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Aliases for RBM5 Gene

Aliases for RBM5 Gene

  • RNA Binding Motif Protein 5 2 3
  • Putative Tumor Suppressor LUCA15 3 4
  • Renal Carcinoma Antigen NY-REN-9 3 4
  • LUCA15 3 6
  • RMB5 3 6
  • RNA-Binding Motif Protein 5 4
  • RNA-Binding Protein 5 3
  • Protein G15 4
  • G15 3
  • H37 3

External Ids for RBM5 Gene

Previous GeneCards Identifiers for RBM5 Gene

  • GC03M049830
  • GC03M050000
  • GC03P049980
  • GC03P050085

Summaries for RBM5 Gene

Entrez Gene Summary for RBM5 Gene

  • This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

GeneCards Summary for RBM5 Gene

RBM5 (RNA Binding Motif Protein 5) is a Protein Coding gene. Diseases associated with RBM5 include lung cancer. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and mRNA binding. An important paralog of this gene is RBM10.

UniProtKB/Swiss-Prot for RBM5 Gene

  • Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5 and 3 splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

Gene Wiki entry for RBM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM5 Gene

Genomics for RBM5 Gene

Regulatory Elements for RBM5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBM5 Gene

Start:
50,088,908 bp from pter
End:
50,119,021 bp from pter
Size:
30,114 bases
Orientation:
Plus strand

Genomic View for RBM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM5 Gene

Proteins for RBM5 Gene

  • Protein details for RBM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52756-RBM5_HUMAN
    Recommended name:
    RNA-binding protein 5
    Protein Accession:
    P52756
    Secondary Accessions:
    • B2RA45
    • B4DM16
    • B4DMF9
    • B4DZ63
    • Q93021
    • Q9BU14
    • Q9HDA6
    • Q9UKY8
    • Q9UL24

    Protein attributes for RBM5 Gene

    Size:
    815 amino acids
    Molecular mass:
    92154 Da
    Quaternary structure:
    • Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect.
    SequenceCaution:
    • Sequence=BAG59728.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG59871.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG63975.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM5 Gene

    Alternative splice isoforms for RBM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM5 Gene

Proteomics data for RBM5 Gene at MOPED

Post-translational modifications for RBM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM5 Gene

No data available for DME Specific Peptides for RBM5 Gene

Domains for RBM5 Gene

Gene Families for RBM5 Gene

HGNC:
  • GPATCH :G patch domain containing
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for RBM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52756

UniProtKB/Swiss-Prot:

RBM5_HUMAN :
  • P52756
Domain:
  • Contains 1 G-patch domain.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RBM5/RBM10 family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with RBM5: view

Function for RBM5 Gene

Molecular function for RBM5 Gene

GENATLAS Biochemistry: RNA binding protein 5 in the TSG3B region,homolog with DXS8237E,located in a region duplicated for the Xp11.3-p11.23 region containing UBE1 and DXS8237E
UniProtKB/Swiss-Prot Function: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5 and 3 splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

Gene Ontology (GO) - Molecular Function for RBM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding TAS 10352938
GO:0003723 RNA binding TAS 10352938
GO:0003729 mRNA binding IDA 18840686
genes like me logo Genes that share ontologies with RBM5: view

Phenotypes for RBM5 Gene

GenomeRNAi human phenotypes for RBM5:
genes like me logo Genes that share phenotypes with RBM5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM5 Gene

Localization for RBM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM5 Gene COMPARTMENTS Subcellular localization image for RBM5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RBM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18951082
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex TAS 18951082
genes like me logo Genes that share ontologies with RBM5: view

Pathways for RBM5 Gene

genes like me logo Genes that share pathways with RBM5: view

Pathways by source for RBM5 Gene

Gene Ontology (GO) - Biological Process for RBM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IDA 18951082
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 18840686
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing TAS 10352938
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with RBM5: view

Transcripts for RBM5 Gene

Unigene Clusters for RBM5 Gene

RNA binding motif protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RBM5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - - - - - - - -
SP13: - - -
SP14: - - - - - -
SP15: - -
SP16: - -
SP17: - - - - - - - - - - - - - - - - - - - -
SP18: -
SP19:
SP20: - -
SP21:
SP22:
SP23:
SP24:

ExUns: 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a ·
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: - -
SP7:
SP8:
SP9: - - - -
SP10:
SP11: - - - -
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22: -
SP23: -
SP24:

ExUns: 28b ^ 29a · 29b · 29c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for RBM5 Gene

