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RBMX Gene

protein-coding   GIFtS: 57
GCID: GC0XM135951

RNA Binding Motif Protein, X-Linked

(Previous names: RNA binding motif protein, X chromosome)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RNA Binding Motif Protein, X-Linked1 2     HnRNP G2 3
Heterogeneous Nuclear Ribonucleoprotein G1 2 3     HNRNPG2
RNA Binding Motif Protein, X Chromosome1 2     RBMXRT2
Glycoprotein P432 3     RNMX2
HNRPG2 3     hnRNP-G2
RBMXP12 3     RNA-Binding Motif Protein, X Chromosome2

External Ids:    HGNC: 99101   Entrez Gene: 273162   Ensembl: ENSG000001472747   OMIM: 3001995   UniProtKB: P381593   
ORGUL members:         

Export aliases for RBMX gene to outside databases

Previous GC identifers: GC0XM130523 GC0XM132801 GC0XM133874 GC0XM134661 GC0XM135681 GC0XM135783 GC0XM125221


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBMX Gene:
This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene,
an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a
male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6,
were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants
encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns.
(provided by RefSeq, Sep 2009)

GeneCards Summary for RBMX Gene:
RBMX (RNA binding motif protein, X-linked) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBMY1J.

UniProtKB/Swiss-Prot: RBMX_HUMAN, P38159
Function: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional
processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several
pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be
involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1
promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome
complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon
inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses
the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs
localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to
pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated
inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the
extracellular compartment

Gene Wiki entry for RBMX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBMX gene promoter:
         POU3F1   CUTL1   POU6F1 (c2)   Nkx2-5   Evi-1   AREB6   MZF-1   CP2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBMX promoter sequence
   Search Chromatin IP Primers for RBMX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBMX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26

RBMX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBMX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM135951:  view genomic region     (about GC identifiers)

Start:
135,930,163 bp from pter      End:
135,962,939 bp from pter
Size:
32,777 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RBMX_HUMAN, P38159 (See protein sequence)
Recommended Name: RNA-binding motif protein, X chromosome  
Size: 391 amino acids; 42332 Da
Subunit: Homomultimer. Interacts with SAFB/SAFB1 (By similarity). Found in the supraspliceosome complex.
Identified in the spliceosome C complex. Interacts with KHDRBS3. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1,
NCOA5 and PPP1CA. Interacts with CLK2, KHDRBS2, SAFB, TRA2B and YTHDC1. Interacts with ERAP1; the interaction is
RNA-independent
Secondary accessions: B4E3U4 D3DWH0 E9PG86 Q5JQ67 Q8N8Y7 Q969R3
Alternative splicing: 3 isoforms:  P38159-1   P38159-2   P38159-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBMX: NX_P38159

Explore proteomics data for RBMX at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Arg-185 is dimethylated, probably to asymmetric dimethylarginine1
  • Cleavage of initiator Met is partial. If Met-1 is not removed, it is acetylated. If it is removed, Val-2 is
    acetylated1
  • Ubiquitination2 at Lys9, Lys22, Lys30, Lys63, Lys217
  • Modification sites at PhosphoSitePlus

  • See RBMX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158275.1  NP_002130.2  

    ENSEMBL proteins: 
     ENSP00000411989   ENSP00000457691   ENSP00000405117   ENSP00000456048   ENSP00000359645  
     ENSP00000457051   ENSP00000457866   ENSP00000454777   ENSP00000454674  
    Reactome Protein details: P38159

    RBMX Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RBMX

     
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    antibodies-online antibodies for RBMX (27 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012604 RBM1CTR
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P38159

    ProtoNet protein and cluster: P38159

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB012604 RBM1CTR


    UniProtKB/Swiss-Prot: RBMX_HUMAN, P38159
    Domain: The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its
    splicing activity does not require direct binding to RNA (By similarity)
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with RBMX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBMX_HUMAN, P38159
    Function: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional
    processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several
    pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be
    involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1
    promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome
    complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon
    inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses
    the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs
    localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to
    pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated
    inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the
    extracellular compartment

         Genatlas biochemistry entry for RBMX:
    heterogeneous nuclear RNA ribonucleoprotein complex,core protein G (p43),RBMY paralog on chromosome X,previously
    mapped to chromosome 6 (see RBMXP1)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0001047core promoter binding IDA18541147
    GO:0003676nucleic acid binding ----
    GO:0003682chromatin binding IDA18541147
    GO:0003723RNA binding NAS7692398
         
    Find genes that share ontologies with RBMX           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Rbmx):
     growth/size/body 

