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Aliases for RBMS3 Gene

Aliases for RBMS3 Gene

  • RNA Binding Motif, Single Stranded Interacting Protein 3 2 3
  • RNA Binding Motif, Single Stranded Interacting Protein 2
  • RNA-Binding Protein 2

External Ids for RBMS3 Gene

Previous GeneCards Identifiers for RBMS3 Gene

  • GC03P028763
  • GC03P029172
  • GC03P029297
  • GC03P028880

Summaries for RBMS3 Gene

Entrez Gene Summary for RBMS3 Gene

  • This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

GeneCards Summary for RBMS3 Gene

RBMS3 (RNA Binding Motif, Single Stranded Interacting Protein 3) is a Protein Coding gene. Diseases associated with RBMS3 include osteonecrosis of the jaw. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for RBMS3 Gene

  • Binds poly(A) and poly(U) oligoribonucleotides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMS3 Gene

Genomics for RBMS3 Gene

Regulatory Elements for RBMS3 Gene

Genomic Location for RBMS3 Gene

29,280,860 bp from pter
30,010,395 bp from pter
729,536 bases
Plus strand

Genomic View for RBMS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBMS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMS3 Gene

Proteins for RBMS3 Gene

  • Protein details for RBMS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding motif, single-stranded-interacting protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K9S4
    • B7ZL17
    • G5E9J9
    • O75876
    • Q17RI0
    • Q6XE23

    Protein attributes for RBMS3 Gene

    437 amino acids
    Molecular mass:
    47840 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC63910.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305};

    Alternative splice isoforms for RBMS3 Gene


neXtProt entry for RBMS3 Gene

Proteomics data for RBMS3 Gene at MOPED

Post-translational modifications for RBMS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RBMS3 Gene

Domains for RBMS3 Gene

Gene Families for RBMS3 Gene

  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBMS3 Gene

Suggested Antigen Peptide Sequences for RBMS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6XE24
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBMS3: view

Function for RBMS3 Gene

Molecular function for RBMS3 Gene

UniProtKB/Swiss-Prot Function:
Binds poly(A) and poly(U) oligoribonucleotides.

Gene Ontology (GO) - Molecular Function for RBMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003730 mRNA 3-UTR binding IEA --
genes like me logo Genes that share ontologies with RBMS3: view

Animal Model Products

miRNA for RBMS3 Gene

miRTarBase miRNAs that target RBMS3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBMS3 Gene

Localization for RBMS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMS3 Gene


Subcellular locations from

Jensen Localization Image for RBMS3 Gene COMPARTMENTS Subcellular localization image for RBMS3 gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RBMS3: view

Pathways for RBMS3 Gene

SuperPathways for RBMS3 Gene

No Data Available

Interacting Proteins for RBMS3 Gene

Gene Ontology (GO) - Biological Process for RBMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045727 positive regulation of translation IEA --
genes like me logo Genes that share ontologies with RBMS3: view

No data available for Pathways by source for RBMS3 Gene

Compounds for RBMS3 Gene

(1) PharmGKB related drug/compound annotations for RBMS3 Gene

Drug/compound Annotation
Bisphosphonates CA
genes like me logo Genes that share compounds with RBMS3: view

Transcripts for RBMS3 Gene

Unigene Clusters for RBMS3 Gene

RNA binding motif, single stranded interacting protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMS3 Gene

No ASD Table

Relevant External Links for RBMS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBMS3 Gene

mRNA expression in normal human tissues for RBMS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RBMS3 Gene

This gene is overexpressed in Fetal testis (18.8), Gallbladder (15.4), Pancreas (9.2), Placenta (9.2), Fetal ovary (7.4), and Fetal heart (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBMS3 Gene

SOURCE GeneReport for Unigene cluster for RBMS3 Gene Hs.221436

mRNA Expression by UniProt/SwissProt for RBMS3 Gene

Tissue specificity: Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
genes like me logo Genes that share expressions with RBMS3: view

Expression partners for RBMS3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RBMS3 Gene

