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Aliases for RBM7 Gene

Aliases for RBM7 Gene

  • RNA Binding Motif Protein 7 2 3 5
  • RNA-Binding Motif Protein 7 4

External Ids for RBM7 Gene

Previous GeneCards Identifiers for RBM7 Gene

  • GC11P116624
  • GC11P115783
  • GC11P114305
  • GC11P113808
  • GC11P113776
  • GC11P110199
  • GC11P114270

Summaries for RBM7 Gene

GeneCards Summary for RBM7 Gene

RBM7 (RNA Binding Motif Protein 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ENSG00000255663.

UniProtKB/Swiss-Prot for RBM7 Gene

  • Possible involved in germ cell RNA processing and meiosis.

Gene Wiki entry for RBM7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM7 Gene

Genomics for RBM7 Gene

Regulatory Elements for RBM7 Gene

Enhancers for RBM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F114288 0.9 ENCODE 32 -104.6 -104576 13.1 PKNOX1 ARNT FEZF1 ZNF2 YY1 FOS ZNF263 SP3 SP5 REST RBM7 ZW10 LOC101928940 NNMT REXO2 ENSG00000270179 C11orf71 ENSG00000255663 NXPE1 GC11P114306
GH11F113772 0.5 ENCODE 29.8 -626.7 -626687 1.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 RBM7 REXO2 ZW10 LOC101928940 NNMT ENSG00000270179 NXPE1 DRD2 ENSG00000256603
GH11F114398 1.1 ENCODE 27.3 +0.4 416 3.8 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 RBM7 ZW10 C11orf71 ENSG00000282682
GH11F114152 2.2 FANTOM5 Ensembl ENCODE 21.5 -229.5 -229508 35.9 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 SP5 LRRC37A13P RBM7 ZW10 NXPE2P1 ZBTB16 NNMT LOC101928940 ENSG00000270179 REXO2 HTR3A
GH11F114377 1.1 ENCODE 17.1 -22.0 -21978 1.4 JUND FOS RBM7 C11orf71 ENSG00000255663 LOC101928940 ENSG00000256947
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBM7 on UCSC Golden Path with GeneCards custom track

Promoters for RBM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000112049 570 4001 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for RBM7 Gene

Chromosome:
11
Start:
114,400,030 bp from pter
End:
114,414,203 bp from pter
Size:
14,174 bases
Orientation:
Plus strand

Genomic View for RBM7 Gene

Genes around RBM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM7 Gene

Proteins for RBM7 Gene

  • Protein details for RBM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y580-RBM7_HUMAN
    Recommended name:
    RNA-binding protein 7
    Protein Accession:
    Q9Y580
    Secondary Accessions:
    • B2R6K8
    • Q9NUT4

    Protein attributes for RBM7 Gene

    Size:
    266 amino acids
    Molecular mass:
    30504 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBM7 Gene

neXtProt entry for RBM7 Gene

Post-translational modifications for RBM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM7 Gene

Domains & Families for RBM7 Gene

Protein Domains for RBM7 Gene

Suggested Antigen Peptide Sequences for RBM7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y580

UniProtKB/Swiss-Prot:

RBM7_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBM7: view

Function for RBM7 Gene

Molecular function for RBM7 Gene

UniProtKB/Swiss-Prot Function:
Possible involved in germ cell RNA processing and meiosis.

Gene Ontology (GO) - Molecular Function for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003727 single-stranded RNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM7: view
genes like me logo Genes that share phenotypes with RBM7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM7 Gene

Localization for RBM7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM7 Gene COMPARTMENTS Subcellular localization image for RBM7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with RBM7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RBM7 Gene

Pathways & Interactions for RBM7 Gene

SuperPathways for RBM7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with RBM7: view

No data available for Pathways by source and SIGNOR curated interactions for RBM7 Gene

Transcripts for RBM7 Gene

Unigene Clusters for RBM7 Gene

RNA binding motif protein 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for RBM7 Gene

GeneLoc Exon Structure for
RBM7
ECgene alternative splicing isoforms for
RBM7

Expression for RBM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM7 Gene

This gene is overexpressed in Lung (39.4) and Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM7 Gene



Protein tissue co-expression partners for RBM7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM7 Gene:

RBM7

SOURCE GeneReport for Unigene cluster for RBM7 Gene:

Hs.7527

mRNA Expression by UniProt/SwissProt for RBM7 Gene:

Q9Y580-RBM7_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with RBM7: view

Primer Products

No data available for mRNA differential expression in normal tissues for RBM7 Gene

Orthologs for RBM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM7 34 35
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia RBM7 34 35
  • 90.46 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 90 (a)
OneToMany
RBM7 34
  • 89.06 (n)
mouse
(Mus musculus)
Mammalia Rbm7 34 16 35
  • 85.16 (n)
rat
(Rattus norvegicus)
Mammalia Rbm7 34
  • 83.42 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves RBM7 34 35
  • 64.57 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735152 34
  • 69.86 (n)
Str.10735 34
African clawed frog
(Xenopus laevis)
Amphibia rbm7-prov 34
zebrafish
(Danio rerio)
Actinopterygii zgc:77304 34
  • 55.04 (n)
RBM7 35
  • 43 (a)
OneToMany
wufa03f03 34
fruit fly
(Drosophila melanogaster)
Insecta CG11454 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y37D8A.21 35
  • 23 (a)
OneToMany
Species where no ortholog for RBM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM7 Gene

ENSEMBL:
Gene Tree for RBM7 (if available)
TreeFam:
Gene Tree for RBM7 (if available)

Paralogs for RBM7 Gene

Paralogs for RBM7 Gene

Pseudogenes.org Pseudogenes for RBM7 Gene

genes like me logo Genes that share paralogs with RBM7: view

Variants for RBM7 Gene

Sequence variations from dbSNP and Humsavar for RBM7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10502184 -- 114,410,485(+) AGGAT(C/T)ATTCC utr-variant-3-prime
rs10502185 -- 114,410,693(+) TAGTT(C/G)TCATA downstream-variant-500B
rs1051885 -- 114,400,138(-) CGAGA(A/G)CCGTC upstream-variant-2KB, reference, missense
rs1051890 -- 114,400,097(-) AACCA(A/G)ATGGC upstream-variant-2KB, reference, missense
rs1054777 -- 114,410,181(+) CAGTT(C/T)CTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RBM7 Gene

Variant ID Type Subtype PubMed ID
nsv983063 CNV duplication 23825009

Variation tolerance for RBM7 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM7 Gene

Disorders for RBM7 Gene

Relevant External Links for RBM7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM7

No disorders were found for RBM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM7 Gene

Publications for RBM7 Gene

  1. RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3'-end extended forms of snRNAs. (PMID: 25852104) Hrossova D. … Vanacova S. (Nucleic Acids Res. 2015) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors. (PMID: 12634307) Guo T.B. … Salameh W.A. (J. Androl. 2003) 3 4 64
  5. p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex. (PMID: 25525152) Tiedje C. … Gaestel M. (RNA 2015) 3 64

Products for RBM7 Gene

Sources for RBM7 Gene

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