Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBMX Gene

Aliases for RBMX Gene

  • RNA Binding Motif Protein, X-Linked 2 3
  • Heterogeneous Nuclear Ribonucleoprotein G 2 3 4
  • RNA Binding Motif Protein, X Chromosome 2 3
  • Glycoprotein P43 3 4
  • HnRNP G 3 4
  • RBMXP1 3 4
  • HNRPG 3 4
  • RNA-Binding Motif Protein, X Chromosome 3
  • HnRNP-G 3
  • HNRNPG 3
  • RBMXRT 3
  • RNMX 3

External Ids for RBMX Gene

Summaries for RBMX Gene

Entrez Gene Summary for RBMX Gene

  • This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009]

GeneCards Summary for RBMX Gene

RBMX (RNA Binding Motif Protein, X-Linked) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBMXL1.

UniProtKB/Swiss-Prot for RBMX Gene

  • RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.

Gene Wiki entry for RBMX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMX Gene

Genomics for RBMX Gene

Genomic Location for RBMX Gene

Start:
136,848,004 bp from pter
End:
136,880,780 bp from pter
Size:
32,777 bases
Orientation:
Minus strand

Genomic View for RBMX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBMX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMX Gene

Regulatory Elements for RBMX Gene

Proteins for RBMX Gene

  • Protein details for RBMX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38159-RBMX_HUMAN
    Recommended name:
    RNA-binding motif protein, X chromosome
    Protein Accession:
    P38159
    Secondary Accessions:
    • B4E3U4
    • D3DWH0
    • E9PG86
    • Q5JQ67
    • Q8N8Y7
    • Q969R3

    Protein attributes for RBMX Gene

    Size:
    391 amino acids
    Molecular mass:
    42332 Da
    Quaternary structure:
    • Homomultimer. Interacts with SAFB/SAFB1 (By similarity). Found in the supraspliceosome complex. Identified in the spliceosome C complex. Interacts with KHDRBS3. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA. Interacts with CLK2, KHDRBS2, SAFB, TRA2B and YTHDC1. Interacts with ERAP1; the interaction is RNA-independent.

    Three dimensional structures from OCA and Proteopedia for RBMX Gene

    Alternative splice isoforms for RBMX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBMX Gene

Proteomics data for RBMX Gene at MOPED

Post-translational modifications for RBMX Gene

  • Arg-185 is dimethylated, probably to asymmetric dimethylarginine
  • Cleavage of initiator Met is partial. If Met-1 is not removed, it is acetylated. If it is removed, Val-2 is acetylated.
  • O-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9, Lys22, Lys30, Lys63, and Lys217

Other Protein References for RBMX Gene

No data available for DME Specific Peptides for RBMX Gene

Domains for RBMX Gene

Gene Families for RBMX Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

RBMX_HUMAN
Domain:
  • The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA.:
    • P38159
  • Contains 1 RRM (RNA recognition motif) domain.:
    • P38159
genes like me logo Genes that share domains with RBMX: view

Function for RBMX Gene

Molecular function for RBMX Gene

GENATLAS Biochemistry: heterogeneous nuclear RNA ribonucleoprotein complex,core protein G (p43),RBMY paralog on chromosome X,previously mapped to chromosome 6 (see RBMXP1)
UniProtKB/Swiss-Prot Function: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.

Gene Ontology (GO) - Molecular Function for RBMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001047 core promoter binding IDA 18541147
GO:0003676 nucleic acid binding --
GO:0003682 chromatin binding IDA 18541147
GO:0003723 RNA binding NAS 7692398
genes like me logo Genes that share ontologies with RBMX: view

Phenotypes for RBMX Gene

MGI mutant phenotypes for RBMX:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RBMX: view

miRNA for RBMX Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBMX Gene

Localization for RBMX Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMX Gene

Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMX Gene COMPARTMENTS Subcellular localization image for RBMX gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus IDA 19282290
GO:0005654 nucleoplasm TAS --
GO:0005719 nuclear euchromatin IDA 21327109
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with RBMX: view

Pathways for RBMX Gene

genes like me logo Genes that share pathways with RBMX: view

Pathways by source for RBMX Gene

1 KEGG pathway for RBMX Gene

Gene Ontology (GO) - Biological Process for RBMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 12165565
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006366 transcription from RNA polymerase II promoter IDA 21327109
GO:0006376 mRNA splice site selection IEA --
genes like me logo Genes that share ontologies with RBMX: view

