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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RC3H1 Gene

protein-coding   GIFtS: 49
GCID: GC01M173900

ring finger and CCCH-type domains 1

(Previous name: ring finger and CCCH-type zinc finger domains 1 )
 Explore 1 disease affiliated with
RC3H1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RC3H1    

Aliases
for RC3H1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ring Finger And CCCH-Type Domains 11 2     RP5-1198E17.51
RNF1981 2 3     Roquin1
KIAA20251 3 5     ROQUIN2
Ring Finger And CCCH-Type Zinc Finger Domains 11 2     Probable E3 Ubiquitin-Protein Ligase Roquin2
RING Finger And C3H Zinc Finger Protein 12 3     EC 6.3.2.-3
RING Finger Protein 1982 3     

External Ids:    HGNC: 294341   Entrez Gene: 1490412   Ensembl: ENSG000001358707   OMIM: 6094245   UniProtKB: Q5TC823   

Export aliases for RC3H1 gene to outside databases

Previous GC identifers: GC01M170638 GC01M172166 GC01M145125


Summaries
for RC3H1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RC3H1:
RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al.,
2005 (PubMed 15917799)). The roquin protein is distinguished by the presence of a CCCH zinc finger found in
RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and
stability.(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
Function: Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin
ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)




Genomic Views
for RC3H1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RC3H1 gene promoter:
         LHX3b/Lhx3b   Sox5   C/EBPbeta   Pbx1a   AML1a   FOXD1   Evi-1   C/EBPalpha   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RC3H1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RC3H1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RC3H1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25.1

RC3H1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RC3H1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173900:  view genomic region     (about GC identifiers)

Start:
 173,900,352 bp from pter      End:
 173,991,435 bp from pter
Size:
 91,084 bases      Orientation:
 minus strand

Proteins
for RC3H1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase Roquin  
Size: 1133 amino acids; 125736 Da
Subcellular location: Cytoplasm (By similarity). Note=Localizes to cytosolic RNA granules, which are sites for
regulating mRNA translation and decay, suggesting that it may bind RNA (By similarity)
Sequence caution: Sequence=BAC04186.1; Type=Erroneous initiation; Sequence=CAH70709.1; Type=Erroneous initiation;
Sequence=CAH70710.1; Type=Erroneous initiation; Sequence=CAI19417.1; Type=Erroneous initiation; Sequence=CAI19419.1;
Type=Erroneous initiation;
Secondary accessions: B3KVK1 Q5W180 Q5W181 Q8IVE6 Q8N9V1
Alternative splicing: 2 isoforms:  Q5TC82-1   Q5TC82-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RC3H1: NX_Q5TC82

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5TC82

    • RC3H1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_742068.1  
    ENSEMBL proteins: 
     ENSP00000356669   ENSP00000356667   ENSP00000258349  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005737cytoplasm ----
    GO:0010494cytoplasmic stress granule ISS--


    RC3H1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RC3H1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RC3H1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q5TC82

    ProtoNet protein and cluster: Q5TC82

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RC3H1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Function: Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin
    ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RC3H1
    8/155 QIAGEN miScript miRNA Assays for microRNAs that regulate RC3H1 (see all 155):
    hsa-miR-411* hsa-miR-579 hsa-miR-140-5p hsa-miR-520f hsa-miR-3074-3p hsa-miR-3653 hsa-miR-759 hsa-miR-502-3p
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003730mRNA 3'-UTR binding ISS--
    GO:0004842ubiquitin-protein ligase activity TAS19217324
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--


    RC3H1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RC3H1:
     Decreased Salmonella enterica  

    Animal Models:
         Mouse knock-out Rc3h1tm1.2Mass for RC3H1
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rc3h1):
     cellular  growth/size  hematopoietic system  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  renal/urinary system  respiratory system  skeleton 
     tumorigenesis 

    RC3H1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RC3H1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RC3H1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for RC3H1 (Q5TC822, 3 ENSP000002583494) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EDC4Q6P2E93, ENSP000003518114I2D: score=2 STRING: ENSP00000351811
    DDX6P261963I2D: score=2 
    --P310162MINT-8105237
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000956nuclear-transcribed mRNA catabolic process ISS--
    GO:0002634regulation of germinal center formation ISS--
    GO:0002635negative regulation of germinal center formation ISS--
    GO:0010608posttranscriptional regulation of gene expression ISS--
    GO:0016567protein ubiquitination ----


    RC3H1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RC3H1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RC3H1
    Search CenterWatch for drugs/clinical trials and news about RC3H1 

    Transcripts
    for RC3H1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RC3H1 gene: 
    NM_172071.2  

    Unigene Cluster for RC3H1:

    Ring finger and CCCH-type domains 1
    Hs.30258  [show with all ESTs]
    Unigene Representative Sequence: NM_172071
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367696(uc001gju.4 uc010pms.2 uc010pmt.2) ENST00000367694(uc001gjv.3)
    ENST00000479099 ENST00000531594 ENST00000484867 ENST00000258349

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    8/155 QIAGEN miScript miRNA Assays for microRNAs that regulate RC3H1 (see all 155):
    hsa-miR-411* hsa-miR-579 hsa-miR-140-5p hsa-miR-520f hsa-miR-3074-3p hsa-miR-3653 hsa-miR-759 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RC3H1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB095945.1 AK093501.1 AK122948.1 AY726570.1 BC136784.1 BC144408.1 BX537597.1 

