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Aliases for RBMS3 Gene

Aliases for RBMS3 Gene

  • RNA Binding Motif Single Stranded Interacting Protein 3 2 3 5
  • RNA Binding Motif, Single Stranded Interacting Protein 3 2
  • RNA Binding Motif, Single Stranded Interacting Protein 2
  • RNA-Binding Protein 2

External Ids for RBMS3 Gene

Previous GeneCards Identifiers for RBMS3 Gene

  • GC03P028763
  • GC03P029172
  • GC03P029297
  • GC03P029298
  • GC03P028880

Summaries for RBMS3 Gene

Entrez Gene Summary for RBMS3 Gene

  • This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

GeneCards Summary for RBMS3 Gene

RBMS3 (RNA Binding Motif Single Stranded Interacting Protein 3) is a Protein Coding gene. Diseases associated with RBMS3 include Osteonecrosis Of The Jaw. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMS1.

UniProtKB/Swiss-Prot for RBMS3 Gene

  • Binds poly(A) and poly(U) oligoribonucleotides.

Additional gene information for RBMS3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMS3 Gene

Genomics for RBMS3 Gene

Regulatory Elements for RBMS3 Gene

Enhancers for RBMS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H029331 1.3 Ensembl ENCODE dbSUPER 10.6 +759.3 759260 5.9 TBP SIN3A RAD21 RELA ZNF366 POLR2A SCRT2 SMC3 ZNF600 PRDM10 RBMS3 GC03M029337 RBMS3-AS3
GH03H029323 1.2 Ensembl ENCODE dbSUPER 11.3 +749.7 749665 1.8 HDGF PKNOX1 JUN ZSCAN4 MAX ATF7 ETV6 RUNX3 IKZF2 USF2 RBMS3 RBMS3-AS3 GC03M029337
GH03H029524 1.2 Ensembl ENCODE dbSUPER 10.5 +950.6 950619 1.7 FOXA2 MAX REST NR3C1 RAD21 FOXA1 NR2F2 GABPA YY1 JUND RBMS3 GC03M029571 GC03P029390
GH03H029184 1 Ensembl ENCODE 9.7 +611.9 611873 4.2 PKNOX1 JUN HIC1 ZNF366 POLR2A ATF7 FOS KLF8 ZNF639 SP3 RBMS3 GC03P029245 GC03P029087
GH03H029440 0.8 Ensembl ENCODE 10.4 +866.1 866071 0.9 PKNOX1 POLR2A ZNF341 ZNF133 PRDM1 TRIM28 RBMS3 RBMS3-AS2 GC03P029390 GC03M029571
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBMS3 on UCSC Golden Path with GeneCards custom track

Promoters for RBMS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150066 1109 1001 CTCF MXI1 ZSCAN4 ZNF133 BRCA1 HIC1 GLIS2 POLR2A PATZ1 ZNF600

Genomic Locations for RBMS3 Gene

Genomic Locations for RBMS3 Gene
1,435,605 bases
Plus strand

Genomic View for RBMS3 Gene

Genes around RBMS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMS3 Gene

Proteins for RBMS3 Gene

  • Protein details for RBMS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding motif, single-stranded-interacting protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K9S4
    • B7ZL17
    • G5E9J9
    • O75876
    • Q17RI0
    • Q6XE23

    Protein attributes for RBMS3 Gene

    437 amino acids
    Molecular mass:
    47840 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC63910.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305};

    Alternative splice isoforms for RBMS3 Gene


neXtProt entry for RBMS3 Gene

Post-translational modifications for RBMS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBMS3 Gene

Domains & Families for RBMS3 Gene

Gene Families for RBMS3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBMS3 Gene

Suggested Antigen Peptide Sequences for RBMS3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBMS3: view

No data available for UniProtKB/Swiss-Prot for RBMS3 Gene

Function for RBMS3 Gene

Molecular function for RBMS3 Gene

UniProtKB/Swiss-Prot Function:
Binds poly(A) and poly(U) oligoribonucleotides.

Phenotypes From GWAS Catalog for RBMS3 Gene

Gene Ontology (GO) - Molecular Function for RBMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003730 mRNA 3-UTR binding IEA --
GO:0008143 poly(A) binding IDA 10675610
GO:0008266 poly(U) RNA binding IDA 10675610
GO:0035925 mRNA 3-UTR AU-rich region binding IDA 10675610
genes like me logo Genes that share ontologies with RBMS3: view
genes like me logo Genes that share phenotypes with RBMS3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMS3 Gene

Localization for RBMS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMS3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBMS3 gene
Compartment Confidence
nucleus 3
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RBMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 10675610
genes like me logo Genes that share ontologies with RBMS3: view

Pathways & Interactions for RBMS3 Gene

SuperPathways for RBMS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002357 defense response to tumor cell IMP 28409548
GO:0010628 positive regulation of gene expression IMP 28409548
GO:0010629 negative regulation of gene expression IMP 28409548
GO:0045727 positive regulation of translation IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IMP 28409548
genes like me logo Genes that share ontologies with RBMS3: view

No data available for Pathways by source and SIGNOR curated interactions for RBMS3 Gene

Drugs & Compounds for RBMS3 Gene

(1) Drugs for RBMS3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bisphosphonates Pharma 0
genes like me logo Genes that share compounds with RBMS3: view

