External Ids for RCCD1 Gene
Previous GeneCards Identifiers for RCCD1 Gene
GeneCards Summary for RCCD1 Gene
RCCD1 (RCC1 Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is HERC2.
UniProtKB/Swiss-Prot for RCCD1 Gene
Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated Lys-36 (H3K36me2/me3) of histone H3 (PubMed:24981860). Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245).