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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCAN2 Gene

protein-coding   GIFtS: 54
GCID: GC06M046188

regulator of calcineurin 2

(Previous name: Down syndrome critical region gene 1-like 1 )
(Previous symbol: DSCR1L1)
 Explore 9 diseases affiliated with
RCAN2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RCAN2    

Aliases
for RCAN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of Calcineurin 21 2 3     Thyroid Hormone-Responsive Protein ZAKI-42 3
DSCR1L11 2 3 5     Down Syndrome Candidate Region 1-Like 12 3
MCIP22 3 5     CSP22 5
ZAKI42 3 5     RCN22
ZAKI-41 2     Calcipressin-21
Down Syndrome Critical Region Gene 1-Like 11 2     Thyroid Hormone-Responsive (Skin Fibroblasts)2
Myocyte-Enriched Calcineurin-Interacting Protein 22 3     

External Ids:    HGNC: 30411   Entrez Gene: 102312   Ensembl: ENSG000001723487   OMIM: 6048765   UniProtKB: Q142063   

Export aliases for RCAN2 gene to outside databases

Previous GC identifers: GC06M046297 GC06M045911


Summaries
for RCAN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RCAN2:
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many
physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear
translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by
thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by
RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206
Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A.
Could play a role during central nervous system development

Gene Wiki entry for RCAN2


Genomic Views
for RCAN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCAN2 gene promoter:
         AML1a   Evi-1   YY1   NF-AT   NF-AT4   POU2F1   NF-AT2   POU2F1b   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RCAN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCAN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCAN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

RCAN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCAN2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M046188:  view genomic region     (about GC identifiers)

Start:
 46,188,469 bp from pter      End:
 46,459,709 bp from pter
Size:
 271,241 bases      Orientation:
 minus strand

Proteins
for RCAN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206 (See protein sequence)
Recommended Name: Calcipressin-2  
Size: 197 amino acids; 21997 Da
Sequence caution: Sequence=BAA11911.1; Type=Erroneous initiation;
Secondary accessions: A6ND07 B3KR46 Q5VWF7 Q5VWF8 Q8N116
Alternative splicing: 2 isoforms:  Q14206-1   Q14206-2   

Explore the universe of human proteins at neXtProt for RCAN2: NX_Q14206

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14206

    • RCAN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001238902.1  NP_001238903.1  NP_005813.2  

    ENSEMBL proteins: 
     ENSP00000329454   ENSP00000360425   ENSP00000305223   ENSP00000384317  

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    OriGene Protein Over-expression Lysate: RCAN2
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    Novus Biologicals RCAN2 Proteins
    Novus Biologicals RCAN2 Lysates
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    ProSpec Recombinant Protein for RCAN2
    Uscn Proteins for RCAN2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    RCAN2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RCAN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RCAN2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006931 Calcipressin
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q14206

    ProtoNet protein and cluster: Q14206

    1 Blocks protein family: IPB006931 Calcipressin

    UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206
    Similarity: Belongs to the RCAN family


    Function
    for RCAN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206
    Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A.
    Could play a role during central nervous system development
    Induction: By thyroid hormone

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    OriGene 3'-UTR Clone: RCAN2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCAN2
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate RCAN2 (see all 50):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-371-5p hsa-miR-9 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: RCAN2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCAN2 (see all 7)
    OriGene shRNA RFP: RCAN2
    OriGene siRNA: RCAN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCAN2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RCAN2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCAN2 (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for RCAN2

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0030346protein phosphatase 2B binding NAS--


    RCAN2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for RCAN2:
     Decreased viability with carbo  Decreased viability with pacli  Increased G1 DNA content  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-out Rcan2tm1Jmol for RCAN2
         11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rcan2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system 
     skeleton 

    RCAN2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RCAN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Role of Calcineurin-dependent NFAT signaling in lymphocytes
    		Role of Calcineurin-dependent NFAT signaling in lymphocytes1.00
    2Calcium signaling in the CD4+ TCR pathway
    		Calcium signaling in the CD4+ TCR pathway1.00


