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Aliases for RBP2 Gene

Aliases for RBP2 Gene

  • Retinol Binding Protein 2 2 3 5
  • Cellular Retinol-Binding Protein II 3 4
  • CRBP-II 3 4
  • CRBP2 3 4
  • Retinol-Binding Protein 2, Cellular 2
  • Retinol Binding Protein 2, Cellular 3
  • Retinol-Binding Protein 2 3
  • CRABP-II 3
  • CRBPII 3
  • RBPC2 3

External Ids for RBP2 Gene

Previous GeneCards Identifiers for RBP2 Gene

  • GC03M136069
  • GC03M140000
  • GC03M140453
  • GC03M140492
  • GC03M140654
  • GC03M139171
  • GC03M136547

Summaries for RBP2 Gene

Entrez Gene Summary for RBP2 Gene

  • This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]

GeneCards Summary for RBP2 Gene

RBP2 (Retinol Binding Protein 2) is a Protein Coding gene. Diseases associated with RBP2 include Mixed Germ Cell Cancer. Among its related pathways are Metabolism of fat-soluble vitamins and the visual cycle I (vertebrates). GO annotations related to this gene include transporter activity and retinal binding. An important paralog of this gene is RBP7.

UniProtKB/Swiss-Prot for RBP2 Gene

  • Intracellular transport of retinol.

Gene Wiki entry for RBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP2 Gene

Genomics for RBP2 Gene

Regulatory Elements for RBP2 Gene

Enhancers for RBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G139471 1 ENCODE dbSUPER 0.4 +5.6 5595 6.9 FOXA2 BACH1 ZNF175 CEBPG RARA FOSL1 NR2F6 FOS NFE2 TRIM24 ENSG00000272656 ACTG1P1 MRPS22 PIR34695 RBP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBP2 Gene

Chromosome:
3
Start:
139,452,884 bp from pter
End:
139,480,747 bp from pter
Size:
27,864 bases
Orientation:
Minus strand

Genomic View for RBP2 Gene

Genes around RBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP2 Gene

Proteins for RBP2 Gene

  • Protein details for RBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50120-RET2_HUMAN
    Recommended name:
    Retinol-binding protein 2
    Protein Accession:
    P50120
    Secondary Accessions:
    • A8K7G3
    • Q6ISQ9
    • Q6ISS7

    Protein attributes for RBP2 Gene

    Size:
    134 amino acids
    Molecular mass:
    15707 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP2 Gene

neXtProt entry for RBP2 Gene

Post-translational modifications for RBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RBP2 Gene

Domains & Families for RBP2 Gene

Gene Families for RBP2 Gene

Suggested Antigen Peptide Sequences for RBP2 Gene

Graphical View of Domain Structure for InterPro Entry

P50120

UniProtKB/Swiss-Prot:

RET2_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP2: view

Function for RBP2 Gene

Molecular function for RBP2 Gene

GENATLAS Biochemistry:
retinol binding protein 2,cellular (lipocalin family,Kernel group),monomer,involved in the transport of vitamin A in the small intestinal epithelium
UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.

Gene Ontology (GO) - Molecular Function for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding TAS 7657783
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP2: view
genes like me logo Genes that share phenotypes with RBP2: view

Animal Models for RBP2 Gene

MGI Knock Outs for RBP2:

Animal Model Products

miRNA for RBP2 Gene

miRTarBase miRNAs that target RBP2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBP2 Gene

Localization for RBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBP2 gene
Compartment Confidence
cytosol 5
peroxisome 2
nucleus 2
golgi apparatus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RBP2: view

Pathways & Interactions for RBP2 Gene

genes like me logo Genes that share pathways with RBP2: view

Gene Ontology (GO) - Biological Process for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006776 vitamin A metabolic process IEA --
GO:0006810 transport IEA --
GO:0008544 epidermis development TAS 1654334
genes like me logo Genes that share ontologies with RBP2: view

No data available for SIGNOR curated interactions for RBP2 Gene

Drugs & Compounds for RBP2 Gene

(2) Drugs for RBP2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Carrier 492

(8) Additional Compounds for RBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RBP2: view

Transcripts for RBP2 Gene

mRNA/cDNA for RBP2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBP2 Gene

Retinol binding protein 2, cellular:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBP2 Gene

No ASD Table

Relevant External Links for RBP2 Gene

GeneLoc Exon Structure for
RBP2
ECgene alternative splicing isoforms for
RBP2

Expression for RBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBP2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x51.1).

