Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RC3H1 Gene

protein-coding   GIFtS: 52
GCID: GC01M173900

Ring Finger And CCCH-Type Domains 1

(Previous name: ring finger and CCCH-type zinc finger domains 1)
  Search for RC3H1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ring Finger And CCCH-Type Domains 11 2     KIAA2025 Protein1
Ring Finger And CCCH-Type Zinc Finger Domains 11 2     ROQUIN2
RNF1982 3     RP5-1198E17.52
RING Finger And C3H Zinc Finger Protein 12 3     Probable E3 Ubiquitin-Protein Ligase Roquin2
RING Finger And CCCH-Type Zinc Finger Domain-Containing Protein 12 3     roquin-12
RING Finger Protein 1982 3     Roquin3
KIAA20253 5     

External Ids:    HGNC: 294341   Entrez Gene: 1490412   Ensembl: ENSG000001358707   OMIM: 6094245   UniProtKB: Q5TC823   

Export aliases for RC3H1 gene to outside databases

Previous GC identifers: GC01M170638 GC01M172166 GC01M145125


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RC3H1 Gene:
RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et
al., 2005 (PubMed 15917799)). The roquin protein is distinguished by the presence of a CCCH zinc finger found in
RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and
stability.(supplied by OMIM, Mar 2008)

GeneCards Summary for RC3H1 Gene:
RC3H1 (ring finger and CCCH-type domains 1) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and mRNA 3'-UTR binding. An important paralog of this gene is RC3H2.

UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
Function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive
decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF
and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This
process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and
TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation
in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages,
controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in
that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RC3H1 gene promoter:
         LHX3b/Lhx3b   Sox5   C/EBPbeta   Pbx1a   AML1a   FOXD1   Evi-1   C/EBPalpha   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRC3H1 promoter sequence
   Search Chromatin IP Primers for RC3H1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RC3H1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25.1

RC3H1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RC3H1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173900:  view genomic region     (about GC identifiers)

Start:
173,900,352 bp from pter      End:
173,991,435 bp from pter
Size:
91,084 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82 (See protein sequence)
Recommended Name: Roquin-1  
Size: 1133 amino acids; 125736 Da
Subunit: Interacts with DDX6 and EDC4 (By similarity). Interacts with CCR4-NOT deadenylase complex (By similarity)
Miscellaneous: The RING finger is highly conserved among the paralogs and among species, suggesting it may possess
E3 ubiquitin ligase activity. A C. elegans homolog, rle-1, is involved in daf-16 ubiquitin-dependent degradation.
Although such an activity has not be observed in mammalian cells so far, it is conceivable that RC3H1 may utilize
E3 ubiquitin ligase activity in the promotion of mRNA decay (PubMed:23550652)
Sequence caution: Sequence=BAC04186.1; Type=Erroneous initiation; Sequence=CAH70709.1; Type=Erroneous initiation;
Sequence=CAH70710.1; Type=Erroneous initiation; Sequence=CAI19417.1; Type=Erroneous initiation;
Sequence=CAI19419.1; Type=Erroneous initiation;
Secondary accessions: B3KVK1 Q5W180 Q5W181 Q8IVE6 Q8N9V1
Alternative splicing: 2 isoforms:  Q5TC82-1   Q5TC82-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RC3H1: NX_Q5TC82

Explore proteomics data for RC3H1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RC3H1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_742068.1  
    ENSEMBL proteins: 
     ENSP00000356669   ENSP00000356667   ENSP00000258349  

    RC3H1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RC3H1
    OriGene Protein Over-expression Lysate for RC3H1
    OriGene MassSpec for RC3H1
    OriGene Custom Protein Services for RC3H1
    GenScript Custom Purified and Recombinant Proteins Services for RC3H1
    Novus Biologicals RC3H1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RC3H1

     
    Search eBioscience for Proteins for RC3H1 

    RC3H1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RC3H1
    OriGene Custom Antibody Services for RC3H1
    Novus Biologicals RC3H1 Antibodies
    Abcam antibodies for RC3H1
    Cloud-Clone Corp. Antibodies for RC3H1
    ThermoFisher Antibodies for RC3H1
    LSBio Antibodies in human, mouse, rat for RC3H1

