Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBPMS Gene

Aliases for RBPMS Gene

  • RNA Binding Protein With Multiple Splicing 2 3 5
  • Heart And RRM Expressed Sequence 3 4
  • HERMES 3 4
  • RNA-Binding Protein With Multiple Splicing 3
  • RBP-MS 4

External Ids for RBPMS Gene

Previous GeneCards Identifiers for RBPMS Gene

  • GC08P030157
  • GC08P030693
  • GC08P030299
  • GC08P030242
  • GC08P028786

Summaries for RBPMS Gene

Entrez Gene Summary for RBPMS Gene

  • This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

GeneCards Summary for RBPMS Gene

RBPMS (RNA Binding Protein With Multiple Splicing) is a Protein Coding gene. Diseases associated with RBPMS include Colon Carcinoma In Situ. Among its related pathways are Diurnally Regulated Genes with Circadian Orthologs. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBPMS2.

UniProtKB/Swiss-Prot for RBPMS Gene

  • Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).

Gene Wiki entry for RBPMS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBPMS Gene

Genomics for RBPMS Gene

Regulatory Elements for RBPMS Gene

Enhancers for RBPMS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G030419 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +37.6 37583 4.8 ATF1 FOXA2 ARNT ZFP64 FEZF1 ZNF48 TCF12 GATA2 FOS REST RBPMS-AS1 RBPMS GTF2E2 MBOAT4 PIR31328
GH08G030545 1.4 Ensembl ENCODE dbSUPER 17 +165.2 165238 8.2 PKNOX1 ATF1 ZFP64 ARID4B DMAP1 ZNF48 YY1 SP5 MXD4 REST RBPMS-AS1 RBPMS ENSG00000253112 RNU5A-3P GTF2E2 SMIM18 PIR40668 PIR38894
GH08G030561 1.5 Ensembl ENCODE dbSUPER 15.6 +181.2 181198 8.8 ATF1 FOXA2 ARNT ZNF133 YY1 TCF12 GATA2 ELK1 FOS REST RBPMS ENSG00000253112 RBPMS-AS1 SMIM18 GTF2E2 PIR39743
GH08G030554 1.5 Ensembl ENCODE dbSUPER 15.2 +171.9 171884 4.3 FOXA2 ATF1 AGO1 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS REST RBPMS ENSG00000253112 RBPMS-AS1 SMIM18 PIR47741 GC08M030557 PIR39743
GH08G030424 1.4 Ensembl ENCODE dbSUPER 13 +41.9 41942 2.9 ELF3 FOXA2 ZFP64 ARID4B RAD21 RARA MIXL1 HMG20B CEBPB PPARG RBPMS-AS1 RBPMS PIR31328
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBPMS on UCSC Golden Path with GeneCards custom track

Promoters for RBPMS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223068 1235 3801 ARID4B GLI4 ZNF48 YY1 ZNF121 GATA2 KLF7 FOS ZNF263 SP3

Genomic Location for RBPMS Gene

Chromosome:
8
Start:
30,384,465 bp from pter
End:
30,572,261 bp from pter
Size:
187,797 bases
Orientation:
Plus strand

Genomic View for RBPMS Gene

Genes around RBPMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBPMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBPMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBPMS Gene

Proteins for RBPMS Gene

  • Protein details for RBPMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93062-RBPMS_HUMAN
    Recommended name:
    RNA-binding protein with multiple splicing
    Protein Accession:
    Q93062
    Secondary Accessions:
    • D3DSU9
    • Q92516
    • Q92517
    • Q92518
    • Q96J26

    Protein attributes for RBPMS Gene

    Size:
    196 amino acids
    Molecular mass:
    21802 Da
    Quaternary structure:
    • Homodimer; each protein chain binds one RNA molecule via the external surface of the homodimer (PubMed:26347403). Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct (PubMed:17099224).

    Three dimensional structures from OCA and Proteopedia for RBPMS Gene

    Alternative splice isoforms for RBPMS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBPMS Gene

Post-translational modifications for RBPMS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RBPMS

No data available for DME Specific Peptides for RBPMS Gene

Domains & Families for RBPMS Gene

Gene Families for RBPMS Gene

Protein Domains for RBPMS Gene

Graphical View of Domain Structure for InterPro Entry

Q93062

UniProtKB/Swiss-Prot:

RBPMS_HUMAN :
  • The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity.
Domain:
  • The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity.
genes like me logo Genes that share domains with RBPMS: view

Function for RBPMS Gene

Molecular function for RBPMS Gene

GENATLAS Biochemistry:
RNA binding protein gene with multiple transcripts,types 1,2,3,4,5
UniProtKB/Swiss-Prot Function:
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).

Gene Ontology (GO) - Molecular Function for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003713 transcription coactivator activity IDA 17099224
GO:0003723 RNA binding IEA,IDA 22658674
GO:0005515 protein binding IPI 16189514
GO:0008143 poly(A) binding IDA 17099224
genes like me logo Genes that share ontologies with RBPMS: view
genes like me logo Genes that share phenotypes with RBPMS: view

Animal Model Products

CRISPR Products

miRNA for RBPMS Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBPMS Gene

Localization for RBPMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBPMS Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress. {ECO:0000269 PubMed:26347403}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBPMS gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005685 U1 snRNP IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RBPMS: view

Pathways & Interactions for RBPMS Gene

genes like me logo Genes that share pathways with RBPMS: view

Pathways by source for RBPMS Gene

1 BioSystems pathway for RBPMS Gene

Gene Ontology (GO) - Biological Process for RBPMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing TAS 8855282
GO:0006979 response to oxidative stress IMP 26347403
genes like me logo Genes that share ontologies with RBPMS: view

No data available for SIGNOR curated interactions for RBPMS Gene

Transcripts for RBPMS Gene

Unigene Clusters for RBPMS Gene

RNA binding protein with multiple splicing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8: - -
SP9: - - - - -
SP10:
SP11: - - - - -
SP12: - -

Relevant External Links for RBPMS Gene

GeneLoc Exon Structure for
RBPMS
ECgene alternative splicing isoforms for
RBPMS

Expression for RBPMS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBPMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBPMS Gene

This gene is overexpressed in Artery - Tibial (x4.4), Esophagus - Gastroesophageal Junction (x4.3), and Esophagus - Muscularis (x4.3).

