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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBMS1 Gene

protein-coding   GIFtS: 55
GCID: GC02M161128

RNA binding motif, single stranded interacting protein 1

(Previous name: chromosome 2 open reading frame 12 )
(Previous symbol: C2orf12)
 Explore 8 diseases affiliated with
RBMS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RBMS1    

Aliases
for RBMS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RNA Binding Motif, Single Stranded Interacting Protein 11 2     Suppressor Of CDC2 With RNA-Binding Motif 22 3
C2orf121 2 3     MSSP2 3
SCR21 2 3     DKFZp564H07641
HCC-41 2     Chromosome 2 Open Reading Frame 121
MSSP-11 2     C-Myc Gene Single Strand Binding Protein 22
MSSP-21 2     Cervical Cancer Oncogene 42
MSSP-31 2     RNA-Binding Motif, Single-Stranded-Interacting Protein 12
YC11 2     Suppressor Of Cdc 2 (Cdc13) With RNA Binding Motif 22
Single-Stranded DNA-Binding Protein MSSP-12 3     MSSP13

External Ids:    HGNC: 99071   Entrez Gene: 59372   Ensembl: ENSG000001532507   OMIM: 6023105   UniProtKB: P295583   

Export aliases for RBMS1 gene to outside databases

Previous GC identifers: GC02M159061 GC02M159659 GC02M161094 GC02M161333 GC02M160956 GC02M160838 GC02M153011


Summaries
for RBMS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RBMS1:
This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are
characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved
motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have
been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and
apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been
described. A pseudogene for this locus is found on chromosome 12. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: RBMS1_HUMAN, P29558
Function: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds
specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication

Gene Wiki entry for RBMS1


Genomic Views
for RBMS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBMS1 gene promoter:
         CREB   deltaCREB   LHX3a/Lhx3a   NRSF form 2   GATA-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RBMS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBMS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBMS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24.2

RBMS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBMS1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M161128:  view genomic region     (about GC identifiers)

Start:
 161,128,662 bp from pter      End:
 161,350,318 bp from pter
Size:
 221,657 bases      Orientation:
 minus strand

Proteins
for RBMS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RBMS1_HUMAN, P29558 (See protein sequence)
Recommended Name: RNA-binding motif, single-stranded-interacting protein 1  
Size: 406 amino acids; 44505 Da
Subcellular location: Nucleus
Developmental stage: Expressed at highest levels during the G1 to S transition of the cell cycle
Sequence caution: Sequence=AAX93095.1; Type=Erroneous gene model prediction; Sequence=CAA45923.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAA45923.1; Type=Frameshift; Positions=319, 360;
Sequence=CAA54628.1; Type=Erroneous translation; Note=Wrong coding sequence;
1 PDB 3D structure from and Proteopedia for RBMS1:
1X5O (3D)    
Secondary accessions: Q14869 Q15433 Q53P46 Q53QX8 Q53RG6 Q8WV20
Alternative splicing: 3 isoforms:  P29558-1   P29558-2   P29558-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RBMS1: NX_P29558

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29558

    • RBMS1 Protein expression data from MOPED and PaxDb:    About this image 
    RBMS1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002888.1  NP_058520.1  

    ENSEMBL proteins: 
     ENSP00000294904   ENSP00000386347   ENSP00000386571   ENSP00000387280   ENSP00000389016  
     ENSP00000376508  

    Human Recombinant Protein Products for RBMS1: 
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    OriGene Protein Over-expression Lysate (see all 4): RBMS1
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    Novus Biologicals RBMS1 Proteins
    Novus Biologicals RBMS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RBMS1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7838710

    RBMS1 for ontologies           About GeneDecksing



    RBMS1 Antibody Products: 
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    Abcam antibodies for RBMS1 
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    Search ThermoFisher Antibodies for RBMS1

    Assay Products for RBMS1: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for RBMS1

    Protein Domains /
    Families
    for RBMS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RBMS1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR002343 Hud_Sxl_RNA

    Graphical View of Domain Structure for InterPro Entry P29558

    ProtoNet protein and cluster: P29558

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001199 Cytochrome b5


    UniProtKB/Swiss-Prot: RBMS1_HUMAN, P29558
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for RBMS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBMS1_HUMAN, P29558
    Function: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds
    specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003690double-stranded DNA binding NAS7838710
    GO:0003697single-stranded DNA binding NAS7838710
    GO:0003723RNA binding NAS8041632
         
    RBMS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RBMS1:
     Decreased viability with pacli 

         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rbms1):
     embryogenesis  growth/size  homeostasis/metabolism  mortality/aging  reproductive system 

    RBMS1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Rbms1tm1Hiro for RBMS1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RBMS1 

    miRNA
    Products:            		miRTarBase miRNAs that target RBMS1:
    hsa-mir-30a (MIRT005194)

