Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RC3H2 Gene

protein-coding   GIFtS: 49
GCID: GC09M125606

Ring Finger And CCCH-Type Domains 2

(Previous names: membrane associated DNA binding protein, ring finger and...)
(Previous symbol: MNAB)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ring Finger And CCCH-Type Domains 21 2     RING Finger And CCCH-Type Zinc Finger Domain-Containing Protein 22 3
MNAB1 2 3 5     RNF1642 3
Membrane Associated DNA Binding Protein1 2     RING Finger Protein 1642 3
Ring Finger And CCCH-Type Zinc Finger Domains 21 2     Membrane-Associated Nucleic Acid Binding Protein2
Membrane-Associated Nucleic Acid-Binding Protein2 3     roquin-22

External Ids:    HGNC: 214611   Entrez Gene: 545422   Ensembl: ENSG000000565867   OMIM: 6152315   UniProtKB: Q9HBD13   

Export aliases for RC3H2 gene to outside databases

Previous GC identifers: GC09M124647 GC09M095226


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RC3H2 Gene:
RC3H2 (ring finger and CCCH-type domains 2) is a protein-coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is RC3H1.

UniProtKB/Swiss-Prot: RC3H2_HUMAN, Q9HBD1
Function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive
decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF
and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This
process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and
TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation
in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages,
controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in
that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RC3H2 gene promoter:
         CUTL1   NF-AT   NF-AT4   FAC1   NF-AT2   Ik-2   POU2F1a   POU2F1b   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRC3H2 promoter sequence
   Search Chromatin IP Primers for RC3H2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RC3H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q34

RC3H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RC3H2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M125606:  view genomic region     (about GC identifiers)

Start:
125,606,835 bp from pter      End:
125,667,620 bp from pter
Size:
60,786 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RC3H2_HUMAN, Q9HBD1 (See protein sequence)
Recommended Name: Roquin-2  
Size: 1191 amino acids; 131669 Da
Subunit: Interacts with EDC4 (By similarity). Interacts with CCR4-NOT deadenylase complex (By similarity)
Miscellaneous: The RING finger is highly conserved among the paralogs and among species, suggesting it may possess
E3 ubiquitin ligase activity. A C. elegans homolog, rle-1, is involved in daf-16 ubiquitin-dependent degradation.
Although such an activity has not be observed in mammalian cells so far, it is conceivable that RC3H2 may utilize
E3 ubiquitin ligase activity in the promotion of mRNA decay (PubMed:23550652)
Sequence caution: Sequence=BAA91340.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15634.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q4VXB1 Q5JPD7 Q86ST6 Q8N3D6 Q96F27 Q9H5J2 Q9HBD2 Q9NWN9 Q9NXE1
Alternative splicing: 6 isoforms:  Q9HBD1-1   Q9HBD1-2   Q9HBD1-3   Q9HBD1-4   Q9HBD1-5   Q9HBD1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RC3H2: NX_Q9HBD1

Explore proteomics data for RC3H2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RC3H2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001094058.1  NP_061323.2  

    ENSEMBL proteins: 
     ENSP00000362774   ENSP00000474709   ENSP00000398081   ENSP00000411767   ENSP00000381663  
     ENSP00000335150   ENSP00000474148   ENSP00000349783   ENSP00000362769  

    RC3H2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RC3H2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RC3H2
    GenScript Custom Purified and Recombinant Proteins Services for RC3H2
    Novus Biologicals RC3H2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RC3H2 

     
    antibodies-online proteins for RC3H2 (2 products) 

     
    antibodies-online peptides for RC3H2

    RC3H2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RC3H2
    Novus Biologicals RC3H2 Antibodies
    Abcam antibodies for RC3H2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for RC3H2
    antibodies-online antibodies for RC3H2 (4 products) 

    RC3H2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RC3H2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RC3H2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RC3H2 
    antibodies-online kits for RC3H2 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q9HBD1

    ProtoNet protein and cluster: Q9HBD1

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: RC3H2_HUMAN, Q9HBD1
    Domain: The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies (By
    similarity)
    Domain: The ROQ region is required for CDE RNA-binding (By similarity). It may also be involved in localization to
    stress granules (By similarity)
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RC3H2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RC3H2_HUMAN, Q9HBD1
    Function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive
    decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF
    and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This
    process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and
    TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation
    in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages,
    controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in
    that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA10938276
    GO:0003723RNA binding ----
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with RC3H2           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rc3h2):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  renal/urinary system  respiratory system 

    Find genes that share phenotypes with RC3H2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rc3h2tm1.2Cgv for RC3H2

       genOway: Develop your customized and physiologically relevant rodent model for RC3H2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RC3H2:
    hsa-mir-484 (MIRT042099), hsa-mir-183-5p (MIRT047142)

