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RBPMS Gene

protein-coding   GIFtS: 60
GCID: GC08P030242

RNA Binding Protein With Multiple Splicing

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Protein With Multiple Splicing1 2
Heart And RRM Expressed Sequence2 3
HERMES2 3
RNA-Binding Protein With Multiple Splicing2
Hermes3
RBP-MS3

External Ids:    HGNC: 190971   Entrez Gene: 110302   Ensembl: ENSG000001571107   OMIM: 6015585   UniProtKB: Q930623   

Export aliases for RBPMS gene to outside databases

Previous GC identifers: GC08P030157 GC08P030693 GC08P030299 GC08P030361 GC08P028786


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBPMS Gene:
This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif
is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA
recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved
hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Jun 2013)

GeneCards Summary for RBPMS Gene:
RBPMS (RNA binding protein with multiple splicing) is a protein-coding gene. Diseases associated with RBPMS include ataxia, and hepatocellular carcinoma. GO annotations related to this gene include poly(A) binding and nucleotide binding. An important paralog of this gene is RBPMS2.

UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062
Function: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated
transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases
phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1.
Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA

Gene Wiki entry for RBPMS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBPMS gene promoter:
         Max1   FOXF2   ATF-2   FOXD1   IRF-1   C/EBPalpha   CRE-BP1   COMP1   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBPMS promoter sequence
   Search Chromatin IP Primers for RBPMS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBPMS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

RBPMS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBPMS gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P030242:  view genomic region     (about GC identifiers)

Start:
30,241,944 bp from pter      End:
30,429,778 bp from pter
Size:
187,835 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062 (See protein sequence)
Recommended Name: RNA-binding protein with multiple splicing  
Size: 196 amino acids; 21802 Da
Subunit: Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct
1 PDB 3D structure from and Proteopedia for RBPMS:
1BNY (3D)    
Secondary accessions: D3DSU9 Q92516 Q92517 Q92518 Q96J26
Alternative splicing: 5 isoforms:  Q93062-1   Q93062-2   Q93062-3   Q93062-4   Q93062-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RBPMS: NX_Q93062

Explore proteomics data for RBPMS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBPMS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001008710.1  NP_001008711.1  NP_001008712.1  NP_006858.1  

    ENSEMBL proteins: 
     ENSP00000380486   ENSP00000340176   ENSP00000318102   ENSP00000287771   ENSP00000428675  
     ENSP00000427896   ENSP00000429086   ENSP00000430342   ENSP00000430638   ENSP00000430370  
     ENSP00000430893   ENSP00000445406  

    RBPMS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for RBPMS
    OriGene Custom MassSpec
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    Novus Biologicals RBPMS Protein
    Novus Biologicals RBPMS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RBPMS

    RBPMS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals RBPMS Antibodies
    Abcam antibodies for RBPMS
    Cloud-Clone Corp. Antibodies for RBPMS
    ThermoFisher Antibody for RBPMS
    LSBio Antibodies in human, mouse, rat for RBPMS

    RBPMS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RBPMS
    Cloud-Clone Corp. CLIAs for RBPMS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q93062

    ProtoNet protein and cluster: Q93062

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062
    Domain: The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are
    required for TGFB1/Smad-mediated transactivation activity
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    RBPMS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBPMS_HUMAN, Q93062
    Function: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated
    transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases
    phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1.
    Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA

         Genatlas biochemistry entry for RBPMS:
    RNA binding protein gene with multiple transcripts,types 1,2,3,4,5

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003713transcription coactivator activity IDA17099224
    GO:0005515protein binding IPI16189514
    GO:0008143poly(A) binding IDA17099224
         
    RBPMS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RBPMS:
     Decreased viability with carbo 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBPMS
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBPMS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RBPMS

    miRNA
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    miRTarBase miRNAs that target RBPMS:
    hsa-mir-98-5p (MIRT027579), hsa-mir-124-3p (MIRT022396)

    Block miRNA regulation of human, mouse, rat RBPMS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBPMS (see all 46):
    hsa-miR-576-3p hsa-miR-640 hsa-miR-4328 hsa-miR-548k hsa-let-7a-2* hsa-miR-219-5p hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidRBPMS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RBPMS
    Predesigned siRNA for gene silencing in human, mouse, rat RBPMS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RBPMS

    Clone
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    OriGene clones in human, mouse for RBPMS (see all 24)
    OriGene ORF clones in mouse, rat for RBPMS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RBPMS (NM_001008711)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBPMS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBPMS

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    Browse ESI BIO Cell Lines and PureStem Progenitors for RBPMS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBPMS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBPMS_HUMAN, Q93062: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    RBPMS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RBPMS About    
    See pathways by source

