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Aliases for RBMS2 Gene

Aliases for RBMS2 Gene

  • RNA Binding Motif Single Stranded Interacting Protein 2 2 3 5
  • Suppressor Of CDC2 With RNA-Binding Motif 3 3 4
  • SCR3 3 4
  • RNA-Binding Motif, Single-Stranded-Interacting Protein 2 3

External Ids for RBMS2 Gene

Previous GeneCards Identifiers for RBMS2 Gene

  • GC12P056808
  • GC12P057140
  • GC12P056632
  • GC12P055202
  • GC12P056915
  • GC12P053954

Summaries for RBMS2 Gene

Entrez Gene Summary for RBMS2 Gene

  • The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMS2 Gene

RBMS2 (RNA Binding Motif Single Stranded Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MIR4785.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMS2 Gene

Genomics for RBMS2 Gene

Regulatory Elements for RBMS2 Gene

Enhancers for RBMS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F056040 0.8 FANTOM5 ENCODE 39.6 -479.8 -479825 3.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 BAZ2A RNU6-343P RBMS2 RN7SL809P RPL41 ENSG00000258199 CDK2 STAT2 SUOX RAB5B
GH12F056718 0.6 ENCODE 38.2 +200.7 200735 8.9 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 MCM3 NEMP1 BAZ2A ANKRD52 RN7SL809P ENSG00000224713 TMEM198B ZC3H10 RNU6-343P CDK2 SMARCC2
GH12F057109 1.1 ENCODE 38.2 +589.4 589430 3.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 MCM3 SP3 NEMP1 BAZ2A ANKRD52 CTDSP2 RN7SL809P ENSG00000224713 ENSG00000258317 ZC3H10 TSPAN31 RNU6-343P
GH12F056519 0.6 Ensembl ENCODE 35.3 +3.3 3321 11.3 PKNOX1 ATF1 SIN3A FEZF1 GLI4 YY1 ZNF121 ZNF143 ZNF263 SP3 RBMS2 SPRYD4 GC12P056589
GH12F055827 0.6 ENCODE 30.1 -692.2 -692204 4.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 PHC1P1 ENSG00000258317 SMARCC2 BAZ2A RBMS2 ZC3H10 ANKRD52 RN7SL809P ENSG00000257740 RPL41
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBMS2 on UCSC Golden Path with GeneCards custom track

Promoters for RBMS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000431259 1176 3600 ATF1 FEZF1 GLI4 YY1 ZNF143 SP3 REST ZNF610 ZSCAN16 NBN

Genomic Location for RBMS2 Gene

56,521,824 bp from pter
56,596,196 bp from pter
74,373 bases
Plus strand

Genomic View for RBMS2 Gene

Genes around RBMS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMS2 Gene

Proteins for RBMS2 Gene

  • Protein details for RBMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding motif, single-stranded-interacting protein 2
    Protein Accession:

    Protein attributes for RBMS2 Gene

    407 amino acids
    Molecular mass:
    43959 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBMS2 Gene

neXtProt entry for RBMS2 Gene

Post-translational modifications for RBMS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for RBMS2
  • Santa Cruz Biotechnology (SCBT) Antibodies for RBMS2

No data available for DME Specific Peptides for RBMS2 Gene

Domains & Families for RBMS2 Gene

Gene Families for RBMS2 Gene

Protein Domains for RBMS2 Gene

Suggested Antigen Peptide Sequences for RBMS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RRM (RNA recognition motif) domains.
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBMS2: view

Function for RBMS2 Gene

Gene Ontology (GO) - Molecular Function for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,TAS 8041632
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBMS2: view
genes like me logo Genes that share phenotypes with RBMS2: view

Animal Model Products

miRNA for RBMS2 Gene

miRTarBase miRNAs that target RBMS2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMS2 Gene

Localization for RBMS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMS2 Gene

