Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCAN1 Gene

protein-coding   GIFtS: 62
GCID: GC21M035885

Regulator Of Calcineurin 1

(Previous name: Down syndrome critical region gene 1)
(Previous symbol: DSCR1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of Calcineurin 11 2 3     DSC12 3
DSCR11 2 3 5     RCN12
CSP12 3 5     calcipressin-12
MCIP12 3 5     Calcium And Oxidant-Inducible MRNA2
Down Syndrome Critical Region Gene 11 2     Down Syndrome Candidate Region 12
Down Syndrome Critical Region Protein 12 3     Modulatory Calcineurin-Interacting Protein 12
Myocyte-Enriched Calcineurin-Interacting Protein 12 3     Near DSCR Proline-Rich Protein2
ADAPT782 3     Adapt783

External Ids:    HGNC: 30401   Entrez Gene: 18272   Ensembl: ENSG000001592007   OMIM: 6029175   UniProtKB: P538053   

Export aliases for RCAN1 gene to outside databases

Previous GC identifers: GC21M034811 GC21M021367


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCAN1 Gene:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling
pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate
region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic
overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.
Three transcript variants encoding three different isoforms have been found for this gene. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RCAN1 Gene: 
RCAN1 (regulator of calcineurin 1) is a protein-coding gene. Diseases associated with RCAN1 include down syndrome critical region, and mixed malaria, and among its related super-pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Signal transduction Activation of PKC via G-Protein coupled receptor. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RCAN2.

UniProtKB/Swiss-Prot: RCAN1_HUMAN, P53805
Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of
calcineurin A. Could play a role during central nervous system development

Gene Wiki entry for RCAN1 (DSCR1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCAN1 gene promoter:
         PPAR-gamma1   Egr-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RCAN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCAN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCAN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.1-q22.2

RCAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCAN1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M035885:  view genomic region     (about GC identifiers)

Start:
35,885,440 bp from pter      End:
35,987,441 bp from pter
Size:
102,002 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RCAN1_HUMAN, P53805 (See protein sequence)
Recommended Name: Calcipressin-1  
Size: 252 amino acids; 28079 Da
Subunit: Interacts with RAF1
Secondary accessions: D3DSF9 O00582 O00583 Q53XT0 Q6IBC6 Q7Z555 Q96R03 Q9BU69 Q9UF15 Q9UME4
Alternative splicing: 4 isoforms:  P53805-1   P53805-2   P53805-3   P53805-4   

Explore the universe of human proteins at neXtProt for RCAN1: NX_P53805

Explore proteomics data for RCAN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53805

  • RCAN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCAN1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_004405.3  NP_981962.1  NP_981963.1  

    ENSEMBL proteins: 
     ENSP00000419624   ENSP00000417926   ENSP00000370524   ENSP00000419252   ENSP00000382214  
     ENSP00000320768   ENSP00000370527   ENSP00000392438  

    Human Recombinant Protein Products for RCAN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RCAN1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RCAN1
    GenScript Custom Purified and Recombinant Proteins Services for RCAN1
    Novus Biologicals RCAN1 Proteins
    Novus Biologicals RCAN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RCAN1
    Cloud-Clone Corp. Proteins for RCAN1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    RCAN1 for ontologies           About GeneDecksing



    RCAN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RCAN1
    OriGene Custom Antibody Services for RCAN1
    GenScript Custom Superior Antibodies Services for RCAN1
    Novus Biologicals RCAN1 Antibodies
    Abcam antibodies for RCAN1
    Cloud-Clone Corp. Antibodies for RCAN1 
    ThermoFisher Antibodies for RCAN1
    LSBio Antibodies in human, mouse, rat for RCAN1 

    Assay Products for RCAN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RCAN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RCAN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RCAN1 
    Cloud-Clone Corp. CLIAs for RCAN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006931 Calcipressin

    Graphical View of Domain Structure for InterPro Entry P53805

    ProtoNet protein and cluster: P53805

    1 Blocks protein domain: IPB006931 Calcipressin

    UniProtKB/Swiss-Prot: RCAN1_HUMAN, P53805
    Similarity: Belongs to the RCAN family


    RCAN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCAN1_HUMAN, P53805
    Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of
    calcineurin A. Could play a role during central nervous system development
    Induction: By calcium

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8595418
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8595418
    GO:0005515protein binding IPI15935327
         
    RCAN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RCAN1:
     Synthetic lethal with imatinib 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rcan1):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  reproductive system  tumorigenesis 

    RCAN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RCAN1: Rcan1tm1Jmol Rcan1tm1Fmc Rcan1tm1Emar

