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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RCAN1 Gene

protein-coding GIFtS: 62
GCID: GC21M035885

regulator of calcineurin 1

(Previous name: Down syndrome critical region gene 1 )
(Previous symbol: DSCR1)

Explore 19 diseases affiliated with
RCAN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of Calcineurin 1¹ ² ³		DSC1² ³
DSCR1¹ ² ³ ⁵		RCN1²
CSP1² ³ ⁵		Calcipressin-1¹
MCIP1² ³ ⁵		Calcium And Oxidant-Inducible MRNA²
Down Syndrome Critical Region Gene 1¹ ²		Down Syndrome Candidate Region 1²
Down Syndrome Critical Region Protein 1² ³		Modulatory Calcineurin-Interacting Protein 1²
Myocyte-Enriched Calcineurin-Interacting Protein 1² ³		Near DSCR Proline-Rich Protein²
ADAPT78² ³		Adapt78³

External Ids:	HGNC: 3040¹	Entrez Gene: 1827²	Ensembl: ENSG00000159200⁷	OMIM: 602917⁵	UniProtKB: P53805³

Export aliases for RCAN1 gene to outside databases

Previous GC identifers: GC21M034811 GC21M021367

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCAN1:

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways,

possibly affecting central nervous system development. This gene is located in the minimal candidate region for the

Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this

gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants

encoding three different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RCAN1_HUMAN, P53805

Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A.

Could play a role during central nervous system development

Gene Wiki entry for RCAN1 (DSCR1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RCAN1 gene promoter:
PPAR-gamma1 Egr-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RCAN1 promoter sequence

Search SABiosciences Chromatin IP Primers for RCAN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCAN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12 Ensembl cytogenetic band: 21q22.12 HGNC cytogenetic band: 21q22.1-q22.2

RCAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCAN1 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21M035885: view genomic region (about GC identifiers)

Start:	35,885,440 bp from pter	End:	35,987,441 bp from pter
Size:	102,002 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RCAN1_HUMAN, P53805 (See protein sequence)

Recommended Name: Calcipressin-1

Size: 252 amino acids; 28079 Da

Subunit: Interacts with RAF1

Secondary accessions: D3DSF9 O00582 O00583 Q53XT0 Q6IBC6 Q7Z555 Q96R03 Q9BU69 Q9UF15 Q9UME4

Alternative splicing: 4 isoforms: P53805-1 P53805-2 P53805-3 P53805-4

Explore the universe of human proteins at neXtProt for RCAN1: NX_P53805

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53805

RCAN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_004405.3 NP_981962.1 NP_981963.1

ENSEMBL proteins:

ENSP00000419252 ENSP00000320768 ENSP00000370524 ENSP00000382214 ENSP00000417926

ENSP00000419624 ENSP00000370527 ENSP00000392438

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	ProSpec Recombinant Protein for RCAN1
	Uscn Proteins for RCAN1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

RCAN1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RCAN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RCAN1 for domains About GeneDecksing

1 InterPro domain/family:

IPR006931 Calcipressin

Graphical View of Domain Structure for InterPro Entry P53805

ProtoNet protein and cluster: P53805

1 Blocks protein family: IPB006931 Calcipressin

UniProtKB/Swiss-Prot: RCAN1_HUMAN, P53805

Similarity: Belongs to the RCAN family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RCAN1_HUMAN, P53805

Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A.

Could play a role during central nervous system development

Induction: By calcium

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	8595418
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8595418
GO:0005515	protein binding	IPI	15935327

RCAN1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RCAN1:

Synthetic lethal with imatinib

10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Rcan1):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	reproductive system	tumorigenesis

RCAN1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for RCAN1: Rcan1^tm1Jmol Rcan1^tm1Fmc Rcan1^tm1Emar

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RCAN1

miRNA Products:		miRTarBase miRNAs that target RCAN1: hsa-let-7b (MIRT005055)

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		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RCAN1 (see all 15):
		hsa-miR-217 hsa-miR-4303 hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-103a hsa-miR-124 hsa-miR-34a

		SwitchGear 3'UTR luciferase reporter plasmid: RCAN1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signal transduction Calcium signaling

Signal transduction Calcium signaling

1.00

Signal transduction_Calcium signaling

0.97

MicroRNAs in cardiomyocyte hypertrophy

MicroRNAs in cardiomyocyte hypertrophy

1.00

Notch-mediated HES/HEY network

Notch-mediated HES/HEY network

1.00

Role of Calcineurin-dependent NFAT signaling in lymphocytes

Role of Calcineurin-dependent NFAT signaling in lymphocytes

1.00

Calcium signaling in the CD4+ TCR pathway

Calcium signaling in the CD4+ TCR pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RCAN1

Signal transduction Calcium signaling

1 GeneGo (Thomson Reuters) Pathway for RCAN1

Signal transduction Calcium signaling

4 BioSystems Pathways for RCAN1

	MicroRNAs in cardiomyocyte hypertrophy
	Calcium signaling in the CD4+ TCR pathway
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Notch-mediated HES/HEY network

