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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RBM5 Gene

protein-coding GIFtS: 60
GCID: GC03P050101

RNA binding motif protein 5

Explore 8 diseases affiliated with
RBM5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RNA Binding Motif Protein 5¹ ²		H37¹
LUCA15¹ ² ⁵		G15²
Putative Tumor Suppressor LUCA15² ³		RNA-Binding Protein 5²
Renal Carcinoma Antigen NY-REN-9² ³		Protein G15³
RMB5² ⁵		RNA-Binding Motif Protein 5³

External Ids:	HGNC: 9902¹	Entrez Gene: 10181²	Ensembl: ENSG00000003756⁷	OMIM: 606884⁵	UniProtKB: P52756³

ORGUL members:
	NONCODE:n410156

Export aliases for RBM5 gene to outside databases

Previous GC identifers: GC03M049830 GC03M050000 GC03P049980 GC03P050085

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBM5:

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the

spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through

pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the

tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of

several malignancies including lung cancer. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756

Function: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate

splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both

positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this

process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a

soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby

producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis

Gene Wiki entry for RBM5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RBM5 gene promoter:
Spz1 AML1a NRSF form 1 HSF1 (long) Pax-2a NRSF form 2 CREB SRY deltaCREB HSF1short
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): RBM5 promoter sequence

Search SABiosciences Chromatin IP Primers for RBM5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

RBM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM5 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P050101: view genomic region (about GC identifiers)

Start:	50,126,341 bp from pter	End:	50,156,454 bp from pter
Size:	30,114 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756 (See protein sequence)

Recommended Name: RNA-binding protein 5

Size: 815 amino acids; 92154 Da

Subunit: Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the

spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the

heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1,

PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect

Subcellular location: Nucleus

Sequence caution: Sequence=BAG59728.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG59871.1;

Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG63975.1; Type=Erroneous translation; Note=Wrong

choice of CDS;

3 PDB 3D structures from and Proteopedia for RBM5:

2LK0 (3D)

2LK1 (3D)

2LKZ (3D)

Secondary accessions: B2RA45 B4DM16 B4DMF9 B4DZ63 Q93021 Q9BU14 Q9HDA6 Q9UKY8 Q9UL24

Alternative splicing: 5 isoforms: P52756-1 P52756-2 P52756-3 P52756-4 P52756-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBM5: NX_P52756

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P52756

RBM5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005769.1

ENSEMBL proteins:

ENSP00000343054 ENSP00000419534 ENSP00000384872 ENSP00000390711 ENSP00000414218

ENSP00000394622 ENSP00000406119 ENSP00000378603

Reactome Protein details: P52756
Human Recombinant Protein Products:

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	Uscn Proteins for RBM5

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005681	spliceosomal complex	TAS	18951082
GO:0005730	NOT nucleolus	IDA	--

RBM5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RBM5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RBM5 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR012677 Nucleotide-bd_a/b_plait

IPR015880 Znf_C2H2-like

IPR000467 G_patch_dom

IPR001876 Znf_RanBP2

IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry P52756

ProtoNet protein and cluster: P52756

3 Blocks protein families:

IPB000467 D111/G-patch domain

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB001876 Zn-finger

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756

Similarity: Belongs to the RBM5/RBM10 family

Similarity: Contains 1 C2H2-type zinc finger

Similarity: Contains 1 G-patch domain

Similarity: Contains 1 RanBP2-type zinc finger

Similarity: Contains 2 RRM (RNA recognition motif) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756

Function: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate

splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both

positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this

process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a

soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby

producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis

Genatlas biochemistry entry for RBM5:

RNA binding protein 5 in the TSG3B region,homolog with DXS8237E,located in a region duplicated for the Xp11.3-p11.23

region containing UBE1 and DXS8237E

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		hsa-miR-323-3p hsa-miR-300 hsa-miR-196a* hsa-miR-381 hsa-miR-708* hsa-miR-3647-3p hsa-miR-151-3p hsa-miR-182

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM5

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	TAS	10352938
GO:0003723	RNA binding	TAS	10352938
GO:0003729	mRNA binding	IDA	18840686
GO:0005515	protein binding	IPI	18951082

RBM5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RBM5:

