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Aliases for RCC1 Gene

Aliases for RCC1 Gene

  • Regulator Of Chromosome Condensation 1 2 3
  • Cell Cycle Regulatory Protein 3 4
  • CHC1 3 4
  • Guanine Nucleotide-Releasing Protein 3
  • Regulator Of Chromosome Condensation 3
  • Chromosome Condensation Protein 1 4
  • Chromosome Condensation 1 2
  • SNHG3-RCC1 Readthrough 3
  • SNHG3-RCC1 3
  • RCC1-I 3
  • CHC1, 6

External Ids for RCC1 Gene

Previous Symbols for RCC1 Gene

  • CHC1

Summaries for RCC1 Gene

GeneCards Summary for RCC1 Gene

RCC1 (Regulator Of Chromosome Condensation 1) is a Protein Coding gene. Among its related pathways are Disease and Cytoskeletal Signaling. GO annotations related to this gene include chromatin binding and nucleosomal DNA binding. An important paralog of this gene is RCBTB2.

UniProtKB/Swiss-Prot for RCC1 Gene

  • Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.

Gene Wiki entry for RCC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCC1 Gene

Genomics for RCC1 Gene

Genomic Location for RCC1 Gene

Start:
28,505,943 bp from pter
End:
28,539,300 bp from pter
Size:
33,358 bases
Orientation:
Plus strand

Genomic View for RCC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCC1 Gene

Regulatory Elements for RCC1 Gene

Proteins for RCC1 Gene

  • Protein details for RCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18754-RCC1_HUMAN
    Recommended name:
    Regulator of chromosome condensation
    Protein Accession:
    P18754
    Secondary Accessions:
    • Q16269
    • Q6NT97

    Protein attributes for RCC1 Gene

    Size:
    421 amino acids
    Molecular mass:
    44969 Da
    Quaternary structure:
    • Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.
    Miscellaneous:
    • Patients with Raynaud disease produce antibodies that bind to RCC1

    Three dimensional structures from OCA and Proteopedia for RCC1 Gene

    Alternative splice isoforms for RCC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCC1 Gene

Proteomics data for RCC1 Gene at MOPED

Post-translational modifications for RCC1 Gene

  • N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys161 and Lys335

No data available for DME Specific Peptides for RCC1 Gene

Domains for RCC1 Gene

Protein Domains for RCC1 Gene

UniProtKB/Swiss-Prot:

RCC1_HUMAN
Similarity:
  • Contains 7 RCC1 repeats.:
    • P18754
genes like me logo Genes that share domains with RCC1: view

No data available for Gene Families for RCC1 Gene

Function for RCC1 Gene

Molecular function for RCC1 Gene

UniProtKB/Swiss-Prot Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.

Gene Ontology (GO) - Molecular Function for RCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 2677018
GO:0005087 Ran guanyl-nucleotide exchange factor activity IDA 1944575
GO:0005515 protein binding IPI 11336674
GO:0031492 nucleosomal DNA binding IDA 17435751
GO:0042393 histone binding IDA 11375490
genes like me logo Genes that share ontologies with RCC1: view

Phenotypes for RCC1 Gene

genes like me logo Genes that share phenotypes with RCC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RCC1 Gene

Localization for RCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCC1 Gene

Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCC1 Gene COMPARTMENTS Subcellular localization image for RCC1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 15014043
GO:0000794 condensed nuclear chromosome IDA 15014043
GO:0005634 nucleus IDA 17435751
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 17435751
genes like me logo Genes that share ontologies with RCC1: view

Pathways for RCC1 Gene

genes like me logo Genes that share pathways with RCC1: view

Pathways by source for RCC1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RCC1 Gene
2 Qiagen pathways for RCC1 Gene
2 Cell Signaling Technology pathways for RCC1 Gene

Gene Ontology (GO) - Biological Process for RCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 3678831
GO:0007052 mitotic spindle organization IDA 15014043
GO:0007059 chromosome segregation IMP 17435751
GO:0007067 mitotic nuclear division IEA --
GO:0007088 regulation of mitotic nuclear division IDA 15014043
genes like me logo Genes that share ontologies with RCC1: view

Compounds for RCC1 Gene

(1) HMDB Compounds for RCC1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for RCC1 Gene