RCAN1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RCAN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/18 Interacting proteins for RCAN1 (P53805^{1, 2, 3} ENSP00000320768⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKACB	P22694²^,³, ENSP00000359719⁴	MINT-7262390 I2D: score=1 STRING: ENSP00000359719
PPP3CA	Q08209³, ENSP00000378323⁴	I2D: score=2 STRING: ENSP00000378323
GSK3B	P49841³, ENSP00000324806⁴	I2D: score=1 STRING: ENSP00000324806
IRAK1	P51617³, ENSP00000358997⁴	I2D: score=1 STRING: ENSP00000358997
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	TAS	8595418
GO:0007165	signal transduction	TAS	8595418
GO:0007417	central nervous system development	TAS	8595418
GO:0007519	skeletal muscle tissue development	--	--
GO:0008015	blood circulation	TAS	8595418

RCAN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RCAN1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RCAN1

1 HMDB Compound for RCAN1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

9 Novoseek chemical compound relationships for RCAN1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ts 16	65.9	5	15906378 (3), 14738882 (1)
tacrolimus	46.5	1	15263820 (1)
cyclosporin a	45.6	1	15263820 (1)
threonine	40.6	4	12809556 (1), 11483593 (1), 16649988 (1)
serine	31.1	4	12809556 (1), 11483593 (1), 16649988 (1)
vegf	29.2	16	17610901 (3), 15263820 (3), 15016650 (3), 17549302 (2) (see all 6)
calcium	15.5	17	12927602 (4), 15256217 (2), 17565986 (1), 12016333 (1) (see all 5)
h2o2	8.2	6	9185608 (2), 19322033 (2), 12927602 (1)
tyrosine	0	4	12927602 (1)

Search CenterWatch for drugs/clinical trials and news about RCAN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RCAN1 gene (3 alternative transcripts):

NM_004414.5 NM_203417.1 NM_203418.1

Unigene Cluster for RCAN1:

Regulator of calcineurin 1

Hs.282326 [show with all ESTs]

Unigene Representative Sequence: AY325903

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000487434 ENST00000487990 ENST00000313806(uc002yue.3) ENST00000489903(uc002yud.3)

ENST00000381132(uc002yub.3) ENST00000399272(uc002yuc.3) ENST00000481448

ENST00000482533 ENST00000492600(uc011adx.1) ENST00000463276 ENST00000381135

ENST00000443408

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		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RCAN1 (see all 15):
		hsa-miR-217 hsa-miR-4303 hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-103a hsa-miR-124 hsa-miR-34a

		SwitchGear 3'UTR luciferase reporter plasmid: RCAN1 3' UTR sequence

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Additional cDNA sequence:

AF303449.1 AF400429.1 AK092184.1 AK095069.1 AK131569.1 AK293293.1 AK299444.1 AL049369.1

AY325903.1 BC002864.2 BT007363.1 CR456878.1 CR542065.1 U28833.2 U85265.2 U85266.2

U85267.2

24/25 DOTS entries (see all 25):

DT.454487 DT.100791585 DT.91769293 DT.102842915 DT.100791577 DT.100791584 DT.100791576 DT.86856099

DT.40206000 DT.95356147 DT.100791581 DT.121135226 DT.121135263 DT.91650394 DT.92042220 DT.100791588

DT.121135219 DT.121135285 DT.121135287 DT.40117255 DT.40262747 DT.91769296 DT.95118060 DT.95236543

24/372 AceView cDNA sequences (see all 372):

BM769816 AF303449 AI077799 BU075592 U85266 AK131569 BQ427531 BM743740

CB051755 CR590235 AA669499 BM830970 NM_203418 AK092184 CK903726 AW020396

BC002864 AX747397 AI188442 BQ015151 CA425609 BX089142 AL049369 AI079156

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RCAN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTGGAAAT

About this image

RCAN1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RCAN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RCAN1

SOURCE GeneReport for Unigene cluster: Hs.282326

UniProtKB/Swiss-Prot: RCAN1_HUMAN, P53805

Tissue specificity: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues

SABiosciences Custom PCR Arrays for RCAN1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCAN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RCAN1 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RCAN1⁶	Uncharacterized protein	82(a)	1 ↔ 1	1(109368997-109375722)
lizard (Anolis carolinensis)	Reptilia	RCAN1⁶	--	70(a)	1 ↔ 1	3(142393169-142402810)
African clawed frog (Xenopus laevis)	Amphibia	BC044332.1²	--	77.02(n)		BC044332.1
zebrafish (Danio rerio)	Actinopterygii	rcan1a¹	regulator of calcineurin 1a	62.63(n) 62.63(a)		445222 NM_001003616.1 NP_001003616.1
fruit fly (Drosophila melanogaster)	Insecta	sra⁶	sarah	29(a)	1 → many	3R(12012656-12023315)
worm (Caenorhabditis elegans)	Secernentea	rcn-1¹	Protein RCN-1	49.22(n) 43.6(a)		175788 NM_065822.4 NP_498223.2

