Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBPMS Gene

Aliases for RBPMS Gene

  • RNA Binding Protein With Multiple Splicing 2 3
  • Heart And RRM Expressed Sequence 3 4
  • HERMES 3 4
  • RNA-Binding Protein With Multiple Splicing 3
  • RBP-MS 4

External Ids for RBPMS Gene

Previous GeneCards Identifiers for RBPMS Gene

  • GC08P030157
  • GC08P030693
  • GC08P030299
  • GC08P030242
  • GC08P028786

Summaries for RBPMS Gene

Entrez Gene Summary for RBPMS Gene

  • This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

GeneCards Summary for RBPMS Gene

RBPMS (RNA Binding Protein With Multiple Splicing) is a Protein Coding gene. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include nucleotide binding and poly(A) binding. An important paralog of this gene is RBPMS2.

UniProtKB/Swiss-Prot for RBPMS Gene

  • Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.

Gene Wiki entry for RBPMS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBPMS Gene

Genomics for RBPMS Gene

Regulatory Elements for RBPMS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBPMS Gene

Start:
30,384,479 bp from pter
End:
30,572,261 bp from pter
Size:
187,783 bases
Orientation:
Plus strand

Genomic View for RBPMS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBPMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBPMS Gene

Proteins for RBPMS Gene

  • Protein details for RBPMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93062-RBPMS_HUMAN
    Recommended name:
    RNA-binding protein with multiple splicing
    Protein Accession:
    Q93062
    Secondary Accessions:
    • D3DSU9
    • Q92516
    • Q92517
    • Q92518
    • Q96J26

    Protein attributes for RBPMS Gene

    Size:
    196 amino acids
    Molecular mass:
    21802 Da
    Quaternary structure:
    • Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct.

    Three dimensional structures from OCA and Proteopedia for RBPMS Gene

    Alternative splice isoforms for RBPMS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBPMS Gene

Proteomics data for RBPMS Gene at MOPED

Post-translational modifications for RBPMS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBPMS Gene

Domains for RBPMS Gene

Gene Families for RBPMS Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBPMS Gene

Graphical View of Domain Structure for InterPro Entry

Q93062

UniProtKB/Swiss-Prot:

RBPMS_HUMAN :
  • Q93062
Domain:
  • The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBPMS: view

Function for RBPMS Gene

Molecular function for RBPMS Gene

GENATLAS Biochemistry: RNA binding protein gene with multiple transcripts,types 1,2,3,4,5
UniProtKB/Swiss-Prot Function: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.

Gene Ontology (GO) - Molecular Function for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003713 transcription coactivator activity IDA 17099224
GO:0005515 protein binding IPI 16189514
GO:0008143 poly(A) binding IDA 17099224
genes like me logo Genes that share ontologies with RBPMS: view

Phenotypes for RBPMS Gene

GenomeRNAi human phenotypes for RBPMS:
genes like me logo Genes that share phenotypes with RBPMS: view

Animal Model Products

CRISPR Products

miRNA for RBPMS Gene

miRTarBase miRNAs that target RBPMS

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBPMS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBPMS Gene

Localization for RBPMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBPMS Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBPMS Gene COMPARTMENTS Subcellular localization image for RBPMS gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RBPMS: view

Pathways for RBPMS Gene

genes like me logo Genes that share pathways with RBPMS: view

Pathways by source for RBPMS Gene

1 BioSystems pathway for RBPMS Gene

Gene Ontology (GO) - Biological Process for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing TAS 8855282
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA 17099224
GO:0060391 positive regulation of SMAD protein import into nucleus IDA 17099224
genes like me logo Genes that share ontologies with RBPMS: view

Transcripts for RBPMS Gene

Unigene Clusters for RBPMS Gene

RNA binding protein with multiple splicing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBPMS

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8: - -
SP9: - - - - -
SP10:
SP11: - - - - -
SP12: - -

Relevant External Links for RBPMS Gene

GeneLoc Exon Structure for
RBPMS
ECgene alternative splicing isoforms for
RBPMS

Expression for RBPMS Gene

mRNA expression in normal human tissues for RBPMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBPMS Gene

