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Aliases for RBP7 Gene

Aliases for RBP7 Gene

  • Retinol Binding Protein 7, Cellular 2 3
  • Cellular Retinoic Acid-Binding Protein IV 3 4
  • Cellular Retinoic Acid-Binding Protein 4 3 4
  • CRABP-IV 3 4
  • CRABP4 3 4
  • CRBP4 3 4
  • Putative Cellular Retinol-Binding Protein CRBP IV 3
  • Retinoid Binding Protein 7 3
  • Retinoid-Binding Protein 7 3
  • CRBPIV 3

External Ids for RBP7 Gene

Previous GeneCards Identifiers for RBP7 Gene

  • GC01P010018
  • GC01P009767
  • GC01P009991
  • GC01P009979
  • GC01P010057
  • GC01P009212

Summaries for RBP7 Gene

Entrez Gene Summary for RBP7 Gene

  • Due to its chemical instability and low solubility in aqueous solution, vitamin A requires cellular retinol-binding proteins (CRBPs), such as RBP7, for stability, internalization, intercellular transfer, homeostasis, and metabolism.[supplied by OMIM, May 2004]

GeneCards Summary for RBP7 Gene

RBP7 (Retinol Binding Protein 7, Cellular) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods and Vitamin A and carotenoid metabolism. GO annotations related to this gene include transporter activity and retinal binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for RBP7 Gene

  • Intracellular transport of retinol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP7 Gene

Genomics for RBP7 Gene

Regulatory Elements for RBP7 Gene

Genomic Location for RBP7 Gene

9,997,197 bp from pter
10,016,020 bp from pter
18,824 bases
Plus strand

Genomic View for RBP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP7 Gene

Proteins for RBP7 Gene

  • Protein details for RBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoid-binding protein 7
    Protein Accession:
    Secondary Accessions:
    • B2R517
    • Q5SWJ4

    Protein attributes for RBP7 Gene

    134 amino acids
    Molecular mass:
    15536 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP7 Gene

neXtProt entry for RBP7 Gene

Proteomics data for RBP7 Gene at MOPED

Post-translational modifications for RBP7 Gene

No Post-translational modifications

Other Protein References for RBP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RBP7 Gene

Domains for RBP7 Gene

Gene Families for RBP7 Gene

  • FABP :Fatty acid binding protein family

Suggested Antigen Peptide Sequences for RBP7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96R05
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP7: view

Function for RBP7 Gene

Molecular function for RBP7 Gene

UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.

Gene Ontology (GO) - Molecular Function for RBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding --
GO:0008289 lipid binding --
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP7: view

Phenotypes for RBP7 Gene

genes like me logo Genes that share phenotypes with RBP7: view

Animal Models for RBP7 Gene

MGI Knock Outs for RBP7:

Animal Model Products

miRNA for RBP7 Gene

miRTarBase miRNAs that target RBP7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBP7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RBP7 Gene

Localization for RBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP7 Gene


Subcellular locations from

Jensen Localization Image for RBP7 Gene COMPARTMENTS Subcellular localization image for RBP7 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RBP7: view

Pathways for RBP7 Gene

genes like me logo Genes that share pathways with RBP7: view

Pathways by source for RBP7 Gene

1 Qiagen pathway for RBP7 Gene
1 BioSystems pathway for RBP7 Gene

Interacting Proteins for RBP7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000294435 for RBP7 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with RBP7: view

Compounds for RBP7 Gene

(1) Drugbank Compounds for RBP7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin A
  • [11,12-3H]-Retinol
68-26-8 carrier
genes like me logo Genes that share compounds with RBP7: view

Transcripts for RBP7 Gene

mRNA/cDNA for RBP7 Gene

Unigene Clusters for RBP7 Gene

Retinol binding protein 7, cellular:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBP7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBP7 Gene

No ASD Table

Relevant External Links for RBP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBP7 Gene

mRNA expression in normal human tissues for RBP7 Gene

mRNA differential expression in normal tissues according to GTEx for RBP7 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (8.0), Adipose - Subcutaneous (7.1), and Breast - Mammary Tissue (6.6).

Protein differential expression in normal tissues for RBP7 Gene

This gene is overexpressed in Adrenal (42.6) and Nasopharynx (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RBP7 Gene

SOURCE GeneReport for Unigene cluster for RBP7 Gene Hs.422688

mRNA Expression by UniProt/SwissProt for RBP7 Gene

Tissue specificity: Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node, appendix, ascending colon, and in fetal heart and spleen.
genes like me logo Genes that share expressions with RBP7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for RBP7 Gene

Orthologs for RBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBP7 35
  • 90.55 (n)
  • 87.31 (a)
RBP7 36
  • 87 (a)
(Canis familiaris)
Mammalia RBP7 35
  • 90.99 (n)
  • 92.79 (a)
RBP7 36
  • 76 (a)
(Mus musculus)
Mammalia Rbp7 35
  • 87.06 (n)
  • 89.55 (a)
Rbp7 16
Rbp7 36
  • 90 (a)
(Pan troglodytes)
Mammalia RBP7 35
  • 99.75 (n)
  • 100 (a)
RBP7 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Rbp7 35
  • 85.57 (n)
  • 88.06 (a)
(Monodelphis domestica)
Mammalia RBP7 36
  • 81 (a)
(Gallus gallus)
Aves RBP7 35
  • 75.87 (n)
  • 76.12 (a)
RBP7 36
  • 76 (a)
(Anolis carolinensis)
Reptilia RBP7 36
  • 66 (a)
(Danio rerio)
Actinopterygii rbp7b 35
  • 69.9 (n)
  • 67.91 (a)
rbp7a 36
  • 59 (a)
rbp7b 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9113 35
Species with no ortholog for RBP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP7 Gene

Gene Tree for RBP7 (if available)
Gene Tree for RBP7 (if available)

Paralogs for RBP7 Gene

genes like me logo Genes that share paralogs with RBP7: view

Variants for RBP7 Gene

Sequence variations from dbSNP and Humsavar for RBP7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3003377 -- 10,000,458(+) gaacc(C/T)gagag intron-variant
rs3003379 -- 10,003,350(+) gaatc(C/T)ggagg intron-variant
rs3123522 -- 10,012,539(+) gtagt(C/T)ccagt intron-variant
rs3125085 -- 10,001,613(+) CCTGG(C/T)GTACC intron-variant
rs3125088 -- 10,010,057(+) agtca(A/G)tcact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBP7 Gene

Variant ID Type Subtype PubMed ID
esv2667343 CNV Deletion 23128226
esv2671412 CNV Deletion 23128226
esv2664618 CNV Deletion 23128226

Relevant External Links for RBP7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBP7 Gene

Disorders for RBP7 Gene

No disorders were found for RBP7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RBP7 Gene

Publications for RBP7 Gene

  1. Ligand binding and structural analysis of a human putative cellular retinol-binding protein. (PMID: 12177003) Folli C. … Berni R. (J. Biol. Chem. 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for RBP7 Gene

Sources for RBP7 Gene

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