    SuperPathContained pathways About
    1Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    1 BioSystems Pathway for RBPMS
        Diurnally regulated genes with circadian orthologs


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBPMS
    Interactions:

        Search GeneGlobe Interaction Network for RBPMS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBPMS (Q930621, 2, 3 ENSP000003401764) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP9Q9BRR92, 3, ENSP000003773804MINT-67740 I2D: score=5 STRING: ENSP00000377380
    CCNKO759092, 3, ENSP000003745294MINT-66934 I2D: score=5 STRING: ENSP00000374529
    CDC23Q9UJX22, 3, ENSP000003783504MINT-66993 I2D: score=5 STRING: ENSP00000378350
    CDC42EP1Q005872, 3, ENSP000002490144MINT-66453 I2D: score=5 STRING: ENSP00000249014
    CNNM3Q8NE012, 3, ENSP000003054494MINT-68099 I2D: score=5 STRING: ENSP00000305449
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006396RNA processing TAS8855282
    GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation IDA17099224
    GO:0060391positive regulation of SMAD protein import into nucleus IDA17099224

    RBPMS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBPMS



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RBPMS gene (4 alternative transcripts): 
    NM_001008710.2  NM_001008711.2  NM_001008712.2  NM_006867.3  

    Unigene Cluster for RBPMS:

    RNA binding protein with multiple splicing
    Hs.334587  [show with all ESTs]
    Unigene Representative Sequence: AK124859
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000397323(uc003xie.1 uc003xif.1) ENST00000339877(uc003xib.3)
    ENST00000320203(uc003xic.1) ENST00000287771(uc003xid.1) ENST00000517860
    ENST00000520161 ENST00000523115 ENST00000519647 ENST00000521816 ENST00000520191(uc011lba.1 uc010lvh.1)
    ENST00000523717 ENST00000522708 ENST00000519359 ENST00000522694 ENST00000522099
    ENST00000521370 ENST00000523104 ENST00000519657
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RBPMS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBPMS (see all 46):
    hsa-miR-576-3p hsa-miR-640 hsa-miR-4328 hsa-miR-548k hsa-let-7a-2* hsa-miR-219-5p hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidRBPMS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RBPMS
    Predesigned siRNA for gene silencing in human, mouse, rat RBPMS
    Clone
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    OriGene clones in human, mouse for RBPMS (see all 24)
    OriGene ORF clones in mouse, rat for RBPMS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RBPMS (NM_001008711)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBPMS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBPMS
    Primer
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    OriGene qPCR primer pairs and template standards for RBPMS
    OriGene qSTAR qPCR primer pairs in human, mouse for RBPMS
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RBPMS
      QuantiTect SYBR Green Assays in human, mouse, rat RBPMS
      QuantiFast Probe-based Assays in human, mouse, rat RBPMS

    Additional mRNA sequence: 

    AK024192.1 AK057533.1 AK098281.1 AK124859.1 AK304858.1 AK310533.1 BC003608.2 BC063494.1 
    BC092476.1 D84107.1 D84108.1 D84109.1 D84110.1 D84111.1 

    Selected DOTS entries (see all 35):

    DT.452680  DT.40262559  DT.417251  DT.95178092  DT.95205256  DT.91742476  DT.91746239  DT.121479893 
    DT.100813609  DT.404700  DT.121480036  DT.87015998  DT.97785515  DT.100813618  DT.121479972  DT.427666 
    DT.40254643  DT.95205261  DT.91697978  DT.95117452  DT.121479999  DT.95205254  DT.95205266  DT.95233473 

    Selected AceView cDNA sequences (see all 264):

    BM672706 AI339365 AA480108 BM931928 H43390 AW375377 BM127635 CB045455 
    AW375378 AI417896 AI052630 BM663438 CD172092 AA903369 BQ898847 BM710149 
    AI918538 CR613046 AI685233 AA481920 AW375382 BE744630 BP342849 BM849091 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                    -                                         -                 -     -     -     -           -           -     -                     
    SP2:                    -                                         -                 -     -     -     -     -     -                 -                     
    SP3:                    -                                         -                 -     -     -     -     -     -           -     -                     
    SP4:                    -                                         -                 -     -                                                               
    SP5:                    -                                         -                                                                                       


    ECgene alternative splicing isoforms for RBPMS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBPMS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAATTTGT
    RBPMS Expression
    About this image


    RBPMS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
    RBPMS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBPMS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334587

    UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062
    Tissue specificity: Ubiquitously expressed, at various levels depending on the isoform and the tissue

