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Aliases for RBPMS2 Gene

Aliases for RBPMS2 Gene

  • RNA Binding Protein With Multiple Splicing 2 2 3

External Ids for RBPMS2 Gene

Previous GeneCards Identifiers for RBPMS2 Gene

  • GC15M062612
  • GC15U900325
  • GC15M062747
  • GC15M062819
  • GC15M065032
  • GC15M041857

Summaries for RBPMS2 Gene

GeneCards Summary for RBPMS2 Gene

RBPMS2 (RNA Binding Protein With Multiple Splicing 2) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and nucleic acid binding. An important paralog of this gene is RBPMS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBPMS2 Gene

Genomics for RBPMS2 Gene

Regulatory Elements for RBPMS2 Gene

Genomic Location for RBPMS2 Gene

Start:
64,739,892 bp from pter
End:
64,775,587 bp from pter
Size:
35,696 bases
Orientation:
Minus strand

Genomic View for RBPMS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBPMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBPMS2 Gene

Proteins for RBPMS2 Gene

  • Protein details for RBPMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRY4-RBPS2_HUMAN
    Recommended name:
    RNA-binding protein with multiple splicing 2
    Protein Accession:
    Q6ZRY4
    Secondary Accessions:
    • A2RRG0

    Protein attributes for RBPMS2 Gene

    Size:
    209 amino acids
    Molecular mass:
    22497 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBPMS2 Gene

    Alternative splice isoforms for RBPMS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBPMS2 Gene

Proteomics data for RBPMS2 Gene at MOPED

Post-translational modifications for RBPMS2 Gene

  • Ubiquitination at Lys204
  • Modification sites at PhosphoSitePlus

Other Protein References for RBPMS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBPMS2 Gene

Domains for RBPMS2 Gene

Gene Families for RBPMS2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBPMS2 Gene

Suggested Antigen Peptide Sequences for RBPMS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZRY4

UniProtKB/Swiss-Prot:

RBPS2_HUMAN :
  • Q6ZRY4
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBPMS2: view

Function for RBPMS2 Gene

Gene Ontology (GO) - Molecular Function for RBPMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RBPMS2: view

Phenotypes for RBPMS2 Gene

GenomeRNAi human phenotypes for RBPMS2:
genes like me logo Genes that share phenotypes with RBPMS2: view

miRNA for RBPMS2 Gene

miRTarBase miRNAs that target RBPMS2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBPMS2 Gene

Localization for RBPMS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBPMS2 Gene COMPARTMENTS Subcellular localization image for RBPMS2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBPMS2 Gene

Pathways for RBPMS2 Gene

SuperPathways for RBPMS2 Gene

No Data Available

Interacting Proteins for RBPMS2 Gene

Gene Ontology (GO) - Biological Process for RBPMS2 Gene

None

No data available for Pathways by source for RBPMS2 Gene

Transcripts for RBPMS2 Gene

mRNA/cDNA for RBPMS2 Gene

Unigene Clusters for RBPMS2 Gene

RNA binding protein with multiple splicing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for RBPMS2 Gene

GeneLoc Exon Structure for
RBPMS2
ECgene alternative splicing isoforms for
RBPMS2

Expression for RBPMS2 Gene

mRNA expression in normal human tissues for RBPMS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBPMS2 Gene

This gene is overexpressed in Heart - Atrial Appendage (8.7), Heart - Left Ventricle (8.1), Colon - Sigmoid (4.7), Esophagus - Gastroesophageal Junction (4.2), and Artery - Tibial (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RBPMS2 Gene

SOURCE GeneReport for Unigene cluster for RBPMS2 Gene Hs.436518

genes like me logo Genes that share expressions with RBPMS2: view

No data available for mRNA Expression by UniProt/SwissProt for RBPMS2 Gene

Orthologs for RBPMS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBPMS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBPMS2 35
  • 99.04 (n)
  • 99.52 (a)
RBPMS2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBPMS2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBPMS2 35
  • 89.63 (n)
  • 91.87 (a)
RBPMS2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbpms2 35
  • 88.01 (n)
  • 90.64 (a)
Rbpms2 16
Rbpms2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBPMS2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBPMS2 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbpms2 35
  • 87.72 (n)
  • 89.47 (a)
chicken
(Gallus gallus)
Aves RBPMS 36
  • 86 (a)
OneToOne
RBPMS2 35
  • 81.67 (n)
  • 88.5 (a)
lizard
(Anolis carolinensis)
Reptilia RBPMS2 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6280 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbpms2 35
  • 75.59 (n)
  • 85.86 (a)
Str.11196 35
zebrafish
(Danio rerio)
Actinopterygii rbpms2a 35
  • 76.63 (n)
  • 90.22 (a)
rbpms2a 36
  • 84 (a)
OneToMany
rbpms2b 36
  • 80 (a)
OneToMany
zgc55559 35
fruit fly
(Drosophila melanogaster)
Insecta cpo 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mec-8 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9310 36
  • 24 (a)
OneToMany
Species with no ortholog for RBPMS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBPMS2 Gene

ENSEMBL:
Gene Tree for RBPMS2 (if available)
TreeFam:
Gene Tree for RBPMS2 (if available)

Paralogs for RBPMS2 Gene

Paralogs for RBPMS2 Gene

Selected SIMAP similar genes for RBPMS2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RBPMS2 Gene

genes like me logo Genes that share paralogs with RBPMS2: view

Variants for RBPMS2 Gene

Sequence variations from dbSNP and Humsavar for RBPMS2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs951721 -- 64,752,236(+) TTAAT(C/T)CATTG intron-variant
rs953764 -- 64,759,090(+) ccATC(C/T)TGAGC intron-variant
rs1008917 -- 64,767,452(+) AGTTC(C/T)GGGTA intron-variant
rs1385950 -- 64,758,991(+) tcact(C/T)tgtgg intron-variant
rs1976112 -- 64,767,021(+) tcaag(A/T)gatcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBPMS2 Gene

Variant ID Type Subtype PubMed ID
dgv31n68 CNV Loss 17160897
nsv528510 CNV Loss 19592680
nsv904307 CNV Loss 21882294

Relevant External Links for RBPMS2 Gene

HapMap Linkage Disequilibrium report
RBPMS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBPMS2 Gene

Disorders for RBPMS2 Gene

No disorders were found for RBPMS2 Gene.

No data available for UniProtKB/Swiss-Prot for RBPMS2 Gene

Publications for RBPMS2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. (PMID: 25064856) Sagnol S. … de Santa Barbara P. (Nucleic Acids Res. 2014) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4

Products for RBPMS2 Gene

Sources for RBPMS2 Gene

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