    2 BioSystems Pathways for RCAN2 
        Calcium signaling in the CD4+ TCR pathway
    Role of Calcineurin-dependent NFAT signaling in lymphocytes


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCAN2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for RCAN2 (Q142063 ENSP000003294544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP3CAQ082093, ENSP000003783234I2D: score=2 STRING: ENSP00000378323
    PPP3R1P630983I2D: score=1 
    TCEB1ENSP000002848114STRING: ENSP00000284811
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development NAS--
    GO:0019722calcium-mediated signaling IEA--


    RCAN2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RCAN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RCAN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCAN2
    1 Novoseek chemical compound relationship for RCAN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 1 16516408 (1)

    Search CenterWatch for drugs/clinical trials and news about RCAN2 

    Transcripts
    for RCAN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RCAN2 gene (3 alternative transcripts): 
    NM_001251973.1  NM_001251974.1  NM_005822.3  

    Unigene Cluster for RCAN2:

    Regulator of calcineurin 2
    Hs.440168  [show with all ESTs]
    Unigene Representative Sequence: NM_005822
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330430(uc003oyb.2) ENST00000371374(uc003oyc.2) ENST00000306764(uc003oyd.2)
    ENST00000405162

    miRNA
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    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate RCAN2 (see all 50):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-371-5p hsa-miR-9 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: RCAN2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCAN2 (see all 7)
    OriGene shRNA RFP: RCAN2
    OriGene siRNA: RCAN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCAN2
    Clone
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    GenScript: all cDNA clones in your preferred vector: RCAN2 (NM_005822)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCAN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCAN2 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RCAN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCAN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCAN2

    Additional cDNA sequence: 

    AK090990.1 AK312392.1 AY034085.1 AY034086.1 BC038509.1 D83407.1 

    9 DOTS entries:

    DT.100024714  DT.115045  DT.100024715  DT.100754275  DT.100754281  DT.121382915  DT.99977990  DT.100753721 
    DT.100754279 

    24/148 AceView cDNA sequences (see all 148):

    T09144 AI306418 H21189 CA848451 CR604948 BM992373 BU069906 BF942102 
    BM680229 AI090148 BP362059 BQ427405 BX105095 AA577420 AI816815 AA365104 
    AX746721 AI362212 AI421497 AA679807 AL693037 BM994419 AK090990 BM700160 

    GeneLoc Exon Structure


    Expression
    for RCAN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCAN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACGCACATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RCAN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Dorsal forebrain-like neurons (Generation of midbra...)Brain

    See RCAN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCAN2

    SOURCE GeneReport for Unigene cluster: Hs.440168

    UniProtKB/Swiss-Prot: RCAN2_HUMAN, Q14206
    Tissue specificity: Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung,
    kidney and pancreas

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    In Situ
    Assay Products:     
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    Orthologs
    for RCAN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RCAN2 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rcan25 regulator of calcineurin 2   --   17 (19.77 cM) 43801851 
    chicken
    (Gallus gallus)    		 Aves RCAN26
    		 Uncharacterized protein
    		 91(a)
    		 1 ↔ 1
    		 3(112530572-112563246)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.41332 Transcribed sequence with moderate similarity to protein more 79.32(n)    AL892763.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.128292 Transcribed sequence with moderate similarity to protein more 77.03(n)    CD284162.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sra6
    		 sarah
    		 27(a)
    		 1 → many
    		 3R(12012656-12023315)
    worm
    (Caenorhabditis elegans)    		 Secernentea rcn-16
    		 Calcipressin-like protein
    		 35(a)
    		 1 → many
    		 III(5682301-5684053)


    ENSEMBL Gene Tree for RCAN2 (if available)
    TreeFam Gene Tree for RCAN2 (if available) 

