Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBPMS2 Gene

Aliases for RBPMS2 Gene

  • RNA Binding Protein With Multiple Splicing 2 2 3 5

External Ids for RBPMS2 Gene

Previous GeneCards Identifiers for RBPMS2 Gene

  • GC15M062612
  • GC15U900325
  • GC15M062747
  • GC15M062819
  • GC15M065032
  • GC15M041857

Summaries for RBPMS2 Gene

GeneCards Summary for RBPMS2 Gene

RBPMS2 (RNA Binding Protein With Multiple Splicing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBPMS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBPMS2 Gene

Genomics for RBPMS2 Gene

Regulatory Elements for RBPMS2 Gene

Enhancers for RBPMS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RBPMS2 on UCSC Golden Path with GeneCards custom track

Promoters for RBPMS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBPMS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBPMS2 Gene

64,739,892 bp from pter
64,775,587 bp from pter
35,696 bases
Minus strand

Genomic View for RBPMS2 Gene

Genes around RBPMS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBPMS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBPMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBPMS2 Gene

Proteins for RBPMS2 Gene

  • Protein details for RBPMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein with multiple splicing 2
    Protein Accession:
    Secondary Accessions:
    • A2RRG0

    Protein attributes for RBPMS2 Gene

    209 amino acids
    Molecular mass:
    22497 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBPMS2 Gene

    Alternative splice isoforms for RBPMS2 Gene


neXtProt entry for RBPMS2 Gene

Proteomics data for RBPMS2 Gene at MOPED

Post-translational modifications for RBPMS2 Gene

  • Ubiquitination at Lys 204
  • Modification sites at PhosphoSitePlus

Other Protein References for RBPMS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBPMS2 Gene

Domains & Families for RBPMS2 Gene

Gene Families for RBPMS2 Gene

Protein Domains for RBPMS2 Gene

Suggested Antigen Peptide Sequences for RBPMS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBPMS2: view

Function for RBPMS2 Gene

Gene Ontology (GO) - Molecular Function for RBPMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with RBPMS2: view
genes like me logo Genes that share phenotypes with RBPMS2: view

Animal Model Products

miRNA for RBPMS2 Gene

miRTarBase miRNAs that target RBPMS2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBPMS2 Gene

Localization for RBPMS2 Gene

Subcellular locations from

Jensen Localization Image for RBPMS2 Gene COMPARTMENTS Subcellular localization image for RBPMS2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBPMS2 Gene

Pathways & Interactions for RBPMS2 Gene

SuperPathways for RBPMS2 Gene

No Data Available

Interacting Proteins for RBPMS2 Gene

Gene Ontology (GO) - Biological Process for RBPMS2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RBPMS2 Gene

Drugs & Compounds for RBPMS2 Gene

No Compound Related Data Available

Transcripts for RBPMS2 Gene

mRNA/cDNA for RBPMS2 Gene

Unigene Clusters for RBPMS2 Gene

RNA binding protein with multiple splicing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for RBPMS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBPMS2 Gene

mRNA expression in normal human tissues for RBPMS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBPMS2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x8.7), Heart - Left Ventricle (x8.1), Colon - Sigmoid (x4.7), Esophagus - Gastroesophageal Junction (x4.2), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for RBPMS2 Gene

This gene is overexpressed in Fetal heart (12.1), Peripheral blood mononuclear cells (10.4), Platelet (9.3), Colon (8.8), Urinary Bladder (8.1), Rectum (6.7), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBPMS2 Gene

SOURCE GeneReport for Unigene cluster for RBPMS2 Gene Hs.436518

genes like me logo Genes that share expression patterns with RBPMS2: view

Protein tissue co-expression partners for RBPMS2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RBPMS2 Gene

Orthologs for RBPMS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBPMS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RBPMS2 35
  • 89.63 (n)
  • 91.87 (a)
  • 93 (a)
(Mus musculus)
Mammalia Rbpms2 35
  • 88.01 (n)
  • 90.64 (a)
Rbpms2 16
Rbpms2 36
  • 87 (a)
(Pan troglodytes)
Mammalia RBPMS2 35
  • 99.04 (n)
  • 99.52 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rbpms2 35
  • 87.72 (n)
  • 89.47 (a)
(Bos Taurus)
Mammalia RBPMS2 36
  • 86 (a)
(Monodelphis domestica)
Mammalia RBPMS2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RBPMS2 36
  • 75 (a)
(Gallus gallus)
Aves RBPMS2 35
  • 81.67 (n)
  • 88.5 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia RBPMS2 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbpms2 35
  • 75.59 (n)
  • 85.86 (a)
Str.11196 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6280 35
(Danio rerio)
Actinopterygii rbpms2a 35
  • 76.63 (n)
  • 90.22 (a)
zgc55559 35
rbpms2a 36
  • 84 (a)
rbpms2b 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta cpo 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea mec-8 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9310 36
  • 24 (a)
Species with no ortholog for RBPMS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBPMS2 Gene

Gene Tree for RBPMS2 (if available)
Gene Tree for RBPMS2 (if available)

Paralogs for RBPMS2 Gene

Paralogs for RBPMS2 Gene

(1) SIMAP similar genes for RBPMS2 Gene using alignment to 2 proteins: Pseudogenes for RBPMS2 Gene

genes like me logo Genes that share paralogs with RBPMS2: view

Variants for RBPMS2 Gene

Sequence variations from dbSNP and Humsavar for RBPMS2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs5813319 -- 64,774,639(+) ACAAT(-/TTAA)TTAGT intron-variant
rs5813320 -- 64,765,603(-) CCCCC(-/C)GCCCT intron-variant
rs5813321 -- 64,765,590(-) GCCCT(-/T)TTTTT intron-variant
rs6494489 -- 64,741,112(+) AACTA(C/T)GGCCC intron-variant
rs6494490 -- 64,743,144(+) AGGAA(A/G)TCCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBPMS2 Gene

Variant ID Type Subtype PubMed ID
dgv31n68 CNV Loss 17160897
nsv528510 CNV Loss 19592680
nsv904307 CNV Loss 21882294

Variation tolerance for RBPMS2 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RBPMS2 Gene

Disorders for RBPMS2 Gene

Relevant External Links for RBPMS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RBPMS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBPMS2 Gene

Publications for RBPMS2 Gene

  1. Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. (PMID: 25064856) Sagnol S. … de Santa Barbara P. (Nucleic Acids Res. 2014) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors. (PMID: 23295309) Hapkova I. … de Santa Barbara P. (Exp. Mol. Pathol. 2013) 3
  4. The RNA-binding protein RBPMS2 regulates development of gastrointestinal smooth muscle. (PMID: 22683258) Notarnicola C. … De Santa Barbara P. (Gastroenterology 2012) 3
  5. A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. (PMID: 17986458) Bex C. … Buchberger A. (Nucleic Acids Res. 2007) 3

Products for RBPMS2 Gene

Sources for RBPMS2 Gene