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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RCBTB2 Gene

protein-coding GIFtS: 53
GCID: GC13M049063

regulator of chromosome condensation (RCC1) and BTB (POZ)...

(Previous name: chromosome condensation 1-like )
(Previous symbol: CHC1L)

Explore 3 diseases affiliated with
RCBTB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of Chromosome Condensation (RCC1) And BTB (POZ) Domain Containing Protein 2¹ ²		RCC1 And BTB Domain-Containing Protein 2²
CHC1L¹ ² ³ ⁵		RCC1-Like G Exchanging Factor RLG²
Chromosome Condensation 1-Like¹ ³		Regulator Of Chromosome Condensation And BTB Domain Containing Protein 2²
Regulator Of Chromosome Condensation And BTB Domain-Containing Protein 2² ³		RLG³
CHC1-L² ³		RCC1-Like G Exchanging Factor³

External Ids:	HGNC: 1914¹	Entrez Gene: 1102²	Ensembl: ENSG00000136161⁷	OMIM: 603524⁵	UniProtKB: O95199³

Export aliases for RCBTB2 gene to outside databases

Previous GC identifers: GC13M047962 GC13M029855

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCBTB2:

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows

similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF)

protein for the Ras-related GTPase Ran. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RCBTB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RCBTB2 gene promoter:
ER-alpha HFH-3 IRF-1 C/EBPalpha Evi-1 PPAR-alpha FOXI1 E2F-1 E2F ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RCBTB2 promoter sequence

Search SABiosciences Chromatin IP Primers for RCBTB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCBTB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.3

RCBTB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCBTB2 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M049063: view genomic region (about GC identifiers)

Start:	49,063,095 bp from pter	End:	49,107,369 bp from pter
Size:	44,275 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RCBT2_HUMAN, O95199 (See protein sequence)

Recommended Name: RCC1 and BTB domain-containing protein 2

Size: 551 amino acids; 60315 Da

Secondary accessions: B2RDW8

Alternative splicing: 2 isoforms: O95199-1 O95199-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RCBTB2: NX_O95199

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95199

RCBTB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001259.1

ENSEMBL proteins:

ENSP00000345144 ENSP00000389910 ENSP00000443862 ENSP00000443904

Human Recombinant Protein Products for RCBTB2:

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	Uscn ELISAs and CLIAs for RCBTB2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RCBTB2 for domains About GeneDecksing

5 InterPro domains/families:

IPR009091 Reg_csome_cond/b-lactamase_inh

IPR000210 BTB/POZ-like

IPR000408 Reg_chr_condens

IPR011333 BTB/POZ_fold

IPR013069 BTB_POZ

Graphical View of Domain Structure for InterPro Entry O95199

ProtoNet protein and cluster: O95199

UniProtKB/Swiss-Prot: RCBT2_HUMAN, O95199

Similarity: Contains 2 BTB (POZ) domains

Similarity: Contains 6 RCC1 repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005087	Ran guanyl-nucleotide exchange factor activity	TAS	9806834

RCBTB2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RCBTB2

miRNA Products:		OriGene 3'-UTR Clone: RCBTB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCBTB2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate RCBTB2 (see all 17):
		hsa-miR-2052 hsa-miR-3910 hsa-miR-320a hsa-miR-539 hsa-miR-124 hsa-miR-1909* hsa-miR-4330 hsa-miR-506

		SwitchGear 3'UTR luciferase reporter plasmid: RCBTB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCBTB2 (see all 7) OriGene shRNA RFP: RCBTB2 OriGene siRNA: RCBTB2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCBTB2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RCBTB2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for RCBTB2 (O95199^{2, 3} ENSP00000345144⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COPS4	Q9BT78²^,³, ENSP00000264389⁴	MINT-66264 I2D: score=5 STRING: ENSP00000264389
RCBTB2	O95199²	MINT-66788

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RCBTB2
Search CenterWatch for drugs/clinical trials and news about RCBTB2 / RCBT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RCBTB2 gene:

NM_001268.2

Unigene Cluster for RCBTB2:

Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2

Hs.652712 [show with all ESTs]

Unigene Representative Sequence: NM_001268

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000344532(uc001vch.3 uc010tgg.2 uc001vci.3 uc010tgh.2 uc001vcj.3 uc010acv.1 uc010tgi.1)

ENST00000462703 ENST00000481144 ENST00000430805 ENST00000544492 ENST00000544904

miRNA Products:		OriGene 3'-UTR Clone: RCBTB2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCBTB2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate RCBTB2 (see all 17):
		hsa-miR-2052 hsa-miR-3910 hsa-miR-320a hsa-miR-539 hsa-miR-124 hsa-miR-1909* hsa-miR-4330 hsa-miR-506

		SwitchGear 3'UTR luciferase reporter plasmid: RCBTB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against RCBTB2

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Additional cDNA sequence:

AB209543.1 AF060219.1 AK023010.1 AK122778.1 AK298438.1 AK301516.1 AK304598.1 AK310081.1

AK315703.1 BC029052.1

13 DOTS entries:

DT.412105 DT.91925401 DT.100812762 DT.95192607 DT.75197221 DT.102825131 DT.120769942 DT.120769954

DT.120863562 DT.91745519 DT.91810427 DT.91640424 DT.95252131

2 AceView cDNA sequences:

BC031965 BG772479

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for RCBTB2 (see all 17) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	^	12a	·	12b	^	13	^
SP1:															-		-										-		-		-		-
SP2:															-		-		-		-		-		-		-		-		-		-
SP3:																	-										-		-		-		-
SP4:																											-		-		-		-
SP5:															-		-				-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	14	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19a	·	19b	^	20a	·	20b	^	21	^	22a	·	22b	·	22c
SP1:							-								-				-		-		-
SP2:							-								-				-		-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RCBTB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RCBTB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATGTAAAG

About this image

RCBTB2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Epiblast-like cells (Reconstitution of mo...)

