Aliases for RCAN2 Gene
External Ids for RCAN2 Gene
Previous HGNC Symbols for RCAN2 Gene
Previous GeneCards Identifiers for RCAN2 Gene
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for RCAN2 Gene
RCAN2 (Regulator Of Calcineurin 2) is a Protein Coding gene. Diseases associated with RCAN2 include Down Syndrome. Among its related pathways are Thyroid hormone signaling pathway and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include nucleotide binding and calcium-dependent protein serine/threonine phosphatase regulator activity. An important paralog of this gene is RCAN3.
UniProtKB/Swiss-Prot for RCAN2 Gene
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.