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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RBP3 Gene

protein-coding GIFtS: 55
GCID: GC10M048381

retinol binding protein 3, interstitial

(Previous names: retinol-binding protein 3, interstitial )

Explore 27 diseases affiliated with
RBP3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Retinol Binding Protein 3, Interstitial¹ ²		IRBP² ³
D10S64¹ ²		Retinol-Binding Protein 3, Interstitial¹
D10S65¹ ²		RBPI²
D10S66¹ ²		Retinol-Binding Protein 3²
Interphotoreceptor Retinoid-Binding Protein² ³		Interstitial Retinol-Binding Protein³

External Ids:	HGNC: 9921¹	Entrez Gene: 5949²	Ensembl: ENSG00000107618⁷	OMIM: 180290⁵	UniProtKB: P10745³

Export aliases for RBP3 gene to outside databases

Previous GC identifers: GC10P047549 GC10P047678 GC10M048317 GC10M047776 GC10M048001 GC10M043133

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBP3:

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the

interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is

thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the

visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three

introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an

approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino

acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a

series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron

junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the

first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three

exons, which are 191, 143, and approximately 740 base pairs long, respectively. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RET3_HUMAN, P10745

Function: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the

visual pigments in the photoreceptor cells of the retina

Gene Wiki entry for RBP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030772.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RBP3 gene promoter:
SRF SRF (504 AA) SREBP-1c LCR-F1 Evi-1 YY1 E47 SREBP-1b SREBP-1a ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RBP3 promoter sequence

Search SABiosciences Chromatin IP Primers for RBP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.2

RBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBP3 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M048381: view genomic region (about GC identifiers)

Start:	48,381,487 bp from pter	End:	48,390,991 bp from pter
Size:	9,505 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RET3_HUMAN, P10745 (See protein sequence)

Recommended Name: Retinol-binding protein 3 precursor

Size: 1247 amino acids; 135363 Da

Subcellular location: Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.

Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment

epithelium cells

Caution: It is uncertain whether Met-1 or Met-2 is the initiator

Sequence caution: Sequence=AAC18875.1; Type=Erroneous initiation;

Secondary accessions: Q5VSR0

Explore the universe of human proteins at neXtProt for RBP3: NX_P10745

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10745

RBP3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002891.1

ENSEMBL proteins:

ENSP00000224600

Reactome Protein details: P10745
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	Uscn Proteins for RBP3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0033165	interphotoreceptor matrix	IEA	--

RBP3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RBP3 for domains About GeneDecksing

3 InterPro domains/families:

IPR024591 Interphotorcpt_retinol-bd_N

IPR005151 Interphotoreceptor_retinol-bd

IPR024070 Tricorn_prtase_C1_dom

Graphical View of Domain Structure for InterPro Entry P10745

ProtoNet protein and cluster: P10745

UniProtKB/Swiss-Prot: RET3_HUMAN, P10745

Similarity: Belongs to the peptidase S41A family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RET3_HUMAN, P10745

Function: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the

visual pigments in the photoreceptor cells of the retina

Genatlas biochemistry entry for RBP3:

retinol binding protein 3,133kDa,interstitial,matrix of the retina (includes D10S64,D10S65,D10S66) (lipocalin

family,Kernel group),monomer

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		hsa-miR-4291 hsa-miR-214 hsa-miR-761 hsa-miR-3670
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Gene Editing
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In Situ Assay
Products:

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Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005501	retinoid binding	TAS	2542268
GO:0008236	serine-type peptidase activity	--	--
GO:0016918	retinal binding	IEA	--
GO:0070008	serine-type exopeptidase activity	IEA	--

RBP3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Rbp3^tm1Gil for RBP3
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rbp3):

nervous system

vision/eye

RBP3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

11cRAL (RPE) translocates to photoreceptor outer segment

	11cRAL (RPE) translocates to photoreceptor outer segment	1.00			11cROL translocates from Muller cells to cone photoreceptor cells	0.50
	RBP3 regulates atROL taken up by Muller cells	0.50			RBP3 regulates the transport of atROL from ROS to RPE	0.50

the visual cycle I (vertebrates)

the visual cycle I (vertebrates)

1.00

The canonical retinoid cycle in rods (twilight vision)

0.50

Retinoid metabolism and transport

Visual phototransduction

0.74

Diseases associated with visual transduction

0.73

Disease

Disease

1.00

Visual Cycle in Retinal Rods

Visual Cycle in Retinal Rods

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RBP3

Visual Cycle in Retinal Rods

1 BioSystems Pathway for RBP3

the visual cycle I (vertebrates)

5/10 Reactome Pathways for RBP3 (see all 10)

