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Aliases for RBMS1 Gene

Aliases for RBMS1 Gene

  • RNA Binding Motif, Single Stranded Interacting Protein 1 2 3
  • Suppressor Of Cdc 2 (Cdc13) With RNA Binding Motif 2 2 3
  • Suppressor Of CDC2 With RNA-Binding Motif 2 3 4
  • C-Myc Gene Single Strand Binding Protein 2 2 3
  • Single-Stranded DNA-Binding Protein MSSP-1 3 4
  • C2orf12 3 4
  • MSSP 3 4
  • SCR2 3 4
  • RNA-Binding Motif, Single-Stranded-Interacting Protein 1 3
  • Chromosome 2 Open Reading Frame 12 2
  • Cervical Cancer Oncogene 4 3
  • MSSP-1 3
  • MSSP-2 3
  • MSSP-3 3
  • MSSP1 4
  • HCC-4 3
  • YC1 3

External Ids for RBMS1 Gene

Previous HGNC Symbols for RBMS1 Gene

  • C2orf12

Previous GeneCards Identifiers for RBMS1 Gene

  • GC02M159061
  • GC02M159659
  • GC02M161094
  • GC02M161333
  • GC02M160956
  • GC02M160838
  • GC02M153011
  • GC02M161128

Summaries for RBMS1 Gene

Entrez Gene Summary for RBMS1 Gene

  • This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]

GeneCards Summary for RBMS1 Gene

RBMS1 (RNA Binding Motif, Single Stranded Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding and double-stranded DNA binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for RBMS1 Gene

  • Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5-[AT]CT[AT][AT]T-3. Probably has a role in DNA replication

Gene Wiki entry for RBMS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMS1 Gene

Genomics for RBMS1 Gene

Regulatory Elements for RBMS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBMS1 Gene

Start:
160,272,151 bp from pter
End:
160,493,855 bp from pter
Size:
221,705 bases
Orientation:
Minus strand

Genomic View for RBMS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBMS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMS1 Gene

Proteins for RBMS1 Gene

  • Protein details for RBMS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29558-RBMS1_HUMAN
    Recommended name:
    RNA-binding motif, single-stranded-interacting protein 1
    Protein Accession:
    P29558
    Secondary Accessions:
    • Q14869
    • Q15433
    • Q53P46
    • Q53QX8
    • Q53RG6
    • Q8WV20

    Protein attributes for RBMS1 Gene

    Size:
    406 amino acids
    Molecular mass:
    44505 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93095.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA45923.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA45923.1; Type=Frameshift; Positions=319, 360; Evidence={ECO:0000305}; Sequence=CAA54628.1; Type=Erroneous translation; Note=Wrong coding sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBMS1 Gene

    Alternative splice isoforms for RBMS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBMS1 Gene

Proteomics data for RBMS1 Gene at MOPED

Post-translational modifications for RBMS1 Gene

  • Ubiquitination at Lys207
  • Modification sites at PhosphoSitePlus

Other Protein References for RBMS1 Gene

Antibody Products

No data available for DME Specific Peptides for RBMS1 Gene

Domains for RBMS1 Gene

Gene Families for RBMS1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

P29558

UniProtKB/Swiss-Prot:

RBMS1_HUMAN :
  • P29558
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBMS1: view

Function for RBMS1 Gene

Molecular function for RBMS1 Gene

UniProtKB/Swiss-Prot Function: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5-[AT]CT[AT][AT]T-3. Probably has a role in DNA replication

Gene Ontology (GO) - Molecular Function for RBMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003690 double-stranded DNA binding NAS 7838710
GO:0003697 single-stranded DNA binding NAS 7838710
GO:0003723 RNA binding NAS 8041632
genes like me logo Genes that share ontologies with RBMS1: view
genes like me logo Genes that share phenotypes with RBMS1: view

Animal Models for RBMS1 Gene

MGI Knock Outs for RBMS1:

Animal Model Products

CRISPR Products

miRNA for RBMS1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RBMS1 Gene

Localization for RBMS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBMS1 Gene COMPARTMENTS Subcellular localization image for RBMS1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RBMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7838710
genes like me logo Genes that share ontologies with RBMS1: view

Pathways for RBMS1 Gene

SuperPathways for RBMS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication NAS 7838710
GO:0006396 RNA processing TAS 8041632
genes like me logo Genes that share ontologies with RBMS1: view

