RBMY1F Gene
protein-coding GIFtS: 40
GCID: GC0YM024314
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RNA binding motif protein, Y-linked, family 1, member F
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Aliases
for RBMY1F gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein, Y-Linked, Family 1, Member F1 2 | | Y Chromosome RNA Recognition Motif 22 3 | | YRRM22 3 | | MGC330941 | | RNA-Binding Motif Protein, Y Chromosome, Family 1 Member F/J2 |
Export aliases for RBMY1F gene to outside databasesPrevious GC identifers: GC0YP022795 GC0YM022724 |
Summaries
for RBMY1F gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBMY1F:
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine,tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region ofchromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus arepseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functionalcopies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindromeP3, along with two copies of PTPN13-like, Y-linked. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RBY1F_HUMAN, Q15415Function: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly byparticipating in pre-mRNA splicing in the testis
|
Genomic Views
for RBMY1F gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011903.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBMY1F gene promoter:
POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBMY1F
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBMY1F |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yq11.223 Ensembl cytogenetic band: Yq11.223 HGNC cytogenetic band: Yq11.223RBMY1F Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YM024314: view genomic region
(about GC identifiers)
Start:
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24,314,689 bp from pter |
End:
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24,329,129 bp from pter |
Size:
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14,441 bases |
Orientation:
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minus strand |
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Proteins
for RBMY1F gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBY1F_HUMAN, Q15415 (See
protein sequence)Recommended Name: RNA-binding motif protein, Y chromosome, family 1 member F/J Size: 496 amino acids; 55728 Da
Subunit: Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3
Subcellular location: Nucleus
Developmental stage: Expressed in all of the transcriptionally active stages of germ cell development fromspermatogonia through spermatocytes to round spermatids
Miscellaneous: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region.The exact number of functional copies is unclear and may vary between individuals, and some of them may representpseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, mostexperiments do not discriminate between the different members. One can therefore suppose that reported interactionswith a RBMY1 protein involve all the proteins
Secondary accessions: B2R916Alternative splicing: 2 isoforms: Q15415-1 Q15415-2 Explore the universe of human proteins at neXtProt for RBMY1F: NX_Q15415
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15415
RBMY1F Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689798.1
ENSEMBL proteins: ENSP00000307155 ENSP00000406005
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RBMY1F for ontologies About GeneDecksing
RBMY1F Antibody Products:
Assay Products for RBMY1F: |
Protein
Domains /
Families
for RBMY1F gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBMY1F for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15415ProtoNet protein and cluster: Q15415 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB012604 RBM1CTR
UniProtKB/Swiss-Prot: RBY1F_HUMAN, Q15415Similarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for RBMY1F gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBY1F_HUMAN, Q15415Function: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly byparticipating in pre-mRNA splicing in the testis
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMY1F |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RBMY1F for ontologies About GeneDecksing
|
Pathways & Interactions
for RBMY1F gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBMY1F
1 Interacting protein for RBMY1F (Q154153) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
RBMY1F for ontologies About GeneDecksing
|
Drugs & Compounds
for RBMY1F gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBMY1F
Search CenterWatch for drugs/clinical trials and news about RBMY1F / RBY1F
|
Transcripts
for RBMY1F gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBMY1F gene: NM_152585.1 Unigene Cluster for RBMY1F: RNA binding motif protein, Y-linked, family 1, member F Hs.567746 [show with all ESTs]Unigene Representative Sequence: NM_1525853 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000303766(uc010nxh.3 uc004fva.3 uc022coi.1) ENST00000481858
ENST00000454978(uc022coh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBMY1F
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBMY1F
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBMY1F (NM_152585) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBMY1F | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBMY1F |
Additional cDNA sequence: AK313597.1 BC030018.2 BC152392.1 X76060.1 5 DOTS entries: DT.207550 DT.120651216 DT.120654377 DT.120654921 DT.97826649 2 AceView cDNA sequences: BC026077 BG718416
GeneLoc Exon Structure
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Expression
for RBMY1F gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBMY1F expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RBMY1F Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBMY1F
SOURCE GeneReport for Unigene cluster: Hs.567746
UniProtKB/Swiss-Prot: RBY1F_HUMAN, Q15415Tissue specificity: Testis-specific
SABiosciences Custom PCR Arrays for RBMY1F
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBMY1F
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RBMY1F | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBMY1F | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBMY1F | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMY1F |
Orthologs
for RBMY1F gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBMY1F gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for RBMY1F (if available)
TreeFam Gene Tree for RBMY1F (if available) |
Paralogs
for RBMY1F gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBMY1F gene
- RBMY1J1 2 RBMY1A11 2 RBMY1B1 2 RBMY1D1 2 RBMY1E1 2 RBMXL22 RBMXL32 TRA2B2
- RBMXL12 CIRBP2 RBM32 TRA2A2 RBMX2
14 SIMAP similar genes for RBMY1F using alignment to 1 protein entry: RBY1F_HUMAN:RBMY1B RBMY1A1 RBMY1C RBM RBMY1D RBMY1E
RBMY1J HNRNPA1 RBMX CIRBP RBMXL2 RBM38
RBM3 RBMXL1
RBMY1F for paralogs About GeneDecksing
|
Genomic Variants
for RBMY1F gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for RBMY1F
9 CNVs: 83944 38809 31591 0833 83945 31590 38810 4184 97202
1 Indel: 33495 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RBMY1F gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBMY1F for disorders About GeneDecksing
3  diseases for RBMY1F: About MalaCardsazoospermia gonadoblastoma liver cancer
2 diseases from the University of Copenhagen DISEASES database for RBMY1F:Gonadoblastoma Turner syndrome Export disorders for RBMY1F gene to outside databases
|
Publications
for RBMY1F gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBMY1F gene integrated from 9 sources:
(articles sorted by number of sources associating them with RBMY1F) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2, 3 Skaletsky H.... Page D.C. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PubMed id 8269511)1, 2 Ma K.... Jobling M. (1993)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. (PubMed id 15184870)1 Tsuei D.J....Chang M.H. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. (PubMed id 10749975)1 Venables J.P....Eperon E.C. (2000)
- Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PubMed id 9598316)1 Chai N.-N.... Yen P.H. (1998)
- Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. (PubMed id 8875892)1 Prosser J.... Cooke H.J. (1996)
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External Searches for RBMY1F gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RBMY1F gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBMY1F gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBMY1F gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBMY1F | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RBMY1F gene:
Search GeneIP for patents involving RBMY1F
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBMY1F gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | RBMY1F Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMY1F |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBMY1F |
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