Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RBP1 Gene

protein-coding   GIFtS: 60
GCID: GC03M139236

Retinol Binding Protein 1, Cellular

(Previous names: retinol-binding protein 1, cellular)
  See RBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Retinol Binding Protein 1, Cellular1 2     CRABP-I2
Retinol-Binding Protein 1, Cellular1 2     CRBPI2
Cellular Retinol-Binding Protein I2 3     RBPC2
CRBP2 3     Retinol-Binding Protein 12
CRBP-I2 3     Cellular Retinol-Binding Protein3
CRBP12 3     C5

External Ids:    HGNC: 99191   Entrez Gene: 59472   Ensembl: ENSG000001141157   OMIM: 1802605   UniProtKB: P094553   

Export aliases for RBP1 gene to outside databases

Previous GC identifers: GC03M136134 GC03M140065 GC03M140517 GC03M140557 GC03M140718 GC03M136611


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RBP1 Gene:
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver
storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction,
differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for RBP1 Gene:
RBP1 (retinol binding protein 1, cellular) is a protein-coding gene. Diseases associated with RBP1 include acute promyelocytic leukemia. GO annotations related to this gene include retinal binding and transporter activity. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: RET1_HUMAN, P09455
Function: Intracellular transport of retinol

Gene Wiki entry for RBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBP1 gene promoter:
         Elk-1   p53   MAZR   p300   RelA   Nkx2-5   FOXC1   POU2F1   POU2F1a   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBP1 promoter sequence
   Search Chromatin IP Primers for RBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q21-q23

RBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M139236:  view genomic region     (about GC identifiers)

Start:
139,236,276 bp from pter      End:
139,258,671 bp from pter
Size:
22,396 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RET1_HUMAN, P09455 (See protein sequence)
Recommended Name: Retinol-binding protein 1  
Size: 135 amino acids; 15850 Da
Secondary accessions: A8K2Q0 B7Z7A0 E7EWV0 F2Z2F2 Q6FGX8
Alternative splicing: 3 isoforms:  P09455-1   P09455-2   P09455-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBP1: NX_P09455

Explore proteomics data for RBP1 at MOPED


See RBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001124464.1  NP_001124465.1  NP_002890.2  

ENSEMBL proteins: 
 ENSP00000232219   ENSP00000424813   ENSP00000427492   ENSP00000429166  
Reactome Protein details: P09455

RBP1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for RBP1
OriGene Protein Over-expression Lysate for RBP1
OriGene MassSpec for RBP1
OriGene Custom Protein Services for RBP1
GenScript Custom Purified and Recombinant Proteins Services for RBP1
Novus Biologicals RBP1 Proteins
Novus Biologicals RBP1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for RBP1
Cloud-Clone Corp. Proteins for RBP1

 
Search eBioscience for Proteins for RBP1 

RBP1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for RBP1
OriGene Custom Antibody Services for RBP1
Novus Biologicals RBP1 Antibodies
Abcam antibodies for RBP1 (P09455, P02753)
Cloud-Clone Corp. Antibodies for RBP1
ThermoFisher Antibody for RBP1
LSBio Antibodies in human, mouse, rat for RBP1

RBP1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for RBP1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for RBP1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for RBP1
Cloud-Clone Corp. CLIAs for RBP1
Search eBioscience for ELISAs for RBP1 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
FABP: Fatty acid binding protein family

4 InterPro protein domains:
 IPR012674 Calycin
 IPR011038 Calycin-like
 IPR000463 Fatty_acid-bd
 IPR000566 Lipocln_cytosolic_FA-bd_dom

Graphical View of Domain Structure for InterPro Entry P09455

ProtoNet protein and cluster: P09455

1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: RET1_HUMAN, P09455
Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)
Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


Find genes that share domains with RBP1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RET1_HUMAN, P09455
Function: Intracellular transport of retinol

     Genatlas biochemistry entry for RBP1:
retinol binding protein 1,cellular (lipocalin family,Kernel group),monomer,essential for vitamin A homeostasis

