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Aliases for RCC2 Gene

Aliases for RCC2 Gene

  • Regulator Of Chromosome Condensation 2 2 3 5
  • Telophase Disk Protein Of 60 KDa 3 4
  • RCC1-Like Protein TD-60 3 4
  • Protein RCC2 3
  • KIAA1470 4
  • TD-60 3
  • TD60 4

External Ids for RCC2 Gene

Previous GeneCards Identifiers for RCC2 Gene

  • GC01M017479
  • GC01M017605
  • GC01M017733
  • GC01M015979

Summaries for RCC2 Gene

Entrez Gene Summary for RCC2 Gene

  • The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]

GeneCards Summary for RCC2 Gene

RCC2 (Regulator Of Chromosome Condensation 2) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and protein domain specific binding. An important paralog of this gene is RCBTB2.

UniProtKB/Swiss-Prot for RCC2 Gene

  • Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Wiki entry for RCC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCC2 Gene

Genomics for RCC2 Gene

Regulatory Elements for RCC2 Gene

Enhancers for RCC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G016902 1.9 FANTOM5 ENCODE dbSUPER 18 +534.7 534705 4.9 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC ZBTB17 MFAP2 RPL22P3 ENSG00000224621 RCC2 EIF1AXP1 LOC105376805 ENSG00000235241 FAM131C PADI2
GH01G016498 1.6 FANTOM5 ENCODE dbSUPER 9.7 +940.7 940684 2.0 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF121 GTF3C2 GLIS2 ZNF143 ENSG00000237938 NECAP2 CROCCP3 SPATA21 SPEN ENSG00000224621 RPS16P1 DDI2 RCC2 FAM131C
GH01G016894 1.4 ENCODE dbSUPER 10 +543.6 543569 2.8 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF766 MFAP2 ZBTB17 RCC2 ENSG00000235241 LOC105376805 RNU1-2 ENSG00000272426
GH01G016729 1.4 ENCODE dbSUPER 9.7 +712.2 712214 0.2 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ENSG00000237938 SPEN RPS16P1 ZBTB17 RPL22P3 ENSG00000224621 LINC01772 MFAP2 CROCCP2 NBPF1
GH01G016544 1.4 Ensembl ENCODE 9.7 +894.4 894440 2.0 HDGF MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF2 KLF13 SP3 SPEN ENSG00000237938 LINC01772 ENSG00000224621 RPS16P1 DDI2 FLJ37453 RCC2 ENSG00000261135 ARHGEF19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RCC2 on UCSC Golden Path with GeneCards custom track

Promoters for RCC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002234 1054 3001 HDGF FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF766 ZNF207 FOS

Genomic Location for RCC2 Gene

17,406,755 bp from pter
17,439,754 bp from pter
33,000 bases
Minus strand

Genomic View for RCC2 Gene

Genes around RCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCC2 Gene

Proteins for RCC2 Gene

  • Protein details for RCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RCC2
    Protein Accession:
    Secondary Accessions:
    • Q8IVL9
    • Q9BSN6
    • Q9NPV8

    Protein attributes for RCC2 Gene

    522 amino acids
    Molecular mass:
    56085 Da
    Quaternary structure:
    • Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules.
    • Sequence=BAA95994.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB94882.1; Type=Frameshift; Positions=477; Evidence={ECO:0000305};

neXtProt entry for RCC2 Gene

Post-translational modifications for RCC2 Gene

  • Ubiquitination at isoforms=92, Lys320, isoforms=349, and Lys377
  • Modification sites at PhosphoSitePlus

Other Protein References for RCC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCC2 Gene

Domains & Families for RCC2 Gene

Protein Domains for RCC2 Gene

Suggested Antigen Peptide Sequences for RCC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RCC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RCC2 Gene

Function for RCC2 Gene

Molecular function for RCC2 Gene

UniProtKB/Swiss-Prot Function:
Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Ontology (GO) - Molecular Function for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 22282019
GO:0008017 microtubule binding IMP 12919680
GO:0019901 protein kinase binding IPI 25074804
GO:0019904 protein domain specific binding IPI 25074804
genes like me logo Genes that share ontologies with RCC2: view
genes like me logo Genes that share phenotypes with RCC2: view

