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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBP1 Gene

protein-coding   GIFtS: 57
GCID: GC03M139236

retinol binding protein 1, cellular

(Previous names: retinol-binding protein 1, cellular )
 Explore 45 diseases affiliated with
RBP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RBP1    

Aliases
for RBP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Retinol Binding Protein 1, Cellular1 2     Retinol-Binding Protein 1, Cellular1 2
CRBP1 2 3     Cellular Retinol-Binding Protein I2 3
CRBP11 2 3     CRBP-I2 3
CRABP-I1 2     Retinol-Binding Protein 12
CRBPI1 2     Cellular Retinol-Binding Protein3
RBPC1 2     C5

External Ids:    HGNC: 99191   Entrez Gene: 59472   Ensembl: ENSG000001141157   OMIM: 1802605   UniProtKB: P094553   

Export aliases for RBP1 gene to outside databases

Previous GC identifers: GC03M136134 GC03M140065 GC03M140517 GC03M140557 GC03M140718 GC03M136611


Summaries
for RBP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RBP1:
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage
site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of
epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: RET1_HUMAN, P09455
Function: Intracellular transport of retinol

Gene Wiki entry for RBP1


Genomic Views
for RBP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBP1 gene promoter:
         Elk-1   p53   MAZR   p300   RelA   Nkx2-5   FOXC1   POU2F1   POU2F1a   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q21-q23

RBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M139236:  view genomic region     (about GC identifiers)

Start:
 139,236,276 bp from pter      End:
 139,258,671 bp from pter
Size:
 22,396 bases      Orientation:
 minus strand

Proteins
for RBP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RET1_HUMAN, P09455 (See protein sequence)
Recommended Name: Retinol-binding protein 1  
Size: 135 amino acids; 15850 Da
Subcellular location: Cytoplasm
Secondary accessions: B7Z7A0 E7EWV0 F2Z2F2 Q6FGX8
Alternative splicing: 3 isoforms:  P09455-1   P09455-2   P09455-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBP1: NX_P09455

RBP1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (3 alternative transcripts): 
NP_001124464.1  NP_001124465.1  NP_002890.2  

ENSEMBL proteins: 
 ENSP00000232219   ENSP00000424813   ENSP00000427492   ENSP00000429166  
Reactome Protein details: P09455
Human Recombinant Protein Products: 
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Novus Biologicals RBP1 Lysate
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ProSpec Recombinant Protein for RBP1
Uscn Proteins for RBP1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005829cytosol IEA--
GO:0044297cell body IEA--


RBP1 for ontologies           About GeneDecksing



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Uscn Antibodies for RBP1
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Uscn ELISAs and CLIAs for RBP1

Protein Domains /
Families
for RBP1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
RBP1 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR012674 Calycin
 IPR011038 Calycin-like
 IPR000463 Fatty_acid-bd
 IPR000566 Lipocln_cytosolic_FA-bd_dom

Graphical View of Domain Structure for InterPro Entry P09455

ProtoNet protein and cluster: P09455

1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: RET1_HUMAN, P09455
Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)
Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


Function
for RBP1 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: RET1_HUMAN, P09455
Function: Intracellular transport of retinol

     Genatlas biochemistry entry for RBP1:
retinol binding protein 1,cellular (lipocalin family,Kernel group),monomer,essential for vitamin A homeostasis

miRNA
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SwitchGear 3'UTR luciferase reporter plasmid: RBP1 3' UTR sequence
Inhib. RNA
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OriGene shRNA RFP: RBP1
OriGene siRNA: RBP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBP1

Gene Editing
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Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBP1 (see all 6)
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Cell Line
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In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity IEA--
GO:0005501retinoid binding TAS3472205
GO:0008289lipid binding ----
GO:0016918retinal binding IEA--
GO:0019841retinol binding IEA--


RBP1 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Rbp1tm1Ipc for RBP1
     11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rbp1):
 endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
 immune system  liver/biliary system  nervous system  pigmentation  reproductive system 
 vision/eye 

