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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBPMS Gene

protein-coding   GIFtS: 56
GCID: GC08P030242

RNA binding protein with multiple splicing
 Explore 4 diseases affiliated with
RBPMS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RBPMS    

Aliases
for RBPMS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RNA Binding Protein With Multiple Splicing1 2
HERMES1 2 3
Heart And RRM Expressed Sequence2 3
RBP-MS2 3
RNA-Binding Protein With Multiple Splicing2
Hermes3

External Ids:    HGNC: 190971   Entrez Gene: 110302   Ensembl: ENSG000001571107   OMIM: 6015585   UniProtKB: Q930623   

Export aliases for RBPMS gene to outside databases

Previous GC identifers: GC08P030157 GC08P030693 GC08P030299 GC08P030361 GC08P028786


Summaries
for RBPMS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RBPMS:
This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in
length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of
conserved sequence called RNP1 and RNP2, as well as a few highly conserved hydrophobic residues. The protein encoded
by this gene has a single, putative RRM domain in its N-terminus. Alternative splicing results in multiple transcript
variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062
Function: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation.
Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3
on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2,
SMAD3 and SMAD4 proteins. Binds to poly(A) RNA

Gene Wiki entry for RBPMS


Genomic Views
for RBPMS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBPMS gene promoter:
         Max1   FOXF2   ATF-2   FOXD1   IRF-1   C/EBPalpha   CRE-BP1   COMP1   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RBPMS promoter sequence
   Search SABiosciences Chromatin IP Primers for RBPMS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBPMS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

RBPMS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBPMS gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P030242:  view genomic region     (about GC identifiers)

Start:
 30,241,944 bp from pter      End:
 30,429,778 bp from pter
Size:
 187,835 bases      Orientation:
 plus strand

Proteins
for RBPMS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062 (See protein sequence)
Recommended Name: RNA-binding protein with multiple splicing  
Size: 196 amino acids; 21802 Da
Subunit: Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct
Subcellular location: Nucleus. Cytoplasm
1 PDB 3D structure from and Proteopedia for RBPMS:
1BNY (3D)    
Secondary accessions: D3DSU9 Q92516 Q92517 Q92518 Q96J26
Alternative splicing: 5 isoforms:  Q93062-1   Q93062-2   Q93062-3   Q93062-4   Q93062-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RBPMS: NX_Q93062

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q93062

    • RBPMS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001008710.1  NP_001008711.1  NP_001008712.1  NP_006858.1  

    ENSEMBL proteins: 
     ENSP00000380486   ENSP00000340176   ENSP00000318102   ENSP00000287771   ENSP00000428675  
     ENSP00000427896   ENSP00000429086   ENSP00000430342   ENSP00000430638   ENSP00000430370  
     ENSP00000430893   ENSP00000445406  

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    Novus Biologicals RBPMS Protein
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RBPMS

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    RBPMS for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RBPMS

    Protein Domains /
    Families
    for RBPMS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RBPMS for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q93062

    ProtoNet protein and cluster: Q93062

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062
    Domain: The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for
    TGFB1/Smad-mediated transactivation activity
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Function
    for RBPMS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062
    Function: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation.
    Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3
    on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2,
    SMAD3 and SMAD4 proteins. Binds to poly(A) RNA

         Genatlas biochemistry entry for RBPMS:
    RNA binding protein gene with multiple transcripts,types 1,2,3,4,5

    miRNA
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    hsa-miR-576-3p hsa-miR-640 hsa-miR-4328 hsa-miR-548k hsa-let-7a-2* hsa-miR-219-5p hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: RBPMS 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003713transcription coactivator activity IDA17099224
    GO:0005515protein binding IPI--
    GO:0008143poly(A) RNA binding IDA17099224


    RBPMS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RBPMS:
     Decreased viability with carbo 


    Pathways & Interactions
    for RBPMS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Diurnally regulated genes with circadian orthologs
    		Diurnally regulated genes with circadian orthologs1.00


