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RBP4 Gene

protein-coding GIFtS: 60

GC10M095341

retinol binding protein 4, plasma
(Previous names: retinol-binding protein 4, plasma )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000020114 ^²
OTTHUMP00000020116 ^²
PRBP ^³
RBP ^³

Descriptions
Plasma retinol-binding protein ^³
retinol binding protein 4, plasma ^²
retinol-binding protein 4, interstitial ^²
retinol-binding protein 4, plasma ^¹, ²

External Ids
HGNC: 9922¹
Entrez Gene: 5950²
UniProtKB: P02753³
Ensembl: ENSG00000138207⁷

Search outside databases for aliases for RBP4 gene

Previous GC identifers: GC10M094244 GC10M094585 GC10M095482 GC10M095016

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RBP4:

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A

alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In

plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration

through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein

posttranslationally and results in defective delivery and supply to the epidermal cells. [provided

by RefSeq]

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753

Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the

RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the

kidney glomeruli

Gene Wiki entry for RBP4 (Retinol_binding_protein_4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RBP4 gene

Entrez Gene cytogenetic band: 10q23-q24 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q23-q24

RBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M095341: (about GC identifiers)

Start:	95,341,434 bp from pter
End:	95,351,491 bp from pter
Size:	10,058 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RET4_HUMAN, P02753 (See protein sequence)

Recommended Name: Retinol-binding protein 4 precursor

Size: 201 amino acids; 23010 Da

Subcellular location: Secreted

Mass spectrometry: Mass=21063.46; Mass_error=1.88; Method=Electrospray; Range=17-199;

Source=PubMed:7666002;

Mass spectrometry: Mass=20534; Method=MALDI; Range=19-197; Source=PubMed:12237133;

Mass spectrometry: Mass=20162; Method=MALDI; Range=19-194; Source=PubMed:12237133;

PDB structures from and Proteopedia :

1BRP (3D)

1BRQ (3D)

1JYD (3D)

1JYJ (3D)

1QAB (3D)

1RBP (3D)

1RLB (3D)

3BSZ (3D)

3FMZ (3D)

Secondary accessions: O43478 O43479 Q5VY24 Q8WWA3 Q9P178

REFSEQ proteins: NP_006735.2

ENSEMBL proteins:

ENSP00000360522 ENSP00000360519 ENSP00000360524 ENSP00000360518

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for RBP4
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Retinol Binding Protein RBP, RBP4)
	Human Recombinant Proteins from Abnova (RBP4)

OriGene Purified Recombinant Human Protein: RBP4

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	ISS	--
GO:0005634	nucleus	IDA	18029348
GO:0005730	NOT nucleolus	IDA	18029348

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Antibodies for RBP4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RBP4
	R&D Systems Antibodies for RBP4
	Antibodies from Abcam (Retinol Binding Protein RBP, RBP4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RBP4)
	Novus Biologicals Antibodies for RBP4

Assays for RBP4:

	Invitrogen Assays for RBP4
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for RBP4 (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02753

ProtoNet protein and cluster: P02753

2 Blocks protein families:

IPB002345 Lipocalin signature

IPB002449 Retinol binding protein signature

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753

Similarity: Belongs to the calycin superfamily. Lipocalin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RBP4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RBP4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006744

Applied Biosystems Silencer® siRNAs for RBP4

Sigma-Aldrich siRNA and siRNA Panels for RBP4

Sigma-Aldrich shRNA for RBP4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RBP4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006744
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006744
untagged cDNA clone in CMV expression vector: NM_006744

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006744

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753

Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the

RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the

kidney glomeruli

Genatlas biochemistry entry for RBP4:

retinol binding protein 4,serum (lipocalin family,Kernel group),monomer,binding to transthyretin

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rbp4):

	endocrine/exocrine gland	homeostasis/metabolism	muscle	normal
reproductive system	vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005488	binding	IEA	--
GO:0016918	retinal binding	IEA	--
GO:0019841	retinol binding	IEA	--
GO:0034632	retinol transporter activity	IC	571335

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for RBP4 (Your Favorite Gene powered by Ingenuity)

