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Aliases for RCC2 Gene

Aliases for RCC2 Gene

  • Regulator Of Chromosome Condensation 2 2 3 5
  • Telophase Disk Protein Of 60 KDa 3 4
  • RCC1-Like Protein TD-60 3 4
  • Protein RCC2 3
  • KIAA1470 4
  • TD-60 3
  • TD60 4

External Ids for RCC2 Gene

Previous GeneCards Identifiers for RCC2 Gene

  • GC01M017479
  • GC01M017605
  • GC01M017733
  • GC01M015979

Summaries for RCC2 Gene

GeneCards Summary for RCC2 Gene

RCC2 (Regulator Of Chromosome Condensation 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Cytoskeletal Signaling. GO annotations related to this gene include poly(A) RNA binding and protein domain specific binding. An important paralog of this gene is HERC2.

UniProtKB/Swiss-Prot for RCC2 Gene

  • Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Wiki entry for RCC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCC2 Gene

Genomics for RCC2 Gene

Regulatory Elements for RCC2 Gene

Enhancers for RCC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RCC2 on UCSC Golden Path with GeneCards custom track

Promoters for RCC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RCC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RCC2 Gene

Chromosome:
1
Start:
17,406,755 bp from pter
End:
17,439,754 bp from pter
Size:
33,000 bases
Orientation:
Minus strand

Genomic View for RCC2 Gene

Genes around RCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCC2 Gene

Proteins for RCC2 Gene

  • Protein details for RCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P258-RCC2_HUMAN
    Recommended name:
    Protein RCC2
    Protein Accession:
    Q9P258
    Secondary Accessions:
    • Q8IVL9
    • Q9BSN6
    • Q9NPV8

    Protein attributes for RCC2 Gene

    Size:
    522 amino acids
    Molecular mass:
    56085 Da
    Quaternary structure:
    • Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules.
    SequenceCaution:
    • Sequence=BAA95994.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB94882.1; Type=Frameshift; Positions=477; Evidence={ECO:0000305};

neXtProt entry for RCC2 Gene

Post-translational modifications for RCC2 Gene

  • Ubiquitination at Lys 92, Lys 320, Lys 349, and Lys 377
  • Modification sites at PhosphoSitePlus

Other Protein References for RCC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCC2 Gene

Domains & Families for RCC2 Gene

Protein Domains for RCC2 Gene

Suggested Antigen Peptide Sequences for RCC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P258

UniProtKB/Swiss-Prot:

RCC2_HUMAN :
  • Contains 7 RCC1 repeats.
Similarity:
  • Contains 7 RCC1 repeats.
genes like me logo Genes that share domains with RCC2: view

No data available for Gene Families for RCC2 Gene

Function for RCC2 Gene

Molecular function for RCC2 Gene

UniProtKB/Swiss-Prot Function:
Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Ontology (GO) - Molecular Function for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22282019
GO:0008017 microtubule binding IMP 12919680
GO:0019901 protein kinase binding IPI 25074804
GO:0019904 protein domain specific binding IPI 25074804
GO:0031267 small GTPase binding IPI 25074804
genes like me logo Genes that share ontologies with RCC2: view
genes like me logo Genes that share phenotypes with RCC2: view

Animal Models for RCC2 Gene

MGI Knock Outs for RCC2:
  • Rcc2 tm1b(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for RCC2 Gene

miRTarBase miRNAs that target RCC2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCC2 Gene

Localization for RCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCC2 Gene

Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCC2 Gene COMPARTMENTS Subcellular localization image for RCC2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
endosome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RCC2: view

Pathways & Interactions for RCC2 Gene

genes like me logo Genes that share pathways with RCC2: view

Pathways by source for RCC2 Gene

2 Cell Signaling Technology pathways for RCC2 Gene

Gene Ontology (GO) - Biological Process for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007229 integrin-mediated signaling pathway IDA 19738201
GO:0010762 regulation of fibroblast migration IEA --
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP 12919680
genes like me logo Genes that share ontologies with RCC2: view

