Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBX1 Gene

Aliases for RBX1 Gene

  • Ring-Box 1, E3 Ubiquitin Protein Ligase 2 3
  • Regulator Of Cullins 1 2 3 4
  • ROC1 3 4 6
  • RING Finger Protein 75 3 4
  • RING-Box Protein 1 3 4
  • RNF75 3 4
  • E3 Ubiquitin-Protein Ligase RBX1 3
  • RING Box Protein 1 3
  • ZYP Protein 3
  • Protein ZYP 4
  • Ring-Box 1 2
  • BA554C12.1 3
  • EC 6.3.2.- 4
  • Rbx1 4

External Ids for RBX1 Gene

Summaries for RBX1 Gene

Entrez Gene Summary for RBX1 Gene

  • This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]

GeneCards Summary for RBX1 Gene

RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with RBX1 include mulibrey nanism and invasive bladder transitional cell carcinoma. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include ubiquitin-protein transferase activity and protein complex binding. An important paralog of this gene is RNF7.

UniProtKB/Swiss-Prot for RBX1 Gene

  • E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.

Gene Wiki entry for RBX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBX1 Gene

Genomics for RBX1 Gene

Genomic Location for RBX1 Gene

Start:
40,951,347 bp from pter
End:
40,973,309 bp from pter
Size:
21,963 bases
Orientation:
Plus strand

Genomic View for RBX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBX1 Gene

Regulatory Elements for RBX1 Gene

Proteins for RBX1 Gene

  • Protein details for RBX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62877-RBX1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RBX1
    Protein Accession:
    P62877
    Secondary Accessions:
    • B2RDY1
    • Q8N6Z8
    • Q9D1S2
    • Q9WUK9
    • Q9Y254

    Protein attributes for RBX1 Gene

    Size:
    108 amino acids
    Molecular mass:
    12274 Da
    Quaternary structure:
    • Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 or CUL5 and VHL. Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 and MED8; elongin BC complex (TCEB1 and TCEB2), CUL5 and MUF1. Part of multisubunit complexes with elongin BC complex (TCEB1 and TCEB2), elongin A/TCEB3 or SOCS1 or WSB1 and CUL5. Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Probably interacts with CDC34. Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B. Interacts with UBE2M. Part of a SCF complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts with PML via FBXO3. Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation reaction of ubiquitin chains by the SCF(FBW7) complex. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and CDC34. Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein. Part of the BCR(ENC1) complex containing ENC1. Part of the BCR(GAN) complex containing GAN. Part of the BCR(KLHL41) complex containing KLHL41. Part of the BCR(KEAP1) complex containing KEAP1. Interacts with DCUN1D3.
    SequenceCaution:
    • Sequence=AAH17370.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBX1 Gene

neXtProt entry for RBX1 Gene

Proteomics data for RBX1 Gene at MOPED

Post-translational modifications for RBX1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys19, Lys20, and Lys105

Other Protein References for RBX1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RBX1 Gene

Domains for RBX1 Gene

Gene Families for RBX1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RBX1 Gene

UniProtKB/Swiss-Prot:

RBX1_HUMAN
Domain:
  • The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion:
    • P62877
Family:
  • Belongs to the RING-box family.:
    • P62877
Similarity:
  • Contains 1 RING-type zinc finger.:
    • P62877
genes like me logo Genes that share domains with RBX1: view

Function for RBX1 Gene

Molecular function for RBX1 Gene

GENATLAS Biochemistry: ring-box 1
UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.

Enzyme Numbers (IUBMB) for RBX1 Gene

Gene Ontology (GO) - Molecular Function for RBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 15983046
GO:0005515 protein binding IPI 11961546
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0019788 NEDD8 transferase activity IDA 19250909
genes like me logo Genes that share ontologies with RBX1: view
genes like me logo Genes that share phenotypes with RBX1: view

miRNA for RBX1 Gene

miRTarBase miRNAs that target RBX1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RBX1 Gene

Localization for RBX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBX1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBX1 Gene COMPARTMENTS Subcellular localization image for RBX1 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for RBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex ISS --
GO:0030891 VCB complex IEA --
GO:0031461 cullin-RING ubiquitin ligase complex IDA 22405651
genes like me logo Genes that share ontologies with RBX1: view

Pathways for RBX1 Gene

SuperPathways for RBX1 Gene

genes like me logo Genes that share pathways with RBX1: view

UniProtKB/Swiss-Prot P62877-RBX1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006513 protein monoubiquitination IDA 22358839
GO:0007219 Notch signaling pathway TAS --
GO:0016032 viral process TAS --
GO:0016567 protein ubiquitination IDA 15103331
genes like me logo Genes that share ontologies with RBX1: view