Transcripts for RBMS3 Gene

Unigene Clusters for RBMS3 Gene

RNA binding motif, single stranded interacting protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMS3 Gene

No ASD Table

Relevant External Links for RBMS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBMS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBMS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBMS3 Gene

This gene is overexpressed in Fetal testis (18.8), Gallbladder (15.4), Pancreas (9.2), Placenta (9.2), Fetal ovary (7.4), and Fetal heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBMS3 Gene

Protein tissue co-expression partners for RBMS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBMS3 Gene:


SOURCE GeneReport for Unigene cluster for RBMS3 Gene:


mRNA Expression by UniProt/SwissProt for RBMS3 Gene:

Tissue specificity: Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with RBMS3: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMS3 Gene

Orthologs for RBMS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBMS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBMS3 33 34
  • 99.85 (n)
(Canis familiaris)
Mammalia RBMS3 33 34
  • 97.56 (n)
(Bos Taurus)
Mammalia RBMS3 33 34
  • 95.34 (n)
(Ornithorhynchus anatinus)
Mammalia RBMS3 34
  • 94 (a)
(Rattus norvegicus)
Mammalia Rbms3 33
  • 91.03 (n)
(Mus musculus)
Mammalia Rbms3 33 16 34
  • 90.87 (n)
(Monodelphis domestica)
Mammalia RBMS3 34
  • 87 (a)
(Gallus gallus)
Aves RBMS3 33 34
  • 91.17 (n)
(Anolis carolinensis)
Reptilia RBMS3 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbms3 33
  • 84.09 (n)
(Danio rerio)
Actinopterygii rbms3 33 34
  • 79.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta shep 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea R10E4.2b 35
  • 58 (a)
R10E4.2a 35
  • 51 (a)
sup-26 34
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1122 34
  • 44 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3614 33
Species where no ortholog for RBMS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBMS3 Gene

Gene Tree for RBMS3 (if available)
Gene Tree for RBMS3 (if available)

Paralogs for RBMS3 Gene

(4) SIMAP similar genes for RBMS3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBMS3: view

Variants for RBMS3 Gene

Sequence variations from dbSNP and Humsavar for RBMS3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000010051 -- 29,692,277(+) GCGCC(C/T)GACCT intron-variant
rs1000019323 -- 29,653,943(+) TAAAC(A/C)TTGTC intron-variant
rs1000020865 -- 29,450,665(+) TTGAA(A/T)GCCTT intron-variant
rs1000026058 -- 29,664,579(+) AGATA(G/T)CCAGT intron-variant
rs1000026546 -- 29,826,038(+) TGAAA(A/G)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMS3 Gene

Variant ID Type Subtype PubMed ID
nsv954456 CNV duplication 24416366
nsv834650 CNV gain 17160897
nsv818133 CNV loss 17921354
nsv590026 CNV gain 21841781
nsv527860 CNV loss 19592680
nsv521764 CNV loss 19592680
nsv518057 CNV loss 19592680
nsv1131688 CNV deletion 24896259
nsv1116979 CNV deletion 24896259
nsv10257 CNV loss 18304495
nsv1010530 CNV gain 25217958
esv989202 CNV insertion 20482838
esv8206 CNV gain 19470904
esv3696 CNV loss 18987735
esv3595725 CNV loss 21293372
esv3595724 CNV loss 21293372
esv3595723 CNV loss 21293372
esv3595722 CNV loss 21293372
esv3595720 CNV loss 21293372
esv3595719 CNV loss 21293372
esv3595718 CNV loss 21293372
esv3595716 CNV loss 21293372
esv3595714 CNV loss 21293372
esv3595713 CNV loss 21293372
esv3595712 CNV loss 21293372
esv3595711 CNV gain 21293372
esv3595710 CNV loss 21293372
esv3595709 CNV loss 21293372
esv3568673 CNV loss 25503493
esv3568672 CNV loss 25503493
esv3568671 CNV loss 25503493
esv3561668 CNV deletion 23714750
esv3561667 CNV deletion 23714750
esv29311 CNV loss 19812545
esv2763248 CNV loss 21179565
esv2763246 CNV loss 21179565
esv2763245 CNV loss 21179565
esv2762326 CNV loss 21179565
esv2759137 CNV loss 17122850
esv275093 CNV loss 21479260
esv2725083 CNV deletion 23290073
esv2725082 CNV deletion 23290073
esv2725081 CNV deletion 23290073
esv2725080 CNV deletion 23290073
esv2725079 CNV deletion 23290073
esv2725078 CNV deletion 23290073
esv2678131 CNV deletion 23128226
esv2668775 CNV deletion 23128226
esv2663180 CNV deletion 23128226
esv2659346 CNV deletion 23128226
esv2656675 CNV deletion 23128226
esv2531384 CNV deletion 19546169
esv1270593 CNV insertion 17803354

Variation tolerance for RBMS3 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBMS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMS3 Gene

Disorders for RBMS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBMS3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
osteonecrosis of the jaw
- elite association - COSMIC cancer census association via MalaCards
Search RBMS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBMS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RBMS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBMS3 Gene

Publications for RBMS3 Gene

  1. Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins. (PMID: 10675610) Penkov D … Tanaka S (Gene 2000) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. (PMID: 19654303) Broderick P … Houlston RS (Cancer research 2009) 3 45 60
  4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 3 45 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for RBMS3 Gene

Sources for RBMS3 Gene

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