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Aliases for RBP4 Gene

Aliases for RBP4 Gene

  • Retinol Binding Protein 4, Plasma 2 3
  • Plasma Retinol-Binding Protein 3 4
  • RDCCAS 3 6
  • PRBP 3 4
  • RBP 3 4
  • Retinol-Binding Protein 4, Interstitial 3
  • Retinol-Binding Protein 4, Plasma 2
  • Retinol-Binding Protein 4 3

External Ids for RBP4 Gene

Summaries for RBP4 Gene

Entrez Gene Summary for RBP4 Gene

  • This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBP4 Gene

RBP4 (Retinol Binding Protein 4, Plasma) is a Protein Coding gene. Diseases associated with RBP4 include pseudotumor cerebri and hypervitaminosis a. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include protein heterodimerization activity and retinal binding.

UniProtKB/Swiss-Prot for RBP4 Gene

  • Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli

Gene Wiki entry for RBP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP4 Gene

Genomics for RBP4 Gene

Genomic Location for RBP4 Gene

93,591,687 bp from pter
93,601,744 bp from pter
10,058 bases
Minus strand

Genomic View for RBP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP4 Gene

Regulatory Elements for RBP4 Gene

Proteins for RBP4 Gene

  • Protein details for RBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinol-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • D3DR38
    • O43478
    • O43479
    • Q5VY24
    • Q8WWA3
    • Q9P178

    Protein attributes for RBP4 Gene

    201 amino acids
    Molecular mass:
    23010 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF69622.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBP4 Gene

neXtProt entry for RBP4 Gene

Proteomics data for RBP4 Gene at MOPED

Post-translational modifications for RBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBP4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RBP4 Gene

Domains for RBP4 Gene

Gene Families for RBP4 Gene

  • LCN :Lipocalins


  • Belongs to the calycin superfamily. Lipocalin family.:
    • P02753
genes like me logo Genes that share domains with RBP4: view

Function for RBP4 Gene

Molecular function for RBP4 Gene

GENATLAS Biochemistry: retinol binding protein 4,serum (lipocalin family,Kernel group),monomer,binding to transthyretin
UniProtKB/Swiss-Prot Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli

Gene Ontology (GO) - Molecular Function for RBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005501 retinoid binding --
GO:0005515 protein binding IPI 12228058
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IDA 571335
genes like me logo Genes that share ontologies with RBP4: view
genes like me logo Genes that share phenotypes with RBP4: view

Animal Models for RBP4 Gene

MGI Knock Outs for RBP4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RBP4 Gene

Localization for RBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP4 Gene


Subcellular locations from

Jensen Localization Image for RBP4 Gene COMPARTMENTS Subcellular localization image for RBP4 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RBP4: view

Pathways for RBP4 Gene

genes like me logo Genes that share pathways with RBP4: view

Gene Ontology (GO) - Biological Process for RBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0001654 eye development ISS --
GO:0006094 gluconeogenesis ISS --
GO:0006810 transport --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with RBP4: view

Compounds for RBP4 Gene

(5) Drugbank Compounds for RBP4 Gene

(74) Novoseek inferred chemical compound relationships for RBP4 Gene

Compound -log(P) Hits PubMed IDs
vitamin a 94.8 423
retinyl palmitate 65.6 5
retinoid 63.5 20
n-4-methoxyphenylretinamide 62.1 2
creatinine 58.4 67
genes like me logo Genes that share compounds with RBP4: view

Transcripts for RBP4 Gene

mRNA/cDNA for RBP4 Gene

Unigene Clusters for RBP4 Gene

Retinol binding protein 4, plasma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBP4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for RBP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBP4 Gene

mRNA expression in normal human tissues for RBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBP4 Gene

This gene is overexpressed in Liver (41.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RBP4 Gene

