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Aliases for RBPMS Gene

Aliases for RBPMS Gene

  • RNA Binding Protein With Multiple Splicing 2 3 5
  • Heart And RRM Expressed Sequence 3 4
  • HERMES 3 4
  • RBP-MS 4

External Ids for RBPMS Gene

Previous GeneCards Identifiers for RBPMS Gene

  • GC08P030157
  • GC08P030693
  • GC08P030299
  • GC08P030242
  • GC08P028786

Summaries for RBPMS Gene

Entrez Gene Summary for RBPMS Gene

  • This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

GeneCards Summary for RBPMS Gene

RBPMS (RNA Binding Protein With Multiple Splicing) is a Protein Coding gene. Diseases associated with RBPMS include colon carcinoma in situ. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBPMS2.

UniProtKB/Swiss-Prot for RBPMS Gene

  • Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.

Gene Wiki entry for RBPMS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBPMS Gene

Genomics for RBPMS Gene

Regulatory Elements for RBPMS Gene

Enhancers for RBPMS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RBPMS on UCSC Golden Path with GeneCards custom track

Promoters for RBPMS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBPMS on UCSC Golden Path with GeneCards custom track

Genomic Location for RBPMS Gene

Chromosome:
8
Start:
30,384,465 bp from pter
End:
30,572,261 bp from pter
Size:
187,797 bases
Orientation:
Plus strand

Genomic View for RBPMS Gene

Genes around RBPMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBPMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBPMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBPMS Gene

Proteins for RBPMS Gene

  • Protein details for RBPMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93062-RBPMS_HUMAN
    Recommended name:
    RNA-binding protein with multiple splicing
    Protein Accession:
    Q93062
    Secondary Accessions:
    • D3DSU9
    • Q92516
    • Q92517
    • Q92518
    • Q96J26

    Protein attributes for RBPMS Gene

    Size:
    196 amino acids
    Molecular mass:
    21802 Da
    Quaternary structure:
    • Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct.

    Three dimensional structures from OCA and Proteopedia for RBPMS Gene

    Alternative splice isoforms for RBPMS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBPMS Gene

Proteomics data for RBPMS Gene at MOPED

Post-translational modifications for RBPMS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBPMS Gene

Domains & Families for RBPMS Gene

Gene Families for RBPMS Gene

Protein Domains for RBPMS Gene

Graphical View of Domain Structure for InterPro Entry

Q93062

UniProtKB/Swiss-Prot:

RBPMS_HUMAN :
  • The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity.
Domain:
  • The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBPMS: view

Function for RBPMS Gene

Molecular function for RBPMS Gene

GENATLAS Biochemistry:
RNA binding protein gene with multiple transcripts,types 1,2,3,4,5
UniProtKB/Swiss-Prot Function:
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.

Gene Ontology (GO) - Molecular Function for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008143 poly(A) binding IDA 17099224
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBPMS: view
genes like me logo Genes that share phenotypes with RBPMS: view

Animal Model Products

miRNA for RBPMS Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBPMS Gene

Localization for RBPMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBPMS Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBPMS Gene COMPARTMENTS Subcellular localization image for RBPMS gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RBPMS: view

Pathways & Interactions for RBPMS Gene

genes like me logo Genes that share pathways with RBPMS: view

Pathways by source for RBPMS Gene

1 BioSystems pathway for RBPMS Gene

Gene Ontology (GO) - Biological Process for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing TAS 8855282
genes like me logo Genes that share ontologies with RBPMS: view

No data available for SIGNOR curated interactions for RBPMS Gene

Drugs & Compounds for RBPMS Gene

No Compound Related Data Available

Transcripts for RBPMS Gene

Unigene Clusters for RBPMS Gene

RNA binding protein with multiple splicing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8: - -
SP9: - - - - -
SP10:
SP11: - - - - -
SP12: - -

Relevant External Links for RBPMS Gene

GeneLoc Exon Structure for
RBPMS
ECgene alternative splicing isoforms for
RBPMS

Expression for RBPMS Gene

mRNA expression in normal human tissues for RBPMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBPMS Gene

This gene is overexpressed in Artery - Tibial (x4.4), Esophagus - Gastroesophageal Junction (x4.3), and Esophagus - Muscularis (x4.3).

