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RCAN3 Gene

protein-coding   GIFtS: 57
GCID: GC01P024829

RCAN Family Member 3

(Previous name: Down syndrome critical region gene 1-like 2)
(Previous symbol: DSCR1L2)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RCAN Family Member 31 2     RCN32
DSCR1L21 2 3 5     calcipressin-32
MCIP32 3 5     Down Syndrome Candidate Region 1-Like 22
Down Syndrome Critical Region Gene 1-Like 21 2     hRCN32
Down Syndrome Candidate Region 1-Like Protein 22 3     Regulator Of Calcineurin 3 Isoform 1b,22
Myocyte-Enriched Calcineurin-Interacting Protein 32 3     Regulator Of Calcineurin 33

External Ids:    HGNC: 30421   Entrez Gene: 111232   Ensembl: ENSG000001176027   OMIM: 6058605   UniProtKB: Q9UKA83   

Export aliases for RCAN3 gene to outside databases

Previous GC identifers: GC01P024702 GC01P023084


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RCAN3 Gene:
RCAN3 (RCAN family member 3) is a protein-coding gene. Diseases associated with RCAN3 include down syndrome, and endometrial adenocarcinoma. GO annotations related to this gene include RNA binding and troponin I binding. An important paralog of this gene is RCAN2.

UniProtKB/Swiss-Prot: RCAN3_HUMAN, Q9UKA8
Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of
calcineurin A. Could play a role during central nervous system development (By similarity)

Gene Wiki entry for RCAN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RCAN3 gene promoter:
         MEF-2A   RFX1   HSF2   Brachyury   HSF1short   HSF1 (long)   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCAN3 promoter sequence
   Search Chromatin IP Primers for RCAN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RCAN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3-p33   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3-p33

RCAN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCAN3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024829:  view genomic region     (about GC identifiers)

Start:
24,829,387 bp from pter      End:
24,867,530 bp from pter
Size:
38,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RCAN3_HUMAN, Q9UKA8 (See protein sequence)
Recommended Name: Calcipressin-3  
Size: 241 amino acids; 27492 Da
Secondary accessions: A4GU14 A4LA69 E7ENV1 E7EWD8 Q5ECL3 Q5TGC6 Q9NUC8 Q9UKA7
Alternative splicing: 5 isoforms:  Q9UKA8-1   Q9UKA8-2   Q9UKA8-3   Q9UKA8-4   Q9UKA8-5   (Ref.2 (AAW83514) sequence is in conflict in position: 106:R->Q)

Explore the universe of human proteins at neXtProt for RCAN3: NX_Q9UKA8

Explore proteomics data for RCAN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RCAN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001238906.1  NP_001238907.1  NP_001238908.1  NP_001238909.1  NP_001238910.1  NP_001238911.1  NP_001238912.1  NP_001238913.1  
    NP_001238914.1  NP_038469.1  

    ENSEMBL proteins: 
     ENSP00000363516   ENSP00000409540   ENSP00000437338   ENSP00000414447   ENSP00000445401  
     ENSP00000391912   ENSP00000363514  

    RCAN3 Human Recombinant Protein Products:

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    Novus Biologicals RCAN3 Proteins
    Novus Biologicals RCAN3 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RCAN3
    Cloud-Clone Corp. Proteins for RCAN3

    RCAN3 Antibody Products:

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    RCAN3 Assay Products:

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    Cloud-Clone Corp. ELISAs for RCAN3
    Cloud-Clone Corp. CLIAs for RCAN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006931 Calcipressin

    Graphical View of Domain Structure for InterPro Entry Q9UKA8

    ProtoNet protein and cluster: Q9UKA8

    1 Blocks protein domain: IPB006931 Calcipressin

    UniProtKB/Swiss-Prot: RCAN3_HUMAN, Q9UKA8
    Similarity: Belongs to the RCAN family


    RCAN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCAN3_HUMAN, Q9UKA8
    Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of
    calcineurin A. Could play a role during central nervous system development (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS10756093
    GO:0031013troponin I binding IPI16516408
         
    RCAN3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RCAN3:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RCAN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RCAN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCAN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCAN3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RCAN3:
    hsa-mir-92a-3p (MIRT049606)

    Block miRNA regulation of human, mouse, rat RCAN3 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RCAN3:
    hsa-miR-182 hsa-miR-1271 hsa-miR-96 hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidRCAN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RCAN3
    Predesigned siRNA for gene silencing in human, mouse, rat RCAN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RCAN3