This gene is overexpressed in Artery - Tibial (4.4), Esophagus - Gastroesophageal Junction (4.3), and Esophagus - Muscularis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBPMS Gene

SOURCE GeneReport for Unigene cluster for RBPMS Gene Hs.334587

mRNA Expression by UniProt/SwissProt for RBPMS Gene

Q93062-RBPMS_HUMAN
Tissue specificity: Ubiquitously expressed, at various levels depending on the isoform and the tissue
genes like me logo Genes that share expressions with RBPMS: view

In Situ Assay Products

Orthologs for RBPMS Gene

This gene was present in the common ancestor of animals.

Orthologs for RBPMS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBPMS 35
  • 99.7 (n)
  • 100 (a)
RBPMS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBPMS 35
  • 96.35 (n)
  • 98.17 (a)
RBPMS 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBPMS 35
  • 97.87 (n)
  • 100 (a)
RBPMS 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbpms 35
  • 94.98 (n)
  • 99.54 (a)
Rbpms 16
Rbpms 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBPMS 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbpms 35
  • 95.28 (n)
  • 99.54 (a)
chicken
(Gallus gallus)
Aves RBPMS 35
  • 79.19 (n)
  • 89.6 (a)
RBPMS 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBPMS 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbpms 35
  • 80.95 (n)
  • 89.14 (a)
zebrafish
(Danio rerio)
Actinopterygii RBPMS 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cpo 36
  • 14 (a)
OneToMany
cpo 37
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea mec-8 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9310 36
  • 23 (a)
OneToMany
Species with no ortholog for RBPMS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBPMS Gene

ENSEMBL:
Gene Tree for RBPMS (if available)
TreeFam:
Gene Tree for RBPMS (if available)

Paralogs for RBPMS Gene

Paralogs for RBPMS Gene

Selected SIMAP similar genes for RBPMS Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RBPMS: view

Variants for RBPMS Gene

Sequence variations from dbSNP and Humsavar for RBPMS Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs952773 -- 30,417,970(-) TACGT(A/G)TGGTA intron-variant
rs952774 -- 30,417,826(-) GTAAT(A/G)TATTT intron-variant
rs954003 -- 30,417,621(-) ACTTC(C/T)GGACA intron-variant
rs1001898 -- 30,525,868(-) TTAGG(C/G)CTGGG intron-variant
rs1010054 -- 30,452,431(-) GTGAT(A/G)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBPMS Gene

Variant ID Type Subtype PubMed ID
nsv526509 CNV Gain 19592680
nsv509260 CNV Insertion 20534489
nsv890702 CNV Loss 21882294
esv2657168 CNV Deletion 23128226
esv2585826 CNV Deletion 19546169
esv2367432 CNV Deletion 18987734
esv4813 CNV Deletion 18987735
nsv396470 CNV Loss 16902084
esv988355 CNV Deletion 20482838
esv2736831 CNV Deletion 23290073
esv1086519 CNV Deletion 17803354
esv6638 CNV Loss 19470904
nsv528908 CNV Loss 19592680

Relevant External Links for RBPMS Gene

HapMap Linkage Disequilibrium report
RBPMS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBPMS Gene

Disorders for RBPMS Gene

Relevant External Links for RBPMS

Genetic Association Database (GAD)
RBPMS
Human Genome Epidemiology (HuGE) Navigator
RBPMS
genes like me logo Genes that share disorders with RBPMS: view

No data available for UniProtKB/Swiss-Prot for RBPMS Gene

Publications for RBPMS Gene

  1. A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs. (PMID: 8855282) Shimamoto A. … Furuichi Y. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Potentiation of Smad-mediated transcriptional activation by the RNA- binding protein RBPMS. (PMID: 17099224) Sun Y. … Ye Q. (Nucleic Acids Res. 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for RBPMS Gene

  • Addgene plasmids for RBPMS

Sources for RBPMS Gene

Back to Top

Content