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Aliases for RBP5 Gene

Aliases for RBP5 Gene

  • Retinol Binding Protein 5, Cellular 2 3
  • Cellular Retinol-Binding Protein III 3 4
  • Retinol-Binding Protein 5, Cellular 2 3
  • CRBP-III 3 4
  • HRBPiso 3 4
  • CRBP3 3 6
  • Putative Cellular Retinol-Binding Protein CRBP III 3
  • Retinol-Binding Protein 5 3

External Ids for RBP5 Gene

Previous GeneCards Identifiers for RBP5 Gene

  • GC12M007234
  • GC12M007403
  • GC12M007176
  • GC12M007167
  • GC12M007089
  • GC12M007276

Summaries for RBP5 Gene

GeneCards Summary for RBP5 Gene

RBP5 (Retinol Binding Protein 5, Cellular) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Visual Cycle in Retinal Rods. GO annotations related to this gene include transporter activity and retinal binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for RBP5 Gene

  • Intracellular transport of retinol.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP5 Gene

Genomics for RBP5 Gene

Genomic Location for RBP5 Gene

7,123,684 bp from pter
7,128,942 bp from pter
5,259 bases
Minus strand

Genomic View for RBP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP5 Gene

Proteins for RBP5 Gene

  • Protein details for RBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinol-binding protein 5
    Protein Accession:
    Secondary Accessions:
    • Q53FB1

    Protein attributes for RBP5 Gene

    135 amino acids
    Molecular mass:
    15931 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP5 Gene

neXtProt entry for RBP5 Gene

Proteomics data for RBP5 Gene at MOPED

Post-translational modifications for RBP5 Gene

No Post-translational modifications

Other Protein References for RBP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RBP5 Gene

Domains for RBP5 Gene

Gene Families for RBP5 Gene

  • FABP :Fatty acid binding protein family

Suggested Antigen Peptide Sequences for RBP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P82980
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP5: view

Function for RBP5 Gene

Molecular function for RBP5 Gene

UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.

Gene Ontology (GO) - Molecular Function for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding TAS 11274389
GO:0005515 protein binding IPI 25416956
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP5: view

Phenotypes for RBP5 Gene

GenomeRNAi human phenotypes for RBP5:
genes like me logo Genes that share phenotypes with RBP5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBP5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RBP5 Gene

Localization for RBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP5 Gene


Subcellular locations from

Jensen Localization Image for RBP5 Gene COMPARTMENTS Subcellular localization image for RBP5 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RBP5: view

Pathways for RBP5 Gene

genes like me logo Genes that share pathways with RBP5: view

Interacting Proteins for RBP5 Gene

Gene Ontology (GO) - Biological Process for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with RBP5: view

Compounds for RBP5 Gene

(1) Drugbank Compounds for RBP5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin A
  • [11,12-3H]-Retinol
68-26-8 carrier
genes like me logo Genes that share compounds with RBP5: view

Transcripts for RBP5 Gene

Unigene Clusters for RBP5 Gene

Retinol binding protein 5, cellular:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBP5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBP5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for RBP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBP5 Gene

mRNA expression in normal human tissues for RBP5 Gene

mRNA differential expression in normal tissues according to GTEx for RBP5 Gene

This gene is overexpressed in Kidney - Cortex (22.2), Liver (13.0), and Spleen (5.4).

Protein differential expression in normal tissues for RBP5 Gene

This gene is overexpressed in Kidney (30.1) and Spleen (11.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RBP5 Gene

SOURCE GeneReport for Unigene cluster for RBP5 Gene Hs.246046

mRNA Expression by UniProt/SwissProt for RBP5 Gene

Tissue specificity: Higher expression in adult kidney and liver and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. Strongly decreased in hepatocellular carcinoma tissues (at protein level).
genes like me logo Genes that share expressions with RBP5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for RBP5 Gene

Orthologs for RBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBP5 35
  • 86.91 (n)
  • 83.7 (a)
RBP5 36
  • 84 (a)
(Canis familiaris)
Mammalia RBP5 35
  • 89.14 (n)
  • 87.41 (a)
RBP5 36
  • 87 (a)
(Pan troglodytes)
Mammalia RBP5 35
  • 99.01 (n)
  • 99.26 (a)
RBP5 36
  • 99 (a)
(Gallus gallus)
Aves RBP5 35
  • 68.4 (n)
  • 62.96 (a)
RBP5 36
  • 63 (a)
(Anolis carolinensis)
Reptilia RBP5 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbp5 35
  • 67.91 (n)
  • 63.43 (a)
(Danio rerio)
Actinopterygii rbp1a 36
  • 50 (a)
Species with no ortholog for RBP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP5 Gene

Gene Tree for RBP5 (if available)
Gene Tree for RBP5 (if available)

Paralogs for RBP5 Gene

Selected SIMAP similar genes for RBP5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBP5: view

Variants for RBP5 Gene

Sequence variations from dbSNP and Humsavar for RBP5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2290237 - 7,124,640(-) GAGAG(A/T)TGCTG reference, missense
rs2290238 -- 7,123,977(-) TCCCC(A/G)TGTTA utr-variant-3-prime
rs2290239 -- 7,123,655(-) CTTAT(C/T)CTTGA downstream-variant-500B
rs4883262 -- 7,128,179(+) CCCCA(G/T)GTTGT intron-variant
rs7969705 - 7,128,284(+) AAACT(C/G)CACTC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for RBP5 Gene

Variant ID Type Subtype PubMed ID
nsv818882 CNV Gain 17921354

Relevant External Links for RBP5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBP5 Gene

Disorders for RBP5 Gene

No disorders were found for RBP5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RBP5 Gene

Publications for RBP5 Gene

  1. Identification, retinoid binding and X-ray analysis of a human retinol-binding protein. (PMID: 11274389) Folli C. … Berni R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma. (PMID: 17497168) Ho J.C.Y. … Fan S.T. (J. Cancer Res. Clin. Oncol. 2007) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3

Products for RBP5 Gene

Sources for RBP5 Gene

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