RAR Activation
Acute Phase Response Signaling

GeneDecks RBP4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for RBP4

5/7 Interacting proteins for RBP4 (ENSP00000360522³) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TTR	ENSP00000237014³	STRING (score=.989)
RB1	ENSP00000267163³	STRING (score=.851)
INS	ENSP00000370731³	STRING (score=.763)
ALB	ENSP00000370290³	STRING (score=.755)
ADIPOQ	ENSP00000320709³	STRING (score=.736)

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5/23 Gene Ontology (GO) biological process terms (links to tree view) (see all 23 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001654	eye development	ISS	--
GO:0006094	gluconeogenesis	ISS	--
GO:0006810	transport	IEA	--
GO:0007601	visual perception	IEA	--
GO:0030277	maintenance of gastrointestinal epithelium	IDA	10944490

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RBP4
10/43 Novoseek chemical compound relationships for RBP4 gene (see all 43 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
n-4-methoxyphenylretinamide	63.29	2	7586162 (1), 2140925 (1)
retinyl ester	55.91	2	8290933 (2)
purpurin	51.85	4	1601873 (2), 1915658 (1)
glucose	48.48	165	18430770 (5), 19190263 (5), 18466349 (4), 17656599 (4) (see all 54)
cadmium	39.52	32	9614399 (4), 7719661 (3), 12849688 (3), 12733083 (3) (see all 11)
1,3-dichloropropene	35.86	1	8243412 (1)
cholesterol	33.39	35	8669421 (4), 18782570 (2), 16843945 (2), 17890490 (2) (see all 23)
lipid	30.70	26	17292720 (2), 18199128 (2), 17986278 (1), 18430770 (1) (see all 16)
zinc	29.76	42	9881002 (5), 11240140 (4), 10702174 (3), 11926045 (2) (see all 17)
vitamin-e	29.75	9	8839511 (2), 8316755 (1), 9554560 (1), 10648269 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RBP4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RBP4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006744

Sigma-Aldrich siRNA and siRNA Panels for RBP4

Sigma-Aldrich shRNA for RBP4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006744

REFSEQ mRNAs for RBP4 gene:

NM_006744.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006744

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006744
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006744
                                 untagged cDNA clone in CMV expression vector: NM_006744

Additional cDNA sequence:

BC020633.1 X00129.1

11 DOTS entries:

DT.449609 DT.101987968 DT.95269390 DT.121212756 DT.108214 DT.95269391 DT.100740972 DT.95269382

DT.121212750 DT.91783506 DT.95269381

24/276 AceView cDNA sequences (see all 276 ):

AA742458 H28527 CA771937 BQ269598 AV648544 H25489 CA867042 H26422

BQ271126 BQ271418 AV718975 BQ787983 H21451 AV652752 BM090826 AV662271

AI132990 CA776212 AI111174 BU077944 CA772098 R54700 BX496564 AV683638

highest scoring ESTs for RBP4:

X00129 AV648043 AV648119 AV648272 AV648275 AV648504 AV648515 AV648525 AV648544 AV649661

Unigene Cluster for RBP4:

Retinol binding protein 4, plasma

Hs.50223 [show with all ESTs]

Unigene Representative Sequence: BQ064708

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RBP4

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9
SP1:																	-
SP2:																	-
SP3:			-		-
SP4:																	-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for RBP4

4 Ensembl transcripts including schematic representations:

ENST00000371467 ENST00000371464 ENST00000371469 ENST00000371463

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RBP4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RBP4

¹ / ² / ³

3 probe-sets matching RBP4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32552_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X00129	1.00	1.00	1.00	1
219140_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006744	0.60	1.00	0.82	1
219140_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RBP4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGGCACCT

