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Aliases for RBMY1J Gene

Aliases for RBMY1J Gene

  • RNA Binding Motif Protein, Y-Linked, Family 1, Member J 2 3 5
  • Y Chromosome RNA Recognition Motif 2 4
  • RBMY1F RBMY1J 4
  • YRRM2 4

External Ids for RBMY1J Gene

Previous GeneCards Identifiers for RBMY1J Gene

  • GC0YU900273
  • GC0YP022959
  • GC0YP022866
  • GC0YP024456

Summaries for RBMY1J Gene

Entrez Gene Summary for RBMY1J Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]

GeneCards Summary for RBMY1J Gene

RBMY1J (RNA Binding Motif Protein, Y-Linked, Family 1, Member J) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CIRBP.

UniProtKB/Swiss-Prot for RBMY1J Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1J Gene

Genomics for RBMY1J Gene

Regulatory Elements for RBMY1J Gene


Transcription factor binding sites by QIAGEN in the RBMY1J gene promoter:

Genomic Location for RBMY1J Gene

Chromosome:
Y
Start:
22,308,823 bp from pter
End:
22,424,890 bp from pter
Size:
116,068 bases
Orientation:
Plus strand

Genomic View for RBMY1J Gene

Genes around RBMY1J on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMY1J Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMY1J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMY1J Gene

Proteins for RBMY1J Gene

  • Protein details for RBMY1J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15415-RBY1F_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member F/J
    Protein Accession:
    Q15415
    Secondary Accessions:
    • B2R916

    Protein attributes for RBMY1J Gene

    Size:
    496 amino acids
    Molecular mass:
    55728 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

    Alternative splice isoforms for RBMY1J Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBMY1J Gene

Proteomics data for RBMY1J Gene at MOPED

Post-translational modifications for RBMY1J Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1J Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMY1J Gene

Domains & Families for RBMY1J Gene

Gene Families for RBMY1J Gene

Protein Domains for RBMY1J Gene

Suggested Antigen Peptide Sequences for RBMY1J Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15415

UniProtKB/Swiss-Prot:

RBY1F_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBMY1J: view

Function for RBMY1J Gene

Molecular function for RBMY1J Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Gene Ontology (GO) - Molecular Function for RBMY1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RBMY1J: view

Animal Model Products

CRISPR Products

miRNA for RBMY1J Gene

miRTarBase miRNAs that target RBMY1J

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMY1J Gene

Localization for RBMY1J Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1J Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMY1J Gene COMPARTMENTS Subcellular localization image for RBMY1J gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for RBMY1J Gene

Pathways & Interactions for RBMY1J Gene

SuperPathways for RBMY1J Gene

No Data Available

Interacting Proteins for RBMY1J Gene

Gene Ontology (GO) - Biological Process for RBMY1J Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBMY1J Gene

Drugs & Compounds for RBMY1J Gene

No Compound Related Data Available

Transcripts for RBMY1J Gene

mRNA/cDNA for RBMY1J Gene

(8) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1J Gene

No ASD Table

Relevant External Links for RBMY1J Gene

GeneLoc Exon Structure for
RBMY1J
ECgene alternative splicing isoforms for
RBMY1J

Expression for RBMY1J Gene

mRNA expression in normal human tissues for RBMY1J Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1J Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for RBMY1J Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RBMY1J Gene



mRNA Expression by UniProt/SwissProt for RBMY1J Gene

Q15415-RBY1F_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with RBMY1J: view

Protein tissue co-expression partners for RBMY1J Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RBMY1J Gene

Orthologs for RBMY1J Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMY1J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC736145 35
  • 97.24 (n)
  • 94.35 (a)
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia RBMX 36
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10256 36
  • 41 (a)
ManyToMany
Gm10352 36
  • 41 (a)
ManyToMany
Gm21677 36
  • 41 (a)
ManyToMany
Gm21693 36
  • 41 (a)
ManyToMany
Gm21704 36
  • 41 (a)
ManyToMany
Gm21708 36
  • 41 (a)
ManyToMany
Gm3376 36
  • 42 (a)
ManyToMany
Rbmy 36
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves RBMX 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rbmx 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tra2 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 36
  • 19 (a)
OneToMany
Species with no ortholog for RBMY1J:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMY1J Gene

ENSEMBL:
Gene Tree for RBMY1J (if available)
TreeFam:
Gene Tree for RBMY1J (if available)

Paralogs for RBMY1J Gene

(20) SIMAP similar genes for RBMY1J Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBMY1J: view

Variants for RBMY1J Gene

Sequence variations from dbSNP and Humsavar for RBMY1J Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs160733 -- 22,420,931(-) GTATG(C/T)TTTGT intron-variant
rs160736 -- 22,407,475(-) ACAGC(A/G)AGTAG intron-variant
rs160737 -- 22,407,392(+) ATGAG(C/G)CATAC intron-variant
rs112431691 -- 22,407,876(+) TTCAA(G/T)CGATT intron-variant
rs112686876 -- 22,406,178(+) AACAA(A/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMY1J Gene

Variant ID Type Subtype PubMed ID
dgv2501e1 CNV Complex 17122850
essv11423 CNV CNV 17122850
essv15983 CNV CNV 17122850
nsv10029 CNV Gain 18304495
nsv10031 CNV Gain 18304495

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for RBMY1J Gene

Disorders for RBMY1J Gene

Relevant External Links for RBMY1J

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBMY1J

No disorders were found for RBMY1J Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMY1J Gene

Publications for RBMY1J Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. (PMID: 15184870) Tsuei D.J. … Chang M.H. (Oncogene 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PMID: 9598316) Chai N.-N. … Yen P.H. (Genomics 1998) 3

Products for RBMY1J Gene

Sources for RBMY1J Gene

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