    RC3H1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RC3H1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RC3H1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RC3H1
    Cloud-Clone Corp. CLIAs for RC3H1
    Search eBioscience for ELISAs for RC3H1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q5TC82

    ProtoNet protein and cluster: Q5TC82

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Domain: The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies (By
    similarity)
    Domain: The ROQ region is required for CDE RNA-binding (By similarity). It may also be involved in localization to
    stress granules (By similarity)
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RC3H1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RC3H1_HUMAN, Q5TC82
    Function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive
    decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF
    and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This
    process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and
    TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation
    in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages,
    controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in
    that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003730mRNA 3'-UTR binding ISS--
    GO:0004842ubiquitin-protein ligase activity TAS19217324
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RC3H1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RC3H1:
     Decreased Salmonella enterica  

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Rc3h1) (see all 16):
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system  mortality/aging 
     nervous system  no phenotypic analysis  renal/urinary system  respiratory system  skeleton 

    Find genes that share phenotypes with RC3H1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RC3H1: Rc3h1tm1.2Mass Rc3h1tm1.2Cgv

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RC3H1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RC3H1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RC3H1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RC3H1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RC3H1:
    hsa-mir-423-5p (MIRT038022), hsa-mir-877-5p (MIRT037221)

    Block miRNA regulation of human, mouse, rat RC3H1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RC3H1 (see all 155):
    hsa-miR-411* hsa-miR-579 hsa-miR-140-5p hsa-miR-520f hsa-miR-3074-3p hsa-miR-3653 hsa-miR-759 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidRC3H1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RC3H1
    Predesigned siRNA for gene silencing in human, mouse, rat RC3H1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RC3H1

    Clone
    Products:
         
    OriGene clones in human, mouse for RC3H1 (see all 6)
    OriGene ORF clones in mouse, rat for RC3H1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RC3H1 (NM_172071)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RC3H1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RC3H1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RC3H1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RC3H1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RC3H1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RC3H1_HUMAN, Q5TC82: Cytoplasm, P-body (By similarity). Note=During stress, such as that induced by arsenite,
    localizes to cytosolic stress granules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    golgi apparatus3
    nucleus3
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005737cytoplasm ----
    GO:0010494cytoplasmic stress granule ISS--

    Find genes that share ontologies with RC3H1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including RC3H1: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RC3H1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for RC3H1 (Q5TC822, 3 ENSP000002583494) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX6P261963, ENSP000002640184I2D: score=2 STRING: ENSP00000264018
    EDC4Q6P2E93, ENSP000003518114I2D: score=2 STRING: ENSP00000351811
    FOXO1ENSP000003688804STRING: ENSP00000368880
    FOXO3ENSP000003395274STRING: ENSP00000339527
    FOXO4ENSP000003633774STRING: ENSP00000363377
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000956nuclear-transcribed mRNA catabolic process ISS--
    GO:0002634regulation of germinal center formation ISS--
    GO:0002635negative regulation of germinal center formation ISS--
    GO:0010608posttranscriptional regulation of gene expression ISS--
    GO:0016567protein ubiquitination TAS19217324

    Find genes that share ontologies with RC3H1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RC3H1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RC3H1 gene: 
    NM_172071.2  

    Unigene Cluster for RC3H1:

    Ring finger and CCCH-type domains 1
    Hs.30258  [show with all ESTs]
    Unigene Representative Sequence: NM_172071
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367696(uc001gju.4 uc010pms.2 uc010pmt.2) ENST00000367694(uc001gjv.3)
    ENST00000479099 ENST00000531594 ENST00000484867 ENST00000258349
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RC3H1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RC3H1 (see all 155):
    hsa-miR-411* hsa-miR-579 hsa-miR-140-5p hsa-miR-520f hsa-miR-3074-3p hsa-miR-3653 hsa-miR-759 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidRC3H1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RC3H1
    Predesigned siRNA for gene silencing in human, mouse, rat RC3H1
    Clone
    Products:
         
