Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RBP4 Gene

protein-coding GIFtS: 64
GCID: GC10M095341

retinol binding protein 4, plasma

(Previous names: retinol-binding protein 4, plasma )

Explore 99 diseases affiliated with
RBP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Retinol Binding Protein 4, Plasma¹ ²		Retinol-Binding Protein 4, Plasma¹
Plasma Retinol-Binding Protein² ³		Retinol-Binding Protein 4²
PRBP² ³		Retinol-Binding Protein 4, Interstitial²
RBP² ³

External Ids:	HGNC: 9922¹	Entrez Gene: 5950²	Ensembl: ENSG00000138207⁷	OMIM: 180250⁵	UniProtKB: P02753³

Export aliases for RBP4 gene to outside databases

Previous GC identifers: GC10M094244 GC10M094585 GC10M095482 GC10M095016 GC10M088979

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBP4:

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood.

It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with

transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks

secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal

cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753

Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex

interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli

Gene Wiki entry for RBP4 (Retinol binding protein 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RBP4 gene promoter:
PPAR-gamma1 AP-2beta PPAR-gamma2 AP-2gamma AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RBP4 promoter sequence

Search SABiosciences Chromatin IP Primers for RBP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q23-q24

RBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBP4 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M095341: view genomic region (about GC identifiers)

Start:	95,351,444 bp from pter	End:	95,361,501 bp from pter
Size:	10,058 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753 (See protein sequence)

Recommended Name: Retinol-binding protein 4 precursor

Size: 201 amino acids; 23010 Da

Subcellular location: Secreted

Mass spectrometry: Mass=21063.46; Mass_error=1.88; Method=Electrospray; Range=17-199; Source=PubMed:7666002;

Mass spectrometry: Mass=20534; Method=MALDI; Range=19-197; Source=PubMed:12237133;

Mass spectrometry: Mass=20162; Method=MALDI; Range=19-194; Source=PubMed:12237133;

Sequence caution: Sequence=AAF69622.1; Type=Erroneous initiation;

6/12 PDB 3D structures from and Proteopedia for RBP4 (see all 12):

1BRP (3D)

1BRQ (3D)

1JYD (3D)

1JYJ (3D)

1QAB (3D)

1RBP (3D)

Secondary accessions: D3DR38 O43478 O43479 Q5VY24 Q8WWA3 Q9P178

Explore the universe of human proteins at neXtProt for RBP4: NX_P02753

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02753

RBP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006735.2

ENSEMBL proteins:

ENSP00000360519 ENSP00000360524 ENSP00000360522

Reactome Protein details: P02753
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for RBP4 (RBP4/Retinol-Binding Protein 4)
	Enzo Life Sciences proteins for RBP4
	OriGene Purified Protein: RBP4 OriGene Protein Over-expression Lysate: RBP4 OriGene Custom Protein Services for RBP4
	GenScript Custom Purified and Recombinant Proteins Services for RBP4
	Novus Biologicals RBP4 Proteins Novus Biologicals RBP4 Lysates
	Sino Biological Recombinant Protein for RBP4
	ProSpec Recombinant Protein for RBP4
	Uscn Proteins for RBP4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	ISS	--
GO:0043234	protein complex	IEA	--

RBP4 for ontologies About GeneDecksing

RBP4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for RBP4 (RBP4/Retinol-Binding Protein 4)
	OriGene Antibodies (see all 4): RBP4 OriGene Custom Antibody Services for RBP4
	GenScript Custom Superior Antibodies Services for RBP4
	Novus Biologicals RBP4 Antibodies
	Abcam antibodies for RBP4
	Uscn Antibodies for RBP4
	ThermoFisher Antibody for RBP4

Assay Products for RBP4:

	EMD Millipore Kits and Assays for the Analysis of RBP4
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for RBP4 (RBP4/Retinol-Binding Protein 4) (see all)
	GenScript Custom Assay Services for RBP4
	Enzo Life Sciences assays for RBP4
	Uscn ELISAs and CLIAs for RBP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RBP4 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR022271 Lipocalin_ApoD