SOURCE GeneReport for Unigene cluster: Hs.50223
Expression variation in blood from EXPOLDB for RBP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RBP4 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RBP4¹	--	retinol binding protein 4, plasma	91.38(n) 93.03(a)	477775 XM_534969.2 XP_534969.2
chimpanzee (Pan troglodytes)	RBP4¹	--	retinol binding protein 4, plasma	99.34(n) 100(a)	450617 XM_001148374.1 XP_001148374.1
rat (Rattus norvegicus)	Rbp4¹	--	retinol binding protein 4, plasma	84.74(n) 85.57(a)	25703 XM_215285.4 XP_215285.3
mouse (Mus musculus)	Rbp4^{1, 5}	19 (38.00 cM)⁵	retinol binding protein 4, plasma^{1, 5}	85.24(n)¹ 85.57(a)¹	19662¹ NM_011255.2¹ NP_035385.1¹ AB124638⁵ AI326915⁵ (see all 15)
chicken (Gallus gallus)	RBP4¹	--	retinol binding protein 4, plasma	76.04(n) 84.37(a)	396166 NM_205238.1 NP_990569.1

About this table Species with no ortholog for RBP4

ENSEMBL Gene Tree for RBP4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/86 NCBI SNPs in RBP4 are shown (see all 86 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 64)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3758538^1,2	C,F,H	95352040(-)	`AATCGA/CTATTG`	1	--	ng3¹ tfbs³		9		EA EU WA	2322
	rs3758539^1,2	C,F	95351578(-)	`AGGGAG/AGGTTT`	1	--	ng3¹		5		EA NA	1840
--	rs3758537^1,2	A,C	95352617(-)	`AGAACC/TTGGAG`	1	--	ng3¹		0	--	--	--	--
--	rs10882283^1,2	A	95350954(+)	`CGCCGA/CGTCCG`	1	--	ut5¹		0	--	--	--	--
	rs34812400^1,2	F	95343757(-)	`GACACA/GGACTA`	1	T/T	syn¹		1		NA	64
	rs11187545^1,2	A,C,F,H	95347095(+)	`TTTCTA/GCAAGA`	1	--	int¹		12		EU EA WA	1254
	rs10882278^1,2	A,C,F,H	95349151(+)	`TCACCG/AAGCAG`	1	--	int¹		8		EU EA WA	828
	rs10882280^1,2	A,C,F,H	95349303(+)	`ATTGGC/ATCTAA`	1	--	int¹		8		EU EA WA	838
	rs7094671^1,2	A,C,F,H	95345607(+)	`CTCCTG/ATGCCT`	1	--	int¹		4		EU EA WA	412
	rs13376835^1,2	A,C,F,H	95342163(+)	`GTCGGA/GGGCCA`	1	--	int¹		4		EU EA WA	414

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HapMap Linkage Disequilibrium images for RBP4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 180250

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753

Defects in RBP4 are a cause of retinol-binding protein deficiency [MIM:180250]. This

condition causes night vision problems. It produces a typical "fundus xerophthalmicus," featuring

a progressed atrophy of the retinal pigment epithelium

A deficiency of vitamin A blocks secretion of the binding protein post-translationally and

results in defective delivery and supply of vitamin to the epidermal cells (a condition associated

with a dermatosis)

10/76 Novoseek disease relationships for RBP4 gene (see all 76 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin a deficiency	83.29	29	14749226 (3), 16702331 (2), 1493768 (1), 16208398 (1) (see all 18)
insulin resistance	75.46	347	18390799 (7), 18588869 (7), 18641048 (5), 18397979 (5) (see all 95)
insulin sensitivity	66.24	62	18239568 (5), 17405846 (3), 18430770 (3), 17294166 (3) (see all 27)
hypervitaminosis a	65.53	1	1517032 (1)
proximal renal tubular dysfunction	56.95	1	8084448 (1)
albuminuria	56.17	10	12702785 (2), 18973209 (2), 2250610 (1), 9203174 (1) (see all 5)
protein-energy malnutrition	54.14	1	11470636 (1)
proteinuria	52.40	18	10620205 (5), 8084448 (2), 8448868 (2), 1379421 (1) (see all 11)
obesity	51.47	105	17341558 (4), 16034410 (3), 18381580 (3), 17726085 (3) (see all 39)
microalbuminuria	50.08	11	17568782 (4), 15016173 (2), 18973209 (2), 17875187 (1) (see all 6)