    1 BioSystems Pathway for RBPMS 
        Diurnally regulated genes with circadian orthologs


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBPMS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for RBPMS (Q930621, 2, 3 ENSP000003401764) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP9Q9BRR92, 3, ENSP000003773804MINT-67740 I2D: score=5 STRING: ENSP00000377380
    CCNKO759092, 3, ENSP000003745294MINT-66934 I2D: score=5 STRING: ENSP00000374529
    CDC23Q9UJX22, 3, ENSP000003783504MINT-66993 I2D: score=5 STRING: ENSP00000378350
    CDC42EP1Q005872, 3, ENSP000002490144MINT-66453 I2D: score=5 STRING: ENSP00000249014
    CNNM3Q8NE012, 3, ENSP000003054494MINT-68099 I2D: score=5 STRING: ENSP00000305449
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006396RNA processing TAS8855282
    GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation IDA17099224
    GO:0060391positive regulation of SMAD protein import into nucleus IDA17099224


    RBPMS for ontologies           About GeneDecksing



    Drugs & Compounds
    for RBPMS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBPMS
    Search CenterWatch for drugs/clinical trials and news about RBPMS 

    Transcripts
    for RBPMS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RBPMS gene (4 alternative transcripts): 
    NM_001008710.1  NM_001008711.1  NM_001008712.1  NM_006867.2  

    Unigene Cluster for RBPMS:

    RNA binding protein with multiple splicing
    Hs.334587  [show with all ESTs]
    Unigene Representative Sequence: AK124859
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000397323(uc003xie.1 uc003xif.1) ENST00000339877(uc003xib.3)
    ENST00000320203(uc003xic.1) ENST00000287771(uc003xid.1) ENST00000517860
    ENST00000520161 ENST00000523115 ENST00000519647 ENST00000521816 ENST00000520191(uc011lba.1 uc010lvh.1)
    ENST00000523717 ENST00000522708 ENST00000519359 ENST00000522694 ENST00000522099
    ENST00000521370 ENST00000523104 ENST00000519657

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate RBPMS (see all 46):
    hsa-miR-576-3p hsa-miR-640 hsa-miR-4328 hsa-miR-548k hsa-let-7a-2* hsa-miR-219-5p hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: RBPMS 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK024192.1 AK057533.1 AK098281.1 AK124859.1 AK304858.1 AK310533.1 BC003608.2 BC063494.1 
    BC092476.1 D84107.1 D84108.1 D84109.1 D84110.1 D84111.1 

    24/35 DOTS entries (see all 35):

    DT.452680  DT.40262559  DT.417251  DT.95178092  DT.95205256  DT.91742476  DT.91746239  DT.121479893 
    DT.100813609  DT.404700  DT.121480036  DT.87015998  DT.97785515  DT.100813618  DT.121479972  DT.427666 
    DT.40254643  DT.95205261  DT.91697978  DT.95117452  DT.121479999  DT.95205254  DT.95205266  DT.95233473 

    24/264 AceView cDNA sequences (see all 264):

    BQ878081 BM663438 BM849091 AW029261 BF939618 BX390382 AI804996 AI685233 
    BG163526 BX952240 BM672706 C01134 BG696755 BQ960665 AA424218 CA425568 
    BP342849 AA481920 AI339365 BG057790 BU731541 AW375382 AW375378 AW375377 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                    -                                         -                 -     -     -     -           -           -     -                     
    SP2:                    -                                         -                 -     -     -     -     -     -                 -                     
    SP3:                    -                                         -                 -     -     -     -     -     -           -     -                     
    SP4:                    -                                         -                 -     -                                                               
    SP5:                    -                                         -                                                                                       


    ECgene alternative splicing isoforms for RBPMS

    Expression
    for RBPMS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBPMS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAATTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RBPMS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBPMS

    SOURCE GeneReport for Unigene cluster: Hs.334587

    UniProtKB/Swiss-Prot: RBPMS_HUMAN, Q93062
    Tissue specificity: Ubiquitously expressed, at various levels depending on the isoform and the tissue

