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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBMXL2 Gene

protein-coding   GIFtS: 47
GCID: GC11P007068

RNA binding motif protein, X-linked-like 2

 Explore 3 diseases affiliated with
RBMXL2 via our new
 Human Malady Compendium 
Biological research products
for RBMXL2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RNA Binding Motif Protein, X-Linked-Like 21 2     HnRNP G-T2 3
HNRPGT1 2 5     Heterogeneous Nuclear Ribonucleoprotein G T2
HNRNPGT2 3 5     RNA-Binding Motif Protein, X-Linked-Like-22
HNRNPG-T1 2     Testes Specific Heterogenous Nuclear Ribonucleoprotein G T2
Testis-Specific Heterogeneous Nuclear Ribonucleoprotein G-T2 3     Testes-Specific Heterogenous Nuclear Ribonucleoprotein G-T2

External Ids:    HGNC: 178861   Entrez Gene: 272882   Ensembl: ENSG000001707487   OMIM: 6054445   UniProtKB: O755263   

Export aliases for RBMXL2 gene to outside databases

Previous GC identifer: GC11P006768


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBMXL2:
This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus
and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene
has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon.
However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to
HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ
cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a
candidate for autosomal male infertility. (provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBMXL2 gene promoter:
         RFX1   AML1a   NF-YA   C/EBPalpha   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBMXL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBMXL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBMXL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

RBMXL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBMXL2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P007068:  view genomic region     (about GC identifiers)

Start:
7,110,165 bp from pter      End:
7,112,379 bp from pter
Size:
2,215 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RMXL2_HUMAN, O75526 (See protein sequence)
Recommended Name: RNA-binding motif protein, X-linked-like-2  
Size: 392 amino acids; 42814 Da
Subcellular location: Nucleus
Secondary accessions: Q6PEZ2 Q9NQU0

Explore the universe of human proteins at neXtProt for RBMXL2: NX_O75526

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75526

  • RBMXL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055284.3  
    ENSEMBL proteins: 
     ENSP00000304139  

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    Uscn Proteins for RBMXL2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0030529ribonucleoprotein complex IEA--


    RBMXL2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RBMXL2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012604 RBM1CTR
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O75526

    ProtoNet protein and cluster: O75526

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB012604 RBM1CTR


    UniProtKB/Swiss-Prot: RMXL2_HUMAN, O75526
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--


    RBMXL2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBMXL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/45 Interacting proteins for RBMXL2 (O755263 ENSP000003041394) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYRK2Q926303, ENSP000003421054I2D: score=1 STRING: ENSP00000342105
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    TRA2BP629953, ENSP000004169594I2D: score=2 STRING: ENSP00000416959
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    GABARAPO951663I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBMXL2
    Search CenterWatch for drugs/clinical trials and news about RBMXL2 / RMXL2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RBMXL2 gene: 
    NM_014469.4  

    Unigene Cluster for RBMXL2:

    RNA binding motif protein, X-linked-like 2
    Hs.121605  [show with all ESTs]
    Unigene Representative Sequence: NM_014469
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306904(uc001mfc.2)

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    hsa-miR-653 hsa-miR-92a-1* hsa-miR-548s hsa-miR-488 hsa-miR-133b hsa-miR-3926 hsa-miR-374a* hsa-miR-133a
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    Additional cDNA sequence: 

    AF069682.2 AK292271.1 BC029295.1 BC057796.1 

    2 DOTS entries:

    DT.100672874  DT.107193 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBMXL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAGGGGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    RBMXL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See RBMXL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBMXL2