    Find genes that share phenotypes with RBMX           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RBMX

    miRNA
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    miRTarBase miRNAs that target RBMX:
    hsa-mir-181b-5p (MIRT047229), hsa-mir-196a-5p (MIRT048174), hsa-mir-126-3p (MIRT045695)

    Block miRNA regulation of human, mouse, rat RBMX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBMX (see all 11):
    hsa-miR-522 hsa-miR-1301 hsa-miR-548s hsa-miR-133b hsa-miR-3190 hsa-miR-20b* hsa-miR-224* hsa-miR-3926
    SwitchGear 3'UTR luciferase reporter plasmidRBMX 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBMX_HUMAN, P38159: Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the
    nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA19282290
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex ----
    GO:0005719nuclear euchromatin IDA--

    Find genes that share ontologies with RBMX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RBMX About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with RBMX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RBMX
        mRNA processing

    2 Reactome Pathways for RBMX
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


    1 Kegg Pathway  (Kegg details for RBMX):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBMX
    Interactions:

        GeneGlobe Interaction Network for RBMX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBMX (P381591, 2, 3 ENSP000003596454) via UniProtKB, MINT, STRING, and/or I2D (see all 830)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPKP619781, 2, 3, ENSP000003654394EBI-743526,EBI-304185 MINT-7945693 MINT-8338652 MINT-7947479 I2D: score=5 STRING: ENSP00000365439
    SF3A2Q154282, 3, ENSP000002214944MINT-5205845 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    TRA2BP629952, 3, ENSP000004169594MINT-8338575 I2D: score=3 STRING: ENSP00000416959
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA12165565
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter IDA--
    GO:0006376mRNA splice site selection IEA--
    GO:0006509membrane protein ectodomain proteolysis IDA18445477

    Find genes that share ontologies with RBMX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBMX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RBMX gene (2 alternative transcripts): 
    NM_001164803.1  NM_002139.3  

    Unigene Cluster for RBMX:

    RNA binding motif protein, X-linked
    Hs.380118  [show with all ESTs]
    Unigene Representative Sequence: BX647131
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561733 ENST00000431446(uc011mwf.1) ENST00000496459 ENST00000568578(uc004fad.1)
    ENST00000419968 ENST00000464781 ENST00000320676(uc011mwg.2 uc004fae.2)
    ENST00000562646 ENST00000565438 ENST00000567262 ENST00000563370 ENST00000565907
    ENST00000570135(uc004faf.2)
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    Additional mRNA sequence: 

    AK091520.1 AK096015.1 AK097941.1 AK304573.1 AK304868.1 AK309911.1 AY464692.1 BC006550.2 
    BC007435.2 BX647131.1 NR_028476.1 NR_028477.1 Z23064.1 Z69915.1 

    Selected DOTS entries (see all 59):

    DT.453763  DT.87016183  DT.40226666  DT.87016185  DT.91729054  DT.100891007  DT.100045391  DT.100890956 
    DT.97865264  DT.95352904  DT.91902258  DT.99952075  DT.95352955  DT.100890906  DT.100045392  DT.100890982 
    DT.100829954  DT.121322155  DT.65287485  DT.100890961  DT.97760281  DT.100890957  DT.100890975  DT.97800495 

    Selected AceView cDNA sequences (see all 955):

    CB117987 BU944616 CD364897 BQ428252 BU734845 AU107501 AU107525 BU182207 
    AI741778 CF242995 CA312969 BM908512 BQ220508 BU839047 CR607658 BF445934 
    BM746148 AI148085 CB111769 CD743099 BQ882403 BG260282 AW075843 AU107488 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBMX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTATGTAAG
    RBMX Expression
    About this image

    RBMX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBMX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380118

    UniProtKB/Swiss-Prot: RBMX_HUMAN, P38159
    Tissue specificity: Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell
    carcinomas (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RBMX gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbmx1 , 5 RNA binding motif protein, X chromosome1, 5 93.35(n)1
    98.72(a)1
      X (31.64 cM)5
    196551  NM_001166623.11  NP_001160095.11 
     573835305 
    chicken
    (Gallus gallus)
    Aves RBMX1 RNA binding motif protein, X-linked 81.45(n)
    90.4(a)
      422248  NM_001079728.1  NP_001073196.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    92(a)
    1 → many
    GL343562.1(327293-337930)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252212 Xenopus laevis transcribed sequence with weak similarity more 79.28(n)    CA790306.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb37c072 Danio rerio cDNA clone MGC56625 IMAGE5915688, complete more 74.93(n)    BC049509.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tra26
    transformer 2
    20(a)
    1 → many
    2R(10489509-10491857)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-86
    Protein RSP-8, isoform a
    24(a)
    1 → many
    III(11826215-11831475) WBGene00004705