    OriGene 3'-UTR Clone (see all 2): RBMS1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBMS1
    8/158 QIAGEN miScript miRNA Assays for microRNAs that regulate RBMS1 (see all 158):
    hsa-miR-579 hsa-miR-1321 hsa-miR-193a-3p hsa-miR-376b hsa-miR-106a hsa-miR-1245 hsa-miR-3916 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RBMS1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBMS1 (see all 7)
    OriGene shRNA RFP: RBMS1
    OriGene siRNA: RBMS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBMS1
    Sirion Biotech Custom design and validation of potent shRNA sequences against RBMS1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RBMS1
    Sirion Biotech Customized adenovirus for overexpression of RBMS1 
    Sirion Biotech Customized adenovirus for potent knockdown of RBMS1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBMS1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBMS1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RBMS1 (NM_016836)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBMS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBMS1 

    Cell Line
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    Search LifeMap BioReagents cell lines for RBMS1
    Sirion Biotech Customized stable knockdown cell line services for RBMS1 
    Sirion Biotech Customized inducible knockdown cell line services for RBMS1
    Sirion Biotech Customized stable overexpressing cell line services for RBMS1
    Sirion Biotech Customized inducible overexpressing cell line services for RBMS1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMS1


    Pathways & Interactions
    for RBMS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBMS1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for RBMS1 (P295583 ENSP000002949044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA1P098843, ENSP000003683494I2D: score=2 STRING: ENSP00000368349
    NSFP464593I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication NAS7838710
    GO:0006396RNA processing TAS8041632

    RBMS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RBMS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBMS1
    Search CenterWatch for drugs/clinical trials and news about RBMS1 

    Transcripts
    for RBMS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RBMS1 gene (3 alternative transcripts): 
    NM_002897.4  NM_016836.3  NM_016839.2  

    Unigene Cluster for RBMS1:

    RNA binding motif, single stranded interacting protein 1
    Hs.470412  [show with all ESTs]
    Unigene Representative Sequence: NM_016836
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474820 ENST00000348849(uc002ubn.3 uc002ubo.3 uc002ubi.4 uc002ubm.3 uc002ubp.3)
    ENST00000474147 ENST00000409075 ENST00000409289 ENST00000475103 ENST00000490637
    ENST00000409972 ENST00000477965 ENST00000464200 ENST00000491781(uc010fox.2)
    ENST00000492283 ENST00000428519 ENST00000477486 ENST00000392753

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): RBMS1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBMS1
    8/158 QIAGEN miScript miRNA Assays for microRNAs that regulate RBMS1 (see all 158):
    hsa-miR-579 hsa-miR-1321 hsa-miR-193a-3p hsa-miR-376b hsa-miR-106a hsa-miR-1245 hsa-miR-3916 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RBMS1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBMS1 (see all 7)
    OriGene shRNA RFP: RBMS1
    OriGene siRNA: RBMS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBMS1
    Sirion Biotech Custom design and validation of potent shRNA sequences against RBMS1 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBMS1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBMS1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RBMS1 (NM_016836)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBMS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBMS1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBMS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBMS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBMS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBMS1

    Additional cDNA sequence: 

    AK225887.1 AK297812.1 AK309949.1 AL117617.1 BC012992.2 BC012993.2 BC018951.2 BC051889.1 
    BC065192.1 BC069687.1 BC069706.1 BC069763.1 BC080620.1 D28482.1 L11289.1 X64652.1 
    X77494.1 

    24/25 DOTS entries (see all 25):

    DT.100788574  DT.97797780  DT.100792078  DT.91775112  DT.100792081  DT.91775105  DT.121004796  DT.95091813 
    DT.100792084  DT.97762881  DT.40113755  DT.97846341  DT.100792082  DT.100792087  DT.100788575  DT.100792080 
    DT.206572  DT.121004783  DT.100792089  DT.100645517  DT.100788576  DT.121004788  DT.100792083  DT.91775107 

    24/563 AceView cDNA sequences (see all 563):

    BU687601 BC080620 AI223340 BQ720373 AA329848 BC037862 BM842637 BQ694000 
    BC069706 AA953117 CA427450 BG029680 CB106709 BG825722 D28482 BX097389 
    BM423371 BC018951 AI581627 BQ720591 AW609134 AA045045 AI302889 AK127157 

    GeneLoc Exon Structure


    Expression
    for RBMS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBMS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGAAGATT
    RBMS1 Expression
    About this image

    RBMS1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RBMS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBMS1

    SOURCE GeneReport for Unigene cluster: Hs.470412

    UniProtKB/Swiss-Prot: RBMS1_HUMAN, P29558
    Tissue specificity: Highest amounts are found in placenta, lung and heart

        SABiosciences Custom PCR Arrays for RBMS1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBMS1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBMS1

