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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCBTB2 Gene

protein-coding   GIFtS: 54
GCID: GC13M049063

Regulator Of Chromosome Condensation (RCC1) And BTB (POZ)...

(Previous name: chromosome condensation 1-like)
(Previous symbol: CHC1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of Chromosome Condensation (RCC1) And BTB (POZ) Domain
Containing Protein 21 2
     RCC1 And BTB Domain-Containing Protein 22
CHC1L1 2 3 5     RCC1-Like G Exchanging Factor RLG2
Chromosome Condensation 1-Like1 3     Regulator Of Chromosome Condensation And BTB Domain Containing Protein 22
Regulator Of Chromosome Condensation And BTB Domain-Containing Protein 22 3     RLG3
CHC1-L2 3     RCC1-Like G Exchanging Factor3

External Ids:    HGNC: 19141   Entrez Gene: 11022   Ensembl: ENSG000001361617   OMIM: 6035245   UniProtKB: O951993   

Export aliases for RCBTB2 gene to outside databases

Previous GC identifers: GC13M047962 GC13M029855


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCBTB2 Gene:
This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence
shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange
factor (GEF) protein for the Ras-related GTPase Ran. (provided by RefSeq, Jul 2008)

GeneCards Summary for RCBTB2 Gene: 
RCBTB2 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2) is a protein-coding gene. Diseases associated with RCBTB2 include williams-beuren syndrome, and prostate cancer. GO annotations related to this gene include Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is SERGEF.

Gene Wiki entry for RCBTB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCBTB2 gene promoter:
         ER-alpha   HFH-3   IRF-1   C/EBPalpha   Evi-1   PPAR-alpha   FOXI1   E2F-1   E2F   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCBTB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCBTB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCBTB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.3

RCBTB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCBTB2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M049063:  view genomic region     (about GC identifiers)

Start:
49,063,095 bp from pter      End:
49,107,369 bp from pter
Size:
44,275 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RCBT2_HUMAN, O95199 (See protein sequence)
Recommended Name: RCC1 and BTB domain-containing protein 2  
Size: 551 amino acids; 60315 Da
Secondary accessions: B2RDW8
Alternative splicing: 2 isoforms:  O95199-1   O95199-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RCBTB2: NX_O95199

Explore proteomics data for RCBTB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95199

  • RCBTB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCBTB2 Protein Expression
    REFSEQ proteins: NP_001259.1  
    ENSEMBL proteins: 
     ENSP00000345144   ENSP00000389910   ENSP00000443862   ENSP00000443904  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing

    5 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR000210 BTB/POZ-like
     IPR000408 Reg_chr_condens
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O95199

    ProtoNet protein and cluster: O95199

    UniProtKB/Swiss-Prot: RCBT2_HUMAN, O95199
    Similarity: Contains 2 BTB (POZ) domains
    Similarity: Contains 6 RCC1 repeats


    RCBTB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005087Ran guanyl-nucleotide exchange factor activity TAS9806834
    GO:0005515protein binding ----
         
    RCBTB2 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRCBTB2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCBTB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCBTB2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for RCBTB2 (O951992, 3 ENSP000003451444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS4Q9BT782, 3, ENSP000002643894MINT-66264 I2D: score=5 STRING: ENSP00000264389
    RCBTB2O951992MINT-66788
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCBTB2 (RCBT2)

    Search CenterWatch for drugs/clinical trials and news about RCBTB2 / RCBT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCBTB2 gene: 
    NM_001268.2  

    Unigene Cluster for RCBTB2:

    Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
    Hs.652712  [show with all ESTs]
    Unigene Representative Sequence: NM_001268
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344532(uc001vch.3 uc010tgg.2 uc001vci.3 uc010tgh.2 uc001vcj.3 uc010acv.1 uc010tgi.1)
    ENST00000462703 ENST00000481144 ENST00000430805 ENST00000544492 ENST00000544904

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRCBTB2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCBTB2
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    Additional mRNA sequence: 

    AB209543.1 AF060219.1 AK023010.1 AK122778.1 AK298438.1 AK301516.1 AK304598.1 AK310081.1 
    AK315703.1 BC029052.1 

    13 DOTS entries:

    DT.412105  DT.91925401  DT.100812762  DT.95192607  DT.75197221  DT.102825131  DT.120769942  DT.120769954 
    DT.120863562  DT.91745519  DT.91810427  DT.91640424  DT.95252131 

    2 AceView cDNA sequences:

    BC031965 BG772479 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for RCBTB2 (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^
    SP1:                                            -     -                             -     -     -     -                                                         
    SP2:                                            -     -     -     -     -     -     -     -     -     -                                                         
    SP3:                                                  -                             -     -     -     -                                                         
    SP4:                                                                                -     -     -     -                                                         
    SP5:                                            -     -           -     -     -     -     -     -     -     -     -     -     -     -     -     -               

