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Aliases for RBM7 Gene

Aliases for RBM7 Gene

  • RNA Binding Motif Protein 7 2 3 5
  • RNA-Binding Motif Protein 7 4

External Ids for RBM7 Gene

Previous GeneCards Identifiers for RBM7 Gene

  • GC11P116624
  • GC11P115783
  • GC11P114305
  • GC11P113808
  • GC11P113776
  • GC11P110199
  • GC11P114270

Summaries for RBM7 Gene

GeneCards Summary for RBM7 Gene

RBM7 (RNA Binding Motif Protein 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ENSG00000255663.

UniProtKB/Swiss-Prot for RBM7 Gene

  • Possible involved in germ cell RNA processing and meiosis.

Gene Wiki entry for RBM7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM7 Gene

Genomics for RBM7 Gene

Regulatory Elements for RBM7 Gene

Enhancers for RBM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G114398 1.4 ENCODE dbSUPER 27.3 +0.4 416 3.8 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RBM7 ZW10 C11orf71
GH11G114214 1.6 FANTOM5 ENCODE dbSUPER 10.9 -183.4 -183405 3.6 PKNOX1 ATF1 CREB3L1 ARNT E2F7 TCF12 ZNF766 CBX5 GATA2 KDM4B NNMT RBM7 ZBTB16 PIR38575 PIR57549
GH11G114288 1.6 Ensembl ENCODE dbSUPER 10.5 -104.6 -104576 13.1 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 SP3 NNMT LOC101928940 RBM7 ENSG00000255663 C11orf71 ENSG00000270179 ZW10 GC11P114306 GC11M114263
GH11G114365 0.8 Ensembl ENCODE 16.5 -33.2 -33180 2.8 JUND SMARCA4 POLR2A JUN RBM7 ENSG00000255663 C11orf71 ENSG00000270179 LOC101928940 ENSG00000256947
GH11G114348 1.1 Ensembl ENCODE 11.2 -51.2 -51215 1.5 TBL1XR1 RAD21 TCF12 GATA2 FOS ZNF654 ZBTB2 JUNB ELF4 REST REXO2 LOC101928940 C11orf71 ENSG00000255663 RBM7 ENSG00000256947 GC11P114340
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM7 on UCSC Golden Path with GeneCards custom track

Promoters for RBM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RBM7 Gene

114,400,030 bp from pter
114,414,203 bp from pter
14,174 bases
Plus strand

Genomic View for RBM7 Gene

Genes around RBM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM7 Gene

Proteins for RBM7 Gene

  • Protein details for RBM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 7
    Protein Accession:
    Secondary Accessions:
    • B2R6K8
    • Q9NUT4

    Protein attributes for RBM7 Gene

    266 amino acids
    Molecular mass:
    30504 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBM7 Gene

neXtProt entry for RBM7 Gene

Post-translational modifications for RBM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM7 Gene

Domains & Families for RBM7 Gene

Suggested Antigen Peptide Sequences for RBM7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM7: view

No data available for UniProtKB/Swiss-Prot for RBM7 Gene

Function for RBM7 Gene

Molecular function for RBM7 Gene

UniProtKB/Swiss-Prot Function:
Possible involved in germ cell RNA processing and meiosis.

Gene Ontology (GO) - Molecular Function for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003727 single-stranded RNA binding IBA --
GO:0005515 protein binding IPI 16263084
genes like me logo Genes that share ontologies with RBM7: view
genes like me logo Genes that share phenotypes with RBM7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM7 Gene

Localization for RBM7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM7 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2

Gene Ontology (GO) - Cellular Components for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA 16263084
genes like me logo Genes that share ontologies with RBM7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RBM7 Gene

Pathways & Interactions for RBM7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with RBM7: view

No data available for Pathways by source and SIGNOR curated interactions for RBM7 Gene

Drugs & Compounds for RBM7 Gene

No Compound Related Data Available

Transcripts for RBM7 Gene

Unigene Clusters for RBM7 Gene

RNA binding motif protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3: -
SP4: -

Relevant External Links for RBM7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM7 Gene

This gene is overexpressed in Lung (39.4) and Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM7 Gene

Protein tissue co-expression partners for RBM7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM7 Gene:


SOURCE GeneReport for Unigene cluster for RBM7 Gene:


mRNA Expression by UniProt/SwissProt for RBM7 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RBM7 Gene

  • Nervous system(4.5)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RBM7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM7 Gene

Orthologs for RBM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM7 34 35
  • 99.25 (n)
(Bos Taurus)
Mammalia RBM7 34 35
  • 90.46 (n)
(Canis familiaris)
Mammalia -- 35
  • 90 (a)
RBM7 34
  • 89.06 (n)
(Mus musculus)
Mammalia Rbm7 34 16 35
  • 85.16 (n)
(Rattus norvegicus)
Mammalia Rbm7 34
  • 83.42 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
(Gallus gallus)
Aves RBM7 34 35
  • 64.57 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735152 34
  • 69.86 (n)
Str.10735 34
African clawed frog
(Xenopus laevis)
Amphibia rbm7-prov 34
(Danio rerio)
Actinopterygii zgc:77304 34
  • 55.04 (n)
RBM7 35
  • 43 (a)
wufa03f03 34
fruit fly
(Drosophila melanogaster)
Insecta CG11454 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea Y37D8A.21 35
  • 23 (a)
Species where no ortholog for RBM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM7 Gene

Gene Tree for RBM7 (if available)
Gene Tree for RBM7 (if available)

Paralogs for RBM7 Gene

Paralogs for RBM7 Gene Pseudogenes for RBM7 Gene

genes like me logo Genes that share paralogs with RBM7: view

Variants for RBM7 Gene

Sequence variations from dbSNP and Humsavar for RBM7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000122162 -- 114,400,453(+) TAACT(A/G)AGCCT upstream-variant-2KB, utr-variant-5-prime
rs1000142686 -- 114,399,283(+) ACAGT(A/G)AGTAG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000345090 -- 114,406,788(+) GCACT(C/T)TGGGA intron-variant
rs1000352717 -- 114,405,129(+) ATTCT(A/T)TTCAT intron-variant
rs1000794307 -- 114,401,256(+) TTAGT(A/G)TTGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RBM7 Gene

Variant ID Type Subtype PubMed ID
nsv983063 CNV duplication 23825009

Variation tolerance for RBM7 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM7 Gene

Disorders for RBM7 Gene

Relevant External Links for RBM7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RBM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM7 Gene

Publications for RBM7 Gene

  1. RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3'-end extended forms of snRNAs. (PMID: 25852104) Hrossova D. … Vanacova S. (Nucleic Acids Res. 2015) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors. (PMID: 12634307) Guo T.B. … Salameh W.A. (J. Androl. 2003) 3 4 64
  5. RRM domain of human RBM7: purification, crystallization and structure determination. (PMID: 27139832) Sofos N. … Brodersen D.E. (Acta Crystallogr F Struct Biol Commun 2016) 3 64

Products for RBM7 Gene

Sources for RBM7 Gene

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