IPR012674 Calycin

IPR011038 Calycin-like

IPR002345 Lipocalin

IPR022272 Lipocalin_CS

Graphical View of Domain Structure for InterPro Entry P02753

ProtoNet protein and cluster: P02753

2 Blocks protein families:

IPB002345 Lipocalin signature

IPB002449 Retinol binding protein signature

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753

Similarity: Belongs to the calycin superfamily. Lipocalin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753

Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex

interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli

Genatlas biochemistry entry for RBP4:

retinol binding protein 4,serum (lipocalin family,Kernel group),monomer,binding to transthyretin

miRNA Products:		OriGene 3'-UTR Clone: RBP4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBP4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate RBP4:
		hsa-miR-577 hsa-miR-3121-3p
		SwitchGear 3'UTR luciferase reporter plasmid: RBP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBP4 (see all 7) OriGene shRNA RFP: RBP4 OriGene siRNA: RBP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBP4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RBP4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBP4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBP4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RBP4 (NM_006744)
		Sino Biological Human cDNA Clone for RBP4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RBP4
		Search LifeMap BioReagents cell lines for RBP4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP4

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	--	--
GO:0005501	retinoid binding	--	--
GO:0005515	protein binding	IPI	986177
GO:0016918	retinal binding	IEA	--
GO:0019841	retinol binding	IDA	571335

RBP4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for RBP4: Rbp4^tm1.1Mma Rbp4^tm1Gott
     8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rbp4):

cardiovascular system	cellular	endocrine/exocrine gland	homeostasis/metabolism	muscle
normal	reproductive system	vision/eye

RBP4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

the visual cycle I (vertebrates)

	the visual cycle I (vertebrates)	1.00			The canonical retinoid cycle in rods (twilight vision)	0.50
	retinol biosynthesis	0.52

Defective STRA6 does not transport atROL

Defective STRA6 does not transport atROL

1.00

Defective RBP4 does not bind atROL

0.33

retinoate biosynthesis II

retinoate biosynthesis II

1.00

retinoate biosynthesis I

0.38

Disease

Disease

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for RBP4

Adipocytokines & Insulin Signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RBP4

Visual Cycle in Retinal Rods

5 BioSystems Pathways for RBP4

	Vitamin A and carotenoid metabolism
	retinoate biosynthesis I
	the visual cycle I (vertebrates)
	retinoate biosynthesis II
	retinol biosynthesis

5/9 Reactome Pathways for RBP4 (see all 9)

	Diseases associated with visual transduction
	Retinoid cycle disease events
	Retinoid metabolism and transport
	Defective RBP4 does not bind atROL
	Signal Transduction

RBP4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RBP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for RBP4 (P02753^{2, 3} ENSP00000360519⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TTR	P02766²^,³, ENSP00000237014⁴	MINT-8195884 I2D: score=4 STRING: ENSP00000237014
RBBP6	Q7Z6E9³, ENSP00000317872⁴	I2D: score=1 STRING: ENSP00000317872
ALB	P02768³, ENSP00000295897⁴	I2D: score=1 STRING: ENSP00000295897
RPE65	Q16518³, ENSP00000262340⁴	I2D: score=1 STRING: ENSP00000262340
GRB2	P62993³, ENSP00000339007⁴	I2D: score=2 STRING: ENSP00000339007

About this table

Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001654	eye development	ISS	--
GO:0006094	gluconeogenesis	ISS	--
GO:0007283	spermatogenesis	IEA	--
GO:0007507	heart development	ISS	--
GO:0008584	male gonad development	IEA	--

RBP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RBP4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RBP4

5 DrugBank Compounds for RBP4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vitamin A	[11,12-3H]-Retinol (see all 18)	68-26-8	carrier	--	16181461 16150442 17529981 17001693 17566551
All-Trans Axerophthene	--	--	carrier	--	17139284 17016423 10592235
Fenretinide	4-HPR (see all 3)	65646-68-6	carrier	--	17139284 17016423 10592235
N-Ethyl Retinamide	--	--	carrier	--	17139284 17016423 10592235
2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid	--	--	carrier	--	10592235