    Clone
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    OriGene clones in human, mouse for RCAN3 (see all 7)
    OriGene ORF clones in mouse, rat for RCAN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RCAN3 (NM_013441)
    Sino Biological Human cDNA Clone for RCAN3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCAN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCAN3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RCAN3
    Browse ESI BIO Cell Lines and PureStem Progenitors for RCAN3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RCAN3
        NFAT and Cardiac Hypertrophy
    NFAT in Immune Response



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RCAN3
    Interactions:

        Search GeneGlobe Interaction Network for RCAN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for RCAN3 (Q9UKA83 ENSP000003635164) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNI3P194293, ENSP000003418384I2D: score=1 STRING: ENSP00000341838
    PPP3R2ENSP000003639394STRING: ENSP00000363939
    BYSLENSP000002303404STRING: ENSP00000230340
    CHP1ENSP000003356324STRING: ENSP00000335632
    CHP2ENSP000003001134STRING: ENSP00000300113
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009653anatomical structure morphogenesis TAS10756093
    GO:0019722calcium-mediated signaling IEA--

    RCAN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RCAN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RCAN3 gene (10 alternative transcripts): 
    NM_001251977.1  NM_001251978.1  NM_001251979.1  NM_001251980.1  NM_001251981.1  NM_001251982.1  NM_001251983.1  NM_001251984.1  
    NM_001251985.1  NM_013441.3  

    Unigene Cluster for RCAN3:

    RCAN family member 3
    Hs.656799  [show with all ESTs]
    Unigene Representative Sequence: BC035854
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374395(uc021ojc.1 uc021ojd.1 uc021oje.1 uc001bjj.3 uc009vre.3 uc021ojf.1 uc021ojg.1 uc009vrg.3 uc009vrd.3 uc009vrf.3)
    ENST00000425530 ENST00000482807 ENST00000436717 ENST00000538532 ENST00000412742
    ENST00000374393

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RCAN3 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RCAN3:
    hsa-miR-182 hsa-miR-1271 hsa-miR-96 hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidRCAN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RCAN3
    Predesigned siRNA for gene silencing in human, mouse, rat RCAN3
    Clone
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    OriGene clones in human, mouse for RCAN3 (see all 7)
    OriGene ORF clones in mouse, rat for RCAN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RCAN3 (NM_013441)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCAN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCAN3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RCAN3
    OriGene qSTAR qPCR primer pairs in human, mouse for RCAN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RCAN3
      QuantiTect SYBR Green Assays in human, mouse, rat RCAN3
      QuantiFast Probe-based Assays in human, mouse, rat RCAN3

    Additional mRNA sequence: 

    AF176116.1 AF176117.1 AY906854.1 BC035854.1 EF431960.1 EF467309.1 EF529733.1 GQ411200.1 
    HQ287726.1 HQ317421.1 HQ317422.1 HQ317423.1 HQ317426.1 HQ317427.1 JN203053.1 JN228252.1 

    4 DOTS entries:

    DT.307652  DT.100020374  DT.121334845  DT.97821245 

    Selected AceView cDNA sequences (see all 159):

    AA101783 BM310832 N36617 AF086431 BQ897870 BQ775389 H97812 BU786167 
    AI090634 NM_013441 AI160949 W79122 AI632890 AA886756 BE670753 BQ894646 
    BM843275 BU947377 BU157485 AA258370 BF590991 CB049741 BI712498 BE503561 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RCAN3 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b
    SP1:                                -                                                                                 
    SP2:                                                              -                                                   
    SP3:        -     -     -     -     -                                                                                 
    SP4:                          -     -                       -                                                         
    SP5:                          -     -                                                                                 


    ECgene alternative splicing isoforms for RCAN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RCAN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTGTGGT
    RCAN3 Expression
    About this image


    RCAN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Brain (Nervous System)
             Hypothalamus
    RCAN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RCAN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656799

    UniProtKB/Swiss-Prot: RCAN3_HUMAN, Q9UKA8
    Tissue specificity: Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes.
    Lower expression in all other tissues

