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Aliases for RCCD1 Gene

Aliases for RCCD1 Gene

  • RCC1 Domain Containing 1 2 3 5

External Ids for RCCD1 Gene

Previous GeneCards Identifiers for RCCD1 Gene

  • GC15P089301
  • GC15P091498
  • GC15P067609

Summaries for RCCD1 Gene

GeneCards Summary for RCCD1 Gene

RCCD1 (RCC1 Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is HERC5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCCD1 Gene

Genomics for RCCD1 Gene

Regulatory Elements for RCCD1 Gene

Enhancers for RCCD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RCCD1 on UCSC Golden Path with GeneCards custom track

Promoters for RCCD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RCCD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RCCD1 Gene

Chromosome:
15
Start:
90,954,695 bp from pter
End:
90,963,543 bp from pter
Size:
8,849 bases
Orientation:
Plus strand

Genomic View for RCCD1 Gene

Genes around RCCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCCD1 Gene

Proteins for RCCD1 Gene

  • Protein details for RCCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NED2-RCCD1_HUMAN
    Recommended name:
    RCC1 domain-containing protein 1
    Protein Accession:
    A6NED2
    Secondary Accessions:
    • B2RTP9
    • Q29RX6

    Protein attributes for RCCD1 Gene

    Size:
    376 amino acids
    Molecular mass:
    40079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RCCD1 Gene

Proteomics data for RCCD1 Gene at MOPED

Post-translational modifications for RCCD1 Gene

  • Ubiquitination at Lys 271, Lys 352, Lys 373, and Lys 375
  • Modification sites at PhosphoSitePlus

Other Protein References for RCCD1 Gene

No data available for DME Specific Peptides for RCCD1 Gene

Domains & Families for RCCD1 Gene

Protein Domains for RCCD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RCCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NED2

UniProtKB/Swiss-Prot:

RCCD1_HUMAN :
  • Contains 4 RCC1 repeats.
Similarity:
  • Contains 4 RCC1 repeats.
genes like me logo Genes that share domains with RCCD1: view

No data available for Gene Families for RCCD1 Gene

Function for RCCD1 Gene

genes like me logo Genes that share phenotypes with RCCD1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCCD1 Gene

Localization for RCCD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCCD1 Gene COMPARTMENTS Subcellular localization image for RCCD1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for RCCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RCCD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RCCD1 Gene

Pathways & Interactions for RCCD1 Gene

SuperPathways for RCCD1 Gene

No Data Available

Interacting Proteins for RCCD1 Gene

Gene Ontology (GO) - Biological Process for RCCD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RCCD1 Gene

Drugs & Compounds for RCCD1 Gene

No Compound Related Data Available

Transcripts for RCCD1 Gene

Unigene Clusters for RCCD1 Gene

RCC1 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCCD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: -
SP2: -
SP3:
SP4: - -
SP5: -
SP6:

Relevant External Links for RCCD1 Gene

GeneLoc Exon Structure for
RCCD1
ECgene alternative splicing isoforms for
RCCD1

Expression for RCCD1 Gene

mRNA expression in normal human tissues for RCCD1 Gene

Protein differential expression in normal tissues from HIPED for RCCD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.3), Gallbladder (9.8), Pancreas (8.3), and Prostate (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCCD1 Gene



SOURCE GeneReport for Unigene cluster for RCCD1 Gene Hs.655895

genes like me logo Genes that share expression patterns with RCCD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RCCD1 Gene

Orthologs for RCCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCCD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RCCD1 35
  • 84.45 (n)
  • 80.43 (a)
RCCD1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCCD1 35
  • 85.65 (n)
  • 82.19 (a)
RCCD1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rccd1 35
  • 77.27 (n)
  • 74.87 (a)
Rccd1 16
Rccd1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RCCD1 35
  • 99.73 (n)
  • 100 (a)
RCCD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rccd1 35
  • 79.3 (n)
  • 75.81 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RCCD1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves RCCD1 35
  • 65.57 (n)
  • 61.84 (a)
RCCD1 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCCD1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rccd1 35
  • 60.17 (n)
  • 55.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17685 35
zebrafish
(Danio rerio)
Actinopterygii rccd1 35
  • 56.75 (n)
  • 51.72 (a)
rccd1 36
  • 39 (a)
OneToMany
rccd1 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6678 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K11D2.1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for RCCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCCD1 Gene

ENSEMBL:
Gene Tree for RCCD1 (if available)
TreeFam:
Gene Tree for RCCD1 (if available)

Paralogs for RCCD1 Gene

Paralogs for RCCD1 Gene

(1) SIMAP similar genes for RCCD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RCCD1: view

Variants for RCCD1 Gene

Sequence variations from dbSNP and Humsavar for RCCD1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs4932380 - 90,956,756(+) CGGGG(C/G/T)CCTGG reference, missense
rs13630 -- 90,961,979(-) TTCAT(G/T)GTTTT utr-variant-3-prime
rs14484 -- 90,962,217(+) GGAAT(C/G)CTGTG utr-variant-3-prime
rs5814447 -- 90,958,628(+) GTCTC(-/A)AAAAA intron-variant
rs5814449 -- 90,958,954(+) AAAAC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCCD1 Gene

Variant ID Type Subtype PubMed ID
nsv833089 CNV Loss 17160897
nsv515661 CNV Loss 19592680
nsv833090 CNV Loss 17160897

Variation tolerance for RCCD1 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 69.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RCCD1 Gene

Disorders for RCCD1 Gene

Relevant External Links for RCCD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCCD1

No disorders were found for RCCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCCD1 Gene

Publications for RCCD1 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation. (PMID: 24981860) Marcon E. … Greenblatt J. (Cell Rep 2014) 3
  5. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. (PMID: 25038754) Cai Q. … Zheng W. (Nat. Genet. 2014) 3

Products for RCCD1 Gene

Sources for RCCD1 Gene

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