Increased S DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for RBM5

mRNA processing

5 Reactome Pathways for RBM5

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

RBM5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RBM5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/118 Interacting proteins for RBM5 (P52756^{2, 3} ENSP00000343054⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 118)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DHX15	O43143², ENSP00000336741⁴	MINT-8328618 MINT-8328286 MINT-8328168 MINT-8328357 MINT-8328000 MINT-8328264 MINT-8328306 MINT-8328195 MINT-8328330 MINT-8332218 MINT-8328060 MINT-8328016 MINT-8328178 MINT-8334010 STRING: ENSP00000336741
GAPDH	P04406²^,³, ENSP00000229239⁴	MINT-8256404 I2D: score=2 STRING: ENSP00000229239
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5206016 I2D: score=1 STRING: ENSP00000221494
LRIF1	Q5T3J3²^,³	MINT-63863 I2D: score=4
PRPF19	Q9UMS4², ENSP00000227524⁴	MINT-8335209 MINT-8332229 MINT-8328221 MINT-8327994 MINT-8328209 MINT-8328060 MINT-8328016 MINT-8328605 STRING: ENSP00000227524

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000245	spliceosomal complex assembly	IDA	18951082
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IDA	18840686
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006396	RNA processing	TAS	10352938
GO:0006915	apoptotic process	IEA	--

RBM5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RBM5
Search CenterWatch for drugs/clinical trials and news about RBM5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RBM5 gene:

NM_005778.3

Unigene Cluster for RBM5:

RNA binding motif protein 5

Hs.439480 [show with all ESTs]

Unigene Representative Sequence: NM_005778

18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):

ENST00000347869(uc011bdj.2 uc003cyg.3 uc011bdk.2 uc003cyh.3)

ENST00000469838(uc003cyf.3) ENST00000404526 ENST00000441305 ENST00000433556

ENST00000438369 ENST00000464087 ENST00000492472 ENST00000437500 ENST00000417905

ENST00000395174 ENST00000496179 ENST00000462025 ENST00000471995 ENST00000474818

ENST00000494360 ENST00000441812 ENST00000489437

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		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RBM5 (see all 10):
		hsa-miR-323-3p hsa-miR-300 hsa-miR-196a* hsa-miR-381 hsa-miR-708* hsa-miR-3647-3p hsa-miR-151-3p hsa-miR-182

		SwitchGear 3'UTR luciferase reporter plasmid: RBM5 3' UTR sequence

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Additional cDNA sequence:

AB586690.1 AF091263.1 AF103802.4 AF107493.1 AK097195.1 AK297249.1 AK297445.1 AK302766.1

AK314032.1 BC002957.1 EF470865.1 NR_036627.2 U23946.1

24/36 DOTS entries (see all 36):

DT.118496 DT.97810958 DT.100695534 DT.40210335 DT.100695525 DT.100868290 DT.120922408 DT.91755668

DT.91755670 DT.120922421 DT.102833894 DT.87014760 DT.100048976 DT.95263953 DT.101972315 DT.91755672

DT.120922452 DT.40278309 DT.95338616 DT.97854764 DT.120922411 DT.120922431 DT.120922438 DT.431784

24/448 AceView cDNA sequences (see all 448):

BP378471 BM665848 AF091263 NM_005778 AA699426 BM971343 AW572110 AA037589

BQ649702 BX481989 AI218239 AI252236 AI274002 AI417666 CA443558 AW510627

AI378841 BX332188 AI351171 AA767408 AF107492 AA724105 CB988748 CB161287

GeneLoc Exon Structure

5/24 Alternative Splicing Database (ASD) splice patterns (SP) for RBM5 (see all 24) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	·	7d	·	7e	^	8	^	9a	·	9b	·	9c	·	9d	^	10	^	11a	·
SP1:									-		-								-																-		-				-		-								-
SP2:									-		-								-																-		-														-
SP3:																																			-		-				-		-						-		-
SP4:																																																			-
SP5:																																			-		-		-		-		-								-

ExUns:	11b	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	^	24a	·	24b	^	25a	·	25b	·	25c	^	26a	·	26b	^	27	^	28a	·
SP1:													-														-																				-
SP2:																											-																				-
SP3:													-
SP4:													-
SP5:													-

ExUns:	28b	^	29a	·	29b	·	29c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RBM5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RBM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAGCCTAT

