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RBMY1C Gene

protein-coding   GIFtS: 17
GCID: GC0YU900014

RNA Binding Motif Protein, Y-Linked, Family 1, Member C

(Previous names: RNA binding motif protein, Y chromosome, family 1, member...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Motif Protein, Y-Linked, Family 1, Member C1 2
RNA Binding Motif Protein, Y Chromosome, Family 1, Member C1 2
RNA-Binding Motif Protein, Y Chromosome, Family 1 Member C2

External Ids:    HGNC: 99141   Entrez Gene: 59422   UniProtKB: P0DJD43   

Export aliases for RBMY1C gene to outside databases

Previous GC identifers: GC0YP022827 GC0YM022871 GC0YP022011 GC0YP022083 GC0YM022438 GC0YP023673


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RBMY1C Gene:
RBMY1C (RNA binding motif protein, Y-linked, family 1, member C) is a protein-coding gene. Diseases associated with RBMY1C include azoospermia, and neuronitis. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4
Function: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with
TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for RBMY1C
         Other transcription factors

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Epigenetics:
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Genomic Location:
Chromosome:Y   

Entrez Gene cytogenetic band: Yq11.23   HGNC cytogenetic band: Yq11.23

GeneLoc information about chromosome Y        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4 (See protein sequence)
Recommended Name: RNA-binding motif protein, Y chromosome, family 1 member C  
Size: 496 amino acids; 55784 Da
Subunit: Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3
Developmental stage: Expressed in all of the transcriptionally active stages of germ cell development from
spermatogonia through spermatocytes to round spermatids
Miscellaneous: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb
region. The exact number of functional copies is unclear and may vary between individuals, and some of them may
represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult.
Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported
interactions with a RBMY1 protein involve all the proteins
Secondary accessions: Q15376 Q15377 Q15414 Q6NSB5 Q86VU6 Q8NHR0

Explore the universe of human proteins at neXtProt for RBMY1C: NX_P0DJD4

Explore proteomics data for RBMY1C at MOPED


See RBMY1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RBM: RNA binding motif (RRM) containing

3 InterPro protein domains:
 IPR012604 RBM1CTR
 IPR012677 Nucleotide-bd_a/b_plait
 IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry P0DJD4

ProtoNet protein and cluster: P0DJD4

UniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4
Similarity: Contains 1 RRM (RNA recognition motif) domain


RBMY1C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RBY1C_HUMAN, P0DJD4
Function: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with
TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs

     Genatlas biochemistry entry for RBMY1C:
RNA binding motif protein,Y chromosome,family 1,member C,in a AZF deleted region

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding IEA--
GO:0003723RNA binding IEA--
     
RBMY1C for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RBY1C_HUMAN, P0DJD4: Nucleus

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

RBMY1C for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006397mRNA processing IEA--
GO:0008380RNA splicing IEA--

RBMY1C for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

RBMY1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RBMY1C Protein Expression

UniProtKB/Swiss-Prot: RBY1C_HUMAN, P0DJD4
Tissue specificity: Testis-specific

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RBMY1C gene
Selected SIMAP similar genes for RBMY1C using alignment to 1 protein entry:     RBY1C_HUMAN(see all similar genes):
RBMY1B    RBMY1A1    RBMY1F    RBMY1D    RBMY1E    RBMY1J
RBM    BOLL    YRRM    RBM7    PABPC4    PABPC1
CIRBP    RBMX    RBM38    RBMXL2    RBM3    SFRS3

RBMY1C for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing RBMY1C
DNA2.0 Custom Variant and Variant Library Synthesis for RBMY1C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for RBMY1C:    About MalaCards
azoospermia    neuronitis


RBMY1C for disorders           About GeneDecksing


Export disorders for RBMY1C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RBMY1C gene integrated from 10 sources:
(articles sorted by number of sources associating them with RBMY1C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PubMed id 9598316)1, 2, 3 Chai N.-N.... Yen P.H. (Genomics 1998)
  2. RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. (PubMed id 10749975)1, 2 Venables J.P....Eperon E.C. (Hum. Mol. Genet. 2000)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis. (PubMed id 15595951)2 Elliott D.J. (Int. J. Androl. 2004)
  5. T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA- binding protein implicated in spermatogenesis. (PubMed id 10332027)2 Venables J.P.... Eperon I.C. (Hum. Mol. Genet. 1999)
  6. Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm. (PubMed id 9108067)2 Elliott D.J.... Cooke H. (Proc. Natl. Acad. Sci. U.S.A. 1997)
  7. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PubMed id 8269511)1 Ma K.... Jobling M. (Cell 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5942 HGNC: 9914 euGenes: HUgn5942 ECgene: RBMY1C H-InvDB: RBMY1C

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RBMY1C Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RBMY1C gene:
Search GeneIP for patents involving RBMY1C

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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