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Aliases for RCAN2 Gene

Aliases for RCAN2 Gene

  • Regulator Of Calcineurin 2 2 3 4
  • Myocyte-Enriched Calcineurin-Interacting Protein 2 3 4
  • Down Syndrome Critical Region Gene 1-Like 1 2 3
  • Thyroid Hormone-Responsive Protein ZAKI-4 3 4
  • Down Syndrome Candidate Region 1-Like 1 3 4
  • DSCR1L1 3 4
  • MCIP2 3 4
  • ZAKI4 3 4
  • Thyroid Hormone-Responsive (Skin Fibroblasts) 3
  • ZAKI-4 3
  • CSP2 3
  • RCN2 3

External Ids for RCAN2 Gene

Previous HGNC Symbols for RCAN2 Gene

  • DSCR1L1

Previous GeneCards Identifiers for RCAN2 Gene

  • GC06M046297
  • GC06M046188
  • GC06M045911

Summaries for RCAN2 Gene

Entrez Gene Summary for RCAN2 Gene

  • This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RCAN2 Gene

RCAN2 (Regulator Of Calcineurin 2) is a Protein Coding gene. Diseases associated with RCAN2 include down syndrome. Among its related pathways are GPCR Pathway and Thyroid hormone signaling pathway. GO annotations related to this gene include nucleotide binding and calcium-dependent protein serine/threonine phosphatase regulator activity. An important paralog of this gene is RCAN1.

UniProtKB/Swiss-Prot for RCAN2 Gene

  • Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development

Gene Wiki entry for RCAN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCAN2 Gene

Genomics for RCAN2 Gene

Regulatory Elements for RCAN2 Gene

Genomic Location for RCAN2 Gene

Chromosome:
6
Start:
46,220,730 bp from pter
End:
46,492,067 bp from pter
Size:
271,338 bases
Orientation:
Minus strand

Genomic View for RCAN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCAN2 Gene

Proteins for RCAN2 Gene

  • Protein details for RCAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14206-RCAN2_HUMAN
    Recommended name:
    Calcipressin-2
    Protein Accession:
    Q14206
    Secondary Accessions:
    • A6ND07
    • B3KR46
    • Q5VWF7
    • Q5VWF8
    • Q8N116

    Protein attributes for RCAN2 Gene

    Size:
    197 amino acids
    Molecular mass:
    21997 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA11911.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RCAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCAN2 Gene

Proteomics data for RCAN2 Gene at MOPED

Post-translational modifications for RCAN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCAN2 Gene

No data available for DME Specific Peptides for RCAN2 Gene

Domains & Families for RCAN2 Gene

Protein Domains for RCAN2 Gene

Suggested Antigen Peptide Sequences for RCAN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14206

UniProtKB/Swiss-Prot:

RCAN2_HUMAN :
  • Belongs to the RCAN family.
Family:
  • Belongs to the RCAN family.
genes like me logo Genes that share domains with RCAN2: view

No data available for Gene Families for RCAN2 Gene

Function for RCAN2 Gene

Molecular function for RCAN2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development
UniProtKB/Swiss-Prot Induction:
By thyroid hormone

Gene Ontology (GO) - Molecular Function for RCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity IBA --
genes like me logo Genes that share ontologies with RCAN2: view
genes like me logo Genes that share phenotypes with RCAN2: view

Animal Models for RCAN2 Gene

MGI Knock Outs for RCAN2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCAN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RCAN2 Gene

Localization for RCAN2 Gene

Gene Ontology (GO) - Cellular Components for RCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RCAN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RCAN2 Gene

Pathways & Interactions for RCAN2 Gene

genes like me logo Genes that share pathways with RCAN2: view

Pathways by source for RCAN2 Gene

Gene Ontology (GO) - Biological Process for RCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007614 short-term memory IEA --
GO:0019722 calcium-mediated signaling --
GO:0031987 locomotion involved in locomotory behavior IEA --
genes like me logo Genes that share ontologies with RCAN2: view

No data available for SIGNOR curated interactions for RCAN2 Gene

Drugs & Compounds for RCAN2 Gene

(1) Drugs for RCAN2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with RCAN2: view

Transcripts for RCAN2 Gene

Unigene Clusters for RCAN2 Gene

Regulator of calcineurin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCAN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCAN2 Gene

