RBX1 Gene
protein-coding GIFtS: 62
GCID: GC22P041347
|
|
ring-box 1, E3 ubiquitin protein ligase(Previous name: ring-box 1 )
| |
Aliases
for RBX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring-Box 1, E3 Ubiquitin Protein Ligase1 2 | | Ring-Box 11 | | RNF751 2 3 | | E3 Ubiquitin-Protein Ligase RBX12 | | ROC11 2 3 | | RING Box Protein 12 | | BA554C12.11 2 | | ZYP Protein2 | | Regulator Of Cullins 12 3 | | EC 6.3.2.-3 | | RING Finger Protein 752 3 | | Rbx13 | | RING-Box Protein 12 3 | | Protein ZYP3 |
Export aliases for RBX1 gene to outside databasesPrevious GC identifers: GC22P037961 GC22P039590 GC22P039671 GC22P024308 |
Summaries
for RBX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBX1:
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins andlikely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affectprotein turnover. Related pseudogenes exist on chromosomes 2 and 5.(provided by RefSeq, Sep 2010)
UniProtKB/Swiss-Prot: RBX1_HUMAN, P62877Function: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes whichmediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved incell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. Thefunctional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognitioncomponents. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomaldegradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to thecomplex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May berequired for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair.Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitinationof KEAP1, ENC1 and KLHL41
Gene Wiki entry for RBX1
|
Genomic Views
for RBX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBX1 gene promoter:
HOXA9 AhR Pax-3 AML1a p53 Arnt C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2RBX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P041347: view genomic region
(about GC identifiers)
Start:
|
41,347,351 bp from pter |
End:
|
41,369,313 bp from pter |
Size:
|
21,963 bases |
Orientation:
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plus strand |
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Proteins
for RBX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBX1_HUMAN, P62877 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RBX1 Size: 108 amino acids; 12274 Da
Subunit: Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7,RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 or CUL5 and VHL. Partof the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 andCUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosomeand preferentially with the hyperphosphorylated form of RNA polymerase II. Part of multisubunit E3 ubiquitin ligasecomplexes with elongin BC complex (TCEB1 and TCEB2), CUL2 and MED8; elongin BC complex (TCEB1 and TCEB2), CUL5 andMUF1. Part of multisubunit complexes with elongin BC complex (TCEB1 and TCEB2), elongin A/TCEB3 or SOCS1 or WSB1 andCUL5. Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Probably interactswith CDC34. Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1,DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B. Interactswith UBE2M. Part of a SCF complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts with PML via FBXO3.Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation reactionof ubiquitin chains by the SCF(FBW7) complex. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1and CCNF. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and CDC34.Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variableBTB domain-containing protein. Part of the BCR(ENC1) complex containing ENC1. Part of the BCR(GAN) complex containingGAN. Part of the BCR(KLHL41) complex containing KLHL41. Part of the BCR(KEAP1) complex containing KEAP1
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAH17370.2; Type=Erroneous initiation;
6/9 PDB 3D structures from  and Proteopedia  for RBX1 (see all 9):1LDJ (3D)
1LDK (3D)
1U6G (3D)
2HYE (3D)
2LGV (3D)
3DPL (3D)
Secondary accessions: B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254Explore the universe of human proteins at neXtProt for RBX1: NX_P62877
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62877
RBX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055063.1
ENSEMBL proteins: ENSP00000216225 Reactome Protein details: P62877
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
RBX1 for ontologies About GeneDecksing
RBX1 Antibody Products:
Assay Products for RBX1: |
Protein
Domains /
Families
for RBX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBX1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62877ProtoNet protein and cluster: P62877 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RBX1_HUMAN, P62877Domain: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional thirdzinc ionSimilarity: Belongs to the RING-box familySimilarity: Contains 1 RING-type zinc finger |
Function
for RBX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBX1_HUMAN, P62877Function: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes whichmediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved incell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. Thefunctional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognitioncomponents. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomaldegradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to thecomplex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May berequired for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair.Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitinationof KEAP1, ENC1 and KLHL41 Genatlas biochemistry entry for RBX1:ring-box 1
Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBX1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RBX1 (NM_014248) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBX1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBX1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
RBX1 for ontologies About GeneDecksing
10 GenomeRNAi human phenotypes for RBX1:
Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rbx1):
RBX1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RBX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/33 super-pathways (see all 33) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha | | | 3 | FBXW7 WD mutants do not bind NICD1 | | | 4 | Antigen processing: Ubiquitination & Proteasome degradation | | | 5 | Cell cycle_Role of SCF complex in cell cycle regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for RBX1 (see all 6)
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RBX1
1 
Cell Signaling Technology (CST) Pathway for RBX1
5  GeneGo (Thomson Reuters) Pathways for RBX1
3  BioSystems Pathways for RBX1
5/38 
Reactome Pathways for RBX1 (see all 38)
5/10 
Kegg Pathways (Kegg details for RBX1) (see all 10):
UniProtKB/Swiss-Prot: RBX1_HUMAN, P62877Pathway: Protein modification; protein ubiquitination
