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RBP7 Gene

protein-coding   GIFtS: 49
GCID: GC01P010057

Retinol Binding Protein 7, Cellular

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinol Binding Protein 7, Cellular1 2     CRBP42 3
Cellular Retinoic Acid-Binding Protein 42 3     CRBPIV2
Cellular Retinoic Acid-Binding Protein IV2 3     Putative Cellular Retinol-Binding Protein CRBP IV2
CRABP-IV2 3     Retinoid Binding Protein 72
CRABP42 3     Retinoid-Binding Protein 72

External Ids:    HGNC: 303161   Entrez Gene: 1163622   Ensembl: ENSG000001624447   OMIM: 6086045   UniProtKB: Q96R053   

Export aliases for RBP7 gene to outside databases

Previous GC identifers: GC01P010018 GC01P009767 GC01P009991 GC01P009979 GC01P009212


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBP7 Gene:
Due to its chemical instability and low solubility in aqueous solution, vitamin A requires cellular
retinol-binding proteins (CRBPs), such as RBP7, for stability, internalization, intercellular transfer,
homeostasis, and metabolism.(supplied by OMIM, May 2004)

GeneCards Summary for RBP7 Gene:
RBP7 (retinol binding protein 7, cellular) is a protein-coding gene. GO annotations related to this gene include retinal binding and transporter activity. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: RET7_HUMAN, Q96R05
Function: Intracellular transport of retinol




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBP7 gene promoter:
         Elk-1   NF-1   Pax-5   NCX/Ncx   YY1   PPAR-alpha   AREB6   HEN1   Msx-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBP7 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

RBP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBP7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P010057:  view genomic region     (about GC identifiers)

Start:
10,057,255 bp from pter      End:
10,076,078 bp from pter
Size:
18,824 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RET7_HUMAN, Q96R05 (See protein sequence)
Recommended Name: Retinoid-binding protein 7  
Size: 134 amino acids; 15536 Da
1 PDB 3D structure from and Proteopedia for RBP7:
1LPJ (3D)    
Secondary accessions: B2R517 Q5SWJ4

Explore the universe of human proteins at neXtProt for RBP7: NX_Q96R05

Explore proteomics data for RBP7 at MOPED


See RBP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_443192.1  
ENSEMBL proteins: 
 ENSP00000324228   ENSP00000294435  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FABP: Fatty acid binding protein family

4 InterPro protein domains:
 IPR012674 Calycin
 IPR011038 Calycin-like
 IPR000463 Fatty_acid-bd
 IPR000566 Lipocln_cytosolic_FA-bd_dom

Graphical View of Domain Structure for InterPro Entry Q96R05

ProtoNet protein and cluster: Q96R05

1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: RET7_HUMAN, Q96R05
Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


Find genes that share domains with RBP7           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RET7_HUMAN, Q96R05
Function: Intracellular transport of retinol

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity IEA--
GO:0005501retinoid binding ----
GO:0008289lipid binding ----
GO:0016918retinal binding IEA--
GO:0019841retinol binding IEA--
     
Find genes that share ontologies with RBP7           About GenesLikeMe


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rbp7):
 homeostasis/metabolism 

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Animal Models:
     MGI mouse knock-out Rbp7tm1Vgl for RBP7

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RET7_HUMAN, Q96R05: Cytoplasm (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2
extracellular1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

Find genes that share ontologies with RBP7           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RBP7 About    
See pathways by source

SuperPathContained pathways About
1Vitamin A and carotenoid metabolism
Vitamin A and carotenoid metabolism

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RBP7
    Visual Cycle in Retinal Rods

1 BioSystems Pathway for RBP7
    Vitamin A and carotenoid metabolism



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Interactions:

    Search GeneGlobe Interaction Network for RBP7

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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  Browse compounds at ApexBio 

Browse Tocris compounds for RBP7 (RET7)

1 DrugBank Compound for RBP7    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8carrier--15493015 17139284 17016423



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RBP7 gene: 
NM_052960.2  

Unigene Cluster for RBP7:

Retinol binding protein 7, cellular
Hs.422688  [show with all ESTs]
Unigene Representative Sequence: BG218528
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000315901(uc001aqq.3 uc009vms.3) ENST00000294435
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Additional mRNA sequence: 

AF399927.1 AK312027.1 AY145438.1 BC063013.1 

2 DOTS entries:

DT.206419  DT.97818274 

Selected AceView cDNA sequences (see all 39):

BM091444 BM142634 BG198492 AL603589 BC063013 NM_052960 AF399927 BM091139 
AY145438 BG200083 BG212598 BC033883 AI791518 BM477848 BM973611 BI835720 
AA502122 AW448918 BG213621 BM955928 BG182975 BQ694038 BG194451 BG209962 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RBP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGGCCCTAG
RBP7 Expression
About this image