Protein differential expression in normal tissues from HIPED for RBPMS Gene

This gene is overexpressed in Salivary gland (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBPMS Gene



SOURCE GeneReport for Unigene cluster for RBPMS Gene Hs.334587

mRNA Expression by UniProt/SwissProt for RBPMS Gene

Q93062-RBPMS_HUMAN
Tissue specificity: Ubiquitously expressed, at various levels depending on the isoform and the tissue.
genes like me logo Genes that share expression patterns with RBPMS: view

Protein tissue co-expression partners for RBPMS Gene

- Elite partner

Primer Products

Orthologs for RBPMS Gene

This gene was present in the common ancestor of animals.

Orthologs for RBPMS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBPMS 35
  • 96.35 (n)
  • 98.17 (a)
RBPMS 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBPMS 35
  • 97.87 (n)
  • 100 (a)
RBPMS 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbpms 35
  • 94.98 (n)
  • 99.54 (a)
Rbpms 16
Rbpms 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBPMS 35
  • 99.7 (n)
  • 100 (a)
RBPMS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbpms 35
  • 95.28 (n)
  • 99.54 (a)
oppossum
(Monodelphis domestica)
Mammalia RBPMS 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBPMS 35
  • 79.19 (n)
  • 89.6 (a)
RBPMS 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBPMS 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbpms 35
  • 80.95 (n)
  • 89.14 (a)
zebrafish
(Danio rerio)
Actinopterygii RBPMS 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cpo 37
  • 66 (a)
cpo 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mec-8 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9310 36
  • 23 (a)
OneToMany
Species with no ortholog for RBPMS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBPMS Gene

ENSEMBL:
Gene Tree for RBPMS (if available)
TreeFam:
Gene Tree for RBPMS (if available)

Paralogs for RBPMS Gene

Paralogs for RBPMS Gene

(1) SIMAP similar genes for RBPMS Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RBPMS: view

Variants for RBPMS Gene

Sequence variations from dbSNP and Humsavar for RBPMS Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7831068 -- 30,489,239(+) gtgtt(A/G)tctct intron-variant
rs7831379 -- 30,484,838(+) TTATA(A/C)ATATC intron-variant
rs7832273 -- 30,419,139(+) ACAGG(A/G)TTTTA intron-variant
rs7840356 -- 30,548,734(+) TGGGA(A/G)TAGTG intron-variant
rs7840384 -- 30,492,397(+) TATGT(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBPMS Gene

Variant ID Type Subtype PubMed ID
nsv526509 CNV Gain 19592680
nsv509260 CNV Insertion 20534489
nsv890702 CNV Loss 21882294
esv2657168 CNV Deletion 23128226
esv2585826 CNV Deletion 19546169
esv2367432 CNV Deletion 18987734
esv4813 CNV Deletion 18987735
nsv396470 CNV Loss 16902084
esv988355 CNV Deletion 20482838
esv2736831 CNV Deletion 23290073
esv1086519 CNV Deletion 17803354
esv6638 CNV Loss 19470904
nsv528908 CNV Loss 19592680

Variation tolerance for RBPMS Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBPMS Gene

HapMap Linkage Disequilibrium report
RBPMS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBPMS Gene

Disorders for RBPMS Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBPMS Gene - From: DISEASES

Disorder Aliases PubMed IDs
colon carcinoma in situ
  • carcinoma in situ of colon
- elite association - COSMIC cancer census association via MalaCards
Search RBPMS in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBPMS

Genetic Association Database (GAD)
RBPMS
Human Genome Epidemiology (HuGE) Navigator
RBPMS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBPMS
genes like me logo Genes that share disorders with RBPMS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBPMS Gene

Publications for RBPMS Gene

  1. A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs. (PMID: 8855282) Shimamoto A. … Furuichi Y. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23 67
  2. The RNA-binding protein RBPMS1 represses AP-1 signaling and regulates breast cancer cell proliferation and migration. (PMID: 25281386) Fu J. … Ye Q. (Biochim. Biophys. Acta 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3

Products for RBPMS Gene

Sources for RBPMS Gene

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