RBMXL2 Gene
protein-coding GIFtS : 47
GCID: GC11 P007068
RNA binding motif protein, X-linked-like 2
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Aliasesfor RBMXL2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RNA Binding Motif Protein, X-Linked-Like 2 1 2 HnRNP G-T2 3 HNRPGT1 2 5 Heterogeneous Nuclear Ribonucleoprotein G T2 HNRNPGT2 3 5 RNA-Binding Motif Protein, X-Linked-Like-22 HNRNPG-T1 2 Testes Specific Heterogenous Nuclear Ribonucleoprotein G T2 Testis-Specific Heterogeneous Nuclear Ribonucleoprotein G-T2 3 Testes-Specific Heterogenous Nuclear Ribonucleoprotein G-T2
Export aliases for RBMXL2 gene to outside databases Previous GC identifer: GC11P006768
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Summariesfor RBMXL2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RBMXL2 : This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. (provided by RefSeq, Jul 2008)
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Genomic Viewsfor RBMXL2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RBMXL2 gene promoter: RFX1 AML1a NF-YA C/EBPalpha NF-YB CBF-A CBF-B CP1A NF-Y CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for RBMXL2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RBMXL2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15 RBMXL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P007068: view genomic region
(about GC identifiers )
Start:
7,110,165 bp from pter
End:
7,112,379 bp from pter
Size:
2,215 bases
Orientation:
plus strand
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Proteinsfor RBMXL2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RMXL2_HUMAN, O75526 (See
protein sequence )Recommended Name: RNA-binding motif protein, X-linked-like-2 Size : 392 amino acids; 42814 Da
Subcellular location : Nucleus
Secondary accessions : Q6PEZ2 Q9NQU0Explore the universe of human proteins at neXtProt for RBMXL2: NX_O75526 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O75526 RBMXL2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_055284.3 ENSEMBL proteins: ENSP00000304139 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
RBMXL2 for ontologies About GeneDecksing RBMXL2 Antibody Products: Assay Products for RBMXL2:
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Protein
Domains / Familiesfor RBMXL2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RBMXL2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O75526 ProtoNet protein and cluster: O75526
2 Blocks protein families : IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB012604 RBM1CTR UniProtKB/Swiss-Prot: RMXL2_HUMAN, O75526 Similarity : Contains 1 RRM (RNA recognition motif) domain
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Functionfor RBMXL2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RBMXL2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RBMXL2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RBMXL2 (NM_014469 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBMXL2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBMXL2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMXL2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding
IEA -- GO:0003723 RNA binding
IEA --
RBMXL2 for ontologies About GeneDecksing
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Pathways & Interactionsfor RBMXL2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBMXL2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/45 Interacting proteins for RBMXL2 (O75526 3 ENSP00000304139 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 45 )About this table
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Drugs & Compoundsfor RBMXL2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RBMXL2 Search CenterWatch for drugs/clinical trials and news about RBMXL2 / RMXL2
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Transcriptsfor RBMXL2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
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Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RBMXL2 gene: NM_014469.4 Unigene Cluster for RBMXL2:
RNA binding motif protein, X-linked-like 2 Hs.121605 [show with all ESTs ] Unigene Representative Sequence: NM_014469 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000306904 (uc001mfc.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RBMXL2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RBMXL2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RBMXL2 (NM_014469 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBMXL2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBMXL2
Additional cDNA sequence: AF069682.2 AK292271.1 BC029295.1 BC057796.1
2 DOTS entries : DT.100672874 DT.107193
GeneLoc Exon Structure
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Expression for RBMXL2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RBMXL2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAAAGGGGCT
About this image RBMXL2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Brain Blood Brain Barrier Adult Endothelial Cells Blood Brain Barrier, Endothelium Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
See RBMXL2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RBMXL2 SOURCE GeneReport for Unigene cluster: Hs.121605 UniProtKB/Swiss-Prot: RMXL2_HUMAN, O75526 Tissue specificity : Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressedin germ cells SABiosciences Custom PCR Arrays for RBMXL2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RBMXL2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat RBMXL2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RBMXL2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RBMXL2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMXL2
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Orthologsfor RBMXL2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBMXL2 gene from 6/16 species (see all 16 ) About this table
ENSEMBL Gene Tree for RBMXL2 (if available)TreeFam Gene Tree for RBMXL2 (if available)
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Paralogsfor RBMXL2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RBMXL2 gene RBMY1E 2 RBMY1J 2 RBMY1F 2 RBMXL3 2 TRA2B 2 RBMY1B 2 RBMXL1 2 RBMY1A1 2 CIRBP 2 RBM3 2 TRA2A 2 RBMX 2 RBMY1D 2 16 SIMAP similar genes for RBMXL2 using alignment to 1 protein entry: RMXL2_HUMAN :RBMX RBM RBMXL1 HNRNPA1 RBMXL3 CIRBP RBM3 RBMY1F RBMY1J RBMY1D RBMY1E RBMY1A1 RBMY1B RBMY1C RBM38 SFRS3
RBMXL2 for paralogs About GeneDecksing
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Genomic Variantsfor RBMXL2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RBMXL2 (7110165 - 7112379 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RBMXL2: -- Human Gene Mutation Database (HGMD) : RBMXL2 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RBMXL2
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Disorders
/ Diseasesfor RBMXL2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RBMXL2 for disorders About GeneDecksing
OMIM gene information: 605444
OMIM disorders : --3 diseases for RBMXL2 : About MalaCards male infertility infertility endometrial cancer 1 disease from the University of Copenhagen DISEASES database for RBMXL2 :Male infertility Export disorders for RBMXL2 gene to outside databases
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Publicationsfor RBMXL2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RBMXL2 gene, integrated from 9 sources (see all 21 ): (articles sorted by number of sources associating them with RBMXL2) Utopia : connect your pdf to the dynamic world of online information
An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene. (PubMed id 10958650) 1 , 2 , 3 Elliott D.J.... Cooke H.J. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Localization of the germ cell-specific protein, hnRNP G-T, in testicular biopsies of azoospermic men. (PubMed id 12389739) 1 , 9 Maymon B.B....Yavetz H. (2002) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Expression levels of hnRNP G and hTra2-beta1 correlat e with opposite outcomes in endometrial cancer biology. (PubMed id 20607830) 1 Ouyang Y.Q....Stickeler E. (2011) Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446) 1 Lopitz-Otsoa F....Rodriguez M.S. (2011) Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590) 1 Emanuele M.J....Elledge S.J. (2011) Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914) 1 Grant M.M. (2010) Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts. (PubMed id 21327109) 1 Kanhoush R....Penrad-Mobayed M. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010)
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External Searches for RBMXL2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RBMXL2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RBMXL2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RBMXL2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RBMXL2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RBMXL2 gene: Search GeneIP for patents involving RBMXL2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RBMXL2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBMXL2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RBMXL2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RBMXL2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RBMXL2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RBMXL2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RBMXL2
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RBMXL2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMXL2
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