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Aliases for RBMY1B Gene

Aliases for RBMY1B Gene

  • RNA Binding Motif Protein, Y-Linked, Family 1, Member B 2 3 5

External Ids for RBMY1B Gene

Previous GeneCards Identifiers for RBMY1B Gene

  • GC0YU900270
  • GC0YP022082
  • GC0YP023674
  • GC0YP023679

Summaries for RBMY1B Gene

Entrez Gene Summary for RBMY1B Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]

GeneCards Summary for RBMY1B Gene

RBMY1B (RNA Binding Motif Protein, Y-Linked, Family 1, Member B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CIRBP.

UniProtKB/Swiss-Prot for RBMY1B Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1B Gene

Genomics for RBMY1B Gene

Regulatory Elements for RBMY1B Gene

Genomic Location for RBMY1B Gene

Chromosome:
Y
Start:
21,511,338 bp from pter
End:
21,549,094 bp from pter
Size:
37,757 bases
Orientation:
Plus strand

Genomic View for RBMY1B Gene

Genes around RBMY1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMY1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMY1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMY1B Gene

Proteins for RBMY1B Gene

  • Protein details for RBMY1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDE4-RBY1B_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member B
    Protein Accession:
    A6NDE4
    Secondary Accessions:
    • A6NCZ8
    • A6NE80
    • A8MSJ6

    Protein attributes for RBMY1B Gene

    Size:
    496 amino acids
    Molecular mass:
    55835 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

neXtProt entry for RBMY1B Gene

Proteomics data for RBMY1B Gene at MOPED

Post-translational modifications for RBMY1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1B Gene

No data available for DME Specific Peptides for RBMY1B Gene

Domains & Families for RBMY1B Gene

Gene Families for RBMY1B Gene

Protein Domains for RBMY1B Gene

Suggested Antigen Peptide Sequences for RBMY1B Gene

Graphical View of Domain Structure for InterPro Entry

A6NDE4

UniProtKB/Swiss-Prot:

RBY1B_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBMY1B: view

Function for RBMY1B Gene

Molecular function for RBMY1B Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Gene Ontology (GO) - Molecular Function for RBMY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RBMY1B: view

Phenotypes for RBMY1B Gene

GenomeRNAi human phenotypes for RBMY1B:
genes like me logo Genes that share phenotypes with RBMY1B: view

Animal Model Products

CRISPR Products

miRNA for RBMY1B Gene

miRTarBase miRNAs that target RBMY1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMY1B Gene

Localization for RBMY1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMY1B Gene COMPARTMENTS Subcellular localization image for RBMY1B gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for RBMY1B Gene

Pathways & Interactions for RBMY1B Gene

SuperPathways for RBMY1B Gene

No Data Available

Interacting Proteins for RBMY1B Gene

Gene Ontology (GO) - Biological Process for RBMY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008584 male gonad development IMP 9598316
genes like me logo Genes that share ontologies with RBMY1B: view

No data available for Pathways by source and SIGNOR curated interactions for RBMY1B Gene

Drugs & Compounds for RBMY1B Gene

No Compound Related Data Available

Transcripts for RBMY1B Gene

mRNA/cDNA for RBMY1B Gene

(7) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1B Gene

No ASD Table

Relevant External Links for RBMY1B Gene

GeneLoc Exon Structure for
RBMY1B
ECgene alternative splicing isoforms for
RBMY1B

Expression for RBMY1B Gene

mRNA expression in normal human tissues for RBMY1B Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1B Gene

This gene is overexpressed in Testis (x51.2).

Protein differential expression in normal tissues from HIPED for RBMY1B Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RBMY1B Gene



mRNA Expression by UniProt/SwissProt for RBMY1B Gene

A6NDE4-RBY1B_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with RBMY1B: view

Protein tissue co-expression partners for RBMY1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RBMY1B Gene

Orthologs for RBMY1B Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMY1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC736145 35
  • 97.18 (n)
  • 93.95 (a)
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia RBMX 36
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10256 36
  • 41 (a)
ManyToMany
Gm10352 36
  • 41 (a)
ManyToMany
Gm21677 36
  • 41 (a)
ManyToMany
Gm21693 36
  • 41 (a)
ManyToMany
Gm21704 36
  • 41 (a)
ManyToMany
Gm21708 36
  • 41 (a)
ManyToMany
Gm3376 36
  • 42 (a)
ManyToMany
Rbmy 36
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves RBMX 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rbmx 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tra2 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 36
  • 18 (a)
OneToMany
Species with no ortholog for RBMY1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMY1B Gene

ENSEMBL:
Gene Tree for RBMY1B (if available)
TreeFam:
Gene Tree for RBMY1B (if available)

Paralogs for RBMY1B Gene

(12) SIMAP similar genes for RBMY1B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RBMY1B Gene

genes like me logo Genes that share paralogs with RBMY1B: view

Variants for RBMY1B Gene

Sequence variations from dbSNP and Humsavar for RBMY1B Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs796800589 -- 21,523,217(+) TGGAT(C/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMY1B Gene

Variant ID Type Subtype PubMed ID
dgv2501e1 CNV Complex 17122850
dgv2502e1 CNV Complex 17122850
dgv2503e1 CNV Complex 17122850
essv23856 CNV CNV 17122850
nsv469635 CNV Loss 16826518
nsv471611 CNV Gain+Loss 15918152
nsv10026 CNV Gain 18304495
nsv819669 CNV Insertion 19587683
nsv469695 CNV Complex 16826518

Relevant External Links for RBMY1B Gene

HapMap Linkage Disequilibrium report
RBMY1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RBMY1B Gene

Disorders for RBMY1B Gene

Relevant External Links for RBMY1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBMY1B

No disorders were found for RBMY1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMY1B Gene

Publications for RBMY1B Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4 67
  2. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. (PMID: 15184870) Tsuei D.J. … Chang M.H. (Oncogene 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. (PMID: 10749975) Venables J.P. … Eperon E.C. (Hum. Mol. Genet. 2000) 3
  5. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PMID: 9598316) Chai N.-N. … Yen P.H. (Genomics 1998) 3

Products for RBMY1B Gene

Sources for RBMY1B Gene

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