    OriGene clones in human, mouse for RC3H1 (see all 6)
    OriGene ORF clones in mouse, rat for RC3H1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RC3H1 (NM_172071)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RC3H1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RC3H1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RC3H1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RC3H1
      QuantiTect SYBR Green Assays in human, mouse, rat RC3H1
      QuantiFast Probe-based Assays in human, mouse, rat RC3H1

    Additional mRNA sequence: 

    AB095945.1 AK093501.1 AK122948.1 AY726570.1 BC136784.1 BC144408.1 BX537597.1 

    10 DOTS entries:

    DT.100786925  DT.409047  DT.99986211  DT.309694  DT.100786924  DT.40227819  DT.91743780  DT.91751598 
    DT.95357913  DT.95258980 

    Selected AceView cDNA sequences (see all 52):

    AB095945 AK122948 AU185109 CB856887 AA215703 AI807785 AA903935 BX641537 
    AA938312 AI380847 AX748170 AI858589 AI915927 BF933678 AA215702 BE550656 
    AB007961 BE883520 AI627844 H99949 CD674709 BI029559 BX105244 AK093501 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RC3H1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c ·
    SP1:                          -                                                                                         -           -                           
    SP2:                          -                                                                                                     -                           
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RC3H1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RC3H1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGCAGAT
    RC3H1 Expression
    About this image


    RC3H1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RC3H1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RC3H1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.30258

    UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Tissue specificity: Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including RC3H1: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RC3H1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RC3H1
    QuantiTect SYBR Green Assays in human, mouse, rat RC3H1
    QuantiFast Probe-based Assays in human, mouse, rat RC3H1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RC3H1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RC3H1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rc3h11 , 5 RING CCCH (C3H) domains 11, 5 90.06(n)1
    93.45(a)1
      1 (69.75 cM)5
    3813051  NM_001024952.21  NP_001020123.11 
     1609064185 
    chicken
    (Gallus gallus)
    Aves RC3H11 ring finger and CCCH-type domains 1 81.9(n)
    89(a)
      424439  XM_001234604.3  XP_001234605.2 
    lizard
    (Anolis carolinensis)
    Reptilia RC3H16
    ring finger and CCCH-type domains 1
    86(a)
    1 ↔ 1
    4(71461051-71523455)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ042254.12   -- 84.47(n)    BJ042254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-60b12.11 si:dkey-60b12.1 65.57(n)
    69.73(a)
      558213  NM_001114683.1  NP_001108155.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta roq6
    roquin
    45(a)
    1 → many
    3L(16364038-16371750)
    worm
    (Caenorhabditis elegans)
    Secernentea rle-16
    Protein RLE-1, isoform b (rle-1) mRNA, complete cd...
    30(a)
    1 → many
    III(10936246-10946499) WBGene00010923


    ENSEMBL Gene Tree for RC3H1 (if available)
    TreeFam Gene Tree for RC3H1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RC3H1 gene
    RC3H22  
    1 SIMAP similar gene for RC3H1 using alignment to 3 protein entries:     RC3H1_HUMAN (see all proteins):
    RC3H2

    Find genes that share paralogs with RC3H1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RC3H1 (see all 1204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476125351,2
    C--173900049(+) AAACC-/GAGACAC 1 -- ds50010--------
    rs1480621011,2
    C--173900079(+) TCTCAC/TTGAAT 1 -- ds50010--------
    rs671487381,2
    C--173900165(+) GTAGC-/TTAT  
            
