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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCC1 Gene

protein-coding   GIFtS: 65
GCID: GC01P028834

Regulator Of Chromosome Condensation 1

(Previous name: chromosome condensation 1)
(Previous symbol: CHC1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Regulator Of Chromosome Condensation 11 2     SNHG3-RCC12
CHC11 2 3 5     Guanine Nucleotide-Releasing Protein2
Cell Cycle Regulatory Protein2 3     Regulator Of Chromosome Condensation2
Chromosome Condensation 11     SNHG3-RCC1 Readthrough Transcript2
RCC1-I2     Chromosome Condensation Protein 13

External Ids:    HGNC: 19131   Entrez Gene: 11042   Ensembl: ENSG000001801987   OMIM: 1797105   UniProtKB: P187543   
ORGUL members:         
NONCODE14:n381089 n343016 n408890      

Export aliases for RCC1 gene to outside databases

Previous GC identifers: GC01P028659 GC01P028665 GC01P028705 GC01P028717 GC01P027086


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RCC1 Gene: 
RCC1 (regulator of chromosome condensation 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RCC1 include raynaud disease, and vaccinia, and among its related super-pathways are HIV Life Cycle and Interactions of Rev with host cellular proteins. GO annotations related to this gene include chromatin binding and nucleosomal DNA binding. An important paralog of this gene is SERGEF.

UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754
Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the
regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded
DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that
detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly

Gene Wiki entry for RCC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCC1 gene promoter:
         NF-kappaB1   Nkx5-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RCC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

RCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028834:  view genomic region     (about GC identifiers)

Start:
28,832,455 bp from pter      End:
28,865,812 bp from pter
Size:
33,358 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RCC1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754 (See protein sequence)
Recommended Name: Regulator of chromosome condensation  
Size: 421 amino acids; 44969 Da
Subunit: Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation
Subcellular location: Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis
Miscellaneous: Patients with Raynaud disease produce antibodies that bind to RCC1
2 PDB 3D structures from and Proteopedia for RCC1:
1A12 (3D)        1I2M (3D)    
Secondary accessions: Q16269 Q6NT97
Alternative splicing: 2 isoforms:  P18754-1   P18754-2   

Explore the universe of human proteins at neXtProt for RCC1: NX_P18754

Explore proteomics data for RCC1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin
    association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitate
    electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps
    retain RCC1 on chromosomes during nucleotide exchange on Ran
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18754

  • RCC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCC1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001041659.1  NP_001041660.1  NP_001041664.1  NP_001260.1  

    ENSEMBL proteins: 
     ENSP00000402740   ENSP00000405258   ENSP00000362939   ENSP00000402260   ENSP00000362938  
     ENSP00000362937   ENSP00000413644   ENSP00000472057   ENSP00000394650   ENSP00000381931  
    Reactome Protein details: P18754
    Human Recombinant Protein Products for RCC1: 
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    Novus Biologicals RCC1 Proteins
    Novus Biologicals RCC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RCC1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA15014043
    GO:0000794condensed nuclear chromosome IDA15014043
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    RCC1 for ontologies           About GeneDecksing



    RCC1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RCC1
    Browse R&D Systems for Antibodies
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    Novus Biologicals RCC1 Antibodies
    Abcam antibodies for RCC1
    Cloud-Clone Corp. Antibodies for RCC1 
    ThermoFisher Antibody for RCC1
    LSBio Antibodies in human, mouse, rat for RCC1 

    Assay Products for RCC1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RCC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RCC1 
    Cloud-Clone Corp. CLIAs for RCC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry P18754

    ProtoNet protein and cluster: P18754

    1 Blocks protein domain: IPB000408 Regulator of chromosome condensation

    UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754
    Similarity: Contains 7 RCC1 repeats


    RCC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCC1_HUMAN, P18754
    Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the
    regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded
    DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that
    detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA2677018
    GO:0005087Ran guanyl-nucleotide exchange factor activity IDA1944575
    GO:0005515protein binding IPI11336674
    GO:0031492nucleosomal DNA binding IDA17435751
    GO:0042393histone binding IDA11375490
         