Subcellular locations from

Jensen Localization Image for RBMS2 Gene COMPARTMENTS Subcellular localization image for RBMS2 gene
Compartment Confidence
nucleus 5
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBMS2: view

Pathways & Interactions for RBMS2 Gene

SuperPathways for RBMS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 8041632
genes like me logo Genes that share ontologies with RBMS2: view

No data available for Pathways by source and SIGNOR curated interactions for RBMS2 Gene

Transcripts for RBMS2 Gene

Unigene Clusters for RBMS2 Gene

RNA binding motif, single stranded interacting protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMS2 Gene

No ASD Table

Relevant External Links for RBMS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBMS2 Gene

mRNA expression in normal human tissues for RBMS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBMS2 Gene

This gene is overexpressed in Lung (40.7) and Islet of Langerhans (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBMS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBMS2 Gene:


SOURCE GeneReport for Unigene cluster for RBMS2 Gene:

genes like me logo Genes that share expression patterns with RBMS2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RBMS2 Gene

Orthologs for RBMS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBMS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBMS2 34 35
  • 98.79 (n)
(Canis familiaris)
Mammalia RBMS2 34 35
  • 90.99 (n)
(Bos Taurus)
Mammalia RBMS2 34 35
  • 90.25 (n)
(Rattus norvegicus)
Mammalia Rbms2 34
  • 87.07 (n)
(Mus musculus)
Mammalia Rbms2 34 16 35
  • 86.02 (n)
(Ornithorhynchus anatinus)
Mammalia RBMS2 35
  • 62 (a)
(Gallus gallus)
Aves RBMS2 35
  • 62 (a)
(Anolis carolinensis)
Reptilia RBMS2 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbms2 34
  • 73.52 (n)
(Danio rerio)
Actinopterygii rbms2b 35
  • 73 (a)
rbms2a 34 35
  • 71.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta shep 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea R10E4.2b 36
  • 57 (a)
R10E4.2a 36
  • 53 (a)
sup-26 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1122 35
  • 42 (a)
Species where no ortholog for RBMS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBMS2 Gene

Gene Tree for RBMS2 (if available)
Gene Tree for RBMS2 (if available)

Paralogs for RBMS2 Gene

Variants for RBMS2 Gene

Sequence variations from dbSNP and Humsavar for RBMS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10450 -- 56,590,822(+) CTGTC(C/T)AGAGC utr-variant-3-prime
rs10605730 -- 56,539,027(+) TTTTT(-/TTTTTTT)GAGAC intron-variant
rs10676323 -- 56,558,591(+) TTCCT(-/TTTT)TTTTT intron-variant
rs10735863 -- 56,528,182(+) GAGGT(C/T)GAGGC intron-variant
rs10735864 -- 56,538,519(+) GTCTC(A/G)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMS2 Gene

Variant ID Type Subtype PubMed ID
esv1272042 CNV insertion 17803354
esv2662220 CNV deletion 23128226
esv3580280 CNV loss 25503493
nsv1043992 CNV gain 25217958
nsv1052713 CNV gain 25217958
nsv1116501 OTHER inversion 24896259
nsv1143564 CNV deletion 24896259
nsv475589 CNV novel sequence insertion 20440878
nsv476903 CNV novel sequence insertion 20440878
nsv482992 CNV gain+loss 15286789
nsv526706 CNV gain 19592680
nsv820140 CNV loss 19587683

Variation tolerance for RBMS2 Gene

Residual Variation Intolerance Score: 9.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBMS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMS2 Gene

Disorders for RBMS2 Gene

Relevant External Links for RBMS2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RBMS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMS2 Gene

Publications for RBMS2 Gene

  1. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. (PMID: 8041632) Kanaoka Y. … Nojima H. (Nucleic Acids Res. 1994) 2 3 4 64
  2. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z. … Kathiresan S. (PLoS Genet. 2012) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3 64

Products for RBMS2 Gene

Sources for RBMS2 Gene

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