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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBM5 Gene

protein-coding   GIFtS: 63
GCID: GC03P050101

RNA Binding Motif Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RNA Binding Motif Protein 51 2     G152
Putative Tumor Suppressor LUCA152 3     RNA-Binding Protein 52
Renal Carcinoma Antigen NY-REN-92 3     Protein G153
LUCA152 5     RNA-Binding Motif Protein 53
RMB52 5     

External Ids:    HGNC: 99021   Entrez Gene: 101812   Ensembl: ENSG000000037567   OMIM: 6068845   UniProtKB: P527563   
ORGUL members:         
NONCODE14:n410156      

Export aliases for RBM5 gene to outside databases

Previous GC identifers: GC03M049830 GC03M050000 GC03P049980 GC03P050085


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBM5 Gene:
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of
the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis
through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is
located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation
and progression of several malignancies including lung cancer. (provided by RefSeq, Oct 2011)

GeneCards Summary for RBM5 Gene: 
RBM5 (RNA binding motif protein 5) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RBM5 include lung cancer, and renal cell carcinoma, and among its related super-pathways are mRNA Processing and Generic Transcription Pathway. GO annotations related to this gene include mRNA binding and RNA binding. An important paralog of this gene is RBM10.

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756
Function: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May
modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the
intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several
genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon
6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes
exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis

Gene Wiki entry for RBM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBM5 gene promoter:
         Spz1   AML1a   NRSF form 1   HSF1 (long)   Pax-2a   NRSF form 2   CREB   SRY   deltaCREB   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): RBM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

RBM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050101:  view genomic region     (about GC identifiers)

Start:
50,126,341 bp from pter      End:
50,156,454 bp from pter
Size:
30,114 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756 (See protein sequence)
Recommended Name: RNA-binding protein 5  
Size: 815 amino acids; 92154 Da
Subunit: Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the
spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which
the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts
with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect
Subcellular location: Nucleus
Sequence caution: Sequence=BAG59728.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG59871.1;
Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG63975.1; Type=Erroneous translation; Note=Wrong
choice of CDS;
3 PDB 3D structures from and Proteopedia for RBM5:
2LK0 (3D)        2LK1 (3D)        2LKZ (3D)    
Secondary accessions: B2RA45 B4DM16 B4DMF9 B4DZ63 Q93021 Q9BU14 Q9HDA6 Q9UKY8 Q9UL24
Alternative splicing: 5 isoforms:  P52756-1   P52756-2   P52756-3   P52756-4   P52756-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBM5: NX_P52756

Explore proteomics data for RBM5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52756

  • RBM5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RBM5 Protein Expression
    REFSEQ proteins: NP_005769.1  
    ENSEMBL proteins: 
     ENSP00000343054   ENSP00000419534   ENSP00000384872   ENSP00000390711   ENSP00000414218  
     ENSP00000394622   ENSP00000406119   ENSP00000378603  
    Reactome Protein details: P52756
    Human Recombinant Protein Products for RBM5: 
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    Novus Biologicals RBM5 Proteins
    Novus Biologicals RBM5 Lysates
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    Cloud-Clone Corp. Proteins for RBM5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS18951082
    GO:0005730NOT nucleolus IDA--

    RBM5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPATCH: G patch domain containing
    RBM: RNA binding motif (RRM) containing

    5/6 InterPro protein domains (see all 6):
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015880 Znf_C2H2-like
     IPR000467 G_patch_dom
     IPR001876 Znf_RanBP2
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P52756

    ProtoNet protein and cluster: P52756

    3 Blocks protein domains:
    IPB000467 D111/G-patch domain
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756
    Similarity: Belongs to the RBM5/RBM10 family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    RBM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM5_HUMAN, P52756
    Function: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May
    modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the
    intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several
    genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon
    6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes
    exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis

         Genatlas biochemistry entry for RBM5:
    RNA binding protein 5 in the TSG3B region,homolog with DXS8237E,located in a region duplicated for the
    Xp11.3-p11.23 region containing UBE1 and DXS8237E

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding TAS10352938
    GO:0003723RNA binding TAS10352938
    GO:0003729mRNA binding IDA18840686
         
    RBM5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RBM5:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RBM5 
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    SwitchGear 3'UTR luciferase reporter plasmidRBM5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RBM5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RBM5
        mRNA processing

