Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBMY1J Gene

Aliases for RBMY1J Gene

  • RNA Binding Motif Protein, Y-Linked, Family 1, Member J 2 3
  • Y Chromosome RNA Recognition Motif 2 4
  • RBMY1F RBMY1J 4
  • YRRM2 4

External Ids for RBMY1J Gene

Previous GeneCards Identifiers for RBMY1J Gene

  • GC0YU900273
  • GC0YP022959
  • GC0YP022866
  • GC0YP024456

Summaries for RBMY1J Gene

Entrez Gene Summary for RBMY1J Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMY1J Gene

RBMY1J (RNA Binding Motif Protein, Y-Linked, Family 1, Member J) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBMXL1.

UniProtKB/Swiss-Prot for RBMY1J Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1J Gene

Genomics for RBMY1J Gene

Regulatory Elements for RBMY1J Gene

Transcription factor binding sites by QIAGEN in the RBMY1J gene promoter:

Genomic Location for RBMY1J Gene

Start:
22,308,823 bp from pter
End:
22,417,881 bp from pter
Size:
109,059 bases
Orientation:
Plus strand

Genomic View for RBMY1J Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBMY1J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMY1J Gene

Proteins for RBMY1J Gene

  • Protein details for RBMY1J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15415-RBY1F_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member F/J
    Protein Accession:
    Q15415
    Secondary Accessions:
    • B2R916

    Protein attributes for RBMY1J Gene

    Size:
    496 amino acids
    Molecular mass:
    55728 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins

    Alternative splice isoforms for RBMY1J Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBMY1J Gene

Proteomics data for RBMY1J Gene at MOPED

Post-translational modifications for RBMY1J Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1J Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMY1J Gene

Domains for RBMY1J Gene

Gene Families for RBMY1J Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBMY1J Gene

Suggested Antigen Peptide Sequences for RBMY1J Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15415

UniProtKB/Swiss-Prot:

RBY1F_HUMAN :
  • Q15415
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBMY1J: view

Function for RBMY1J Gene

Molecular function for RBMY1J Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Gene Ontology (GO) - Molecular Function for RBMY1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 8269511
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBMY1J: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMY1J

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RBMY1J Gene

Localization for RBMY1J Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1J Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMY1J Gene COMPARTMENTS Subcellular localization image for RBMY1J gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBMY1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBMY1J: view

Pathways for RBMY1J Gene

SuperPathways for RBMY1J Gene

No Data Available

Interacting Proteins for RBMY1J Gene

Gene Ontology (GO) - Biological Process for RBMY1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0007283 spermatogenesis NAS 8269511
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with RBMY1J: view

No data available for Pathways by source for RBMY1J Gene

Transcripts for RBMY1J Gene

mRNA/cDNA for RBMY1J Gene

(8) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMY1J

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1J Gene

No ASD Table

Relevant External Links for RBMY1J Gene

GeneLoc Exon Structure for
RBMY1J
ECgene alternative splicing isoforms for
RBMY1J

Expression for RBMY1J Gene

mRNA expression in normal human tissues for RBMY1J Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1J Gene

This gene is overexpressed in Testis (53.0).

Protein differential expression in normal tissues for RBMY1J Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RBMY1J Gene

mRNA Expression by UniProt/SwissProt for RBMY1J Gene

Q15415-RBY1F_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with RBMY1J: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RBMY1J Gene

Orthologs for RBMY1J Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMY1J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC736145 35
  • 97.24 (n)
  • 94.35 (a)
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia RBMX 36
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10256 36
  • 41 (a)
ManyToMany
Gm10352 36
  • 41 (a)
ManyToMany
Gm21677 36
  • 41 (a)
ManyToMany
Gm21693 36
  • 41 (a)
ManyToMany
Gm21704 36
  • 41 (a)
ManyToMany
Gm21708 36
  • 41 (a)
ManyToMany
Gm3376 36
  • 42 (a)
ManyToMany
Rbmy 36
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves RBMX 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rbmx 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tra2 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 36
  • 19 (a)
OneToMany
Species with no ortholog for RBMY1J:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMY1J Gene

ENSEMBL:
Gene Tree for RBMY1J (if available)
TreeFam:
Gene Tree for RBMY1J (if available)

Paralogs for RBMY1J Gene

Paralogs for RBMY1J Gene

Selected SIMAP similar genes for RBMY1J Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBMY1J: view

Variants for RBMY1J Gene

Sequence variations from dbSNP and Humsavar for RBMY1J Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs113307592 -- 22,418,335(+) AGTTT(A/G)AATAG downstream-variant-500B
rs373809940 -- 22,407,475(+) CTACT(C/T)GCTGT intron-variant
rs199997946 -- 22,407,848(+) TGGCT(C/T)ACTGC intron-variant
rs199529099 -- 22,407,778(+) TGTTC(C/G)TTTGT intron-variant
rs112686876 -- 22,406,178(+) AACAA(A/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMY1J Gene

Variant ID Type Subtype PubMed ID
dgv2501e1 CNV Complex 17122850
essv11423 CNV CNV 17122850
essv15983 CNV CNV 17122850
nsv10029 CNV Gain 18304495
nsv10031 CNV Gain 18304495

Relevant External Links for RBMY1J Gene

HapMap Linkage Disequilibrium report
RBMY1J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMY1J Gene

Disorders for RBMY1J Gene

(2) University of Copenhagen DISEASES for RBMY1J Gene

genes like me logo Genes that share disorders with RBMY1J: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for RBMY1J Gene

Publications for RBMY1J Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4
  2. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PMID: 8269511) Ma K. … Jobling M. (Cell 1993) 3 4
  3. Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. (PMID: 8875892) Prosser J. … Cooke H.J. (Mamm. Genome 1996) 3
  4. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PMID: 9598316) Chai N.-N. … Yen P.H. (Genomics 1998) 3
  5. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. (PMID: 15184870) Tsuei D.J. … Chang M.H. (Oncogene 2004) 3

Products for RBMY1J Gene

Sources for RBMY1J Gene

Back to Top

Content