Primordial germ cell-like cells (Reconstitution of mo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RCBTB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RCBTB2

SOURCE GeneReport for Unigene cluster: Hs.652712

SABiosciences Custom PCR Arrays for RCBTB2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RCBTB2 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RCBTB2 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RCBTB2¹	regulator of chromosome condensation (RCC1) and BTB more	81.1(n) 87.16(a)		418861 XM_417055.3 XP_417055.2
lizard (Anolis carolinensis)	Reptilia	RCBTB2⁶	--	81(a)	1 ↔ 1	1(136839729-136863476)
African clawed frog (Xenopus laevis)	Amphibia	chc1l-A-prov²	chromosome condensation 1-like	76.66(n)		BC044119.1
zebrafish (Danio rerio)	Actinopterygii	rcbtb2¹	regulator of chromosome condensation (RCC1) and BTB more	69.96(n) 74.95(a)		794652 XM_001334622.4 XP_001334658.4
honey bee (Apis mellifera)	Insecta	-- --	--	44(a) 43(a)	many ↔ many many ↔ many	Group11.4(354-2686) Group11.4(4669-7022)

ENSEMBL Gene Tree for RCBTB2 (if available)
TreeFam Gene Tree for RCBTB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RCBTB2 gene

SERGEF² IBTK² WBSCR16² RCBTB1²

2 SIMAP similar genes for RCBTB2 using alignment to 4 protein entries: RCBT2_HUMAN (see all proteins):

RCBTB1 HERC4

RCBTB2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RCBTB2
PGOHUM00000238577

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9332035^1,2	C,F	--	29872058(-)	`GCATAA/CAGTAA`	1	--	ds500¹		5	NS NA WA	432
rs9332034^1,2	C,F,H	--	29872246(-)	`CTTCAG/AGTGCT`	1	--	ds500¹		6	NS EA NA	716
rs10076^1,2	C,F,O,H	--	29872836(+)	`AGTGAT/CCAATT`	1	--	ut3¹		25	NS MN NA EA WA	2868
rs9332032^1,2	C,F,H	--	29873117(-)	`GACCAT/CGTCGC`	1	--	ut3¹		18	NS EA NA WA	1952
rs77880565^1,2	F	--	29873250(+)	`AGGGGG/AAACAG`	1	--	ut3¹		1	WA	118
rs9332031^1,2	C,F,H	--	29873271(-)	`GAGAGG/TATTGC`	1	--	ut3¹		6	NS EA NA	684
rs9332030^1,2	C,F	--	29873399(-)	`TCCTCA/GGCTAA`	1	--	ut3¹		3	NS NA	166
rs9332029^1,2	C,H	--	29873450(-)	`TTATTT/GGCAAA`	1	--	ut3¹		5	NS EA	588
rs9332024^1,2	C,F,H	--	29874285(-)	`AGTAGG/ATCACT`	1	--	ut5¹		6	NS EA WA	698
rs9332023^1,2	C,F,H	--	29874302(-)	`TGTAGA/GAGTCT`	1	--	ut5¹		6	NS EA WA	698

HapMap Linkage Disequilibrium report for RCBTB2 (49063095 - 49107369 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RCBTB2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCBTB2

DNA2.0 Custom Variant and Variant Library Synthesis for RCBTB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RCBTB2 for disorders           About GeneDecksing

OMIM gene information: 603524    OMIM disorders: --

3 diseases for RCBTB2:    About MalaCards

williams-beuren syndrome prostate cancer prostatitis

Human Genome Epidemiology (HuGE) Navigator: RCBTB2 (2 documents)

Export disorders for RCBTB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RCBTB2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RCBTB2)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor. (PubMed id 9806834)^{1, 2, 3} Devilder M.-C.... Moisan J.-P. (1998)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The ubiquitin conjugating enzyme, UbcM2, engages in no vel interactions with components of cullin-3 based E3 ligases. (PubMed id 19256485)¹ Plafker K.S....Plafker S.M. (2009)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer. (PubMed id 12115502)¹ Latil A....Cussenot O. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation. (PubMed id 10089422)¹ Renault L....Vetter I.R. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

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Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1102	HGNC: 1914	AceView: CHC1L.1	Ensembl:ENSG00000136161	euGenes: HUgn1102
ECgene: RCBTB2	H-InvDB: RCBTB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RCBTB2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RCBTB2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/chc1l/

Intellectual Property for RCBTB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RCBTB2 gene:
Search GeneIP for patents involving RCBTB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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RCBTB2 Gene

regulator of chromosome condensation (RCC1) and BTB (POZ)...

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