AI285045 BG576427 
    BE676460 AI654235 BF000305 CR597582 BX109301 AI292099 BU543442 BE856459 
    BX107454 BM928167 BF436853 BM786966 AA910288 CB850516 AK026184 AL713740 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RCE1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                          -     -                       -                                                   
    SP2:                          -     -                       -                                                   
    SP3:                                                        -                             -                     
    SP4:                                                        -                                                   
    SP5:                          -     -                                                                           


    ECgene alternative splicing isoforms for RCE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTCCCAG
    RCE1 Expression
    About this image


    See RCE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCE1

    SOURCE GeneReport for Unigene cluster: Hs.654972

    UniProtKB/Swiss-Prot: FACE2_HUMAN, Q9Y256
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for RCE1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RCE1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rce11 , 5 RCE1 homolog, prenyl protein peptidase (S. cerevisiae)1, 5 89.46(n)1
    94.83(a)1
      19 (4.07 cM)5
    196711  NM_023131.11  NP_075620.11 
     46225515 
    lizard
    (Anolis carolinensis)
    Reptilia RCE16
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343832.1(124146-132538)
    zebrafish
    (Danio rerio)
    Actinopterygii rce1a1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae) more 67.01(n)
    72.51(a)
      557720  XM_001919194.3  XP_001919229.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sras3 proteolysis and peptidolysis prenyl
    protein specific more
    41(a)   64D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea fce-26
    Protein FCE-2
    30(a)
    1 ↔ 1
    V(20425301-20431337)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RCE1(YMR274C)4 Type II CAAX prenyl protease involved in the proteolysis more   --   13(815311-814364) 855317  NP_014001.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FACE21 CAAX prenyl protease 2 45.57(n)
    35.96(a)
      818203  NM_179931.3  NP_850262.2 


    ENSEMBL Gene Tree for RCE1 (if available)
    TreeFam Gene Tree for RCE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 SNPs in RCE1 are shown (see all 87)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364074
    A breast cancer sample4--see VAR_0364072 P A mis40--------
    rs1833729391,2
    C--66611507(+) CTGACC/TATGGT 4 T syn10--------
    rs1880692901,2
    C--66611525(+) CCTGCG/TGTATT 2 -- int10--------
    rs1924843001,2
    C--66611527(+) TGCTGA/C/TATTTT 2 -- int10--------
    rs2017689381,2
    --66611528(+) GCTGTA/GTTTTT 2 -- int10--------
    rs1434518631,2
    C--66611543(+) CTGGTC/GTTTGT 2 -- int10--------
    rs1512258861,2
    C--66611552(+) GTTATC/TAGCCT 2 -- int10--------
    rs2021979981,2
    C--66611714(+) TCTGGG/AAAAAG 2 -- int11Minor allele frequency- A:0.00EU 593
    rs2002396401,2
    C--66611750(+) TCTTGC/TCCTCA 2 -- int11Minor allele frequency- T:0.00EU 1283
    rs1837986781,2
    C--66611873(+) ACAGGC/TAGTCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for RCE1 (66610306 - 66614017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RCE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv364CNV Insertion18451855
    nsv508638CNV Loss20534489
    nsv468602CNV Loss19166990
    nsv897790CNV Loss21882294
    nsv897795CNV Loss21882294
    nsv897794CNV Loss21882294
    nsv897789CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605385    OMIM disorders: --

    6 diseases for RCE1:    About MalaCards
    phaeohyphomycosis    follicular mucinosis    mandibuloacral dysplasia    legionnaires' disease
    impetigo    progeria

    3 diseases from the University of Copenhagen DISEASES database for RCE1:
    Phaeohyphomycosis     Follicular mucinosis     Progeria

    RCE1 for disorders           About GeneDecksing


    Export disorders for RCE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCE1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with RCE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a mammalian prenyl protein-specific protease. (PubMed id 10085068)1, 2, 3, 9 Otto J.C.... Casey P.J. (1999)
    2. Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. (PubMed id 10373325)1, 2, 3, 9 Freije J.M.P....Lopez-Otin C. (1999)
    3. Human ras-converting enzyme (hRCE1) endoproteolytic activity on K- ras-derived peptides. (PubMed id 11038283)1, 2, 9 Hollander I.... Mallon R. (2000)
    4. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. (PubMed id 19188362)1, 2, 9 Burrows J.F....Johnston J.A. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides. (PubMed id 12818187)1, 9 Hollander I.J....Mallon R. (2003)
    7. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9986 HGNC: 13721 AceView: RCE1andFLJ22531 Ensembl:ENSG00000173653 euGenes: HUgn9986
    ECgene: RCE1 Kegg: 9986 H-InvDB: RCE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCE1 gene:
    Search GeneIP for patents involving RCE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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