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity IEA--
GO:0005501retinoid binding TAS3472205
GO:0008289lipid binding ----
GO:0016918retinal binding IEA--
GO:0019841retinol binding IEA--
     
Find genes that share ontologies with RBP1           About GenesLikeMe


Phenotypes:
     11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rbp1):
 endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
 immune system  liver/biliary system  nervous system  pigmentation  reproductive system 
 vision/eye 

Find genes that share phenotypes with RBP1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Rbp1tm1Ipc for RBP1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBP1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RBP1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBP1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RBP1

miRNA
Products:
    
miRTarBase miRNAs that target RBP1:
hsa-mir-335-5p (MIRT018800)

Block miRNA regulation of human, mouse, rat RBP1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RBP1
SwitchGear 3'UTR luciferase reporter plasmidRBP1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RBP1
Predesigned siRNA for gene silencing in human, mouse, rat RBP1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RBP1

Clone
Products:
     
OriGene clones in human, mouse for RBP1 (see all 17)
OriGene ORF clones in mouse, rat for RBP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): RBP1 (NM_002899)
Sino Biological Human cDNA Clone for RBP1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RBP1
Browse ESI BIO Cell Lines and PureStem Progenitors for RBP1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
RET1_HUMAN, P09455: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus2
cytoskeleton1
extracellular1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol TAS--
GO:0044297cell body ----

Find genes that share ontologies with RBP1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for RBP1 About   (see all 9)  
See pathways by source

SuperPathContained pathways About
1the visual cycle I (vertebrates)
the visual cycle I (vertebrates)0.52
The canonical retinoid cycle in rods (twilight vision)0.44
retinol biosynthesis0.52
2Diseases associated with visual transduction
Visual phototransduction0.44
Diseases associated with visual transduction0.43
Retinoid metabolism and transport0.44
Retinoid cycle disease events0.00
3retinoate biosynthesis I
retinoate biosynthesis I
retinoate biosynthesis II0.00
4Signaling by GPCR
Signal Transduction0.58
5Vitamin A and carotenoid metabolism
Vitamin A and carotenoid metabolism


Find genes that share SuperPaths with RBP1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RBP1
    Visual Cycle in Retinal Rods

Selected BioSystems Pathways for RBP1 (see all 7)
    Vitamin A and carotenoid metabolism
RB in Cancer
Retinoic acid receptors-mediated signaling
retinoate biosynthesis II
retinoate biosynthesis I


3 Reactome Pathways for RBP1
    Retinoid metabolism and transport
Retinoid cycle disease events
The canonical retinoid cycle in rods (twilight vision)


    Pathway & Disease-focused RT2 Profiler PCR Arrays including RBP1: 
          Lymphoma in human mouse rat
          Prostate Cancer in human mouse rat

Interactions:

    GeneGlobe Interaction Network for RBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

Selected Interacting proteins for RBP1 (P094553 ENSP000002322194) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
InteractantInteraction Details
GeneCardExternal ID(s)
SAP30O754463, ENSP000002965044I2D: score=3 STRING: ENSP00000296504
LRP2P981643, ENSP000002638164I2D: score=2 STRING: ENSP00000263816
RBBP4Q090283, ENSP000003625924I2D: score=2 STRING: ENSP00000362592
BRMS1Q9HCU93, ENSP000003960524I2D: score=1 STRING: ENSP00000396052
LRATO952373, ENSP000003372244I2D: score=1 STRING: ENSP00000337224
About this table

Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001523retinoid metabolic process TAS--
GO:0002138retinoic acid biosynthetic process ----
GO:0006776vitamin A metabolic process TAS3472205
GO:0007603phototransduction, visible light TAS--
GO:0030852regulation of granulocyte differentiation ----

Find genes that share ontologies with RBP1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RBP1 (RET1)

2 DrugBank Compounds for RBP1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8target--15994349 15951260 16011460 16156801 16157297
Acitretin-- 55079-83-9targetagonist8375617

