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RCC1 Gene

protein-coding   GIFtS: 65
GCID: GC01P028834

Regulator Of Chromosome Condensation 1

(Previous name: chromosome condensation 1)
(Previous symbol: CHC1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of Chromosome Condensation 11 2     SNHG3-RCC12
CHC11 2 3 5     Guanine Nucleotide-Releasing Protein2
Cell Cycle Regulatory Protein2 3     Regulator Of Chromosome Condensation2
Chromosome Condensation 11     SNHG3-RCC1 Readthrough2
RCC1-I2     Chromosome Condensation Protein 13

External Ids:    HGNC: 19131   Entrez Gene: 11042   Ensembl: ENSG000001801987   OMIM: 1797105   UniProtKB: P187543   

Export aliases for RCC1 gene to outside databases

Previous GC identifers: GC01P028659 GC01P028665 GC01P028705 GC01P028717 GC01P027086


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RCC1 Gene:
RCC1 (regulator of chromosome condensation 1) is a protein-coding gene. GO annotations related to this gene include chromatin binding and nucleosomal DNA binding. An important paralog of this gene is SERGEF.

UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754
Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the
regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded
DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that
detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly

Gene Wiki entry for RCC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RCC1 gene promoter:
         NF-kappaB1   Nkx5-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RCC1 promoter sequence
   Search Chromatin IP Primers for RCC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

RCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028834:  view genomic region     (about GC identifiers)

Start:
28,832,455 bp from pter      End:
28,865,812 bp from pter
Size:
33,358 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RCC1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754 (See protein sequence)
Recommended Name: Regulator of chromosome condensation  
Size: 421 amino acids; 44969 Da
Subunit: Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation
Miscellaneous: Patients with Raynaud disease produce antibodies that bind to RCC1
2 PDB 3D structures from and Proteopedia for RCC1:
1A12 (3D)        1I2M (3D)    
Secondary accessions: Q16269 Q6NT97
Alternative splicing: 2 isoforms:  P18754-1   P18754-2   

Explore the universe of human proteins at neXtProt for RCC1: NX_P18754

Explore proteomics data for RCC1 at MOPED

Post-translational modifications: 

  • N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin
    association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitate
    electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps
    retain RCC1 on chromosomes during nucleotide exchange on Ran1
  • Ubiquitination2 at Lys161, Lys335
  • Modification sites at PhosphoSitePlus

  • See RCC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001041659.1  NP_001041660.1  NP_001041664.1  NP_001260.1  

    ENSEMBL proteins: 
     ENSP00000402740   ENSP00000405258   ENSP00000362939   ENSP00000402260   ENSP00000362938  
     ENSP00000362937   ENSP00000413644   ENSP00000472057   ENSP00000394650   ENSP00000381931  
    Reactome Protein details: P18754

    RCC1 Human Recombinant Protein Products:

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    Novus Biologicals RCC1 Proteins
    Novus Biologicals RCC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RCC1

     
    Search eBioscience for Proteins for RCC1 

     
    antibodies-online proteins for RCC1 (9 products) 

     
    antibodies-online peptides for RCC1

    RCC1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RCC1
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    Abcam antibodies for RCC1
    Cloud-Clone Corp. Antibodies for RCC1
    ThermoFisher Antibody for RCC1
    antibodies-online antibodies for RCC1 (78 products) 

    RCC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RCC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RCC1
    Cloud-Clone Corp. CLIAs for RCC1
    Search eBioscience for ELISAs for RCC1 
    antibodies-online kits for RCC1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry P18754

    ProtoNet protein and cluster: P18754

    1 Blocks protein domain: IPB000408 Regulator of chromosome condensation

    UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754
    Similarity: Contains 7 RCC1 repeats


    Find genes that share domains with RCC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCC1_HUMAN, P18754
    Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the
    regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded
    DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that
    detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA2677018
    GO:0005087Ran guanyl-nucleotide exchange factor activity IDA1944575
    GO:0005515protein binding IPI11336674
    GO:0031492nucleosomal DNA binding IDA17435751
    GO:0042393histone binding IDA11375490
         
    Find genes that share ontologies with RCC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RCC1:
     Nuclear 60S biogenesis defects  Nuclear pre-40S maturation def 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RCC1

    miRNA
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    miRTarBase miRNAs that target RCC1:
    hsa-mir-941 (MIRT036582), hsa-mir-18a-3p (MIRT040885), hsa-mir-149-5p (MIRT045518), hsa-mir-193b-3p (MIRT016531), hsa-mir-92a-3p (MIRT049090), hsa-mir-124-3p (MIRT023213)

