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Aliases for RBM6 Gene

Aliases for RBM6 Gene

  • RNA Binding Motif Protein 6 2 3
  • DEF3 3 4 6
  • Lung Cancer Antigen NY-LU-12 3 4
  • RNA-Binding Motif Protein 6 3 4
  • RNA-Binding Protein DEF-3 3 4
  • Lung Cancer Protooncogene 11 3
  • RNA-Binding Protein 6 3
  • Protein G16 4
  • NY-LU-12 3
  • HLC-11 3
  • DEF-3 3
  • 3G2 3
  • G16 3

External Ids for RBM6 Gene

Previous GeneCards Identifiers for RBM6 Gene

  • GC03M049873
  • GC03M050042
  • GC03P049831
  • GC03P049936

Summaries for RBM6 Gene

GeneCards Summary for RBM6 Gene

RBM6 (RNA Binding Motif Protein 6) is a Protein Coding gene. Diseases associated with RBM6 include lung cancer. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM10.

UniProtKB/Swiss-Prot for RBM6 Gene

  • Specifically binds poly(G) RNA homopolymers in vitro

Gene Wiki entry for RBM6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM6 Gene

Genomics for RBM6 Gene

Regulatory Elements for RBM6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBM6 Gene

Start:
49,940,007 bp from pter
End:
50,100,045 bp from pter
Size:
160,039 bases
Orientation:
Plus strand

Genomic View for RBM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM6 Gene

Proteins for RBM6 Gene

  • Protein details for RBM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78332-RBM6_HUMAN
    Recommended name:
    RNA-binding protein 6
    Protein Accession:
    P78332
    Secondary Accessions:
    • B4E0G6
    • O60549
    • O75524
    • Q86SS3

    Protein attributes for RBM6 Gene

    Size:
    1123 amino acids
    Molecular mass:
    128644 Da
    Quaternary structure:
    • May interact with FAM168B

    Alternative splice isoforms for RBM6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM6 Gene

Proteomics data for RBM6 Gene at MOPED

Post-translational modifications for RBM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM6 Gene

Domains for RBM6 Gene

Gene Families for RBM6 Gene

HGNC:
  • GPATCH :G patch domain containing
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

P78332

UniProtKB/Swiss-Prot:

RBM6_HUMAN :
  • P78332
Domain:
  • Contains 1 G-patch domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBM6: view

Function for RBM6 Gene

Molecular function for RBM6 Gene

GENATLAS Biochemistry: RNA binding protein 6,including two alternatively spliced long and short (truncated) isoforms with some homology with DXS8237E,located in a region duplicated for the Xp11.3-p11.23 region containing UBE1 and DXS8237E
UniProtKB/Swiss-Prot Function: Specifically binds poly(G) RNA homopolymers in vitro

Gene Ontology (GO) - Molecular Function for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding TAS 10352938
GO:0003723 RNA binding TAS 10352938
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBM6: view

Animal Model Products

CRISPR Products

miRNA for RBM6 Gene

miRTarBase miRNAs that target RBM6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM6 Gene

Localization for RBM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM6 Gene COMPARTMENTS Subcellular localization image for RBM6 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBM6: view

Pathways for RBM6 Gene

SuperPathways for RBM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 10352938
genes like me logo Genes that share ontologies with RBM6: view

No data available for Pathways by source for RBM6 Gene

Transcripts for RBM6 Gene

Unigene Clusters for RBM6 Gene

RNA binding motif protein 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RBM6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - -
SP6:
SP7: - - - - - - - - - - - -
SP8: - -
SP9: - -
SP10:
SP11: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RBM6 Gene

GeneLoc Exon Structure for
RBM6
ECgene alternative splicing isoforms for
RBM6

Expression for RBM6 Gene

mRNA expression in normal human tissues for RBM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RBM6 Gene

SOURCE GeneReport for Unigene cluster for RBM6 Gene Hs.696735

mRNA Expression by UniProt/SwissProt for RBM6 Gene

P78332-RBM6_HUMAN
Tissue specificity: Ubiquitous in adults
genes like me logo Genes that share expressions with RBM6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RBM6 Gene

Orthologs for RBM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM6 35
  • 99.84 (n)
  • 99.65 (a)
RBM6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM6 35
  • 92.08 (n)
  • 91.07 (a)
RBM6 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM6 35
  • 92.69 (n)
  • 92.51 (a)
RBM6 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm6 35
  • 89.86 (n)
  • 89.45 (a)
Rbm6 16
Rbm6 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM6 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM6 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm6 35
  • 89.37 (n)
  • 89.9 (a)
chicken
(Gallus gallus)
Aves RBM6 35
  • 68.47 (n)
  • 64.96 (a)
RBM6 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM6 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498473 35
  • 49.7 (n)
  • 37.88 (a)
zebrafish
(Danio rerio)
Actinopterygii rbm6 36
  • 15 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4887 36
  • 17 (a)
ManyToMany
CG4896 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T08B2.5 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for RBM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM6 Gene

ENSEMBL:
Gene Tree for RBM6 (if available)
TreeFam:
Gene Tree for RBM6 (if available)

Paralogs for RBM6 Gene

Paralogs for RBM6 Gene

genes like me logo Genes that share paralogs with RBM6: view

Variants for RBM6 Gene

Sequence variations from dbSNP and Humsavar for RBM6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7061 -- 50,077,082(+) ACTTA(C/T)CGAGA reference, synonymous-codon
rs1058874 -- 50,066,431(+) CTTGT(C/T)TGCTT reference, synonymous-codon
rs1802394 -- 50,068,718(+) GATAA(A/C)ACAGT reference, missense
rs1802395 -- 50,075,254(+) AGGCT(C/G)TGTCC missense, reference
rs1802396 -- 50,062,012(+) GAGAT(C/T)AAGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RBM6 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876767 CNV Loss 21882294
nsv834689 CNV Loss 17160897
esv1004636 CNV Deletion 20482838
esv2659342 CNV Deletion 23128226
nsv822078 CNV Loss 20364138
nsv820223 CNV Loss 19587683
esv2725257 CNV Deletion 23290073
esv1163072 CNV Insertion 17803354
nsv834690 CNV Loss 17160897
nsv515986 CNV Loss 19592680

Relevant External Links for RBM6 Gene

HapMap Linkage Disequilibrium report
RBM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM6 Gene

Disorders for RBM6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RBM6 Gene including...

Search for RBM6 Gene in MalaCards »

Relevant External Links for RBM6

Genetic Association Database (GAD)
RBM6
Human Genome Epidemiology (HuGE) Navigator
RBM6
genes like me logo Genes that share disorders with RBM6: view

No data available for UniProtKB/Swiss-Prot for RBM6 Gene

Publications for RBM6 Gene

  1. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. (PMID: 9500467) Gure A.O. … Chen Y.-T. (Cancer Res. 1998) 3 4 23
  2. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. (PMID: 10352938) Timmer T. … Buys C.H.C.M. (Eur. J. Hum. Genet. 1999) 2 3 4
  3. DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC. (PMID: 10353602) Drabkin H.A. … Sablitzky F. (Oncogene 1999) 3 4
  4. RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours. (PMID: 17908320) Wang K. … Sutherland L.C. (BMC Genomics 2007) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RBM6 Gene

Sources for RBM6 Gene

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