    Block miRNA regulation of human, mouse, rat RC3H2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RC3H2:
    hsa-miR-656 hsa-miR-2115 hsa-miR-374b hsa-miR-374a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RC3H2
    Predesigned siRNA for gene silencing in human, mouse, rat RC3H2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RC3H2

    Clone
    Products:
         
    OriGene clones in human, mouse for RC3H2 (see all 13)
    OriGene ORF clones in mouse, rat for RC3H2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RC3H2 (NM_001100588)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RC3H2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RC3H2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RC3H2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RC3H2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RC3H2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RC3H2_HUMAN, Q9HBD1: Cytoplasm, P-body (By similarity). Note=During stress, such as that induced by arsenite,
    localizes to cytosolic stress granules. Localization to stress granules, but not to P-bodies, depends upon the
    RING-type zinc finger
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0009986cell surface IDA10938276

    Find genes that share ontologies with RC3H2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including RC3H2: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RC3H2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for RC3H2 (Q9HBD12, 3 ENSP000003497834) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TIA1P314832, 3, ENSP000004013714MINT-7711447 MINT-7711460 I2D: score=1 STRING: ENSP00000401371
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    TRIM8ENSP000003021204STRING: ENSP00000302120
    DDX6ENSP000002640184STRING: ENSP00000264018
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IMP--
    GO:0008150biological_process ND--

    Find genes that share ontologies with RC3H2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RC3H2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RC3H2 gene (2 alternative transcripts): 
    NM_001100588.1  NM_018835.2  

    Unigene Cluster for RC3H2:

    Ring finger and CCCH-type domains 2
    Hs.533499  [show with all ESTs]
    Unigene Representative Sequence: NM_001100588
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373670(uc004bnd.1) ENST00000498479 ENST00000454740 ENST00000495727
    ENST00000423239(uc004bne.4) ENST00000398671 ENST00000335387(uc011lzf.2 uc011lzg.2)
    ENST00000478216 ENST00000471874 ENST00000357244(uc010mwc.1 uc004bnc.2)
    ENST00000373665(uc004bng.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RC3H2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RC3H2:
    hsa-miR-656 hsa-miR-2115 hsa-miR-374b hsa-miR-374a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RC3H2
    Predesigned siRNA for gene silencing in human, mouse, rat RC3H2
    Clone
    Products:
         
    OriGene clones in human, mouse for RC3H2 (see all 13)
    OriGene ORF clones in mouse, rat for RC3H2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RC3H2 (NM_001100588)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RC3H2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RC3H2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RC3H2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RC3H2
      QuantiTect SYBR Green Assays in human, mouse, rat RC3H2
      QuantiFast Probe-based Assays in human, mouse, rat RC3H2

    Additional mRNA sequence: 

    AF255303.1 AF255304.1 AK000308.1 AK000720.1 AK027042.1 AK226010.1 AL834431.1 BC011688.2 
    BC044642.1 

    9 DOTS entries:

    DT.100024735  DT.213928  DT.100785934  DT.454186  DT.91845206  DT.97821646  DT.121173049  DT.99947512 
    DT.455260 

    Selected AceView cDNA sequences (see all 276):

    AA694017 AA235353 AA836013 BU618436 BE671032 AA007465 BF433077 AA516426 
    AA888615 AW452129 BI754437 W32469 AA424900 AI684847 AK123569 AV694052 
    BU623589 AI635037 CD672260 W32655 BU521051 AL603617 CB119541 AF255303 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RC3H2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a ·
    SP1:                                      -                                                                                                                     
    SP2:                                                                                                                                                            
    SP3:        -                             -                                                                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -         

    ExUns: 21b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RC3H2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RC3H2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCATTTA
    RC3H2 Expression
    About this image


    RC3H2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
    RC3H2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RC3H2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533499

    UniProtKB/Swiss-Prot: RC3H2_HUMAN, Q9HBD1
    Tissue specificity: Expressed in spleen, testis, ovary and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Array including RC3H2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RC3H2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RC3H2
    QuantiTect SYBR Green Assays in human, mouse, rat RC3H2
    QuantiFast Probe-based Assays in human, mouse, rat RC3H2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RC3H2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RC3H2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rc3h21 , 5 ring finger and CCCH-type zinc finger domains 21, 5 93.01(n)1
    95.62(a)1
      2 (24.19 cM)5
    3198171  NM_001100591.11  NP_001094061.11 
     373700695 
    chicken
    (Gallus gallus)
    Aves RC3H21 ring finger and CCCH-type domains 2 84.44(n)
    90.83(a)
      417109  XM_415394.4  XP_415394.2 
    lizard
    (Anolis carolinensis)
    Reptilia RC3H26
    ring finger and CCCH-type domains 2
    64(a)
    1 ↔ 1
    AAWZ02037919(21-8961)
    zebrafish
    (Danio rerio)
    Actinopterygii rc3h21 ring finger and CCCH-type domains 2 63.13(n)
    64.24(a)
      559834  XM_005155623.1  XP_005155680.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta roq6
    roquin
    42(a)
    1 → many
    3L(16364038-16371750)
    worm
    (Caenorhabditis elegans)
    Secernentea rle-16
    Protein RLE-1, isoform b (rle-1) mRNA, complete cd...
    28(a)
    1 → many
    III(10936246-10946499) WBGene00010923


