RBMY1E Gene
protein-coding GIFtS: 34
GCID: GC0YM024027
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RNA binding motif protein, Y-linked, family 1, member E
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Aliases
for RBMY1E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein, Y-Linked, Family 1, Member E1 2 | | RNA-Binding Motif Protein, Y Chromosome, Family 1 Member E2 |
Export aliases for RBMY1E gene to outside databasesPrevious GC identifers: GC0YU900272 GC0YM022436 |
Summaries
for RBMY1E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBMY1E:
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine,tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region ofchromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus arepseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functionalcopies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindromeP3, along with two copies of PTPN13-like, Y-linked. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RBY1E_HUMAN, A6NEQ0Function: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly byparticipating in pre-mRNA splicing in the testis
|
Genomic Views
for RBMY1E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011903.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBMY1E gene promoter:
POU2F1 POU2F1b POU2F1a POU2F1c CUTL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBMY1E
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBMY1E |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yq11.223 Ensembl cytogenetic band: Yq11.223 HGNC cytogenetic band: Yq11.223RBMY1E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YM024027: view genomic region
(about GC identifiers)
Start:
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24,026,223 bp from pter |
End:
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24,064,214 bp from pter |
Size:
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37,992 bases |
Orientation:
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minus strand |
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Proteins
for RBMY1E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBY1E_HUMAN, A6NEQ0 (See
protein sequence)Recommended Name: RNA-binding motif protein, Y chromosome, family 1 member E Size: 496 amino acids; 55759 Da
Subunit: Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3
Subcellular location: Nucleus
Developmental stage: Expressed in all of the transcriptionally active stages of germ cell development fromspermatogonia through spermatocytes to round spermatids
Miscellaneous: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region.The exact number of functional copies is unclear and may vary between individuals, and some of them may representpseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, mostexperiments do not discriminate between the different members. One can therefore suppose that reported interactionswith a RBMY1 protein involve all the proteins
Secondary accessions: A6NCW6 A6NEG9 A6NKQ5Explore the universe of human proteins at neXtProt for RBMY1E: NX_A6NEQ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NEQ0
RBMY1E Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001006118.2
ENSEMBL proteins: ENSP00000372105 ENSP00000351823 ENSP00000372119 ENSP00000372104
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
RBMY1E for ontologies About GeneDecksing
RBMY1E Antibody Products:
Assay Products for RBMY1E: |
Protein
Domains /
Families
for RBMY1E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBMY1E for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NEQ0ProtoNet protein and cluster: A6NEQ0 UniProtKB/Swiss-Prot: RBY1E_HUMAN, A6NEQ0Similarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for RBMY1E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBY1E_HUMAN, A6NEQ0Function: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly byparticipating in pre-mRNA splicing in the testis
Clone
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In Situ Assay
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 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMY1E |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RBMY1E for ontologies About GeneDecksing
|
Pathways & Interactions
for RBMY1E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBMY1E
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
RBMY1E for ontologies About GeneDecksing
|
Drugs & Compounds
for RBMY1E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBMY1E
Search CenterWatch for drugs/clinical trials and news about RBMY1E / RBY1E
|
Transcripts
for RBMY1E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBMY1E gene: NM_001006118.2 Unigene Cluster for RBMY1E: RNA binding motif protein, Y-linked, family 1, member E Hs.725744 [show with all ESTs]Unigene Representative Sequence: NM_0010061214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382659(uc010nxd.3 uc004fux.4 uc004fuw.4 uc011nbf.2)
ENST00000358944(uc011nbg.2) ENST00000382673 ENST00000382658
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBMY1E
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBMY1E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBMY1E (NM_001006118) | | | DNA2.0 Custom Codon Optimized Gene
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7 DOTS entries: DT.92415864 DT.120654920 DT.102820644 DT.120653962 DT.120654377 DT.120654921 DT.97826649
GeneLoc Exon Structure
|
Expression
for RBMY1E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBMY1E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RBMY1E Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBMY1E
SOURCE GeneReport for Unigene cluster: Hs.725744
UniProtKB/Swiss-Prot: RBY1E_HUMAN, A6NEQ0Tissue specificity: Testis-specific
SABiosciences Custom PCR Arrays for RBMY1E
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBMY1E
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RBMY1E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBMY1E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBMY1E | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMY1E |
Orthologs
for RBMY1E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBMY1E gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for RBMY1E (if available)
TreeFam Gene Tree for RBMY1E (if available) |
Paralogs
for RBMY1E gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBMY1E gene
- RBMY1D1 2 RBMY1A11 2 RBMY1B1 2 RBMY1F1 2 RBMY1J1 2 RBMXL22 RBMXL32 TRA2B2
- RBMXL12 CIRBP2 RBM32 TRA2A2 RBMX2
18/23 SIMAP similar genes for RBMY1E using alignment to 2 protein entries: RBY1E_HUMAN (see all proteins)
(see all similar genes):RBMY1C RBMY1D RBMY1B RBMY1A1 RBMY1F RBMY1J
RBM BOLL YRRM HNRNPA1 HNRNPD RBMX
PABPC4 PABPC1 CIRBP RBMXL2 RBM38 RBMXL1
RBMY1E for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for RBMY1E (see all 8)
PGOHUM00000249967 PGOHUM00000249970 PGOHUM00000261042 PGOHUM00000233916 PGOHUM00000234009
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Genomic Variants
for RBMY1E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBMY1E (24026223 - 24064214 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for RBMY1E
8 CNVs: 97200 0832 83942 31589 83941 59626 4184 97201 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBMY1E |
|
Disorders
/ Diseases
for RBMY1E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBMY1E for disorders About GeneDecksing
2  diseases for RBMY1E: About MalaCardsazoospermia liver cancer
Export disorders for RBMY1E gene to outside databases
|
Publications
for RBMY1E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBMY1E gene integrated from 9 sources:
(articles sorted by number of sources associating them with RBMY1E) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2, 3 Skaletsky H.... Page D.C. (2003)
- RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. (PubMed id 15184870)1 Tsuei D.J....Chang M.H. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PubMed id 9598316)1 Chai N.-N.... Yen P.H. (1998)
- Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. (PubMed id 8875892)1 Prosser J.... Cooke H.J. (1996)
- A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PubMed id 8269511)1 Ma K.... Jobling M. (1993)
|
External Searches for RBMY1E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBMY1E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBMY1E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBMY1E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBMY1E | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBMY1E gene:
Search GeneIP for patents involving RBMY1E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBMY1E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMY1E |
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