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Aliases for RBMXL2 Gene

Aliases for RBMXL2 Gene

  • RNA Binding Motif Protein, X-Linked-Like 2 2 3
  • Testis-Specific Heterogeneous Nuclear Ribonucleoprotein G-T 3 4
  • Heterogeneous Nuclear Ribonucleoprotein G T 2 3
  • HnRNP G-T 3 4
  • HNRNPGT 3 4
  • Testes Specific Heterogenous Nuclear Ribonucleoprotein G T 3
  • Testes-Specific Heterogenous Nuclear Ribonucleoprotein G-T 3
  • HNRNPG-T 3
  • HNRPGT 3

External Ids for RBMXL2 Gene

Previous GeneCards Identifiers for RBMXL2 Gene

  • GC11P006768

Summaries for RBMXL2 Gene

Entrez Gene Summary for RBMXL2 Gene

  • This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMXL2 Gene

RBMXL2 (RNA Binding Motif Protein, X-Linked-Like 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMXL1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMXL2 Gene

Genomics for RBMXL2 Gene

Regulatory Elements for RBMXL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBMXL2 Gene

7,088,934 bp from pter
7,091,148 bp from pter
2,215 bases
Plus strand

Genomic View for RBMXL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBMXL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMXL2 Gene

Proteins for RBMXL2 Gene

  • Protein details for RBMXL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding motif protein, X-linked-like-2
    Protein Accession:
    Secondary Accessions:
    • Q6PEZ2
    • Q9NQU0

    Protein attributes for RBMXL2 Gene

    392 amino acids
    Molecular mass:
    42814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBMXL2 Gene

Proteomics data for RBMXL2 Gene at MOPED

Post-translational modifications for RBMXL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMXL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMXL2 Gene

Domains & Families for RBMXL2 Gene

Gene Families for RBMXL2 Gene

Protein Domains for RBMXL2 Gene

Suggested Antigen Peptide Sequences for RBMXL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBMXL2: view

Function for RBMXL2 Gene

Gene Ontology (GO) - Molecular Function for RBMXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBMXL2: view

Phenotypes for RBMXL2 Gene

genes like me logo Genes that share phenotypes with RBMXL2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBMXL2 Gene

Localization for RBMXL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMXL2 Gene

Subcellular locations from

Jensen Localization Image for RBMXL2 Gene COMPARTMENTS Subcellular localization image for RBMXL2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for RBMXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RBMXL2: view

Pathways & Interactions for RBMXL2 Gene

SuperPathways for RBMXL2 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RBMXL2: view

Pathways by source for RBMXL2 Gene

1 KEGG pathway for RBMXL2 Gene

Gene Ontology (GO) - Biological Process for RBMXL2 Gene


No data available for SIGNOR curated interactions for RBMXL2 Gene

Drugs & Compounds for RBMXL2 Gene

No Compound Related Data Available

Transcripts for RBMXL2 Gene

mRNA/cDNA for RBMXL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBMXL2 Gene

RNA binding motif protein, X-linked-like 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMXL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMXL2 Gene

No ASD Table

Relevant External Links for RBMXL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBMXL2 Gene

mRNA expression in normal human tissues for RBMXL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBMXL2 Gene

This gene is overexpressed in Testis (x50.5).

Protein differential expression in normal tissues from HIPED for RBMXL2 Gene

This gene is overexpressed in Testis (18.4), Monocytes (15.2), Liver, secretome (13.6), Ovary (11.4), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBMXL2 Gene

SOURCE GeneReport for Unigene cluster for RBMXL2 Gene Hs.121605

mRNA Expression by UniProt/SwissProt for RBMXL2 Gene

Tissue specificity: Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed in germ cells.
genes like me logo Genes that share expression patterns with RBMXL2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein tissue co-expression partners for RBMXL2 Gene

Orthologs for RBMXL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMXL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rbmxl2 35
  • 80.02 (n)
  • 80.39 (a)
Rbmxl2 16
Rbmxl2 36
  • 82 (a)
(Pan troglodytes)
Mammalia RBMXL2 35
  • 99.06 (n)
  • 98.72 (a)
  • 99 (a)
(Bos Taurus)
Mammalia RBMX 36
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
(Gallus gallus)
Aves RBMX 36
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
(Danio rerio)
Actinopterygii rbmx 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta tra2 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea rsp-8 36
  • 22 (a)
Species with no ortholog for RBMXL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMXL2 Gene

Gene Tree for RBMXL2 (if available)
Gene Tree for RBMXL2 (if available)

Paralogs for RBMXL2 Gene

(16) SIMAP similar genes for RBMXL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RBMXL2: view

Variants for RBMXL2 Gene

Sequence variations from dbSNP and Humsavar for RBMXL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs17854944 - 7,090,043(+) CCGCT(A/G)CGAGG reference, missense
rs61881489 -- 7,090,999(+) TACTA(C/T)ATCAA utr-variant-3-prime
rs77496887 -- 7,089,663(+) AGGGC(C/T)CTGGC reference, synonymous-codon
rs138299235 -- 7,090,805(+) ACCAG(-/CAA)CAACA cds-indel
rs138499352 -- 7,090,231(+) GCTGC(A/C)GGGTG reference, synonymous-codon

Variation tolerance for RBMXL2 Gene

Residual Variation Intolerance Score: 76.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBMXL2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RBMXL2 Gene

Disorders for RBMXL2 Gene

Relevant External Links for RBMXL2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RBMXL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMXL2 Gene

Publications for RBMXL2 Gene

  1. The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis. (PMID: 15595951) Elliott D.J. (Int. J. Androl. 2004) 23 67
  2. Heterogeneous nuclear ribonucleoprotein G-T (HNRNP G-T) mutations in men with impaired spermatogenesis. (PMID: 14996998) Westerveld G.H. … Lombardi M.P. (Mol. Hum. Reprod. 2004) 23 67
  3. Localization of the germ cell-specific protein, hnRNP G-T, in testicular biopsies of azoospermic men. (PMID: 12389739) Maymon B.B. … Yavetz H. (Acta Histochem. 2002) 23 67
  4. An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene. (PMID: 10958650) Elliott D.J. … Cooke H.J. (Hum. Mol. Genet. 2000) 2 67
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 67

Products for RBMXL2 Gene

Sources for RBMXL2 Gene

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