RBX1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBX1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/348 Interacting proteins for RBX1 (P628771, 2, 3 ENSP000002162254) via UniProtKB, MINT, STRING, and/or I2D (see all 348)
About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
RBX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RBX1 for compounds About GeneDecksing
 Browse Tocris compounds for RBX1
3 Novoseek chemical compound relationships for RBX1 gene About this table
Search CenterWatch for drugs/clinical trials and news about RBX1
|
Transcripts
for RBX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBX1 gene: NM_014248.3 Unigene Cluster for RBX1: Ring-box 1, E3 ubiquitin protein ligase Hs.474949 [show with all ESTs]Unigene Representative Sequence: BU1558003 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476110 ENST00000216225(uc003azk.3) ENST00000467617
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBX1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBX1 (NM_014248) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBX1 |
Additional cDNA sequence: AF085906.1 AF140598.1 AF142059.1 AK315722.1 AY099360.1 BC001466.2 BC017370.1 CR456560.1 12 DOTS entries: DT.99988559 DT.91760128 DT.100825475 DT.91751456 DT.120645894 DT.95124659 DT.95124675 DT.75152194 DT.97809928 DT.100037803 DT.120645905 DT.95300188 24/305 AceView cDNA sequences (see all 305): BG054985 BM757406 AI310807 AW239094 AW163628 BC001466 CB113476 BM670693 BU169268 BM667060 W73052 D52876 AI343871 BU507446 AA658037 BF512968 AW161957 BU729543 AW117478 AF085906 BE256643 AI494283 F25684 NM_014248
GeneLoc Exon Structure
|
Expression
for RBX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTCACTT
About this image
See RBX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBX1
SOURCE GeneReport for Unigene cluster: Hs.474949
UniProtKB/Swiss-Prot: RBX1_HUMAN, P62877Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Array including RBX1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBX1 |
Orthologs
for RBX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBX1 gene from 8/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RBX16 |
Uncharacterized protein |
100(a) |
1 ↔ 1 |
1(51749343-51758908) |
lizard
(Anolis carolinensis) |
Reptilia |
RBX16 |
-- |
99(a) |
1 ↔ 1 |
5(26052047-26056273) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ621900.12 |
-- |
81.6(n) |
|
BJ621900.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AI106413.12 |
-- |
82.74(n) |
|
AI106413.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Roc1a3 |
smoothened receptor signaling pathway |
71(a)
(best of 2) |
|
1B13 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
rbx-16 |
RING-box protein 1 |
78(a) |
1 ↔ 1 |
V(9689658-9690591) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RBX11 |
RING-box protein 1 |
72.11(n)
87.76(a) |
|
832179 NM_001161254.1 NP_001154726.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.205212 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
80.92(n) |
|
AK099287.1 |
ENSEMBL Gene Tree for RBX1 (if available)
TreeFam Gene Tree for RBX1 (if available) |
Paralogs
for RBX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBX1 gene
- RNF72
2 SIMAP similar genes for RBX1 using alignment to 1 protein entry: RBX1_HUMAN:RNF7 ANAPC11
RBX1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RBX1
PGOHUM00000240695 PGOHUM00000235674
|
Genomic Variants
for RBX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBX1 (41347351 - 41369313 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBX1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBX1 |
|
Disorders
/ Diseases
for RBX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBX1 for disorders About GeneDecksing
OMIM gene information: 603814
OMIM disorders: --
20  diseases for RBX1: About MalaCardssmith-magenis syndrome 3-m syndrome mulibrey nanism xeroderma pigmentosum
renal clear cell carcinoma cockayne syndrome renal cell carcinoma skin melanoma
gout breast cancer kidney cancer neurodegeneration
gastric cancer melanoma carcinoma hypoxia
thyroiditis malaria neuronitis von hippel-lindau disease
8 Novoseek disease relationships for RBX1 gene About this table
Export disorders for RBX1 gene to outside databases
|
Publications
for RBX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBX1 gene, integrated from 9 sources (see all 305):
(articles sorted by number of sources associating them with RBX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PubMed id 10230407)1, 2, 3, 9 Ohta T.... Xiong Y. (1999)
- Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. (PubMed id 10213691)1, 2, 3 Kamura T.... Conaway J.W. (1999)
- The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. (PubMed id 11027288)1, 2, 9 Furukawa M.... Xiong Y. (2000)
- Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PubMed id 14739464)1, 2, 9 Wertz I.E.... Dixit V.M. (2004)
- CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PubMed id 12481031)1, 2, 9 Dias D.C.... Pan Z.Q. (2002)
- E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2, 9 Huang D.T....Schulman B.A. (2009)
- The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2, 9 Groisman R.... Nakatani Y. (2003)
- SCF(Cyclin F) controls centrosome homeostasis and mit otic fidelity through CP110 degradation. (PubMed id 20596027)1, 2 D'Angiolella V....Pagano M. (2010)
- Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. (PubMed id 19112177)1, 2 Cen B....Weinstein I.B. (2009)
- PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PubMed id 18809579)1, 2 Shima Y....Kitabayashi I. (2008)
|
External Searches for RBX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBX1 gene
(According to HUGE)
About This Section
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Specialized Databases showing RBX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for RBX1 gene:
Search GeneIP for patents involving RBX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RBX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for RBX1 | | OriGene shRNA RFP for RBX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBX1 | | | OriGene Protein Over-expression Lysate for RBX1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBX1 | | OriGene 3'-UTR Clone for RBX1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RBX1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RBX1 | | OriGene Custom Protein Services for RBX1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBX1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBX1 |
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| | Antibodies & Assays for RBX1 |
| | | | Search Tocris compounds for RBX1 |
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 | | | RBX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBX1 |
|  |  |  | | | | ThermoFisher Antibodies for RBX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBX1 |
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