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Aliases for RCAN2 Gene

Aliases for RCAN2 Gene

  • Regulator Of Calcineurin 2 2 3 4
  • DSCR1L1 3 4 6
  • MCIP2 3 4 6
  • ZAKI4 3 4 6
  • Myocyte-Enriched Calcineurin-Interacting Protein 2 3 4
  • Down Syndrome Critical Region Gene 1-Like 1 2 3
  • Thyroid Hormone-Responsive Protein ZAKI-4 3 4
  • Down Syndrome Candidate Region 1-Like 1 3 4
  • CSP2 3 6
  • Thyroid Hormone-Responsive (Skin Fibroblasts) 3
  • Calcipressin-2 3
  • ZAKI-4 3
  • RCN2 3

External Ids for RCAN2 Gene

Previous Symbols for RCAN2 Gene

  • DSCR1L1

Summaries for RCAN2 Gene

Entrez Gene Summary for RCAN2 Gene

  • This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RCAN2 Gene

RCAN2 (Regulator Of Calcineurin 2) is a Protein Coding gene. Diseases associated with RCAN2 include down syndrome. Among its related pathways are GPCR Pathway and Thyroid hormone signaling pathway. GO annotations related to this gene include nucleotide binding and protein phosphatase 2B binding. An important paralog of this gene is RCAN1.

UniProtKB/Swiss-Prot for RCAN2 Gene

  • Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development

Gene Wiki entry for RCAN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCAN2 Gene

Genomics for RCAN2 Gene

Genomic Location for RCAN2 Gene

46,220,730 bp from pter
46,492,067 bp from pter
271,338 bases
Minus strand

Genomic View for RCAN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCAN2 Gene

Regulatory Elements for RCAN2 Gene

Proteins for RCAN2 Gene

  • Protein details for RCAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6ND07
    • B3KR46
    • Q5VWF7
    • Q5VWF8
    • Q8N116

    Protein attributes for RCAN2 Gene

    197 amino acids
    Molecular mass:
    21997 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA11911.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RCAN2 Gene


neXtProt entry for RCAN2 Gene

Proteomics data for RCAN2 Gene at MOPED

Post-translational modifications for RCAN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCAN2 Gene

No data available for DME Specific Peptides for RCAN2 Gene

Domains for RCAN2 Gene

Protein Domains for RCAN2 Gene


  • Belongs to the RCAN family.:
    • Q14206
genes like me logo Genes that share domains with RCAN2: view

No data available for Gene Families for RCAN2 Gene

Function for RCAN2 Gene

Molecular function for RCAN2 Gene

UniProtKB/Swiss-Prot Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development
UniProtKB/Swiss-Prot Induction: By thyroid hormone

Gene Ontology (GO) - Molecular Function for RCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity IBA --
genes like me logo Genes that share ontologies with RCAN2: view
genes like me logo Genes that share phenotypes with RCAN2: view

Animal Models for RCAN2 Gene

MGI Knock Outs for RCAN2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RCAN2 Gene

Localization for RCAN2 Gene

Subcellular locations from

Jensen Localization Image for RCAN2 Gene COMPARTMENTS Subcellular localization image for RCAN2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RCAN2: view

Pathways for RCAN2 Gene

genes like me logo Genes that share pathways with RCAN2: view

Pathways by source for RCAN2 Gene

Gene Ontology (GO) - Biological Process for RCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0007614 short-term memory IEA --
GO:0019722 calcium-mediated signaling --
GO:0031987 locomotion involved in locomotory behavior IEA --
GO:0033173 calcineurin-NFAT signaling cascade IEA --
genes like me logo Genes that share ontologies with RCAN2: view

Compounds for RCAN2 Gene

(1) Novoseek inferred chemical compound relationships for RCAN2 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 1
genes like me logo Genes that share compounds with RCAN2: view

Transcripts for RCAN2 Gene

Unigene Clusters for RCAN2 Gene

Regulator of calcineurin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCAN2 Gene

