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RBP2 Gene

protein-coding   GIFtS: 58
GCID: GC03M139171

Retinol Binding Protein 2, Cellular

(Previous names: retinol-binding protein 2, cellular)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinol Binding Protein 2, Cellular1 2     CRABP-II2
Retinol-Binding Protein 2, Cellular1 2     CRBPII2
Cellular Retinol-Binding Protein II2 3     RBPC22
CRBP-II2 3     Retinol-Binding Protein 22
CRBP22 3     C5

External Ids:    HGNC: 99201   Entrez Gene: 59482   Ensembl: ENSG000001141137   OMIM: 1802805   UniProtKB: P501203   

Export aliases for RBP2 gene to outside databases

Previous GC identifers: GC03M136069 GC03M140000 GC03M140453 GC03M140492 GC03M140654 GC03M136547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBP2 Gene:
RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake
and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth,
reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic
acid to the nuclei of endometrial cells during the menstrual cycle. (provided by RefSeq, Jul 2008)

GeneCards Summary for RBP2 Gene:
RBP2 (retinol binding protein 2, cellular) is a protein-coding gene. GO annotations related to this gene include retinal binding and transporter activity. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: RET2_HUMAN, P50120
Function: Intracellular transport of retinol

Gene Wiki entry for RBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBP2 gene promoter:
         GR   AML1a   GATA-3   GCNF   XBP-1   POU2F1   POU2F1a   GCNF-1   GR-alpha   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBP2 promoter sequence
   Search Chromatin IP Primers for RBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

RBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBP2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M139171:  view genomic region     (about GC identifiers)

Start:
139,171,726 bp from pter      End:
139,199,589 bp from pter
Size:
27,864 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RET2_HUMAN, P50120 (See protein sequence)
Recommended Name: Retinol-binding protein 2  
Size: 134 amino acids; 15707 Da
Selected PDB 3D structures from and Proteopedia for RBP2 (see all 7):
2RCQ (3D)        2RCT (3D)        4EDE (3D)        4EEJ (3D)        4EFG (3D)        4EXZ (3D)    
Secondary accessions: A8K7G3 Q6ISQ9 Q6ISS7

Explore the universe of human proteins at neXtProt for RBP2: NX_P50120

Explore proteomics data for RBP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004155.2  
    ENSEMBL proteins: 
     ENSP00000232217   ENSP00000424333   ENSP00000421266  
    Reactome Protein details: P50120

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    antibodies-online proteins for RBP2 (15 products) 

     
    antibodies-online peptides for RBP2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FABP: Fatty acid binding protein family

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P50120

    ProtoNet protein and cluster: P50120

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: RET2_HUMAN, P50120
    Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    Find genes that share domains with RBP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RET2_HUMAN, P50120
    Function: Intracellular transport of retinol

         Genatlas biochemistry entry for RBP2:
    retinol binding protein 2,cellular (lipocalin family,Kernel group),monomer,involved in the transport of vitamin A
    in the small intestinal epithelium

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005501retinoid binding TAS7657783
    GO:0016918retinal binding IEA--
    GO:0019841retinol binding IEA--
         
    Find genes that share ontologies with RBP2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RBP2:
     Decreased viability of wild-ty  Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rbp2):
     digestive/alimentary  homeostasis/metabolism  other 

    Find genes that share phenotypes with RBP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rbp2tm1Eli for RBP2

       genOway: Develop your customized and physiologically relevant rodent model for RBP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RET2_HUMAN, P50120: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    golgi apparatus4
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with RBP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RBP2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    2the visual cycle I (vertebrates)
    the visual cycle I (vertebrates)0.52
    retinol biosynthesis0.52
    3Signaling by GPCR
    Signal Transduction0.58
    4Vitamin digestion and absorption
    Vitamin digestion and absorption
    5Vitamin A and carotenoid metabolism
    Vitamin A and carotenoid metabolism


