RBM8A Gene
protein-coding GIFtS : 62 GCID: GC01 P145507
RNA binding motif protein 8A RBM8 )
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Aliasesfor RBM8A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RNA Binding Motif Protein 8A 1 2 RNA-Binding Motif Protein 8A2 3 RBM81 2 3 RNA-Binding Protein Y142 3 RBM8B1 2 5 C1DELq21.12 BOV-1A1 2 DEL1q21.12 BOV-1B1 2 MDS0142 BOV-1C1 2 TAR2 Y141 2 ZRNP12 ZNRP1 2 Ribonucleoprotein RBM82 Binder Of OVCA1-12 3 RNA Binding Motif Protein 8B2 Ribonucleoprotein RBM8A2 3 RNA-Binding Protein 8A2 BOV-12 3
Export aliases for RBM8A gene to outside databases Previous GC identifers: GC01P144028 GC01P142094 GC01P143234 GC01P143256 GC01P142996 GC01P144218 GC01P119471
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Summariesfor RBM8A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RBM8A : This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: RBM8A_HUMAN, Q9Y5S9 Function : Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction onmRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway Gene Wiki entry for RBM8A
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Genomic Viewsfor RBM8A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_167185.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RBM8A gene promoter:HOXA3 AML1a HNF-1A C/EBPalpha GATA-2 FAC1 HSF2 HNF-1 Sox9 Chx10 Other transcription factors Search SABiosciences Chromatin IP Primers for RBM8A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM8A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1 RBM8A Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P145507: view genomic region
(about GC identifiers )
Start: 145,507,598 bp from pter End:
145,511,444 bp from pter
Size: 3,847 bases Orientation:
plus strand
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Proteinsfor RBM8A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RBM8A_HUMAN, Q9Y5S9 See
protein sequence )Recommended Name: Size : 174 amino acids; 19889 DaSubunit : Heterodimer with MAGOH. Part of the exon junction complex (EJC) core complex that contains CASC3, EIF4A3,MAGOH and RBM8A. Found in a mRNA splicing-dependent EJC, at least composed of ACIN1, CASC3, DEK, EIF4A3, MAGOH, NCBP1, NCBP2, PNN, NXF1, RBM8A, UPF2, UPF3A, UPF3B, RNPS1, SAP18, SRRM1 and ALYREF/THOC4. Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Interacts with BAT1, MAGOH, OVCA1, UPF3B, RNPS1, SRRM1 and ALYREF/THOC4. Identified in the spliceosome C complex. Interacts with WIBG/PYM; the interaction is direct and leads to dissociate the EJC from spliced mRNAs. Associates with polysomes
Subcellular location : Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to thecytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles
Sequence caution : Sequence=AAG14951.1; Type=Erroneous initiation; Sequence=AAG16782.1; Type=Erroneous initiation;Sequence=AAG16782.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 1 and 5;
6 PDB 3D structures from :1P27 (3D) 2HYI (3D) 2J0Q (3D) 2J0S (3D) 2XB2 (3D) 3EX7 (3D) Secondary accessions : B3KQI9 Q6FHD1 Q6IQ40 Q9GZX8 Q9NZI4Alternative splicing : 2 isoforms : Q9Y5S9-1 Q9Y5S9-2 Explore the universe of human proteins at neXtProt for RBM8A: NX_Q9Y5S9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9Y5S9 RBM8A Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_005096.1 ENSEMBL proteins: ENSP00000333001 ENSP00000358313 Reactome Protein details: Q9Y5S9 Human Recombinant Protein Products for RBM8A: Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing RBM8A Antibody Products: Assay Products for RBM8A:
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Protein
Domains /for RBM8A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9Y5S9 ProtoNet protein and cluster: Q9Y5S9
2 Blocks protein families : IPB000504 IPB008111 UniProtKB/Swiss-Prot: RBM8A_HUMAN, Q9Y5S9 Similarity : Belongs to the RBM8A familySimilarity : Contains 1 RRM (RNA recognition motif) domain
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Functionfor RBM8A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: RBM8A_HUMAN, Q9Y5S9 Function : Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction onmRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 8 GenomeRNAi human phenotypes for RBM8A :Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RBM8A (NM_005105 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM8A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBM8A
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM8A
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Pathways & Interactionsfor RBM8A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/9 super-pathways (see all 9 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 RNA Polymerase II Transcription Termination 2 mRNA Splicing - Major Pathway 3 Synthesis of PB1-F2 4 Metabolism of mRNA 5 Transcription
Pathway sources See GeneCards unified pathways Show all pathways 5/20 (see all 20 )3 (Kegg details for RBM8A) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBM8A STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/208 Interacting proteins for RBM8A (Q9Y5S9 1 , 2 , 3 ENSP00000333001 4 via UniProtKB, MINT, STRING , and/or I2D (see all 208 )Interactant Interaction Details GeneCard External ID(s) UPF3B Q9BZI7 1 , 2 , 3 ENSP00000276201 4 EBI-447231,EBI-372780 MINT-18282 I2D:
score=3 STRING: ENSP00000276201 MAGOHB Q96A72 2 , 3 ENSP00000319240 4 MINT-68487 I2D:
score=10 STRING: ENSP00000319240 MAGOH P61326 1 , 2 , 3 ENSP00000360525 4 EBI-447231,EBI-299134 MINT-8337860 I2D:
score=5 STRING: ENSP00000360525 EIF4A3 P38919 1 , 3 ENSP00000269349 4 EBI-447231,EBI-299104 I2D:
score=3 STRING: ENSP00000269349 UPF3A Q9H1J1 1 , 3 ENSP00000364448 4 EBI-447231,EBI-521530 I2D:
score=4 STRING: ENSP00000364448
About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
TAS -- GO:0000398 mRNA splicing, via spliceosome