10/74 Novoseek chemical compound relationships for RBP4 gene (see all 74) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin a	94.8	1619	18641048 (9), 14749226 (9), 18426837 (9), 11237937 (9) (see all 99)
retinyl palmitate	65.6	6	8604659 (2), 18952041 (1), 7551819 (1), 2108233 (1)
retinoid	63.5	27	15314099 (2), 7586162 (2), 15757863 (2), 1386578 (1) (see all 17)
n-4-methoxyphenylretinamide	62.1	2	7586162 (1), 2140925 (1)
creatinine	58.4	101	11248475 (4), 9614399 (4), 9367006 (3), 1790129 (2) (see all 48)
retinyl ester	54.2	2	8290933 (2)
glucose	53.4	230	19506831 (6), 18430770 (5), 19766271 (5), 19190263 (5) (see all 71)
retinoic acid	52.2	36	16101150 (3), 19015161 (3), 10199796 (2), 8408080 (2) (see all 19)
betacarotene	51.1	16	8926532 (2), 18209407 (2), 19255795 (2), 15379913 (1) (see all 12)
purpurin	49.9	4	1601873 (2), 1915658 (1)

Search CenterWatch for drugs/clinical trials and news about RBP4 / RET4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RBP4 gene:

NM_006744.3

Unigene Cluster for RBP4:

Retinol binding protein 4, plasma

Hs.50223 [show with all ESTs]

Unigene Representative Sequence: BQ064708

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371464(uc001kit.3) ENST00000371469 ENST00000371467 ENST00000471469

ENST00000471333

miRNA Products:		OriGene 3'-UTR Clone: RBP4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBP4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate RBP4:
		hsa-miR-577 hsa-miR-3121-3p
		SwitchGear 3'UTR luciferase reporter plasmid: RBP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBP4 (see all 7) OriGene shRNA RFP: RBP4 OriGene siRNA: RBP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBP4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBP4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBP4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RBP4 (NM_006744)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RBP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBP4

Additional cDNA sequence:

BC020633.1 X00129.1

11 DOTS entries:

DT.449609 DT.101987968 DT.95269390 DT.121212756 DT.108214 DT.95269391 DT.100740972 DT.95269382

DT.121212750 DT.91783506 DT.95269381

24/276 AceView cDNA sequences (see all 276):

CA843636 CA866827 CA843571 AV648275 BX496564 BP346757 C00760 CA772163

AV652752 CA771937 H21451 H28527 BE348621 AI983588 H26422 CA776212

AV682742 CA844219 AV648544 AV662271 CA867042 BU077944 H25489 CB153368

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RBP4 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9
SP1:																	-
SP2:																	-
SP3:			-		-
SP4:																	-				-
SP5:

ECgene alternative splicing isoforms for RBP4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RBP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGCACCT

About this image

RBP4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Heart

Cardiac Crescent

Cardiac Crescent Cells

Myocardium

Limb

Forelimb Myotome

Limb Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

White adipocyte-like cells (Differentiation of ...)

Adipose

See RBP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBP4

SOURCE GeneReport for Unigene cluster: Hs.50223

SABiosciences Expression via Pathway-Focused PCR Arrays including RBP4:

Insulin Resistance in human mouse rat

Fatty Liver in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RBP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBP4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RBP4 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rbp4^{1 , 5}	retinol binding protein 4, plasma^{1, 5}	85.24(n)¹ 85.57(a)¹		19 (32.75 cM)⁵ 19662¹ NM_001159487.1¹ NP_001152959.1¹ 38116620⁵
chicken (Gallus gallus)	Aves	RBP4¹	retinol binding protein 4, plasma	76.04(n) 84.37(a)		396166 NM_205238.1 NP_990569.1
lizard (Anolis carolinensis)	Reptilia	RBP4⁶	--	68(a)	1 ↔ 1	GL343219.1(1917897-1927414)
African clawed frog (Xenopus laevis)	Amphibia	rbp4-prov²	retinol binding protein 4, plasma	74.22(n)		BC044674.1
zebrafish (Danio rerio)	Actinopterygii	rbp4²	retinol binding protein 4, plasma	73.68(n)		30077 AJ236884.1