About this image
See RBM5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM5

SOURCE GeneReport for Unigene cluster: Hs.439480

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756

Tissue specificity: Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic

cell lines

SABiosciences Custom PCR Arrays for RBM5

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM5 gene from 9/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rbm5^{1 , 5}	RNA binding motif protein 5^{1, 5}	92.11(n)¹ 98.04(a)¹		9 (59.07 cM)⁵ 83486¹ NM_148930.3¹ NP_683732.1¹ 107740495⁵
chicken (Gallus gallus)	Aves	RBM5⁶	Uncharacterized protein	85(a)	1 ↔ 1	12(2956104-2971584)
lizard (Anolis carolinensis)	Reptilia	RBM5⁶	--	88(a)	1 ↔ 1	2(148084340-148103382)
African clawed frog (Xenopus laevis)	Amphibia	MGC68576²	hypothetical protein MGC68576	77.11(n)		BC058770.1
zebrafish (Danio rerio)	Actinopterygii	Dr.24454²	Danio rerio cDNA clone IMAGE6793537, partial cds	78.07(n)		BC057427.1
fruit fly (Drosophila melanogaster)	Insecta	CG4887^{1 , 3}	RNA binding³ CG4887¹	30(a) (best of 2)³ 44.3(n)¹ 36.11(a)¹		21F2³ 33304¹ NM_134738.3¹ NP_608582.2¹
worm (Caenorhabditis elegans)	Secernentea	T08B2.5¹	Protein T08B2.5	41.48(n) 32.75(a)		172312 NM_059393.3 NP_491794.1
thale cress (Arabidopsis thaliana)	eudicotyledons	SUA¹	RNA-binding protein 5/10	45.04(n) 33.15(a)		824590 NM_115283.2 NP_190991.2
rice (Oryza sativa)	Liliopsida	Os02g0167500¹	hypothetical protein	41.3(n) 30.56(a)		4328422 NM_001052542.1 NP_001046007.1

ENSEMBL Gene Tree for RBM5 (if available)
TreeFam Gene Tree for RBM5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RBM5 gene

RBM10² AGGF1² RBM6²

3 SIMAP similar genes for RBM5 using alignment to 7 protein entries: RBM5_HUMAN (see all proteins):

RBM5 variant DKFZp686E2459 RBM10

RBM5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112008798^1,2		--	50124467(+)	`TCACCT/AGAGGT`	2	--	us2k¹		1		CSA	2
rs181552756^1,2		--	50124750(+)	`AAAGCA/GATCAA`	2	--	us2k¹		0	--	--	--	--
rs186610792^1,2		--	50124802(+)	`TTTTGA/CGATAG`	2	--	us2k¹		0	--	--	--	--
rs7650241^1,2	C,	--	50124923(+)	`GATTAC/TAGGTG`	2	--	us2k¹		0	--	--	--	--
rs143336190^1,2		--	50124950(+)	`GCTAAA/TTTTTG`	2	--	us2k¹		0	--	--	--	--
rs10716028^1,2	C,	--	50125101(+)	`TATTT-/ATTTAT`	2	--	us2k¹ tfbs³		0	--	--	--	--
rs9681286^1,2	C,	--	50125219(+)	`ACCTCC/TGCCTC`	2	--	us2k¹		2		NA	4
rs9311447^1,2	C,	--	50125282(+)	`GTGCAC/TGCCAC`	2	--	us2k¹		6		NA CSA	13
rs35263908^1,2	C	--	50125432(+)	`CAGCC-/TTTTTT`	2	--	us2k¹		2		NA	4
rs150033106^1,2		--	50125796(+)	`GTGACA/GAGATC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RBM5 (50126341 - 50156454 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RBM5
2 CNVs: 9993 51107

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RBM5 for disorders           About GeneDecksing

OMIM gene information: 606884    OMIM disorders: --

8 diseases for RBM5:    About MalaCards

renal carcinoma lung cancer carcinoma renal cell carcinoma

rheumatoid arthritis breast cancer arthritis breast carcinoma

1 disease from the University of Copenhagen DISEASES database for RBM5:

Lung cancer

2 Novoseek disease relationships for RBM5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer lung	46.8	4	17606309 (1), 12920317 (1), 16546166 (1)
breast cancer	6.28	2	15338470 (1)

Export disorders for RBM5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RBM5 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with RBM5)

Utopia: connect your pdf to the dynamic
world of online information

RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. (PubMed id 18851835)^{1, 2} Bonnal S.... Valcarcel J. (2008)
Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5. (PubMed id 18840686)^{1, 2} Fushimi K.... Wu J.Y. (2008)
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. (PubMed id 17332742)^{1, 2} Behzadnia N.... Luehrmann R. (2007)
3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. (PubMed id 16585163)^{1, 2} Oh J.J....Slamon D.J. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signals. (PubMed id 15192330)^{1, 2} Rintala-Maki N.D. and Sutherland L.C. (2004)
Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5. (PubMed id 12581154)^{1, 2} Mourtada-Maarabouni M....Williams G.T. (2003)
LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis. (PubMed id 10949932)^{1, 2} Sutherland L.C.... Williams G.T. (2000)
A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. (PubMed id 10352938)^{1, 3} Timmer T.... Buys C.H.C.M. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10181	HGNC: 9902	AceView: RBM5	Ensembl:ENSG00000003756	euGenes: HUgn10181
ECgene: RBM5	H-InvDB: RBM5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RBM5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RBM5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RBM5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RBM5 gene:
Search GeneIP for patents involving RBM5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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RNA binding motif protein 5

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RNA binding motif protein 5

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