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Aliases for RCC2 Gene

Aliases for RCC2 Gene

  • Regulator Of Chromosome Condensation 2 2 3
  • Telophase Disk Protein Of 60 KDa 3 4
  • RCC1-Like Protein TD-60 3 4
  • Protein RCC2 3
  • KIAA1470 4
  • TD-60 3
  • TD60 4

External Ids for RCC2 Gene

Previous GeneCards Identifiers for RCC2 Gene

  • GC01M017479
  • GC01M017605
  • GC01M017733
  • GC01M015979

Summaries for RCC2 Gene

GeneCards Summary for RCC2 Gene

RCC2 (Regulator Of Chromosome Condensation 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. An important paralog of this gene is RCBTB2.

UniProtKB/Swiss-Prot for RCC2 Gene

  • Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Wiki entry for RCC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCC2 Gene

Genomics for RCC2 Gene

Regulatory Elements for RCC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RCC2 Gene

17,406,755 bp from pter
17,439,754 bp from pter
33,000 bases
Minus strand

Genomic View for RCC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCC2 Gene

Proteins for RCC2 Gene

  • Protein details for RCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RCC2
    Protein Accession:
    Secondary Accessions:
    • Q8IVL9
    • Q9BSN6
    • Q9NPV8

    Protein attributes for RCC2 Gene

    522 amino acids
    Molecular mass:
    56085 Da
    Quaternary structure:
    • Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules.
    • Sequence=BAA95994.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB94882.1; Type=Frameshift; Positions=477; Evidence={ECO:0000305};

neXtProt entry for RCC2 Gene

Proteomics data for RCC2 Gene at MOPED

Post-translational modifications for RCC2 Gene

  • Ubiquitination at Lys92, Lys293, Lys320, Lys349, and Lys377
  • Modification sites at PhosphoSitePlus

Other Protein References for RCC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RCC2 (TD-60)

No data available for DME Specific Peptides for RCC2 Gene

Domains for RCC2 Gene

Protein Domains for RCC2 Gene

Suggested Antigen Peptide Sequences for RCC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 RCC1 repeats.
  • Contains 7 RCC1 repeats.
genes like me logo Genes that share domains with RCC2: view

No data available for Gene Families for RCC2 Gene

Function for RCC2 Gene

Molecular function for RCC2 Gene

UniProtKB/Swiss-Prot Function:
Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Ontology (GO) - Molecular Function for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22282019
GO:0008017 microtubule binding IMP 12919680
GO:0019901 protein kinase binding IPI 25074804
GO:0019904 protein domain specific binding IPI 25074804
GO:0031267 small GTPase binding IPI 25074804
genes like me logo Genes that share ontologies with RCC2: view

Phenotypes for RCC2 Gene

genes like me logo Genes that share phenotypes with RCC2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RCC2 Gene

Localization for RCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCC2 Gene

Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.

Subcellular locations from

Jensen Localization Image for RCC2 Gene COMPARTMENTS Subcellular localization image for RCC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
GO:0016020 colocalizes_with membrane IDA 25074804
genes like me logo Genes that share ontologies with RCC2: view

Pathways for RCC2 Gene

genes like me logo Genes that share pathways with RCC2: view

Pathways by source for RCC2 Gene

Gene Ontology (GO) - Biological Process for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007032 endosome organization IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007229 integrin-mediated signaling pathway IDA 19738201
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RCC2: view

Drugs for RCC2 Gene

(3) HMDB Compounds for RCC2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RCC2: view

Transcripts for RCC2 Gene

Unigene Clusters for RCC2 Gene

Regulator of chromosome condensation 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15
SP2: - -

Relevant External Links for RCC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RCC2 Gene

mRNA expression in normal human tissues for RCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RCC2 Gene

This gene is overexpressed in Lymph node (14.6), Peripheral blood mononuclear cells (9.4), Amniocyte (8.5), and Fetal ovary (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCC2 Gene

SOURCE GeneReport for Unigene cluster for RCC2 Gene Hs.380857

genes like me logo Genes that share expressions with RCC2: view

Expression partners for RCC2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RCC2 Gene

Orthologs for RCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RCC2 35
  • 90.77 (n)
  • 97.88 (a)
RCC2 36
  • 99 (a)
(Canis familiaris)
Mammalia RCC2 35
  • 91.88 (n)
  • 98.83 (a)
RCC2 36
  • 99 (a)
(Mus musculus)
Mammalia Rcc2 35
  • 87.69 (n)
  • 96.35 (a)
Rcc2 16
Rcc2 36
  • 96 (a)
(Pan troglodytes)
Mammalia RCC2 35
  • 99.3 (n)
  • 99.77 (a)
RCC2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rcc2 35
  • 86.96 (n)
  • 96.96 (a)
(Monodelphis domestica)
Mammalia RCC2 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RCC2 36
  • 97 (a)
(Gallus gallus)
Aves RCC2 35
  • 83.61 (n)
  • 94.15 (a)
RCC2 36
  • 90 (a)
(Anolis carolinensis)
Reptilia RCC2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494942 35
  • 78.11 (n)
  • 88.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7388 35
(Danio rerio)
Actinopterygii rcc2 35
  • 72.37 (n)
  • 82.89 (a)
rcc2 36
  • 81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8430 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002151 35
  • 54.44 (n)
  • 48.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9135 35
  • 52.74 (n)
  • 46.41 (a)
CG9135 36
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G19880 35
  • 48.52 (n)
  • 39.9 (a)
(Oryza sativa)
Liliopsida Os04g0662800 35
  • 47.95 (n)
  • 42.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2242 36
  • 50 (a)
Species with no ortholog for RCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCC2 Gene

Gene Tree for RCC2 (if available)
Gene Tree for RCC2 (if available)

Paralogs for RCC2 Gene

Paralogs for RCC2 Gene

genes like me logo Genes that share paralogs with RCC2: view

Variants for RCC2 Gene

Sequence variations from dbSNP and Humsavar for RCC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs730153 -- 17,423,008(+) TGCCC(A/G)CTGGA intron-variant
rs750636 -- 17,408,770(-) TTCCT(C/T)TCCTG utr-variant-3-prime
rs942457 -- 17,413,090(-) AGAAT(C/T)CGGAG reference, synonymous-codon
rs942458 -- 17,412,817(-) AAATA(A/C)ACAAG intron-variant
rs1052580 -- 17,407,975(+) TTGAC(A/G)AGGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RCC2 Gene

Variant ID Type Subtype PubMed ID
nsv821932 CNV Gain 20364138

Relevant External Links for RCC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCC2 Gene

Disorders for RCC2 Gene

Relevant External Links for RCC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RCC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RCC2 Gene

Publications for RCC2 Gene

  1. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. (PMID: 12919680) Mollinari C. … Margolis R.L. (Dev. Cell 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery. (PMID: 7559776) Martineau S.N. … Margolis R.L. (J. Cell Biol. 1995) 3 4
  5. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PMID: 18849993) Stacey S.N. … Stefansson K. (Nat. Genet. 2008) 3 48

Products for RCC2 Gene

Sources for RCC2 Gene

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