    5        Reactome Pathways for RBM5
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    RBM5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/119 Interacting proteins for RBM5 (P527562, 3 ENSP000003430544) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX15O431432, ENSP000003367414MINT-8328618 MINT-8328286 MINT-8328168 MINT-8328357 MINT-8328000 MINT-8328264 MINT-8328306 MINT-8328195 MINT-8328330 MINT-8332218 MINT-8328060 MINT-8328016 MINT-8328178 MINT-8334010 STRING: ENSP00000336741
    GAPDHP044062, 3, ENSP000002292394MINT-8256404 I2D: score=2 STRING: ENSP00000229239
    SF3A2Q154282, 3, ENSP000002214944MINT-5206016 I2D: score=1 STRING: ENSP00000221494
    LRIF1Q5T3J32, 3MINT-63863 I2D: score=4 
    PRPF19Q9UMS42, ENSP000002275244MINT-8335209 MINT-8332229 MINT-8328221 MINT-8327994 MINT-8328209 MINT-8328060 MINT-8328016 MINT-8328605 STRING: ENSP00000227524
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly IDA18951082
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA18840686
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing TAS10352938
    GO:0006915apoptotic process IEA--

    RBM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBM5

    Search CenterWatch for drugs/clinical trials and news about RBM5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RBM5 gene: 
    NM_005778.3  

    Unigene Cluster for RBM5:

    RNA binding motif protein 5
    Hs.439480  [show with all ESTs]
    Unigene Representative Sequence: NM_005778
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000347869(uc011bdj.2 uc003cyg.3 uc011bdk.2 uc003cyh.3)
    ENST00000469838(uc003cyf.3) ENST00000404526 ENST00000441305 ENST00000433556
    ENST00000438369 ENST00000464087 ENST00000492472 ENST00000437500 ENST00000417905
    ENST00000395174 ENST00000496179 ENST00000462025 ENST00000471995 ENST00000474818
    ENST00000494360 ENST00000441812 ENST00000489437
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RBM5 (see all 10):
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    Additional mRNA sequence: 

    AB586690.1 AF091263.1 AF103802.4 AF107493.1 AK097195.1 AK297249.1 AK297445.1 AK302766.1 
    AK314032.1 BC002957.1 EF470865.1 NR_036627.2 U23946.1 

    24/36 DOTS entries (see all 36):

    DT.118496  DT.97810958  DT.100695534  DT.40210335  DT.100695525  DT.100868290  DT.120922408  DT.91755668 
    DT.91755670  DT.120922421  DT.102833894  DT.87014760  DT.100048976  DT.95263953  DT.101972315  DT.91755672 
    DT.120922452  DT.40278309  DT.95338616  DT.97854764  DT.120922411  DT.120922431  DT.120922438  DT.431784 

    24/448 AceView cDNA sequences (see all 448):

    AA724105 BC002957 BM667503 AA284377 AI333452 CB988748 BM913605 BM969618 
    AW510627 AI417666 BU617898 AI378841 AA767408 BQ649702 BM971343 BM478143 
    AW452587 BP364538 BP378471 AA648939 AI350197 CD654182 CA428069 CA944541 

    GeneLoc Exon Structure

    5/24 Alternative Splicing Database (ASD) splice patterns (SP) for RBM5 (see all 24)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a ·
    SP1:                          -     -                       -                                               -     -           -     -                       -   
    SP2:                          -     -                       -                                               -     -                                         -   
    SP3:                                                                                                        -     -           -     -                 -     -   
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                        -     -     -     -     -                       -   

    ExUns: 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a ·
    SP1:                                      -                                         -                                                           -               
    SP2:                                                                                -                                                           -               
    SP3:                                      -                                                                                                                     
    SP4:                                      -                                                                                                                     
    SP5:                                      -                                                                                                                     

    ExUns: 28b ^ 29a · 29b · 29c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RBM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBM5 expression in normal human tissues (normalized intensities)      RBM5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGCCTAT
    RBM5 Expression
    About this image


    RBM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See RBM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBM5