Orthologs for RBMS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBMS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBMS3 35
  • 95.34 (n)
  • 98.39 (a)
RBMS3 36
  • 98 (a)
(Canis familiaris)
Mammalia RBMS3 35
  • 97.56 (n)
  • 99.77 (a)
RBMS3 36
  • 100 (a)
(Mus musculus)
Mammalia Rbms3 35
  • 90.87 (n)
  • 94.9 (a)
Rbms3 16
Rbms3 36
  • 82 (a)
(Pan troglodytes)
Mammalia RBMS3 35
  • 99.85 (n)
  • 100 (a)
RBMS3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rbms3 35
  • 91.03 (n)
  • 95.36 (a)
(Monodelphis domestica)
Mammalia RBMS3 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia RBMS3 36
  • 94 (a)
(Gallus gallus)
Aves RBMS3 35
  • 91.17 (n)
  • 95.23 (a)
RBMS3 36
  • 92 (a)
(Anolis carolinensis)
Reptilia RBMS3 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbms3 35
  • 84.09 (n)
  • 92.33 (a)
(Danio rerio)
Actinopterygii rbms3 35
  • 79.27 (n)
  • 89.32 (a)
rbms3 36
  • 88 (a)
fruit fly
(Drosophila melanogaster)
Insecta shep 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea R10E4.2a 37
  • 51 (a)
R10E4.2b 37
  • 58 (a)
sup-26 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 36
  • 13 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3614 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1122 36
  • 44 (a)
Species with no ortholog for RBMS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBMS3 Gene

Gene Tree for RBMS3 (if available)
Gene Tree for RBMS3 (if available)

Paralogs for RBMS3 Gene

Selected SIMAP similar genes for RBMS3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBMS3: view

Variants for RBMS3 Gene

Sequence variations from dbSNP and Humsavar for RBMS3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs789 -- 29,355,524(+) CAAAC(A/G)AGGTG intron-variant
rs28150 -- 29,552,595(+) AATAG(A/C)AGTAG intron-variant
rs35875 -- 29,502,603(+) TGGAG(A/C)TGGCA intron-variant
rs35876 -- 29,505,900(+) acata(C/T)attac intron-variant
rs35877 -- 29,510,198(-) ATTCA(A/G)ACTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMS3 Gene

Variant ID Type Subtype PubMed ID
nsv876653 CNV Gain 21882294
essv9401 CNV CNV 17122850
dgv1444e1 CNV Complex 17122850
esv2678131 CNV Deletion 23128226
nsv521764 CNV Loss 19592680
nsv876656 CNV Gain 21882294
nsv876657 CNV Loss 21882294
esv2531384 CNV Deletion 19546169
esv1270593 CNV Insertion 17803354
esv2659346 CNV Deletion 23128226
nsv527860 CNV Loss 19592680
nsv818133 CNV Loss 17921354
esv29311 CNV Loss 19812545
nsv876658 CNV Loss 21882294
esv3696 CNV Deletion 18987735
esv2725078 CNV Deletion 23290073
esv2663180 CNV Deletion 23128226
nsv834650 CNV Gain 17160897
nsv10257 CNV Loss 18304495
esv2668775 CNV Deletion 23128226
esv275093 CNV Loss 21479260
esv2656675 CNV Deletion 23128226
esv8206 CNV Gain 19470904
esv2725079 CNV Deletion 23290073
nsv518057 CNV Loss 19592680
esv2725080 CNV Deletion 23290073
esv2725081 CNV Deletion 23290073
esv2725082 CNV Deletion 23290073
esv2725083 CNV Deletion 23290073
esv989202 CNV Insertion 20482838

Relevant External Links for RBMS3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMS3 Gene

Disorders for RBMS3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RBMS3 Gene in MalaCards »

(1) Diseases for RBMS3 Gene including...

Relevant External Links for RBMS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RBMS3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RBMS3 Gene

Publications for RBMS3 Gene

  1. Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins. (PMID: 10675610) Penkov D. … Tanaka S. (Gene 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 3 48
  5. Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. (PMID: 19654303) Broderick P. … Houlston R.S. (Cancer Res. 2009) 3 48

Products for RBMS3 Gene

Sources for RBMS3 Gene

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