GeneLoc Exon Structure for
RBM5
ECgene alternative splicing isoforms for
RBM5

Expression for RBM5 Gene

mRNA expression in normal human tissues for RBM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM5 Gene

SOURCE GeneReport for Unigene cluster for RBM5 Gene Hs.439480

mRNA Expression by UniProt/SwissProt for RBM5 Gene

P52756-RBM5_HUMAN
Tissue specificity: Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines
genes like me logo Genes that share expressions with RBM5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RBM5 Gene

Orthologs for RBM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM5 35
  • 99.67 (n)
  • 99.88 (a)
RBM5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM5 35
  • 93.29 (n)
  • 99.14 (a)
RBM5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM5 35
  • 94.11 (n)
  • 99.51 (a)
RBM5 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm5 35
  • 92.11 (n)
  • 98.04 (a)
Rbm5 16
Rbm5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM5 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM5 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm5 35
  • 92.27 (n)
  • 98.28 (a)
chicken
(Gallus gallus)
Aves RBM5 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM5 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68576 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm5 35
  • 72.77 (n)
  • 80.2 (a)
Str.11018 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12407 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24454 35
rbm5 35
  • 67.25 (n)
  • 69.2 (a)
rbm5 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4887 36
  • 26 (a)
ManyToMany
CG4896 36
  • 26 (a)
ManyToMany
CG4896 37
  • 28 (a)
CG4887 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea T08B2.5 35
  • 41.96 (n)
  • 32.51 (a)
T08B2.5 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for RBM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM5 Gene

ENSEMBL:
Gene Tree for RBM5 (if available)
TreeFam:
Gene Tree for RBM5 (if available)

Paralogs for RBM5 Gene

Paralogs for RBM5 Gene

Selected SIMAP similar genes for RBM5 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RBM5: view

Variants for RBM5 Gene

Sequence variations from dbSNP and Humsavar for RBM5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14834 -- 50,118,775(-) TAGGA(A/G)TGTGA utr-variant-3-prime, nc-transcript-variant
rs1061474 -- 50,107,518(+) AGCGC(C/T)TTCTC synonymous-codon, reference, nc-transcript-variant
rs1138536 -- 50,115,923(+) ATCTA(C/T)CGACG synonymous-codon, reference, nc-transcript-variant
rs2013208 -- 50,091,966(-) CACAC(A/G)GCCCA intron-variant, upstream-variant-2KB
rs2071209 -- 50,114,765(-) GGCTC(A/C)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM5 Gene

Variant ID Type Subtype PubMed ID
nsv876767 CNV Loss 21882294
nsv834690 CNV Loss 17160897
nsv515986 CNV Loss 19592680
dgv806n67 CNV Gain 20364138
nsv822083 CNV Loss 20364138
nsv818139 CNV Loss 17921354
nsv876768 CNV Gain 21882294
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294

Relevant External Links for RBM5 Gene

HapMap Linkage Disequilibrium report
RBM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM5 Gene

Disorders for RBM5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RBM5 Gene including...

Search for RBM5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RBM5 Gene

(2) Novoseek inferred disease relationships for RBM5 Gene

Disease -log(P) Hits PubMed IDs
cancer lung 46.8 3
breast cancer 6.28 1

Relevant External Links for RBM5

Genetic Association Database (GAD)
RBM5
genes like me logo Genes that share disorders with RBM5: view

No data available for UniProtKB/Swiss-Prot for RBM5 Gene

Publications for RBM5 Gene

  1. Genetic instability of RBM5/LUCA-15/H37 in MCF-7 breast carcinoma sublines may affect susceptibility to apoptosis. (PMID: 15338470) Rintala-Maki N.D. … Sutherland L.C. (Cell Biochem. Funct. 2004) 3 23
  2. Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes. (PMID: 16546166) Mourtada-Maarabouni M. … Williams G.T. (Exp. Cell Res. 2006) 3 23
  3. The apoptosis modulator and tumour suppressor protein RBM5 is a phosphoprotein. (PMID: 16927403) Shu Y. … Sutherland L.C. (Cell Biochem. Funct. 2007) 3 23
  4. The two single nucleotide polymorphisms in the H37/RBM5 tumour suppressor gene at 3p21.3 correlated with different subtypes of non-small cell lung cancers. (PMID: 17606309) Oh J.J. … Slamon D.J. (Lung Cancer 2007) 3 23
  5. RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours. (PMID: 17908320) Wang K. … Sutherland L.C. (BMC Genomics 2007) 3 23

Products for RBM5 Gene

Sources for RBM5 Gene

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