    SOURCE GeneReport for Unigene cluster: Hs.121605

    UniProtKB/Swiss-Prot: RMXL2_HUMAN, O75526
    Tissue specificity: Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed
    in germ cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBMXL2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RBMX6
    Uncharacterized protein
    73(a)
    1 → many
    4(4422127-4432978)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    72(a)
    1 → many
    GL343562.1(327279-334430)
    zebrafish
    (Danio rerio)
    Actinopterygii rbmx6
    RNA binding motif protein, X-linked
    61(a)
    1 → many
    14(32725471-32732600)
    worm
    (Caenorhabditis elegans)
    Secernentea R09B3.36
    R09B3.26
    (see all 4)
    Protein R09B3.2
    (see all 4)
    32(a)
    31(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    I(11910319-11911012)
    I(11909347-11910095)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G209306
    AT3G460206
    (see all 21)
    RNA recognition motif-containing protein
    (see all 21)
    8(a)
    29(a)
    (see all 21)
    many ↔ many
    many ↔ many
    (see all 21)
    3(7331721-7334029)
    3(16912344-16913350)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 20)
    RNA recognition motif family protein, expressed
    (see all 20)
    9(a)
    8(a)
    (see all 20)
    many ↔ many
    many ↔ many
    (see all 20)
    7(24609207-24612695)
    2(30439027-30442556)


    ENSEMBL Gene Tree for RBMXL2 (if available)
    TreeFam Gene Tree for RBMXL2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RBMXL2 gene
    RBMY1E2  RBMY1J2  RBMY1F2  RBMXL32  TRA2B2  RBMY1B2  RBMXL12  RBMY1A12  
    CIRBP2  RBM32  TRA2A2  RBMX2  RBMY1D2  
    16 SIMAP similar genes for RBMXL2 using alignment to 1 protein entry:     RMXL2_HUMAN:
    RBMX    RBM    RBMXL1    HNRNPA1    RBMXL3    CIRBP
    RBM3    RBMY1F    RBMY1J    RBMY1D    RBMY1E    RBMY1A1
    RBMY1B    RBMY1C    RBM38    SFRS3

    RBMXL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/101 NCBI SNPs in RBMXL2 are shown (see all 101    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs763739571,2
    F,--7108246(+) AAACAG/ATTCCA 1 -- us2k11Minor allele frequency- A:0.12EA 120
    rs1445951481,2
    --7108248(+) ACAGTC/TCCACA 1 -- us2k10--------
    rs714704601,2
    C,F,--7108268(+) ACCTCAGATA/
            
    AGAGG
    1 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs601150321,2
    C--7108271(+) TCAGA-/TAAGA 
            
    GGGAA
    1 -- us2k11Minor allele frequency- TAAGA:0.00NA 2
    rs2001702511,2
    C--7108272(-) CCTCTG/TANNNN 1 -- us2k10--------
    rs764281691,2
    F,--7108311(+) TCTTTG/ATTCTA 1 -- us2k11Minor allele frequency- A:0.12WA 118
    rs740509301,2
    C,--7108342(+) GGATGG/CAGTCA 1 -- us2k13Minor allele frequency- C:0.06WA NA 240
    rs124193901,2
    C,H,--7108403(+) TTCACC/TAACTG 1 -- us2k1 tfbs32Minor allele frequency- T:0.12NA EA 126
    rs1144942561,2
    F,--7108548(+) GAAATT/GTACAT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1833398741,2
    --7108552(+) TTTACA/TTTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RBMXL2 (7110165 - 7112379 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RBMXL2: --
    Human Gene Mutation Database (HGMD): RBMXL2

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RBMXL2 for disorders           About GeneDecksing

    OMIM gene information: 605444    OMIM disorders: --

    3 diseases for RBMXL2:    About MalaCards
    male infertility    infertility    endometrial cancer

    1 disease from the University of Copenhagen DISEASES database for RBMXL2:
    Male infertility

    Export disorders for RBMXL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBMXL2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RBMXL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene. (PubMed id 10958650)1, 2, 3 Elliott D.J.... Cooke H.J. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Localization of the germ cell-specific protein, hnRNP G-T, in testicular biopsies of azoospermic men. (PubMed id 12389739)1, 9 Maymon B.B....Yavetz H. (2002)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Expression levels of hnRNP G and hTra2-beta1 correlat e with opposite outcomes in endometrial cancer biology. (PubMed id 20607830)1 Ouyang Y.Q....Stickeler E. (2011)
    6. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    7. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    8. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (2010)
    9. Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts. (PubMed id 21327109)1 Kanhoush R....Penrad-Mobayed M. (2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27288 HGNC: 17886 Ensembl:ENSG00000170748 euGenes: HUgn27288 ECgene: RBMXL2
    H-InvDB: RBMXL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBMXL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBMXL2 gene:
    Search GeneIP for patents involving RBMXL2

    GeneCards and IP:
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