        Custom PCR Arrays for RCAN3
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    QuantiFast Probe-based Assays in human, mouse, rat RCAN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RCAN3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcan31 , 5 regulator of calcineurin 31, 5 80.89(n)1
    90.38(a)1
      4 (67.59 cM)5
    539021  NM_022980.41  NP_075356.11 
     1354123085 
    chicken
    (Gallus gallus)
    Aves RCAN31 RCAN family member 3 79.53(n)
    87.97(a)
      419698  NM_001030907.1  NP_001026078.1 
    lizard
    (Anolis carolinensis)
    Reptilia RCAN36
    RCAN family member 3
    82(a)
    1 ↔ 1
    GL343464.1(180853-185818)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rcan31 RCAN family member 3 76.62(n)
    82.68(a)
      100124707  NM_001102693.1  NP_001096163.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rcan31 regulator of calcineurin family member 3 68.41(n)
    76.52(a)
      325356  NM_001005392.1  NP_001005392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sra6
    sarah
    25(a)
    1 → many
    3R(12012656-12023315)
    worm
    (Caenorhabditis elegans)
    Secernentea rcn-11 rcn-1 55.63(n)
    46.1(a)
      175788  NM_065822.5  NP_498223.2 


    ENSEMBL Gene Tree for RCAN3 (if available)
    TreeFam Gene Tree for RCAN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RCAN3 gene
    RCAN22  RCAN12  
    3 SIMAP similar genes for RCAN3 using alignment to 9 protein entries:     RCAN3_HUMAN (see all proteins):
    RCAN2    DSCR1    RCAN1

    RCAN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RCAN3 (see all 722)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770152391,2
    C,F--24830918(+) CTCCCG/AAAGTG 6 -- int11Minor allele frequency- A:0.50WA 2
    rs346364191,2
    C,F--24830950(+) ACCGCA/TCCCAG 6 -- int14Minor allele frequency- T:0.25NA WA 8
    rs114381731,2
    C--24830955(+) CCCAGC/-CCAAA 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs112491271,2
    C,F--24831034(+) AAATAT/CAACGT 6 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs75466441,2
    C--24831081(+) GACAAA/GAGCAG 6 -- int10--------
    rs1460089361,2
    C--24831100(+) TGGTGA/TTAGAG 6 -- int10--------
    rs1907739621,2
    --24831112(+) TGTTGA/GTTGAA 6 -- int10--------
    rs1808275841,2
    --24831121(+) AAGGAC/TTTAAA 6 -- int10--------
    rs740603791,2
    C,F--24831304(+) TATACA/GCAGCA 6 -- int12Minor allele frequency- G:0.04WA 120
    rs1862788031,2
    --24831342(+) TCAACC/TTCAGT 6 -- int10--------

    HapMap Linkage Disequilibrium report for RCAN3 (24829387 - 24867530 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RCAN3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RCAN3
    DNA2.0 Custom Variant and Variant Library Synthesis for RCAN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605860    OMIM disorders: --

    6 diseases for RCAN3:    
    About MalaCards
    down syndrome    endometrial adenocarcinoma    chronic lymphocytic leukemia    adenocarcinoma
    leukemia    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for RCAN3:
    Down syndrome

    RCAN3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for RCAN3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 67.6 4 16516408 (2), 10756093 (1), 11080588 (1)

    Genetic Association Database (GAD): RCAN3
    Human Genome Epidemiology (HuGE) Navigator: RCAN3 (1 document)

    Export disorders for RCAN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RCAN3 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with RCAN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). (PubMed id 10756093)1, 2, 3, 9 Strippoli P.... Zannotti M. (Genomics 2000)
    2. Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3). (PubMed id 16516408)1, 2, 9 Canaider S.... Strippoli P. (Gene 2006)
    3. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    4. Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms. (PubMed id 18022329)1, 2 Facchin F.... Strippoli P. (Gene 2008)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Complexity of Bidirectional Transcription and Alternative Splicing at Human RCAN3 Locus. (PubMed id 21961037)1 Facchin F.... Canaider S. (PLoS ONE 2011)
    9. Human RCAN3 gene expression and cell growth in endothelial cells. (PubMed id 21042787)1 Canaider S....Perretti M. (Int. J. Mol. Med. 2010)
    10. Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway. (PubMed id 19819266)1 Sales K.J....Jabbour H.N. (Biochim. Biophys. Acta 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11123 HGNC: 3042 AceView: DSCR1L2 Ensembl:ENSG00000117602 euGenes: HUgn11123
    ECgene: RCAN3 H-InvDB: RCAN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RCAN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RCAN3 gene:
    Search GeneIP for patents involving RCAN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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