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Aliases for RC3H2 Gene

Aliases for RC3H2 Gene

  • Ring Finger And CCCH-Type Domains 2 2 3
  • MNAB 3 4 6
  • Membrane-Associated Nucleic Acid-Binding Protein 3 4
  • Ring Finger And CCCH-Type Zinc Finger Domains 2 2 3
  • Membrane Associated DNA Binding Protein 2 3
  • RING Finger Protein 164 3 4
  • RNF164 3 4
  • Ring Finger And CCCH-Type Zinc Finger Domain-Containing Protein 2 3
  • RING Finger And CCCH-Type Zinc Finger Domain-Containing Protein 2 4
  • Membrane-Associated Nucleic Acid Binding Protein 3
  • Roquin-2 3

External Ids for RC3H2 Gene

Previous HGNC Symbols for RC3H2 Gene

  • MNAB

Previous GeneCards Identifiers for RC3H2 Gene

  • GC09M124647
  • GC09M125606
  • GC09M095226

Summaries for RC3H2 Gene

GeneCards Summary for RC3H2 Gene

RC3H2 (Ring Finger And CCCH-Type Domains 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is RC3H1.

UniProtKB/Swiss-Prot for RC3H2 Gene

  • Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RC3H2 Gene

Genomics for RC3H2 Gene

Regulatory Elements for RC3H2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RC3H2 Gene

Start:
122,844,556 bp from pter
End:
122,905,341 bp from pter
Size:
60,786 bases
Orientation:
Minus strand

Genomic View for RC3H2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RC3H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RC3H2 Gene

Proteins for RC3H2 Gene

  • Protein details for RC3H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBD1-RC3H2_HUMAN
    Recommended name:
    Roquin-2
    Protein Accession:
    Q9HBD1
    Secondary Accessions:
    • Q4VXB1
    • Q5JPD7
    • Q86ST6
    • Q8N3D6
    • Q96F27
    • Q9H5J2
    • Q9HBD2
    • Q9NWN9
    • Q9NXE1

    Protein attributes for RC3H2 Gene

    Size:
    1191 amino acids
    Molecular mass:
    131669 Da
    Quaternary structure:
    • Interacts with EDC4. Interacts with CCR4-NOT deadenylase complex.
    Miscellaneous:
    • The RING finger is highly conserved among the paralogs and among species, suggesting it may possess E3 ubiquitin ligase activity. A C. elegans homolog, rle-1, is involved in daf-16 ubiquitin-dependent degradation. Although such an activity has not be observed in mammalian cells so far, it is conceivable that RC3H2 may utilize E3 ubiquitin ligase activity in the promotion of mRNA decay (PubMed:23550652).
    SequenceCaution:
    • Sequence=BAA91340.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15634.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RC3H2 Gene

neXtProt entry for RC3H2 Gene

Proteomics data for RC3H2 Gene at MOPED

Post-translational modifications for RC3H2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RC3H2 Gene

Domains for RC3H2 Gene

Gene Families for RC3H2 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for RC3H2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBD1

UniProtKB/Swiss-Prot:

RC3H2_HUMAN :
  • Q9HBD1
Domain:
  • The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies.
  • The ROQ region is required for CDE RNA-binding. It may also be involved in localization to stress granules.
Similarity:
  • Contains 1 C3H1-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RC3H2: view

Function for RC3H2 Gene

Molecular function for RC3H2 Gene

UniProtKB/Swiss-Prot Function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity).

Gene Ontology (GO) - Molecular Function for RC3H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 10938276
GO:0003729 mRNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 24448648
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RC3H2: view
genes like me logo Genes that share phenotypes with RC3H2: view

Animal Models for RC3H2 Gene

MGI Knock Outs for RC3H2:

Animal Model Products

CRISPR Products

miRNA for RC3H2 Gene

miRTarBase miRNAs that target RC3H2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RC3H2 Gene

Localization for RC3H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RC3H2 Gene