No ASD Table

Relevant External Links for RCAN2 Gene

GeneLoc Exon Structure for
RCAN2
ECgene alternative splicing isoforms for
RCAN2

Expression for RCAN2 Gene

mRNA expression in normal human tissues for RCAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RCAN2 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.4) and Artery - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for RCAN2 Gene

This gene is overexpressed in Retina (37.9), Spinal cord (24.5), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RCAN2 Gene



SOURCE GeneReport for Unigene cluster for RCAN2 Gene Hs.440168

mRNA Expression by UniProt/SwissProt for RCAN2 Gene

Q14206-RCAN2_HUMAN
Tissue specificity: Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas
genes like me logo Genes that share expression patterns with RCAN2: view

Protein tissue co-expression partners for RCAN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RCAN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCAN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RCAN2 35
  • 89.71 (n)
  • 96.3 (a)
RCAN2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCAN2 35
  • 93 (n)
  • 98.35 (a)
RCAN2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcan2 35
  • 87.79 (n)
  • 93.42 (a)
Rcan2 16
Rcan2 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rcan2 35
  • 88.07 (n)
  • 93.83 (a)
oppossum
(Monodelphis domestica)
Mammalia RCAN2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCAN2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RCAN2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RCAN2 35
  • 80.11 (n)
  • 83.95 (a)
RCAN2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcan2 35
  • 74.9 (n)
  • 81.89 (a)
Str.4133 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12829 35
rcan2 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006685 35
  • 53.5 (n)
  • 45.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta sra 35
  • 53.75 (n)
  • 47.19 (a)
sra 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rcn-1 36
  • 29 (a)
OneToMany
Species with no ortholog for RCAN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCAN2 Gene

ENSEMBL:
Gene Tree for RCAN2 (if available)
TreeFam:
Gene Tree for RCAN2 (if available)

Paralogs for RCAN2 Gene

Paralogs for RCAN2 Gene

(3) SIMAP similar genes for RCAN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RCAN2: view

Variants for RCAN2 Gene

Sequence variations from dbSNP and Humsavar for RCAN2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs867471 -- 46,465,032(+) CAATA(A/T)ACATA intron-variant
rs871728 -- 46,484,882(+) TATCT(C/T)TGGAA intron-variant
rs876121 -- 46,467,186(-) CTACA(A/G)GAGTT intron-variant
rs935107 -- 46,271,238(-) cagcc(C/T)tgtca intron-variant
rs935108 -- 46,271,193(-) taaat(C/G)tcttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCAN2 Gene

Variant ID Type Subtype PubMed ID
esv2659487 CNV Deletion 23128226
nsv830653 CNV Gain 17160897
esv270581 CNV Insertion 20981092

Variation tolerance for RCAN2 Gene

Residual Variation Intolerance Score: 31.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCAN2 Gene

HapMap Linkage Disequilibrium report
RCAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCAN2 Gene

Disorders for RCAN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RCAN2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
down syndrome
  • trisomy 21 syndrome
- elite association
Search RCAN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RCAN2

Genetic Association Database (GAD)
RCAN2
Human Genome Epidemiology (HuGE) Navigator
RCAN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCAN2
genes like me logo Genes that share disorders with RCAN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RCAN2 Gene

Publications for RCAN2 Gene

  1. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. (PMID: 8662924) Miyazaki T. … Seo H. (J. Biol. Chem. 1996) 2 23 67
  2. Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast. (PMID: 19273587) Mehta S. … Cunningham K.W. (Mol. Cell. Biol. 2009) 23 67
  3. Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3). (PMID: 16516408) Canaider S. … Strippoli P. (Gene 2006) 23 67
  4. Genomic organization of mouse ZAKI-4 gene that encodes ZAKI-4 alpha and beta isoforms, endogenous calcineurin inhibitors, and changes in the expression of these isoforms by thyroid hormone in adult mouse brain and heart. (PMID: 15012624) Mizuno Y. … Murata Y. (Eur. J. Endocrinol. 2004) 23 67
  5. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. (PMID: 12102656) Cao X. … Seo H. (Biochem. J. 2002) 23 67

Products for RCAN2 Gene

Sources for RCAN2 Gene

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