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Aliases for RBP5 Gene

Aliases for RBP5 Gene

  • Retinol Binding Protein 5 2 3 5
  • Cellular Retinol-Binding Protein III 3 4
  • CRBP-III 3 4
  • HRBPiso 3 4
  • Putative Cellular Retinol-Binding Protein CRBP III 3
  • Retinol-Binding Protein 5, Cellular 2
  • Retinol Binding Protein 5, Cellular 3
  • Retinol-Binding Protein 5 3
  • CRBPIII 3
  • CRBP3 3

External Ids for RBP5 Gene

Previous GeneCards Identifiers for RBP5 Gene

  • GC12M007234
  • GC12M007403
  • GC12M007176
  • GC12M007167
  • GC12M007089
  • GC12M007276

Summaries for RBP5 Gene

Entrez Gene Summary for RBP5 Gene

  • The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]

GeneCards Summary for RBP5 Gene

RBP5 (Retinol Binding Protein 5) is a Protein Coding gene. Diseases associated with RBP5 include Total Anomalous Pulmonary Venous Return and Hepatocellular Carcinoma. Among its related pathways are PEDF Induced Signaling and the visual cycle I (vertebrates). GO annotations related to this gene include transporter activity and retinal binding. An important paralog of this gene is RBP1.

UniProtKB/Swiss-Prot for RBP5 Gene

  • Intracellular transport of retinol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP5 Gene

Genomics for RBP5 Gene

Regulatory Elements for RBP5 Gene

Enhancers for RBP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F007155 0.2 ENCODE 12 -25.1 -25104 0.2 GATA3 CUX1 DPF2 FOS ENSG00000256967 CLSTN3 RBP5 EMG1 PHB2 SCARNA12 PEX5
GH12F007156 0.2 ENCODE 12 -25.5 -25484 0.2 PKNOX1 ENSG00000256967 CLSTN3 RBP5 EMG1 PHB2 SCARNA12 C1RL PEX5
GH12F007162 0.7 ENCODE 11.5 -32.6 -32594 0.2 CTCF PKNOX1 KLF17 RAD21 RFX5 ZFHX2 ZNF366 ETV4 ZNF143 SMC3 CLSTN3 RBP5 ENSG00000256967 RNU6-485P C1RL-AS1 PEX5
GH12F007058 0.8 Ensembl 11.4 +71.8 71835 0.4 HDAC1 PTRF RARA ZBTB11 HDAC8 PPARG CREB3 TFDP1 MEF2D ZNF589 LPCAT3 C1R C1RL C1S CLSTN3 ENSG00000256967 RBP5 C1RL-AS1 RNU6-485P PIR36469
GH12F007008 0.6 Ensembl 10.7 +121.8 121836 0.4 C1S C1R C1RL EMG1 PHB2 SCARNA12 C1RL-AS1 RNU6-485P ENSG00000256967 RBP5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBP5 on UCSC Golden Path with GeneCards custom track

Promoters for RBP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000425893 -364 2001 PKNOX1 ATF1 ARID4B YBX1 ZNF48 SLC30A9 GLIS2 FOS ZNF263 SP3

Genomic Location for RBP5 Gene

Chromosome:
12
Start:
7,119,074 bp from pter
End:
7,130,236 bp from pter
Size:
11,163 bases
Orientation:
Minus strand

Genomic View for RBP5 Gene

Genes around RBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP5 Gene

Proteins for RBP5 Gene

  • Protein details for RBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82980-RET5_HUMAN
    Recommended name:
    Retinol-binding protein 5
    Protein Accession:
    P82980
    Secondary Accessions:
    • Q53FB1

    Protein attributes for RBP5 Gene

    Size:
    135 amino acids
    Molecular mass:
    15931 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP5 Gene

neXtProt entry for RBP5 Gene

Post-translational modifications for RBP5 Gene

No Post-translational modifications

Other Protein References for RBP5 Gene

Antibody Products

  • Abcam antibodies for RBP5

No data available for DME Specific Peptides for RBP5 Gene

Domains & Families for RBP5 Gene

Gene Families for RBP5 Gene

Suggested Antigen Peptide Sequences for RBP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82980

UniProtKB/Swiss-Prot:

RET5_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP5: view

Function for RBP5 Gene

Molecular function for RBP5 Gene

UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.