    TTAAG
    1 -- ds50010--------
    rs585521001,2
    C--173900168(+) GCTTA-/TTTA  
            
    AGATT
    1 -- ds50010--------
    rs1417615531,2
    --173900193(+) TGTGAC/TGTCCA 1 -- ds50010--------
    rs1505676471,2
    --173900321(+) ATAAGA/CTGGCA 1 -- ds50010--------
    rs608092221,2
    C,F--173900350(+) ACACAC/TGTTCC 1 -- ds50012Minor allele frequency- T:0.05WA 120
    rs1181892171,2
    C,F--173900351(+) CACACG/ATTCCT 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1826407611,2
    --173900392(+) CAGAAA/GGCAGA 1 -- ut310--------
    rs1385813141,2
    --173900458(+) TTCTAC/TTTGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RC3H1 (173900352 - 173991435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RC3H1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4673CNV Deletion18987735
    esv2719562CNV Deletion23290073
    esv2646154CNV Deletion19546169
    esv2273536CNV Deletion18987734
    esv2668755CNV Deletion23128226
    esv9249CNV Loss19470904
    nsv872551CNV Loss21882294
    esv22323CNV Loss19812545
    nsv872550CNV Loss21882294
    nsv831937CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RC3H1
    DNA2.0 Custom Variant and Variant Library Synthesis for RC3H1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609424    OMIM disorders: --


    Find genes that share disorders with RC3H1           About GenesLikeMe


    Export disorders for RC3H1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RC3H1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with RC3H1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. (PubMed id 15917799)1, 3, 9 Vinuesa C.G....Goodnow C.C. (Nature 2005)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS. (PubMed id 19217324)1, 9 Linterman M.A....Vinuesa C.G. (Immunity 2009)
    5. Molecular control of Tfh-cell differentiation by Roquin family proteins. (PubMed id 23550652)2 Heissmeyer V. and Vogel K.U. (Immunol. Rev. 2013)
    6. ROQUIN/RC3H1 alterations are not found in angioimmunoblastic T-cell lymphoma. (PubMed id 23825522)1 Auguste T....Delfau-Larue M.H. (PLoS ONE 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Breakdown in repression of IFN-I^ mRNA leads to accumulation of self-reactive effector CD8+ T cells. (PubMed id 22685317)1 Chang P.P....Vinuesa C.G. (J. Immunol. 2012)
    9. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 149041 HGNC: 29434 AceView: KIAA0492andKIAA2025 Ensembl:ENSG00000135870 euGenes: HUgn149041
    ECgene: RC3H1 H-InvDB: RC3H1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA2025

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RC3H1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RC3H1 gene:
    Search GeneIP for patents involving RC3H1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RC3H1   OriGene RNAi products in human, mouse, rat for RC3H1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RC3H1  
     OriGene MassSpec something-or-other for RC3H1   OriGene clones in human, mouse for RC3H1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RC3H1   OriGene Purified Protein for RC3H1  
     OriGene ORF clones in mouse, rat for RC3H1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RC3H1   OriGene Custom Protein Services for RC3H1  

     
     
     Block miRNA regulation of human, mouse, rat RC3H1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RC3H1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RC3H1 Predesigned siRNA for gene silencing in human, mouse, rat RC3H1
     QuantiFast Probe-based Assays in human, mouse, rat RC3H1 QuantiTect SYBR Green Assays in human, mouse, rat RC3H1
     PCR Arrays including human, mouse, rat RC3H1 Search Chromatin IP Primers for RC3H1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RC3H1  Search GeneGlobe Interaction Network for RC3H1
     Regulatory tfbs in RC3H1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RC3H1 GenScript cDNA clones with any tag delivered in your preferred vector for RC3H1
     GenScript Custom Assay Services for RC3H1 GenScript Custom overexpressing Cell Line Services for RC3H1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RC3H1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RC3H1 antibodies
     RC3H1 lysates
     Antibodies for RC3H1
     See all of Abcam's Antibodies, Kits and Proteins for RC3H1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RC3H1
     Antibodies for RC3H1
     ELISAs for RC3H1
     CLIAs for RC3H1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RC3H1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RC3H1
     SwitchGear 3'UTR luciferase reporter plasmids for RC3H1
     SwitchGear Promoter luciferase reporter plasmids for RC3H1
     ThermoFisher Antibodies for RC3H1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RC3H1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RC3H1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RC3H1
     LSBio Antibodies in human, mouse, rat for RC3H1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RC3H1
      Search eBioscience for proteins for RC3H1
      Search eBioscience for elisas for RC3H1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RC3H1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4