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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCAN2 Gene

protein-coding   GIFtS: 57
GCID: GC06M046188

Regulator Of Calcineurin 2

(Previous name: Down syndrome critical region gene 1-like 1)
(Previous symbol: DSCR1L1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of Calcineurin 21 2 3     Down Syndrome Candidate Region 1-Like 12 3
DSCR1L11 2 3 5     CSP22 5
MCIP22 3 5     RCN22
ZAKI42 3 5     ZAKI-42
Down Syndrome Critical Region Gene 1-Like 11 2     calcipressin-22
Myocyte-Enriched Calcineurin-Interacting Protein 22 3     Thyroid Hormone-Responsive (Skin Fibroblasts)2
Thyroid Hormone-Responsive Protein ZAKI-42 3     

External Ids:    HGNC: 30411   Entrez Gene: 102312   Ensembl: ENSG000001723487   OMIM: 6048765   UniProtKB: Q142063   

Export aliases for RCAN2 gene to outside databases

Previous GC identifers: GC06M046297 GC06M045911


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCAN2 Gene:
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in
many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated
nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is
upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and
angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for RCAN2 Gene: 
RCAN2 (regulator of calcineurin 2) is a protein-coding gene. Diseases associated with RCAN2 include down syndrome, and down syndrome critical region, and among its related super-pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include nucleotide binding and protein phosphatase 2B binding. An important paralog of this gene is RCAN1.

UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206
Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of
calcineurin A. Could play a role during central nervous system development

Gene Wiki entry for RCAN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCAN2 gene promoter:
         AML1a   Evi-1   YY1   NF-AT   NF-AT4   POU2F1   NF-AT2   POU2F1b   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCAN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCAN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCAN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

RCAN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCAN2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M046188:  view genomic region     (about GC identifiers)

Start:
46,188,469 bp from pter      End:
46,459,709 bp from pter
Size:
271,241 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206 (See protein sequence)
Recommended Name: Calcipressin-2  
Size: 197 amino acids; 21997 Da
Sequence caution: Sequence=BAA11911.1; Type=Erroneous initiation;
Secondary accessions: A6ND07 B3KR46 Q5VWF7 Q5VWF8 Q8N116
Alternative splicing: 2 isoforms:  Q14206-1   Q14206-2   

Explore the universe of human proteins at neXtProt for RCAN2: NX_Q14206

Explore proteomics data for RCAN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14206

  • RCAN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCAN2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001238902.1  NP_001238903.1  NP_005813.2  

    ENSEMBL proteins: 
     ENSP00000329454   ENSP00000360425   ENSP00000305223   ENSP00000384317  

    Human Recombinant Protein Products for RCAN2: 
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    OriGene Protein Over-expression Lysate for RCAN2
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    Novus Biologicals RCAN2 Proteins
    Novus Biologicals RCAN2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RCAN2
    Cloud-Clone Corp. Proteins for RCAN2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    RCAN2 for ontologies           About GeneDecksing



    RCAN2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for RCAN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006931 Calcipressin
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q14206

    ProtoNet protein and cluster: Q14206

    1 Blocks protein domain: IPB006931 Calcipressin

    UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206
    Similarity: Belongs to the RCAN family


    RCAN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCAN2_HUMAN, Q14206
    Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of
    calcineurin A. Could play a role during central nervous system development
    Induction: By thyroid hormone

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0030346protein phosphatase 2B binding NAS--
         
    RCAN2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RCAN2:
     Decreased viability with carbo  Decreased viability with pacli  Increased G1 DNA content  Synthetic lethal with imatinib 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rcan2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system 
     skeleton 

    RCAN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rcan2tm1Jmol for RCAN2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCAN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCAN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCAN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCAN2 

    miRNA
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    miRTarBase miRNAs that target RCAN2:
    hsa-mir-155 (MIRT001507)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCAN2
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate RCAN2 (see all 50):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-371-5p hsa-miR-9 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidRCAN2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCAN2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RCAN2

    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCAN2
    Sirion Biotech Customized lentivirus for stable overexpression of RCAN2 
                         Customized lentivirus expression plasmids for stable overexpression of RCAN2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RCAN2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium signaling in the CD4+ TCR pathway
    Calcium signaling in the CD4+ TCR pathway0.38
    2Role of Calcineurin-dependent NFAT signaling in lymphocytes
    Role of Calcineurin-dependent NFAT signaling in lymphocytes


    2 BioSystems Pathways for RCAN2
        Calcium signaling in the CD4+ TCR pathway
    Role of Calcineurin-dependent NFAT signaling in lymphocytes


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCAN2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for RCAN2 (Q142063 ENSP000003294544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP3CAQ082093, ENSP000003783234I2D: score=2 STRING: ENSP00000378323
    PPP3R1P630983I2D: score=1 
    TCEB1ENSP000002848114STRING: ENSP00000284811
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development NAS--
    GO:0019722calcium-mediated signaling IEA--

    RCAN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RCAN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCAN2

    1 Novoseek inferred chemical compound relationship for RCAN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 1 16516408 (1)

    Search CenterWatch for drugs/clinical trials and news about RCAN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCAN2 gene (3 alternative transcripts): 
    NM_001251973.1  NM_001251974.1  NM_005822.3  

    Unigene Cluster for RCAN2:

    Regulator of calcineurin 2
    Hs.440168  [show with all ESTs]
    Unigene Representative Sequence: NM_005822
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330430(uc003oyb.2) ENST00000371374(uc003oyc.2) ENST00000306764(uc003oyd.2)
    ENST00000405162