    Block miRNA regulation of human, mouse, rat RCC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RCC1 (see all 23):
    hsa-miR-16-2* hsa-miR-137 hsa-miR-4272 hsa-miR-340 hsa-miR-218 hsa-miR-548a-3p hsa-miR-4314 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidRCC1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RCC1
    Predesigned siRNA for gene silencing in human, mouse, rat RCC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): RCC1 (NM_001048199)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RCC1_HUMAN, P18754: Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA15014043
    GO:0000794condensed nuclear chromosome IDA15014043
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with RCC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RCC1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.91
    Interactions of Rev with host cellular proteins0.91
    Nuclear import of Rev protein0.91
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    4Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation
    5Disease
    Disease


    Find genes that share SuperPaths with RCC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RCC1
        Ran Pathway
    SUMO Pathway

    2 Cell Signaling Technology (CST) Pathways for RCC1
        Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RCC1
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for RCC1
        Validated targets of C-MYC transcriptional activation

    2 Reactome Pathways for RCC1
        Rev-mediated nuclear export of HIV RNA
    Nuclear import of Rev protein


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RCC1
    Interactions:

        GeneGlobe Interaction Network for RCC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RCC1 (P187541, 2, 3 ENSP000003629374) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=3 STRING: ENSP00000352980
    HIST1H4FP628053, ENSP000003669744I2D: score=3 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=3 STRING: ENSP00000289352
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IMP3678831
    GO:0007052mitotic spindle organization IDA15014043
    GO:0007059chromosome segregation IMP17435751
    GO:0007067mitosis IEA--
    GO:0007088regulation of mitosis IDA15014043

    Find genes that share ontologies with RCC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RCC1

    1 HMDB Compound for RCC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for RCC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 71 9 7548002 (2), 10911995 (2), 9398678 (1), 12494999 (1) (see all 5)
    gdp 70.8 5 7548002 (2), 9398678 (1), 10911995 (1)



    Find genes that share compounds with RCC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RCC1 gene (4 alternative transcripts): 
    NM_001048194.2  NM_001048195.2  NM_001048199.2  NM_001269.4  

    Unigene Cluster for RCC1:

    Regulator of chromosome condensation 1
    Hs.469723  [show with all ESTs]
    Unigene Representative Sequence: NR_030725
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427469 ENST00000434290 ENST00000373833 ENST00000419074 ENST00000373832
    ENST00000373831 ENST00000411533 ENST00000486790 ENST00000430407 ENST00000429051
    ENST00000478232 ENST00000398958(uc001bqb.2 uc001bqa.2 uc001bqc.2 uc001bqe.2 uc001bqf.2 uc001bqg.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat RCC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RCC1 (see all 23):
    hsa-miR-16-2* hsa-miR-137 hsa-miR-4272 hsa-miR-340 hsa-miR-218 hsa-miR-548a-3p hsa-miR-4314 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidRCC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RCC1
    Clone
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    OriGene clones in human, mouse for RCC1 (see all 19)
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    GenScript: all cDNA clones in your preferred vector (see all 4): RCC1 (NM_001048199)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCC1
    Primer
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    OriGene qPCR primer pairs and template standards for RCC1
    OriGene qSTAR qPCR primer pairs in human, mouse for RCC1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RCC1
      QuantiTect SYBR Green Assays in human, mouse, rat RCC1
      QuantiFast Probe-based Assays in human, mouse, rat RCC1

    Additional mRNA sequence: 

    AF075052.1 AF498924.1 AJ006834.1 AJ006835.1 AK092726.1 AK311577.1 BC001589.1 BC006790.1 
    BC007300.1 BC010067.2 BC012122.1 BC017334.2 BC036903.1 BC065008.1 BC069198.1 CR407693.1 
    NR_002909.2 NR_030725.1 NR_030726.1 NR_036473.1 S75708.1 X06130.1 X12654.1 

    24 DOTS entries:

    DT.116202  DT.95327866  DT.97801136  DT.95327877  DT.100797105  DT.100797098  DT.100797106  DT.95327876 
    DT.100022007  DT.100742853  DT.91756238  DT.100022008  DT.86850191  DT.100797104  DT.97841265  DT.95256807 
    DT.100783018  DT.100797088  DT.100797103  DT.95327874  DT.95327880  DT.100783021  DT.121408192  DT.91706060 

    Selected AceView cDNA sequences (see all 326):

    BC007300 AI937907 AA977522 BQ446933 BG257155 NM_001269 CB157773 BQ053548 
    AI921730 BC065008 BU624721 BE831173 CR604404 AW629400 CB163464 AA705507 
    AL134800 BM824409 BU522008 BC010067 BM720744 AA313518 F05487 BM790281 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RCC1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                                                                                      -                       -                       -                     
    SP2:                                                        -     -                       -                       -                       -                     
    SP3:                                                        -     -                                               -                                             
    SP4:                                                              -                       -                                                                     
    SP5:                                                              -                       -                       -                                             

