RBM4B Gene
protein-coding GIFtS: 45
GCID: GC11M066432
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RNA binding motif protein 4B(Previous name: RNA binding motif protein 30 )
(Previous symbol: RBM30)
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Aliases
for RBM4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein 4B1 2 | | RNA-Binding Motif Protein 302 3 | | RBM301 2 3 | | RNA-Binding Motif Protein 4B2 3 | | RBM4L1 2 | | RNA-Binding Protein 302 3 | | ZCCHC151 2 | | MGC108711 | | ZCCHC21B1 2 | | RNA-Binding Protein 4B2 | | ZCRB3B1 2 | | Zinc Finger CCHC-Type And RNA Binding Motif 3B2 | | RNA Binding Motif Protein 301 2 | | |
Export aliases for RBM4B gene to outside databasesPrevious GC identifers: GC11M066190 GC11M062761 |
Summaries
for RBM4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RBM4B_HUMAN, Q9BQ04Function: Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the3'-UTR of the PER1 mRNA (By similarity)
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Genomic Views
for RBM4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBM4B gene promoter:
c-Fos NF-1 AP-1 c-Ets-1 CREB HOXA5 deltaCREB c-Myb c-Jun ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBM4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13RBM4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M066432: view genomic region
(about GC identifiers)
Start:
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66,432,469 bp from pter |
End:
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66,445,392 bp from pter |
Size:
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12,924 bases |
Orientation:
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minus strand |
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Proteins
for RBM4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBM4B_HUMAN, Q9BQ04 (See
protein sequence)Recommended Name: RNA-binding protein 4B Size: 359 amino acids; 40150 Da
Subunit: Interacts with TNPO3, which may mediate nuclear import of the protein
Subcellular location: Nucleus. Nucleus, nucleolus
1 PDB 3D structure from  and Proteopedia  for RBM4B:2DGT (3D)
Secondary accessions: B3KT83Explore the universe of human proteins at neXtProt for RBM4B: NX_Q9BQ04
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BQ04
RBM4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_113680.1
ENSEMBL proteins: ENSP00000433071 ENSP00000310471 ENSP00000435239 ENSP00000433601 ENSP00000433113
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
RBM4B for ontologies About GeneDecksing
RBM4B Antibody Products:
Assay Products for RBM4B: |
Protein
Domains /
Families
for RBM4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM4B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BQ04ProtoNet protein and cluster: Q9BQ04 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB001878 C2HC-type zinc-finger signature
UniProtKB/Swiss-Prot: RBM4B_HUMAN, Q9BQ04Similarity: Contains 1 CCHC-type zinc fingerSimilarity: Contains 2 RRM (RNA recognition motif) domains |
Function
for RBM4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBM4B_HUMAN, Q9BQ04Function: Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the3'-UTR of the PER1 mRNA (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: RBM4B (NM_031492) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM4B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM4B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM4B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RBM4B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RBM4B:
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Pathways & Interactions
for RBM4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM4B
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/10 Interacting proteins for RBM4B (Q9BQ042, 3 ENSP000003104714) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
RBM4B for ontologies About GeneDecksing
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Drugs & Compounds
for RBM4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM4B
Search CenterWatch for drugs/clinical trials and news about RBM4B
|
Transcripts
for RBM4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM4B gene: NM_031492.2 Unigene Cluster for RBM4B: RNA binding motif protein 4B Hs.618713 [show with all ESTs]Unigene Representative Sequence: AK0951588 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000525754(uc001oja.3) ENST00000310046(uc001ojb.3) ENST00000531969
ENST00000534198 ENST00000528106 ENST00000529195 ENST00000524637 ENST00000531036
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBM4B (NM_031492) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM4B |
Additional cDNA sequence: AK095158.1 AL050172.1 BC003503.1 BC004951.1 16 DOTS entries: DT.100653463 DT.452822 DT.100645691 DT.65287805 DT.95365132 DT.91911756 DT.307590 DT.99980711 DT.120685127 DT.91764529 DT.95225754 DT.95364673 DT.119624 DT.452733 DT.75169450 DT.91678764 24/190 AceView cDNA sequences (see all 190): AI129555 AI927433 BM750086 BI908139 AW964128 AA602099 BQ186191 AA722657 AA578575 AK095158 AI273604 BP872185 AI651442 AW135730 BE328092 AI929021 CB069819 AA908776 AI351019 BU543030 AL050172 BM981663 BQ939871 NM_031492
GeneLoc Exon Structure
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Expression
for RBM4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTGGCAAG
About this image
See RBM4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM4B
SOURCE GeneReport for Unigene cluster: Hs.618713
UniProtKB/Swiss-Prot: RBM4B_HUMAN, Q9BQ04Tissue specificity: Expressed in liver and kidney (at protein level). Ubiquitously expressed
SABiosciences Custom PCR Arrays for RBM4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBM4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM4B |
Orthologs
for RBM4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RBM4B gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for RBM4B (if available)
TreeFam Gene Tree for RBM4B (if available) |
Paralogs
for RBM4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBM4B gene
- RBM42 RBM14-RBM42 RBM142
18/19 SIMAP similar genes for RBM4B using alignment to 4 protein entries: RBM4B_HUMAN (see all proteins)
(see all similar genes):RBM4 RBM14/RBM4 fusion CELF3 RBM14 SRSF5 SFRS5
CELF1 RBM14-RBM4 HNRNPD NONO SFPQ CELF2
ELAVL4 DAZAP1 ELAVL2 CELF4 PABPC3 TIA1
RBM4B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RBM4B
PGOHUM00000249447
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Genomic Variants
for RBM4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBM4B (66432469 - 66445392 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBM4B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM4B |
|
Disorders
/ Diseases
for RBM4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBM4B for disorders About GeneDecksing
1  disease for RBM4B: About MalaCardsdown syndrome
Export disorders for RBM4B gene to outside databases
|
Publications
for RBM4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM4B gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with RBM4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A novel splicing regulator shares a nuclear import pathway with SR proteins. (PubMed id 12628928)1, 2 Lai M.-C.... Tarn W.-Y. (2003)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for RBM4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RBM4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBM4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBM4B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBM4B gene:
Search GeneIP for patents involving RBM4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RBM4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM4B | | | OriGene Protein Over-expression Lysate for RBM4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBM4B | | OriGene 3'-UTR Clone for RBM4B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RBM4B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBM4B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBM4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM4B |
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 | | | RBM4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM4B |
|  |  |  | | | | Search ThermoFisher Antibodies for RBM4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM4B |
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