Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RBM5 Gene

protein-coding   GIFtS: 62
GCID: GC03P050101

RNA Binding Motif Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RNA Binding Motif Protein 51 2     G152
Putative Tumor Suppressor LUCA152 3     RNA-Binding Protein 52
Renal Carcinoma Antigen NY-REN-92 3     Protein G153
LUCA152 5     RNA-Binding Motif Protein 53
RMB52 5     

External Ids:    HGNC: 99021   Entrez Gene: 101812   Ensembl: ENSG000000037567   OMIM: 6068845   UniProtKB: P527563   

Export aliases for RBM5 gene to outside databases

Previous GC identifers: GC03M049830 GC03M050000 GC03P049980 GC03P050085


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RBM5 Gene:
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of
the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis
through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is
located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation
and progression of several malignancies including lung cancer. (provided by RefSeq, Oct 2011)

GeneCards Summary for RBM5 Gene:
RBM5 (RNA binding motif protein 5) is a protein-coding gene. Diseases associated with RBM5 include lung cancer, and tonsillitis. GO annotations related to this gene include mRNA binding and RNA binding. An important paralog of this gene is RBM10.

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756
Function: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May
modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the
intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several
genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon
6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes
exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis

Gene Wiki entry for RBM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM5 gene promoter:
         Spz1   AML1a   NRSF form 1   HSF1 (long)   Pax-2a   NRSF form 2   CREB   SRY   deltaCREB   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): RBM5 promoter sequence
   Search Chromatin IP Primers for RBM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

RBM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050101:  view genomic region     (about GC identifiers)

Start:
50,126,341 bp from pter      End:
50,156,454 bp from pter
Size:
30,114 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756 (See protein sequence)
Recommended Name: RNA-binding protein 5  
Size: 815 amino acids; 92154 Da
Subunit: Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the
spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which
the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts
with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect
Sequence caution: Sequence=BAG59728.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG59871.1;
Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG63975.1; Type=Erroneous translation; Note=Wrong
choice of CDS;
3 PDB 3D structures from and Proteopedia for RBM5:
2LK0 (3D)        2LK1 (3D)        2LKZ (3D)    
Secondary accessions: B2RA45 B4DM16 B4DMF9 B4DZ63 Q93021 Q9BU14 Q9HDA6 Q9UKY8 Q9UL24
Alternative splicing: 5 isoforms:  P52756-1   P52756-2   P52756-3   P52756-4   P52756-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBM5: NX_P52756

Explore proteomics data for RBM5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005769.1  
    ENSEMBL proteins: 
     ENSP00000343054   ENSP00000419534   ENSP00000384872   ENSP00000390711   ENSP00000414218  
     ENSP00000394622   ENSP00000406119   ENSP00000378603  
    Reactome Protein details: P52756

    RBM5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RBM5
    OriGene Protein Over-expression Lysate for RBM5
    OriGene MassSpec for RBM5
    OriGene Custom Protein Services for RBM5
    GenScript Custom Purified and Recombinant Proteins Services for RBM5
    Novus Biologicals RBM5 Proteins
    Novus Biologicals RBM5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RBM5

    RBM5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RBM5
    OriGene Custom Antibody Services for RBM5
    Novus Biologicals RBM5 Antibodies
    Abcam antibodies for RBM5
    Cloud-Clone Corp. Antibodies for RBM5
    Search ThermoFisher Antibodies for RBM5
    LSBio Antibodies in human, mouse, rat for RBM5

    RBM5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RBM5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RBM5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RBM5
    Cloud-Clone Corp. CLIAs for RBM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GPATCH: G patch domain containing
    RBM: RNA binding motif (RRM) containing

    Selected InterPro protein domains (see all 6):
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015880 Znf_C2H2-like
     IPR000467 G_patch_dom
     IPR001876 Znf_RanBP2
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P52756

    ProtoNet protein and cluster: P52756

    3 Blocks protein domains:
    IPB000467 D111/G-patch domain
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756
    Similarity: Belongs to the RBM5/RBM10 family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    RBM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM5_HUMAN, P52756
    Function: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May
    modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the
    intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several
    genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon
    6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes
    exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis

         Genatlas biochemistry entry for RBM5:
    RNA binding protein 5 in the TSG3B region,homolog with DXS8237E,located in a region duplicated for the
    Xp11.3-p11.23 region containing UBE1 and DXS8237E

