Aliases for RCAN2 Gene
External Ids for RCAN2 Gene
Previous Symbols for RCAN2 Gene
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for RCAN2 Gene
RCAN2 (Regulator Of Calcineurin 2) is a Protein Coding gene. Diseases associated with RCAN2 include down syndrome. Among its related pathways are GPCR Pathway and Thyroid hormone signaling pathway. GO annotations related to this gene include nucleotide binding and protein phosphatase 2B binding. An important paralog of this gene is RCAN1.
UniProtKB/Swiss-Prot for RCAN2 Gene
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development