    SOURCE GeneReport for Unigene cluster: Hs.439480

    UniProtKB/Swiss-Prot: RBM5_HUMAN, P52756
    Tissue specificity: Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in
    T-leukemic cell lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBM5 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm51 , 5 RNA binding motif protein 51, 5 92.11(n)1
    98.04(a)1
      9 (59.07 cM)5
    834861  NM_148930.31  NP_683732.11 
     1077403715 
    chicken
    (Gallus gallus)
    Aves RBM56
    RNA binding motif protein 5
    86(a)
    1 ↔ 1
    12(3145246-3161321)
    lizard
    (Anolis carolinensis)
    Reptilia RBM56
    RNA binding motif protein 5
    86(a)
    1 ↔ 1
    2(148084298-148107079)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685762 hypothetical protein MGC68576 77.11(n)    BC058770.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.244542 Danio rerio cDNA clone IMAGE6793537, partial cds 78.07(n)    BC057427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48871 , 3 RNA binding3
    CG48871
    30(a)
    (best of 2)3
    44.3(n)1
    36.11(a)1
      21F23
    333041  NM_134738.31  NP_608582.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T08B2.51 Protein T08B2.5 41.48(n)
    32.75(a)
      172312  NM_059393.3  NP_491794.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SUA1 RNA-binding protein 5/10 45.04(n)
    33.15(a)
      824590  NM_115283.2  NP_190991.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g01675001 hypothetical protein 41.3(n)
    30.56(a)
      4328422  NM_001052542.1  NP_001046007.1 


    ENSEMBL Gene Tree for RBM5 (if available)
    TreeFam Gene Tree for RBM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RBM5 gene
    RBM102  RBM62  
    3 SIMAP similar genes for RBM5 using alignment to 7 protein entries:     RBM5_HUMAN (see all proteins):
    RBM5 variant    DKFZp686E2459    RBM10

    RBM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/510 SNPs in RBM5 are shown (see all 510)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1120087981,2
    C,F--50124467(+) TCACCT/AGAGGT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1815527561,2
    --50124750(+) AAAGCA/GATCAA 2 -- us2k10--------
    rs1866107921,2
    C--50124802(+) TTTTGA/CGATAG 2 -- us2k10--------
    rs76502411,2
    C--50124923(+) gattaC/Taggtg 2 -- us2k10--------
    rs1433361901,2
    C--50124950(+) GCTAAA/TTTTTG 2 -- us2k10--------
    rs107160281,2
    C--50125101(+) tattt-/Atttat 2 -- us2k1 tfbs30--------
    rs96812861,2
    C--50125219(+) acctcC/Tgcctc 2 -- us2k12Minor allele frequency- T:0.25NA 4
    rs93114471,2
    C--50125282(+) gtgcaC/Tgccac 2 -- us2k16Minor allele frequency- T:0.00NA CSA 13
    rs352639081,2
    C--50125432(+) CAGCC-/TTTTTT 2 -- us2k12Minor allele frequency- T:0.25NA 4
    rs1500331061,2
    --50125796(+) GTGACA/GAGATC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RBM5 (50126341 - 50156454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RBM5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv818139CNV Loss17921354
    nsv523662CNV Loss19592680
    nsv822083CNV Loss20364138
    nsv876769CNV Loss21882294
    nsv876767CNV Loss21882294
    nsv515986CNV Loss19592680
    nsv834690CNV Loss17160897
    nsv876768CNV Gain21882294
    dgv806n67CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606884    OMIM disorders: --

    5 diseases for RBM5:    About MalaCards
    lung cancer    renal cell carcinoma    rheumatoid arthritis    arthritis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RBM5:
    Lung cancer

    RBM5 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RBM5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 46.8 4 17606309 (1), 12920317 (1), 16546166 (1)
    breast cancer 6.28 2 15338470 (1)

    Genetic Association Database (GAD): RBM5

    Export disorders for RBM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBM5 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with RBM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RBM5 Is a Male Germ Cell Splicing Factor and Is Requir ed for Spermatid Differentiation and Male Fertility. (PubMed id 23935508)1, 3 O'Bryan M.K....Jamsai D. (2013)
    2. RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. (PubMed id 18851835)1, 2 Bonnal S.... Valcarcel J. (2008)
    3. Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5. (PubMed id 18840686)1, 2 Fushimi K.... Wu J.Y. (2008)
    4. Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. (PubMed id 17332742)1, 2 Behzadnia N.... Luehrmann R. (2007)
    5. 3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. (PubMed id 16585163)1, 2 Oh J.J....Slamon D.J. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signals. (PubMed id 15192330)1, 2 Rintala-Maki N.D. and Sutherland L.C. (2004)
    9. Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5. (PubMed id 12581154)1, 2 Mourtada-Maarabouni M....Williams G.T. (2003)
    10. LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis. (PubMed id 10949932)1, 2 Sutherland L.C.... Williams G.T. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10181 HGNC: 9902 AceView: RBM5 Ensembl:ENSG00000003756 euGenes: HUgn10181
    ECgene: RBM5 H-InvDB: RBM5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RBM5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RBM5 gene:
    Search GeneIP for patents involving RBM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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