    Orthologs
    for RBMS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBMS1 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RBMS11 RNA binding motif, single stranded interacting protein more 85.25(n)
    93.3(a)    		   395880  NM_205024.1  NP_990355.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RBMS16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343371.1(559285-618326)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rbms1-prov2 RNA binding motif, single stranded interacting protein more 87.42(n)    BC043623.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570746072   -- 76.19(n)    57074607 
    fruit fly
    (Drosophila melanogaster)    		 Insecta shep6
    		 alan shepard
    		 28(a)
    		 1 → many
    		 3L(5148921-5271044)
    worm
    (Caenorhabditis elegans)    		 Secernentea R10E4.2b3 RNA recognition motif. (aka RRM, RBD, or RNP
    domain) more    		 59(a)
    (best of 2)    		   III(4349152-4351056)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G473106
    FCA6
    		 RNA binding / abscisic acid binding protein
    		 8(a)
    7(a)
    		 many ↔ many
    many ↔ many
    		 2(19423684-19427277)
    4(9206597-9214825)
    rice
    (Oryza sativa)    		 Liliopsida FCA6
    		 flowering time control protein FCA, putative, expr...
    		 7(a)
    		 1 → many
    		 9(1789446-1798611)


    ENSEMBL Gene Tree for RBMS1 (if available)
    TreeFam Gene Tree for RBMS1 (if available) 

    Paralogs
    for RBMS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RBMS1 gene
    PABPC1L2  PABPC52  PABPC42  PABPC4L2  ELAVL12  ELAVL42  ELAVL32  RBMS32  
    PABPC32  ELAVL22  PABPC1L2B2  PABPC1L2A2  PUF602  RBMS22  PABPC12  
    11 SIMAP similar genes for RBMS1 using alignment to 5 protein entries:     RBMS1_HUMAN (see all proteins):
    RBMS3    RBMS2    CELF4    CELF3    ELAVL1    PABPC4L
    ELAVL2    DAZAP1    PABPC3    PABPC4    PABPC1

    RBMS1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RBMS1
    PGOHUM00000239501


    Genomic Variants
    for RBMS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3064 NCBI SNPs in RBMS1 are shown (see all 3064)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs726231251,2
    		F--161128206(+) CCCGAG/CGTTCT 2 -- ds50012Minor allele frequency- C:0.17NA EA 240
    rs1166427571,2
    		--161128397(+) GAGCCG/CACCGT 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1387306521,2
    		--161128407(+) TTGACA/GTGCTG 2 -- ds50010--------
    rs121046471,2
    		A--161128419(+) GCTGAC/GGGTTG 2 -- ds50010--------
    rs1890222621,2
    		--161128475(+) AAATAA/CCCAGC 2 -- ds50010--------
    rs1493435941,2
    		--161128507(+) TTCCAA/GTTGTT 2 -- ds50010--------
    rs560060821,2
    		C--161128719(+) AAGCTA/GACAAT 2 -- ut310--------
    rs1813974251,2
    		--161128876(+) TCTTGA/CTCATA 2 -- ut310--------
    rs562306881,2
    		C--161129240(+) ACCAAC/TAATAC 2 -- ut310--------
    rs1446685841,2
    		--161129322(+) AGAATC/TTACAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RBMS1 (161128662 - 161350318 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RBMS1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RBMS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RBMS1 for disorders           About GeneDecksing

    OMIM gene information: 602310    OMIM disorders: --

    8 diseases for RBMS1:    About MalaCards
    cervical cancer    cervicitis    amyotrophic lateral sclerosis    lateral sclerosis
    cholesterol embolism    measles    nephropathy    malaria

    Human Genome Epidemiology (HuGE) Navigator: RBMS1 (4 documents)

    Export disorders for RBMS1 gene to outside databases

    Publications
    for RBMS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBMS1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with RBMS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity. (PubMed id 7838710)1, 2, 3, 9 Takai T.... Ariga H. (1994)
    2. Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene. (PubMed id 8134115)1, 2, 3, 9 Negishi Y.... Ariga H. (1994)
    3. SCR: novel human suppresors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. (PubMed id 8041632)1, 2, 3 Kanaoka Y. and Nojima H. (1994)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity. (PubMed id 10869558)1, 9 Niki T....Iguchi-Ariga S.M. (2000)
    7. Cloning and characterization of the genomic DNA of the human MSSP genes. (PubMed id 8871567)1, 9 Haigermoser C.... Ariga H. (1996)
    8. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for RBMS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing RBMS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5937 HGNC: 9907 AceView: RBMS1 Ensembl:ENSG00000153250 euGenes: HUgn5937
    ECgene: RBMS1 H-InvDB: RBMS1

    Other Databases showing RBMS1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RBMS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBMS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RBMS1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RBMS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RBMS1 gene:
    Search GeneIP for patents involving RBMS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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