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Aliases for RBPMS2 Gene

Aliases for RBPMS2 Gene

  • RNA Binding Protein With Multiple Splicing 2 2 3 5

External Ids for RBPMS2 Gene

Previous GeneCards Identifiers for RBPMS2 Gene

  • GC15M062612
  • GC15U900325
  • GC15M062747
  • GC15M062819
  • GC15M065032
  • GC15M041857

Summaries for RBPMS2 Gene

Entrez Gene Summary for RBPMS2 Gene

  • The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]

GeneCards Summary for RBPMS2 Gene

RBPMS2 (RNA Binding Protein With Multiple Splicing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBPMS.

UniProtKB/Swiss-Prot for RBPMS2 Gene

  • Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation.

Additional gene information for RBPMS2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBPMS2 Gene

Genomics for RBPMS2 Gene

Regulatory Elements for RBPMS2 Gene

Enhancers for RBPMS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H064805 1.4 Ensembl ENCODE dbSUPER 38.1 -33.7 -33703 6 RB1 ARNT ZSCAN4 BATF RAD21 ETS1 ZNF143 ATF7 RUNX3 IKZF2 RBPMS2 TRIP4 ANKDD1A PIF1
GH15H064632 1.5 Ensembl ENCODE dbSUPER 34.6 +140.5 140453 5 PKNOX1 FOXA2 DMAP1 YBX1 ZNF121 ZNF143 ZNF207 ATF7 RUNX3 JUNB RBPMS2 TRIP4 SLC24A1 RNU6-549P ZNF609 ENSG00000249240 PLEKHO2 SNX1 ENSG00000239465 LOC101930091
GH15H064772 1.3 Ensembl ENCODE dbSUPER 39.6 +0.9 874 5 GTF2E2 SIN3A E2F1 ZFHX2 CTBP1 EGR1 ZBTB48 POLR2A E2F6 ZBTB20 RBPMS2 TRIP4 MIR1272
GH15H064801 1 Ensembl ENCODE 49.6 -26.7 -26723 1 PKNOX1 ATF1 TCF12 ZNF121 POLR2A ZNF600 ATF7 RCOR1 CREM NFIA RBPMS2 TRIP4 PIF1 MIR1272
GH15H064638 1.7 FANTOM5 Ensembl ENCODE dbSUPER 27.4 +133.9 133907 6 ELF3 TBP FOXA2 MLX ARID4B ZSCAN9 RAD21 RARA ZNF121 RCOR1 RBPMS2 TRIP4 PLEKHO2 RNU6-549P ENSG00000249240 ENSG00000252774 SNX22 LOC101930091 GC15P068103
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBPMS2 on UCSC Golden Path with GeneCards custom track

Promoters for RBPMS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077989 187 1601 CHD1 SIN3A ELF1 DPF2 E2F1 ZFHX2 CTBP1 ID3 ZFX E2F6

Genomic Location for RBPMS2 Gene

Chromosome:
15
Start:
64,739,892 bp from pter
End:
64,775,587 bp from pter
Size:
35,696 bases
Orientation:
Minus strand

Genomic View for RBPMS2 Gene

Genes around RBPMS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBPMS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBPMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBPMS2 Gene

Proteins for RBPMS2 Gene

  • Protein details for RBPMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRY4-RBPS2_HUMAN
    Recommended name:
    RNA-binding protein with multiple splicing 2
    Protein Accession:
    Q6ZRY4
    Secondary Accessions:
    • A2RRG0

    Protein attributes for RBPMS2 Gene

    Size:
    209 amino acids
    Molecular mass:
    22497 Da
    Quaternary structure:
    • Homodimer. Interacts with EEF2.

    Three dimensional structures from OCA and Proteopedia for RBPMS2 Gene

    Alternative splice isoforms for RBPMS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBPMS2 Gene

Post-translational modifications for RBPMS2 Gene

  • Ubiquitination at Lys204
  • Modification sites at PhosphoSitePlus

Other Protein References for RBPMS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBPMS2 Gene

Domains & Families for RBPMS2 Gene

Gene Families for RBPMS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBPMS2 Gene

Suggested Antigen Peptide Sequences for RBPMS2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBPMS2: view

No data available for UniProtKB/Swiss-Prot for RBPMS2 Gene

Function for RBPMS2 Gene

Molecular function for RBPMS2 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation.

