RCC1 Gene
protein-coding GIFtS: 64
GCID: GC01P028834
|
|
regulator of chromosome condensation 1(Previous name: chromosome condensation 1 )
(Previous symbol: CHC1)
| |
Aliases
for RCC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Regulator Of Chromosome Condensation 11 2 | | SNHG3-RCC12 | | CHC11 2 3 5 | | Guanine Nucleotide-Releasing Protein2 | | Cell Cycle Regulatory Protein2 3 | | Regulator Of Chromosome Condensation2 | | Chromosome Condensation 11 | | SNHG3-RCC1 Readthrough Transcript2 | | RCC1-I2 | | Chromosome Condensation Protein 13 |
| External Ids: | HGNC: 19131 | Entrez Gene: 11042 | Ensembl: ENSG000001801987 | OMIM: 1797105 | UniProtKB: P187543 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408890 | |
Export aliases for RCC1 gene to outside databasesPrevious GC identifers: GC01P028659 GC01P028665 GC01P028705 GC01P028717 GC01P027086
Summaries
for RCC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in theregulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detectsunreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly
Gene Wiki entry for RCC1
|
Genomic Views
for RCC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RCC1 gene promoter:
NF-kappaB1 Nkx5-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RCC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.1 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35.3RCC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P028834: view genomic region
(about GC identifiers)
Start:
|
28,832,455 bp from pter |
End:
|
28,865,708 bp from pter |
Size:
|
33,254 bases |
Orientation:
|
plus strand |
|
Proteins
for RCC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754 (See
protein sequence)Recommended Name: Regulator of chromosome condensation Size: 421 amino acids; 44969 Da
Subunit: Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation
Subcellular location: Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis
Miscellaneous: Patients with Raynaud disease produce antibodies that bind to RCC1
2 PDB 3D structures from  and Proteopedia  for RCC1:1A12 (3D)
1I2M (3D)
Secondary accessions: Q16269 Q6NT97Alternative splicing: 2 isoforms: P18754-1 P18754-2 Explore the universe of human proteins at neXtProt for RCC1: NX_P18754
Post-translational modifications:
N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association.Di- and trimethylation produce a permanent positive charge on the amino group, which facilitate electrostatic bindingto the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomesduring nucleotide exchange on Ran1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P18754
RCC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001041659.1 NP_001041660.1 NP_001041664.1 NP_001260.1
ENSEMBL proteins: ENSP00000402740 ENSP00000405258 ENSP00000362939 ENSP00000402260 ENSP00000362938 ENSP00000362937 ENSP00000413644 ENSP00000394650 ENSP00000416220 ENSP00000381931 Reactome Protein details: P18754
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
RCC1 for ontologies About GeneDecksing
RCC1 Antibody Products:
Assay Products for RCC1: |
Protein
Domains /
Families
for RCC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RCC1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P18754ProtoNet protein and cluster: P18754 1 Blocks protein family: IPB000408 Regulator of chromosome condensation
UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754Similarity: Contains 7 RCC1 repeats |
Function
for RCC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RCC1_HUMAN, P18754Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in theregulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detectsunreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCC1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCC1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): RCC1 (NM_001048199) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RCC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCC1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
RCC1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RCC1:
|
Pathways & Interactions
for RCC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus | | | 2 | Cell cycle_Spindle assembly and chromosome separation | | | 3 | HIV Infection | | | 4 | Late Phase of HIV Life Cycle | | | 5 | Cytoskeletal Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for RCC1
2 
Cell Signaling Technology (CST) Pathways for RCC1
1  GeneGo (Thomson Reuters) Pathway for RCC1
1  BioSystems Pathway for RCC1
5/8 
Reactome Pathways for RCC1 (see all 8)
RCC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RCC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/145 Interacting proteins for RCC1 (P187541, 2, 3 ENSP000003629374) via UniProtKB, MINT, STRING, and/or I2D (see all 145)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
RCC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RCC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RCC1 for compounds About GeneDecksing
 Browse Tocris compounds for RCC1
1 HMDB Compound for RCC1 About this table
2 Novoseek chemical compound relationships for RCC1 gene About this table
Search CenterWatch for drugs/clinical trials and news about RCC1
|
Transcripts
for RCC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RCC1 gene (4 alternative transcripts): NM_001048194.2 NM_001048195.2 NM_001048199.2 NM_001269.4 Unigene Cluster for RCC1: Regulator of chromosome condensation 1 Hs.469723 [show with all ESTs]Unigene Representative Sequence: NR_03072512 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000427469 ENST00000434290 ENST00000373833 ENST00000419074 ENST00000373832
ENST00000373831 ENST00000411533 ENST00000486790 ENST00000430407 ENST00000429051
ENST00000478232 ENST00000398958(uc001bqb.2 uc001bqa.2 uc001bqc.2 uc001bqe.2 uc001bqf.2 uc001bqg.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCC1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCC1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): RCC1 (NM_001048199) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RCC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCC1 |