Protein differential expression in normal tissues from HIPED for RBPMS Gene

This gene is overexpressed in Salivary gland (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBPMS Gene



Protein tissue co-expression partners for RBPMS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBPMS Gene:

RBPMS

SOURCE GeneReport for Unigene cluster for RBPMS Gene:

Hs.334587

mRNA Expression by UniProt/SwissProt for RBPMS Gene:

Q93062-RBPMS_HUMAN
Tissue specificity: Ubiquitously expressed, at various levels depending on the isoform and the tissue.

Evidence on tissue expression from TISSUES for RBPMS Gene

  • Eye(2.7)
  • Heart(2.6)
  • Muscle(2.3)
  • Gall bladder(2.2)
  • Intestine(2.1)
  • Thyroid gland(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with RBPMS: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RBPMS Gene

Orthologs for RBPMS Gene

This gene was present in the common ancestor of animals.

Orthologs for RBPMS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBPMS 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia RBPMS 34 35
  • 97.87 (n)
cow
(Bos Taurus)
Mammalia RBPMS 34 35
  • 96.35 (n)
rat
(Rattus norvegicus)
Mammalia Rbpms 34
  • 95.28 (n)
mouse
(Mus musculus)
Mammalia Rbpms 34 16 35
  • 94.98 (n)
oppossum
(Monodelphis domestica)
Mammalia RBPMS 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBPMS 34 35
  • 79.19 (n)
lizard
(Anolis carolinensis)
Reptilia RBPMS 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbpms 34
  • 80.95 (n)
zebrafish
(Danio rerio)
Actinopterygii RBPMS 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cpo 36 35
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea mec-8 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9310 35
  • 23 (a)
OneToMany
Species where no ortholog for RBPMS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBPMS Gene

ENSEMBL:
Gene Tree for RBPMS (if available)
TreeFam:
Gene Tree for RBPMS (if available)

Paralogs for RBPMS Gene

Paralogs for RBPMS Gene

(1) SIMAP similar genes for RBPMS Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RBPMS: view

Variants for RBPMS Gene

Sequence variations from dbSNP and Humsavar for RBPMS Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000020676 -- 30,556,798(+) GGGTA(A/G)GTATG intron-variant, downstream-variant-500B
rs1000034051 -- 30,512,721(+) GGCAA(A/G)AGCCA intron-variant
rs1000056607 -- 30,417,812(+) GTATG(A/G)ATGTT intron-variant
rs1000068424 -- 30,518,090(+) CACAT(C/T)TTACC intron-variant
rs1000068754 -- 30,458,989(+) ACGGA(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBPMS Gene

Variant ID Type Subtype PubMed ID
dgv3802n106 CNV deletion 24896259
esv1086519 CNV deletion 17803354
esv2367432 CNV deletion 18987734
esv2585826 CNV deletion 19546169
esv2657168 CNV deletion 23128226
esv2736831 CNV deletion 23290073
esv3272940 CNV deletion 24192839
esv3543294 CNV deletion 23714750
esv3572665 CNV loss 25503493
esv3616785 CNV loss 21293372
esv3616786 CNV loss 21293372
esv3616787 CNV loss 21293372
esv3616788 CNV loss 21293372
esv4813 CNV loss 18987735
esv6638 CNV loss 19470904
esv988355 CNV deletion 20482838
nsv1076077 CNV deletion 25765185
nsv396470 CNV deletion 16902084
nsv509260 CNV insertion 20534489
nsv526509 CNV gain 19592680
nsv528908 CNV loss 19592680
nsv957675 CNV deletion 24416366

Variation tolerance for RBPMS Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBPMS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBPMS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBPMS Gene

Disorders for RBPMS Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBPMS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colon carcinoma in situ
  • carcinoma in situ of colon
- elite association - COSMIC cancer census association via MalaCards
Search RBPMS in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBPMS

Genetic Association Database (GAD)
RBPMS
Human Genome Epidemiology (HuGE) Navigator
RBPMS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBPMS
genes like me logo Genes that share disorders with RBPMS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBPMS Gene

Publications for RBPMS Gene

  1. A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs. (PMID: 8855282) Shimamoto A. … Furuichi Y. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
  2. Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS. (PMID: 26347403) Teplova M. … Patel D.J. (Q. Rev. Biophys. 2015) 3 4 64
  3. Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs. (PMID: 22174390) Rankinen T. … Bouchard C. (J. Appl. Physiol. 2012) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Potentiation of Smad-mediated transcriptional activation by the RNA- binding protein RBPMS. (PMID: 17099224) Sun Y. … Ye Q. (Nucleic Acids Res. 2006) 3 4 64

Products for RBPMS Gene

Sources for RBPMS Gene

Content
Loading form....