RBMY1C Gene
protein-coding GIFtS: 17
GCID: GC0YU900014
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RNA binding motif protein, Y-linked, family 1, member C(Previous names: RNA binding motif protein, Y chromosome, family 1, member...)
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Aliases
for RBMY1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| RNA Binding Motif Protein, Y-Linked, Family 1, Member C1 2 | | RNA Binding Motif Protein, Y Chromosome, Family 1, Member C1 2 | | RNA-Binding Motif Protein, Y Chromosome, Family 1 Member C2 |
Export aliases for RBMY1C gene to outside databasesPrevious GC identifers: GC0YP022827 GC0YM022871 GC0YP022011 GC0YP022083 GC0YM022438 GC0YP023673 |
Summaries
for RBMY1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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UniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4Function: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2Bto promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs
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Genomic Views
for RBMY1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RBMY1C
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBMY1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBMY1C |
Genomic Location:
Chromosome:Y
Entrez Gene cytogenetic band: Yq11.23 HGNC cytogenetic band: Yq11.23GeneLoc information about chromosome Y |
Proteins
for RBMY1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4 (See
protein sequence)Recommended Name: RNA-binding motif protein, Y chromosome, family 1 member C Size: 496 amino acids; 55784 Da
Subunit: Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3
Subcellular location: Nucleus
Developmental stage: Expressed in all of the transcriptionally active stages of germ cell development fromspermatogonia through spermatocytes to round spermatids
Miscellaneous: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region.The exact number of functional copies is unclear and may vary between individuals, and some of them may representpseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, mostexperiments do not discriminate between the different members. One can therefore suppose that reported interactionswith a RBMY1 protein involve all the proteins
Secondary accessions: Q15376 Q15377 Q15414 Q6NSB5 Q86VU6 Q8NHR0Explore the universe of human proteins at neXtProt for RBMY1C: NX_P0DJD4
RBMY1C Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
IEA | -- |
RBMY1C for ontologies About GeneDecksing
RBMY1C Antibody Products:
Assay Products for RBMY1C: |
Protein
Domains /
Families
for RBMY1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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RBMY1C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0DJD4ProtoNet protein and cluster: P0DJD4 UniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4Similarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for RBMY1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4Function: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2Bto promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs Genatlas biochemistry entry for RBMY1C:RNA binding motif protein,Y chromosome,family 1,member C,in a AZF deleted region
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- |
RBMY1C for ontologies About GeneDecksing
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Pathways & Interactions
for RBMY1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBMY1C
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
RBMY1C for ontologies About GeneDecksing
|
Drugs & Compounds
for RBMY1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for RBMY1C
Search CenterWatch for drugs/clinical trials and news about RBMY1C / RBY1C 
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Transcripts
for RBMY1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Expression
for RBMY1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See RBMY1C Protein Expression from SPIRE MOPED and PaxDBUniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4Tissue specificity: Testis-specific
SABiosciences Custom PCR Arrays for RBMY1C
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RBMY1C | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBMY1C | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBMY1C |
Orthologs
for RBMY1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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Paralogs
for RBMY1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for RBMY1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for RBMY1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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RBMY1C for disorders About GeneDecksing
2  diseases for RBMY1C: About MalaCardsazoospermia neuronitis
Export disorders for RBMY1C gene to outside databases
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Publications
for RBMY1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for RBMY1C gene integrated from 9 sources:
(articles sorted by number of sources associating them with RBMY1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PubMed id 9598316)1, 2, 3 Chai N.-N.... Yen P.H. (1998)
- RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. (PubMed id 10749975)1, 2 Venables J.P....Eperon E.C. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis. (PubMed id 15595951)2 Elliott D.J. (2004)
- T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA- binding protein implicated in spermatogenesis. (PubMed id 10332027)2 Venables J.P.... Eperon I.C. (1999)
- Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm. (PubMed id 9108067)2 Elliott D.J.... Cooke H. (1997)
- A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PubMed id 8269511)1 Ma K.... Jobling M. (1993)
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External Searches for RBMY1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RBMY1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing RBMY1C gene
(According to HUGE)
About This Section
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Specialized Databases showing RBMY1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBMY1C | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RBMY1C gene:
Search GeneIP for patents involving RBMY1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBMY1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBMY1C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBMY1C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBMY1C | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBMY1C | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBMY1C | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBMY1C |
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| | | | Search Tocris compounds for RBMY1C |
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 | | | RBMY1C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RBMY1C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBMY1C |
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