TAS -- GO:0006366 transcription from RNA polymerase II promoter
TAS -- GO:0006369 termination of RNA polymerase II transcription
TAS -- GO:0006406 mRNA export from nucleus
TAS --
About GeneDecksing
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Drugs & Compoundsfor RBM8A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for RBM8A 3 Novoseek chemical compound relationships for RBM8A gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
gnrh
19.8
1
12538601 (1)
atp
7.2
2
16170325 (1), 16923391 (1)
arginine
5.39
3
16100109 (2)
RBM8A
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Transcriptsfor RBM8A gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RBM8A gene: NM_005105.3 Unigene Cluster for RBM8A:
RNA binding motif protein 8A Hs.591455 [show with all ESTs ] Unigene Representative Sequence: NM_005105 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000484825 ENST00000498663 ENST00000330165 (uc001ent.2 uc001enu.2 )ENST00000369307 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RBM8A (NM_005105 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM8A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBM8A
Additional cDNA sequence: AF127761.1 AF161463.1 AF182415.1 AF198620.1 AF231511.1 AF299118.1 AK075009.1 AL049219.1 BC017088.2 BC017770.1 CR541805.1 CR541823.1
24/28 DOTS entries (see all 28 ): DT.86854958 DT.447841
DT.95161012 DT.95161011 DT.92397337 DT.121360222 DT.95340151 DT.95340149 DT.100709242 DT.100830866 DT.91777441 DT.95161010 DT.120782765 DT.120782768 DT.91777447 DT.121360291 DT.95340152 DT.100806360 DT.121360202 DT.121360256 DT.121360263 DT.121360282 DT.121360285 DT.40114765 24/710 AceView cDNA sequences (see all 710 ):
BU782901 AF127761 BM840661 BP349096 CR608642 AF198620 F02962 BU158698 BE701623 BU675148 CR541805 AA302214 W16687 BP354213 BQ374179 BE253253 AF161463 AA298568 AW070926 AI079701 T08302 BE875797 BU739397 CF129030 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RBM8A (see all 9 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 SP1 : - - - - - SP2 : - - SP3 : - - SP4 : - - - SP5 : - -
ECgene alternative splicing isoforms for RBM8A
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Expression for RBM8A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RBM8A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGCCTTGGAAbout this image RBM8A expression in embryonic tissues and stem cells About this table
1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Heart Right Ventricle Heart Expression: Experimental details:
In-situ hybridization
See RBM8A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RBM8A SOURCE GeneReport for Unigene cluster: Hs.591455 UniProtKB/Swiss-Prot: RBM8A_HUMAN, Q9Y5S9 Tissue specificity : UbiquitousSABiosciences Custom PCR Arrays for RBM8A Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM8A
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Orthologsfor RBM8A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for RBM8A gene from 7/33 species (see all 33 ) About this table
ENSEMBL Gene Tree for RBM8A (if available)TreeFam Gene Tree for RBM8A (if available)
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Paralogsfor RBM8A gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RBM8A gene CSTF2T 2 CSTF2 2 About GeneDecksing
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Genomic Variantsfor RBM8A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 1 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for RBM8A (145507598 - 145511444 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for RBM8A 3 CNVs 2324 5199 53561 Human Gene Mutation Database (HGMD) : RBM8A SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor RBM8A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 605313
OMIM disorders : --1 : About MalaCards malaria 1 disease from the University of Copenhagen DISEASES database for RBM8A :Developmental coordination disorder Export disorders for RBM8A gene to outside databases
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Publicationsfor RBM8A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RBM8A gene, integrated from 9 sources (see all 90 ):(articles sorted by number of sources associating them with RBM8A) Utopia : connect your pdf to the dynamic
Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor. (PubMed id 11013075) 1 , 2 , 3(2000) Cloning and gene expression of a novel human ribonucleoprotein. (PubMed id 11004516) 1 , 2 , 3(2000) Y14 and hUpf3b form an NMD-activating complex. (PubMed id 12718880) 1 , 2 , 9(2003) MAGOH interacts with a novel RNA-binding protein. (PubMed id 10662555) 1 , 2 , 9(2000) Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA- binding protein that persists in the cytoplasm. (PubMed id 11030346) 1 , 2 , 9(2000) Structure of the Y14-Magoh core of the exon junction complex. (PubMed id 12781131) 1 , 2 , 9(2003) The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. (PubMed id 11707068) 1 , 2 , 9(2001) PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PubMed id 18026120) 1 , 2 , 9(2007) The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PubMed id 16170325) 1 , 2 , 9(2005) Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. (PubMed id 11707413) 1 , 2 , 9(2001)
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About This Section Patent Information for RBM8A gene: RBM8A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RBM8A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RBM8A OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for RBM8A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RBM8A OriGene 3'-UTR Clone for RBM8A OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RBM8A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBM8A QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM8A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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