Compounds for RBX1 Gene

(3) Novoseek inferred chemical compound relationships for RBX1 Gene

Compound -log(P) Hits PubMed IDs
zinc 42.6 1
steroid 0 3
leucine 0 1
genes like me logo Genes that share compounds with RBX1: view

Transcripts for RBX1 Gene

mRNA/cDNA for RBX1 Gene

Unigene Clusters for RBX1 Gene

Ring-box 1, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBX1 Gene

No ASD Table

Relevant External Links for RBX1 Gene

GeneLoc Exon Structure for
RBX1
ECgene alternative splicing isoforms for
RBX1

Expression for RBX1 Gene

mRNA expression in normal human tissues for RBX1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBX1 Gene

SOURCE GeneReport for Unigene cluster for RBX1 Gene Hs.474949

mRNA Expression by UniProt/SwissProt for RBX1 Gene

P62877-RBX1_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with RBX1: view

Orthologs for RBX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBX1 36
  • 99.69 (n)
  • 100 (a)
RBX1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBX1 36
  • 97.22 (n)
  • 100 (a)
RBX1 37
  • 98 (a)
OneToMany
RBX1 37
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RBX1 36
  • 97.84 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Gm9840 36
  • 91.98 (n)
  • 98.15 (a)
Rbx1 16
Rbx1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBX1 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBX1 37
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBX1 36
  • 87.35 (n)
  • 100 (a)
RBX1 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBX1 37
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbx1 36
  • 81.17 (n)
  • 97.22 (a)
zebrafish
(Danio rerio)
Actinopterygii rbx1 36
  • 82.72 (n)
  • 98.15 (a)
rbx1 37
  • 98 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005202 36
  • 75.64 (n)
  • 90.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Roc1a 36
  • 78.67 (n)
  • 92 (a)
Roc1a 37
  • 68 (a)
OneToOne
Roc1a 38
  • 71 (a)
Roc1b 38
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea rbx-1 36
  • 72.9 (n)
  • 82.24 (a)
rbx-1 37
  • 80 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRT1 37
  • 52 (a)
OneToMany
HRT1 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.459 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RBX1 36
  • 71.67 (n)
  • 87 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2894 36
corn
(Zea mays)
Liliopsida Zm.4011 36
rice
(Oryza sativa)
Liliopsida Os.20521 36
wheat
(Triticum aestivum)
Liliopsida Ta.5537 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rbx1 36
  • 67.6 (n)
  • 74.77 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4811 36
Species with no ortholog for RBX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RBX1 Gene

ENSEMBL:
Gene Tree for RBX1 (if available)
TreeFam:
Gene Tree for RBX1 (if available)

Paralogs for RBX1 Gene

Paralogs for RBX1 Gene

Selected SIMAP similar genes for RBX1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RBX1 Gene

genes like me logo Genes that share paralogs with RBX1: view

Variants for RBX1 Gene

Sequence variations from dbSNP and Humsavar for RBX1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs15468 -- 40,972,594(-) AAAAA(A/C)AAAGC utr-variant-3-prime
rs2003733 -- 40,957,950(+) TTCCC(A/G)AGTAG intron-variant
rs2413631 -- 40,963,782(+) tcaag(A/G)ctgca intron-variant
rs4821978 -- 40,969,915(+) aaTTA(C/G)ctgga intron-variant
rs5751013 -- 40,954,548(+) ATCAC(A/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBX1 Gene

Variant ID Type Subtype PubMed ID
nsv428389 CNV Loss 18775914

Relevant External Links for RBX1 Gene

HapMap Linkage Disequilibrium report
RBX1

Disorders for RBX1 Gene

(8) Novoseek inferred disease relationships for RBX1 Gene

Disease -log(P) Hits PubMed IDs
smith-magenis syndrome 68.5 1
carcinoma renal cell 30.2 1
promyelocytic leukemia 27.9 1
tumors 6.74 4
necrosis 0 2
genes like me logo Genes that share disorders with RBX1: view

No data available for UniProtKB/Swiss-Prot for RBX1 Gene

Publications for RBX1 Gene

  1. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PMID: 10230407) Ohta T. … Xiong Y. (Mol. Cell 1999) 2 3 4 23
  2. The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. (PMID: 11027288) Furukawa M. … Xiong Y. (Mol. Cell. Biol. 2000) 3 4 23
  3. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PMID: 12481031) Dias D.C. … Pan Z.Q. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  4. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PMID: 12732143) Groisman R. … Nakatani Y. (Cell 2003) 3 4 23
  5. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PMID: 19250909) Huang D.T. … Schulman B.A. (Mol. Cell 2009) 3 4 23

Products for RBX1 Gene

  • Addgene plasmids for RBX1

Sources for RBX1 Gene

Back to Top

Content