Protein differential expression in normal tissues from HIPED for RBP2 Gene

This gene is overexpressed in Fetal gut (59.0) and Pancreatic juice (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBP2 Gene



Protein tissue co-expression partners for RBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBP2 Gene:

RBP2

SOURCE GeneReport for Unigene cluster for RBP2 Gene:

Hs.655516

mRNA Expression by UniProt/SwissProt for RBP2 Gene:

P50120-RET2_HUMAN
Tissue specificity: Higher expression in adult small intestine and to a much lesser extent in fetal kidney.

Evidence on tissue expression from TISSUES for RBP2 Gene

  • Intestine(4.6)
genes like me logo Genes that share expression patterns with RBP2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RBP2 Gene

Orthologs for RBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBP2 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia RBP2 34 35
  • 89.3 (n)
cow
(Bos Taurus)
Mammalia RBP2 34 35
  • 88.31 (n)
rat
(Rattus norvegicus)
Mammalia Rbp2 34
  • 87.06 (n)
mouse
(Mus musculus)
Mammalia Rbp2 34 16 35
  • 86.82 (n)
oppossum
(Monodelphis domestica)
Mammalia RBP2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBP2 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBP2 34 35
  • 72.89 (n)
lizard
(Anolis carolinensis)
Reptilia RBP2 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbp2 34
  • 74.38 (n)
Str.15607 34
zebrafish
(Danio rerio)
Actinopterygii rbp2a 34 35
  • 74.13 (n)
rbp2 34
Species where no ortholog for RBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP2 Gene

ENSEMBL:
Gene Tree for RBP2 (if available)
TreeFam:
Gene Tree for RBP2 (if available)

Paralogs for RBP2 Gene

Paralogs for RBP2 Gene

(14) SIMAP similar genes for RBP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBP2: view

Variants for RBP2 Gene

Sequence variations from dbSNP and Humsavar for RBP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000026569 -- 139,469,271(+) CAGAA(A/G)ACACA intron-variant
rs1000188982 -- 139,468,423(+) TCAAT(A/C)TTTCT intron-variant
rs1000386666 -- 139,474,955(+) CCTCC(C/G)AACTA intron-variant
rs1000410119 -- 139,467,677(+) TGCAC(A/C)TTGCC intron-variant
rs1000453712 -- 139,456,544(+) AGTGT(A/G)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBP2 Gene

Variant ID Type Subtype PubMed ID
nsv1000519 CNV loss 25217958
nsv1001460 CNV gain 25217958
nsv476594 CNV novel sequence insertion 20440878

Variation tolerance for RBP2 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBP2 Gene

Disorders for RBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search RBP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBP2
genes like me logo Genes that share disorders with RBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBP2 Gene

Publications for RBP2 Gene

  1. Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution. (PMID: 18076076) Tarter M. … Monaco H.L. (Proteins 2008) 3 4 22 64
  2. Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization. (PMID: 10072590) De Baere E. … Messiaen L. (Cytogenet. Cell Genet. 1998) 2 3 22 64
  3. Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle. (PMID: 7657783) Loughney A.D. … Redfern C.P.F. (Hum. Reprod. 1995) 2 3 4 64
  4. Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein type II gene expression in intestinal cells. (PMID: 19147806) Yamaguchi N. … Suruga K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RBP2 Gene

Sources for RBP2 Gene

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