ENSEMBL Gene Tree for RBP4 (if available)
TreeFam Gene Tree for RBP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112666890^1,2	C	--	88979632(+)	`AACCTC/G/TGAAAA`	1	--	int¹		1	CSA	1
rs76999824^1,2	C,F,	--	88979710(+)	`GCCTTA/GGAGCT`	1	--	int¹		1	WA	118
rs13376835^1,2	C,F,A,H,	--	88979933(+)	`GTCGGA/GGGCCA`	1	--	int¹		24	NS EA NA WA CSA	2354
rs17108990^1,2	C,F,	--	88980001(+)	`GGTTTT/CATAAA`	1	--	int¹		4	NA	144
rs115120975^1,2	C,F,	--	88980031(+)	`CATGTG/ATCACC`	1	--	int¹		1	WA	118
rs11187542^1,2	H,	--	88980199(+)	`GTGGTG/AGAATC`	1	--	int¹		5	NS EA WA NA	528
rs77196820^1,2	C,F,	--	88980218(+)	`CCCTAC/TATTTA`	1	--	int¹		1	WA	118
rs73327272^1,2	C,	--	88980300(+)	`AGTTCG/ATGACC`	1	--	int¹		1	WA	2
rs55964695^1,2	C,F,	--	88980342(+)	`TTATTA/TTTATT`	1	--	int¹		5	NA WA	244
rs7079946^1,2	C,F,A,H,	--	88980345(+)	`TTATTA/TTTTTT`	1	--	int¹		9	NS EA NA WA	778

HapMap Linkage Disequilibrium report for RBP4 (95351444 - 95361501 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBP4: --
Human Gene Mutation Database (HGMD): RBP4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBP4

DNA2.0 Custom Variant and Variant Library Synthesis for RBP4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RBP4 for disorders About GeneDecksing

OMIM gene information: 180250 OMIM disorders: --

UniProtKB/Swiss-Prot: RET4_HUMAN, P02753

Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This

condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy

of the retinal pigment epithelium

20/99 diseases for RBP4 (see all 99): About MalaCards

retinol binding protein protein-energy malnutrition pseudotumor cerebri diffuse idiopathic skeletal hyperostosis

hypervitaminosis a glucose intolerance transthyretin amyloidosis polycystic ovary syndrome

plasmodium falciparum malaria hyperostosis bronchopulmonary dysplasia diabetes mellitus

type 2 diabetes mellitus glycogen storage disease type 1 diabetes mellitus iron overload

lupus nephritis chronic obstructive pulmonary disease lupus erythematosus sleep apnea

2 diseases from the University of Copenhagen DISEASES database for RBP4:

Diabetes mellitus Fatty liver disease

10/81 Novoseek disease relationships for RBP4 gene (see all 81) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin a deficiency	82.8	32	14749226 (3), 19568486 (3), 16702331 (2), 1493768 (1) (see all 19)
insulin resistance	79.7	439	18390799 (7), 18588869 (7), 19766271 (6), 18641048 (5) (see all 99)
insulin sensitivity	68.6	77	18239568 (5), 17405846 (3), 18430770 (3), 17294166 (3) (see all 32)
hypervitaminosis a	63.5	1	1517032 (1)
obesity	55.7	122	17341558 (4), 19501863 (3), 16034410 (3), 17656599 (3) (see all 45)
albuminuria	55	11	12702785 (2), 18973209 (2), 19839150 (1), 2250610 (1) (see all 6)
proximal renal tubular dysfunction	54.3	1	8084448 (1)
proteinuria	52.4	18	10620205 (5), 8084448 (2), 8448868 (2), 1379421 (1) (see all 11)
protein-energy malnutrition	52.2	1	11470636 (1)
microalbuminuria	50.9	15	17568782 (4), 19506831 (4), 15016173 (2), 18973209 (2) (see all 7)

Genatlas disease: RBP4

night blindness and progressive atrophy of the retinal pigment epithelium,autosomal recessive,with retinol binding

protein 4 deficiency

Human Genome Epidemiology (HuGE) Navigator: RBP4 (14 documents)

Export disorders for RBP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RBP4 gene, integrated from 9 sources (see all 705):
(articles sorted by number of sources associating them with RBP4)