    Find genes that share SuperPaths with RBP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for RBP2
        Vitamin A and carotenoid metabolism
    Regulation of retinoblastoma protein
    the visual cycle I (vertebrates)
    retinol biosynthesis


    1 Reactome Pathway for RBP2
        Retinoid metabolism and transport


    1 Kegg Pathway  (Kegg details for RBP2):
        Vitamin digestion and absorption

        Pathway & Disease-focused RT2 Profiler PCR Array including RBP2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RBP2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for RBP2 (P501203 ENSP000002322174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRATO952373, ENSP000003372244I2D: score=1 STRING: ENSP00000337224
    MORF4L1Q9UBU83, ENSP000003313104I2D: score=1 STRING: ENSP00000331310
    MORF4L2Q150143I2D: score=1 
    USP3ENSP000003696814STRING: ENSP00000369681
    --ENSP000003419664STRING: ENSP00000341966
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0006776vitamin A metabolic process TAS2992469
    GO:0007603phototransduction, visible light TAS--
    GO:0008544epidermis development TAS1654334

    Find genes that share ontologies with RBP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for RBP2 (RET2)

    1 DrugBank Compound for RBP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8carrier--16351764

    10 Novoseek inferred chemical compound relationships for RBP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 85.1 121 9040537 (5), 8487303 (5), 8463337 (5), 7864119 (3) (see all 38)
    retinyl ester 84.4 11 7864119 (2), 19147806 (1), 8841765 (1), 8463337 (1)
    retinoid 78.6 6 9040537 (1), 10092641 (1), 20122816 (1), 9593676 (1) (see all 5)
    retinoic acid 75 58 9040537 (6), 8288643 (3), 12485405 (3), 10231366 (2) (see all 20)
    retinaldehyde 61.4 1 9684745 (1)
    betacarotene 58.2 6 8606622 (3), 14704326 (1), 11250537 (1), 10466750 (1)
    fatty acid 20.3 8 10231366 (1), 9741849 (1), 8422392 (1), 12230582 (1) (see all 5)
    lipid 2.96 4 9037178 (1), 19148799 (1)
    thymidine 0 1 9599664 (1)
    phospholipid 0 2 9037178 (1)



    Find genes that share compounds with RBP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RBP2 gene: 
    NM_004164.2  

    Unigene Cluster for RBP2:

    Retinol binding protein 2, cellular
    Hs.655516  [show with all ESTs]
    Unigene Representative Sequence: NM_004164
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232217(uc003eth.3) ENST00000511956 ENST00000506825
    miRNA
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    Additional mRNA sequence: 

    AK291978.1 BC069296.1 BC069361.1 BC069396.1 BC069424.1 BC069447.1 BC069469.1 BC069513.1 
    BC069522.1 U13831.1 

    2 DOTS entries:

    DT.100737214  DT.92416939 

    20 AceView cDNA sequences:

    NM_004164 BX282005 BC069296 BC069361 BC069396 BC069424 BC069447 BC069469 
    AW772327 AI076320 BC069513 BC069522 T57756 T63918 U13831 AI340234 
    T63266 H53080 H53184 BG205701 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGGCACT
    RBP2 Expression
    About this image


    RBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Epidermis (Integumentary System)
     
     Testis (Reproductive System)
    RBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655516

    UniProtKB/Swiss-Prot: RET2_HUMAN, P50120
    Tissue specificity: Higher expression in adult small intestine and to a much lesser extent in fetal kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including RBP2: 
              Polycomb & Trithorax Complexes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RBP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbp21 , 5 retinol binding protein 2, cellular1, 5 86.82(n)1
    91.04(a)1
      9 (51.37 cM)5
    196601  NM_009034.41  NP_033060.31 
     984905375 
    chicken
    (Gallus gallus)
    Aves RBP21 retinol binding protein 2, cellular 72.89(n)
    79.1(a)
      424822  NM_001277417.1  NP_001264346.1 
    lizard
    (Anolis carolinensis)
    Reptilia RBP26
    retinol binding protein 2, cellular
    77(a)
    1 ↔ 1
    3(27439066-27452516)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156072 Transcribed sequence with moderate similarity to protein more 77(n)    BX715015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rbp22 retinol binding protein 2, cellular 77.27(n)   171475  BC062286.1 


