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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RC3H1 Gene

protein-coding   GIFtS: 50
GCID: GC01M173900

Ring Finger And CCCH-Type Domains 1

(Previous name: ring finger and CCCH-type zinc finger domains 1)
  Search for RC3H1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger And CCCH-Type Domains 11 2     KIAA2025 Protein1
Ring Finger And CCCH-Type Zinc Finger Domains 11 2     ROQUIN2
RNF1982 3     Probable E3 Ubiquitin-Protein Ligase Roquin2
RING Finger And C3H Zinc Finger Protein 12 3     RING Finger And CCCH-Type Zinc Finger Domain-Containing Protein 12
RING Finger Protein 1982 3     roquin-12
KIAA20253 5     EC 6.3.2.-3

External Ids:    HGNC: 294341   Entrez Gene: 1490412   Ensembl: ENSG000001358707   OMIM: 6094245   UniProtKB: Q5TC823   

Export aliases for RC3H1 gene to outside databases

Previous GC identifers: GC01M170638 GC01M172166 GC01M145125


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RC3H1 Gene:
RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et
al., 2005 (PubMed 15917799)). The roquin protein is distinguished by the presence of a CCCH zinc finger found in
RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and
stability.(supplied by OMIM, Mar 2008)

GeneCards Summary for RC3H1 Gene: 
RC3H1 (ring finger and CCCH-type domains 1) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and mRNA 3'-UTR binding. An important paralog of this gene is RC3H2.

UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
Function: Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an
ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RC3H1 gene promoter:
         LHX3b/Lhx3b   Sox5   C/EBPbeta   Pbx1a   AML1a   FOXD1   Evi-1   C/EBPalpha   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRC3H1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RC3H1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RC3H1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25.1

RC3H1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RC3H1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173900:  view genomic region     (about GC identifiers)

Start:
173,900,352 bp from pter      End:
173,991,435 bp from pter
Size:
91,084 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase Roquin  
Size: 1133 amino acids; 125736 Da
Subcellular location: Cytoplasm (By similarity). Note=Localizes to cytosolic RNA granules, which are sites for
regulating mRNA translation and decay, suggesting that it may bind RNA (By similarity)
Sequence caution: Sequence=BAC04186.1; Type=Erroneous initiation; Sequence=CAH70709.1; Type=Erroneous initiation;
Sequence=CAH70710.1; Type=Erroneous initiation; Sequence=CAI19417.1; Type=Erroneous initiation;
Sequence=CAI19419.1; Type=Erroneous initiation;
Secondary accessions: B3KVK1 Q5W180 Q5W181 Q8IVE6 Q8N9V1
Alternative splicing: 2 isoforms:  Q5TC82-1   Q5TC82-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RC3H1: NX_Q5TC82

Explore proteomics data for RC3H1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TC82

  • RC3H1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RC3H1 Protein Expression
    REFSEQ proteins: NP_742068.1  
    ENSEMBL proteins: 
     ENSP00000356669   ENSP00000356667   ENSP00000258349  

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    Cloud-Clone Corp. Proteins for RC3H1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005737cytoplasm ----
    GO:0010494cytoplasmic stress granule ISS--

    RC3H1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC3H: Zinc fingers, CCCH-type domain containing
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR027370 zf-RING_LisH
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q5TC82

    ProtoNet protein and cluster: Q5TC82

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    RC3H1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RC3H1_HUMAN, Q5TC82
    Function: Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an
    ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By
    similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003730mRNA 3'-UTR binding ISS--
    GO:0004842ubiquitin-protein ligase activity TAS19217324
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RC3H1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RC3H1:
     Decreased Salmonella enterica  

         15/16 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Rc3h1) (see all 16):
     cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system 
     mortality/aging  nervous system  renal/urinary system  respiratory system  skeleton 

    RC3H1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RC3H1: Rc3h1tm1.2Cgv Rc3h1tm1.2Mass

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RC3H1 
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    SwitchGear 3'UTR luciferase reporter plasmidRC3H1 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RC3H1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for RC3H1 (Q5TC822, 3 ENSP000002583494) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EDC4Q6P2E93, ENSP000003518114I2D: score=2 STRING: ENSP00000351811
    DDX6P261963I2D: score=2 
    --P310162MINT-8105237
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000956nuclear-transcribed mRNA catabolic process ISS--
    GO:0002634regulation of germinal center formation ISS--
    GO:0002635negative regulation of germinal center formation ISS--
    GO:0010608posttranscriptional regulation of gene expression ISS--
    GO:0016567protein ubiquitination TAS19217324

    RC3H1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RC3H1

    Search CenterWatch for drugs/clinical trials and news about RC3H1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RC3H1 gene: 
    NM_172071.2  

    Unigene Cluster for RC3H1:

    Ring finger and CCCH-type domains 1
    Hs.30258  [show with all ESTs]
    Unigene Representative Sequence: NM_172071
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367696(uc001gju.4 uc010pms.2 uc010pmt.2) ENST00000367694(uc001gjv.3)
    ENST00000479099 ENST00000531594 ENST00000484867 ENST00000258349
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRC3H1 3' UTR sequence
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    Additional mRNA sequence: 