Animal Models for RCC2 Gene

MGI Knock Outs for RCC2:
  • Rcc2 tm1b(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for RCC2 Gene

miRTarBase miRNAs that target RCC2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCC2 Gene

Localization for RCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCC2 Gene

Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
endosome 2

Gene Ontology (GO) - Cellular Components for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with RCC2: view

Pathways & Interactions for RCC2 Gene

genes like me logo Genes that share pathways with RCC2: view

Pathways by source for RCC2 Gene

2 Cell Signaling Technology pathways for RCC2 Gene

Gene Ontology (GO) - Biological Process for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007229 integrin-mediated signaling pathway IDA 19738201
GO:0010762 regulation of fibroblast migration IEA --
genes like me logo Genes that share ontologies with RCC2: view

No data available for SIGNOR curated interactions for RCC2 Gene

Drugs & Compounds for RCC2 Gene

(3) Drugs for RCC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RCC2: view

Transcripts for RCC2 Gene

Unigene Clusters for RCC2 Gene

Regulator of chromosome condensation 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15
SP2: - -

Relevant External Links for RCC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RCC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RCC2 Gene

This gene is overexpressed in Lymph node (14.6), Peripheral blood mononuclear cells (9.4), Amniocyte (8.5), and Fetal ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCC2 Gene

Protein tissue co-expression partners for RCC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RCC2 Gene:


SOURCE GeneReport for Unigene cluster for RCC2 Gene:


Evidence on tissue expression from TISSUES for RCC2 Gene

  • Nervous system(4.5)
  • Blood(4.3)
  • Muscle(4.1)
  • Skin(3.3)
  • Intestine(2.4)
  • Stomach(2.4)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with RCC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCC2 Gene

Orthologs for RCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RCC2 34 35
  • 99.3 (n)
(Ornithorhynchus anatinus)
Mammalia RCC2 35
  • 97 (a)
(Monodelphis domestica)
Mammalia RCC2 35
  • 96 (a)
(Canis familiaris)
Mammalia RCC2 34 35
  • 91.88 (n)
(Bos Taurus)
Mammalia RCC2 34 35
  • 90.77 (n)
(Mus musculus)
Mammalia Rcc2 34 16 35
  • 87.69 (n)
(Rattus norvegicus)
Mammalia Rcc2 34
  • 86.96 (n)
(Gallus gallus)
Aves RCC2 34 35
  • 83.61 (n)
(Anolis carolinensis)
Reptilia RCC2 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494942 34
  • 78.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7388 34
(Danio rerio)
Actinopterygii rcc2 34 35
  • 72.37 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8430 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002151 34
  • 54.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9135 34 35
  • 52.74 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G19880 34
  • 48.52 (n)
(Oryza sativa)
Liliopsida Os04g0662800 34
  • 47.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2242 35
  • 50 (a)
Species where no ortholog for RCC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCC2 Gene

Gene Tree for RCC2 (if available)
Gene Tree for RCC2 (if available)

Paralogs for RCC2 Gene

Variants for RCC2 Gene

Sequence variations from dbSNP and Humsavar for RCC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs864622010 Uncertain significance 17,420,791(-) GGCCT(C/G)TGGGG reference, missense
rs1000120645 -- 17,425,498(+) CAGCT(C/G)GTGAC intron-variant
rs1000238836 -- 17,410,356(+) AAGAG(A/G)TGACA intron-variant
rs1000279124 -- 17,436,705(+) GCTGT(A/G)CAGCT intron-variant
rs1000365810 -- 17,416,227(+) GGTGA(C/G)GGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCC2 Gene

Variant ID Type Subtype PubMed ID
dgv53n106 CNV deletion 24896259
nsv1075665 CNV deletion 25765185
nsv821932 CNV gain 20364138
nsv945802 CNV duplication 23825009

Variation tolerance for RCC2 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCC2 Gene

Disorders for RCC2 Gene

Relevant External Links for RCC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RCC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCC2 Gene

Publications for RCC2 Gene

  1. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. (PMID: 12919680) Mollinari C. … Margolis R.L. (Dev. Cell 2003) 2 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PMID: 18849993) Stacey S.N. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RCC2 Gene

Sources for RCC2 Gene

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