    RCC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RCC1:
     Nuclear 60S biogenesis defects  Nuclear pre-40S maturation def 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCC1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCC1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RCC1 (see all 23):
    hsa-miR-16-2* hsa-miR-137 hsa-miR-4272 hsa-miR-340 hsa-miR-218 hsa-miR-548a-3p hsa-miR-4314 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidRCC1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCC1
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                         Customized lentivirus expression plasmids for stable overexpression of RCC1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RCC1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.94
    Interactions of Rev with host cellular proteins0.94
    Nuclear import of Rev protein0.94
    3Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94
    4DNA Damage
    Cell Cycle / Checkpoint Control0.32
    5Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RCC1
        Cell cycle Spindle assembly and chromosome separation


    2 Cell Signaling Technology (CST) Pathways for RCC1
        Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RCC1
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for RCC1
        Validated targets of C-MYC transcriptional activation

    5/8        Reactome Pathways for RCC1 (see all 8)
        Nuclear import of Rev protein
    Late Phase of HIV Life Cycle
    Interactions of Rev with host cellular proteins
    Disease
    Host Interactions of HIV factors



    RCC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RCC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/157 Interacting proteins for RCC1 (P187541, 2, 3 ENSP000003629374) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=3 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IMP3678831
    GO:0007052mitotic spindle organization IDA15014043
    GO:0007059chromosome segregation IMP17435751
    GO:0007067mitosis IEA--
    GO:0007088regulation of mitosis IDA15014043

    RCC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RCC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCC1

    1 HMDB Compound for RCC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for RCC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 71 9 7548002 (2), 10911995 (2), 9398678 (1), 12494999 (1) (see all 5)
    gdp 70.8 5 7548002 (2), 9398678 (1), 10911995 (1)

    Search CenterWatch for drugs/clinical trials and news about RCC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCC1 gene (4 alternative transcripts): 
    NM_001048194.2  NM_001048195.2  NM_001048199.2  NM_001269.4  

    Unigene Cluster for RCC1:

    Regulator of chromosome condensation 1
    Hs.469723  [show with all ESTs]
    Unigene Representative Sequence: NR_030725
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427469 ENST00000434290 ENST00000373833 ENST00000419074 ENST00000373832
    ENST00000373831 ENST00000411533 ENST00000486790 ENST00000430407 ENST00000429051
    ENST00000478232 ENST00000398958(uc001bqb.2 uc001bqa.2 uc001bqc.2 uc001bqe.2 uc001bqf.2 uc001bqg.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCC1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RCC1 (see all 23):
    hsa-miR-16-2* hsa-miR-137 hsa-miR-4272 hsa-miR-340 hsa-miR-218 hsa-miR-548a-3p hsa-miR-4314 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidRCC1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCC1
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCC1

    Additional mRNA sequence: 

    AF075052.1 AF498924.1 AJ006834.1 AJ006835.1 AK092726.1 AK311577.1 BC001589.1 BC006790.1 
    BC007300.1 BC010067.2 BC012122.1 BC017334.2 BC036903.1 BC065008.1 BC069198.1 CR407693.1 
    NR_002909.2 NR_030725.1 NR_030726.1 NR_036473.1 S75708.1 X06130.1 X12654.1 

    24 DOTS entries:

    DT.116202  DT.95327866  DT.97801136  DT.95327877  DT.100797105  DT.100797098  DT.100797106  DT.95327876 
    DT.100022007  DT.100742853  DT.91756238  DT.100022008  DT.86850191  DT.100797104  DT.97841265  DT.95256807 
    DT.100783018  DT.100797088  DT.100797103  DT.95327874  DT.95327880  DT.100783021  DT.121408192  DT.91706060 

    24/326 AceView cDNA sequences (see all 326):

    BX404402 BX420738 NM_001269 BU183513 BU522008 AJ006834 AA705507 BU501614 
    BC001589 BM993043 AA313518 BX383560 CR407693 BQ642961 CB157773 BI818114 
    BQ053548 BG257155 BU622451 AA321661 BM790281 BQ224465 BX416625 BU624721 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RCC1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                                                                                      -                       -                       -                     
    SP2:                                                        -     -                       -                       -                       -                     
    SP3:                                                        -     -                                               -                                             
    SP4:                                                              -                       -                                                                     
    SP5:                                                              -                       -                       -                                             

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RCC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCC1 expression in normal human tissues (normalized intensities)      RCC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTTGCTCA
    RCC1 Expression
    About this image


    RCC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             seminal vesicle ; glandular cells   
             sperm   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See RCC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCC1

