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Aliases for RBP7 Gene

Aliases for RBP7 Gene

  • Retinol Binding Protein 7 2 3 5
  • Cellular Retinoic Acid-Binding Protein IV 3 4
  • Cellular Retinoic Acid-Binding Protein 4 3 4
  • Retinol Binding Protein 7, Cellular 2 3
  • Cellular Retinol Binding Protein 7 2 3
  • CRABP-IV 3 4
  • CRABP4 3 4
  • CRBP4 3 4
  • Putative Cellular Retinol-Binding Protein CRBP IV 3
  • Retinoid Binding Protein 7 3
  • CRBPIV 3

External Ids for RBP7 Gene

Previous GeneCards Identifiers for RBP7 Gene

  • GC01P010018
  • GC01P009767
  • GC01P009991
  • GC01P009979
  • GC01P010057
  • GC01P009212

Summaries for RBP7 Gene

Entrez Gene Summary for RBP7 Gene

  • Due to its chemical instability and low solubility in aqueous solution, vitamin A requires cellular retinol-binding proteins (CRBPs), such as RBP7, for stability, internalization, intercellular transfer, homeostasis, and metabolism.[supplied by OMIM, May 2004]

GeneCards Summary for RBP7 Gene

RBP7 (Retinol Binding Protein 7) is a Protein Coding gene. Diseases associated with RBP7 include Leber Congenital Amaurosis. Among its related pathways are Visual Cycle in Retinal Rods and Vitamin A and carotenoid metabolism. GO annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is FABP3.

UniProtKB/Swiss-Prot for RBP7 Gene

  • Intracellular transport of retinol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP7 Gene

Genomics for RBP7 Gene

Regulatory Elements for RBP7 Gene

Enhancers for RBP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RBP7 on UCSC Golden Path with GeneCards custom track

Promoters for RBP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBP7 Gene

9,997,197 bp from pter
10,016,020 bp from pter
18,824 bases
Plus strand

Genomic View for RBP7 Gene

Genes around RBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP7 Gene

Proteins for RBP7 Gene

  • Protein details for RBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoid-binding protein 7
    Protein Accession:
    Secondary Accessions:
    • B2R517
    • Q5SWJ4

    Protein attributes for RBP7 Gene

    134 amino acids
    Molecular mass:
    15536 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP7 Gene

neXtProt entry for RBP7 Gene

Proteomics data for RBP7 Gene at MOPED

Post-translational modifications for RBP7 Gene

No Post-translational modifications

Other Protein References for RBP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBP7 Gene

Domains & Families for RBP7 Gene

Gene Families for RBP7 Gene

Suggested Antigen Peptide Sequences for RBP7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP7: view

Function for RBP7 Gene

Molecular function for RBP7 Gene

UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.

Gene Ontology (GO) - Molecular Function for RBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005515 protein binding IPI 25814554
GO:0008289 lipid binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP7: view
genes like me logo Genes that share phenotypes with RBP7: view

Animal Models for RBP7 Gene

MGI Knock Outs for RBP7:

Animal Model Products

  • Taconic Biosciences Mouse Models for RBP7

miRNA for RBP7 Gene

miRTarBase miRNAs that target RBP7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBP7 Gene

Localization for RBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP7 Gene


Subcellular locations from

Jensen Localization Image for RBP7 Gene COMPARTMENTS Subcellular localization image for RBP7 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for RBP7 Gene

Pathways & Interactions for RBP7 Gene

genes like me logo Genes that share pathways with RBP7: view

Pathways by source for RBP7 Gene

1 BioSystems pathway for RBP7 Gene
1 Qiagen pathway for RBP7 Gene

Interacting Proteins for RBP7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96R05-RET7_HUMAN ENSP00000294435 for RBP7 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for RBP7 Gene


No data available for SIGNOR curated interactions for RBP7 Gene

Drugs & Compounds for RBP7 Gene

(1) Drugs for RBP7 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved Nutra Carrier 438
genes like me logo Genes that share compounds with RBP7: view

Transcripts for RBP7 Gene

mRNA/cDNA for RBP7 Gene

Unigene Clusters for RBP7 Gene

Retinol binding protein 7, cellular:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBP7 Gene

No ASD Table

Relevant External Links for RBP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBP7 Gene

mRNA expression in normal human tissues for RBP7 Gene

mRNA differential expression in normal tissues according to GTEx for RBP7 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.0), Adipose - Subcutaneous (x7.1), and Breast - Mammary Tissue (x6.6).

Protein differential expression in normal tissues from HIPED for RBP7 Gene

This gene is overexpressed in Adrenal (42.6) and Nasopharynx (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBP7 Gene

SOURCE GeneReport for Unigene cluster for RBP7 Gene Hs.422688

mRNA Expression by UniProt/SwissProt for RBP7 Gene

Tissue specificity: Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node, appendix, ascending colon, and in fetal heart and spleen.
genes like me logo Genes that share expression patterns with RBP7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for RBP7 Gene

Orthologs for RBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBP7 35
  • 90.55 (n)
  • 87.31 (a)
RBP7 36
  • 87 (a)
(Canis familiaris)
Mammalia RBP7 35
  • 90.99 (n)
  • 92.79 (a)
RBP7 36
  • 76 (a)
(Mus musculus)
Mammalia Rbp7 35
  • 87.06 (n)
  • 89.55 (a)
Rbp7 16
Rbp7 36
  • 90 (a)
(Pan troglodytes)
Mammalia RBP7 35
  • 99.75 (n)
  • 100 (a)
RBP7 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Rbp7 35
  • 85.57 (n)
  • 88.06 (a)
(Monodelphis domestica)
Mammalia RBP7 36
  • 81 (a)
(Gallus gallus)
Aves RBP7 35
  • 75.87 (n)
  • 76.12 (a)
RBP7 36
  • 76 (a)
(Anolis carolinensis)
Reptilia RBP7 36
  • 66 (a)
(Danio rerio)
Actinopterygii rbp7b 35
  • 69.9 (n)
  • 67.91 (a)
rbp7a 36
  • 59 (a)
rbp7b 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9113 35
Species with no ortholog for RBP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP7 Gene

Gene Tree for RBP7 (if available)
Gene Tree for RBP7 (if available)

Paralogs for RBP7 Gene

Paralogs for RBP7 Gene

genes like me logo Genes that share paralogs with RBP7: view

Variants for RBP7 Gene

Sequence variations from dbSNP and Humsavar for RBP7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3013786 -- 10,002,861(+) GTAAC(C/T)GCAAA intron-variant
rs3013787 -- 10,002,993(+) tggaa(A/G)cagct intron-variant
rs3013788 -- 10,009,698(+) agcta(A/G)ttttt intron-variant
rs3123522 -- 10,012,539(+) gtagt(C/T)ccagt intron-variant
rs3125085 -- 10,001,613(+) CCTGG(C/T)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBP7 Gene

Variant ID Type Subtype PubMed ID
esv2667343 CNV Deletion 23128226
esv2671412 CNV Deletion 23128226
esv2664618 CNV Deletion 23128226

Variation tolerance for RBP7 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RBP7 Gene

Disorders for RBP7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBP7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards
Search RBP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RBP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBP7 Gene

Publications for RBP7 Gene

  1. Ligand binding and structural analysis of a human putative cellular retinol-binding protein. (PMID: 12177003) Folli C. … Berni R. (J. Biol. Chem. 2002) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. (PMID: 17940511) CarAcn H. … Martinsson T. (Br. J. Cancer 2007) 23
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for RBP7 Gene

Sources for RBP7 Gene