Utopia: connect your pdf to the dynamic
world of online information

The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. (PubMed id 10052934)^{1, 2, 9} Naylor H.M. and Newcomer M.E. (1999)
Comparative urine protein phenotyping using mass spectrometric immunoassay. (PubMed id 12716133)^{1, 2, 9} Kiernan U.A.... Nelson R.W. (2003)
Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure. (PubMed id 7666002)^{1, 2, 9} Jaconi S.... Siegenthaler G. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Comparative phenotypic analyses of human plasma and urinary retinol binding protein using mass spectrometric immunoassay. (PubMed id 12237133)^{1, 2} Kiernan U.A.... Nelson R.W. (2002)
Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. (PubMed id 9888420)^{1, 2} Seeliger M.W.... Zrenner E. (1999)
Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. (PubMed id 10232633)^{1, 2} Biesalski H.K.... Zrenner E. (1999)
Three-dimensional structure and active site of three hydrophobic molecule-binding proteins with significant amino acid sequence similarity. (PubMed id 1623143)^{1, 2} Monaco H.L. and Zanotti G. (1992)
Crystallographic refinement of human serum retinol binding protein at 2-A resolution. (PubMed id 2217163)^{1, 2} Cowan S.W.... Jones T.A. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5950	HGNC: 9922	AceView: RBP4	Ensembl:ENSG00000138207	euGenes: HUgn5950
ECgene: RBP4	H-InvDB: RBP4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RBP4	Pharmacogenomics, SNPs, Pathways
Mutations of the RBP4 gene	http://www.retina-international.org/files/sci-news/rlbp4mut.htm
Wikipedia	http://en.wikipedia.org/wiki/Retinol_binding_protein_4

Intellectual Property for RBP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RBP4 gene:
Search GeneIP for patents involving RBP4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	EMD Millipore Kits and Assays for the Analysis of RBP4
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for RBP4 (RBP4/Retinol-Binding Protein 4)		Browse Cell Culture Products
	ELISAs for RBP4 (RBP4/Retinol-Binding Protein 4)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for RBP4 (RBP4/Retinol-Binding Protein 4)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for RBP4 (RBP4/Retinol-Binding Protein 4)

	OriGene Antibodies for RBP4		OriGene shRNA RFP for RBP4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBP4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBP4
	OriGene Protein Over-expression Lysate for RBP4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RBP4		OriGene 3'-UTR Clone for RBP4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBP4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBP4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for RBP4		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RBP4		OriGene Custom Protein Services for RBP4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBP4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBP4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBP4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBP4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBP4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBP4

	GenScript Custom Purified and Recombinant Proteins Services for RBP4		GenScript cDNA clones with any tag delivered in your preferred vector for RBP4
	GenScript Custom Assay Services for RBP4		GenScript Custom Superior Antibodies Services for RBP4
	GenScript Custom overexpressing Cell Line Services for RBP4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RBP4 promoter
	Search Chromatin IP Primers for RBP4
	RT² qPCR Primer Assay in human, mouse, rat RBP4
	GNC Network for RBP4
	SABiosciences PCR Arrays including human, mouse, rat RBP4

Search Tocris compounds for RBP4

	Proteins and Antibodies for RBP4
	cDNA Clones for RBP4
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays/Proteins for RBP4
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RBP4 antibodies
	RBP4 proteins
	RBP4 lysates

	Antibodies for RBP4
	See all of Abcam's Antibodies, Kits and Proteins for RBP4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for RBP4

RBP4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RBP4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP4

	SwitchGear 3'UTR luciferase reporter plasmids for RBP4
	SwitchGear Promoter luciferase reporter plasmids for RBP4