SOURCE GeneReport for Unigene cluster for RBP4 Gene Hs.50223

genes like me logo Genes that share expressions with RBP4: view

Orthologs for RBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBP4 36
  • 99.5 (n)
  • 100 (a)
RBP4 37
  • 100 (a)
(Bos Taurus)
Mammalia RBP4 36
  • 91.21 (n)
  • 91.54 (a)
RBP4 37
  • 92 (a)
(Canis familiaris)
Mammalia RBP4 36
  • 91.38 (n)
  • 93.03 (a)
RBP4 37
  • 88 (a)
(Mus musculus)
Mammalia Rbp4 36
  • 85.24 (n)
  • 85.57 (a)
Rbp4 16
Rbp4 37
  • 70 (a)
(Monodelphis domestica)
Mammalia RBP4 37
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia RBP4 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Rbp4 36
  • 84.74 (n)
  • 85.57 (a)
(Gallus gallus)
Aves RBP4 36
  • 77.65 (n)
  • 86.59 (a)
RBP4 37
  • 82 (a)
(Anolis carolinensis)
Reptilia RBP4 37
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia rbp4-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rbp4 36
  • 65.74 (n)
  • 62.78 (a)
(Danio rerio)
Actinopterygii rbp4 36
  • 65.71 (n)
  • 62.29 (a)
rbp4 37
  • 57 (a)
Species with no ortholog for RBP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP4 Gene

Gene Tree for RBP4 (if available)
Gene Tree for RBP4 (if available)

Paralogs for RBP4 Gene

No data available for Paralogs for RBP4 Gene

Variants for RBP4 Gene

Sequence variations from dbSNP and Humsavar for RBP4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1060633 -- 93,596,280(-) AAATC(C/G)AAGTA intron-variant
rs3215968 -- 93,596,218(-) GGAGG(-/A)AAAAA intron-variant
rs3758537 -- 93,602,870(-) AGAAC(C/T)TGGAG upstream-variant-2KB
rs3758538 -- 93,602,293(-) AATCG(A/C)TATTG upstream-variant-2KB
rs3758539 -- 93,601,831(-) AGGGA(A/G)GGTTT upstream-variant-2KB

Relevant External Links for RBP4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Structural Variations from Database of Genomic Variants (DGV) for RBP4 Gene

Disorders for RBP4 Gene

(1) OMIM Diseases for RBP4 Gene (180250)


  • Retinal dystrophy, iris coloboma, and comedogenic acne syndrome (RDCCAS) [MIM:615147]: A disease characterized by retinal degeneration, ocular colobomas involving both the anterior and posterior segment, impaired night vision and loss of visual acuity. Additional characteristic features include developmental abnormalities and severe acne. {ECO:0000269 PubMed:23189188, ECO:0000269 PubMed:9888420}. Note=The disease is caused by mutations affecting the gene represented in this entry. Loss of functional RBP4 protein results in serum retinol deficiency. Lack of normal levels of retinol impairs the visual cycle leading to night blindness at early stages; prolonged deficiency may lead to retinal degeneration. Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne (PubMed:23189188). {ECO:0000269 PubMed:23189188}.

(2) University of Copenhagen DISEASES for RBP4 Gene

(81) Novoseek inferred disease relationships for RBP4 Gene

Disease -log(P) Hits PubMed IDs
vitamin a deficiency 82.8 24
insulin resistance 79.7 213
insulin sensitivity 68.6 54
hypervitaminosis a 63.5 1
obesity 55.7 69

Genatlas disease for RBP4 Gene

night blindness and progressive atrophy of the retinal pigment epithelium,autosomal recessive,with retinol binding protein 4 deficiency

Relevant External Links for RBP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RBP4: view

Publications for RBP4 Gene

  1. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. (PMID: 10052934) Naylor H.M. … Newcomer M.E. (Biochemistry 1999) 3 4 23
  2. Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure. (PMID: 7666002) Jaconi S. … Siegenthaler G. (J. Lipid Res. 1995) 3 4 23
  3. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. (PMID: 17174134) Craig R.L. … Elbein S.C. (Mol. Genet. Metab. 2007) 3 23 49
  4. Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression. (PMID: 17728376) Kovacs P. … Stumvoll M. (Diabetes 2007) 3 23 49
  5. Effect of RBP4 gene variants on circulating RBP4 concentration and type 2 diabetes in a Chinese population. (PMID: 18199128) Hu C. … Xiang K. (Diabet. Med. 2008) 3 23 49

Products for RBP4 Gene

Sources for RBP4 Gene

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