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Aliases for RBMX2 Gene

Aliases for RBMX2 Gene

  • RNA Binding Motif Protein, X-Linked 2 2 3 5
  • RNA-Binding Motif Protein, X-Linked 2 3
  • CGI-79 3
  • Snu17 3

External Ids for RBMX2 Gene

Previous GeneCards Identifiers for RBMX2 Gene

  • GC0XP128242
  • GC0XP129261
  • GC0XP129363
  • GC0XP129535
  • GC0XP118931

Summaries for RBMX2 Gene

GeneCards Summary for RBMX2 Gene

RBMX2 (RNA Binding Motif Protein, X-Linked 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

Additional gene information for RBMX2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMX2 Gene

Genomics for RBMX2 Gene

Regulatory Elements for RBMX2 Gene

Enhancers for RBMX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH129952 1.1 Ensembl ENCODE 23.5 -449.0 -449021 1 ATF1 ARNT NFRKB CREM ZBTB2 USF2 REST ZNF589 MTA1 SMARCA4 ZNF280C RBMX2 BCORL1 UTP14A LOC105373335
GH0XH130117 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -282.1 -282102 4 ATF1 SIN3A ZNF2 ZBTB7B GLIS2 ZNF143 FOS ATF7 RUNX3 REST ZNF280C AIFM1 RAB33A ELF4 RBMX2 BCORL1 SASH3
GH0XH130170 1.3 FANTOM5 ENCODE 13.2 -229.3 -229272 4 PKNOX1 ATF1 SIN3A ZNF766 GATA2 ELK1 ATF7 RUNX3 ZNF592 MEF2D ZNF280C RBMX2 BCORL1 UTP14A ELF4 RAB33A GC0XP130201
GH0XH130108 1.2 ENCODE dbSUPER 10.4 -291.6 -291572 4 HDGF ATF1 ARNT SIN3A GLIS2 FOS ATF7 RUNX3 ZNF202 ZNF592 ZNF280C BCORL1 RBMX2 ELF4 AIFM1 GC0XP130039
GH0XH129981 1.1 ENCODE 10.8 -419.0 -418996 4 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 SP3 REST ZNF280C RBMX2 BCORL1 ELF4 PIR40748
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBMX2 on UCSC Golden Path with GeneCards custom track

Promoters for RBMX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248722 131 1801 HDAC1 TBP DMAP1 ZBTB40 ELK1 EGR1 SCRT2 ZNF207 ATF7 RUNX3

Genomic Location for RBMX2 Gene

Chromosome:
X
Start:
130,401,969 bp from pter
End:
130,413,343 bp from pter
Size:
11,375 bases
Orientation:
Plus strand

Genomic View for RBMX2 Gene

Genes around RBMX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMX2 Gene

Proteins for RBMX2 Gene

  • Protein details for RBMX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y388-RBMX2_HUMAN
    Recommended name:
    RNA-binding motif protein, X-linked 2
    Protein Accession:
    Q9Y388
    Secondary Accessions:
    • A8K9Z0
    • Q5JY82
    • Q9Y3I8

    Protein attributes for RBMX2 Gene

    Size:
    322 amino acids
    Molecular mass:
    37336 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBMX2 Gene

Post-translational modifications for RBMX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMX2 Gene

Domains & Families for RBMX2 Gene

Gene Families for RBMX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBMX2 Gene

Suggested Antigen Peptide Sequences for RBMX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y388

UniProtKB/Swiss-Prot:

RBMX2_HUMAN :
  • Belongs to the IST3 family.
Family:
  • Belongs to the IST3 family.
genes like me logo Genes that share domains with RBMX2: view

Function for RBMX2 Gene

Gene Ontology (GO) - Molecular Function for RBMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000384 contributes_to first spliceosomal transesterification activity IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with RBMX2: view
genes like me logo Genes that share phenotypes with RBMX2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBMX2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBMX2 Gene