RBP1 for phenotypes           About GeneDecksing


Pathways & Interactions
for RBP1 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1retinoate biosynthesis II
retinoate biosynthesis II1.00
Defective LRAT does not esterify atROL and PALM to RPALM0.33
retinoate biosynthesis I0.38
Parenchymal atROL translocates to HSCs0.33
2Retinoid metabolism and transport
Retinoid metabolism and transport1.00
Diseases associated with visual transduction0.73
Visual phototransduction0.74
3the visual cycle I (vertebrates)
the visual cycle I (vertebrates)1.00
The canonical retinoid cycle in rods (twilight vision)0.50
retinol biosynthesis0.52
4Disease
Disease1.00
5Visual Cycle in Retinal Rods
Visual Cycle in Retinal Rods1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RBP1
    Visual Cycle in Retinal Rods

5/6 BioSystems Pathways for RBP1 (see all 6) 
    Vitamin A and carotenoid metabolism
Retinoic acid receptors-mediated signaling
the visual cycle I (vertebrates)
retinoate biosynthesis I
retinoate biosynthesis II

5/9        Reactome Pathways for RBP1 (see all 9)
    Diseases associated with visual transduction
Retinoid cycle disease events
Retinoid metabolism and transport
Defective LRAT does not esterify atROL and PALM to RPALM
Signal Transduction



RBP1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/16 Interacting proteins for RBP1 (P094553 ENSP000002322194) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
SAP30O754463, ENSP000002965044I2D: score=3 STRING: ENSP00000296504
LRP2P981643, ENSP000002638164I2D: score=2 STRING: ENSP00000263816
RBBP4Q090283, ENSP000003625924I2D: score=2 STRING: ENSP00000362592
BRMS1Q9HCU93, ENSP000003960524I2D: score=1 STRING: ENSP00000396052
LRATO952373, ENSP000003372244I2D: score=1 STRING: ENSP00000337224
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002138retinoic acid biosynthetic process IEA--
GO:0006776vitamin A metabolic process TAS3472205
GO:0030852regulation of granulocyte differentiation IEA--
GO:0033189response to vitamin A IEA--
GO:0042572retinol metabolic process IEA--


RBP1 for ontologies           About GeneDecksing



Drugs & Compounds
for RBP1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RBP1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RBP1

2 DrugBank Compounds for RBP1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8target--15994349 15951260 16011460 16156801 16157297
Acitretin-- 55079-83-9targetagonist8375617

10/25 Novoseek chemical compound relationships for RBP1 gene (see all 25)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin a 91.6 514 9147140 (10), 7835405 (10), 7744071 (8), 8463337 (6) (see all 99)
retinoid 87.8 49 7744071 (3), 10506831 (2), 7586162 (2), 12153175 (2) (see all 30)
retinaldehyde 87.1 19 19250215 (3), 8440409 (1), 10559215 (1), 10800207 (1) (see all 6)
retinoic acid 86.1 197 7615982 (9), 19250215 (4), 9858140 (4), 12153175 (4) (see all 68)
retinyl ester 79.5 14 7864119 (3), 8228637 (1), 9147140 (1), 8914940 (1) (see all 6)
9-cis-retinol 70.9 1 11360992 (1)
11-cis-retinol 61.6 2 15928609 (1)
n-(4-hydroxyphenyl)retinamide 56.9 1 7744071 (1)
isoprene 53.7 1 7744071 (1)
nad+ 51.1 1 18569334 (1)

Search CenterWatch for drugs/clinical trials and news about RBP1 / RET1 

Transcripts
for RBP1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for RBP1 gene (3 alternative transcripts): 
NM_001130992.1  NM_001130993.1  NM_002899.3  

Unigene Cluster for RBP1:

Retinol binding protein 1, cellular
Hs.529571  [show with all ESTs]
Unigene Representative Sequence: AK309492
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000474490 ENST00000232219(uc003eti.2) ENST00000483943(uc011bmx.2)
ENST00000487424(uc010huj.3) ENST00000492918(uc011bmy.2)

miRNA
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SwitchGear 3'UTR luciferase reporter plasmid: RBP1 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
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OriGene shRNA RFP: RBP1
OriGene siRNA: RBP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBP1
Clone
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GenScript: all cDNA clones in your preferred vector (see all 3): RBP1 (NM_002899)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP1 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBP1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBP1

