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Aliases for RBP2 Gene

Aliases for RBP2 Gene

  • Retinol Binding Protein 2, Cellular 2 3
  • Retinol-Binding Protein 2, Cellular 2 3
  • Cellular Retinol-Binding Protein II 3 4
  • CRBP-II 3 4
  • CRBP2 3 4
  • Retinol-Binding Protein 2 3
  • CRABP-II 3
  • CRBPII 3
  • RBPC2 3
  • C 6

External Ids for RBP2 Gene

Previous GeneCards Identifiers for RBP2 Gene

  • GC03M136069
  • GC03M140000
  • GC03M140453
  • GC03M140492
  • GC03M140654
  • GC03M139171
  • GC03M136547

Summaries for RBP2 Gene

Entrez Gene Summary for RBP2 Gene

  • RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBP2 Gene

RBP2 (Retinol Binding Protein 2, Cellular) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include transporter activity and retinal binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for RBP2 Gene

  • Intracellular transport of retinol

Gene Wiki entry for RBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP2 Gene

Genomics for RBP2 Gene

Regulatory Elements for RBP2 Gene

Genomic Location for RBP2 Gene

139,452,884 bp from pter
139,480,820 bp from pter
27,937 bases
Minus strand

Genomic View for RBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP2 Gene

Proteins for RBP2 Gene

  • Protein details for RBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinol-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K7G3
    • Q6ISQ9
    • Q6ISS7

    Protein attributes for RBP2 Gene

    134 amino acids
    Molecular mass:
    15707 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP2 Gene

neXtProt entry for RBP2 Gene

Proteomics data for RBP2 Gene at MOPED

Post-translational modifications for RBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RBP2 Gene

Domains for RBP2 Gene

Gene Families for RBP2 Gene

  • FABP :Fatty acid binding protein family

Suggested Antigen Peptide Sequences for RBP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • P50120
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP2: view

Function for RBP2 Gene

Molecular function for RBP2 Gene

GENATLAS Biochemistry:
retinol binding protein 2,cellular (lipocalin family,Kernel group),monomer,involved in the transport of vitamin A in the small intestinal epithelium
UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol

Gene Ontology (GO) - Molecular Function for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding TAS 7657783
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP2: view
genes like me logo Genes that share phenotypes with RBP2: view

Animal Models for RBP2 Gene

MGI Knock Outs for RBP2:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RBP2 Gene

Localization for RBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP2 Gene


Subcellular locations from

Jensen Localization Image for RBP2 Gene COMPARTMENTS Subcellular localization image for RBP2 gene
Compartment Confidence
cytosol 4
golgi apparatus 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RBP2: view

Pathways for RBP2 Gene

genes like me logo Genes that share pathways with RBP2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006776 vitamin A metabolic process TAS 2992469
GO:0006810 transport IEA --
GO:0007603 phototransduction, visible light TAS --
GO:0008544 epidermis development TAS 1654334
genes like me logo Genes that share ontologies with RBP2: view

Compounds for RBP2 Gene

(1) Drugbank Compounds for RBP2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin A
  • [11,12-3H]-Retinol
68-26-8 carrier

(10) Novoseek inferred chemical compound relationships for RBP2 Gene

Compound -log(P) Hits PubMed IDs
vitamin a 85.1 62
retinyl ester 84.4 5
retinoid 78.6 5
retinoic acid 75 34
retinaldehyde 61.4 1
genes like me logo Genes that share compounds with RBP2: view

Transcripts for RBP2 Gene

mRNA/cDNA for RBP2 Gene

(10) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBP2 Gene

Retinol binding protein 2, cellular:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBP2 Gene

No ASD Table

Relevant External Links for RBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBP2 Gene

mRNA expression in normal human tissues for RBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBP2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (51.1).

Protein differential expression in normal tissues for RBP2 Gene

This gene is overexpressed in Fetal gut (59.0) and Pancreatic juice (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBP2 Gene

SOURCE GeneReport for Unigene cluster for RBP2 Gene Hs.655516

mRNA Expression by UniProt/SwissProt for RBP2 Gene

Tissue specificity: Higher expression in adult small intestine and to a much lesser extent in fetal kidney.
genes like me logo Genes that share expressions with RBP2: view

Expression partners for RBP2 Gene

In Situ Assay Products

Orthologs for RBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBP2 35
  • 88.31 (n)
  • 86.57 (a)
RBP2 36
  • 87 (a)
(Canis familiaris)
Mammalia RBP2 35
  • 89.3 (n)
  • 88.81 (a)
RBP2 36
  • 89 (a)
(Mus musculus)
Mammalia Rbp2 35
  • 86.82 (n)
  • 91.04 (a)
Rbp2 16
Rbp2 36
  • 91 (a)
(Pan troglodytes)
Mammalia RBP2 35
  • 99.25 (n)
  • 97.76 (a)
RBP2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Rbp2 35
  • 87.06 (n)
  • 90.3 (a)
(Monodelphis domestica)
Mammalia RBP2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia RBP2 36
  • 81 (a)
(Gallus gallus)
Aves RBP2 35
  • 72.89 (n)
  • 79.1 (a)
RBP2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia RBP2 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbp2 35
  • 74.38 (n)
  • 76.12 (a)
Str.15607 35
(Danio rerio)
Actinopterygii rbp2 35
rbp2a 35
  • 74.13 (n)
  • 75.37 (a)
rbp2a 36
  • 75 (a)
Species with no ortholog for RBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP2 Gene

Gene Tree for RBP2 (if available)
Gene Tree for RBP2 (if available)

Paralogs for RBP2 Gene

Selected SIMAP similar genes for RBP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBP2: view

Variants for RBP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBP2 Gene

Variant ID Type Subtype PubMed ID
nsv877543 CNV Gain 21882294

Relevant External Links for RBP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RBP2 Gene

Disorders for RBP2 Gene

(1) University of Copenhagen DISEASES for RBP2 Gene

(1) Novoseek inferred disease relationships for RBP2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with RBP2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for RBP2 Gene

Publications for RBP2 Gene

  1. Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization. (PMID: 10072590) De Baere E. … Messiaen L. (Cytogenet. Cell Genet. 1998) 2 3 23
  2. Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution. (PMID: 18076076) Tarter M. … Monaco H.L. (Proteins 2008) 3 4 23
  3. Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle. (PMID: 7657783) Loughney A.D. … Redfern C.P.F. (Hum. Reprod. 1995) 2 3 4
  4. Identification, retinoid binding and X-ray analysis of a human retinol-binding protein. (PMID: 11274389) Folli C. … Berni R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  5. Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein type II gene expression in intestinal cells. (PMID: 19147806) Yamaguchi N. … Suruga K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009) 3 23

Products for RBP2 Gene

Sources for RBP2 Gene

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