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Aliases for RBMXL1 Gene

Aliases for RBMXL1 Gene

  • RNA Binding Motif Protein, X-Linked Like 1 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein G-Like 1 3 4
  • RNA Binding Motif Protein, X-Linked-Like-1 3
  • Kynurenine Aminotransferase III 2
  • RBM1 3

External Ids for RBMXL1 Gene

Previous GeneCards Identifiers for RBMXL1 Gene

  • GC01M089116
  • GC01M089218
  • GC00U930610
  • GC01M089446
  • GC01M087562

Summaries for RBMXL1 Gene

Entrez Gene Summary for RBMXL1 Gene

  • This gene represents a retrogene of RNA binding motif protein, X-linked (RBMX), which is located on chromosome X. While all introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there is specific evidence for transcription at this location. The preservation of the ORF by purifying selection in all Old World monkeys carrying it suggests that this locus is likely to be functional, possibly during male meiosis when X chromosomal genes are silenced or during haploid stages of spermatogenesis. This gene shares 5' exon structure with the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the coding sequences are non-overlapping. Alternative splicing results in two transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for RBMXL1 Gene

RBMXL1 (RNA Binding Motif Protein, X-Linked Like 1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMX.

UniProtKB/Swiss-Prot for RBMXL1 Gene

  • RNA-binding protein which may be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMXL1 Gene

Genomics for RBMXL1 Gene

Regulatory Elements for RBMXL1 Gene

Enhancers for RBMXL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F088983 1.1 Ensembl ENCODE 10.6 +8.0 7985 3.0 PKNOX1 RAD21 RFX5 CHAMP1 RCOR1 HMG20B ZNF654 JUNB CEBPB REST GBP6 RBMXL1 GBP5 LOC100421401 KYAT3 GC01M088952
GH01F089051 0.2 ENCODE 4.6 -59.1 -59111 1.5 ZNF316 MAFG EMSY MAFK NR2F2 GBP3 GBP5 GBP7 RBMXL1 GC01M089045 GBP1
GH01F089043 0.8 ENCODE 4.6 -52.3 -52338 3.1 ELF3 MLX ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 RARA YY1 GATA4 GBP3 GBP5 GBP7 RBMXL1 GC01M089045 LOC105378841
GH01F088697 0.2 Ensembl 4.6 +294.8 294760 2.0 GATAD2A MTA2 HLF JUN JUND ATF3 IKZF1 SCRT2 FOS SPI1 RBMXL1 GC01P088703 PKN2-AS1
GH01F089081 0.8 Ensembl ENCODE 4.5 -88.3 -88341 0.6 PKNOX1 ZNF740 ZBTB11 GTF2E2 RELA TFDP1 ATF3 IKZF1 NFE2 ZNF584 GBP7 GBP3 GBP5 RBMXL1 GBP1 GC01M089104
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBMXL1 on UCSC Golden Path with GeneCards custom track

Promoters for RBMXL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078383 360 3201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FOS KLF13

Genomic Location for RBMXL1 Gene

Chromosome:
1
Start:
88,979,456 bp from pter
End:
88,992,960 bp from pter
Size:
13,505 bases
Orientation:
Minus strand

Genomic View for RBMXL1 Gene

Genes around RBMXL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMXL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMXL1 Gene

Proteins for RBMXL1 Gene

  • Protein details for RBMXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E39-RMXL1_HUMAN
    Recommended name:
    RNA binding motif protein, X-linked-like-1
    Protein Accession:
    Q96E39

    Protein attributes for RBMXL1 Gene

    Size:
    390 amino acids
    Molecular mass:
    42142 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to some authors, RBMXL1 is a RBMX retrogene on chromosome X which is likely to be functional.

neXtProt entry for RBMXL1 Gene

Post-translational modifications for RBMXL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMXL1 Gene

No data available for DME Specific Peptides for RBMXL1 Gene

Domains & Families for RBMXL1 Gene

Gene Families for RBMXL1 Gene

Suggested Antigen Peptide Sequences for RBMXL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96E39

UniProtKB/Swiss-Prot:

RMXL1_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBMXL1: view

Function for RBMXL1 Gene

Molecular function for RBMXL1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which may be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for RBMXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBMXL1: view
genes like me logo Genes that share phenotypes with RBMXL1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMXL1 Gene

Localization for RBMXL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMXL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMXL1 Gene COMPARTMENTS Subcellular localization image for RBMXL1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBMXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RBMXL1: view

Pathways & Interactions for RBMXL1 Gene

SuperPathways for RBMXL1 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RBMXL1: view

Pathways by source for RBMXL1 Gene

1 KEGG pathway for RBMXL1 Gene

Interacting Proteins for RBMXL1 Gene

Gene Ontology (GO) - Biological Process for RBMXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with RBMXL1: view

No data available for SIGNOR curated interactions for RBMXL1 Gene

Transcripts for RBMXL1 Gene

mRNA/cDNA for RBMXL1 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMXL1 Gene

No ASD Table

Relevant External Links for RBMXL1 Gene

GeneLoc Exon Structure for
RBMXL1
ECgene alternative splicing isoforms for
RBMXL1

Expression for RBMXL1 Gene

mRNA expression in normal human tissues for RBMXL1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBMXL1 Gene



Protein tissue co-expression partners for RBMXL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBMXL1 Gene:

RBMXL1
genes like me logo Genes that share expression patterns with RBMXL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBMXL1 Gene

Orthologs for RBMXL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMXL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBMX 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbmx 35
  • 94 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rbmxl1 34
  • 86.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RBMX 35
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 88 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rbmx 35
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tra2 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 35
  • 23 (a)
OneToMany
Species where no ortholog for RBMXL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMXL1 Gene

ENSEMBL:
Gene Tree for RBMXL1 (if available)
TreeFam:
Gene Tree for RBMXL1 (if available)

Paralogs for RBMXL1 Gene

(10) SIMAP similar genes for RBMXL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RBMXL1: view

Variants for RBMXL1 Gene

Sequence variations from dbSNP and Humsavar for RBMXL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1053196 -- 88,980,453(-) TAATA(A/C)AACTT intron-variant, utr-variant-3-prime
rs10638041 -- 88,991,983(+) TTTGG(-/T/TT/TTTT)TTTTT intron-variant
rs10754258 -- 88,982,295(+) TTTAG(A/T)TGGCT intron-variant, utr-variant-3-prime
rs10801700 -- 88,979,362(+) AAACT(A/G)TAAGA intron-variant, downstream-variant-500B
rs10922533 -- 88,990,976(+) AGTTT(C/G)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMXL1 Gene

Variant ID Type Subtype PubMed ID
dgv207n100 CNV loss 25217958
esv2758948 CNV gain 17122850
esv7403 CNV gain 19470904
nsv1002798 CNV gain 25217958
nsv946054 CNV duplication 23825009

Variation tolerance for RBMXL1 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBMXL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBMXL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMXL1 Gene

Disorders for RBMXL1 Gene

Relevant External Links for RBMXL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBMXL1

No disorders were found for RBMXL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMXL1 Gene

Publications for RBMXL1 Gene

  1. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3 4 64
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for RBMXL1 Gene

Sources for RBMXL1 Gene

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