RBP7 Gene
protein-coding GIFtS: 46
GCID: GC01P010057
|
|
retinol binding protein 7, cellular
| |
Aliases
for RBP7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Retinol Binding Protein 7, Cellular1 2 | | CRABP42 3 | | CRBPIV1 2 | | CRBP42 3 | | Cellular Retinoic Acid-Binding Protein 42 3 | | Putative Cellular Retinol-Binding Protein CRBP IV2 | | Cellular Retinoic Acid-Binding Protein IV2 3 | | Retinoid Binding Protein 72 | | CRABP-IV2 3 | | Retinoid-Binding Protein 72 |
Export aliases for RBP7 gene to outside databasesPrevious GC identifers: GC01P010018 GC01P009767 GC01P009991 GC01P009979 GC01P009212 |
Summaries
for RBP7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBP7:
Due to its chemical instability and low solubility in aqueous solution, vitamin A requires cellular retinol-bindingproteins (CRBPs), such as RBP7, for stability, internalization, intercellular transfer, homeostasis, andmetabolism.(supplied by OMIM, May 2004)
UniProtKB/Swiss-Prot: RET7_HUMAN, Q96R05Function: Intracellular transport of retinol
|
Genomic Views
for RBP7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBP7 gene promoter:
Elk-1 NF-1 Pax-5 NCX/Ncx YY1 PPAR-alpha AREB6 HEN1 Msx-1 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBP7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBP7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22RBP7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P010057: view genomic region
(about GC identifiers)
Start:
|
10,057,255 bp from pter |
End:
|
10,076,078 bp from pter |
Size:
|
18,824 bases |
Orientation:
|
plus strand |
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Proteins
for RBP7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RET7_HUMAN, Q96R05 (See
protein sequence)Recommended Name: Retinoid-binding protein 7 Size: 134 amino acids; 15536 Da
Subcellular location: Cytoplasm (By similarity)
1 PDB 3D structure from  and Proteopedia  for RBP7:1LPJ (3D)
Secondary accessions: B2R517 Q5SWJ4Explore the universe of human proteins at neXtProt for RBP7: NX_Q96R05
RBP7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443192.1
ENSEMBL proteins: ENSP00000324228 ENSP00000294435
Human Recombinant Protein Products for RBP7:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
RBP7 for ontologies About GeneDecksing
RBP7 Antibody Products:
Assay Products for RBP7: |
Protein
Domains /
Families
for RBP7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBP7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96R05ProtoNet protein and cluster: Q96R05 1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein
UniProtKB/Swiss-Prot: RET7_HUMAN, Q96R05Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interiorSimilarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family |
Function
for RBP7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RET7_HUMAN, Q96R05Function: Intracellular transport of retinol Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RBP7 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Rbp7):
RBP7 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Rbp7tm1Vgl for RBP7
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBP7
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP7 |
|
Pathways & Interactions
for RBP7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Vitamin A and carotenoid metabolism | |
1  BioSystems Pathway for RBP7
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBP7
|
Drugs & Compounds
for RBP7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBP7
1 DrugBank Compound for RBP7 About this table
Search CenterWatch for drugs/clinical trials and news about RBP7 / RET7
|
Transcripts
for RBP7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBP7 gene: NM_052960.2 Unigene Cluster for RBP7: Retinol binding protein 7, cellular Hs.422688 [show with all ESTs]Unigene Representative Sequence: BG2185282 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000315901(uc001aqq.3 uc009vms.3) ENST00000294435
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBP7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBP7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBP7 (NM_052960) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBP7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP7 |
Additional cDNA sequence: AF399927.1 AK312027.1 AY145438.1 BC063013.1 2 DOTS entries: DT.206419 DT.97818274 24/39 AceView cDNA sequences (see all 39): BG198492 BC063013 BM091444 AL603589 BM142634 AF399927 BM091139 BG200083 BC033883 AY145438 BM973611 AA502122 BM477848 AI791518 BG212598 NM_052960 BI835720 AW448918 BG209962 BG204684 BG182975 BQ694038 BG213621 BM955928
GeneLoc Exon Structure
|
Expression
for RBP7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCCCTAG
About this image
See RBP7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBP7
SOURCE GeneReport for Unigene cluster: Hs.422688
UniProtKB/Swiss-Prot: RET7_HUMAN, Q96R05Tissue specificity: Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node, appendix,ascending colon, and in fetal heart and spleen
SABiosciences Custom PCR Arrays for RBP7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBP7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBP7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBP7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBP7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP7 |
Orthologs
for RBP7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RBP7 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NMNAT16 |
Uncharacterized protein |
35(a) |
1 ↔ 1 |
21(3570285-3581255) |
lizard
(Anolis carolinensis) |
Reptilia |
RBP76 |
-- |
71(a) |
1 ↔ 1 |
GL343709.1(191257-200466) |
zebrafish
(Danio rerio) |
Actinopterygii |
rbp7b1 |
retinol binding protein 7b, cellular |
69.9(n)
67.91(a) |
|
569308 NM_001128750.1 NP_001122222.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
fabp6 |
fatty acid bindin protein |
24(a) |
possible ortholog |
3R(7385612-7392771) |
ENSEMBL Gene Tree for RBP7 (if available)
TreeFam Gene Tree for RBP7 (if available) |
Paralogs
for RBP7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBP7 gene
- FABP52 RBP52 FABP92 CRABP22 FABP122 FABP42 RBP12 FABP32
- CRABP12 RBP22 FABP22 PMP22 FABP72
18/35 SIMAP similar genes for RBP7 using alignment to 3 protein entries: RET7_HUMAN (see all proteins)
(see all similar genes):NRAMP1 C10orf137 TMEM14B LINC00596 UTY AURA2
TMEM135 c-myb MYB AGBL3 FAM175A RBP1
C16orf89 RBP5 RBP2 NF2 DNAPTP3 GLT8D2
RBP7 for paralogs About GeneDecksing
|
Genomic Variants
for RBP7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBP7 (10057255 - 10076078 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBP7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBP7 |
|
Disorders
/ Diseases
for RBP7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBP7 for disorders About GeneDecksing
OMIM gene information: 608604
OMIM disorders: --
7  diseases for RBP7: About MalaCardsretinol binding protein leber congenital amaurosis nasopharyngitis breast cancer
neuroblastoma retinitis carcinoma
Export disorders for RBP7 gene to outside databases
|
Publications
for RBP7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBP7 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with RBP7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ligand binding and structural analysis of a human putative cellular retinol-binding protein. (PubMed id 12177003)1, 2, 3 Folli C.... Berni R. (2002)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
- How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
- CRBP-III:lacZ expression pattern reveals a novel heterogeneity of vascular endothelial cells. (PubMed id 15493015)7 Caprioli A....Sato T.N. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Epigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma. (PubMed id 15720818)9 Kwong J....Huang D.P. (2005)
|
External Searches for RBP7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBP7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBP7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBP7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBP7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBP7 gene:
Search GeneIP for patents involving RBP7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBP7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP7 |
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