    10 DOTS entries:

    DT.100786925  DT.409047  DT.99986211  DT.309694  DT.100786924  DT.40227819  DT.91743780  DT.91751598 
    DT.95357913  DT.95258980 

    24/52 AceView cDNA sequences (see all 52):

    BX641537 AI807785 AU185109 AI380847 CB856887 AK122948 AA215703 AB095945 
    AA903935 AA938312 BF933678 AI627844 AI858589 AX748170 AB007961 BE550656 
    AK093501 BX105244 AA702361 AW205418 BE883520 CD674709 BI029559 AI915927 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RC3H1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c ·
    SP1:                          -                                                                                         -           -                           
    SP2:                          -                                                                                                     -                           
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RC3H1

    Expression
    for RC3H1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RC3H1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTGCAGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RC3H1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RC3H1

    SOURCE GeneReport for Unigene cluster: Hs.30258

    UniProtKB/Swiss-Prot: RC3H1_HUMAN, Q5TC82
    Tissue specificity: Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver

        SABiosciences Expression via Pathway-Focused PCR Array including RC3H1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for RC3H1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RC3H1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RC3H11 ring finger and CCCH-type domains 1 81.93(n)
    89(a)    		   424439  XM_001234604.2  XP_001234605.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RC3H16
    		 --
    		 86(a)
    		 1 ↔ 1
    		 4(71461051-71497197)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ042254.12   -- 84.47(n)    BJ042254.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5582131 roquin-like 65.48(n)
    69.73(a)    		   558213  NM_001114683.1  NP_001108155.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta roq6
    		 roquin
    		 43(a)
    		 1 → many
    		 3L(16364038-16371750)
    worm
    (Caenorhabditis elegans)    		 Secernentea rle-16
    		 --
    		 26(a)
    		 1 → many
    		 III(10936147-10946400)


    ENSEMBL Gene Tree for RC3H1 (if available)
    TreeFam Gene Tree for RC3H1 (if available) 

    Paralogs
    for RC3H1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RC3H1 gene
    RC3H22  
    1 SIMAP similar gene for RC3H1 using alignment to 3 protein entries:     RC3H1_HUMAN (see all proteins):
    RC3H2

    RC3H1 for paralogs           About GeneDecksing



    Genomic Variants
    for RC3H1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/980 NCBI SNPs in RC3H1 are shown (see all 980)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1476125351,2
    		--173900049(+) AAACC-/GAGACAC 1 -- ds50010--------
    rs1480621011,2
    		--173900079(+) TCTCAC/TTGAAT 1 -- ds50010--------
    rs1397560211,2
    		C,--173900165(+) GTAGC-/TTAT  
                TTAAG     		1 -- ds50010--------
    rs1417615531,2
    		--173900193(+) TGTGAC/TGTCCA 1 -- ds50010--------
    rs1505676471,2
    		--173900321(+) ATAAGA/CTGGCA 1 -- ds50010--------
    rs608092221,2
    		C,--173900350(+) ACACAC/TGTTCC 1 -- ds50012Minor allele frequency- T:0.05WA 120
    rs1181892171,2
    		F,--173900351(+) CACACG/ATTCCT 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1826407611,2
    		--173900392(+) CAGAAA/GGCAGA 1 -- ut310--------
    rs1385813141,2
    		--173900458(+) TTCTAC/TTTGTT 1 -- ut310--------
    rs1872268151,2
    		--173900559(+) AAATAA/GCATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RC3H1 (173900352 - 173991435 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for RC3H1
         4 CNVs: 97557 3320 84658 65246
         5 Indels: 44470 39668 42313 60906 74776

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    Disorders / Diseases
    for RC3H1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RC3H1 for disorders           About GeneDecksing

    OMIM gene information: 609424    OMIM disorders: --

    1 disease for RC3H1:    About MalaCards
    lupus erythematosus


    Export disorders for RC3H1 gene to outside databases

    Publications
    for RC3H1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RC3H1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with RC3H1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. (PubMed id 15917799)1, 3, 9 Vinuesa C.G....Goodnow C.C. (2005)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS. (PubMed id 19217324)1, 9 Linterman M.A....Vinuesa C.G. (2009)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Breakdown in repression of IFN-g mRNA leads to accumul ation of self-reactive effector CD8+ T cells. (PubMed id 22685317)1 Chang P.P....Vinuesa C.G. (2012)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. The ROQUIN family of proteins localizes to stress gra nules via the ROQ domain and binds target mRNAs. (PubMed id 20412057)9 Athanasopoulos V....Vinuesa C.G. (2010)
    10. Evidence for microRNA-mediated regulation in rheumati c diseases. (PubMed id 19995741)9 Luo X....Yu D. (2010)

    External Searches for RC3H1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RC3H1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 149041 HGNC: 29434 AceView: KIAA0492andKIAA2025 Ensembl:ENSG00000135870 euGenes: HUgn149041
    ECgene: RC3H1 H-InvDB: RC3H1

    Other Databases showing RC3H1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA2025

    Specialized Databases showing RC3H1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RC3H1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RC3H1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RC3H1 gene:
    Search GeneIP for patents involving RC3H1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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