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RCC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RCC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTTGCTCA
    RCC1 Expression
    About this image


    RCC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RCC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RCC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469723
        Custom PCR Arrays for RCC1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RCC1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcc11 , 5 regulator of chromosome condensation 11, 5 89.15(n)1
    93.82(a)1
      4 (65.20 cM)5
    1000881  NM_001197082.11  NP_001184011.11 
     1323319195 
    chicken
    (Gallus gallus)
    Aves RCC11 regulator of chromosome condensation 1 75.38(n)
    80.34(a)
      429810  XM_427366.4  XP_427366.3 
    lizard
    (Anolis carolinensis)
    Reptilia RCC16
    regulator of chromosome condensation 1
    66(a)
    1 ↔ 1
    GL343904.1(128858-138750)
    African clawed frog
    (Xenopus laevis)
    Amphibia D00646.12   -- 75.35(n)    D00646.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059796.12   -- 76.36(n)    BC059796.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bj11 Bj1 protein 50.85(n)
    44.64(a)
      38669  NM_079219.3  NP_523943.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ran-31 ran-3 44.6(n)
    36.34(a)
      174332  NM_063352.4  NP_495753.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRM1(YGL097W)4
    SRM11
    Nucleotide exchange factor for Gsp1p, localizes to more4
    SRM11
    43.32(n)1
    33.42(a)1
      7(321782-323230)4
    8527821, 4  NP_011418.11, 4 


    ENSEMBL Gene Tree for RCC1 (if available)
    TreeFam Gene Tree for RCC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RCC1 gene
    SERGEF2  RCC22  RCBTB22  IBTK2  WBSCR162  RPGR2  RCBTB12  
    2 SIMAP similar genes for RCC1 using alignment to 8 protein entries:     RCC1_HUMAN (see all proteins):
    HERC4    HERC3

    Find genes that share paralogs with RCC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RCC1
    PGOHUM00000243201


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RCC1 (see all 675)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114313311,2
    C--28837941(+) AGTCT-/TCGCTC 3 -- int10--------
    rs1897568091,2
    --28837944(+) GTCTCA/GCTCTG 3 -- int10--------
    rs617859801,2
    C,F--28837951(+) TCTGTT/CGCCCA 3 -- int12Minor allele frequency- C:0.25NA WA 4
    rs1425316021,2
    --28838033(+) ACGCCA/GCCACA 3 -- int10--------
    rs1818575321,2
    --28838124(+) GATCCA/GCCCAC 3 -- int10--------
    rs1858248751,2
    --28838133(+) ACCTCA/GGCCTC 3 -- int10--------
    rs28537361,2
    C--28838198(+) agatcA/G/Taatct 3 -- int13NA WA 240
    rs1903214451,2
    --28838283(+) TTCTCC/TCACCT 3 -- int10--------
    rs1819056751,2
    --28838352(+) TGCATA/TTTTTA 3 -- int10--------
    rs1460405881,2
    --28838366(+) GAGACA/GGGTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for RCC1 (28832455 - 28865812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RCC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657760CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RCC1
    DNA2.0 Custom Variant and Variant Library Synthesis for RCC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179710    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RCC1:
    Retinoblastoma

    Find genes that share disorders with RCC1           About GenesLikeMe


    Export disorders for RCC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for RCC1 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with RCC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. (PubMed id 1944575)1, 2, 9 Bischoff F.R. and Ponstingl H. (Nature 1991)
    2. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. (PubMed id 20668449)1, 2 Tooley C.E.... Macara I.G. (Nature 2010)
    3. Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1. (PubMed id 18762580)1, 2 Hao Y. and Macara I.G. (J. Cell Biol. 2008)
    4. N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. (PubMed id 17435751)1, 2 Chen T.... Macara I.G. (Nat. Cell Biol. 2007)
    5. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (J. Cell Sci. 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). (PubMed id 11336674)1, 2 Renault L.... Wittinghofer A. (Cell 2001)
    9. The 1.7-A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. (PubMed id 9510255)1, 2 Renault L....Wittinghofer A. (Nature 1998)
    10. Mammalian cells have two functional RCC1 proteins produced by alternative splicing. (PubMed id 7983178)1, 2 Miyabashira J.... Nishimoto T. (J. Cell Sci. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1104 HGNC: 1913 AceView: CHC1 Ensembl:ENSG00000180198 euGenes: HUgn1104
    ECgene: RCC1 H-InvDB: RCC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RCC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RCC1 gene:
    Search GeneIP for patents involving RCC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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