    ENSEMBL Gene Tree for RBP2 (if available)
    TreeFam Gene Tree for RBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBP2 gene
    FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  FABP32  RBP12  
    CRABP12  FABP22  PMP22  FABP72  RBP72  
    14 SIMAP similar genes for RBP2 using alignment to 4 protein entries:     RET2_HUMAN (see all proteins):
    RBP7    RBP5    FABP3    RBP1    DKFZp547J2313    FABP7
    CRABP2    CRABP1    FABP4    PMP2    FABP2    FABP9
    FABP12    FABP5

    Find genes that share paralogs with RBP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBP2 (see all 535)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892059231,2
    --139171312(+) AGTGAA/CCCCCT 1 -- ds50010--------
    rs38215461,2
    C,F,H--139171328(-) CAGCCC/TTGTGC 1 -- ds500122Minor allele frequency- T:0.20EA NS NA WA CSA 3841
    rs1149601571,2
    --139171529(+) TGTGCA/GGGCCA 1 -- ds50010--------
    rs1140762891,2
    C--139171575(+) CCCCCA/GTGTCC 1 -- ds50010--------
    rs1176460861,2
    C--139171980(+) CTTGAC/TGGCAC 2 H R mis11Minor allele frequency- T:0.01EA 120
    rs1818478301,2
    --139172072(+) CTCAGC/TCCCCT 1 -- int10--------
    rs22338191,2
    C,F,H--139172097(-) TCCAAC/TCTCCC 1 -- int17Minor allele frequency- T:0.00NS EA NA 802
    rs1393282331,2
    --139172220(+) ACTATA/GAAAAT 1 -- int10--------
    rs1870669431,2
    --139172238(+) GCAAAG/TAAATG 1 -- int10--------
    rs1906908211,2
    --139172279(+) ATGATG/TAAAGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RBP2 (139171726 - 139199589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RBP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877543CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for RBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180280    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RBP2:
    Embryonal carcinoma

    Find genes that share disorders with RBP2           About GenesLikeMe

    1 Novoseek inferred disease relationship for RBP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 15448016 (1)


    Export disorders for RBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBP2 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with RBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle. (PubMed id 7657783)1, 2, 3 Loughney A.D.... Redfern C.P.F. (Hum. Reprod. 1995)
    2. Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization. (PubMed id 10072590)1, 3, 9 De Baere E....Messiaen L. (Cytogenet. Cell Genet. 1998)
    3. Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution. (PubMed id 18076076)1, 2, 9 Tarter M....Monaco H.L. (Proteins 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification, retinoid binding and X-ray analysis of a human retinol-binding protein. (PubMed id 11274389)1, 2 Folli C.... Berni R. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    6. Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein type II gene expression in intestinal cells. (PubMed id 19147806)1, 9 Yamaguchi N....Suruga K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    7. Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation. (PubMed id 12016134)1, 9 Zhang L....Li E. (Am. J. Physiol. Gastrointest. Liver Physiol. 2002)
    8. Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins. (PubMed id 1322170)1, 9 Herr F.M. and Ong D.E. (Biochemistry 1992)
    9. Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212. (PubMed id 23922798)1 Liang X....Chen C. (PLoS ONE 2013)
    10. Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis. (PubMed id 23722541)1 Teng Y.C....Juan L.J. (Cancer Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5948 HGNC: 9920 AceView: RBP2 Ensembl:ENSG00000114113 euGenes: HUgn5948
    ECgene: RBP2 Kegg: 5948 H-InvDB: RBP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBP2 gene:
    Search GeneIP for patents involving RBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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