No data available for SIGNOR curated interactions for RCC2 Gene

Drugs & Compounds for RCC2 Gene

(3) Drugs for RCC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RCC2: view

Transcripts for RCC2 Gene

Unigene Clusters for RCC2 Gene

Regulator of chromosome condensation 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RCC2 Gene

GeneLoc Exon Structure for
RCC2
ECgene alternative splicing isoforms for
RCC2

Expression for RCC2 Gene

mRNA expression in normal human tissues for RCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RCC2 Gene

This gene is overexpressed in Lymph node (14.6), Peripheral blood mononuclear cells (9.4), Amniocyte (8.5), and Fetal ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCC2 Gene



Protein tissue co-expression partners for RCC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RCC2 Gene:

RCC2

SOURCE GeneReport for Unigene cluster for RCC2 Gene:

Hs.380857
genes like me logo Genes that share expression patterns with RCC2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RCC2 Gene

Orthologs for RCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RCC2 34
  • 90.77 (n)
  • 97.88 (a)
RCC2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCC2 34
  • 91.88 (n)
  • 98.83 (a)
RCC2 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcc2 34
  • 87.69 (n)
  • 96.35 (a)
Rcc2 16
Rcc2 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RCC2 34
  • 99.3 (n)
  • 99.77 (a)
RCC2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rcc2 34
  • 86.96 (n)
  • 96.96 (a)
oppossum
(Monodelphis domestica)
Mammalia RCC2 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCC2 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RCC2 34
  • 83.61 (n)
  • 94.15 (a)
RCC2 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCC2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494942 34
  • 78.11 (n)
  • 88.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7388 34
zebrafish
(Danio rerio)
Actinopterygii rcc2 34
  • 72.37 (n)
  • 82.89 (a)
rcc2 35
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8430 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002151 34
  • 54.44 (n)
  • 48.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9135 34
  • 52.74 (n)
  • 46.41 (a)
CG9135 35
  • 47 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G19880 34
  • 48.52 (n)
  • 39.9 (a)
rice
(Oryza sativa)
Liliopsida Os04g0662800 34
  • 47.95 (n)
  • 42.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2242 35
  • 50 (a)
OneToOne
Species where no ortholog for RCC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCC2 Gene

ENSEMBL:
Gene Tree for RCC2 (if available)
TreeFam:
Gene Tree for RCC2 (if available)

Paralogs for RCC2 Gene

Paralogs for RCC2 Gene

genes like me logo Genes that share paralogs with RCC2: view

Variants for RCC2 Gene

Sequence variations from dbSNP and Humsavar for RCC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7191 -- 17,407,068(+) CCCAT(G/T)TTTCA utr-variant-3-prime
rs730153 -- 17,423,008(+) TGCCC(A/G)CTGGA intron-variant
rs750636 -- 17,408,770(-) TTCCT(C/T)TCCTG utr-variant-3-prime
rs942457 -- 17,413,090(-) AGAAT(C/T)CGGAG reference, synonymous-codon
rs942458 -- 17,412,817(-) AAATA(A/C)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCC2 Gene

Variant ID Type Subtype PubMed ID
dgv53n106 CNV deletion 24896259
nsv1075665 CNV deletion 25765185
nsv821932 CNV gain 20364138
nsv945802 CNV duplication 23825009

Variation tolerance for RCC2 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCC2 Gene

Disorders for RCC2 Gene

Relevant External Links for RCC2

Genetic Association Database (GAD)
RCC2
Human Genome Epidemiology (HuGE) Navigator
RCC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCC2

No disorders were found for RCC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCC2 Gene

Publications for RCC2 Gene

  1. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. (PMID: 12919680) Mollinari C. … Margolis R.L. (Dev. Cell 2003) 2 3 4 22 65
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 65
  3. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PMID: 18849993) Stacey S.N. … Stefansson K. (Nat. Genet. 2008) 3 46 65
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for RCC2 Gene

Sources for RCC2 Gene

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