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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCC2 Gene

protein-coding   GIFtS: 58
GCID: GC01M017733

Regulator Of Chromosome Condensation 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of Chromosome Condensation 21 2     Protein RCC22
Telophase Disk Protein Of 60 KDa2 3     KIAA14703
RCC1-Like Protein TD-602 3     TD603
TD-602     

External Ids:    HGNC: 302971   Entrez Gene: 559202   Ensembl: ENSG000001790517   OMIM: 6095875   UniProtKB: Q9P2583   

Export aliases for RCC2 gene to outside databases

Previous GC identifers: GC01M017479 GC01M017605 GC01M015979


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RCC2 Gene: 
RCC2 (regulator of chromosome condensation 2) is a protein-coding gene. Diseases associated with RCC2 include basal cell carcinoma, and melanoma, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase. An important paralog of this gene is SERGEF.

UniProtKB/Swiss-Prot: RCC2_HUMAN, Q9P258
Function: Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor
for the small GTPase RAC1

Gene Wiki entry for RCC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCC2 gene promoter:
         CBF-B   AML1a   Chx10   CP1A   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RCC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

RCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M017733:  view genomic region     (about GC identifiers)

Start:
17,733,251 bp from pter      End:
17,766,220 bp from pter
Size:
32,970 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RCC2_HUMAN, Q9P258 (See protein sequence)
Recommended Name: Protein RCC2  
Size: 522 amino acids; 56085 Da
Subunit: Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules
Subcellular location: Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears
in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase.
Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire
equatorial diameter from cortex to cortex
Sequence caution: Sequence=BAA95994.1; Type=Erroneous initiation; Sequence=CAB94882.1; Type=Frameshift;
Positions=477;
Secondary accessions: Q8IVL9 Q9BSN6 Q9NPV8

Explore the universe of human proteins at neXtProt for RCC2: NX_Q9P258

Explore proteomics data for RCC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P258

  • RCC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCC2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129676.1  NP_061185.1  

    ENSEMBL proteins: 
     ENSP00000364585   ENSP00000364582  
    Reactome Protein details: Q9P258
    Human Recombinant Protein Products for RCC2: 
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    Browse OriGene Protein Over-expression Lysates
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RCC2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0005730nucleolus IEA--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--

    RCC2 for ontologies           About GeneDecksing



    RCC2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for RCC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry Q9P258

    ProtoNet protein and cluster: Q9P258

    1 Blocks protein domain: IPB000408 Regulator of chromosome condensation

    UniProtKB/Swiss-Prot: RCC2_HUMAN, Q9P258
    Similarity: Contains 7 RCC1 repeats


    RCC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCC2_HUMAN, Q9P258
    Function: Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor
    for the small GTPase RAC1

    Phenotypes:
         2 GenomeRNAi human phenotypes for RCC2:

     Decreased circadian period len  Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCC2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCC2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCC2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCC2
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate RCC2 (see all 48):
    hsa-miR-29a hsa-miR-4275 hsa-miR-502-3p hsa-miR-548m hsa-miR-124 hsa-miR-3622b-3p hsa-miR-508-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidRCC2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCC2
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                         Customized lentivirus expression plasmids for stable overexpression of RCC2 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RCC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4DNA Damage
    Cell Cycle / Checkpoint Control0.32
    5Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RCC2
        Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    5/9        Reactome Pathways for RCC2 (see all 9)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    RCC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/99 Interacting proteins for RCC2 (Q9P2583 ENSP000003645824) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKBQ96GD43, ENSP000003139504I2D: score=1 STRING: ENSP00000313950
    CDCA8Q53HL23, ENSP000003161214I2D: score=1 STRING: ENSP00000316121
    RAC1P630003, ENSP000003484614I2D: score=1 STRING: ENSP00000348461
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0051301cell division IEA--

    RCC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCC2

    3 HMDB Compounds for RCC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RCC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCC2 gene (2 alternative transcripts): 
    NM_001136204.2  NM_018715.3  

    Unigene Cluster for RCC2:

    Regulator of chromosome condensation 2
    Hs.380857  [show with all ESTs]
    Unigene Representative Sequence: NM_018715
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375436(uc001bal.3 uc001bam.3) ENST00000474892 ENST00000375433

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCC2
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate RCC2 (see all 48):
    hsa-miR-29a hsa-miR-4275 hsa-miR-502-3p hsa-miR-548m hsa-miR-124 hsa-miR-3622b-3p hsa-miR-508-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidRCC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RCC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCC2
    Clone
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    OriGene clones in human, mouse for RCC2 (see all 9)
    OriGene ORF clones in mouse, rat for RCC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RCC2 (NM_000400)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCC2
    Sirion Biotech Customized lentivirus for stable overexpression of RCC2 
                         Customized lentivirus expression plasmids for stable overexpression of RCC2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RCC2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCC2

    Additional mRNA sequence: 

    AB040903.1 AJ421269.1 AK026005.1 AK126021.1 AL359612.1 BC004933.1 BC042141.1 BC053908.1 
    BC142946.1 

    20 DOTS entries:

    DT.100805235  DT.456264  DT.101987276  DT.101977209  DT.95119529  DT.97813661  DT.91886477  DT.91758883 
    DT.91758891  DT.97867745  DT.100848078  DT.121303350  DT.95249861  DT.102833822  DT.121412910  DT.449107 
    DT.87003895  DT.92414389  DT.97796686  DT.97866273 

