Aliases for RBPMS Gene
External Ids for RBPMS Gene
Previous GeneCards Identifiers for RBPMS Gene
This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
GeneCards Summary for RBPMS Gene
RBPMS (RNA Binding Protein With Multiple Splicing) is a Protein Coding gene. Diseases associated with RBPMS include Colon Carcinoma In Situ. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBPMS2.
UniProtKB/Swiss-Prot for RBPMS Gene
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).