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Aliases for RBM6 Gene

Aliases for RBM6 Gene

  • RNA Binding Motif Protein 6 2 3 5
  • Lung Cancer Antigen NY-LU-12 3 4
  • RNA-Binding Motif Protein 6 3 4
  • RNA-Binding Protein DEF-3 3 4
  • DEF3 3 4
  • Lung Cancer Protooncogene 11 3
  • Protein G16 4
  • NY-LU-12 3
  • HLC-11 3
  • DEF-3 3
  • 3G2 3
  • G16 3

External Ids for RBM6 Gene

Previous GeneCards Identifiers for RBM6 Gene

  • GC03M049873
  • GC03M050042
  • GC03P049831
  • GC03P049936

Summaries for RBM6 Gene

GeneCards Summary for RBM6 Gene

RBM6 (RNA Binding Motif Protein 6) is a Protein Coding gene. Diseases associated with RBM6 include Lung Cancer. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM5.

UniProtKB/Swiss-Prot for RBM6 Gene

  • Specifically binds poly(G) RNA homopolymers in vitro.

Gene Wiki entry for RBM6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM6 Gene

Genomics for RBM6 Gene

Regulatory Elements for RBM6 Gene

Enhancers for RBM6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RBM6 on UCSC Golden Path with GeneCards custom track

Promoters for RBM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM6 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM6 Gene

49,940,007 bp from pter
50,100,045 bp from pter
160,039 bases
Plus strand

Genomic View for RBM6 Gene

Genes around RBM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM6 Gene

Proteins for RBM6 Gene

  • Protein details for RBM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • B4E0G6
    • O60549
    • O75524
    • Q86SS3

    Protein attributes for RBM6 Gene

    1123 amino acids
    Molecular mass:
    128644 Da
    Quaternary structure:
    • May interact with FAM168B.

    Alternative splice isoforms for RBM6 Gene


neXtProt entry for RBM6 Gene

Proteomics data for RBM6 Gene at MOPED

Post-translational modifications for RBM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM6 Gene

Domains & Families for RBM6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 G-patch domain.
  • Contains 1 G-patch domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBM6: view

Function for RBM6 Gene

Molecular function for RBM6 Gene

GENATLAS Biochemistry:
RNA binding protein 6,including two alternatively spliced long and short (truncated) isoforms with some homology with DXS8237E,located in a region duplicated for the Xp11.3-p11.23 region containing UBE1 and DXS8237E
UniProtKB/Swiss-Prot Function:
Specifically binds poly(G) RNA homopolymers in vitro.

Gene Ontology (GO) - Molecular Function for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 10352938
GO:0003723 RNA binding IEA,TAS 10352938
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM6: view

Phenotypes for RBM6 Gene

GenomeRNAi human phenotypes for RBM6:
genes like me logo Genes that share phenotypes with RBM6: view

Animal Model Products

miRNA for RBM6 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM6 Gene

Localization for RBM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM6 Gene

Subcellular locations from

Jensen Localization Image for RBM6 Gene COMPARTMENTS Subcellular localization image for RBM6 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for RBM6 Gene

Pathways & Interactions for RBM6 Gene

SuperPathways for RBM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM6 Gene


No data available for Pathways by source and SIGNOR curated interactions for RBM6 Gene

Drugs & Compounds for RBM6 Gene

No Compound Related Data Available

Transcripts for RBM6 Gene

Unigene Clusters for RBM6 Gene

RNA binding motif protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - -
SP7: - - - - - - - - - - - -
SP8: - -
SP9: - -
SP11: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -

Relevant External Links for RBM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM6 Gene

mRNA expression in normal human tissues for RBM6 Gene

Protein differential expression in normal tissues from HIPED for RBM6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.5), Placenta (15.2), and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM6 Gene

SOURCE GeneReport for Unigene cluster for RBM6 Gene Hs.696735

mRNA Expression by UniProt/SwissProt for RBM6 Gene

Tissue specificity: Ubiquitous in adults.
genes like me logo Genes that share expression patterns with RBM6: view

Protein tissue co-expression partners for RBM6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBM6 Gene

Orthologs for RBM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBM6 35
  • 92.08 (n)
  • 91.07 (a)
RBM6 36
  • 91 (a)
(Canis familiaris)
Mammalia RBM6 35
  • 92.69 (n)
  • 92.51 (a)
RBM6 36
  • 92 (a)
(Mus musculus)
Mammalia Rbm6 35
  • 89.86 (n)
  • 89.45 (a)
Rbm6 16
Rbm6 36
  • 89 (a)
(Pan troglodytes)
Mammalia RBM6 35
  • 99.84 (n)
  • 99.65 (a)
RBM6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rbm6 35
  • 89.37 (n)
  • 89.9 (a)
(Monodelphis domestica)
Mammalia RBM6 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RBM6 36
  • 72 (a)
(Gallus gallus)
Aves RBM6 35
  • 68.47 (n)
  • 64.96 (a)
RBM6 36
  • 54 (a)
(Anolis carolinensis)
Reptilia RBM6 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498473 35
  • 49.7 (n)
  • 37.88 (a)
(Danio rerio)
Actinopterygii rbm6 36
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4887 36
  • 17 (a)
CG4896 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea T08B2.5 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for RBM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM6 Gene

Gene Tree for RBM6 (if available)
Gene Tree for RBM6 (if available)

Paralogs for RBM6 Gene

Paralogs for RBM6 Gene

genes like me logo Genes that share paralogs with RBM6: view

Variants for RBM6 Gene

Sequence variations from dbSNP and Humsavar for RBM6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs61731329 A non-small cell lung cancer cell line 49,968,483(+) TGAGT(C/T)TCCAG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs34707170 - 50,059,680(+) ACAGA(A/C/G)CCTTG nc-transcript-variant, reference, missense
rs7061 -- 50,077,082(+) ACTTA(C/T)CGAGA nc-transcript-variant, reference, synonymous-codon
rs1058874 -- 50,066,431(+) CTTGT(C/T)TGCTT nc-transcript-variant, reference, synonymous-codon
rs2352969 -- 49,966,199(+) AATCA(C/G)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM6 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876767 CNV Loss 21882294
nsv834689 CNV Loss 17160897
esv1004636 CNV Deletion 20482838
esv2659342 CNV Deletion 23128226
nsv822078 CNV Loss 20364138
nsv820223 CNV Loss 19587683
esv2725257 CNV Deletion 23290073
esv1163072 CNV Insertion 17803354
nsv834690 CNV Loss 17160897
nsv515986 CNV Loss 19592680

Variation tolerance for RBM6 Gene

Residual Variation Intolerance Score: 9.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RBM6 Gene

Disorders for RBM6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBM6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search RBM6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBM6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RBM6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM6 Gene

Publications for RBM6 Gene

  1. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. (PMID: 10352938) Timmer T. … Buys C.H.C.M. (Eur. J. Hum. Genet. 1999) 2 3 4 67
  2. RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours. (PMID: 17908320) Wang K. … Sutherland L.C. (BMC Genomics 2007) 3 23
  3. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. (PMID: 9500467) Gure A.O. … Chen Y.-T. (Cancer Res. 1998) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RBM6 Gene

Sources for RBM6 Gene