    AB095945.1 AK093501.1 AK122948.1 AY726570.1 BC136784.1 BC144408.1 BX537597.1 

    10 DOTS entries:

    DT.100786925  DT.409047  DT.99986211  DT.309694  DT.100786924  DT.40227819  DT.91743780  DT.91751598 
    DT.95357913  DT.95258980 

    24/52 AceView cDNA sequences (see all 52):

    CB856887 AI380847 AA903935 BX641537 AA938312 AB095945 AU185109 AI807785 
    AA215703 AK122948 AW205418 AK093501 AA702361 BX105244 AB007961 H99949 
    BF933678 CD674709 AI627844 BE883520 AI915927 BI029559 AA215702 BE550656 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RC3H1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c ·
    SP1:                          -                                                                                         -           -                           
    SP2:                          -                                                                                                     -                           
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RC3H1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RC3H1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGCAGAT
    RC3H1 Expression
    About this image


    See RC3H1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RC3H1

    SOURCE GeneReport for Unigene cluster: Hs.30258

    UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Tissue specificity: Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver

        SABiosciences Expression via Pathway-Focused PCR Array including RC3H1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RC3H1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RC3H1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rc3h11 , 5 RING CCCH (C3H) domains 11, 5 90.32(n)1
    93.89(a)1
      1 (69.75 cM)5
    3813051  NM_001024952.21  NP_001020123.11 
     1609064185 
    chicken
    (Gallus gallus)
    Aves RC3H11 ring finger and CCCH-type domains 1 81.93(n)
    89(a)
      424439  XM_001234604.2  XP_001234605.2 
    lizard
    (Anolis carolinensis)
    Reptilia RC3H16
    --
    Uncharacterized protein
    86(a)
    24(a)
    1 ↔ 1
    possible ortholog
    4(71461051-71523455)
    AAWZ02037919(21-8961)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ042254.12   -- 84.47(n)    BJ042254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5582131 roquin-like 65.48(n)
    69.73(a)
      558213  NM_001114683.1  NP_001108155.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta roq6
    roquin
    42(a)
    1 → many
    3L(16364038-16371750)
    worm
    (Caenorhabditis elegans)
    Secernentea rle-16
    Regulation of longevity by E3 ubiquitin-protein li...
    27(a)
    1 → many
    III(10936246-10946499)


    ENSEMBL Gene Tree for RC3H1 (if available)
    TreeFam Gene Tree for RC3H1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RC3H1 gene
    RC3H22  
    1 SIMAP similar gene for RC3H1 using alignment to 3 protein entries:     RC3H1_HUMAN (see all proteins):
    RC3H2

    RC3H1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1204 SNPs in RC3H1 are shown (see all 1204)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476125351,2
    C--173900049(+) AAACC-/GAGACAC 1 -- ds50010--------
    rs1480621011,2
    C--173900079(+) TCTCAC/TTGAAT 1 -- ds50010--------
    rs671487381,2
    C--173900165(+) GTAGC-/TTAT  
            
    TTAAG
    1 -- ds50010--------
    rs585521001,2
    C--173900168(+) GCTTA-/TTTA  
            
    AGATT
    1 -- ds50010--------
    rs1417615531,2
    --173900193(+) TGTGAC/TGTCCA 1 -- ds50010--------
    rs1505676471,2
    --173900321(+) ATAAGA/CTGGCA 1 -- ds50010--------
    rs608092221,2
    C,F--173900350(+) ACACAC/TGTTCC 1 -- ds50012Minor allele frequency- T:0.05WA 120
    rs1181892171,2
    C,F--173900351(+) CACACG/ATTCCT 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1826407611,2
    --173900392(+) CAGAAA/GGCAGA 1 -- ut310--------
    rs1385813141,2
    --173900458(+) TTCTAC/TTTGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RC3H1 (173900352 - 173991435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for RC3H1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv4673CNV Deletion18987735
    esv2719562CNV Deletion23290073
    esv2646154CNV Deletion19546169
    esv2273536CNV Deletion18987734
    esv2668755CNV Deletion23128226
    esv9249CNV Loss19470904
    nsv872551CNV Loss21882294
    esv22323CNV Loss19812545
    nsv872550CNV Loss21882294
    nsv831937CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RC3H1 for disorders           About MalaCards
    OMIM gene information: 609424    OMIM disorders: --


    RC3H1 for disorders           About GeneDecksing


    Export disorders for RC3H1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RC3H1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with RC3H1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. (PubMed id 15917799)1, 3, 9 Vinuesa C.G....Goodnow C.C. (2005)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS. (PubMed id 19217324)1, 9 Linterman M.A....Vinuesa C.G. (2009)
    5. ROQUIN/RC3H1 alterations are not found in angioimmunob lastic T-cell lymphoma. (PubMed id 23825522)1 Auguste T....Delfau-Larue M.H. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Breakdown in repression of IFN-g mRNA leads to accumul ation of self-reactive effector CD8+ T cells. (PubMed id 22685317)1 Chang P.P....Vinuesa C.G. (2012)
    8. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 149041 HGNC: 29434 AceView: KIAA0492andKIAA2025 Ensembl:ENSG00000135870 euGenes: HUgn149041
    ECgene: RC3H1 H-InvDB: RC3H1

    (According to HUGE)
    About This Section
    HUGE: KIAA2025

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RC3H1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RC3H1 gene:
    Search GeneIP for patents involving RC3H1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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