Selected Novoseek inferred chemical compound relationships for RBP1 gene (see all 25)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin a 91.6 514 9147140 (10), 7835405 (10), 7744071 (8), 8463337 (6) (see all 99)
retinoid 87.8 49 7744071 (3), 10506831 (2), 7586162 (2), 12153175 (2) (see all 30)
retinaldehyde 87.1 19 19250215 (3), 8440409 (1), 10559215 (1), 10800207 (1) (see all 6)
retinoic acid 86.1 197 7615982 (9), 19250215 (4), 9858140 (4), 12153175 (4) (see all 68)
retinyl ester 79.5 14 7864119 (3), 8228637 (1), 9147140 (1), 8914940 (1) (see all 6)
9-cis-retinol 70.9 1 11360992 (1)
11-cis-retinol 61.6 2 15928609 (1)
n-(4-hydroxyphenyl)retinamide 56.9 1 7744071 (1)
isoprene 53.7 1 7744071 (1)
nad+ 51.1 1 18569334 (1)



Find genes that share compounds with RBP1           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for RBP1 gene (3 alternative transcripts): 
NM_001130992.1  NM_001130993.1  NM_002899.3  

Unigene Cluster for RBP1:

Retinol binding protein 1, cellular
Hs.529571  [show with all ESTs]
Unigene Representative Sequence: AK309492
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000474490 ENST00000232219(uc003eti.2) ENST00000483943(uc011bmx.2)
ENST00000487424(uc010huj.3) ENST00000492918(uc011bmy.2)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RBP1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RBP1
SwitchGear 3'UTR luciferase reporter plasmidRBP1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RBP1
Predesigned siRNA for gene silencing in human, mouse, rat RBP1
Clone
Products:
     
OriGene clones in human, mouse for RBP1 (see all 17)
OriGene ORF clones in mouse, rat for RBP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): RBP1 (NM_002899)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RBP1
OriGene qSTAR qPCR primer pairs in human, mouse for RBP1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBP1
  QuantiTect SYBR Green Assays in human, mouse, rat RBP1
  QuantiFast Probe-based Assays in human, mouse, rat RBP1

Additional mRNA sequence: 

AK290315.1 AK301684.1 AK307378.1 AK309492.1 BC121052.2 CR541979.1 CR542005.1 M11433.1 
M36809.1 

7 DOTS entries:

DT.100776630  DT.99955551  DT.97788656  DT.100776631  DT.316267  DT.95069622  DT.421579 

Selected AceView cDNA sequences (see all 213):

AI817990 BG152840 AW189399 AA594920 BE673460 CF528492 AA972852 AA933767 
AA129681 CA848447 BU069076 N91971 BE383317 CF528961 AI972574 AI873672 
CR542005 BU732518 CR541979 AW160737 AI094810 AI078619 AI971961 BQ285940 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

RBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCAATAAAGT
RBP1 Expression
About this image


RBP1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 18) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Caudal Ganglionic Eminence Progenitor Cells Caudal Ganglionic Eminence
         Metencephalon
 
 Liver (Hepatobiliary System)    fully expand to see all 3 entries
         Hematopoietic Stem Cells Liver Bud
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Caudal Ganglionic Eminence Progenitor Cells Caudal Ganglionic Eminence
         Cerebellum
 
 Kidney (Urinary System)    fully expand to see all 3 entries
         Presumptive Podocytes Podocyte Layer
         Metanephros
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
RBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RBP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.529571

UniProtKB/Swiss-Prot: RET1_HUMAN, P09455
Tissue specificity: Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary
gland and adrenal gland, and fetal liver