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCAN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCAN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCAN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCAN1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RCAN1:
    hsa-let-7b (MIRT005055)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCAN1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RCAN1 (see all 15):
    hsa-miR-217 hsa-miR-4303 hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-103a hsa-miR-124 hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidRCAN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RCAN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCAN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RCAN1
    Sirion Biotech Customized adenovirus for overexpression of RCAN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RCAN1 (see all 19)
    OriGene ORF clones in mouse, rat for RCAN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RCAN1 (NM_004414)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCAN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCAN1
    Sirion Biotech Customized lentivirus for stable overexpression of RCAN1 
                         Customized lentivirus expression plasmids for stable overexpression of RCAN1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RCAN1
    Search LifeMap BioReagents cell lines for RCAN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RCAN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium signaling in the CD4+ TCR pathway
    Calcium signaling in the CD4+ TCR pathway0.38
    2fMLP Pathway
    Signal transduction Calcium signaling0.34
    3Role of Calcineurin-dependent NFAT signaling in lymphocytes
    Role of Calcineurin-dependent NFAT signaling in lymphocytes
    4Notch-mediated HES/HEY network
    Notch-mediated HES/HEY network
    5MicroRNAs in cardiomyocyte hypertrophy
    MicroRNAs in cardiomyocyte hypertrophy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RCAN1
        Signal transduction Calcium signaling


    1 GeneGo (Thomson Reuters) Pathway for RCAN1
        Signal transduction Calcium signaling

    4 BioSystems Pathways for RCAN1
        MicroRNAs in cardiomyocyte hypertrophy
    Calcium signaling in the CD4+ TCR pathway
    Role of Calcineurin-dependent NFAT signaling in lymphocytes
    Notch-mediated HES/HEY network



    RCAN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RCAN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/18 Interacting proteins for RCAN1 (P538051, 2, 3 ENSP000003207684) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACBP226942, 3, ENSP000003597194MINT-7262390 I2D: score=1 STRING: ENSP00000359719
    PPP3CAQ082093, ENSP000003783234I2D: score=2 STRING: ENSP00000378323
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    IRAK1P516173, ENSP000003589974I2D: score=1 STRING: ENSP00000358997
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS8595418
    GO:0007165signal transduction TAS8595418
    GO:0007417central nervous system development TAS8595418
    GO:0007519skeletal muscle tissue development ----
    GO:0008015blood circulation TAS8595418

    RCAN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RCAN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCAN1

    1 HMDB Compound for RCAN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    9 Novoseek inferred chemical compound relationships for RCAN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ts 16 65.9 5 15906378 (3), 14738882 (1)
    tacrolimus 46.5 1 15263820 (1)
    cyclosporin a 45.6 1 15263820 (1)
    threonine 40.6 4 12809556 (1), 11483593 (1), 16649988 (1)
    serine 31.1 4 12809556 (1), 11483593 (1), 16649988 (1)
    vegf 29.2 16 17610901 (3), 15263820 (3), 15016650 (3), 17549302 (2) (see all 6)
    calcium 15.5 17 12927602 (4), 15256217 (2), 17565986 (1), 12016333 (1) (see all 5)
    h2o2 8.2 6 9185608 (2), 19322033 (2), 12927602 (1)
    tyrosine 0 4 12927602 (1)

    Search CenterWatch for drugs/clinical trials and news about RCAN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCAN1 gene (3 alternative transcripts): 
    NM_004414.5  NM_203417.1  NM_203418.1  

    Unigene Cluster for RCAN1:

    Regulator of calcineurin 1
    Hs.282326  [show with all ESTs]
    Unigene Representative Sequence: AY325903
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487434 ENST00000482533 ENST00000481448 ENST00000381132(uc002yub.3)
    ENST00000487990 ENST00000399272(uc002yuc.3) ENST00000489903(uc002yud.3)
    ENST00000313806(uc002yue.3) ENST00000492600(uc011adx.1) ENST00000463276
    ENST00000381135 ENST00000443408

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCAN1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RCAN1 (see all 15):
    hsa-miR-217 hsa-miR-4303 hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-103a hsa-miR-124 hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidRCAN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RCAN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCAN1
    Clone
    Products:
         
    OriGene clones in human, mouse for RCAN1 (see all 19)
    OriGene ORF clones in mouse, rat for RCAN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RCAN1 (NM_004414)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCAN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCAN1
    Sirion Biotech Customized lentivirus for stable overexpression of RCAN1 
                         Customized lentivirus expression plasmids for stable overexpression of RCAN1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RCAN1
    OriGene qSTAR qPCR primer pairs in human, mouse for RCAN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RCAN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCAN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCAN1

    Additional mRNA sequence: 