    Paralogs
    for RCAN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCAN2 gene
    RCAN12  RCAN32  
    4 SIMAP similar genes for RCAN2 using alignment to 3 protein entries:     RCAN2_HUMAN (see all proteins):
    DSCR1    RCAN3    RCAN1    DSCR1L2

    RCAN2 for paralogs           About GeneDecksing



    Genomic Variants
    for RCAN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4256 NCBI SNPs in RCAN2 are shown (see all 4256)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs761400141,2
    		C,F,--45912008(+) ATGTGT/CCTTTT 3 -- ut311Minor allele frequency- C:0.02NA 120
    rs37998941,2
    		H--45912132(-) CTCTTC/GTCAAT 3 -- ut314Minor allele frequency- G:0.00NS EA 420
    rs2021106171,2
    		C--45912262(-) TTTTTG/TGTTTT 3 -- ut310--------
    rs1158518431,2
    		C,F,--45912863(+) TTCATC/TCCAAT 3 -- ut311Minor allele frequency- T:0.02NA 120
    rs1136152171,2
    		--45912891(+) TGCATG/CTTTAT 3 -- ut311Minor allele frequency- C:0.50CSA 2
    rs752650991,2
    		C,F,--45913293(+) TTGAGG/TAATAT 3 -- ut311Minor allele frequency- T:0.02WA 118
    rs778282061,2
    		C,F,--45913332(+) AGGAAT/CTTCAA 3 -- ut311Minor allele frequency- C:0.02NA 120
    rs761655211,2
    		F,--45913632(+) ACTGGG/AACTGA 3 -- ut311Minor allele frequency- A:0.02EA 120
    rs1995592491,2
    		C--45913732(-) CTTATA/TAAACA 3 -- ut310--------
    rs777626421,2
    		--45913775(+) ATAATG/TGGTTA 3 -- ut311Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for RCAN2 (46188469 - 46438469 bp, first 250kb of RCAN2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RCAN2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCAN2
    DNA2.0 Custom Variant and Variant Library Synthesis for RCAN2

    Disorders / Diseases
    for RCAN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RCAN2 for disorders           About GeneDecksing

    OMIM gene information: 604876    OMIM disorders: --

    9 diseases for RCAN2:    About MalaCards
    down syndrome critical region    down syndrome    thyroiditis    endometrial adenocarcinoma
    hypothyroidism    alzheimer's disease    pharyngitis    adenocarcinoma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RCAN2:
    Down syndrome

    1 Novoseek disease relationship for RCAN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 65.5 4 10756093 (1), 10722714 (1), 11080588 (1), 16516408 (1)

    Human Genome Epidemiology (HuGE) Navigator: RCAN2 (1 document)

    Export disorders for RCAN2 gene to outside databases

    Publications
    for RCAN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCAN2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with RCAN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. (PubMed id 8662924)1, 2, 3, 9 Miyazaki T.... Seo H. (1996)
    2. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. (PubMed id 12102656)1, 2, 9 Cao X.... Seo H. (2002)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). (PubMed id 10756093)1, 9 Strippoli P.... Zannotti M. (2000)
    5. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. (PubMed id 10861295)1, 9 Fuentes J.J.... de la Luna S. (2000)
    6. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. (PubMed id 10722714)1, 9 Rothermel B....Williams R.S. (2000)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Prostaglandin F(2alpha)-F-prostanoid receptor regulat es CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcine urin-NFAT pathway. (PubMed id 19819266)1 Sales K.J....Jabbour H.N. (2009)
    9. Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis. (PubMed id 17610901)1 Gollogly L.K....Yoon S.S. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for RCAN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing RCAN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10231 HGNC: 3041 AceView: DSCR1L1 Ensembl:ENSG00000172348 euGenes: HUgn10231
    ECgene: RCAN2 H-InvDB: RCAN2

    Other Databases showing RCAN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RCAN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCAN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RCAN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RCAN2 gene:
    Search GeneIP for patents involving RCAN2

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