No ASD Table

Relevant External Links for RCAN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RCAN2 Gene

mRNA expression in normal human tissues for RCAN2 Gene

mRNA differential expression in normal tissues according to GTEx for RCAN2 Gene

This gene is overexpressed in Heart - Left Ventricle (4.4) and Artery - Tibial (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RCAN2 Gene

SOURCE GeneReport for Unigene cluster for RCAN2 Gene Hs.440168

mRNA Expression by UniProt/SwissProt for RCAN2 Gene

Tissue specificity: Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas
genes like me logo Genes that share expressions with RCAN2: view

Orthologs for RCAN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCAN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RCAN2 37
  • 89 (a)
(Bos Taurus)
Mammalia RCAN2 36
  • 89.71 (n)
  • 96.3 (a)
RCAN2 37
  • 96 (a)
(Canis familiaris)
Mammalia RCAN2 36
  • 93 (n)
  • 98.35 (a)
RCAN2 37
  • 88 (a)
(Mus musculus)
Mammalia Rcan2 36
  • 87.79 (n)
  • 93.42 (a)
Rcan2 16
Rcan2 37
  • 93 (a)
(Monodelphis domestica)
Mammalia RCAN2 37
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RCAN2 37
  • 86 (a)
(Rattus norvegicus)
Mammalia Rcan2 36
  • 88.07 (n)
  • 93.83 (a)
(Gallus gallus)
Aves RCAN2 36
  • 80.11 (n)
  • 83.95 (a)
RCAN2 37
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rcan2 36
  • 74.9 (n)
  • 81.89 (a)
Str.4133 36
(Danio rerio)
Actinopterygii Dr.12829 36
rcan2 37
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006685 36
  • 53.5 (n)
  • 45.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta sra 36
  • 53.75 (n)
  • 47.19 (a)
sra 37
  • 24 (a)
(Caenorhabditis elegans)
Secernentea rcn-1 37
  • 29 (a)
Species with no ortholog for RCAN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCAN2 Gene

Gene Tree for RCAN2 (if available)
Gene Tree for RCAN2 (if available)

Paralogs for RCAN2 Gene

Paralogs for RCAN2 Gene

Selected SIMAP similar genes for RCAN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RCAN2: view

Variants for RCAN2 Gene

Sequence variations from dbSNP and Humsavar for RCAN2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs716493 -- 46,340,205(-) GCACC(A/G)AAGAC intron-variant
rs768605 -- 46,265,589(+) ACCAA(C/T)TGGTT intron-variant
rs867471 -- 46,465,032(+) CAATA(A/T)ACATA intron-variant
rs871728 -- 46,484,882(+) TATCT(C/T)TGGAA intron-variant
rs876121 -- 46,467,186(-) CTACA(A/G)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCAN2 Gene

Variant ID Type Subtype PubMed ID
esv2659487 CNV Deletion 23128226
nsv830653 CNV Gain 17160897
esv270581 CNV Insertion 20981092

Relevant External Links for RCAN2 Gene

HapMap Linkage Disequilibrium report

Disorders for RCAN2 Gene

(1) MalaCards Diseases for RCAN2 Gene

Search for RCAN2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RCAN2 Gene

(1) Novoseek inferred disease relationships for RCAN2 Gene

Disease -log(P) Hits PubMed IDs
down syndrome 65.5 4

Relevant External Links for RCAN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RCAN2: view

No data available for UniProtKB/Swiss-Prot for RCAN2 Gene

Publications for RCAN2 Gene

  1. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. (PMID: 8662924) Miyazaki T. … Seo H. (J. Biol. Chem. 1996) 2 3 4 23
  2. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. (PMID: 12102656) Cao X. … Seo H. (Biochem. J. 2002) 3 4 23
  3. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. (PMID: 10722714) Rothermel B. … Williams R.S. (J. Biol. Chem. 2000) 3 23
  4. A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). (PMID: 10756093) Strippoli P. … Zannotti M. (Genomics 2000) 3 23
  5. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. (PMID: 10861295) Fuentes J.J. … de la Luna S. (Hum. Mol. Genet. 2000) 3 23

Products for RCAN2 Gene

Sources for RCAN2 Gene

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