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Aliases for RBMY1E Gene

Aliases for RBMY1E Gene

  • RNA Binding Motif Protein, Y-Linked, Family 1, Member E 2 3 5

External Ids for RBMY1E Gene

Previous GeneCards Identifiers for RBMY1E Gene

  • GC0YU900272
  • GC0YM022436
  • GC0YM024027

Summaries for RBMY1E Gene

Entrez Gene Summary for RBMY1E Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMY1E Gene

RBMY1E (RNA Binding Motif Protein, Y-Linked, Family 1, Member E) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMY1D.

UniProtKB/Swiss-Prot for RBMY1E Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Additional gene information for RBMY1E Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1E Gene

Genomics for RBMY1E Gene

Regulatory Elements for RBMY1E Gene


Genomic Location for RBMY1E Gene

Chromosome:
Y
Start:
21,902,181 bp from pter
End:
21,918,067 bp from pter
Size:
15,887 bases
Orientation:
Minus strand

Genomic View for RBMY1E Gene

Genes around RBMY1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMY1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMY1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMY1E Gene

Proteins for RBMY1E Gene

  • Protein details for RBMY1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NEQ0-RBY1E_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member E
    Protein Accession:
    A6NEQ0
    Secondary Accessions:
    • A6NCW6
    • A6NEG9
    • A6NKQ5

    Protein attributes for RBMY1E Gene

    Size:
    496 amino acids
    Molecular mass:
    55759 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

neXtProt entry for RBMY1E Gene

Post-translational modifications for RBMY1E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1E Gene

No data available for DME Specific Peptides for RBMY1E Gene

Domains & Families for RBMY1E Gene

Gene Families for RBMY1E Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBMY1E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RBMY1E Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBMY1E: view

No data available for UniProtKB/Swiss-Prot for RBMY1E Gene

Function for RBMY1E Gene

Molecular function for RBMY1E Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Gene Ontology (GO) - Molecular Function for RBMY1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBMY1E: view

Phenotypes for RBMY1E Gene

GenomeRNAi human phenotypes for RBMY1E:
genes like me logo Genes that share phenotypes with RBMY1E: view

Animal Model Products

CRISPR Products

miRNA for RBMY1E Gene

miRTarBase miRNAs that target RBMY1E

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBMY1E
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMY1E Gene

Localization for RBMY1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBMY1E gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RBMY1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBMY1E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RBMY1E Gene

Pathways & Interactions for RBMY1E Gene

SuperPathways for RBMY1E Gene

No Data Available

Interacting Proteins for RBMY1E Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000372105%0d%0a9606.ENSP00000303712%0d%0a9606.ENSP00000372484%0d%0a9606.ENSP00000372124%0d%0a9606.ENSP00000333024%0d%0a
Selected Interacting proteins: ENSP00000372105 A6NEQ0-RBY1E_HUMAN for RBMY1E Gene via STRING IID

Gene Ontology (GO) - Biological Process for RBMY1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with RBMY1E: view

No data available for Pathways by source and SIGNOR curated interactions for RBMY1E Gene

Drugs & Compounds for RBMY1E Gene

No Compound Related Data Available

Transcripts for RBMY1E Gene

mRNA/cDNA for RBMY1E Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBMY1E Gene

RNA binding motif protein, Y-linked, family 1, member E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBMY1E
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1E Gene

No ASD Table

Relevant External Links for RBMY1E Gene

GeneLoc Exon Structure for
RBMY1E
ECgene alternative splicing isoforms for
RBMY1E

Expression for RBMY1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBMY1E Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1E Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for RBMY1E Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBMY1E Gene



Protein tissue co-expression partners for RBMY1E Gene

NURSA nuclear receptor signaling pathways regulating expression of RBMY1E Gene:

RBMY1E

SOURCE GeneReport for Unigene cluster for RBMY1E Gene:

Hs.725744

mRNA Expression by UniProt/SwissProt for RBMY1E Gene:

A6NEQ0-RBY1E_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with RBMY1E: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMY1E Gene

Orthologs for RBMY1E Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMY1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC736145 33
  • 96.98 (n)
-- 34
  • 95 (a)
ManyToMany
-- 34
  • 94 (a)
ManyToMany
-- 34
  • 94 (a)
ManyToMany
-- 34
  • 94 (a)
ManyToMany
-- 34
  • 93 (a)
ManyToMany
-- 34
  • 93 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RBMX 34
  • 52 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm3376 34
  • 42 (a)
ManyToMany
Gm10256 34
  • 41 (a)
ManyToMany
Gm10352 34
  • 41 (a)
ManyToMany
Gm21677 34
  • 41 (a)
ManyToMany
Gm21693 34
  • 41 (a)
ManyToMany
Gm21704 34
  • 41 (a)
ManyToMany
Gm21708 34
  • 41 (a)
ManyToMany
Rbmy 34
  • 41 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RBMX 34
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 57 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rbmx 34
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tra2 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 34
  • 18 (a)
OneToMany
Species where no ortholog for RBMY1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMY1E Gene

ENSEMBL:
Gene Tree for RBMY1E (if available)
TreeFam:
Gene Tree for RBMY1E (if available)

Paralogs for RBMY1E Gene

(21) SIMAP similar genes for RBMY1E Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RBMY1E Gene

genes like me logo Genes that share paralogs with RBMY1E: view

Variants for RBMY1E Gene

Sequence variations from dbSNP and Humsavar for RBMY1E Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs1291292 -- 21,904,329(+) TCAAG(G/T)CTTTA intron-variant
rs162865 -- 21,904,151(+) CCATA(A/G)GACAT intron-variant, reference, synonymous-codon
rs201368941 -- 21,906,156(+) CATGA(C/T)GAGTT intron-variant
rs376306905 -- 21,906,624(+) GGACA(C/G)ATACT intron-variant
rs3868233 -- 21,903,464(-) GTTTT(C/G)TAATT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RBMY1E Gene

Variant ID Type Subtype PubMed ID
esv2758908 CNV gain+loss 17122850
esv3340077 CNV duplication 20981092
esv3577597 CNV gain 25503493
nsv10026 CNV gain 18304495
nsv1076748 CNV duplication 25765185
nsv1078161 CNV duplication 25765185
nsv1115938 CNV duplication 24896259
nsv1129122 CNV duplication 24896259
nsv1140100 CNV duplication 24896259
nsv1153997 CNV duplication 26484159
nsv469635 CNV loss 16826518
nsv469695 CNV loss 16826518
nsv471611 CNV gain+loss 15918152
nsv819669 CNV insertion 19587683

Relevant External Links for RBMY1E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBMY1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RBMY1E Gene

Disorders for RBMY1E Gene

Relevant External Links for RBMY1E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBMY1E

No disorders were found for RBMY1E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMY1E Gene

Publications for RBMY1E Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 2 3 4 60
  2. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. (PMID: 15184870) Tsuei DJ … Chang MH (Oncogene 2004) 3 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  4. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PMID: 9598316) Chai NN … Yen PH (Genomics 1998) 3 60
  5. Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. (PMID: 8875892) Prosser J … Cooke HJ (Mammalian genome : official journal of the International Mammalian Genome Society 1996) 3 60

Products for RBMY1E Gene

Sources for RBMY1E Gene

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