RBP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RBP7 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.422688

UniProtKB/Swiss-Prot: RET7_HUMAN, Q96R05
Tissue specificity: Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node,
appendix, ascending colon, and in fetal heart and spleen

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RBP7 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rbp71 , 5 retinol binding protein 7, cellular1, 5 87.06(n)1
89.55(a)1
  4 (79.40 cM)5
639541  NM_022020.21  NP_071303.11 
 1494496875 
chicken
(Gallus gallus)
Aves RBP71 retinol binding protein 7, cellular 75.87(n)
76.12(a)
  419447  XM_417606.4  XP_417606.4 
lizard
(Anolis carolinensis)
Reptilia RBP76
retinol binding protein 7, cellular
66(a)
1 ↔ 1
GL343709.1(190752-205086)
zebrafish
(Danio rerio)
Actinopterygii rbp7b1 retinol binding protein 7b, cellular 69.9(n)
67.91(a)
  569308  NM_001128750.1  NP_001122222.1 


ENSEMBL Gene Tree for RBP7 (if available)
TreeFam Gene Tree for RBP7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RBP7 gene
FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  FABP32  RBP12  
RBP22  CRABP12  FABP22  PMP22  FABP72  
Selected SIMAP similar genes for RBP7 using alignment to 3 protein entries:     RET7_HUMAN (see all proteins) (see all similar genes):
CALCOCO2    IK    DCAF17    MTO1    ETFA    TMX3
TBL2    ZNF415    TM4SF19    AAMDC    C14orf105    FKBP11
FRG1    MRPL45    SLC24A1    C12orf76    CLTA    PGS1

Find genes that share paralogs with RBP7           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RBP7 (see all 418)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1435676341,2
--10055265(+) ACCGCC/TGGCAA 1 -- us2k10--------
rs1468056191,2
--10055438(+) GGCAAC/TAGAGC 1 -- us2k10--------
rs1406223201,2
C--10055514(+) GGGAAA/GCTTAG 1 -- us2k10--------
rs1456140071,2
--10055730(+) CTAGGC/TGACAG 1 -- us2k10--------
rs1876326521,2
--10055731(+) TAGGCA/GACAGA 1 -- us2k10--------
rs1925391111,2
--10055861(+) GCAGGC/TGAATC 1 -- us2k10--------
rs1138845351,2
C,F--10055920(+) ATCTCC/TACTAA 1 -- us2k12Minor allele frequency- T:0.03CSA NA 121
rs1129780381,2
C,F--10055935(+) ACAAAC/AAATTA 1 -- us2k11Minor allele frequency- A:0.00CSA 1
rs1856452411,2
--10056001(+) AGAATC/GACTTG 1 -- us2k10--------
rs1877623911,2
--10056018(+) GGAGGC/TGGAGG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RBP7 (10057255 - 10076078 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RBP7:    About this table    
Variant IDTypeSubtypePubMed ID
esv2664618CNV Deletion23128226
esv2671412CNV Deletion23128226
esv2667343CNV Deletion23128226

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608604    OMIM disorders: --


Find genes that share disorders with RBP7           About GenesLikeMe


Export disorders for RBP7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RBP7 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with RBP7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Ligand binding and structural analysis of a human putative cellular retinol-binding protein. (PubMed id 12177003)1, 2, 3 Folli C.... Berni R. (J. Biol. Chem. 2002)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  5. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
  6. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
  7. CRBP-III:lacZ expression pattern reveals a novel heterogeneity of vascular endothelial cells. (PubMed id 15493015)7 Caprioli A....Sato T.N. (Genesis 2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Epigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma. (PubMed id 15720818)9 Kwong J....Huang D.P. (Neoplasia 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 116362 HGNC: 30316 AceView: RBP7 Ensembl:ENSG00000162444 euGenes: HUgn116362
ECgene: RBP7 H-InvDB: RBP7

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RBP7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RBP7 gene:
Search GeneIP for patents involving RBP7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RBP7  
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 OriGene Custom Antibody Services for RBP7   OriGene Custom Protein Services for RBP7  

 
 
 Block miRNA regulation of human, mouse, rat RBP7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RBP7
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBP7 Predesigned siRNA for gene silencing in human, mouse, rat RBP7
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 Custom PCR Arrays for RBP7 Search Chromatin IP Primers for RBP7
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBP7  Search GeneGlobe Interaction Network for RBP7
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 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Search Tocris compounds for RBP7 (RET7)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for RBP7
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP7
 SwitchGear 3'UTR luciferase reporter plasmids for RBP7
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 Search ThermoFisher Antibodies for RBP7
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP7
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBP7
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 LSBio Antibodies in human, mouse, rat for RBP7
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 Search Addgene for plasmids for RBP7
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  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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