Phenotypes From GWAS Catalog for RBPMS2 Gene

Gene Ontology (GO) - Molecular Function for RBPMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IDA 25064856
GO:0005515 protein binding IPI 25064856
GO:0042803 protein homodimerization activity IPI,IEA 25064856
genes like me logo Genes that share ontologies with RBPMS2: view
genes like me logo Genes that share phenotypes with RBPMS2: view

Animal Model Products

CRISPR Products

miRNA for RBPMS2 Gene

miRTarBase miRNAs that target RBPMS2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBPMS2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBPMS2 Gene

Localization for RBPMS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBPMS2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBPMS2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBPMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25064856
genes like me logo Genes that share ontologies with RBPMS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RBPMS2 Gene

Pathways & Interactions for RBPMS2 Gene

SuperPathways for RBPMS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBPMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030514 negative regulation of BMP signaling pathway ISS --
GO:0048557 embryonic digestive tract morphogenesis ISS --
GO:0048661 positive regulation of smooth muscle cell proliferation ISS --
GO:0051151 negative regulation of smooth muscle cell differentiation ISS --
genes like me logo Genes that share ontologies with RBPMS2: view

No data available for Pathways by source and SIGNOR curated interactions for RBPMS2 Gene

Drugs & Compounds for RBPMS2 Gene

No Compound Related Data Available

Transcripts for RBPMS2 Gene

mRNA/cDNA for RBPMS2 Gene

Unigene Clusters for RBPMS2 Gene

RNA binding protein with multiple splicing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBPMS2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for RBPMS2 Gene

GeneLoc Exon Structure for
RBPMS2
ECgene alternative splicing isoforms for
RBPMS2

Expression for RBPMS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBPMS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBPMS2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x8.7), Heart - Left Ventricle (x8.1), Colon - Sigmoid (x4.7), Esophagus - Gastroesophageal Junction (x4.2), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for RBPMS2 Gene

This gene is overexpressed in Fetal heart (12.1), Peripheral blood mononuclear cells (10.4), Platelet (9.3), Colon (8.8), Urinary Bladder (8.1), Rectum (6.7), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBPMS2 Gene



Protein tissue co-expression partners for RBPMS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBPMS2 Gene:

RBPMS2

SOURCE GeneReport for Unigene cluster for RBPMS2 Gene:

Hs.436518

Evidence on tissue expression from TISSUES for RBPMS2 Gene

  • Muscle(2.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with RBPMS2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBPMS2 Gene

Orthologs for RBPMS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBPMS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBPMS2 33 34
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia RBPMS2 33 34
  • 89.63 (n)
oppossum
(Monodelphis domestica)
Mammalia RBPMS2 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbpms2 33 16 34
  • 88.01 (n)
rat
(Rattus norvegicus)
Mammalia Rbpms2 33
  • 87.72 (n)
cow
(Bos Taurus)
Mammalia RBPMS2 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBPMS2 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBPMS 34
  • 86 (a)
OneToOne
RBPMS2 33
  • 81.67 (n)
lizard
(Anolis carolinensis)
Reptilia RBPMS2 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbpms2 33
  • 75.59 (n)
Str.11196 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6280 33
zebrafish
(Danio rerio)
Actinopterygii rbpms2b 34
  • 80 (a)
OneToMany
rbpms2a 33 34
  • 76.63 (n)
zgc55559 33
fruit fly
(Drosophila melanogaster)
Insecta cpo 34
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mec-8 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9310 34
  • 24 (a)
OneToMany
Species where no ortholog for RBPMS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBPMS2 Gene

ENSEMBL:
Gene Tree for RBPMS2 (if available)
TreeFam:
Gene Tree for RBPMS2 (if available)

Paralogs for RBPMS2 Gene

Paralogs for RBPMS2 Gene

(1) SIMAP similar genes for RBPMS2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RBPMS2 Gene

genes like me logo Genes that share paralogs with RBPMS2: view

Variants for RBPMS2 Gene

Sequence variations from dbSNP and Humsavar for RBPMS2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000117598 -- 64,762,421(+) TGCAG(C/T)CTACA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000196643 -- 64,746,131(+) CAGTA(A/G)AACAA intron-variant
rs1000327835 -- 64,766,203(+) CAAGA(A/G)CCTCT intron-variant
rs1000392342 -- 64,751,116(+) GATCA(C/T)GAGGT intron-variant
rs1000402998 -- 64,742,648(+) GCGGG(A/G)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBPMS2 Gene

Variant ID Type Subtype PubMed ID
dgv1226n106 CNV deletion 24896259
dgv31n68 CNV loss 17160897
nsv1071215 CNV deletion 25765185
nsv528510 CNV loss 19592680
nsv569703 CNV loss 21841781

Variation tolerance for RBPMS2 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBPMS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBPMS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBPMS2 Gene

Disorders for RBPMS2 Gene

Relevant External Links for RBPMS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBPMS2

No disorders were found for RBPMS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBPMS2 Gene

Publications for RBPMS2 Gene

  1. Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. (PMID: 25064856) Sagnol S … de Santa Barbara P (Nucleic acids research 2014) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors. (PMID: 23295309) Hapkova I … de Santa Barbara P (Experimental and molecular pathology 2013) 3 60

Products for RBPMS2 Gene

Sources for RBPMS2 Gene

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