Additional cDNA sequence: AF075052.1 AF498924.1 AJ006834.1 AJ006835.1 AK092726.1 AK311577.1 BC001589.1 BC006790.1 BC007300.1 BC010067.2 BC012122.1 BC017334.2 BC036903.1 BC065008.1 BC069198.1 CR407693.1 NR_002909.2 NR_030725.1 NR_030726.1 NR_036473.1 S75708.1 X06130.1 X12654.1 24 DOTS entries: DT.116202 DT.95327866 DT.97801136 DT.95327877 DT.100797105 DT.100797098 DT.100797106 DT.95327876 DT.100022007 DT.100742853 DT.91756238 DT.100022008 DT.86850191 DT.100797104 DT.97841265 DT.95256807 DT.100783018 DT.100797088 DT.100797103 DT.95327874 DT.95327880 DT.100783021 DT.121408192 DT.91706060 24/326 AceView cDNA sequences (see all 326): BC007300 AF498924 AL134800 NM_001269 BC065008 BC001589 BQ218931 AA977522 F10967 BF590413 BU624721 AJ006834 BX383560 AA313518 BE831173 BM555115 BM759606 BG764735 BM993043 BU539399 CR604404 AJ006835 AI921730 AA705507
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RCC1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | |
| ExUns: | 16b |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for RCC1
|
Expression
for RCC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RCC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTTGCTCA
About this image
See RCC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RCC1
SOURCE GeneReport for Unigene cluster: Hs.469723
SABiosciences Custom PCR Arrays for RCC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RCC1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RCC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCC1 |
Orthologs
for RCC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RCC1 gene from 9/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RCC11 |
regulator of chromosome condensation 1 |
75.38(n)
80.34(a) |
|
429810 XM_427366.3 XP_427366.3 |
lizard
(Anolis carolinensis) |
Reptilia |
RCC16 |
-- |
66(a) |
1 ↔ 1 |
GL343904.1(128858-134623) |
African clawed frog
(Xenopus laevis) |
Amphibia |
D00646.12 |
-- |
75.35(n) |
|
D00646.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC059796.12 |
-- |
76.36(n) |
|
BC059796.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Bj11 |
Bj1 protein |
50.51(n)
44.64(a) |
|
38669 NM_079219.3 NP_523943.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
ran-31 |
Protein RAN-3 |
44.44(n)
36.56(a) |
|
174332 NM_063352.3 NP_495753.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SRM1(YGL097W)4
SRM11 |
Nucleotide exchange factor for Gsp1p, localizes to more4
Srm1p1 |
42.69(n)1
33.33(a)1 |
|
7(321782-323230)4
8527821, 4 NP_011418.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G023006 |
regulator of chromosome condensation domain-contai... |
14(a) |
1 ↔ 1 |
3(461148-464174) |
rice
(Oryza sativa) |
Liliopsida |
-- |
Regulator of chromosome condensation domain contai... |
14(a) |
1 ↔ 1 |
3(22371413-22378682) |
ENSEMBL Gene Tree for RCC1 (if available)
TreeFam Gene Tree for RCC1 (if available) |
Paralogs
for RCC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RCC1 gene
- RCC22 RPGR2
3 SIMAP similar genes for RCC1 using alignment to 9 protein entries: RCC1_HUMAN (see all proteins):HERC6 HERC3 HERC4
RCC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RCC1
PGOHUM00000243201
|
Genomic Variants
for RCC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RCC1 (28832455 - 28865708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RCC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCC1 |
|
Disorders
/ Diseases
for RCC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RCC1 for disorders About GeneDecksing
OMIM gene information: 179710
OMIM disorders: --
9  diseases for RCC1: About MalaCardsattention deficit hyperactivity disorder retinitis pigmentosa herpes simplex lateral sclerosis
vaccinia retinitis retinoblastoma breast carcinoma
carcinoma
3 diseases from the University of Copenhagen DISEASES database for RCC1:Lateral sclerosis Retinitis pigmentosa Retinoblastoma Export disorders for RCC1 gene to outside databases
|
Publications
for RCC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RCC1 gene, integrated from 9 sources (see all 107):
(articles sorted by number of sources associating them with RCC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. (PubMed id 1944575)1, 2, 9 Bischoff F.R. and Ponstingl H. (1991)
- NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. (PubMed id 20668449)1, 2 Tooley C.E.... Macara I.G. (2010)
- Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1. (PubMed id 18762580)1, 2 Hao Y. and Macara I.G. (2008)
- N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. (PubMed id 17435751)1, 2 Chen T....Macara I.G. (2007)
- Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). (PubMed id 11336674)1, 2 Renault L....Wittinghofer A. (2001)
- The 1.7-A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. (PubMed id 9510255)1, 2 Renault L....Wittinghofer A. (1998)
- Mammalian cells have two functional RCC1 proteins produced by alternative splicing. (PubMed id 7983178)1, 2 Miyabashira J.... Nishimoto T. (1994)
|
External Searches for RCC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RCC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RCC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RCC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RCC1 gene:
Search GeneIP for patents involving RCC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RCC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for RCC1 | | OriGene shRNA RFP for RCC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RCC1 | | | OriGene Protein Over-expression Lysate for RCC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RCC1 | | OriGene 3'-UTR Clone for RCC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RCC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RCC1 | | OriGene Custom Protein Services for RCC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RCC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCC1 |
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| | Antibodies & Assays for RCC1 |
| | | | Search Tocris compounds for RCC1 |
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 | | | RCC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCC1 |
|  |  |  | | | | ThermoFisher Antibodies for RCC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCC1 |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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