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Aliases for RBMY1E Gene

Aliases for RBMY1E Gene

  • RNA Binding Motif Protein, Y-Linked, Family 1, Member E 2 3

External Ids for RBMY1E Gene

Previous GeneCards Identifiers for RBMY1E Gene

  • GC0YU900272
  • GC0YM022436
  • GC0YM024027

Summaries for RBMY1E Gene

Entrez Gene Summary for RBMY1E Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMY1E Gene

RBMY1E (RNA Binding Motif Protein, Y-Linked, Family 1, Member E) is a Protein Coding gene. Diseases associated with RBMY1E include azoospermia. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBMY1D.

UniProtKB/Swiss-Prot for RBMY1E Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1E Gene

Genomics for RBMY1E Gene

Regulatory Elements for RBMY1E Gene

Genomic Location for RBMY1E Gene

Start:
21,903,618 bp from pter
End:
21,918,093 bp from pter
Size:
14,476 bases
Orientation:
Minus strand

Genomic View for RBMY1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBMY1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMY1E Gene

Proteins for RBMY1E Gene

  • Protein details for RBMY1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NEQ0-RBY1E_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member E
    Protein Accession:
    A6NEQ0
    Secondary Accessions:
    • A6NCW6
    • A6NEG9
    • A6NKQ5

    Protein attributes for RBMY1E Gene

    Size:
    496 amino acids
    Molecular mass:
    55759 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins

neXtProt entry for RBMY1E Gene

Proteomics data for RBMY1E Gene at MOPED

Post-translational modifications for RBMY1E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMY1E Gene

Domains for RBMY1E Gene

Gene Families for RBMY1E Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBMY1E Gene

Suggested Antigen Peptide Sequences for RBMY1E Gene

Graphical View of Domain Structure for InterPro Entry

A6NEQ0

UniProtKB/Swiss-Prot:

RBY1E_HUMAN :
  • A6NEQ0
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBMY1E: view

Function for RBMY1E Gene

Molecular function for RBMY1E Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis

Gene Ontology (GO) - Molecular Function for RBMY1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBMY1E: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMY1E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RBMY1E Gene

Localization for RBMY1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMY1E Gene COMPARTMENTS Subcellular localization image for RBMY1E gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RBMY1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBMY1E: view

Pathways for RBMY1E Gene

SuperPathways for RBMY1E Gene

No Data Available

Interacting Proteins for RBMY1E Gene

Gene Ontology (GO) - Biological Process for RBMY1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with RBMY1E: view

No data available for Pathways by source for RBMY1E Gene

Transcripts for RBMY1E Gene

mRNA/cDNA for RBMY1E Gene

(7) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBMY1E Gene

RNA binding motif protein, Y-linked, family 1, member E:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMY1E

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1E Gene

No ASD Table

Relevant External Links for RBMY1E Gene

GeneLoc Exon Structure for
RBMY1E
ECgene alternative splicing isoforms for
RBMY1E

Expression for RBMY1E Gene

mRNA expression in normal human tissues for RBMY1E Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1E Gene

This gene is overexpressed in Testis (53.0).

Protein differential expression in normal tissues for RBMY1E Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RBMY1E Gene

SOURCE GeneReport for Unigene cluster for RBMY1E Gene Hs.725744

mRNA Expression by UniProt/SwissProt for RBMY1E Gene

A6NEQ0-RBY1E_HUMAN
Tissue specificity: Testis-specific
genes like me logo Genes that share expressions with RBMY1E: view

Expression partners for RBMY1E Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RBMY1E Gene

Orthologs for RBMY1E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for RBMY1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC736145 35
  • 96.98 (n)
  • 93.55 (a)
Species with no ortholog for RBMY1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RBMY1E Gene

ENSEMBL:
Gene Tree for RBMY1E (if available)
TreeFam:
Gene Tree for RBMY1E (if available)

Paralogs for RBMY1E Gene

Paralogs for RBMY1E Gene

Selected SIMAP similar genes for RBMY1E Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBMY1E: view

Variants for RBMY1E Gene

Sequence variations from dbSNP and Humsavar for RBMY1E Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs201368941 -- 21,906,156(+) CATGA(C/T)GAGTT intron-variant
rs201964579 -- 21,904,151(+) CCATA(A/G)GACAT reference, synonymous-codon
rs376306905 -- 21,906,624(+) GGACA(C/G)ATACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMY1E Gene

Variant ID Type Subtype PubMed ID
dgv2501e1 CNV Complex 17122850
dgv2502e1 CNV Complex 17122850
dgv2503e1 CNV Complex 17122850
essv23856 CNV CNV 17122850
nsv469635 CNV Loss 16826518
nsv471611 CNV Gain+Loss 15918152
nsv10026 CNV Gain 18304495
nsv819669 CNV Insertion 19587683
nsv469695 CNV Complex 16826518

Relevant External Links for RBMY1E Gene

HapMap Linkage Disequilibrium report
RBMY1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMY1E Gene

Disorders for RBMY1E Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RBMY1E Gene in MalaCards »

(1) Diseases for RBMY1E Gene including...

genes like me logo Genes that share disorders with RBMY1E: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RBMY1E Gene

Publications for RBMY1E Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4
  2. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. (PMID: 15184870) Tsuei D.J. … Chang M.H. (Oncogene 2004) 3
  3. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PMID: 8269511) Ma K. … Jobling M. (Cell 1993) 3
  4. Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. (PMID: 8875892) Prosser J. … Cooke H.J. (Mamm. Genome 1996) 3
  5. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PMID: 9598316) Chai N.-N. … Yen P.H. (Genomics 1998) 3

Products for RBMY1E Gene

Sources for RBMY1E Gene

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