        Custom PCR Arrays for RBPMS
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    QuantiTect SYBR Green Assays in human, mouse, rat RBPMS
    QuantiFast Probe-based Assays in human, mouse, rat RBPMS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBPMS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RBPMS gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbpms1 , 5 RNA binding protein gene with multiple splicing1, 5 94.98(n)1
    99.54(a)1
      8 (20.85 cM)5
    196631  NM_001042675.21  NP_001036140.11 
     337826435 
    chicken
    (Gallus gallus)
    Aves RBPMS1 RNA binding protein with multiple splicing 79.19(n)
    89.6(a)
      428738  XM_426296.4  XP_426296.4 
    lizard
    (Anolis carolinensis)
    Reptilia RBPMS6
    RNA binding protein with multiple splicing
    84(a)
    1 ↔ 1
    GL343257.1(591857-686011)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060391.12   -- 82.08(n)    BC060391.1 
    zebrafish
    (Danio rerio)
    Actinopterygii RBPMS6
    RNA binding protein with multiple splicing
    63(a)
    1 ↔ 1
    7(77053840-77060138) ENSDARG00000088558
    fruit fly
    (Drosophila melanogaster)
    Insecta cpo3 peripheral nervous system development
    RNA binding
    66(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea mec-86
    Protein MEC-8 (mec-8) mRNA, complete cds
    25(a)
    1 → many
    I(9441014-9450731) WBGene00003172


    ENSEMBL Gene Tree for RBPMS (if available)
    TreeFam Gene Tree for RBPMS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBPMS gene
    RBPMS22  
    1 SIMAP similar gene for RBPMS using alignment to 9 protein entries:     RBPMS_HUMAN (see all proteins):
    RBPMS2

    RBPMS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBPMS (see all 3959)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105441921,2
    C--28849240(+) tgtgt-/GC    
       
    /GCGC
    GCGCG
    4 -- int11NA 2
    rs1442380071,2
    C--28888753(+) AACAT-/AA    
       AAAAA
    AAACA
    4 -- int10--------
    rs29156231,2
    C,F--28921832(+) TCTCTC/TTTTTT 4 -- int1 trp32Minor allele frequency- T:0.50WA CSA 4
    rs359096251,2
    C--28931252(+) TTTTT-/TGGTAT 4 -- int10--------
    rs1117266371,2
    C--28941680(+) TTTTTT/-GAGAC 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs795609081,2
    C--28964762(+) ACAGA-/TAGACG 3 -- int10--------
    rs350443141,2
    C--30250911(+) GTGAG-/TTTTTT 4 -- int10--------
    rs558616961,2
    C--30251955(+) GGAGG-/CCCCCC 4 -- int12Minor allele frequency- C:0.25NA 4
    rs361247351,2
    C--30254149(+) ATTGA-/TTTGGA 4 -- int10--------
    rs712817351,2
    C--30256801(-) CCTTG-/AAAAAA 4 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for RBPMS (30241944 - 30429778 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RBPMS (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736831CNV Deletion23290073
    esv988355CNV Deletion20482838
    esv2657168CNV Deletion23128226
    esv2367432CNV Deletion18987734
    esv1086519CNV Deletion17803354
    esv4813CNV Deletion18987735
    esv2585826CNV Deletion19546169
    nsv509260CNV Insertion20534489
    nsv528908CNV Loss19592680
    esv6638CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBPMS
    DNA2.0 Custom Variant and Variant Library Synthesis for RBPMS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601558    OMIM disorders: --

    2 diseases for RBPMS:    
    About MalaCards
    ataxia    hepatocellular carcinoma


    RBPMS for disorders           About GeneDecksing

    Genetic Association Database (GAD): RBPMS
    Human Genome Epidemiology (HuGE) Navigator: RBPMS (1 document)

    Export disorders for RBPMS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBPMS gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with RBPMS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs. (PubMed id 8855282)1, 2, 3, 9 Shimamoto A.... Furuichi Y. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs. (PubMed id 22174390)1, 4 Rankinen T....Bouchard C. (J. Appl. Physiol. 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Potentiation of Smad-mediated transcriptional activation by the RNA- binding protein RBPMS. (PubMed id 17099224)1, 2 Sun Y.... Ye Q. (Nucleic Acids Res. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    7. Protein interactions of the transcription factor Hoxa1. (PubMed id 23088713)1 Lambert B....Rezsohazy R. (BMC Dev. Biol. 2012)
    8. The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1. (PubMed id 22234250)1 Lai Y....Shiio Y. (Arch. Biochem. Biophys. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11030 HGNC: 19097 AceView: RBPMS Ensembl:ENSG00000157110 euGenes: HUgn11030
    ECgene: RBPMS H-InvDB: RBPMS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RBPMS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBPMS gene:
    Search GeneIP for patents involving RBPMS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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