Transcripts for RBMX Gene

Unigene Clusters for RBMX Gene

RNA binding motif protein, X-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBMX Gene

No ASD Table

Relevant External Links for RBMX Gene

GeneLoc Exon Structure for
RBMX
ECgene alternative splicing isoforms for
RBMX

Expression for RBMX Gene

mRNA expression in normal human tissues for RBMX Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBMX Gene

SOURCE GeneReport for Unigene cluster for RBMX Gene Hs.380118

mRNA Expression by UniProt/SwissProt for RBMX Gene

P38159-RBMX_HUMAN
Tissue specificity: Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level).
genes like me logo Genes that share expressions with RBMX: view

Orthologs for RBMX Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 60 (a)
ManyToMany
RBMX 36
  • 99.74 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RBMX 36
  • 95.91 (n)
  • 99.74 (a)
dog
(Canis familiaris)
Mammalia RBMX 36
  • 96.68 (n)
  • 100 (a)
RBMX 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbmx 36
  • 93.35 (n)
  • 98.72 (a)
Rbmx 16
Rbmxl1 37
  • 98 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rbmx 36
  • 93.64 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves RBMX 36
  • 81.45 (n)
  • 90.4 (a)
RBMX 37
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 92 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.25221 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rbmx 36
  • 77.22 (n)
  • 84.16 (a)
Str.17070 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8906 36
zebrafish
(Danio rerio)
Actinopterygii rbmx 36
  • 67.06 (n)
  • 72.86 (a)
rbmx 37
  • 75 (a)
OneToMany
wufb37c07 36
fruit fly
(Drosophila melanogaster)
Insecta tra2 37
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 37
  • 24 (a)
OneToMany
Species with no ortholog for RBMX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBMX Gene

ENSEMBL:
Gene Tree for RBMX (if available)
TreeFam:
Gene Tree for RBMX (if available)

Paralogs for RBMX Gene

Paralogs for RBMX Gene

genes like me logo Genes that share paralogs with RBMX: view

Variants for RBMX Gene

Sequence variations from dbSNP and Humsavar for RBMX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1053044 -- 136,869,587(-) TTTTT(A/G)CACTC utr-variant-3-prime
rs1053053 -- 136,869,565(-) TAGCC(C/G)AATCT utr-variant-3-prime
rs1053065 -- 136,869,560(-) CAATC(C/T)TTCTA utr-variant-3-prime
rs1053069 -- 136,869,556(-) CTTTC(C/T)ATACT utr-variant-3-prime
rs1053075 -- 136,869,552(-) CTATA(C/T)TCTTA utr-variant-3-prime

Relevant External Links for RBMX Gene

HapMap Linkage Disequilibrium report
RBMX
Locus Specific Mutation Databases (LSDB)
RBMX

No data available for Structural Variations from Database of Genomic Variants (DGV) for RBMX Gene

Disorders for RBMX Gene

(1) Novoseek inferred disease relationships for RBMX Gene

Disease -log(P) Hits PubMed IDs
mental retardation 53.2 2

Relevant External Links for RBMX

Genetic Association Database (GAD)
RBMX
Human Genome Epidemiology (HuGE) Navigator
RBMX
genes like me logo Genes that share disorders with RBMX: view

No data available for UniProtKB/Swiss-Prot for RBMX Gene

Publications for RBMX Gene

  1. hnRNP G: sequence and characterization of a glycosylated RNA-binding protein. (PMID: 7692398) Soulard M. … Larsen C.-J. (Nucleic Acids Res. 1993) 3 4 23
  2. Expression and conservation of processed copies of the RBMX gene. (PMID: 11420617) Lingenfelter P.A. … Disteche C.M. (Mamm. Genome 2001) 3 4 23
  3. HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding. (PMID: 12761049) Nasim M.T. … Eperon I.C. (Hum. Mol. Genet. 2003) 3 4 23
  4. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. (PMID: 19282290) Heinrich B. … Stamm S. (J. Biol. Chem. 2009) 3 4 23
  5. T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA- binding protein implicated in spermatogenesis. (PMID: 10332027) Venables J.P. … Eperon I.C. (Hum. Mol. Genet. 1999) 3 4

Products for RBMX Gene

Sources for RBMX Gene

Back to Top

Content