    24/487 AceView cDNA sequences (see all 487):

    BM848762 CR617891 BM806802 AL359612 AW169809 AI570430 BM826003 AW955566 
    CR619013 BM854106 N35291 BM721813 BQ269465 BM552492 BX109581 BQ217780 
    AI439797 BM818697 AW193051 BQ215064 BU740014 BM820570 BU521471 BU160556 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RCC2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15
    SP1:                                                                                                                                    
    SP2:                                                                                -     -                                             
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for RCC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCC2 expression in normal human tissues (normalized intensities)      RCC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTCCTAA
    RCC2 Expression
    About this image


    RCC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

     -- (Gastrointestinal Tract)
             visceral organ/oral region/gland   

    See RCC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCC2

    SOURCE GeneReport for Unigene cluster: Hs.380857
        SABiosciences Custom PCR Arrays for RCC2
    Primer
    Products:
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RCC2 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcc21 , 5 regulator of chromosome condensation 21, 5 87.69(n)1
    96.35(a)1
      4 (72.15 cM)5
    1089111  NM_173867.51  NP_776292.11 
     1407005415 
    chicken
    (Gallus gallus)
    Aves RCC21 regulator of chromosome condensation 2 83.61(n)
    94.15(a)
      419361  XM_417522.2  XP_417522.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    RCC26
    regulator of chromosome condensation 2
    86(a)
    81(a)
    possible ortholog
    1 ↔ 1
    AAWZ02038943(3763-7031)
    GL344443.1(21-32014)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73882 Xenopus laevis transcribed sequence with moderate similarity more 76.72(n)    BX843204.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD759489.12   -- 79.31(n)    CD759489.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91351 CG9135 52.56(n)
    46.53(a)
      33850  NM_135141.2  NP_608985.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRM16
    Nucleotide exchange factor for Gsp1p, localizes to...
    16(a)
    1 → many
    VII(321782-323230)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G198801 regulator of chromosome condensation (RCC1) family more 48.67(n)
    40.87(a)
      838576  NM_101843.3  NP_173417.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g06628001 hypothetical protein 47.95(n)
    41.63(a)
      4337298  NM_001060694.1  NP_001054159.1 


    ENSEMBL Gene Tree for RCC2 (if available)
    TreeFam Gene Tree for RCC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCC2 gene
    SERGEF2  RCBTB22  IBTK2  WBSCR162  RCC12  RPGR2  RCBTB12  

    RCC2 for paralogs           About GeneDecksing


    5/10 Pseudogenes.org Pseudogenes for RCC2 (see all 10)
    PGOHUM00000242758 PGOHUM00000244513 PGOHUM00000237753 PGOHUM00000238101 PGOHUM00000245650


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/843 SNPs in RCC2 are shown (see all 843)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458367121,2
    C--16013228(+) GGGACG/TCTCCA 1 -- us2k10--------
    rs1814545301,2
    --16013274(+) AAGCTA/GTCTGG 1 -- us2k10--------
    rs729064611,2
    C--16013319(+) TCTGAG/AGAGGT 1 -- us2k12Minor allele frequency- A:0.05WA 120
    rs1384015521,2
    --16013343(+) AGGGCC/TTGCAT 1 -- us2k10--------
    rs1895494631,2
    --17732797(+) GGGAGA/CGTGTC 2 -- int10--------
    rs1807468781,2
    --17732903(+) CGGGGA/CCTGAC 2 -- int10--------
    rs1131932221,2
    C--17732965(+) GGATGCCT/-CCTCC 2 -- cds11Minor allele frequency- -:0.50CSA 2
    rs106953081,2
    C--17732967(+) CCTCC-/TCCCATGA 2 -- cds10--------
    rs2006931841,2
    C--17732971(-) GTCATA/GGNNNN 2 -- int10--------
    rs38389491,2
    C--17733051(-) GACAG-/AGTCAGT 2 -- int12Minor allele frequency- AG:0.25NA 4

    HapMap Linkage Disequilibrium report for RCC2 (17733251 - 17766220 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RCC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821932CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609587    OMIM disorders: --

    2 diseases for RCC2:    About MalaCards
    basal cell carcinoma    melanoma


    RCC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RCC2
    Human Genome Epidemiology (HuGE) Navigator: RCC2 (1 document)

    Export disorders for RCC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCC2 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with RCC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. (PubMed id 12919680)1, 2, 3, 9 Mollinari C.... Margolis R.L. (2003)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PubMed id 18849993)1, 4 Stacey S.N....Stefansson K. (2008)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    7. Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis. (PubMed id 9914378)1, 2 Martineau-Thuillier S.... Margolis R.L. (1998)
    8. Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery. (PubMed id 7559776)1, 2 Martineau S.N.... Margolis R.L. (1995)
    9. Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis. (PubMed id 1939370)1, 2 Andreassen P.R.... Margolis R.L. (1991)
    10. TD-60 is required for interphase cell cycle progressio n. (PubMed id 23388455)1 Yenjerla M....Margolis R.L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55920 HGNC: 30297 AceView: TD-60 Ensembl:ENSG00000179051 euGenes: HUgn55920
    ECgene: RCC2 H-InvDB: RCC2

    (According to HUGE)
    About This Section
    HUGE: KIAA1470

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCC2 gene:
    Search GeneIP for patents involving RCC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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