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Aliases for RBMY1F Gene

Aliases for RBMY1F Gene

  • RNA Binding Motif Protein, Y-Linked, Family 1, Member F 2 3
  • Y Chromosome RNA Recognition Motif 2 3 4
  • YRRM2 3 4
  • RNA-Binding Motif Protein, Y Chromosome, Family 1 Member F/J 3
  • RBMY1F RBMY1J 4

External Ids for RBMY1F Gene

Summaries for RBMY1F Gene

Entrez Gene Summary for RBMY1F Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMY1F Gene

RBMY1F (RNA Binding Motif Protein, Y-Linked, Family 1, Member F) is a Protein Coding gene. An important paralog of this gene is RBMXL1.

UniProtKB/Swiss-Prot for RBMY1F Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1F Gene

Genomics for RBMY1F Gene

Genomic Location for RBMY1F Gene

Start:
22,168,542 bp from pter
End:
22,183,008 bp from pter
Size:
14,467 bases
Orientation:
Minus strand

Genomic View for RBMY1F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBMY1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMY1F Gene

Regulatory Elements for RBMY1F Gene

Transcription factor binding sites by QIAGEN in the RBMY1F gene promoter:

Proteins for RBMY1F Gene

  • Protein details for RBMY1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15415-RBY1F_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member F/J
    Protein Accession:
    Q15415
    Secondary Accessions:
    • B2R916

    Protein attributes for RBMY1F Gene

    Size:
    496 amino acids
    Molecular mass:
    55728 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins

    Alternative splice isoforms for RBMY1F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBMY1F Gene

Proteomics data for RBMY1F Gene at MOPED

Post-translational modifications for RBMY1F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMY1F Gene

Domains for RBMY1F Gene

Gene Families for RBMY1F Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBMY1F Gene

UniProtKB/Swiss-Prot:

RBY1F_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q15415
genes like me logo Genes that share domains with RBMY1F: view

Function for RBMY1F Gene

Molecular function for RBMY1F Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Gene Ontology (GO) - Molecular Function for RBMY1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 8269511
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBMY1F: view

miRNA for RBMY1F Gene

miRTarBase miRNAs that target RBMY1F

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBMY1F Gene

Localization for RBMY1F Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1F Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMY1F Gene COMPARTMENTS Subcellular localization image for RBMY1F gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBMY1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBMY1F: view

Pathways for RBMY1F Gene

SuperPathways for RBMY1F Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBMY1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0007283 spermatogenesis NAS 8269511
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with RBMY1F: view

No data available for Pathways by source for RBMY1F Gene

Transcripts for RBMY1F Gene

mRNA/cDNA for RBMY1F Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBMY1F Gene

RNA binding motif protein, Y-linked, family 1, member F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1F Gene

No ASD Table

Relevant External Links for RBMY1F Gene

GeneLoc Exon Structure for
RBMY1F
ECgene alternative splicing isoforms for
RBMY1F

Expression for RBMY1F Gene

mRNA expression in normal human tissues for RBMY1F Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1F Gene

This gene is overexpressed in Testis (53.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RBMY1F Gene

SOURCE GeneReport for Unigene cluster for RBMY1F Gene Hs.567746

mRNA Expression by UniProt/SwissProt for RBMY1F Gene

Q15415-RBY1F_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with RBMY1F: view

Orthologs for RBMY1F Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMY1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 94 (a)
ManyToMany
-- 37
  • 95 (a)
ManyToMany
-- 37
  • 94 (a)
ManyToMany
-- 37
  • 95 (a)
ManyToMany
-- 37
  • 95 (a)
ManyToMany
-- 37
  • 94 (a)
ManyToMany
LOC736145 36
  • 97.24 (n)
  • 94.35 (a)
cow
(Bos Taurus)
Mammalia RBMX 37
  • 52 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10256 37
  • 41 (a)
ManyToMany
Gm10352 37
  • 41 (a)
ManyToMany
Gm21677 37
  • 41 (a)
ManyToMany
Gm21693 37
  • 41 (a)
ManyToMany
Gm21704 37
  • 41 (a)
ManyToMany
Gm21708 37
  • 41 (a)
ManyToMany
Gm3376 37
  • 42 (a)
ManyToMany
Rbmy 37
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves RBMX 37
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rbmx 37
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tra2 37
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 37
  • 19 (a)
OneToMany
Species with no ortholog for RBMY1F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMY1F Gene

ENSEMBL:
Gene Tree for RBMY1F (if available)
TreeFam:
Gene Tree for RBMY1F (if available)

Paralogs for RBMY1F Gene

Paralogs for RBMY1F Gene

Selected SIMAP similar genes for RBMY1F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RBMY1F: view

Variants for RBMY1F Gene

Sequence variations from dbSNP and Humsavar for RBMY1F Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs112936698 -- 22,173,339(+) AAACA(C/T)GTAAA intron-variant
rs368726541 -- 22,182,502(+) CAGTG(G/T)TTAAG intron-variant
rs370822321 -- 22,182,466(+) CGACA(C/T)GTGCT intron-variant
rs374664415 -- 22,182,475(+) CTAAC(C/T)AAAAG intron-variant
rs376131297 -- 22,180,808(+) AAAAT(-/AC)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMY1F Gene

Variant ID Type Subtype PubMed ID
dgv2501e1 CNV Complex 17122850
essv11423 CNV CNV 17122850
essv15983 CNV CNV 17122850
nsv10029 CNV Gain 18304495
nsv471612 CNV Loss 15918152
nsv515226 CNV Loss 21397061
nsv442821 CNV CNV 18776908
nsv10030 CNV Gain 18304495
nsv442822 CNV CNV 18776908
nsv515227 CNV Complex 21397061
nsv10031 CNV Gain 18304495

Relevant External Links for RBMY1F Gene

HapMap Linkage Disequilibrium report
RBMY1F

Disorders for RBMY1F Gene

(2) University of Copenhagen DISEASES for RBMY1F Gene

genes like me logo Genes that share disorders with RBMY1F: view

No data available for UniProtKB/Swiss-Prot for RBMY1F Gene

Publications for RBMY1F Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PMID: 8269511) Ma K. … Jobling M. (Cell 1993) 3 4
  4. Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. (PMID: 8875892) Prosser J. … Cooke H.J. (Mamm. Genome 1996) 3
  5. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PMID: 9598316) Chai N.-N. … Yen P.H. (Genomics 1998) 3

Products for RBMY1F Gene

Sources for RBMY1F Gene

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