    ENSEMBL Gene Tree for RBMX (if available)
    TreeFam Gene Tree for RBMX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBMX gene
    RBMY1J2  RBMY1E2  RBMY1F2  TRA2B2  RBMXL22  RBMXL32  RBMY1B2  RBMXL12  
    RBMY1A12  CIRBP2  RBM32  TRA2A2  RBMY1D2  
    Selected SIMAP similar genes for RBMX using alignment to 7 protein entries:     RBMX_HUMAN (see all proteins) (see all similar genes):
    RBMXL1    DAZAP1    RBMXL2    RBM    MSI2    BOLL
    CIRBP    RBMY1A1    DAZ4    RBM42    RBM3    SRSF2
    RBMY1D    RBMY1E    ELAVL2    RBFOX1    CELF2    HNRNPA1

    Find genes that share paralogs with RBMX           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for RBMX
    PGOHUM00000242821 PGOHUM00000239546 PGOHUM00000245652 PGOHUM00000243181 PGOHUM00000236424


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBMX (see all 310)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808844501,2
    --135909457(+) AACTAA/GTCAGA 1 -- ds50010--------
    rs1850513581,2
    --135909760(+) GCCTAA/GTCACA 1 -- ds50010--------
    rs120110301,2
    C,H--135909895(+) CTAAGT/CAAAGA 1 -- ds50012Minor allele frequency- C:0.00NA 4
    rs1384019441,2
    --135909969(+) TCCAAA/GAAGTG 1 -- ut310--------
    rs10531701,2
    --135910039(-) TGATAC/TAGAAA 1 -- ut313Minor allele frequency- T:0.49MN NA 188
    rs1916200111,2
    --135910075(+) CAGAAA/GAATCA 1 -- ut310--------
    rs10531631,2
    --135910092(-) GAAAAG/AGAATC 1 -- ut312Minor allele frequency- A:0.00MN NA 186
    rs10531611,2
    --135910103(-) GCAGAT/CGTGTG 1 -- ut313Minor allele frequency- C:0.00MN NA 188
    rs10531581,2
    --135910112(-) ACTGAC/ACTAGC 1 -- ut312Minor allele frequency- A:0.00NA 4
    rs10531501,2
    --135910134(-) CCAGAT/CACCTG 1 -- ut313Minor allele frequency- C:0.00MN NA 188

    HapMap Linkage Disequilibrium report for RBMX (135930163 - 135962939 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RBMX: --
    Locus Specific Mutation Databases (LSDB): RBMX

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBMX
    DNA2.0 Custom Variant and Variant Library Synthesis for RBMX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300199    OMIM disorders: --


    Find genes that share disorders with RBMX           About GenesLikeMe

    1 Novoseek inferred disease relationship for RBMX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mental retardation 53.2 3 11944923 (1), 15548614 (1)

    Genetic Association Database (GAD): RBMX
    Human Genome Epidemiology (HuGE) Navigator: RBMX (1 document)

    Export disorders for RBMX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBMX gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with RBMX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. (PubMed id 19282290)1, 2, 9 Heinrich B.... Stamm S. (J. Biol. Chem. 2009)
    2. HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding. (PubMed id 12761049)1, 2, 9 Nasim M.T.... Eperon I.C. (Hum. Mol. Genet. 2003)
    3. Expression and conservation of processed copies of the RBMX gene. (PubMed id 11420617)1, 2, 9 Lingenfelter P.A.... Disteche C.M. (Mamm. Genome 2001)
    4. hnRNP G: sequence and characterization of a glycosylated RNA-binding protein. (PubMed id 7692398)1, 2, 9 Soulard M....Larsen C.-J. (Nucleic Acids Res. 1993)
    5. An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release. (PubMed id 18445477)1, 2 Adamik B.... Levine S.J. (Biochem. Biophys. Res. Commun. 2008)
    6. hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip. (PubMed id 18541147)1, 2 Shin K.H.... Park N.H. (Biochem. Biophys. Res. Commun. 2008)
    7. Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia. (PubMed id 16491274)1, 4 Tsujimura A....Okuyama A. (Asian J. Androl. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27316 HGNC: 9910 AceView: RBMX Ensembl:ENSG00000147274 euGenes: HUgn27316
    ECgene: RBMX Kegg: 27316 H-InvDB: RBMX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RBMX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBMX gene:
    Search GeneIP for patents involving RBMX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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