	Diseases associated with visual transduction
	The retinoid cycle in cones (daylight vision)
	11cROL translocates from Muller cells to cone photoreceptor cells
	The canonical retinoid cycle in rods (twilight vision)
	RBP3 regulates the transport of atROL from ROS to RPE

RBP3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RBP3

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for RBP3 (P10745³ ENSP00000224600⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NOTCH1	P46531³, ENSP00000277541⁴	I2D: score=1 STRING: ENSP00000277541
RB1	ENSP00000267163⁴	STRING: ENSP00000267163
TFDP1	ENSP00000364519⁴	STRING: ENSP00000364519
TFDP2	ENSP00000309622⁴	STRING: ENSP00000309622
MCPH1	ENSP00000342924⁴	STRING: ENSP00000342924

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0006629	lipid metabolic process	TAS	2542268
GO:0006810	transport	IEA	--
GO:0007601	visual perception	TAS	2542268

RBP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RBP3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RBP3

1 DrugBank Compound for RBP3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vitamin A	[11,12-3H]-Retinol (see all 18)	68-26-8	target	--	17200663 15928609 17049961 15935345 17602665

10/15 Novoseek chemical compound relationships for RBP3 gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoid	87.3	157	8318167 (4), 11161734 (4), 10756179 (3), 1606838 (2) (see all 69)
vitamin a	72	85	7835405 (8), 10655150 (7), 8218196 (4), 7924403 (3) (see all 31)
11-cis-retinol	67.9	3	14718298 (1), 15928609 (1)
retinaldehyde	54.3	7	10800207 (1), 10655150 (1), 15928609 (1)
docosahexaenoic acid	31.9	3	8218196 (1), 9374503 (1)
retinoic acid	20.4	11	11394872 (3), 14611939 (1), 10800207 (1), 8752109 (1)
fatty acid	5.97	11	8466918 (4), 10756179 (1), 8318167 (1), 8218196 (1) (see all 5)
chloramphenicol	3.29	4	11597600 (1), 2160453 (1), 9723991 (1)
butyrate	0.902	5	11934446 (3)
nitric oxide	0	1	11710518 (1)

Search CenterWatch for drugs/clinical trials and news about RBP3 / RET3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RBP3 gene:

NM_002900.2

Unigene Cluster for RBP3:

Retinol binding protein 3, interstitial

Hs.591928 [show with all ESTs]

Unigene Representative Sequence: NM_002900

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000224600(uc001jez.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBP3
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate RBP3:
		hsa-miR-4291 hsa-miR-214 hsa-miR-761 hsa-miR-3670
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Additional cDNA sequence:

AB593121.1 BC039844.1 DQ426897.1 J03912.1 M22453.1

2 DOTS entries:

DT.413025 DT.208339

24/70 AceView cDNA sequences (see all 70):

BU728989 BM709524 M22453 BQ186801 BM709691 BU154221 AA364117 BU733630

BQ638569 BM663490 BM709167 BM727494 BQ640598 BQ637660 BC039844 BQ637586

BQ638458 BM661512 BU732226 BU726616 J03912 BM716277 BU728529 NM_002900

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RBP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATACACA

About this image

RBP3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Retinal progenitor-like cells (Generation of retina...)

Photoreceptor-like cells (Generation of retina...)

See RBP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBP3

SOURCE GeneReport for Unigene cluster: Hs.591928

SABiosciences Custom PCR Arrays for RBP3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RBP3 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rbp3^{1 , 5}	retinol binding protein 3, interstitial^{1, 5}	82.34(n)¹ 85.6(a)¹		14 (20.80 cM)⁵ 19661¹ NM_015745.2¹ NP_056560.1¹ 33954022⁵
chicken (Gallus gallus)	Aves	RBP3¹	retinol binding protein 3, interstitial	66.67(n) 66.5(a)		395553 NM_001024575.1 NP_001019746.1
lizard (Anolis carolinensis)	Reptilia	RBP3⁶	--	60(a)	1 ↔ 1	GL343297.1(527844-543976)
zebrafish (Danio rerio)	Actinopterygii	LOC794630¹	retinol-binding protein 3-like	52.23(n) 45.19(a)		794630 XM_001334600.4 XP_001334636.2

