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Aliases for RBPJL Gene

Aliases for RBPJL Gene

  • Recombination Signal Binding Protein For Immunoglobulin Kappa J Region Like 2 3
  • Recombination Signal Binding Protein For Immunoglobulin Kappa J Region-Like 2 3 5
  • Transcription Factor RBP-L 3 4
  • RBPSUHL 3 4
  • RBPL 3 4
  • Recombining Binding Protein Suppressor Of Hairless (Drosophila)-Like 2
  • SUHL 3

External Ids for RBPJL Gene

Previous HGNC Symbols for RBPJL Gene

  • RBPSUHL

Previous GeneCards Identifiers for RBPJL Gene

  • GC20P043369
  • GC20P043935
  • GC20P040677

Summaries for RBPJL Gene

Entrez Gene Summary for RBPJL Gene

  • This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RBPJL Gene

RBPJL (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region Like) is a Protein Coding gene. Among its related pathways are Viral carcinogenesis and Notch signaling pathway (KEGG). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is RBPJ.

UniProtKB/Swiss-Prot for RBPJL Gene

  • Putative transcription factor, which cooperates with EBNA2 to activate transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBPJL Gene

Genomics for RBPJL Gene

Regulatory Elements for RBPJL Gene

Genomic Location for RBPJL Gene

Chromosome:
20
Start:
45,306,824 bp from pter
End:
45,319,677 bp from pter
Size:
12,854 bases
Orientation:
Plus strand

Genomic View for RBPJL Gene

Genes around RBPJL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBPJL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBPJL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBPJL Gene

Proteins for RBPJL Gene

  • Protein details for RBPJL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBG7-RBPJL_HUMAN
    Recommended name:
    Recombining binding protein suppressor of hairless-like protein
    Protein Accession:
    Q9UBG7
    Secondary Accessions:
    • O95723
    • Q5QPU9
    • Q5QPV0
    • Q9ULV9

    Protein attributes for RBPJL Gene

    Size:
    517 amino acids
    Molecular mass:
    56751 Da
    Quaternary structure:
    • Interacts weakly with EBNA2. Does not interact with any Notch proteins (By similarity).

    Alternative splice isoforms for RBPJL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBPJL Gene

Proteomics data for RBPJL Gene at MOPED

Post-translational modifications for RBPJL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBPJL Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RBPJL

No data available for DME Specific Peptides for RBPJL Gene

Domains & Families for RBPJL Gene

Protein Domains for RBPJL Gene

Suggested Antigen Peptide Sequences for RBPJL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBG7

UniProtKB/Swiss-Prot:

RBPJL_HUMAN :
  • Contains 1 IPT/TIG domain.
  • Belongs to the Su(H) family.
Domain:
  • Contains 1 IPT/TIG domain.
Family:
  • Belongs to the Su(H) family.
genes like me logo Genes that share domains with RBPJL: view

No data available for Gene Families for RBPJL Gene

Function for RBPJL Gene

Molecular function for RBPJL Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor, which cooperates with EBNA2 to activate transcription.
genes like me logo Genes that share phenotypes with RBPJL: view

Animal Models for RBPJL Gene

MGI Knock Outs for RBPJL:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBPJL Gene

Localization for RBPJL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBPJL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBPJL Gene COMPARTMENTS Subcellular localization image for RBPJL gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for RBPJL Gene

Pathways & Interactions for RBPJL Gene

genes like me logo Genes that share pathways with RBPJL: view

Pathways by source for RBPJL Gene

1 BioSystems pathway for RBPJL Gene

Interacting Proteins for RBPJL Gene

Gene Ontology (GO) - Biological Process for RBPJL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction TAS 9929984
genes like me logo Genes that share ontologies with RBPJL: view

No data available for SIGNOR curated interactions for RBPJL Gene

Drugs & Compounds for RBPJL Gene

No Compound Related Data Available

Transcripts for RBPJL Gene

Unigene Clusters for RBPJL Gene

Recombination signal binding protein for immunoglobulin kappa J region-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBPJL Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for RBPJL Gene

GeneLoc Exon Structure for
RBPJL
ECgene alternative splicing isoforms for
RBPJL

Expression for RBPJL Gene

mRNA expression in normal human tissues for RBPJL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBPJL Gene

This gene is overexpressed in Pancreas (x52.6).

Protein differential expression in normal tissues from HIPED for RBPJL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.7) and Brain (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBPJL Gene



SOURCE GeneReport for Unigene cluster for RBPJL Gene Hs.248217

genes like me logo Genes that share expression patterns with RBPJL: view

Protein tissue co-expression partners for RBPJL Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RBPJL Gene

Orthologs for RBPJL Gene

This gene was present in the common ancestor of animals.

Orthologs for RBPJL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBPJL 35
  • 99.74 (n)
  • 99.61 (a)
RBPJL 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBPJL 36
  • 90 (a)
OneToOne
RBPJL 35
  • 87.98 (n)
  • 89.34 (a)
dog
(Canis familiaris)
Mammalia RBPJL 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbpjl 16
Rbpjl 35
  • 86.02 (n)
  • 88.16 (a)
Rbpjl 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBPJL 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBPJL 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbpjl 35
  • 86.02 (n)
  • 88.16 (a)
chicken
(Gallus gallus)
Aves RBPJL 35
  • 73.64 (n)
  • 74.9 (a)
RBPJL 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBPJL 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rbpjl 36
  • 61 (a)
OneToOne
rbpjl 35
  • 65.22 (n)
  • 65.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Su(H) 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lag-1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for RBPJL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBPJL Gene

ENSEMBL:
Gene Tree for RBPJL (if available)
TreeFam:
Gene Tree for RBPJL (if available)

Paralogs for RBPJL Gene

Paralogs for RBPJL Gene

(2) SIMAP similar genes for RBPJL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBPJL: view

Variants for RBPJL Gene

Sequence variations from dbSNP and Humsavar for RBPJL Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3091579 -- 45,318,728(+) GTGGT(A/G)TTGAA intron-variant, nc-transcript-variant
rs2741496 -- 45,317,926(-) AGACT(A/T)GTGGT nc-transcript-variant, downstream-variant-500B
rs2741497 -- 45,317,652(-) GGCAA(A/G)GGTAC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs2741499 -- 45,317,202(-) AAGAC(A/C)GGGAG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs2741500 -- 45,316,318(-) GGCAC(A/C/T)GGAGT nc-transcript-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for RBPJL Gene

Variant ID Type Subtype PubMed ID
nsv912891 CNV Loss 21882294

Variation tolerance for RBPJL Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBPJL Gene

HapMap Linkage Disequilibrium report
RBPJL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBPJL Gene

Disorders for RBPJL Gene

Relevant External Links for RBPJL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBPJL

No disorders were found for RBPJL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBPJL Gene

Publications for RBPJL Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 67
  2. Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L. (PMID: 9929984) Tani S. … Honjo T. (J. Hum. Genet. 1999) 2 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation. (PMID: 18834332) Rodolosse A. … Real F.X. (Biochem. J. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RBPJL Gene

Sources for RBPJL Gene

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