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Aliases for RCC2 Gene

Aliases for RCC2 Gene

  • Regulator Of Chromosome Condensation 2 2 3
  • Telophase Disk Protein Of 60 KDa 3 4
  • RCC1-Like Protein TD-60 3 4
  • Protein RCC2 3
  • KIAA1470 4
  • TD-60 3
  • TD60 4

External Ids for RCC2 Gene

Summaries for RCC2 Gene

GeneCards Summary for RCC2 Gene

RCC2 (Regulator Of Chromosome Condensation 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. An important paralog of this gene is RCBTB2.

UniProtKB/Swiss-Prot for RCC2 Gene

  • Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Wiki entry for RCC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCC2 Gene

Genomics for RCC2 Gene

Genomic Location for RCC2 Gene

Start:
17,406,755 bp from pter
End:
17,439,754 bp from pter
Size:
33,000 bases
Orientation:
Minus strand

Genomic View for RCC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCC2 Gene

Regulatory Elements for RCC2 Gene

Proteins for RCC2 Gene

  • Protein details for RCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P258-RCC2_HUMAN
    Recommended name:
    Protein RCC2
    Protein Accession:
    Q9P258
    Secondary Accessions:
    • Q8IVL9
    • Q9BSN6
    • Q9NPV8

    Protein attributes for RCC2 Gene

    Size:
    522 amino acids
    Molecular mass:
    56085 Da
    Quaternary structure:
    • Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules.
    SequenceCaution:
    • Sequence=BAA95994.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB94882.1; Type=Frameshift; Positions=477; Evidence={ECO:0000305};

neXtProt entry for RCC2 Gene

Proteomics data for RCC2 Gene at MOPED

Post-translational modifications for RCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys92, Lys293, Lys320, Lys349, and Lys377

Other Protein References for RCC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RCC2 Gene

Domains for RCC2 Gene

Protein Domains for RCC2 Gene

UniProtKB/Swiss-Prot:

RCC2_HUMAN
Similarity:
  • Contains 7 RCC1 repeats.:
    • Q9P258
genes like me logo Genes that share domains with RCC2: view

No data available for Gene Families for RCC2 Gene

Function for RCC2 Gene

Molecular function for RCC2 Gene

UniProtKB/Swiss-Prot Function: Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Ontology (GO) - Molecular Function for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22282019
GO:0008017 microtubule binding IMP 12919680
GO:0019901 protein kinase binding IPI 25074804
GO:0019904 protein domain specific binding IPI 25074804
GO:0031267 small GTPase binding IPI 25074804
genes like me logo Genes that share ontologies with RCC2: view

Phenotypes for RCC2 Gene

genes like me logo Genes that share phenotypes with RCC2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RCC2 Gene

Localization for RCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCC2 Gene

Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCC2 Gene COMPARTMENTS Subcellular localization image for RCC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
GO:0016020 colocalizes_with membrane IDA 25074804
genes like me logo Genes that share ontologies with RCC2: view

Pathways for RCC2 Gene

genes like me logo Genes that share pathways with RCC2: view

Pathways by source for RCC2 Gene

Gene Ontology (GO) - Biological Process for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007032 endosome organization IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007229 integrin-mediated signaling pathway IDA 19738201
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RCC2: view

Compounds for RCC2 Gene

(3) HMDB Compounds for RCC2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RCC2: view

Transcripts for RCC2 Gene

Unigene Clusters for RCC2 Gene

Regulator of chromosome condensation 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RCC2 Gene

GeneLoc Exon Structure for
RCC2
ECgene alternative splicing isoforms for
RCC2

Expression for RCC2 Gene

mRNA expression in normal human tissues for RCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCC2 Gene

SOURCE GeneReport for Unigene cluster for RCC2 Gene Hs.380857

genes like me logo Genes that share expressions with RCC2: view

Orthologs for RCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCC2 36
  • 99.3 (n)
  • 99.77 (a)
RCC2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RCC2 36
  • 90.77 (n)
  • 97.88 (a)
RCC2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCC2 36
  • 91.88 (n)
  • 98.83 (a)
RCC2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcc2 36
  • 87.69 (n)
  • 96.35 (a)
Rcc2 16
Rcc2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RCC2 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCC2 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rcc2 36
  • 86.96 (n)
  • 96.96 (a)
chicken
(Gallus gallus)
Aves RCC2 36
  • 83.61 (n)
  • 94.15 (a)
RCC2 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCC2 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7388 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494942 36
  • 78.11 (n)
  • 88.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8430 36
zebrafish
(Danio rerio)
Actinopterygii rcc2 36
  • 72.37 (n)
  • 82.89 (a)
rcc2 37
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002151 36
  • 54.44 (n)
  • 48.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9135 36
  • 52.74 (n)
  • 46.41 (a)
CG9135 37
  • 47 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G19880 36
  • 48.52 (n)
  • 39.9 (a)
rice
(Oryza sativa)
Liliopsida Os04g0662800 36
  • 47.95 (n)
  • 42.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2242 37
  • 50 (a)
OneToOne
Species with no ortholog for RCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCC2 Gene

ENSEMBL:
Gene Tree for RCC2 (if available)
TreeFam:
Gene Tree for RCC2 (if available)

Paralogs for RCC2 Gene

Paralogs for RCC2 Gene

genes like me logo Genes that share paralogs with RCC2: view

Variants for RCC2 Gene

Sequence variations from dbSNP and Humsavar for RCC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs750636 -- 17,408,770(-) TTCCT(C/T)TCCTG utr-variant-3-prime
rs942457 -- 17,413,090(-) AGAAT(C/T)CGGAG reference, synonymous-codon
rs942458 -- 17,412,817(-) AAATA(A/C)ACAAG intron-variant
rs1052580 -- 17,407,975(+) TTGAC(A/G)AGGAC utr-variant-3-prime
rs1052791 -- 17,406,879(+) CTCCT(C/T)TTTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RCC2 Gene

Variant ID Type Subtype PubMed ID
nsv821932 CNV Gain 20364138

Relevant External Links for RCC2 Gene

HapMap Linkage Disequilibrium report
RCC2

Disorders for RCC2 Gene

Relevant External Links for RCC2

Genetic Association Database (GAD)
RCC2
Human Genome Epidemiology (HuGE) Navigator
RCC2
genes like me logo Genes that share disorders with RCC2: view

No data available for UniProtKB/Swiss-Prot for RCC2 Gene

Publications for RCC2 Gene

  1. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. (PMID: 12919680) Mollinari C. … Margolis R.L. (Dev. Cell 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis. (PMID: 1939370) Andreassen P.R. … Margolis R.L. (J. Cell Sci. 1991) 3 4
  5. Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery. (PMID: 7559776) Martineau S.N. … Margolis R.L. (J. Cell Biol. 1995) 3 4

Products for RCC2 Gene

Sources for RCC2 Gene

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