    SOURCE GeneReport for Unigene cluster: Hs.469723
        SABiosciences Custom PCR Arrays for RCC1
    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RCC1 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcc11 , 5 regulator of chromosome condensation 11, 5 89.15(n)1
    93.82(a)1
      4 (65.20 cM)5
    1000881  NM_133878.31  NP_598639.11 
     1323319195 
    chicken
    (Gallus gallus)
    Aves RCC11 regulator of chromosome condensation 1 75.38(n)
    80.34(a)
      429810  XM_427366.3  XP_427366.3 
    lizard
    (Anolis carolinensis)
    Reptilia RCC16
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343904.1(128858-138750)
    African clawed frog
    (Xenopus laevis)
    Amphibia D00646.12   -- 75.35(n)    D00646.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059796.12   -- 76.36(n)    BC059796.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bj11 Bj1 protein 50.51(n)
    44.64(a)
      38669  NM_079219.3  NP_523943.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ran-31 Protein RAN-3 44.44(n)
    36.56(a)
      174332  NM_063352.3  NP_495753.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRM1(YGL097W)4
    SRM11
    Nucleotide exchange factor for Gsp1p, localizes to more4
    Srm1p1
    42.69(n)1
    33.33(a)1
      7(321782-323230)4
    8527821, 4  NP_011418.11, 4 


    ENSEMBL Gene Tree for RCC1 (if available)
    TreeFam Gene Tree for RCC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCC1 gene
    SERGEF2  RCC22  RCBTB22  IBTK2  WBSCR162  RPGR2  RCBTB12  
    3 SIMAP similar genes for RCC1 using alignment to 9 protein entries:     RCC1_HUMAN (see all proteins):
    HERC6    HERC3    HERC4

    RCC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RCC1
    PGOHUM00000243201


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/675 SNPs in RCC1 are shown (see all 675)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114313311,2
    C--28837941(+) AGTCT-/TCGCTC 3 -- int10--------
    rs1897568091,2
    --28837944(+) GTCTCA/GCTCTG 3 -- int10--------
    rs617859801,2
    C,F--28837951(+) TCTGTT/CGCCCA 3 -- int12Minor allele frequency- C:0.25NA WA 4
    rs1425316021,2
    --28838033(+) ACGCCA/GCCACA 3 -- int10--------
    rs1818575321,2
    --28838124(+) GATCCA/GCCCAC 3 -- int10--------
    rs1858248751,2
    --28838133(+) ACCTCA/GGCCTC 3 -- int10--------
    rs28537361,2
    C--28838198(+) agatcA/G/Taatct 3 -- int13NA WA 240
    rs1903214451,2
    --28838283(+) TTCTCC/TCACCT 3 -- int10--------
    rs1819056751,2
    --28838352(+) TGCATA/TTTTTA 3 -- int10--------
    rs1460405881,2
    --28838366(+) GAGACA/GGGTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for RCC1 (28832455 - 28865812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RCC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657760CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179710    OMIM disorders: --

    8 diseases for RCC1:    About MalaCards
    raynaud disease    vaccinia    attention deficit hyperactivity disorder    retinitis pigmentosa
    herpes simplex    retinoblastoma    retinitis    lateral sclerosis

    1 disease from the University of Copenhagen DISEASES database for RCC1:
    Retinoblastoma

    RCC1 for disorders           About GeneDecksing


    Export disorders for RCC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCC1 gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with RCC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. (PubMed id 1944575)1, 2, 9 Bischoff F.R. and Ponstingl H. (1991)
    2. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. (PubMed id 20668449)1, 2 Tooley C.E.... Macara I.G. (2010)
    3. Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1. (PubMed id 18762580)1, 2 Hao Y. and Macara I.G. (2008)
    4. N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. (PubMed id 17435751)1, 2 Chen T....Macara I.G. (2007)
    5. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). (PubMed id 11336674)1, 2 Renault L....Wittinghofer A. (2001)
    9. The 1.7-A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. (PubMed id 9510255)1, 2 Renault L....Wittinghofer A. (1998)
    10. Mammalian cells have two functional RCC1 proteins produced by alternative splicing. (PubMed id 7983178)1, 2 Miyabashira J.... Nishimoto T. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1104 HGNC: 1913 AceView: CHC1 Ensembl:ENSG00000180198 euGenes: HUgn1104
    ECgene: RCC1 H-InvDB: RCC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCC1 gene:
    Search GeneIP for patents involving RCC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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