ThermoFisher Antibody for RBP4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RBP4 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RBP4 Gene

retinol binding protein 4, plasma

Aliases
for RBP4 gene

Summaries
for RBP4 gene

Genomic Views
for RBP4 gene

Proteins
for RBP4 gene

Protein Domains /
Families
for RBP4 gene

Function
for RBP4 gene

Pathways & Interactions
for RBP4 gene

Drugs & Compounds
for RBP4 gene

Transcripts
for RBP4 gene

Expression
for RBP4 gene

Orthologs
for RBP4 gene

Paralogs
for RBP4 gene

Genomic Variants
for RBP4 gene

Disorders / Diseases
for RBP4 gene

Publications
for RBP4 gene

External Searches for RBP4 gene

Genome Databases showing RBP4 gene

Other Databases showing RBP4 gene

Specialized Databases showing RBP4 gene

Intellectual Property
for RBP4 gene

Products
for RBP4 gene

View Random Gene

Fatty Liver
Microalbuminuria
Protein-Energy Malnutrition
Measles
Nephritis
preterm delivery
Hyperinsulinemia
Hypervitaminosis A
Hepatitis Chronic
sepsis
Malaria
Vitamin A Deficiency
Cystic Fibrosis
Pseudotumor Cerebri
Glucose Intolerance
insulin sensitivity
Polyneuropathy
Liver diseases
PROTEIN MALNUTRITION
Atherosclerosis
Intoxication
Breast Cancer
Hypercholesterolemia
Nephrotic Syndrome
Cholestasis
Amyloidosis
cell damage
Cancer
Diabetes Mellitus Insulin-Dependent
Bronchopulmonary Dysplasia
Lymphoma
Dyslipidemia
RENAL DISEASE
Ovarian Cancer
Malnutrition
Inflammation
Diabetic Nephropathies
GLOMERULOSCLEROSIS, FOCAL SEGMENTAL
Proteinuria
Malaria Falciparum
Cysts
Renal Failure
LIVER DAMAGE
Pneumonia
Hyperostosis Diffuse Idiopathic Skeletal
Cardiovascular Diseases
Tumors
Liver Cirrhosis
Necrosis
Renal Failure Acute
Hepatitis C
Cirrhosis
Critically Ill
Carcinoma
Diabetes Gestational
retinopathy
Leukemia
Alzheimers Disease
Diabetes Mellitus
HEPATOCELLULAR CARCINOMA
Hypersensitivity Delayed
Cancer Lung
Albuminuria
HEART FAILURE
Response Acute Phase
Insulin Resistance
impaired glucose tolerance
OBESITY
Polycystic Ovary Syndrome
Lung diseases
ZINC DEFICIENCY
Histopathology
KIDNEY DYSFUNCTION
Proximal Renal Tubular Dysfunction
Lupus Nephritis
chronic liver disease
Glomerulonephritis
NIDDM
Urinary Stones
Lupus Erythematosus Systemic
Renal Failure Chronic

Advanced Search

Export list of displayed genes

RBP4 Gene

retinol binding protein 4, plasma

Aliasesfor RBP4 gene

Summariesfor RBP4 gene

Genomic Viewsfor RBP4 gene

Proteinsfor RBP4 gene

Protein Domains /Familiesfor RBP4 gene

Functionfor RBP4 gene

Pathways & Interactionsfor RBP4 gene

Drugs & Compoundsfor RBP4 gene

Transcriptsfor RBP4 gene

Expression for RBP4 gene

Orthologsfor RBP4 gene

Paralogsfor RBP4 gene

Genomic Variantsfor RBP4 gene

Disorders / Diseasesfor RBP4 gene

Publicationsfor RBP4 gene

External Searches for RBP4 gene

Genome Databases showing RBP4 gene

Other Databases showing RBP4 gene

Specialized Databases showing RBP4 gene

Intellectual Propertyfor RBP4 gene

Productsfor RBP4 gene

View Random Gene

Aliases
for RBP4 gene

Summaries
for RBP4 gene

Genomic Views
for RBP4 gene

Proteins
for RBP4 gene

Protein Domains /
Families
for RBP4 gene

Function
for RBP4 gene

Pathways & Interactions
for RBP4 gene

Drugs & Compounds
for RBP4 gene

Transcripts
for RBP4 gene

Expression
for RBP4 gene

Orthologs
for RBP4 gene

Paralogs
for RBP4 gene

Genomic Variants
for RBP4 gene

Disorders / Diseases
for RBP4 gene

Publications
for RBP4 gene

Intellectual Property
for RBP4 gene

Products
for RBP4 gene