Cytoplasm, P-body. Note=During stress, such as that induced by arsenite, localizes to cytosolic stress granules. Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger. {ECO:0000269 PubMed:20412057}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RC3H2 Gene COMPARTMENTS Subcellular localization image for RC3H2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for RC3H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0009986 cell surface IDA 10938276
genes like me logo Genes that share ontologies with RC3H2: view

Pathways for RC3H2 Gene

SuperPathways for RC3H2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RC3H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IMP 24448648
GO:0001782 B cell homeostasis IEA --
GO:0009791 post-embryonic development IEA --
GO:0010468 regulation of gene expression --
GO:0010608 posttranscriptional regulation of gene expression IEA --
genes like me logo Genes that share ontologies with RC3H2: view

No data available for Pathways by source for RC3H2 Gene

Transcripts for RC3H2 Gene

Unigene Clusters for RC3H2 Gene

Ring finger and CCCH-type domains 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RC3H2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RC3H2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RC3H2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a ·
SP1: -
SP2:
SP3: - -
SP4:
SP5: -

ExUns: 21b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for RC3H2 Gene

GeneLoc Exon Structure for
RC3H2
ECgene alternative splicing isoforms for
RC3H2

Expression for RC3H2 Gene

mRNA expression in normal human tissues for RC3H2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RC3H2 Gene

SOURCE GeneReport for Unigene cluster for RC3H2 Gene Hs.533499

mRNA Expression by UniProt/SwissProt for RC3H2 Gene

Q9HBD1-RC3H2_HUMAN
Tissue specificity: Expressed in spleen, testis, ovary and small intestine.
genes like me logo Genes that share expressions with RC3H2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RC3H2 Gene

Orthologs for RC3H2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RC3H2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RC3H2 35
  • 99.64 (n)
  • 99.66 (a)
RC3H2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RC3H2 35
  • 94.96 (n)
  • 97.31 (a)
RC3H2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
RC3H2 35
  • 95.38 (n)
  • 97.65 (a)
mouse
(Mus musculus)
Mammalia Rc3h2 35
  • 93.01 (n)
  • 95.62 (a)
Rc3h2 16
Rc3h2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RC3H2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RC3H2 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rc3h2 35
  • 92.98 (n)
  • 95.96 (a)
chicken
(Gallus gallus)
Aves RC3H2 35
  • 84.44 (n)
  • 90.83 (a)
RC3H2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RC3H2 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rc3h2 35
  • 63.13 (n)
  • 64.24 (a)
rc3h2 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta roq 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rle-1 36
  • 28 (a)
OneToMany
Species with no ortholog for RC3H2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RC3H2 Gene

ENSEMBL:
Gene Tree for RC3H2 (if available)
TreeFam:
Gene Tree for RC3H2 (if available)

Paralogs for RC3H2 Gene

Paralogs for RC3H2 Gene

Selected SIMAP similar genes for RC3H2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RC3H2: view

Variants for RC3H2 Gene

Sequence variations from dbSNP and Humsavar for RC3H2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs733329 -- 122,861,885(-) ACTCT(A/G)AACCC intron-variant
rs1053762 -- 122,855,271(-) TTTCC(A/T)GATCT reference, stop-gained
rs1147318 -- 122,906,529(-) GAGAC(A/G)GAGTC upstream-variant-2KB
rs1147319 -- 122,907,223(+) gcccg(G/T)ctaaa upstream-variant-2KB
rs1147320 -- 122,907,254(+) agaga(C/T)gggtt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RC3H2 Gene

Variant ID Type Subtype PubMed ID
esv1374808 CNV Deletion 17803354

Relevant External Links for RC3H2 Gene

HapMap Linkage Disequilibrium report
RC3H2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RC3H2 Gene

Disorders for RC3H2 Gene

No disorders were found for RC3H2 Gene.

No data available for UniProtKB/Swiss-Prot for RC3H2 Gene

Publications for RC3H2 Gene

  1. A human gene coding for a membrane-associated nucleic acid-binding protein. (PMID: 10938276) Siess D.C. … Hefeneider S.H. (J. Biol. Chem. 2000) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3

Products for RC3H2 Gene

Sources for RC3H2 Gene

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