    AF303449.1 AF400429.1 AK092184.1 AK095069.1 AK131569.1 AK293293.1 AK299444.1 AL049369.1 
    AY325903.1 BC002864.2 BT007363.1 CR456878.1 CR542065.1 U28833.2 U85265.2 U85266.2 
    U85267.2 

    24/25 DOTS entries (see all 25):

    DT.454487  DT.100791585  DT.91769293  DT.102842915  DT.100791577  DT.100791584  DT.100791576  DT.86856099 
    DT.40206000  DT.95356147  DT.100791581  DT.121135226  DT.121135263  DT.91650394  DT.92042220  DT.100791588 
    DT.121135219  DT.121135285  DT.121135287  DT.40117255  DT.40262747  DT.91769296  DT.95118060  DT.95236543 

    24/372 AceView cDNA sequences (see all 372):

    AK131569 BQ427531 AK092184 BU075592 AA669499 BM769816 CF272269 BM743740 
    AF303449 AI077799 NM_203418 U85266 CR590235 CB051755 BM830970 AW020396 
    CK903726 BC002864 AX747397 AI188442 BQ015151 CA425609 BX089142 AL049369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCAN1 expression in normal human tissues (normalized intensities)      RCAN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGGAAAT
    RCAN1 Expression
    About this image


    RCAN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
             optic nerve head astrocytes   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Human Perineurial Cells (HPC)   
             spinal/ganglion/dorsal root ganglion   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 3 Thymocytes Thymus
             Thymus

    See RCAN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCAN1

    SOURCE GeneReport for Unigene cluster: Hs.282326

    UniProtKB/Swiss-Prot: RCAN1_HUMAN, P53805
    Tissue specificity: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues

        SABiosciences Custom PCR Arrays for RCAN1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RCAN1
    OriGene qSTAR qPCR primer pairs in human, mouse for RCAN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RCAN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCAN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCAN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RCAN1 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcan11 , 5 regulator of calcineurin 11, 5 88.76(n)1
    93.98(a)1
      16 (53.60 cM)5
    547201  NM_001081549.11  NP_001075018.11 
     923919535 
    chicken
    (Gallus gallus)
    Aves RCAN16
    Uncharacterized protein
    82(a)
    1 ↔ 1
    1(105292501-105299313)
    lizard
    (Anolis carolinensis)
    Reptilia RCAN16
    regulator of calcineurin 1
    65(a)
    1 ↔ 1
    3(142359868-142402810)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044332.12   -- 77.02(n)    BC044332.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rcan1a1 regulator of calcineurin 1a 62.63(n)
    62.63(a)
      445222  NM_001003616.1  NP_001003616.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sra6
    sarah
    25(a)
    1 → many
    3R(12012656-12023315)
    worm
    (Caenorhabditis elegans)
    Secernentea rcn-11 Protein RCN-1 49.22(n)
    43.6(a)
      175788  NM_065822.4  NP_498223.2 


    ENSEMBL Gene Tree for RCAN1 (if available)
    TreeFam Gene Tree for RCAN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCAN1 gene
    RCAN22  RCAN32  
    3 SIMAP similar genes for RCAN1 using alignment to 2 protein entries:     RCAN1_HUMAN (see all proteins):
    DSCR1    RCAN2    RCAN3

    RCAN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2195 SNPs in RCAN1 are shown (see all 2195)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58436661,2
    C--21374952(+) TTTTTT/-CTTCG 3 -- int1 trp31Minor allele frequency- -:0.50NA 2
    rs346555541,2
    C--21385385(+) ACCAG-/TTGTCC 2 -- int10--------
    rs1827270651,2
    --21414958(+) ATATAG/TATATA 2 -- int10--------
    rs346013781,2
    C--21414960(+) ATATAT/GATAGA 2 -- int12Minor allele frequency- G:0.25NA 4
    rs2002182881,2
    --21414961(+) TATAT-/ATAGAG
            
    AGAGA
    2 -- int10--------
    rs130462531,2
    C,F--21414962(+) ATATAG/TAGAGA 2 -- int13Minor allele frequency- T:0.00NA 6
    rs1921659731,2
    --21414987(+) GAGAGA/GGGCAG 2 -- int10--------
    rs676052261,2
    C--21454563(+) GTCCC-/TCCGGT 2 -- int10--------
    rs81274371,2
    C,F,H--26434940(+) TTCAGC/AAAATA 3 -- ds50016Minor allele frequency- A:0.02NS EA CSA WA 538
    rs72765521,2
    C,F,A,H--26435017(+) CAGGGG/AAAAAG 3 -- ds500119Minor allele frequency- A:0.14NS EA NA WA CSA 2338

