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Aliases for RBM4B Gene

Aliases for RBM4B Gene

  • RNA Binding Motif Protein 4B 2 3
  • RNA-Binding Motif Protein 30 3 4
  • RBM30 3 4
  • Zinc Finger CCHC-Type And RNA Binding Motif 3B 3
  • RNA Binding Motif Protein 30 2
  • RNA-Binding Motif Protein 4B 4
  • RNA-Binding Protein 4B 3
  • RNA-Binding Protein 30 4
  • ZCCHC21B 3
  • ZCCHC15 3
  • ZCRB3B 3
  • RBM4L 3

External Ids for RBM4B Gene

Previous HGNC Symbols for RBM4B Gene

  • RBM30

Previous GeneCards Identifiers for RBM4B Gene

  • GC11M066190
  • GC11M066432
  • GC11M062761

Summaries for RBM4B Gene

GeneCards Summary for RBM4B Gene

RBM4B (RNA Binding Motif Protein 4B) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM14.

UniProtKB/Swiss-Prot for RBM4B Gene

  • Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3-UTR of the PER1 mRNA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM4B Gene

Genomics for RBM4B Gene

Regulatory Elements for RBM4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBM4B Gene

Start:
66,664,994 bp from pter
End:
66,677,921 bp from pter
Size:
12,928 bases
Orientation:
Minus strand

Genomic View for RBM4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM4B Gene

Proteins for RBM4B Gene

  • Protein details for RBM4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ04-RBM4B_HUMAN
    Recommended name:
    RNA-binding protein 4B
    Protein Accession:
    Q9BQ04
    Secondary Accessions:
    • B3KT83

    Protein attributes for RBM4B Gene

    Size:
    359 amino acids
    Molecular mass:
    40150 Da
    Quaternary structure:
    • Interacts with TNPO3, which may mediate nuclear import of the protein.

    Three dimensional structures from OCA and Proteopedia for RBM4B Gene

neXtProt entry for RBM4B Gene

Proteomics data for RBM4B Gene at MOPED

Post-translational modifications for RBM4B Gene

  • Ubiquitination at Lys3, Lys27, Lys35, Lys59, and Lys139
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM4B Gene

Antibody Products

No data available for DME Specific Peptides for RBM4B Gene

Domains for RBM4B Gene

Gene Families for RBM4B Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • ZCCHC :Zinc fingers, CCHC domain containing

Suggested Antigen Peptide Sequences for RBM4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ04

UniProtKB/Swiss-Prot:

RBM4B_HUMAN :
  • Q9BQ04
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with RBM4B: view

Function for RBM4B Gene

Molecular function for RBM4B Gene

UniProtKB/Swiss-Prot Function:
Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3-UTR of the PER1 mRNA (By similarity).

Gene Ontology (GO) - Molecular Function for RBM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 23455924
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM4B: view

Phenotypes for RBM4B Gene

genes like me logo Genes that share phenotypes with RBM4B: view

Animal Model Products

miRNA for RBM4B Gene

miRTarBase miRNAs that target RBM4B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM4B Gene

Localization for RBM4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM4B Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM4B Gene COMPARTMENTS Subcellular localization image for RBM4B gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with RBM4B: view

Pathways for RBM4B Gene

SuperPathways for RBM4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006417 regulation of translation ISS --
GO:0007623 circadian rhythm ISS --
GO:0008380 RNA splicing IEA --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with RBM4B: view

No data available for Pathways by source for RBM4B Gene

Transcripts for RBM4B Gene

Unigene Clusters for RBM4B Gene

RNA binding motif protein 4B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM4B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM4B Gene

No ASD Table

Relevant External Links for RBM4B Gene

GeneLoc Exon Structure for
RBM4B
ECgene alternative splicing isoforms for
RBM4B

Expression for RBM4B Gene

mRNA expression in normal human tissues for RBM4B Gene

Protein differential expression in normal tissues for RBM4B Gene

This gene is overexpressed in Bone (16.8), Peripheral blood mononuclear cells (15.7), Lung (9.5), and Cervix (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM4B Gene

SOURCE GeneReport for Unigene cluster for RBM4B Gene Hs.618713

mRNA Expression by UniProt/SwissProt for RBM4B Gene

Q9BQ04-RBM4B_HUMAN
Tissue specificity: Expressed in liver and kidney (at protein level). Ubiquitously expressed.
genes like me logo Genes that share expressions with RBM4B: view

Expression partners for RBM4B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBM4B Gene

Orthologs for RBM4B Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBM4B 35
  • 92.48 (n)
  • 98.05 (a)
RBM4B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM4B 35
  • 93.59 (n)
  • 98.61 (a)
RBM4B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm4b 35
  • 89.54 (n)
  • 94.96 (a)
Rbm4b 16
Rbm4b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBM4B 35
  • 99.16 (n)
  • 100 (a)
RBM4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm4b 35
  • 89.54 (n)
  • 95.52 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RBM4B 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859276 35
  • 62.02 (n)
  • 63.57 (a)
-- 36
  • 92 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75893 35
rbm4b 35
  • 58.41 (n)
  • 55.96 (a)
zebrafish
(Danio rerio)
Actinopterygii rbm4.1 35
  • 61.6 (n)
  • 60.13 (a)
wufc25a01 35
rbm4.1 36
  • 47 (a)
ManyToMany
rbm4.2 36
  • 46 (a)
ManyToMany
rbm4.3 36
  • 43 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10235 35
fruit fly
(Drosophila melanogaster)
Insecta lark 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnp-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for RBM4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM4B Gene

ENSEMBL:
Gene Tree for RBM4B (if available)
TreeFam:
Gene Tree for RBM4B (if available)

Paralogs for RBM4B Gene

Paralogs for RBM4B Gene

Selected SIMAP similar genes for RBM4B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for RBM4B Gene

genes like me logo Genes that share paralogs with RBM4B: view

Variants for RBM4B Gene

Sequence variations from dbSNP and Humsavar for RBM4B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs478807 -- 66,674,291(-) agccg(A/C)gatca intron-variant
rs483797 -- 66,672,939(-) GCTTT(G/T)GGCCT intron-variant
rs511833 -- 66,670,824(-) TTTCC(A/C)ttttt intron-variant
rs522932 -- 66,672,699(-) gccaa(C/G)atggt intron-variant
rs534575 -- 66,670,676(-) CAATT(G/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM4B Gene

Variant ID Type Subtype PubMed ID
nsv522277 CNV Loss 19592680
nsv897789 CNV Gain 21882294
nsv518919 CNV Loss 19592680
nsv897790 CNV Loss 21882294
nsv897791 CNV Loss 21882294

Relevant External Links for RBM4B Gene

HapMap Linkage Disequilibrium report
RBM4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM4B Gene

Disorders for RBM4B Gene

No disorders were found for RBM4B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RBM4B Gene

Publications for RBM4B Gene

  1. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A novel splicing regulator shares a nuclear import pathway with SR proteins. (PMID: 12628928) Lai M.-C. … Tarn W.-Y. (EMBO J. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RBM4B Gene

Sources for RBM4B Gene

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