Compound -log(P) Hits PubMed IDs
gtp 71 7
gdp 70.8 4
genes like me logo Genes that share compounds with RCC1: view

Transcripts for RCC1 Gene

Unigene Clusters for RCC1 Gene

Regulator of chromosome condensation 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a ·
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: -
SP7: -
SP8:
SP9: - -
SP10: -

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for RCC1 Gene

GeneLoc Exon Structure for
RCC1
ECgene alternative splicing isoforms for
RCC1

Expression for RCC1 Gene

mRNA expression in normal human tissues for RCC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCC1 Gene

SOURCE GeneReport for Unigene cluster for RCC1 Gene Hs.469723

genes like me logo Genes that share expressions with RCC1: view

Orthologs for RCC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCC1 36
  • 99.6 (n)
  • 99.76 (a)
RCC1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RCC1 36
  • 90.89 (n)
  • 95.25 (a)
RCC1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCC1 36
  • 91.77 (n)
  • 96.44 (a)
RCC1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcc1 36
  • 89.15 (n)
  • 93.82 (a)
Rcc1 16
Rcc1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RCC1 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCC1 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rcc1 36
  • 89.31 (n)
  • 93.35 (a)
chicken
(Gallus gallus)
Aves RCC1 36
  • 75.38 (n)
  • 80.34 (a)
RCC1 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCC1 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcc1 36
  • 68.27 (n)
  • 77.46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5005 36
zebrafish
(Danio rerio)
Actinopterygii rcc1 36
  • 70.26 (n)
  • 74.4 (a)
rcc1 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003742 36
  • 52.83 (n)
  • 47.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bj1 36
  • 50.85 (n)
  • 44.64 (a)
Bj1 37
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ran-3 36
  • 44.6 (n)
  • 36.34 (a)
ran-3 37
  • 25 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL045C 36
  • 44.79 (n)
  • 33.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRM1 36
  • 43.32 (n)
  • 33.42 (a)
SRM1 37
  • 25 (a)
OneToMany
SRM1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06600g 36
  • 40.97 (n)
  • 32.35 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05513 36
  • 47.16 (n)
  • 36.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pim1 36
  • 43.72 (n)
  • 37.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2815 37
  • 42 (a)
OneToOne
Species with no ortholog for RCC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCC1 Gene

ENSEMBL:
Gene Tree for RCC1 (if available)
TreeFam:
Gene Tree for RCC1 (if available)

Paralogs for RCC1 Gene

Paralogs for RCC1 Gene

Selected SIMAP similar genes for RCC1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for RCC1 Gene

genes like me logo Genes that share paralogs with RCC1: view

Variants for RCC1 Gene

Sequence variations from dbSNP and Humsavar for RCC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs762447 -- 28,521,076(+) tccat(C/G)tcaaa intron-variant
rs2014623 -- 28,523,847(+) gtttc(A/T)ctctt intron-variant
rs2066726 -- 28,535,124(+) GATGT(A/G)CCTGT synonymous-codon, reference, nc-transcript-variant
rs2097191 -- 28,530,779(+) AATGC(C/G)CCTGT intron-variant
rs2097192 -- 28,530,780(+) ATGCG(C/G)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCC1 Gene

Variant ID Type Subtype PubMed ID
esv2657760 CNV Deletion 23128226

Relevant External Links for RCC1 Gene

HapMap Linkage Disequilibrium report
RCC1

Disorders for RCC1 Gene

(1) University of Copenhagen DISEASES for RCC1 Gene

genes like me logo Genes that share disorders with RCC1: view

No data available for UniProtKB/Swiss-Prot for RCC1 Gene

Publications for RCC1 Gene

  1. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. (PMID: 1944575) Bischoff F.R. … Ponstingl H. (Nature 1991) 3 4 23
  2. Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1. (PMID: 8896453) Noguchi E. … Nishimoto T. (EMBO J. 1996) 3 23
  3. Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B. (PMID: 11375490) Nemergut M.E. … Macara I.G. (Science 2001) 3 23
  4. Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. (PMID: 11932251) Nemergut M.E. … Macara I.G. (J. Biol. Chem. 2002) 3 23
  5. Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. (PMID: 15014043) Li H.Y. … Zheng Y. (Genes Dev. 2004) 3 23

Products for RCC1 Gene

Sources for RCC1 Gene

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