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding TAS10352938
    GO:0003723RNA binding TAS10352938
    GO:0003729mRNA binding IDA18840686
         
    RBM5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RBM5:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBM5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RBM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBM5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RBM5

    miRNA
    Products:
        
    miRTarBase miRNAs that target RBM5:
    hsa-mir-30a-5p (MIRT028583), hsa-mir-17-5p (MIRT050882), hsa-mir-17-3p (MIRT050746), hsa-mir-186-5p (MIRT045057), hsa-mir-320b (MIRT036197)

    Block miRNA regulation of human, mouse, rat RBM5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM5 (see all 10):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-196a* hsa-miR-381 hsa-miR-708* hsa-miR-3647-3p hsa-miR-151-3p hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidRBM5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RBM5
    Predesigned siRNA for gene silencing in human, mouse, rat RBM5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RBM5

    Clone
    Products:
         
    OriGene clones in human, mouse for RBM5 (see all 7)
    OriGene ORF clones in mouse, rat for RBM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RBM5 (NM_005778)
    Sino Biological Human cDNA Clone for RBM5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RBM5
    Browse ESI BIO Cell Lines and PureStem Progenitors for RBM5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RBM5_HUMAN, P52756: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS18951082
    GO:0005730NOT nucleolus IDA--

    RBM5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RBM5 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RBM5
        mRNA processing


    1 Reactome Pathway for RBM5
        mRNA Splicing - Major Pathway



    RBM5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM5
    Interactions:

        GeneGlobe Interaction Network for RBM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBM5 (P527561, 2, 3 ENSP000003430544) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX15O431431, 2, ENSP000003367414EBI-714003,EBI-1237044 MINT-8328618 MINT-8328286 MINT-8328168 MINT-8328357 MINT-8328000 MINT-8328264 MINT-8328306 MINT-8328195 MINT-8328330 MINT-8332218 MINT-8328060 MINT-8328016 MINT-8328178 MINT-8334010 STRING: ENSP00000336741
    PRPF19Q9UMS41, 2, ENSP000002275244EBI-714003,EBI-395746 MINT-8335209 MINT-8332229 MINT-8328221 MINT-8327994 MINT-8328209 MINT-8328060 MINT-8328016 MINT-8328605 STRING: ENSP00000227524
    GAPDHP044062, 3, ENSP000002292394MINT-8256404 I2D: score=2 STRING: ENSP00000229239
    SF3A2Q154282, 3, ENSP000002214944MINT-5206016 I2D: score=1 STRING: ENSP00000221494
    U2SURPO150421, 2EBI-714003,EBI-310697 MINT-8334538 MINT-8332526
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly IDA18951082
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA18840686
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing TAS10352938
    GO:0006915apoptotic process IEA--

    RBM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RBM5 gene: 
    NM_005778.3  

    Unigene Cluster for RBM5:

    RNA binding motif protein 5
    Hs.439480  [show with all ESTs]
    Unigene Representative Sequence: NM_005778
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000347869(uc011bdj.2 uc003cyg.3 uc011bdk.2 uc003cyh.3)
    ENST00000469838(uc003cyf.3) ENST00000404526 ENST00000441305 ENST00000433556
    ENST00000438369 ENST00000464087 ENST00000492472 ENST00000437500 ENST00000417905
    ENST00000395174 ENST00000496179 ENST00000462025 ENST00000471995 ENST00000474818
    ENST00000494360 ENST00000441812 ENST00000489437
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RBM5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM5 (see all 10):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-196a* hsa-miR-381 hsa-miR-708* hsa-miR-3647-3p hsa-miR-151-3p hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidRBM5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RBM5
    Predesigned siRNA for gene silencing in human, mouse, rat RBM5
    Clone
    Products:
         
    OriGene clones in human, mouse for RBM5 (see all 7)
    OriGene ORF clones in mouse, rat for RBM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RBM5 (NM_005778)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RBM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM5
      QuantiTect SYBR Green Assays in human, mouse, rat RBM5
      QuantiFast Probe-based Assays in human, mouse, rat RBM5

    Additional mRNA sequence: 

    AB586690.1 AF091263.1 AF103802.4 AF107493.1 AK097195.1 AK297249.1 AK297445.1 AK302766.1 
    AK314032.1 BC002957.1 EF470865.1 NR_036627.2 U23946.1 