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    In Situ
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    Orthologs
    for RBPMS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBPMS gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rbpms1 , 5 RNA binding protein gene with multiple splicing1, 5 94.98(n)1
    99.54(a)1    		   8 (20.85 cM)5
    196631  NM_001042675.11  NP_001036140.11 
     337826445 
    chicken
    (Gallus gallus)    		 Aves RBPMS1 RNA binding protein with multiple splicing 82.91(n)
    96.2(a)    		   428738  XM_426296.3  XP_426296.3 
    lizard
    (Anolis carolinensis)    		 Reptilia RBPMS6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343257.1(615527-644492)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC060391.12   -- 82.08(n)    BC060391.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01079823.16
    		 --
    		 63(a)
    		 1 ↔ 1
    		 7(77053840-77060138)
    fruit fly
    (Drosophila melanogaster)    		 Insecta cpo3 peripheral nervous system development RNA
    binding    		 66(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mec-86
    		 MEChanosensory abnormality family member (mec-8)
    		 26(a)
    		 1 → many
    		 I(9441007-9450724)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G422406
    AT3G137006
    (see all 3)    		 RNA recognition motif-containing protein
    (see all 3)    		 17(a)
    16(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2(17596817-17599604)
    3(4490628-4493737)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 proline rich protein 3, putative, expressed
    (see all 3)    		 16(a)
    15(a)
    (see all 3)    		 many ↔ many
    possible ortholog
    (see all 3)    		 6(2634899-2640380)
    8(9122564-9126613)


    ENSEMBL Gene Tree for RBPMS (if available)
    TreeFam Gene Tree for RBPMS (if available) 

    Paralogs
    for RBPMS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RBPMS gene
    RBPMS22  
    1 SIMAP similar gene for RBPMS using alignment to 9 protein entries:     RBPMS_HUMAN (see all proteins):
    RBPMS2

    RBPMS for paralogs           About GeneDecksing



    Genomic Variants
    for RBPMS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3317 NCBI SNPs in RBPMS are shown (see all 3317)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs753989721,2
    		C,F,--28784676(+) TTCCTG/TTTTCA 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs794275651,2
    		F,--28784996(+) AGGGAG/CGGTCC 4 -- us2k11Minor allele frequency- C:0.04WA 118
    rs732410251,2
    		C,--28785064(+) ATAAAC/GAATGT 4 -- us2k10--------
    rs1156262001,2
    		C,F,--28785627(+) GCCCAG/AGCCCC 4 -- us2k11Minor allele frequency- A:0.26WA 118
    rs1131986781,2
    		C,--28786098(+) TAGGGC/TCAGGG 4 -- us2k12Minor allele frequency- T:0.05NA 122
    rs1166262001,2
    		C,F,--28787459(+) GACTTA/GGGGCC 4 -- int11Minor allele frequency- G:0.02WA 118
    rs797610891,2
    		--28788878(+) TCATAA/CCCACA 4 -- int10--------
    rs752145101,2
    		C,F,--28789458(+) ACTGAC/ACCTTT 4 -- int11Minor allele frequency- A:0.04WA 118
    rs747089571,2
    		C,F,--28791944(+) AGTGAC/AAATTC 4 -- int11Minor allele frequency- A:0.04NA 120
    rs1178064361,2
    		C,F,--28792753(+) GGTACT/CCCACA 4 -- int11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for RBPMS (30241944 - 30429778 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for RBPMS
         1 CNV: 100308
         6 Indels: 47527 41075 28908 13046 42042 62789

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBPMS
    DNA2.0 Custom Variant and Variant Library Synthesis for RBPMS

    Disorders / Diseases
    for RBPMS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RBPMS for disorders           About GeneDecksing

    OMIM gene information: 601558    OMIM disorders: --

    4 diseases for RBPMS:    About MalaCards
    hepatocellular carcinoma    ataxia    carcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: RBPMS (1 document)

    Export disorders for RBPMS gene to outside databases

    Publications
    for RBPMS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBPMS gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with RBPMS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs. (PubMed id 8855282)1, 2, 3, 9 Shimamoto A.... Furuichi Y. (1996)
    2. Potentiation of Smad-mediated transcriptional activation by the RNA- binding protein RBPMS. (PubMed id 17099224)1, 2 Sun Y.... Ye Q. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. Heritability of submaximal exercise heart rate respons e to exercise training is accounted for by nine SNPs. (PubMed id 22174390)1 Rankinen T....Bouchard C. (2012)
    6. The interaction of the von Hippel-Lindau tumor suppres sor and heterochromatin protein 1. (PubMed id 22234250)1 Lai Y....Shiio Y. (2012)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    External Searches for RBPMS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RBPMS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11030 HGNC: 19097 AceView: RBPMS Ensembl:ENSG00000157110 euGenes: HUgn11030
    ECgene: RBPMS H-InvDB: RBPMS

    Other Databases showing RBPMS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RBPMS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBPMS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RBPMS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RBPMS gene:
    Search GeneIP for patents involving RBPMS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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