RBMXL1 Gene
protein-coding GIFtS: 39
GCID: GC01M089446
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RNA binding motif protein, X-linked-like 1
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Aliases
for RBMXL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein, X-Linked-Like 11 2 | | Heterogeneous Nuclear Ribonucleoprotein G-Like 12 3 | | KAT31 | | RBM12 | | RNA Binding Motif Protein, X-Linked-Like-12 |
Export aliases for RBMXL1 gene to outside databasesPrevious GC identifers: GC01M089116 GC01M089218 GC00U930610 GC01M087562 |
Summaries
for RBMXL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBMXL1:
This gene represents a retrogene of RNA binding motif protein, X-linked (RBMX), which is located on chromosome X. Whileall introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there isspecific evidence for transcription at this location. The preservation of the ORF by purifying selection in all OldWorld monkeys carrying it suggests that this locus is likely to be functional, possibly during male meiosis when Xchromosomal genes are silenced or during haploid stages of spermatogenesis. This gene shares 5' exon structure withthe cysteine conjugate-beta lyase 2 locus on chromosome 1, but the coding sequences are non-overlapping. Alternativesplicing results in two transcript variants. (provided by RefSeq, Jun 2009)
UniProtKB/Swiss-Prot: RMXL1_HUMAN, Q96E39Function: RNA-binding protein which may be involved in pre-mRNA splicing (By similarity)
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Genomic Views
for RBMXL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RBMXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBMXL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBMXL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22.2 Ensembl cytogenetic band: 1p22.2 HGNC cytogenetic band: 1p22.2RBMXL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M089446: view genomic region
(about GC identifiers)
Start:
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89,445,139 bp from pter |
End:
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89,458,643 bp from pter |
Size:
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13,505 bases |
Orientation:
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minus strand |
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Proteins
for RBMXL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RMXL1_HUMAN, Q96E39 (See
protein sequence)Recommended Name: RNA binding motif protein, X-linked-like-1 Size: 390 amino acids; 42142 Da
Subcellular location: Nucleus (By similarity)
Miscellaneous: According to some authors, RBMXL1 is a RBMX retrogene on chromosome X which is likely to be functional(PubMed:16201836)
Caution: The first non-coding exon of RBMXL1 is in common with that of CCBL2Explore the universe of human proteins at neXtProt for RBMXL1: NX_Q96E39
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96E39
RBMXL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001156008.1 NP_062556.2
ENSEMBL proteins: ENSP00000318415 ENSP00000446099
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0030529 | ribonucleoprotein complex |
IEA | -- |
RBMXL1 for ontologies About GeneDecksing
RBMXL1 Antibody Products:
Assay Products for RBMXL1: |
Protein
Domains /
Families
for RBMXL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBMXL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96E39ProtoNet protein and cluster: Q96E39 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB012604 RBM1CTR
UniProtKB/Swiss-Prot: RMXL1_HUMAN, Q96E39Similarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for RBMXL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RMXL1_HUMAN, Q96E39Function: RNA-binding protein which may be involved in pre-mRNA splicing (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBMXL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBMXL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RBMXL1 (NM_019610) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBMXL1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBMXL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMXL1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- |
RBMXL1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RBMXL1:
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Pathways & Interactions
for RBMXL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for RBMXL1):
RBMXL1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBMXL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/18 Interacting proteins for RBMXL1 (Q96E393 ENSP000003184154) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
RBMXL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBMXL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBMXL1
Search CenterWatch for drugs/clinical trials and news about RBMXL1 / RMXL1
|
Transcripts
for RBMXL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBMXL1 gene (2 alternative transcripts): NM_001162536.2 NM_019610.5 3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321792 ENST00000413769 ENST00000399794(uc009wcx.3 uc001dms.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBMXL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBMXL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RBMXL1 (NM_019610) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBMXL1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBMXL1 |
GeneLoc Exon Structure
|
Expression
for RBMXL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBMXL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RBMXL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBMXL1
SABiosciences Custom PCR Arrays for RBMXL1
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RBMXL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBMXL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBMXL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMXL1 |
Orthologs
for RBMXL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBMXL1 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for RBMXL1 (if available)
TreeFam Gene Tree for RBMXL1 (if available) |
Paralogs
for RBMXL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBMXL1 gene
- RBMY1E2 RBMY1J2 RBMY1F2 RBMXL22 RBMXL32 TRA2B2 RBMY1B2 RBMY1A12
- CIRBP2 RBM32 TRA2A2 RBMX2 RBMY1D2
10 SIMAP similar genes for RBMXL1 using alignment to 1 protein entry: RMXL1_HUMAN:RBMX RBMXL2 RBMY1D RBMY1E RBMY1J RBMXL3
RBMY1A1 RBMY1B RBMY1C RBMY1F
RBMXL1 for paralogs About GeneDecksing
|
Genomic Variants
for RBMXL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RBMXL1
1 CNV: 3298
1 Indel: 59940 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBMXL1 |
|
Disorders
/ Diseases
for RBMXL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBMXL1 for disorders About GeneDecksing
2  diseases for RBMXL1: About MalaCardshuntington's disease schizophrenia
Export disorders for RBMXL1 gene to outside databases
|
Publications
for RBMXL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBMXL1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with RBMXL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)1 Martins-de-Souza D....Turck C.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Extensive gene traffic on the mammalian X chromosome. (PubMed id 14739461)1 Emerson J.J....Long M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for RBMXL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RBMXL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBMXL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBMXL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBMXL1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RBMXL1 gene:
Search GeneIP for patents involving RBMXL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBMXL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBMXL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBMXL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBMXL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBMXL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBMXL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBMXL1 |
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| | | | Search Tocris compounds for RBMXL1 |
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 | | | RBMXL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMXL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for RBMXL1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBMXL1 |
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