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Aliases for RBM6 Gene

Aliases for RBM6 Gene

  • RNA Binding Motif Protein 6 2 3 5
  • Lung Cancer Antigen NY-LU-12 3 4
  • RNA-Binding Motif Protein 6 3 4
  • RNA-Binding Protein DEF-3 3 4
  • DEF3 3 4
  • Lung Cancer Protooncogene 11 3
  • RNA-Binding Protein 6 3
  • Protein G16 4
  • NY-LU-12 3
  • HLC-11 3
  • DEF-3 3
  • 3G2 3
  • G16 3

External Ids for RBM6 Gene

Previous GeneCards Identifiers for RBM6 Gene

  • GC03M049873
  • GC03M050042
  • GC03P049831
  • GC03P049936

Summaries for RBM6 Gene

GeneCards Summary for RBM6 Gene

RBM6 (RNA Binding Motif Protein 6) is a Protein Coding gene. Diseases associated with RBM6 include Lung Cancer. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM10.

UniProtKB/Swiss-Prot for RBM6 Gene

  • Specifically binds poly(G) RNA homopolymers in vitro.

Gene Wiki entry for RBM6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM6 Gene

Genomics for RBM6 Gene

Regulatory Elements for RBM6 Gene

Enhancers for RBM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RBM6 on UCSC Golden Path with GeneCards custom track

Promoters for RBM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RBM6 Gene

49,940,007 bp from pter
50,100,045 bp from pter
160,039 bases
Plus strand

Genomic View for RBM6 Gene

Genes around RBM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM6 Gene

Proteins for RBM6 Gene

  • Protein details for RBM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • B4E0G6
    • O60549
    • O75524
    • Q86SS3

    Protein attributes for RBM6 Gene

    1123 amino acids
    Molecular mass:
    128644 Da
    Quaternary structure:
    • May interact with FAM168B.

    Alternative splice isoforms for RBM6 Gene


neXtProt entry for RBM6 Gene

Post-translational modifications for RBM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM6 Gene

Domains & Families for RBM6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 G-patch domain.
  • Contains 1 G-patch domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBM6: view

Function for RBM6 Gene

Molecular function for RBM6 Gene

GENATLAS Biochemistry:
RNA binding protein 6,including two alternatively spliced long and short (truncated) isoforms with some homology with DXS8237E,located in a region duplicated for the Xp11.3-p11.23 region containing UBE1 and DXS8237E
UniProtKB/Swiss-Prot Function:
Specifically binds poly(G) RNA homopolymers in vitro.

Gene Ontology (GO) - Molecular Function for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding TAS 10352938
GO:0003723 RNA binding TAS 10352938
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM6: view

Phenotypes for RBM6 Gene

GenomeRNAi human phenotypes for RBM6:
genes like me logo Genes that share phenotypes with RBM6: view

Animal Model Products

CRISPR Products

miRNA for RBM6 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM6 Gene

Localization for RBM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM6 Gene

Subcellular locations from

Jensen Localization Image for RBM6 Gene COMPARTMENTS Subcellular localization image for RBM6 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBM6: view

Pathways & Interactions for RBM6 Gene

SuperPathways for RBM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 10352938
genes like me logo Genes that share ontologies with RBM6: view

No data available for Pathways by source and SIGNOR curated interactions for RBM6 Gene

Drugs & Compounds for RBM6 Gene

No Compound Related Data Available

Transcripts for RBM6 Gene

Unigene Clusters for RBM6 Gene

RNA binding motif protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - -
SP7: - - - - - - - - - - - -
SP8: - -
SP9: - -
SP11: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -

Relevant External Links for RBM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM6 Gene

mRNA expression in normal human tissues for RBM6 Gene

Protein differential expression in normal tissues from HIPED for RBM6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.5), Placenta (15.2), and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM6 Gene

Protein tissue co-expression partners for RBM6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM6 Gene:


SOURCE GeneReport for Unigene cluster for RBM6 Gene:


mRNA Expression by UniProt/SwissProt for RBM6 Gene:

Tissue specificity: Ubiquitous in adults.
genes like me logo Genes that share expression patterns with RBM6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBM6 Gene

Orthologs for RBM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBM6 34
  • 92.08 (n)
  • 91.07 (a)
RBM6 35
  • 91 (a)
(Canis familiaris)
Mammalia RBM6 34
  • 92.69 (n)
  • 92.51 (a)
RBM6 35
  • 92 (a)
(Mus musculus)
Mammalia Rbm6 34
  • 89.86 (n)
  • 89.45 (a)
Rbm6 16
Rbm6 35
  • 89 (a)
(Pan troglodytes)
Mammalia RBM6 34
  • 99.84 (n)
  • 99.65 (a)
RBM6 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Rbm6 34
  • 89.37 (n)
  • 89.9 (a)
(Monodelphis domestica)
Mammalia RBM6 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RBM6 35
  • 72 (a)
(Gallus gallus)
Aves RBM6 34
  • 68.47 (n)
  • 64.96 (a)
RBM6 35
  • 54 (a)
(Anolis carolinensis)
Reptilia RBM6 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498473 34
  • 49.7 (n)
  • 37.88 (a)
(Danio rerio)
Actinopterygii rbm6 35
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4887 35
  • 17 (a)
CG4896 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea T08B2.5 35
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
Species where no ortholog for RBM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM6 Gene

Gene Tree for RBM6 (if available)
Gene Tree for RBM6 (if available)

Paralogs for RBM6 Gene

Paralogs for RBM6 Gene

genes like me logo Genes that share paralogs with RBM6: view

Variants for RBM6 Gene

Sequence variations from dbSNP and Humsavar for RBM6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs61731329 A non-small cell lung cancer cell line 49,968,483(+) TGAGT(C/T)TCCAG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs34707170 - 50,059,680(+) ACAGA(A/C/G)CCTTG nc-transcript-variant, reference, missense
rs7061 -- 50,077,082(+) ACTTA(C/T)CGAGA nc-transcript-variant, reference, synonymous-codon
rs1058874 -- 50,066,431(+) CTTGT(C/T)TGCTT nc-transcript-variant, reference, synonymous-codon
rs4608691 -- 49,974,148(-) AGGCC(A/G)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM6 Gene

Variant ID Type Subtype PubMed ID
esv1004636 CNV deletion 20482838
esv1163072 CNV insertion 17803354
esv2659342 CNV deletion 23128226
esv2725257 CNV deletion 23290073
esv3596134 CNV loss 21293372
esv3596135 CNV loss 21293372
nsv1012903 CNV gain 25217958
nsv1109512 CNV deletion 24896259
nsv1116989 CNV deletion 24896259
nsv515986 CNV loss 19592680
nsv590249 CNV loss 21841781
nsv820223 CNV loss 19587683
nsv822078 CNV loss 20364138
nsv834688 CNV loss 17160897
nsv834689 CNV loss 17160897
nsv834690 CNV loss 17160897

Variation tolerance for RBM6 Gene

Residual Variation Intolerance Score: 9.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM6 Gene

Disorders for RBM6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBM6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search RBM6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBM6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RBM6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM6 Gene

Publications for RBM6 Gene

  1. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. (PMID: 10352938) Timmer T. … Buys C.H.C.M. (Eur. J. Hum. Genet. 1999) 2 3 4 65
  2. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. (PMID: 9500467) Gure A.O. … Chen Y.-T. (Cancer Res. 1998) 3 4 22 65
  3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 46 65
  4. RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours. (PMID: 17908320) Wang K. … Sutherland L.C. (BMC Genomics 2007) 3 22 65
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65

Products for RBM6 Gene

Sources for RBM6 Gene

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