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Genatlas disease: RBP4

night blindness and progressive atrophy of the retinal pigment epithelium,autosomal recessive,with

retinol binding protein 4 deficiency

Human Gene Mutation Database: RBP4
Human Genome Epidemiology Navigator: RBP4 (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/505 PubMed articles for RBP4 gene (see all 505 ):

The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. (PubMed id 10052934)^{1, 3, 4} Naylor H.M. and Newcomer M.E. (1999)
Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure. (PubMed id 7666002)^{1, 3, 4} Jaconi S.... Siegenthaler G. (1995)
Comparative urine protein phenotyping using mass spectrometric immunoassay. (PubMed id 12716133)^{1, 3, 4} Kiernan U.A.... Nelson R.W. (2003)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Comparative phenotypic analyses of human plasma and urinary retinol binding protein using mass spectrometric immunoassay. (PubMed id 12237133)^{3, 4} Kiernan U.A.... Nelson R.W. (2002)
Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. (PubMed id 9888420)^{3, 4} Seeliger M.W.... Zrenner E. (1999)
Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. (PubMed id 10232633)^{3, 4} Biesalski H.K.... Zrenner E. (1999)
Three-dimensional structure and active site of three hydrophobic molecule-binding proteins with significant amino acid sequence similarity. (PubMed id 1623143)^{3, 4} Monaco H.L. and Zanotti G. (1992)
Crystallographic refinement of human serum retinol binding protein at 2-A resolution. (PubMed id 2217163)^{3, 4} Cowan S.W.... Jones T.A. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5950	HGNC: 9922	AceView: RBP4	Ensembl:ENSG00000138207	euGenes: HUgn5950
ECgene: RBP4	H-InvDB: RBP4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Mutations of the RBP4 gene	http://www.retina-international.com/sci-news/rlbp4mut.htm
Wikipedia	http://en.wikipedia.org/wiki/Retinol_binding_protein_4

Licensable Technologies for RBP4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RBP4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RBP4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RBP4		Antibodies for RBP4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RBP4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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Antibodies for RBP4

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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RBP4 Gene at Home site.
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RBP4 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for RBP4

Summaries
for RBP4

Genomic Location
for RBP4

Proteins
for RBP4

Protein Domains/
Families
for RBP4

Gene Function
for RBP4

Pathways & Interactions
for RBP4

Drugs & Compounds
for RBP4

Transcripts
for RBP4

Expression
for RBP4

Orthologs
for RBP4

Paralogs
for RBP4

SNPs/Variants
for RBP4

Disorders & Mutations
for RBP4

Medical News
for RBP4

Publications
for RBP4

Search for RBP4

Genome Databases showing RBP4

Other Databases showing RBP4

Specialized Databases showing RBP4

Licensable Technologies
for RBP4

Services
for RBP4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RBP4 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor RBP4

Summariesfor RBP4

Genomic Locationfor RBP4

Proteinsfor RBP4

Protein Domains/Familiesfor RBP4

Gene Functionfor RBP4

Pathways & Interactionsfor RBP4

Drugs & Compoundsfor RBP4

Transcriptsfor RBP4

Expression for RBP4

Orthologsfor RBP4

Paralogsfor RBP4

SNPs/Variantsfor RBP4

Disorders & Mutationsfor RBP4

Medical Newsfor RBP4

Publicationsfor RBP4

Search for RBP4

Genome Databases showing RBP4

Other Databases showing RBP4

Specialized Databases showing RBP4

Licensable Technologiesfor RBP4

Servicesfor RBP4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RBP4

Summaries
for RBP4

Genomic Location
for RBP4

Proteins
for RBP4

Protein Domains/
Families
for RBP4

Gene Function
for RBP4

Pathways & Interactions
for RBP4

Drugs & Compounds
for RBP4

Transcripts
for RBP4

Expression
for RBP4

Orthologs
for RBP4

Paralogs
for RBP4

SNPs/Variants
for RBP4

Disorders & Mutations
for RBP4

Medical News
for RBP4

Publications
for RBP4

Licensable Technologies
for RBP4

Services
for RBP4