ENSEMBL Gene Tree for RBP3 (if available)
TreeFam Gene Tree for RBP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146150511^1,2	C	untested	43138335(+)	`CATGTC/TGATGA`	2	N D	mis¹		1		NA	4552
rs58627053^1,2		--	43133998(+)	`TTTATC/TTTCTT`	1	--	ut3¹		0	--	--	--	--
rs79612534^1,2		--	43135589(+)	`TGAACG/ATATGT`	1	--	int¹		1		EA	120
rs2607866^1,2	C	--	43136648(-)	`ACTAGG/TACTCT`	1	--	int¹		0	--	--	--	--
rs79030240^1,2	F,	--	43137248(+)	`TTAGCA/GTGAGT`	1	--	int¹		1		WA	118
rs75925806^1,2	F,	--	43137514(+)	`CAACAC/TGGGAG`	1	--	int¹		1		WA	118
rs17095795^1,2	C,F,H,	--	43137589(+)	`TGGACC/GCCAGA`	1	--	int¹		10		NA NS EA WA	682
rs114096589^1,2	C,F,	--	43139451(+)	`CACCCG/ATAGCT`	1	--	int¹		1		WA	118
rs75363941^1,2	F,	--	43139561(+)	`GAGGGC/TTATGC`	1	--	int¹		1		EA	120
rs9421729^1,2	C,F,H,	--	43139684(+)	`AGTAAC/TCGCCT`	1	--	int¹		8		NS EA NA	824

HapMap Linkage Disequilibrium report for RBP3 (48381487 - 48390991 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RBP3
5 CNVs: 2863 70986 30490 31728 3798
Human Gene Mutation Database (HGMD): RBP3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBP3

DNA2.0 Custom Variant and Variant Library Synthesis for RBP3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RBP3 for disorders           About GeneDecksing

OMIM gene information: 180290    OMIM disorders: --

20/27 diseases for RBP3 (see all 27):    About MalaCards

retinol binding protein retinitis retinoblastoma retinitis punctata albescens

hypersensitivity reaction type ii disease fundus albipunctatus onchocerciasis posterior uveitis

proliferative vitreoretinopathy chorioretinitis retinitis pigmentosa night blindness

coats disease sipple syndrome eales disease cerebellar medulloblastoma

uveitis retinal degeneration behcet's disease diphtheria

2 diseases from the University of Copenhagen DISEASES database for RBP3:

Uveitis Retinal degeneration

10/24 Novoseek disease relationships for RBP3 gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
uveitis	86.4	55	2091897 (3), 20089879 (3), 9129978 (2), 8935743 (2) (see all 30)
onchocerciasis ocular	79.4	1	2365568 (1)
retinoblastoma	69.2	21	11597600 (4), 8115118 (2), 11134581 (2), 11301407 (2) (see all 10)
pineal tumors	65.8	4	8360704 (2)
autoimmune response	62.7	5	2365568 (1), 2378211 (1), 1936175 (1), 2200648 (1)
retinitis pigmentosa	57.3	14	1974891 (3), 1577290 (1), 7474803 (1), 17963276 (1) (see all 5)
chorioretinitis	55.6	2	2378211 (2)
autoimmunity	55.4	2	18266969 (1), 16585264 (1)
retinal degeneration	52.3	5	8001085 (2), 19074801 (1), 1936175 (1)
autoimmune diseases	50.8	6	1424752 (1), 8393049 (1), 16899371 (1), 10903340 (1)

Human Genome Epidemiology (HuGE) Navigator: RBP3 (5 documents)

Export disorders for RBP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RBP3 gene, integrated from 9 sources (see all 233):
(articles sorted by number of sources associating them with RBP3)

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Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene. (PubMed id 2402443)^{1, 2, 9} Albini A.... Noonan D.M. (1990)
Characterization and comparative structural features of the gene for human interstitial retinol-binding protein. (PubMed id 2303470)^{1, 2, 9} Fong S.-L.... Bridges C.D.B. (1990)
Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences. (PubMed id 2792773)^{1, 2} Si J.S.... Nickerson J.M. (1989)
Human interstitial retinoid-binding protein. Gene structure and primary structure. (PubMed id 2542268)^{1, 2} Liou G.I.... Baehr W. (1989)
Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA. (PubMed id 3170584)^{1, 2} Fong S.-L. and Bridges C.D.B. (1988)
Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization. (PubMed id 3455009)^{1, 2} Liou G.I....Bridges C.D.B. (1987)
N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species. (PubMed id 3743780)^{1, 2} Fong S.-L....Bridges C.D.B. (1986)
Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Similarities and differences as adjudged by peptide mapping and N-terminal sequencing. (PubMed id 3827838)^{1, 2} Redmond T.M.... Chader G.J. (1986)
Interphotoreceptor retinoid-binding protein (IRBP) is downregulated at early stages of diabetic retinopathy. (PubMed id 19823802)^{1, 9} Garcia-RamA-rez M....SimA^ R. (2009)
A homozygous missense mutation in the IRBP gene (RBP3) associated with autosomal recessive retinitis pigmentosa. (PubMed id 19074801)^{1, 9} den Hollander A.I....Berson E.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5949	HGNC: 9921	AceView: RBP3	Ensembl:ENSG00000107618	euGenes: HUgn5949
ECgene: RBP3	H-InvDB: RBP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RBP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RBP3 gene
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Patent Information for RBP3 gene:
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retinol binding protein 3, interstitial

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