Additional cDNA sequence: 

AK290315.1 AK301684.1 AK307378.1 AK309492.1 BC121052.2 CR541979.1 CR542005.1 M11433.1 
M36809.1 

7 DOTS entries:

DT.100776630  DT.99955551  DT.97788656  DT.100776631  DT.316267  DT.95069622  DT.421579 

24/213 AceView cDNA sequences (see all 213):

BU740318 BE264410 AI094902 BU732518 AW189399 AA972852 AW160737 N91971 
BU069076 AI873672 BM984614 AI971961 AI041523 BG654561 BM710490 BU782824 
BM667492 BQ581751 AI094810 CR542005 CA440876 AA129681 BM710088 BM707739 

GeneLoc Exon Structure


Expression
for RBP1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATAAAGT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

RBP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
4 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
LiverSinusoidsHepatic Stellate CellsLiver
KidneyMetanephrosKidney
KidneyRenal VesicleKidney
Reproductive SystemMesonephrosReproductive System
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
NameCategory
PureStem™ progenitor E68 (Embryonic Progenitor Cell)
PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
PureStem™ progenitor E69 (Embryonic Progenitor Cell)
PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
PureStem™ progenitor W10 (Embryonic Progenitor Cell)

See RBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBP1

SOURCE GeneReport for Unigene cluster: Hs.529571

UniProtKB/Swiss-Prot: RET1_HUMAN, P09455
Tissue specificity: Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland
and adrenal gland, and fetal liver

    SABiosciences Expression via Pathway-Focused PCR Arrays including RBP1: 
          Lymphoma in human mouse rat
          Prostate Cancer in human mouse rat

Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP1

Orthologs
for RBP1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for RBP1 gene from 5/14 species (see all 14)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves RBP11 retinol binding protein 1, cellular 74.57(n)
85.19(a)		   424821  XM_422635.2  XP_422635.1 
lizard
(Anolis carolinensis)		 Reptilia RBP16
 --
 77(a)
 1 ↔ 1
 3(27347640-27348427)
African clawed frog
(Xenopus laevis)		 Amphibia Xl.61912 Xenopus laevis transcribed sequence with moderate similarity more 76.92(n)    48019930 
zebrafish
(Danio rerio)		 Actinopterygii Dr.158812 Transcribed sequence with moderate similarity to protein more 71.93(n)    BM530104.1 
fruit fly
(Drosophila melanogaster)		 Insecta fabp6
 fatty acid bindin protein
 24(a)
 possible ortholog
 3R(7385612-7392771)


ENSEMBL Gene Tree for RBP1 (if available)
TreeFam Gene Tree for RBP1 (if available) 

Paralogs
for RBP1 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RBP1 gene
FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  FABP32  CRABP12  
RBP22  FABP22  PMP22  FABP72  RBP72  
14 SIMAP similar genes for RBP1 using alignment to 2 protein entries:     RET1_HUMAN (see all proteins):
RBP5    RBP7    DKFZp547J2313    FABP7    RBP2    CRABP1
CRABP2    FABP4    FABP5    PMP2    FABP3    FABP9
FABP12    FABP2

RBP1 for paralogs           About GeneDecksing



Genomic Variants
for RBP1 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/351 NCBI SNPs in RBP1 are shown (see all 351)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 3 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1146346581,2
C,--139235803(+) GGTGGA/TTGGTC 1 -- int10--------
rs1445446401,2
--139235955(+) TACTGG/TGCAGT 1 -- int10--------
rs1484321781,2
--139235995(+) CTAGGA/GTGGAA 1 -- int10--------
rs1438192401,2
--139236311(+) ATGGC-/TTTGT 
        TTTAA 		1 -- ut310--------
rs2012597091,2
--139236451(+) GGACAA/GGGTTG 1 -- ut310--------
rs1131880161,2
C--139236524(+) TCTCCA/TGAAAC 1 -- spa11Minor allele frequency- T:0.00CSA 1
rs2007018711,2
--139236572(+) ACTTAC/TGGCAA 1 -- int10--------
rs1482803161,2
C,--139236602(+) GGCTG-/GTTTATT 1 -- int10--------
rs1418393261,2
--139236603(+) TGTTA-/TTTTTT 1 -- int10--------
rs20713881,2
C,F,A,H,--139236683(-) GTAGGG/ATGCTG 1 -- int115Minor allele frequency- A:0.29NS EA NA WA CSA 783