Gene Ontology (GO) - Molecular Function for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding TAS 11274389
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
genes like me logo Genes that share ontologies with RBP5: view
genes like me logo Genes that share phenotypes with RBP5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBP5 Gene

Localization for RBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBP5 Gene COMPARTMENTS Subcellular localization image for RBP5 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RBP5: view

Pathways & Interactions for RBP5 Gene

genes like me logo Genes that share pathways with RBP5: view

Gene Ontology (GO) - Biological Process for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with RBP5: view

No data available for SIGNOR curated interactions for RBP5 Gene

Drugs & Compounds for RBP5 Gene

(1) Drugs for RBP5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Carrier 468
genes like me logo Genes that share compounds with RBP5: view

Transcripts for RBP5 Gene

Unigene Clusters for RBP5 Gene

Retinol binding protein 5, cellular:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBP5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for RBP5 Gene

GeneLoc Exon Structure for
RBP5
ECgene alternative splicing isoforms for
RBP5

Expression for RBP5 Gene

mRNA expression in normal human tissues for RBP5 Gene

mRNA differential expression in normal tissues according to GTEx for RBP5 Gene

This gene is overexpressed in Kidney - Cortex (x22.2), Liver (x13.0), and Spleen (x5.4).

Protein differential expression in normal tissues from HIPED for RBP5 Gene

This gene is overexpressed in Kidney (30.1) and Spleen (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBP5 Gene



NURSA nuclear receptor signaling pathways regulating expression of RBP5 Gene:

RBP5

SOURCE GeneReport for Unigene cluster for RBP5 Gene:

Hs.246046

mRNA Expression by UniProt/SwissProt for RBP5 Gene:

P82980-RET5_HUMAN
Tissue specificity: Higher expression in adult kidney and liver and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. Strongly decreased in hepatocellular carcinoma tissues (at protein level).
genes like me logo Genes that share expression patterns with RBP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for RBP5 Gene

Orthologs for RBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBP5 34 35
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia RBP5 34 35
  • 89.14 (n)
cow
(Bos Taurus)
Mammalia RBP5 34 35
  • 86.91 (n)
chicken
(Gallus gallus)
Aves RBP5 34 35
  • 68.4 (n)
lizard
(Anolis carolinensis)
Reptilia RBP5 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbp5 34
  • 67.91 (n)
zebrafish
(Danio rerio)
Actinopterygii rbp1a 35
  • 50 (a)
OneToOne
Species where no ortholog for RBP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP5 Gene

ENSEMBL:
Gene Tree for RBP5 (if available)
TreeFam:
Gene Tree for RBP5 (if available)

Paralogs for RBP5 Gene

Paralogs for RBP5 Gene

(13) SIMAP similar genes for RBP5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBP5: view

Variants for RBP5 Gene

Sequence variations from dbSNP and Humsavar for RBP5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10743870 -- 7,118,824(+) AAGGA(C/T)ACAGA intron-variant, downstream-variant-500B
rs10772366 -- 7,125,865(+) GTAAG(C/T)CAGAG intron-variant
rs10772367 -- 7,125,942(+) TAAGC(C/G)TGAGA intron-variant
rs10772466 -- 7,131,888(+) GAGGA(A/C)AGAAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10845125 -- 7,121,497(+) GGTGG(A/T)GGCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBP5 Gene

Variant ID Type Subtype PubMed ID
nsv473997 CNV novel sequence insertion 20440878
nsv476400 CNV novel sequence insertion 20440878
nsv479883 CNV novel sequence insertion 20440878
nsv480239 CNV novel sequence insertion 20440878
nsv818882 CNV gain 17921354

Variation tolerance for RBP5 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.62; 95.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBP5 Gene

Human Gene Mutation Database (HGMD)
RBP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBP5 Gene

Disorders for RBP5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBP5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
total anomalous pulmonary venous return
  • total anomalous pulmonary venous return 1
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search RBP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBP5
genes like me logo Genes that share disorders with RBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBP5 Gene

Publications for RBP5 Gene

  1. Identification, retinoid binding and X-ray analysis of a human retinol-binding protein. (PMID: 11274389) Folli C. … Berni R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 22 64
  2. Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma. (PMID: 17497168) Ho J.C.Y. … Fan S.T. (J. Cancer Res. Clin. Oncol. 2007) 3 4 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. (PMID: 24793694) Kim J.Y. … Chakravarti D. (Mol. Cell 2014) 3 64

Products for RBP5 Gene

Sources for RBP5 Gene

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