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCAN2
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate RCAN2 (see all 50):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-371-5p hsa-miR-9 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidRCAN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCAN2
    Clone
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    GenScript: all cDNA clones in your preferred vector: RCAN2 (NM_005822)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCAN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCAN2
    Sirion Biotech Customized lentivirus for stable overexpression of RCAN2 
                         Customized lentivirus expression plasmids for stable overexpression of RCAN2 
    Primer
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    OriGene qPCR primer pairs and template standards for RCAN2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCAN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCAN2

    Additional mRNA sequence: 

    AK090990.1 AK312392.1 AY034085.1 AY034086.1 BC038509.1 D83407.1 

    9 DOTS entries:

    DT.100024714  DT.115045  DT.100024715  DT.100754275  DT.100754281  DT.121382915  DT.99977990  DT.100753721 
    DT.100754279 

    24/148 AceView cDNA sequences (see all 148):

    AL693037 BM992373 AI354904 AA776139 AI090148 CR604948 T09144 CA848451 
    BM700160 AL119703 AI816815 BM994419 AW957141 BQ427405 BP362059 AI419039 
    BE328564 AA365104 AI306418 BX105095 AA679807 BM725011 C04976 H21189 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCAN2 expression in normal human tissues (normalized intensities)      RCAN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGCACATTA
    RCAN2 Expression
    About this image


    RCAN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             Substantia Nigra   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Human Iris Pigment Epithelial Cells (HIPEpiC)   
     
     Fibroblast
             Human Pulmonary Fibroblasts (HPF)   
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             Human Iris Pigment Epithelial Cells (HIPEpiC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Normal Human osteoblasts (NHOST)   

    See RCAN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCAN2

    SOURCE GeneReport for Unigene cluster: Hs.440168

    UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206
    Tissue specificity: Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung,
    kidney and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RCAN2 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcan25 regulator of calcineurin 2   --   17 (19.77 cM) 43801851 
    chicken
    (Gallus gallus)
    Aves RCAN26
    regulator of calcineurin 2
    72(a)
    1 ↔ 1
    3(109338625-109369202)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.41332 Transcribed sequence with moderate similarity to protein more 79.32(n)    AL892763.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.128292 Transcribed sequence with moderate similarity to protein more 77.03(n)    CD284162.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sra6
    sarah
    27(a)
    1 → many
    3R(12012656-12023315)
    worm
    (Caenorhabditis elegans)
    Secernentea rcn-16
    Calcipressin-like protein
    33(a)
    1 → many
    III(5682346-5684098)


    ENSEMBL Gene Tree for RCAN2 (if available)
    TreeFam Gene Tree for RCAN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCAN2 gene
    RCAN12  RCAN32  
    3 SIMAP similar genes for RCAN2 using alignment to 3 protein entries:     RCAN2_HUMAN (see all proteins):
    DSCR1    RCAN3    RCAN1

    RCAN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5017 SNPs in RCAN2 are shown (see all 5017)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498161721,2
    --45911118(+) ACAGAA/GGCTCT 3 -- ds50010--------
    rs624008671,2
    C--45911120(+) AGAAGC/TTCTTC 3 -- ds50013Minor allele frequency- T:0.06NA EA 242
    rs1457794681,2
    --45911184(+) CTGAAC/TAATAA 3 -- ds50010--------
    rs25840721,2
    C,F,O,A,H--45911215(-) GCACTA/GTAAGA 3 -- ds500123Minor allele frequency- G:0.39NA NS EA WA CSA 2475
    rs1814658761,2
    --45911359(+) CCTGCC/TCTCCA 3 -- ds50010--------
    rs1405929661,2
    C--45911446(+) TATGGA/GTTAAC 3 -- ds50010--------
    rs1456599041,2
    --45911458(+) CCATAC/TGTTGG 3 -- ds50010--------
    rs1382222491,2
    --45911584(+) CAGATA/GTATTT 3 -- ut310--------
    rs1848521161,2
    --45911616(+) ATACAC/TGTGCA 3 -- ut310--------
    rs1900256881,2
    --45911674(+) AGTTTG/TCAAAC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for RCAN2 (46188469 - 46438469 bp, first 250kb of RCAN2)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RCAN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659487CNV Deletion23128226
    esv270581CNV Insertion20981092
    nsv830653CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RCAN2
    DNA2.0 Custom Variant and Variant Library Synthesis for RCAN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604876    OMIM disorders: --

    7 diseases for RCAN2:    About MalaCards
    down syndrome    down syndrome critical region    thyroiditis    endometrial adenocarcinoma
    hypothyroidism    endotheliitis    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for RCAN2:
    Down syndrome

    RCAN2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for RCAN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 65.5 4 10756093 (1), 10722714 (1), 11080588 (1), 16516408 (1)

    Genetic Association Database (GAD): RCAN2
    Human Genome Epidemiology (HuGE) Navigator: RCAN2 (1 document)

    Export disorders for RCAN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCAN2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with RCAN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. (PubMed id 8662924)1, 2, 3, 9 Miyazaki T.... Seo H. (1996)
    2. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. (PubMed id 12102656)1, 2, 9 Cao X.... Seo H. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). (PubMed id 10756093)1, 9 Strippoli P.... Zannotti M. (2000)
    6. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. (PubMed id 10861295)1, 9 Fuentes J.J.... de la Luna S. (2000)
    7. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. (PubMed id 10722714)1, 9 Rothermel B....Williams R.S. (2000)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Prostaglandin F(2alpha)-F-prostanoid receptor regulat es CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcine urin-NFAT pathway. (PubMed id 19819266)1 Sales K.J....Jabbour H.N. (2009)
    10. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10231 HGNC: 3041 AceView: DSCR1L1 Ensembl:ENSG00000172348 euGenes: HUgn10231
    ECgene: RCAN2 H-InvDB: RCAN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCAN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCAN2 gene:
    Search GeneIP for patents involving RCAN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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