    Selected DOTS entries (see all 36):

    DT.118496  DT.97810958  DT.100695534  DT.40210335  DT.100695525  DT.100868290  DT.120922408  DT.91755668 
    DT.91755670  DT.120922421  DT.102833894  DT.87014760  DT.100048976  DT.95263953  DT.101972315  DT.91755672 
    DT.120922452  DT.40278309  DT.95338616  DT.97854764  DT.120922411  DT.120922431  DT.120922438  DT.431784 

    Selected AceView cDNA sequences (see all 448):

    AA907700 CD654182 CA421417 CA427059 AW473505 CB161287 AU133325 AI926273 
    BU617898 AW074329 AA284377 AW001960 AI689425 CD108245 CA443558 AW572110 
    BQ010216 AI378841 AW512057 BQ649702 CA428069 AF091263 CA772168 BM969618 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RBM5 (see all 24)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a ·
    SP1:                          -     -                       -                                               -     -           -     -                       -   
    SP2:                          -     -                       -                                               -     -                                         -   
    SP3:                                                                                                        -     -           -     -                 -     -   
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                        -     -     -     -     -                       -   

    ExUns: 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a ·
    SP1:                                      -                                         -                                                           -               
    SP2:                                                                                -                                                           -               
    SP3:                                      -                                                                                                                     
    SP4:                                      -                                                                                                                     
    SP5:                                      -                                                                                                                     

    ExUns: 28b ^ 29a · 29b · 29c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RBM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RBM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGCCTAT
    RBM5 Expression
    About this image


    RBM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    RBM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439480

    UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756
    Tissue specificity: Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in
    T-leukemic cell lines

        Custom PCR Arrays for RBM5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RBM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM5
    QuantiTect SYBR Green Assays in human, mouse, rat RBM5
    QuantiFast Probe-based Assays in human, mouse, rat RBM5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RBM5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm51 , 5 RNA binding motif protein 51, 5 92.11(n)1
    98.04(a)1
      9 (59.07 cM)5
    834861  NM_148930.31  NP_683732.11 
     1077403715 
    chicken
    (Gallus gallus)
    Aves RBM56
    RNA binding motif protein 5
    85(a)
    1 ↔ 1
    12(3145246-3161321)
    lizard
    (Anolis carolinensis)
    Reptilia RBM56
    RNA binding motif protein 5
    85(a)
    1 ↔ 1
    2(148084298-148107079)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685762 hypothetical protein MGC68576 77.11(n)    BC058770.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.244542 Danio rerio cDNA clone IMAGE6793537, partial cds 78.07(n)    BC057427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48873 RNA binding 30(a)
    (best of 2)
      21F2   --
    worm
    (Caenorhabditis elegans)
    Secernentea T08B2.51 T08B2.5 41.96(n)
    32.51(a)
      172312  NM_182021.1  NP_871821.1 


    ENSEMBL Gene Tree for RBM5 (if available)
    TreeFam Gene Tree for RBM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RBM5 gene
    RBM102  RBM62  
    3 SIMAP similar genes for RBM5 using alignment to 7 protein entries:     RBM5_HUMAN (see all proteins):
    RBM5 variant    DKFZp686E2459    RBM10

    RBM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RBM5 (see all 510)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1120087981,2
    C,F--50124467(+) TCACCT/AGAGGT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1815527561,2
    --50124750(+) AAAGCA/GATCAA 2 -- us2k10--------
    rs1866107921,2
    C--50124802(+) TTTTGA/CGATAG 2 -- us2k10--------
    rs76502411,2
    C--50124923(+) gattaC/Taggtg 2 -- us2k10--------
    rs1433361901,2
    C--50124950(+) GCTAAA/TTTTTG 2 -- us2k10--------
    rs107160281,2
    C--50125101(+) tattt-/Atttat 2 -- us2k1 tfbs30--------
    rs96812861,2
    C--50125219(+) acctcC/Tgcctc 2 -- us2k12Minor allele frequency- T:0.25NA 4
    rs93114471,2
    C--50125282(+) gtgcaC/Tgccac 2 -- us2k16Minor allele frequency- T:0.00NA CSA 13
    rs352639081,2
    C--50125432(+) CAGCC-/TTTTTT 2 -- us2k12Minor allele frequency- T:0.25NA 4
    rs1500331061,2
    --50125796(+) GTGACA/GAGATC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RBM5 (50126341 - 50156454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RBM5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv818139CNV Loss17921354
    nsv523662CNV Loss19592680
    nsv822083CNV Loss20364138
    nsv876769CNV Loss21882294
    nsv876767CNV Loss21882294
    nsv515986CNV Loss19592680
    nsv834690CNV Loss17160897
    nsv876768CNV Gain21882294
    dgv806n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM5
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606884    OMIM disorders: --

