Aliases for RBMY1F Gene
Aliases for RBMY1F Gene
External Ids for RBMY1F Gene
- HGNC: 23974
- Entrez Gene: 159163
- Ensembl: ENSG00000169800
- UniProtKB: Q15415
Previous GeneCards Identifiers for RBMY1F Gene
- GC0YP022795
- GC0YM022724
- GC0YM024314
Summaries for RBMY1F Gene
-
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]
GeneCards Summary for RBMY1F Gene
RBMY1F (RNA Binding Motif Protein, Y-Linked, Family 1, Member F) is a Protein Coding gene. Diseases associated with RBMY1F include Azoospermia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMY1J.
UniProtKB/Swiss-Prot for RBMY1F Gene
-
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
Additional gene information for RBMY1F Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1F Gene
Genomics for RBMY1F Gene
GeneHancer (GH) Regulatory Elements for RBMY1F Gene
Promoters and enhancers for RBMY1F Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0YI022182 | Promoter | 0.5 | EPDnew | 550.8 | +0.1 | 67 | 0.1 | RBMY1F TSPY23P LOC101929148 LOC102725532 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RBMY1F on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RBMY1F Gene
Genomic Locations for RBMY1F Gene
- chrY:22,168,181-22,183,008
- (GRCh38/hg38)
- Size:
- 14,828 bases
- Orientation:
- Minus strand
- chrY:24,314,689-24,329,129
- (GRCh37/hg19)
Genomic View for RBMY1F Gene
Genes around RBMY1F on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Yq11.223 by Ensembl
- Yq11.223 by Entrez Gene
- Yq11.223 by HGNC
RBMY1F Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RBMY1F Gene
Proteins for RBMY1F Gene
-
Protein details for RBMY1F Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15415-RBY1F_HUMAN
- Recommended name:
- RNA-binding motif protein, Y chromosome, family 1 member F/J
- Protein Accession:
- Q15415
- B2R916
Protein attributes for RBMY1F Gene
- Size:
- 496 amino acids
- Molecular mass:
- 55728 Da
- Quaternary structure:
-
- Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
- Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
- Miscellaneous:
-
- The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.
Protein Expression for RBMY1F Gene
Post-translational modifications for RBMY1F Gene
No Post-translational modifications
Other Protein References for RBMY1F Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam proteins for RBMY1F
Assay Products
No data available for DME Specific Peptides for RBMY1F Gene
Domains & Families for RBMY1F Gene
Gene Families for RBMY1F Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RBMY1F Gene
- InterPro:
- Blocks:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RBMY1F Gene
Function for RBMY1F Gene
Molecular function for RBMY1F Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | NAS,IEA | 8269511 |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0042802 | identical protein binding | IPI | 25416956 |
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miRNA for RBMY1F Gene
- miRTarBase miRNAs that target RBMY1F
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMY1F Gene
Localization for RBMY1F Gene
Subcellular locations from UniProtKB/Swiss-Prot for RBMY1F Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RBMY1F Gene
Pathways & Interactions for RBMY1F Gene
No Data Available
Interacting Proteins for RBMY1F Gene
Selected Interacting proteins:
Q15415-RBY1F_HUMAN
ENSP00000307155
for RBMY1F Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0007283 | spermatogenesis | NAS | 8269511 |
| GO:0008380 | RNA splicing | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for RBMY1F Gene
Transcripts for RBMY1F Gene
mRNA/cDNA for RBMY1F Gene
- (4) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RBMY1F Gene
CRISPR Products
-
OriGene CRISPR knockouts for RBMY1F
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-
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Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RBMY1F
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RBMY1F Gene
mRNA differential expression in normal tissues according to GTEx for RBMY1F Gene
This gene is overexpressed in Testis (x53.0).
This gene is overexpressed in Serum (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBMY1F Gene
NURSA nuclear receptor signaling pathways regulating expression of RBMY1F Gene:
RBMY1FSOURCE GeneReport for Unigene cluster for RBMY1F Gene:
Hs.567746mRNA Expression by UniProt/SwissProt for RBMY1F Gene:
Q15415-RBY1F_HUMAN
Tissue specificity:
Testis-specific.
Primer Products
-
OriGene qPCR primer pairs and template standards for RBMY1F
-
OriGene qPCR primer pairs for RBMY1F
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMY1F Gene
Orthologs for RBMY1F Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC736145 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | RBMX 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Gm3376 34 |
|
ManyToMany | |
| Gm10256 34 |
|
ManyToMany | |||
| Gm10352 34 |
|
ManyToMany | |||
| Gm21677 34 |
|
ManyToMany | |||
| Gm21693 34 |
|
ManyToMany | |||
| Gm21704 34 |
|
ManyToMany | |||
| Gm21708 34 |
|
ManyToMany | |||
| Rbmy 34 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | RBMX 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | rbmx 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | tra2 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | rsp-8 34 |
|
OneToMany |
- Species where no ortholog for RBMY1F was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for RBMY1F Gene
Paralogs for RBMY1F Gene
(13) SIMAP similar genes for RBMY1F Gene using alignment to 1 proteins:
Variants for RBMY1F Gene
| SNP ID | Clin | Chr 0Y pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1003449 | -- | 22,167,682(-) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs112554694 | -- | 22,171,848(-) | A/T | coding_sequence_variant, missense_variant | |
| rs112936698 | -- | 22,173,339(-) | C/T | intron_variant | |
| rs160738 | -- | 22,182,502(-) | T/A/C/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs161692 | -- | 22,167,933(-) | T/A/C/G | 3_prime_UTR_variant, genic_downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758908 | CNV | gain+loss | 17122850 |
| nsv10029 | CNV | gain | 18304495 |
| nsv10030 | CNV | gain | 18304495 |
| nsv10031 | CNV | gain | 18304495 |
| nsv1078162 | CNV | duplication | 25765185 |
| nsv1115940 | CNV | duplication | 24896259 |
| nsv1125161 | CNV | duplication | 24896259 |
| nsv1149864 | CNV | duplication | 26484159 |
| nsv1153117 | CNV | duplication | 26484159 |
| nsv442821 | CNV | loss | 18776908 |
| nsv442822 | CNV | loss | 18776908 |
| nsv471612 | CNV | loss | 15918152 |
| nsv515226 | CNV | loss | 21397061 |
| nsv515227 | CNV | loss | 21397061 |
Additional Variant Information for RBMY1F Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RBMY1F
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RBMY1F Gene
Disorders for RBMY1F Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| azoospermia |
|
|
Search RBMY1F in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RBMY1F
No data available for UniProtKB/Swiss-Prot and Genatlas for RBMY1F Gene
Publications for RBMY1F Gene
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PMID: 8269511) Ma K … Taylor K (Cell 1993) 3 4 58
- Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
- An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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Sources for RBMY1F Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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