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Aliases for RBM7 Gene

Aliases for RBM7 Gene

  • RNA Binding Motif Protein 7 2 3 5
  • RNA-Binding Motif Protein 7 4

External Ids for RBM7 Gene

Previous GeneCards Identifiers for RBM7 Gene

  • GC11P116624
  • GC11P115783
  • GC11P114305
  • GC11P113808
  • GC11P113776
  • GC11P110199
  • GC11P114270

Summaries for RBM7 Gene

GeneCards Summary for RBM7 Gene

RBM7 (RNA Binding Motif Protein 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ENSG00000255663.

UniProtKB/Swiss-Prot for RBM7 Gene

  • Possible involved in germ cell RNA processing and meiosis.

Gene Wiki entry for RBM7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM7 Gene

Genomics for RBM7 Gene

Regulatory Elements for RBM7 Gene

Enhancers for RBM7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RBM7 on UCSC Golden Path with GeneCards custom track

Promoters for RBM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM7 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM7 Gene

Chromosome:
11
Start:
114,400,030 bp from pter
End:
114,414,203 bp from pter
Size:
14,174 bases
Orientation:
Plus strand

Genomic View for RBM7 Gene

Genes around RBM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM7 Gene

Proteins for RBM7 Gene

  • Protein details for RBM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y580-RBM7_HUMAN
    Recommended name:
    RNA-binding protein 7
    Protein Accession:
    Q9Y580
    Secondary Accessions:
    • B2R6K8
    • Q9NUT4

    Protein attributes for RBM7 Gene

    Size:
    266 amino acids
    Molecular mass:
    30504 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBM7 Gene

neXtProt entry for RBM7 Gene

Proteomics data for RBM7 Gene at MOPED

Post-translational modifications for RBM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM7 Gene

Domains & Families for RBM7 Gene

Gene Families for RBM7 Gene

Protein Domains for RBM7 Gene

Suggested Antigen Peptide Sequences for RBM7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y580

UniProtKB/Swiss-Prot:

RBM7_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBM7: view

Function for RBM7 Gene

Molecular function for RBM7 Gene

UniProtKB/Swiss-Prot Function:
Possible involved in germ cell RNA processing and meiosis.

Gene Ontology (GO) - Molecular Function for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM7: view
genes like me logo Genes that share phenotypes with RBM7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM7 Gene

Localization for RBM7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM7 Gene COMPARTMENTS Subcellular localization image for RBM7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM7 Gene

Pathways & Interactions for RBM7 Gene

SuperPathways for RBM7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM7 Gene

Drugs & Compounds for RBM7 Gene

No Compound Related Data Available

Transcripts for RBM7 Gene

Unigene Clusters for RBM7 Gene

RNA binding motif protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for RBM7 Gene

GeneLoc Exon Structure for
RBM7
ECgene alternative splicing isoforms for
RBM7

Expression for RBM7 Gene

mRNA expression in normal human tissues for RBM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM7 Gene

This gene is overexpressed in Lung (39.4) and Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM7 Gene



SOURCE GeneReport for Unigene cluster for RBM7 Gene Hs.7527

mRNA Expression by UniProt/SwissProt for RBM7 Gene

Q9Y580-RBM7_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with RBM7: view

Protein tissue co-expression partners for RBM7 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for RBM7 Gene

Orthologs for RBM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBM7 35
  • 90.46 (n)
  • 89.31 (a)
RBM7 36
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RBM7 35
  • 89.06 (n)
  • 88.17 (a)
-- 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rbm7 35
  • 85.16 (n)
  • 83.77 (a)
Rbm7 16
Rbm7 36
  • 84 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RBM7 35
  • 99.25 (n)
  • 99.25 (a)
RBM7 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rbm7 35
  • 83.42 (n)
  • 78.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves RBM7 35
  • 64.57 (n)
  • 61.42 (a)
RBM7 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735152 35
  • 69.86 (n)
  • 68.49 (a)
Str.10735 35
African clawed frog
(Xenopus laevis)
Amphibia rbm7-prov 35
zebrafish
(Danio rerio)
Actinopterygii wufa03f03 35
zgc:77304 35
  • 55.04 (n)
  • 49.36 (a)
RBM7 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11454 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y37D8A.21 36
  • 23 (a)
OneToMany
Species with no ortholog for RBM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM7 Gene

ENSEMBL:
Gene Tree for RBM7 (if available)
TreeFam:
Gene Tree for RBM7 (if available)

Paralogs for RBM7 Gene

Paralogs for RBM7 Gene

Pseudogenes.org Pseudogenes for RBM7 Gene

genes like me logo Genes that share paralogs with RBM7: view

Variants for RBM7 Gene

Sequence variations from dbSNP and Humsavar for RBM7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs536179 -- 114,404,351(+) TAGAA(A/G)GTGGA intron-variant
rs648642 -- 114,409,053(-) TGTAC(A/C)AAAGA utr-variant-3-prime
rs678207 -- 114,407,082(-) AAGGG(A/G)GAGAT intron-variant
rs11543050 -- 114,407,658(+) AACAG(A/C/T)GTTAC reference, missense
rs61268847 -- 114,404,701(+) AAAAA(-/A/AA)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM7 Gene

Variant ID Type Subtype PubMed ID
nsv898396 CNV Gain 21882294

Variation tolerance for RBM7 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RBM7 Gene

Disorders for RBM7 Gene

Relevant External Links for RBM7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM7

No disorders were found for RBM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM7 Gene

Publications for RBM7 Gene

  1. RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3'-end extended forms of snRNAs. (PMID: 25852104) Hrossova D. … Vanacova S. (Nucleic Acids Res. 2015) 2 3 67
  2. p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex. (PMID: 25525152) Tiedje C. … Gaestel M. (RNA 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RBM7 Gene

Sources for RBM7 Gene

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