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Aliases for RCBTB2 Gene

Aliases for RCBTB2 Gene

  • Regulator Of Chromosome Condensation (RCC1) And BTB (POZ) Domain Containing Protein 2 2 3
  • CHC1L 3 4 6
  • Chromosome Condensation 1-Like 2 4
  • RLG 3 4
  • Regulator Of Chromosome Condensation And BTB Domain-Containing Protein 2 4
  • RCC1 And BTB Domain-Containing Protein 2 3
  • RCC1-Like G Exchanging Factor RLG 3
  • RCC1-Like G Exchanging Factor 4
  • CHC1-L 4

External Ids for RCBTB2 Gene

Previous Symbols for RCBTB2 Gene

  • CHC1L

Summaries for RCBTB2 Gene

Entrez Gene Summary for RCBTB2 Gene

  • This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for RCBTB2 Gene

RCBTB2 (Regulator Of Chromosome Condensation (RCC1) And BTB (POZ) Domain Containing Protein 2) is a Protein Coding gene. GO annotations related to this gene include Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is RCC1.

Gene Wiki entry for RCBTB2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCBTB2 Gene

Genomics for RCBTB2 Gene

Genomic Location for RCBTB2 Gene

Start:
48,488,959 bp from pter
End:
48,533,256 bp from pter
Size:
44,298 bases
Orientation:
Minus strand

Genomic View for RCBTB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCBTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCBTB2 Gene

Regulatory Elements for RCBTB2 Gene

Proteins for RCBTB2 Gene

  • Protein details for RCBTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95199-RCBT2_HUMAN
    Recommended name:
    RCC1 and BTB domain-containing protein 2
    Protein Accession:
    O95199
    Secondary Accessions:
    • B2RDW8

    Protein attributes for RCBTB2 Gene

    Size:
    551 amino acids
    Molecular mass:
    60315 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RCBTB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCBTB2 Gene

Proteomics data for RCBTB2 Gene at MOPED

Post-translational modifications for RCBTB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCBTB2 Gene

No data available for DME Specific Peptides for RCBTB2 Gene

Domains for RCBTB2 Gene

Gene Families for RCBTB2 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for RCBTB2 Gene

UniProtKB/Swiss-Prot:

RCBT2_HUMAN
Domain:
  • Contains 2 BTB (POZ) domains.:
    • O95199
Similarity:
  • Contains 6 RCC1 repeats.:
    • O95199
genes like me logo Genes that share domains with RCBTB2: view

Function for RCBTB2 Gene

Gene Ontology (GO) - Molecular Function for RCBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005087 Ran guanyl-nucleotide exchange factor activity TAS 9806834
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RCBTB2: view

miRNA for RCBTB2 Gene

miRTarBase miRNAs that target RCBTB2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RCBTB2 Gene

Localization for RCBTB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCBTB2 Gene COMPARTMENTS Subcellular localization image for RCBTB2 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for RCBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle --
genes like me logo Genes that share ontologies with RCBTB2: view

Pathways for RCBTB2 Gene

SuperPathways for RCBTB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity TAS 9806834
genes like me logo Genes that share ontologies with RCBTB2: view

No data available for Pathways by source for RCBTB2 Gene

Transcripts for RCBTB2 Gene

mRNA/cDNA for RCBTB2 Gene

(9) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RCBTB2 Gene

Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCBTB2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - -
SP10: -
SP11: - - - - - - - -
SP12:
SP13: - - - - - - - - - - - - - - - -
SP14:
SP15:
SP16:
SP17:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
SP1: - - - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - -
SP17: -

Relevant External Links for RCBTB2 Gene

GeneLoc Exon Structure for
RCBTB2
ECgene alternative splicing isoforms for
RCBTB2

Expression for RCBTB2 Gene

mRNA expression in normal human tissues for RCBTB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RCBTB2 Gene

SOURCE GeneReport for Unigene cluster for RCBTB2 Gene Hs.652712

genes like me logo Genes that share expressions with RCBTB2: view

Orthologs for RCBTB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RCBTB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCBTB2 36
  • 94.73 (n)
  • 92.95 (a)
RCBTB2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RCBTB2 36
  • 90.45 (n)
  • 96.02 (a)
RCBTB2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCBTB2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcbtb2 36
  • 89.37 (n)
  • 96.02 (a)
Rcbtb2 16
Rcbtb2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RCBTB2 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCBTB2 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rcbtb2 36
  • 88.8 (n)
  • 95.64 (a)
chicken
(Gallus gallus)
Aves RCBTB2 36
  • 81.88 (n)
  • 88.4 (a)
RCBTB2 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCBTB2 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia chc1l-A-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rcbtb2 36
  • 73.83 (n)
  • 79.47 (a)
Str.15041 36
zebrafish
(Danio rerio)
Actinopterygii rcbtb2 36
  • 69.96 (n)
  • 74.95 (a)
rcbtb2 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ca 37
  • 6 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP25 39
SRM1 37
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9432 37
  • 48 (a)
OneToMany
Species with no ortholog for RCBTB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCBTB2 Gene

ENSEMBL:
Gene Tree for RCBTB2 (if available)
TreeFam:
Gene Tree for RCBTB2 (if available)

Paralogs for RCBTB2 Gene

Paralogs for RCBTB2 Gene

Selected SIMAP similar genes for RCBTB2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RCBTB2 Gene

genes like me logo Genes that share paralogs with RCBTB2: view

Variants for RCBTB2 Gene

Sequence variations from dbSNP and Humsavar for RCBTB2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs10076 -- 48,505,367(+) AGTGA(C/T)CAATT intron-variant
rs11861 -- 48,505,141(+) TAGCA(C/G)TAGGC intron-variant
rs751334 -- 48,506,228(+) GGGAC(A/G)GAGGC intron-variant
rs752663 -- 48,534,833(+) ATTTA(G/T)ACTCT upstream-variant-2KB
rs877938 -- 48,512,678(-) TATGT(A/T)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCBTB2 Gene

Variant ID Type Subtype PubMed ID
nsv832602 CNV Loss 17160897
nsv832604 CNV Loss 17160897
esv2520493 CNV Deletion 19546169
esv269860 CNV Insertion 20981092

Relevant External Links for RCBTB2 Gene

HapMap Linkage Disequilibrium report
RCBTB2

Disorders for RCBTB2 Gene

Relevant External Links for RCBTB2

Genetic Association Database (GAD)
RCBTB2
Human Genome Epidemiology (HuGE) Navigator
RCBTB2
genes like me logo Genes that share disorders with RCBTB2: view

No data available for UniProtKB/Swiss-Prot for RCBTB2 Gene

Publications for RCBTB2 Gene

  1. cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor. (PMID: 9806834) Devilder M.-C. … Moisan J.-P. (Genomics 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for RCBTB2 Gene

Sources for RCBTB2 Gene

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