HapMap Linkage Disequilibrium report for RBP1 (139236276 - 139258671 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for RBP1: --

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Disorders / Diseases
for RBP1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
RBP1 for disorders           About GeneDecksing

OMIM gene information: 180260    OMIM disorders: --

20/45 diseases for RBP1 (see all 45):    About MalaCards
retinol binding protein    blepharophimosis, ptosis, and epicanthus inversus syndrome    alcoholism    maturity-onset diabetes of the young
blepharophimosis    non-small cell lung carcinoma    seborrheic keratosis    cervical intraepithelial neoplasia
uterine fibroid    fetal alcohol syndrome    squamous cell carcinoma    laryngeal squamous cell carcinoma
ptosis    esophageal squamous cell carcinoma    acute promyelocytic leukemia    basal cell carcinoma
carcinoma    keratoacanthoma    endometrial carcinoma    leiomyoma

10/22 Novoseek disease relationships for RBP1 gene (see all 22)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
epicanthus 54.5 2 9727204 (1)
blepharophimosis 49.7 2 9727204 (1)
carcinoma endometrioid 36.9 5 16575402 (4), 15500655 (1)
endometrial hyperplasia 36.8 3 16575402 (2), 15500655 (1)
squamous cell cancer 24.1 2 1329518 (1)
ovarian carcinoma 20.8 2 12631600 (2)
hyperpigmentation 16.3 1 9858140 (1)
tumors 12.2 27 12631600 (3), 12384555 (3), 16575402 (3), 12883492 (2) (see all 14)
ovarian cancer 11.3 15 12631600 (4), 11879576 (3), 19110304 (2)
breast cancer 11 27 15113415 (8), 10716965 (2), 8801168 (2), 11704871 (2) (see all 8)

Human Genome Epidemiology (HuGE) Navigator: RBP1 (5 documents)

Export disorders for RBP1 gene to outside databases

Publications
for RBP1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RBP1 gene, integrated from 9 sources (see all 224):
(articles sorted by number of sources associating them with RBP1)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. (PubMed id 9858824)1, 3, 9 De Baere E....Messiaen L. (1998)
  2. Identification, retinoid binding and X-ray analysis of a human retinol-binding protein. (PubMed id 11274389)1, 2, 9 Folli C.... Berni R. (2001)
  3. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PubMed id 1654334)1, 3 Astroem A....Voorhees J.J. (1991)
  4. Human cellular retinol-binding protein gene organization and chromosomal location. (PubMed id 3356192)1, 2 Nilsson M.H.L.... Peterson P.A. (1988)
  5. Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression. (PubMed id 2856408)1, 2 Wei L.-N.... Nguyen-Huu M.C. (1987)
  6. Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. (PubMed id 2992469)1, 2 Colantuoni V.... Sundelin J. (1985)
  7. Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival. (PubMed id 12883492)1, 9 Schmitt-Graff A....Blum H.E. (2003)
  8. Cellular retinol-binding protein-1 expression in normal and fibrotic/cirrhotic human liver: different patterns of expression in hepatic stellate cells and (myo)fibroblast subpopulations. (PubMed id 15094224)1, 9 Lepreux S....Desmouliere A. (2004)
  9. Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer. (PubMed id 12631600)1, 9 Cvetkovic D....Hamilton T.C. (2003)
  10. Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver. (PubMed id 19052772)1, 9 Van Rossen E....Geerts A. (2009)

External Searches for RBP1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Disorders
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Genome Databases showing RBP1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 5947 HGNC: 9919 AceView: RBP1 Ensembl:ENSG00000114115 euGenes: HUgn5947
ECgene: RBP1 H-InvDB: RBP1

Other Databases showing RBP1 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing RBP1 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RBP1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RBP1 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for RBP1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RBP1 gene:
Search GeneIP for patents involving RBP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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