No data available for Pathways by source for RBMS1 Gene

Transcripts for RBMS1 Gene

Unigene Clusters for RBMS1 Gene

RNA binding motif, single stranded interacting protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBMS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMS1 Gene

No ASD Table

Relevant External Links for RBMS1 Gene

GeneLoc Exon Structure for
RBMS1
ECgene alternative splicing isoforms for
RBMS1

Expression for RBMS1 Gene

mRNA expression in normal human tissues for RBMS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBMS1 Gene

SOURCE GeneReport for Unigene cluster for RBMS1 Gene Hs.470412

mRNA Expression by UniProt/SwissProt for RBMS1 Gene

P29558-RBMS1_HUMAN
Tissue specificity: Highest amounts are found in placenta, lung and heart
genes like me logo Genes that share expressions with RBMS1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RBMS1 Gene

Orthologs for RBMS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBMS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBMS1 35
  • 99.75 (n)
  • 100 (a)
RBMS1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBMS1 35
  • 93.63 (n)
  • 98.76 (a)
RBMS1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBMS1 35
  • 94.4 (n)
  • 98.16 (a)
RBMS1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbms1 35
  • 90.9 (n)
  • 96.77 (a)
Rbms1 16
Rbms1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBMS1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBMS1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbms1 35
  • 91.56 (n)
  • 97.02 (a)
chicken
(Gallus gallus)
Aves RBMS1 35
  • 84.75 (n)
  • 92.9 (a)
RBMS1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBMS1 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rbms1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbms1 35
  • 81.81 (n)
  • 89.63 (a)
Str.7567 35
zebrafish
(Danio rerio)
Actinopterygii RBMS1 (1 of 2) 36
  • 70 (a)
OneToMany
rbms1a 35
  • 70.4 (n)
  • 74.71 (a)
rbms1a 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta shep 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sup-26 36
  • 29 (a)
OneToMany
R10E4.2b 37
  • 59 (a)
R10E4.2a 37
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1122 36
  • 43 (a)
OneToMany
Species with no ortholog for RBMS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBMS1 Gene

ENSEMBL:
Gene Tree for RBMS1 (if available)
TreeFam:
Gene Tree for RBMS1 (if available)

Paralogs for RBMS1 Gene

Selected SIMAP similar genes for RBMS1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for RBMS1 Gene

genes like me logo Genes that share paralogs with RBMS1: view

Variants for RBMS1 Gene

Sequence variations from dbSNP and Humsavar for RBMS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1430 -- 160,318,182(-) ACAAC(A/G)AACAA synonymous-codon, reference
rs2442 -- 160,490,641(+) ACTGG(A/G)TCACT intron-variant
rs716614 -- 160,280,362(-) GTGAT(A/G)AAATA intron-variant
rs716615 -- 160,280,479(-) TTTTA(A/G)AGTGG intron-variant
rs1020731 -- 160,287,544(+) TGCTC(A/G)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBMS1 Gene

Variant ID Type Subtype PubMed ID
dgv743e199 CNV Deletion 23128226
esv2721039 CNV Deletion 23290073
esv2721041 CNV Deletion 23290073
esv991493 CNV Deletion 20482838
esv1606282 CNV Deletion 17803354
nsv821774 CNV Gain 20364138
nsv2998 CNV Insertion 18451855
esv2672047 CNV Deletion 23128226
nsv3000 CNV Insertion 18451855
nsv3001 CNV Loss 18451855

Relevant External Links for RBMS1 Gene

HapMap Linkage Disequilibrium report
RBMS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMS1 Gene

Disorders for RBMS1 Gene

Relevant External Links for RBMS1

Genetic Association Database (GAD)
RBMS1
Human Genome Epidemiology (HuGE) Navigator
RBMS1
genes like me logo Genes that share disorders with RBMS1: view

No data available for UniProtKB/Swiss-Prot for RBMS1 Gene

Publications for RBMS1 Gene

  1. Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity. (PMID: 7838710) Takai T. … Ariga H. (Nucleic Acids Res. 1994) 2 3 4 23
  2. Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene. (PMID: 8134115) Negishi Y. … Ariga H. (Oncogene 1994) 2 3 4 23
  3. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. (PMID: 8041632) Kanaoka Y. … Nojima H. (Nucleic Acids Res. 1994) 2 3 4
  4. Cloning and characterization of the genomic DNA of the human MSSP genes. (PMID: 8871567) Haigermoser C. … Ariga H. (Nucleic Acids Res. 1996) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RBMS1 Gene

Sources for RBMS1 Gene

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