ENSEMBL Gene Tree for RCAN1 (if available)
TreeFam Gene Tree for RCAN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RCAN1 gene

RCAN2² RCAN3²

4 SIMAP similar genes for RCAN1 using alignment to 2 protein entries: RCAN1_HUMAN (see all proteins):

DSCR1 RCAN2 DSCR1L2 RCAN3

RCAN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8127437^1,2	C,F,H	--	21367165(+)	`TTCAGC/AAAATA`	3	--	ds500¹		6		NS EA CSA WA	538
rs74326445^1,2	F	--	21367621(+)	`AAGGTT/CCACAG`	3	--	ds500¹		1		WA	118
rs77066172^1,2		--	21367793(+)	`GCTCCC/GTCTTA`	3	--	ut3¹		0	--	--	--	--
rs14676^1,2		--	21367826(-)	`TGAACG/TTTCTC`	3	--	ut3¹ ese³		2		MN WA	302
rs200634825^1,2	C	--	21368213(-)	`GTGGGA/GGACTA`	3	--	ut3¹		0	--	--	--	--
rs11702730^1,2	C,H	--	21368621(+)	`AATCCG/AAGAAT`	3	--	ut3¹ ese³		5		NS EA NA	422
rs112506779^1,2		--	21369102(+)	`GGACAC/TGGCCT`	3	--	ut3¹		1		CSA	2
rs62211555^1,2	C,F	--	21369103(+)	`GACACA/C/GGCCTT`	6	--	ut3¹		6		WA NA CSA	245
rs73367109^1,2	C,F	--	21369525(+)	`TGCTCG/ATGACC`	3	--	int¹		4		WA CSA EA	242
rs74535645^1,2	F	--	21370232(+)	`ATGGGC/TACTTT`	3	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for RCAN1 (35885440 - 35987441 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RCAN1
     1 CNV: 34534
     1 Indel: 22424
     1 Inversion: 37233

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RCAN1 for disorders           About GeneDecksing

OMIM gene information: 602917    OMIM disorders: --

19 diseases for RCAN1:    About MalaCards

down syndrome down syndrome critical region alzheimer's disease intellectual disability

chronic lymphocytic leukemia mixed malaria epithelial ovarian cancer lymphocytic leukemia

myocardial infarction endometrial adenocarcinoma neurodegeneration ovarian cancer

huntington's disease pharyngitis colorectal cancer leukemia

adenocarcinoma schizophrenia neuronitis

2 diseases from the University of Copenhagen DISEASES database for RCAN1:

Down syndrome Mixed malaria

10/11 Novoseek disease relationships for RCAN1 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome	82.2	55	15906378 (5), 14738882 (3), 11080588 (3), 9185608 (2) (see all 31)
cardiac hypertrophy	58	3	11248078 (1), 16231093 (1)
paired helical filament	49.7	2	12582468 (1)
neurofibrillary tangles	41.4	3	11483593 (2)
trisomy	34.1	7	14738882 (4), 15906378 (3)
alzheimers disease	32	12	11483593 (5), 16442855 (1), 16231093 (1), 17341486 (1)
heart defects congenital	30.7	1	14738882 (1)
senile plaques	24.5	4	11483593 (2)
mental retardation	24.1	4	14668437 (2), 8595418 (1)
neurodegeneration	11.6	2	9185608 (1), 17341486 (1)

Human Genome Epidemiology (HuGE) Navigator: RCAN1 (3 documents)

Export disorders for RCAN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RCAN1 gene, integrated from 9 sources (see all 103):
(articles sorted by number of sources associating them with RCAN1)

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world of online information

A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. (PubMed id 8595418)^{1, 2, 3, 9} Fuentes J.-J....Estivill X. (1995)
Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. (PubMed id 12809556)^{1, 2, 9} Genesca L....Perez-Riba M. (2003)
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. (PubMed id 10861295)^{1, 2, 9} Fuentes J.J.... de la Luna S. (2000)
Raf-1 is a binding partner of DSCR1. (PubMed id 15935327)^{1, 2} Cho Y.J....Sato Y. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. (PubMed id 9325060)^{1, 2} Fuentes J.-J.... Estivill X. (1997)
Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. (PubMed id 11483593)^{1, 9} Ermak G....Davies K.J. (2001)
Multiple oxidative stress-response members of the Adapt78 family. (PubMed id 15256217)^{1, 9} Michtalik H.J....Crawford D.R. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1827	HGNC: 3040	AceView: DSCR1	Ensembl:ENSG00000159200	euGenes: HUgn1827
ECgene: RCAN1	H-InvDB: RCAN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RCAN1	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RCAN1

Intellectual Property for RCAN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RCAN1 gene:
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GeneCards and IP:
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regulator of calcineurin 1

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regulator of calcineurin 1

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