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
    SP1:                    -                       -           -     -     -                     
    SP2:                    -                       -           -     -     -                     
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RCBTB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCBTB2 expression in normal human tissues (normalized intensities)      RCBTB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGTAAAG
    RCBTB2 Expression
    About this image


    RCBTB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule

    See RCBTB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCBTB2

    SOURCE GeneReport for Unigene cluster: Hs.652712
        SABiosciences Custom PCR Arrays for RCBTB2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCBTB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RCBTB2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcbtb21 , 5 regulator of chromosome condensation (RCC1) and BTB more1, 5 89.29(n)1
    95.28(a)1
      14 (38.66 cM)5
    1056701  NM_001170694.11  NP_001164165.11 
     731230375 
    chicken
    (Gallus gallus)
    Aves RCBTB21 regulator of chromosome condensation (RCC1) and BTB more 81.1(n)
    87.16(a)
      418861  XM_417055.3  XP_417055.2 
    lizard
    (Anolis carolinensis)
    Reptilia RCBTB26
    Uncharacterized protein
    81(a)
    1 ↔ 1
    1(136839729-136863476)
    African clawed frog
    (Xenopus laevis)
    Amphibia chc1l-A-prov2 chromosome condensation 1-like 76.66(n)    BC044119.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rcbtb21 regulator of chromosome condensation (RCC1) and BTB more 69.96(n)
    74.95(a)
      794652  XM_001334622.4  XP_001334658.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74206
    --
    20(a)
    1 → many
    2L(1500835-1502903)


    ENSEMBL Gene Tree for RCBTB2 (if available)
    TreeFam Gene Tree for RCBTB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCBTB2 gene
    SERGEF2  RCC22  IBTK2  WBSCR162  RCC12  RPGR2  RCBTB12  
    2 SIMAP similar genes for RCBTB2 using alignment to 4 protein entries:     RCBT2_HUMAN (see all proteins):
    RCBTB1    HERC4

    RCBTB2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RCBTB2
    PGOHUM00000238577


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/943 SNPs in RCBTB2 are shown (see all 943)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875881711,2
    --49062624(+) TCATTA/TTACAT 1 -- ds50010--------
    rs1497116591,2
    --49062753(+) TGGGGA/GGTGTT 1 -- ds50010--------
    rs1911554431,2
    --49062776(+) GGCTGC/TGCATG 1 -- ds50010--------
    rs93320871,2
    C,F,H--49062872(-) GGTGAC/TTtttt 1 -- ds50016Minor allele frequency- T:0.01NS EA WA 716
    rs93320861,2
    C,F,H--49062888(-) TGCTCT/CTTATT 1 -- ds500110Minor allele frequency- C:0.08NS EA NA CSA WA 860
    rs9770971,2
    H--49062947(-) CCCTAG/CACCAC 1 -- ds50014Minor allele frequency- C:0.00NS EA 416
    rs93320851,2
    C,F,H--49062990(-) CTTATC/TAAGCA 1 -- ds500115Minor allele frequency- T:0.04NS EA NA WA 1828
    rs93320841,2
    C,F--49063156(-) TTAGAA/GTTCTT 1 -- ut316Minor allele frequency- G:0.01NS NA 324
    rs93320831,2
    H--49063260(-) CAAATT/AACCTA 1 -- ut31 ese35Minor allele frequency- A:0.00NS EA 596
    rs1877700181,2
    --49063270(+) GTTTTA/GATCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RCBTB2 (49063095 - 49107369 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RCBTB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2520493CNV Deletion19546169
    esv269860CNV Insertion20981092
    nsv832604CNV Loss17160897
    nsv832602CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603524    OMIM disorders: --

    3 diseases for RCBTB2:    About MalaCards
    williams-beuren syndrome    prostate cancer    prostatitis


    RCBTB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RCBTB2
    Human Genome Epidemiology (HuGE) Navigator: RCBTB2 (2 documents)

    Export disorders for RCBTB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCBTB2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RCBTB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor. (PubMed id 9806834)1, 2, 3 Devilder M.-C.... Moisan J.-P. (1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. The ubiquitin conjugating enzyme, UbcM2, engages in no vel interactions with components of cullin-3 based E3 ligases. (PubMed id 19256485)1 Plafker K.S....Plafker S.M. (2009)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer. (PubMed id 12115502)1 Latil A....Cussenot O. (2002)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1102 HGNC: 1914 AceView: CHC1L.1 Ensembl:ENSG00000136161 euGenes: HUgn1102
    ECgene: RCBTB2 H-InvDB: RCBTB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCBTB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCBTB2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/chc1l/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCBTB2 gene:
    Search GeneIP for patents involving RCBTB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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