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RBP1: 
          Lymphoma in human mouse rat
          Prostate Cancer in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for RBP1
OriGene qSTAR qPCR primer pairs in human, mouse for RBP1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBP1
QuantiTect SYBR Green Assays in human, mouse, rat RBP1
QuantiFast Probe-based Assays in human, mouse, rat RBP1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for RBP1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rbp11 , 5 retinol binding protein 1, cellular1, 5 90.37(n)1
96.3(a)1
  9 (51.36 cM)5
196591  NM_011254.51  NP_035384.11 
 984229615 
chicken
(Gallus gallus)
Aves RBP11 retinol binding protein 1, cellular 74.57(n)
85.19(a)
  424821  NM_001277416.1  NP_001264345.1 
African clawed frog
(Xenopus laevis)
Amphibia Xl.61912 Xenopus laevis transcribed sequence with moderate similarity more 76.92(n)    48019930 
zebrafish
(Danio rerio)
Actinopterygii Dr.158812 Transcribed sequence with moderate similarity to protein more 71.93(n)    BM530104.1 


ENSEMBL Gene Tree for RBP1 (if available)
TreeFam Gene Tree for RBP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for RBP1 gene
FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  FABP32  RBP22  
CRABP12  FABP22  PMP22  FABP72  RBP72  
14 SIMAP similar genes for RBP1 using alignment to 2 protein entries:     RET1_HUMAN (see all proteins):
RBP5    RBP7    DKFZp547J2313    FABP7    RBP2    CRABP1
CRABP2    FABP3    FABP4    FABP5    PMP2    FABP9
FABP12    FABP2

Find genes that share paralogs with RBP1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for RBP1 (see all 413)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1146346581,2
C--139235803(+) GGTGGA/TTGGTC 1 -- int10--------
rs1445446401,2
--139235955(+) TACTGG/TGCAGT 1 -- int10--------
rs1484321781,2
C--139235995(+) CTAGGA/GTGGAA 1 -- int10--------
rs1438192401,2
C--139236311(+) ATGGC-/TTTGT 
        
TTTAA
1 -- ut310--------
rs2012597091,2
--139236451(+) GGACAA/GGGTTG 1 -- ut310--------
rs1131880161,2
C--139236524(+) TCTCCA/TGAAAC 1 -- spa11Minor allele frequency- T:0.00CSA 1
rs2007018711,2
--139236572(+) ACTTAC/TGGCAA 1 -- int10--------
rs1482803161,2
C--139236602(+) GGCTG-/GTTTATT 1 -- int10--------
rs1418393261,2
C--139236605(+) TGTTA-/TTTTTT 1 -- int10--------
rs20713881,2
C,F,A,H--139236683(-) GTAGGG/ATGCTG 1 -- int115Minor allele frequency- A:0.29NS EA NA WA CSA 783

HapMap Linkage Disequilibrium report for RBP1 (139236276 - 139258671 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for RBP1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv877543CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RBP1
DNA2.0 Custom Variant and Variant Library Synthesis for RBP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 180260    OMIM disorders: --

1 disease for RBP1:    
About MalaCards
acute promyelocytic leukemia


Find genes that share disorders with RBP1           About GenesLikeMe

Selected Novoseek inferred disease relationships for RBP1 gene (see all 22)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
epicanthus 54.5 2 9727204 (1)
blepharophimosis 49.7 2 9727204 (1)
carcinoma endometrioid 36.9 5 16575402 (4), 15500655 (1)
endometrial hyperplasia 36.8 3 16575402 (2), 15500655 (1)
squamous cell cancer 24.1 2 1329518 (1)
ovarian carcinoma 20.8 2 12631600 (2)
hyperpigmentation 16.3 1 9858140 (1)
tumors 12.2 27 12631600 (3), 12384555 (3), 16575402 (3), 12883492 (2) (see all 14)
ovarian cancer 11.3 15 12631600 (4), 11879576 (3), 19110304 (2)
breast cancer 11 27 15113415 (8), 10716965 (2), 8801168 (2), 11704871 (2) (see all 8)

Genetic Association Database (GAD): RBP1
Human Genome Epidemiology (HuGE) Navigator: RBP1 (5 documents)

