RCBTB1 Gene
protein-coding GIFtS: 50
GCID: GC13M050106
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|
regulator of chromosome condensation (RCC1) and BTB (POZ)...
| |
Aliases
for RCBTB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regulator Of Chromosome Condensation (RCC1) And BTB (POZ) Domain ContainingProtein 11 2 | | GLP2 5 | | CLLD71 2 3 5 | | FLJ107161 | | CLLL71 2 | | RP11-185C18.12 | | Chronic Lymphocytic Leukemia Deletion Region Gene 7 Protein2 3 | | GDP/GTP Exchange Factor (GEF)-Like Protein2 | | Regulator Of Chromosome Condensation And BTB Domain-Containing Protein 12 3 | | RCC1 And BTB Domain-Containing Protein 12 | | CLL Deletion Region Gene 7 Protein2 3 | | E4.53 |
Export aliases for RCBTB1 gene to outside databasesPrevious GC identifers: GC13M049042 GC13M047904 GC13M049004 GC13M030899 |
Summaries
for RCBTB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RCBTB1:
This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack andbric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellularhypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene mapsto a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoidmalignancies. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RCBT1_HUMAN, Q8NDN9Function: May be involved in cell cycle regulation by chromatin remodeling
Gene Wiki entry for RCBTB1
|
Genomic Views
for RCBTB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RCBTB1 gene promoter:
c-Fos AP-1 JunB Fra-1 FosB NF-AT4 JunD NF-AT2 NF-AT3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for RCBTB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCBTB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14RCBTB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M050106: view genomic region
(about GC identifiers)
Start:
|
50,106,082 bp from pter |
End:
|
50,159,719 bp from pter |
Size:
|
53,638 bases |
Orientation:
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minus strand |
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Proteins
for RCBTB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RCBT1_HUMAN, Q8NDN9 (See
protein sequence)Recommended Name: RCC1 and BTB domain-containing protein 1 Size: 531 amino acids; 58252 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q8IY29 Q969U9Alternative splicing: 2 isoforms: Q8NDN9-1 Q8NDN9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RCBTB1: NX_Q8NDN9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NDN9
RCBTB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060661.3
ENSEMBL proteins: ENSP00000367552 ENSP00000258646 ENSP00000443293
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RCBTB1 for ontologies About GeneDecksing
RCBTB1 Antibody Products:
Assay Products for RCBTB1: |
Protein
Domains /
Families
for RCBTB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RCBTB1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NDN9ProtoNet protein and cluster: Q8NDN9 UniProtKB/Swiss-Prot: RCBT1_HUMAN, Q8NDN9Similarity: Contains 2 BTB (POZ) domainsSimilarity: Contains 6 RCC1 repeats |
Function
for RCBTB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RCBT1_HUMAN, Q8NDN9Function: May be involved in cell cycle regulation by chromatin remodeling
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCBTB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCBTB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCBTB1 |
2 GenomeRNAi human phenotypes for RCBTB1:
|
Pathways & Interactions
for RCBTB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCBTB1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/14 Interacting proteins for RCBTB1 (Q8NDN92, 3 ENSP000002586464) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007049 | cell cycle |
IEA | -- | | GO:0016568 | chromatin modification |
IEA | -- |
RCBTB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RCBTB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RCBTB1
Search CenterWatch for drugs/clinical trials and news about RCBTB1 / RCBT1
|
Transcripts
for RCBTB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RCBTB1 gene: NM_018191.3 Unigene Cluster for RCBTB1: Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 Hs.508021 [show with all ESTs]Unigene Representative Sequence: AB2092225 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378302(uc001vde.1) ENST00000471984 ENST00000490058 ENST00000258646
ENST00000546015
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCBTB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCBTB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RCBTB1 (NM_018191) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RCBTB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCBTB1 |
Additional cDNA sequence: AB209222.1 AF334406.1 AJ319660.1 AK001578.1 AK090807.1 AK096654.1 AL833821.1 BC038104.2 14 DOTS entries: DT.415901 DT.91892468 DT.120778527 DT.40286863 DT.100710039 DT.102830072 DT.120778531 DT.91647217 DT.92422950 DT.102830073 DT.209705 DT.40131543 DT.91965211 DT.100643675 24/175 AceView cDNA sequences (see all 175): AA496843 AI968206 AA418095 AI089527 AA228664 AA725338 CD643110 BM727256 AV759431 AI634732 AA459630 BU628875 BP375936 BF195846 AI805876 AA489719 AU124248 H24667 AA459405 AX746625 H21608 AK090807 BE045495 AI911279
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RCBTB1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | - | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RCBTB1
|
Expression
for RCBTB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RCBTB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAATAAACA
About this image
See RCBTB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RCBTB1
SOURCE GeneReport for Unigene cluster: Hs.508021
UniProtKB/Swiss-Prot: RCBT1_HUMAN, Q8NDN9Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for RCBTB1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RCBTB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RCBTB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCBTB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCBTB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCBTB1 |
Orthologs
for RCBTB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RCBTB1 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for RCBTB1 (if available)
TreeFam Gene Tree for RCBTB1 (if available) |
Paralogs
for RCBTB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RCBTB1 gene
- SERGEF2 RCBTB22 IBTK2 WBSCR162
1 SIMAP similar gene for RCBTB1 using alignment to 1 protein entry: RCBT1_HUMAN:RCBTB2
RCBTB1 for paralogs About GeneDecksing
|
Genomic Variants
for RCBTB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RCBTB1 (50106082 - 50159719 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RCBTB1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCBTB1 |
|
Disorders
/ Diseases
for RCBTB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RCBTB1 for disorders About GeneDecksing
OMIM gene information: 607867
OMIM disorders: 103780
7  diseases for RCBTB1: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia beta-glycopyranoside tasting leukemia
alcohol dependence alcoholism asthma
Human Genome Epidemiology (HuGE) Navigator: RCBTB1 (2 documents)
Export disorders for RCBTB1 gene to outside databases
|
Publications
for RCBTB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RCBTB1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with RCBTB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia. (PubMed id 11306461)1, 2, 3, 9 Mabuchi H.... Croce C.M. (2001)
- 13q deletion in chronic lymphocytic leukemia: characterization of E4.5, a novel chromosome condensation regulator-like guanine nucleotide exchange factor. (PubMed id 14565662)1, 2, 9 Solomou E.E.... Panayiotidis P. (2003)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Clld7, a candidate tumor suppressor on chromosome 13q 14, regulates pathways of DNA damage/repair and apoptosis. (PubMed id 20926398)1 Zhou X. and MA1nger K. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- A multi-centre study of candidate genes for wheeze an d allergy: the International Study of Asthma and Allergies in Childhood Phase 2 . (PubMed id 20085599)1 Genuneit J....Moffatt M.F. (2009)
- The ubiquitin conjugating enzyme, UbcM2, engages in no vel interactions with components of cullin-3 based E3 ligases. (PubMed id 19256485)1 Plafker K.S....Plafker S.M. (2009)
|
External Searches for RCBTB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RCBTB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RCBTB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RCBTB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RCBTB1 gene:
Search GeneIP for patents involving RCBTB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RCBTB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RCBTB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCBTB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCBTB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCBTB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCBTB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCBTB1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCBTB1 |
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