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RBMY1F Gene(Protein Coding)

RNA Binding Motif Protein, Y-Linked, Family 1, Member F

GCID:
GC0YM022169
GIFtS:
42
Genes Participants
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Aliases for RBMY1F Gene

Aliases for RBMY1F Gene

  • RNA Binding Motif Protein, Y-Linked, Family 1, Member F 2 3 5
  • Y Chromosome RNA Recognition Motif 2 3 4
  • YRRM2 3 4
  • RNA-Binding Motif Protein, Y Chromosome, Family 1 Member F/J 3
  • RBMY1F RBMY1J 4

External Ids for RBMY1F Gene

Previous GeneCards Identifiers for RBMY1F Gene

  • GC0YP022795
  • GC0YM022724
  • GC0YM024314

Summaries for RBMY1F Gene

Entrez Gene Summary for RBMY1F Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMY1F Gene

RBMY1F (RNA Binding Motif Protein, Y-Linked, Family 1, Member F) is a Protein Coding gene. Diseases associated with RBMY1F include Azoospermia. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMY1J.

UniProtKB/Swiss-Prot for RBMY1F Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1F Gene

Genomics for RBMY1F Gene

Products:

  1. Regulatory Element

Regulatory Elements for RBMY1F Gene


Transcription factor binding sites by QIAGEN in the RBMY1F gene promoter:

Genomic Location for RBMY1F Gene

Chromosome:
Y
Start:
22,168,181 bp from pter
End:
22,183,008 bp from pter
Size:
14,828 bases
Orientation:
Minus strand

Genomic View for RBMY1F Gene

Genes around RBMY1F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMY1F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMY1F Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RBMY1F Gene

Proteins for RBMY1F Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RBMY1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15415-RBY1F_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member F/J
    Protein Accession:
    Q15415
    Secondary Accessions:
    • B2R916

    Protein attributes for RBMY1F Gene

    Size:
    496 amino acids
    Molecular mass:
    55728 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

    Alternative splice isoforms for RBMY1F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBMY1F Gene

Protein Expression for RBMY1F Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RBMY1F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMY1F Gene

Domains & Families for RBMY1F Gene

Gene Families for RBMY1F Gene

HGNC:

Protein Domains for RBMY1F Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBMY1F: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RBMY1F Gene

Function for RBMY1F Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RBMY1F Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Gene Ontology (GO) - Molecular Function for RBMY1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 8269511
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBMY1F: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMY1F Gene

Localization for RBMY1F Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1F Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBMY1F gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBMY1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBMY1F: view

Pathways & Interactions for RBMY1F Gene

SuperPathways for RBMY1F Gene

PathCards logo More details on SuperPathways for RBMY1F
No Data Available

Gene Ontology (GO) - Biological Process for RBMY1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0007283 spermatogenesis NAS 8269511
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with RBMY1F: view

No data available for Pathways by source and SIGNOR curated interactions for RBMY1F Gene

Drugs & Compounds for RBMY1F Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RBMY1F Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RBMY1F Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBMY1F Gene

RNA binding motif protein, Y-linked, family 1, member F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1F Gene

No ASD Table

Relevant External Links for RBMY1F Gene

GeneLoc Exon Structure for
RBMY1F
ECgene alternative splicing isoforms for
RBMY1F

Expression for RBMY1F Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBMY1F Gene

mRNA expression in normal human tissues for RBMY1F Gene
mRNA expression by BioGPS for RBMY1F GenemRNA expression by GTEx for RBMY1F Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1F Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for RBMY1F Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBMY1F Gene



Protein tissue co-expression partners for RBMY1F Gene

NURSA nuclear receptor signaling pathways regulating expression of RBMY1F Gene:

RBMY1F

SOURCE GeneReport for Unigene cluster for RBMY1F Gene:

Hs.567746

mRNA Expression by UniProt/SwissProt for RBMY1F Gene:

Q15415-RBY1F_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with RBMY1F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMY1F Gene

Orthologs for RBMY1F Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMY1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC736145 34
  • 97.24 (n)
-- 35
  • 95 (a)
 ManyToMany
-- 35
  • 95 (a)
 ManyToMany
-- 35
  • 95 (a)
 ManyToMany
-- 35
  • 94 (a)
 ManyToMany
-- 35
  • 94 (a)
 ManyToMany
-- 35
  • 94 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 61 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 59 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia RBMX 35
  • 52 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Gm3376 35
  • 42 (a)
 ManyToMany
Gm10256 35
  • 41 (a)
 ManyToMany
Gm10352 35
  • 41 (a)
 ManyToMany
Gm21677 35
  • 41 (a)
 ManyToMany
Gm21693 35
  • 41 (a)
 ManyToMany
Gm21704 35
  • 41 (a)
 ManyToMany
Gm21708 35
  • 41 (a)
 ManyToMany
Rbmy 35
  • 41 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves RBMX 35
  • 62 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 58 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii rbmx 35
  • 51 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta tra2 35
  • 15 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea rsp-8 35
  • 19 (a)
 OneToMany
Species where no ortholog for RBMY1F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMY1F Gene

ENSEMBL:
Gene Tree for RBMY1F (if available)
TreeFam:
Gene Tree for RBMY1F (if available)

Paralogs for RBMY1F Gene

Paralogs for RBMY1F Gene

(13) SIMAP similar genes for RBMY1F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RBMY1F: view

Variants for RBMY1F Gene

Sequence variations from dbSNP and Humsavar for RBMY1F Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs1003449 -- 22,167,682(-) taggc(A/G)tgtgc utr-variant-3-prime
rs112554694 -- 22,171,848(+) TCTAG(A/T)GGAAT reference, missense
rs112936698 -- 22,173,339(+) AAACA(C/T)GTAAA intron-variant
rs160738 -- 22,182,502(-) CTTAA(A/C)CACTG intron-variant, upstream-variant-2KB
rs161692 -- 22,167,933(-) ttgag(A/G)tgaag utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RBMY1F Gene

Variant ID Type Subtype PubMed ID
esv2758908 CNV gain+loss 17122850
nsv10029 CNV gain 18304495
nsv10030 CNV gain 18304495
nsv10031 CNV gain 18304495
nsv1078162 CNV duplication 25765185
nsv1115940 CNV duplication 24896259
nsv1125161 CNV duplication 24896259
nsv1149864 CNV duplication 26484159
nsv1153117 CNV duplication 26484159
nsv442821 CNV loss 18776908
nsv442822 CNV loss 18776908
nsv471612 CNV loss 15918152
nsv515226 CNV loss 21397061
nsv515227 CNV loss 21397061

Relevant External Links for RBMY1F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBMY1F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RBMY1F Gene

Disorders for RBMY1F Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBMY1F Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
azoospermia
  • spermatogenic failure
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RBMY1F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBMY1F
genes like me logo Genes that share disorders with RBMY1F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBMY1F Gene

Publications for RBMY1F Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PMID: 8269511) Ma K. … Jobling M. (Cell 1993) 3 4 64
  4. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for RBMY1F Gene

Sources for RBMY1F Gene

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