Export disorders for RBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for RBP1 gene, integrated from 10 sources (see all 227):
(articles sorted by number of sources associating them with RBP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. (PubMed id 9858824)1, 3, 9 De Baere E....Messiaen L. (Cytogenet. Cell Genet. 1998)
  2. Identification, retinoid binding and X-ray analysis of a human retinol-binding protein. (PubMed id 11274389)1, 2, 9 Folli C.... Berni R. (Proc. Natl. Acad. Sci. U.S.A. 2001)
  3. Screening genes of the visual cycle RGR, RBP1 and RBP3 identifies rare sequence variations. (PubMed id 21067480)1, 4 Ksantini M....Hamel C.P. (Ophthalmic Genet. 2010)
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  5. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PubMed id 1654334)1, 3 Astroem A....Voorhees J.J. (J. Biol. Chem. 1991)
  6. Human cellular retinol-binding protein gene organization and chromosomal location. (PubMed id 3356192)1, 2 Nilsson M.H.L.... Peterson P.A. (Eur. J. Biochem. 1988)
  7. Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression. (PubMed id 2856408)1, 2 Wei L.-N.... Nguyen-Huu M.C. (Mol. Endocrinol. 1987)
  8. Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. (PubMed id 2992469)1, 2 Colantuoni V.... Sundelin J. (Biochem. Biophys. Res. Commun. 1985)
  9. Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival. (PubMed id 12883492)1, 9 Schmitt-GrAoff A....Blum H.E. (Hepatology 2003)
  10. Cellular retinol-binding protein-1 expression in normal and fibrotic/cirrhotic human liver: different patterns of expression in hepatic stellate cells and (myo)fibroblast subpopulations. (PubMed id 15094224)1, 9 Lepreux S....DesmouliA"re A. (J. Hepatol. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 5947 HGNC: 9919 AceView: RBP1 Ensembl:ENSG00000114115 euGenes: HUgn5947
ECgene: RBP1 H-InvDB: RBP1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for RBP1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RBP1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for RBP1 gene:
Search GeneIP for patents involving RBP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for RBP1   OriGene RNAi products in human, mouse, rat for RBP1  
 OriGene qPCR primer pairs and template standards for RBP1   OriGene Protein Over-expression Lysate for RBP1  
 OriGene MassSpec something-or-other for RBP1   OriGene clones in human, mouse for RBP1  
 OriGene qSTAR qPCR primer pairs in human, mouse for RBP1   OriGene Purified Protein for RBP1  
 OriGene ORF clones in mouse, rat for RBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for RBP1   OriGene Custom Protein Services for RBP1  

 
 
 Block miRNA regulation of human, mouse, rat RBP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RBP1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBP1 Predesigned siRNA for gene silencing in human, mouse, rat RBP1
 QuantiFast Probe-based Assays in human, mouse, rat RBP1 QuantiTect SYBR Green Assays in human, mouse, rat RBP1
 PCR Arrays including human, mouse, rat RBP1 Search Chromatin IP Primers for RBP1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBP1  GeneGlobe Interaction Network for RBP1
 Regulatory tfbs in RBP1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for RBP1 GenScript cDNA clones with any tag delivered in your preferred vector for RBP1
 GenScript Custom Assay Services for RBP1 GenScript Custom overexpressing Cell Line Services for RBP1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for RBP1 (RET1)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for RBP1
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 RBP1 antibodies
 RBP1 proteins
 RBP1 lysates
 Antibodies for RBP1
 See all of Abcam's Antibodies, Kits and Proteins for RBP1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for RBP1
 Proteins for RBP1
 Antibodies for RBP1
 ELISAs for RBP1
 CLIAs for RBP1



 Browse ESI BIO Cell Lines and PureStem Progenitors for RBP1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBP1
 SwitchGear 3'UTR luciferase reporter plasmids for RBP1
 SwitchGear Promoter luciferase reporter plasmids for RBP1
 ThermoFisher Antibody for RBP1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBP1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBP1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RBP1
 LSBio Antibodies in human, mouse, rat for RBP1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for RBP1
  Search eBioscience for proteins for RBP1
  Search eBioscience for elisas for RBP1
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      RBP1 gene at Home site.
Version: 3.12.212 17 Sep 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4