Localization for RBMX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBMX2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005686 U2 snRNP IBA --
GO:0070274 RES complex IBA --
GO:0071011 precatalytic spliceosome IBA --
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with RBMX2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RBMX2 Gene

Pathways & Interactions for RBMX2 Gene

SuperPathways for RBMX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBMX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006406 mRNA export from nucleus IBA --
genes like me logo Genes that share ontologies with RBMX2: view

No data available for Pathways by source and SIGNOR curated interactions for RBMX2 Gene

Drugs & Compounds for RBMX2 Gene

No Compound Related Data Available

Transcripts for RBMX2 Gene

Unigene Clusters for RBMX2 Gene

RNA binding motif protein, X-linked 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBMX2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RBMX2 Gene

No ASD Table

Relevant External Links for RBMX2 Gene

GeneLoc Exon Structure for
RBMX2
ECgene alternative splicing isoforms for
RBMX2

Expression for RBMX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBMX2 Gene

Protein differential expression in normal tissues from HIPED for RBMX2 Gene

This gene is overexpressed in Adrenal (25.3), Peripheral blood mononuclear cells (22.7), and Lung (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBMX2 Gene



Protein tissue co-expression partners for RBMX2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBMX2 Gene:

RBMX2

SOURCE GeneReport for Unigene cluster for RBMX2 Gene:

Hs.740515

Evidence on tissue expression from TISSUES for RBMX2 Gene

  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RBMX2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMX2 Gene

Orthologs for RBMX2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBMX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBMX2 33 34
  • 98.03 (n)
cow
(Bos Taurus)
Mammalia RBMX2 33 34
  • 85.02 (n)
-- 34
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RBMX2 33 34
  • 83.23 (n)
rat
(Rattus norvegicus)
Mammalia Rbmx2 33
  • 81.12 (n)
mouse
(Mus musculus)
Mammalia Rbmx2 33 16 34
  • 78.97 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RBMX2 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBMX2 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBMX2 34
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64376 33
zebrafish
(Danio rerio)
Actinopterygii rbmx2 34
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10466 33 34
  • 64.96 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000977 33
  • 64.23 (n)
worm
(Caenorhabditis elegans)
Secernentea C30B5.4 34
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST3 34
  • 44 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.7367 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2920 34
  • 31 (a)
OneToOne
Species where no ortholog for RBMX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMX2 Gene

ENSEMBL:
Gene Tree for RBMX2 (if available)
TreeFam:
Gene Tree for RBMX2 (if available)

Paralogs for RBMX2 Gene

(3) SIMAP similar genes for RBMX2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBMX2: view

No data available for Paralogs for RBMX2 Gene

Variants for RBMX2 Gene

Sequence variations from dbSNP and Humsavar for RBMX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5977266 Benign 130,412,739(+) AGGGC(A/G)TAGTT reference, missense
rs1000110556 -- 130,401,911(+) CCGGT(A/G)CGCCC upstream-variant-2KB
rs1000235346 -- 130,402,120(+) TCTGC(A/G)GGGCC intron-variant
rs1000336226 -- 130,401,590(+) TGCCA(C/T)GACAG upstream-variant-2KB
rs1000494652 -- 130,413,490(+) ATTGC(C/T)TCTGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RBMX2 Gene

Variant ID Type Subtype PubMed ID
esv2017730 CNV deletion 18987734
esv2440853 CNV deletion 19546169
esv2740470 CNV deletion 23290073
esv3559329 CNV deletion 23714750
esv3574567 CNV loss 25503493
nsv528290 CNV gain 19592680

Variation tolerance for RBMX2 Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBMX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBMX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMX2 Gene

Disorders for RBMX2 Gene

Relevant External Links for RBMX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBMX2

No disorders were found for RBMX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMX2 Gene

Publications for RBMX2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for RBMX2 Gene

Sources for RBMX2 Gene

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