Aliases for RC3H2 Gene
External Ids for RC3H2 Gene
Previous HGNC Symbols for RC3H2 Gene
Previous GeneCards Identifiers for RC3H2 Gene
GeneCards Summary for RC3H2 Gene
RC3H2 (Ring Finger And CCCH-Type Domains 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and mRNA binding. An important paralog of this gene is RC3H1.
UniProtKB/Swiss-Prot for RC3H2 Gene
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).