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Aliases for RBMY1B Gene

Aliases for RBMY1B Gene

  • RNA Binding Motif Protein, Y-Linked, Family 1, Member B 2 3

External Ids for RBMY1B Gene

Previous GeneCards Identifiers for RBMY1B Gene

  • GC0YU900270
  • GC0YP022082
  • GC0YP023674
  • GC0YP023679

Summaries for RBMY1B Gene

Entrez Gene Summary for RBMY1B Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMY1B Gene

RBMY1B (RNA Binding Motif Protein, Y-Linked, Family 1, Member B) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBMY1D.

UniProtKB/Swiss-Prot for RBMY1B Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMY1B Gene

Genomics for RBMY1B Gene

Regulatory Elements for RBMY1B Gene

Genomic Location for RBMY1B Gene

Start:
21,511,312 bp from pter
End:
21,525,786 bp from pter
Size:
14,475 bases
Orientation:
Plus strand

Genomic View for RBMY1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBMY1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMY1B Gene

Proteins for RBMY1B Gene

  • Protein details for RBMY1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDE4-RBY1B_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member B
    Protein Accession:
    A6NDE4
    Secondary Accessions:
    • A6NCZ8
    • A6NE80
    • A8MSJ6

    Protein attributes for RBMY1B Gene

    Size:
    496 amino acids
    Molecular mass:
    55835 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins

neXtProt entry for RBMY1B Gene

Proteomics data for RBMY1B Gene at MOPED

Post-translational modifications for RBMY1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMY1B Gene

Domains for RBMY1B Gene

Gene Families for RBMY1B Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBMY1B Gene

Suggested Antigen Peptide Sequences for RBMY1B Gene

Graphical View of Domain Structure for InterPro Entry

A6NDE4

UniProtKB/Swiss-Prot:

RBY1B_HUMAN :
  • A6NDE4
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBMY1B: view

Function for RBMY1B Gene

Molecular function for RBMY1B Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis

Gene Ontology (GO) - Molecular Function for RBMY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 9598316
GO:0005515 protein binding IPI 10749975
genes like me logo Genes that share ontologies with RBMY1B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RBMY1B Gene

Localization for RBMY1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMY1B Gene COMPARTMENTS Subcellular localization image for RBMY1B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RBMY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9598316
genes like me logo Genes that share ontologies with RBMY1B: view

Pathways for RBMY1B Gene

SuperPathways for RBMY1B Gene

No Data Available

Interacting Proteins for RBMY1B Gene

Gene Ontology (GO) - Biological Process for RBMY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0007283 spermatogenesis TAS 9598316
GO:0008380 RNA splicing IDA 10749975
GO:0008584 male gonad development IMP 9598316
genes like me logo Genes that share ontologies with RBMY1B: view

No data available for Pathways by source for RBMY1B Gene

Transcripts for RBMY1B Gene

mRNA/cDNA for RBMY1B Gene

(6) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMY1B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RBMY1B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1B Gene

No ASD Table

Relevant External Links for RBMY1B Gene

GeneLoc Exon Structure for
RBMY1B
ECgene alternative splicing isoforms for
RBMY1B

Expression for RBMY1B Gene

mRNA expression in normal human tissues for RBMY1B Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1B Gene

This gene is overexpressed in Testis (51.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RBMY1B Gene

mRNA Expression by UniProt/SwissProt for RBMY1B Gene

A6NDE4-RBY1B_HUMAN
Tissue specificity: Testis-specific
genes like me logo Genes that share expressions with RBMY1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RBMY1B Gene

Orthologs for RBMY1B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for RBMY1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC736145 35
  • 97.18 (n)
  • 93.95 (a)
Species with no ortholog for RBMY1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RBMY1B Gene

ENSEMBL:
Gene Tree for RBMY1B (if available)
TreeFam:
Gene Tree for RBMY1B (if available)

Paralogs for RBMY1B Gene

Paralogs for RBMY1B Gene

Selected SIMAP similar genes for RBMY1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RBMY1B: view

Variants for RBMY1B Gene

Structural Variations from Database of Genomic Variants (DGV) for RBMY1B Gene

Variant ID Type Subtype PubMed ID
dgv2501e1 CNV Complex 17122850
dgv2502e1 CNV Complex 17122850
dgv2503e1 CNV Complex 17122850
essv23856 CNV CNV 17122850
nsv469635 CNV Loss 16826518
nsv471611 CNV Gain+Loss 15918152
nsv10026 CNV Gain 18304495
nsv819669 CNV Insertion 19587683
nsv469695 CNV Complex 16826518

Relevant External Links for RBMY1B Gene

HapMap Linkage Disequilibrium report
RBMY1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RBMY1B Gene

Disorders for RBMY1B Gene

No disorders were found for RBMY1B Gene.

No data available for UniProtKB/Swiss-Prot for RBMY1B Gene

Publications for RBMY1B Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4
  2. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. (PMID: 15184870) Tsuei D.J. … Chang M.H. (Oncogene 2004) 3
  3. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PMID: 8269511) Ma K. … Jobling M. (Cell 1993) 3
  4. Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. (PMID: 8875892) Prosser J. … Cooke H.J. (Mamm. Genome 1996) 3
  5. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. (PMID: 9598316) Chai N.-N. … Yen P.H. (Genomics 1998) 3

Products for RBMY1B Gene

Sources for RBMY1B Gene

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