    14 diseases for RBM5:    
    About MalaCards
    lung cancer    tonsillitis    renal cell carcinoma    lung adenocarcinoma
    rheumatoid arthritis    arthritis    breast cancer    malaria
    adenocarcinoma    thyroiditis    cerebritis    prostate cancer
    prostatitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for RBM5:
    Lung cancer

    RBM5 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RBM5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 46.8 4 17606309 (1), 12920317 (1), 16546166 (1)
    breast cancer 6.28 2 15338470 (1)

    Genetic Association Database (GAD): RBM5

    Export disorders for RBM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RBM5 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with RBM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. (PubMed id 23935508)1, 3 O'Bryan M.K....Jamsai D. (PLoS Genet. 2013)
    2. RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. (PubMed id 18851835)1, 2 Bonnal S.... Valcarcel J. (Mol. Cell 2008)
    3. Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5. (PubMed id 18840686)1, 2 Fushimi K.... Wu J.Y. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Composition and three-dimensional EM structure of double affinity- purified, human prespliceosomal A complexes. (PubMed id 17332742)1, 2 Behzadnia N.... Luehrmann R. (EMBO J. 2007)
    5. 3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. (PubMed id 16585163)1, 2 Oh J.J....Slamon D.J. (Cancer Res. 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signals. (PubMed id 15192330)1, 2 Rintala-Maki N.D. and Sutherland L.C. (Apoptosis 2004)
    9. Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5. (PubMed id 12581154)1, 2 Mourtada-Maarabouni M.... Williams G.T. (Genes Cells 2003)
    10. LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis. (PubMed id 10949932)1, 2 Sutherland L.C.... Williams G.T. (Oncogene 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10181 HGNC: 9902 AceView: RBM5 Ensembl:ENSG00000003756 euGenes: HUgn10181
    ECgene: RBM5 H-InvDB: RBM5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RBM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RBM5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RBM5 gene:
    Search GeneIP for patents involving RBM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RBM5   OriGene RNAi products in human, mouse, rat for RBM5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RBM5  
     OriGene MassSpec something-or-other for RBM5   OriGene clones in human, mouse for RBM5  
     OriGene qSTAR qPCR primer pairs in human, mouse for RBM5   OriGene Purified Protein for RBM5  
     OriGene ORF clones in mouse, rat for RBM5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RBM5   OriGene Custom Protein Services for RBM5  

     
     
     Block miRNA regulation of human, mouse, rat RBM5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RBM5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM5 Predesigned siRNA for gene silencing in human, mouse, rat RBM5
     QuantiFast Probe-based Assays in human, mouse, rat RBM5 QuantiTect SYBR Green Assays in human, mouse, rat RBM5
     Custom PCR Arrays for RBM5 Search Chromatin IP Primers for RBM5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM5  GeneGlobe Interaction Network for RBM5
     Regulatory tfbs in RBM5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RBM5 GenScript cDNA clones with any tag delivered in your preferred vector for RBM5
     GenScript Custom Assay Services for RBM5 GenScript Custom overexpressing Cell Line Services for RBM5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RBM5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RBM5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RBM5 antibodies
     RBM5 proteins
     RBM5 lysates
     Antibodies for RBM5
     See all of Abcam's Antibodies, Kits and Proteins for RBM5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RBM5
     Antibodies for RBM5
     ELISAs for RBM5
     CLIAs for RBM5



     Browse ESI BIO Cell Lines and PureStem Progenitors for RBM5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM5
     SwitchGear 3'UTR luciferase reporter plasmids for RBM5
     SwitchGear Promoter luciferase reporter plasmids for RBM5
     Search ThermoFisher Antibodies for RBM5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBM5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RBM5
     LSBio Antibodies in human, mouse, rat for RBM5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RBM5 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4