    HapMap Linkage Disequilibrium report for RCAN1 (35885440 - 35987441 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RCAN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv913726CNV Loss21882294
    nsv523533CNV Loss19592680
    nsv518782CNV Gain19592680
    nsv817929CNV Gain17921354
    nsv7345OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RCAN1
    DNA2.0 Custom Variant and Variant Library Synthesis for RCAN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602917    OMIM disorders: --

    18 diseases for RCAN1:    About MalaCards
    down syndrome critical region    mixed malaria    down syndrome    endometrial adenocarcinoma
    alzheimer's disease    intellectual disability    mental retardation    malaria
    huntington's disease    myocardial infarction    chronic lymphocytic leukemia    endotheliitis
    ovarian cancer    schizophrenia    adenocarcinoma    colorectal cancer
    leukemia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for RCAN1:
    Down syndrome     Mixed malaria

    RCAN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for RCAN1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 82.2 55 15906378 (5), 14738882 (3), 11080588 (3), 9185608 (2) (see all 31)
    cardiac hypertrophy 58 3 11248078 (1), 16231093 (1)
    paired helical filament 49.7 2 12582468 (1)
    neurofibrillary tangles 41.4 3 11483593 (2)
    trisomy 34.1 7 14738882 (4), 15906378 (3)
    alzheimers disease 32 12 11483593 (5), 16442855 (1), 16231093 (1), 17341486 (1)
    heart defects congenital 30.7 1 14738882 (1)
    senile plaques 24.5 4 11483593 (2)
    mental retardation 24.1 4 14668437 (2), 8595418 (1)
    neurodegeneration 11.6 2 9185608 (1), 17341486 (1)

    Genetic Association Database (GAD): RCAN1
    Human Genome Epidemiology (HuGE) Navigator: RCAN1 (3 documents)

    Export disorders for RCAN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCAN1 gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with RCAN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. (PubMed id 8595418)1, 2, 3, 9 Fuentes J.-J....Estivill X. (1995)
    2. Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. (PubMed id 12809556)1, 2, 9 Genesca L....Perez-Riba M. (2003)
    3. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. (PubMed id 10861295)1, 2, 9 Fuentes J.J.... de la Luna S. (2000)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    6. Raf-1 is a binding partner of DSCR1. (PubMed id 15935327)1, 2 Cho Y.J....Sato Y. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    10. Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. (PubMed id 9325060)1, 2 Fuentes J.-J.... Estivill X. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1827 HGNC: 3040 AceView: DSCR1 Ensembl:ENSG00000159200 euGenes: HUgn1827
    ECgene: RCAN1 H-InvDB: RCAN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCAN1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RCAN1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCAN1 gene:
    Search GeneIP for patents involving RCAN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RCAN1   OriGene RNAi products in human, mouse, rat for RCAN1  
     OriGene qPCR primer pairs and template standards for RCAN1   OriGene Protein Over-expression Lysate for RCAN1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RCAN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RCAN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RCAN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RCAN1   OriGene Custom Protein Services for RCAN1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RCAN1
     QIAGEN SeqTarget long-range PCR primers for resequencing RCAN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCAN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCAN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCAN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCAN1
     GenScript Custom Purified and Recombinant Proteins Services for RCAN1 GenScript cDNA clones with any tag delivered in your preferred vector for RCAN1
     GenScript Custom Assay Services for RCAN1 GenScript Custom Superior Antibodies Services for RCAN1
     GenScript Custom overexpressing Cell Line Services for RCAN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RCAN1 promoter
     Search Chromatin IP Primers for RCAN1
     RT2 qPCR Primer Assay in human, mouse, rat RCAN1
     GNC Network for RCAN1
     SABiosciences Custom PCR Arrays for RCAN1
     Search Tocris compounds for RCAN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RCAN1 antibodies
     RCAN1 proteins
     RCAN1 lysates
     Antibodies for RCAN1
     See all of Abcam's Antibodies, Kits and Proteins for RCAN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RCAN1




     Proteins for RCAN1
     Antibodies for RCAN1
     ELISAs for RCAN1
     CLIAs for RCAN1
     Search LifeMap BioReagents cell lines for RCAN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN1
     SwitchGear 3'UTR luciferase reporter plasmids for RCAN1
     SwitchGear Promoter luciferase reporter plasmids for RCAN1
     ThermoFisher Antibodies for RCAN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCAN1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RCAN1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCAN1
    Customized:
     lentivirus for stable overexpression of RCAN1
     lentivirus expression plasmids for stable overexpression of RCAN1
     adenovirus for overexpression of RCAN1
     LSBio Antibodies in human, mouse, rat for RCAN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RCAN1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4