    ENSEMBL Gene Tree for RC3H2 (if available)
    TreeFam Gene Tree for RC3H2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RC3H2 gene
    RC3H12  
    1 SIMAP similar gene for RC3H2 using alignment to 5 protein entries:     RC3H2_HUMAN (see all proteins):
    RC3H1

    Find genes that share paralogs with RC3H2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RC3H2 (see all 1088)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120010021,2
    C,F,H--125611369(+) GAACAT/CCTAAC 1 -- ds500112Minor allele frequency- C:0.03NS EA NA CSA WA 1210
    rs1830419581,2
    --125611614(+) GCACCA/GGATTG 1 -- ds50010--------
    rs783250501,2
    C--125611641(+) AGCTGA/CTTGAA 1 -- ds50010--------
    rs1863554631,2
    --125611808(+) TTTTTA/TAAAAA 1 -- ut310--------
    rs2014638261,2
    --125612128(+) TAAAA-/ACAAATT 1 -- int10--------
    rs30491561,2
    C--125612130(+) AAAAC-/AAATTAG 1 -- int10--------
    rs1916630871,2
    --125612292(+) CCTCCA/GTCGCC 1 -- int10--------
    rs1835736561,2
    --125612295(+) CCGTCA/GCCCAG 1 -- int10--------
    rs1880205931,2
    --125612578(+) AAAGTA/TATGAT 1 -- int10--------
    rs1925143011,2
    --125612589(+) AAAAAC/TTAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RC3H2 (125606835 - 125667620 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RC3H2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1374808CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RC3H2
    DNA2.0 Custom Variant and Variant Library Synthesis for RC3H2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615231    OMIM disorders: --


    Find genes that share disorders with RC3H2           About GenesLikeMe


    Export disorders for RC3H2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RC3H2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with RC3H2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human gene coding for a membrane-associated nucleic acid-binding protein. (PubMed id 10938276)1, 2, 3, 9 Siess D.C....Hefeneider S.H. (J. Biol. Chem. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Molecular control of Tfh-cell differentiation by Roquin family proteins. (PubMed id 23550652)2 Heissmeyer V. and Vogel K.U. (Immunol. Rev. 2013)
    5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    7. The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs. (PubMed id 20412057)2 Athanasopoulos V....Vinuesa C.G. (FEBS J. 2010)
    8. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54542 HGNC: 21461 AceView: MNAB Ensembl:ENSG00000056586 euGenes: HUgn54542
    ECgene: RC3H2 H-InvDB: RC3H2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RC3H2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RC3H2 gene:
    Search GeneIP for patents involving RC3H2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RC3H2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RC3H2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RC3H2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RC3H2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RC3H2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RC3H2   OriGene Custom Protein Services for RC3H2  

     
     
     Block miRNA regulation of human, mouse, rat RC3H2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RC3H2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RC3H2 Predesigned siRNA for gene silencing in human, mouse, rat RC3H2
     QuantiFast Probe-based Assays in human, mouse, rat RC3H2 QuantiTect SYBR Green Assays in human, mouse, rat RC3H2
     PCR Arrays including human, mouse, rat RC3H2 Search Chromatin IP Primers for RC3H2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RC3H2  Search GeneGlobe Interaction Network for RC3H2
     Regulatory tfbs in RC3H2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RC3H2 GenScript cDNA clones with any tag delivered in your preferred vector for RC3H2
     GenScript Custom Assay Services for RC3H2 GenScript Custom overexpressing Cell Line Services for RC3H2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RC3H2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RC3H2 antibodies
     RC3H2 proteins
     Antibodies for RC3H2
     See all of Abcam's Antibodies, Kits and Proteins for RC3H2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for RC3H2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RC3H2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RC3H2
     SwitchGear Promoter luciferase reporter plasmids for RC3H2
     Search ThermoFisher Antibodies for RC3H2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RC3H2
     Browse compounds at ApexBio
     Search Addgene for plasmids for RC3H2
      Search eBioscience for proteins for RC3H2
      Search eBioscience for elisas for RC3H2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RC3H2
     antibodies-online antibodies for RC3H2 (4 products)
     antibodies-online kits for RC3H2 (5 products)
     antibodies-online peptides for RC3H2
     antibodies-online proteins for RC3H2 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RC3H2 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4