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Aliases for RBM4B Gene

Aliases for RBM4B Gene

  • RNA Binding Motif Protein 4B 2 3 5
  • RNA-Binding Motif Protein 30 3 4
  • RBM30 3 4
  • Zinc Finger CCHC-Type And RNA Binding Motif 3B 3
  • RNA Binding Motif Protein 30 2
  • RNA-Binding Motif Protein 4B 4
  • RNA-Binding Protein 4B 3
  • RNA-Binding Protein 30 4
  • ZCCHC21B 3
  • ZCCHC15 3
  • ZCRB3B 3
  • RBM4L 3

External Ids for RBM4B Gene

Previous HGNC Symbols for RBM4B Gene

  • RBM30

Previous GeneCards Identifiers for RBM4B Gene

  • GC11M066190
  • GC11M066432
  • GC11M062761

Summaries for RBM4B Gene

GeneCards Summary for RBM4B Gene

RBM4B (RNA Binding Motif Protein 4B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM4.

UniProtKB/Swiss-Prot for RBM4B Gene

  • Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3-UTR of the PER1 mRNA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM4B Gene

Genomics for RBM4B Gene

Regulatory Elements for RBM4B Gene

Enhancers for RBM4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F066422 1.2 ENCODE 41.6 +256.0 255995 0.8 CREB3L1 MLX ZFP64 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D RBM4B LOC105369353 RBM14 ENSG00000258297 CLCF1 MUS81 SSSCA1-AS1 KLC2 KAT5 EIF1AD
GH11F067579 0.7 Ensembl ENCODE 24.2 -906.3 -906308 10.5 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ENSG00000255119 NUDT8 PTPRCAP RBM4B NDUFV1 ENSG00000258297 C11orf72 DOC2GP TBX10 ENSG00000255318
GH11F067350 1.3 FANTOM5 ENCODE 23.3 -676.8 -676811 7.8 ZFP64 YBX1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 GLIS1 ENSG00000258297 RBM14 RCE1 SSH3 RAD9A RBM4B FAM86C2P MRPL11 ANKRD13D CLCF1
GH11F066342 1.5 FANTOM5 Ensembl ENCODE 21.8 +329.4 329377 11.8 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ENSG00000258297 RBM14 RIN1 MRPL11 SSSCA1-AS1 EIF1AD RCE1 LOC105369352 CD248 ACTN3
GH11F067116 0.2 ENCODE 13.8 -441.8 -441783 5.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 SP3 REST TBX21 ENSG00000258297 LOC105369352 RBM14 LOC105369353 ENSG00000245156 RCE1 RAD9A ENSG00000255320 SSH3 FAM86C2P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBM4B on UCSC Golden Path with GeneCards custom track

Promoters for RBM4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RBM4B Gene

66,664,994 bp from pter
66,677,921 bp from pter
12,928 bases
Minus strand

Genomic View for RBM4B Gene

Genes around RBM4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM4B Gene

Proteins for RBM4B Gene

  • Protein details for RBM4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 4B
    Protein Accession:
    Secondary Accessions:
    • B3KT83

    Protein attributes for RBM4B Gene

    359 amino acids
    Molecular mass:
    40150 Da
    Quaternary structure:
    • Interacts with TNPO3, which may mediate nuclear import of the protein.

    Three dimensional structures from OCA and Proteopedia for RBM4B Gene

neXtProt entry for RBM4B Gene

Post-translational modifications for RBM4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM4B Gene

Domains & Families for RBM4B Gene

Suggested Antigen Peptide Sequences for RBM4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RRM (RNA recognition motif) domains.
  • Contains 1 CCHC-type zinc finger.
  • Contains 2 RRM (RNA recognition motif) domains.
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with RBM4B: view

Function for RBM4B Gene

Molecular function for RBM4B Gene

UniProtKB/Swiss-Prot Function:
Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3-UTR of the PER1 mRNA (By similarity).

Gene Ontology (GO) - Molecular Function for RBM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 23455924
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RBM4B: view
genes like me logo Genes that share phenotypes with RBM4B: view

Animal Models for RBM4B Gene

MGI Knock Outs for RBM4B:

Animal Model Products

miRNA for RBM4B Gene

miRTarBase miRNAs that target RBM4B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBM4B Gene

Localization for RBM4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM4B Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RBM4B Gene COMPARTMENTS Subcellular localization image for RBM4B gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with RBM4B: view

Pathways & Interactions for RBM4B Gene

SuperPathways for RBM4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006417 regulation of translation ISS --
GO:0007623 circadian rhythm ISS --
GO:0008380 RNA splicing IEA --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with RBM4B: view

No data available for Pathways by source and SIGNOR curated interactions for RBM4B Gene

Transcripts for RBM4B Gene

Unigene Clusters for RBM4B Gene

RNA binding motif protein 4B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM4B Gene

No ASD Table

Relevant External Links for RBM4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM4B Gene

Protein differential expression in normal tissues from HIPED for RBM4B Gene

This gene is overexpressed in Bone (16.8), Peripheral blood mononuclear cells (15.7), Lung (9.5), and Cervix (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM4B Gene

Protein tissue co-expression partners for RBM4B Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM4B Gene:


SOURCE GeneReport for Unigene cluster for RBM4B Gene:


mRNA Expression by UniProt/SwissProt for RBM4B Gene:

Tissue specificity: Expressed in liver and kidney (at protein level). Ubiquitously expressed.
genes like me logo Genes that share expression patterns with RBM4B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBM4B Gene

Orthologs for RBM4B Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM4B 34 35
  • 99.16 (n)
(Canis familiaris)
Mammalia RBM4B 34 35
  • 93.59 (n)
(Bos Taurus)
Mammalia RBM4B 34 35
  • 92.48 (n)
(Mus musculus)
Mammalia Rbm4b 34 16 35
  • 89.54 (n)
(Rattus norvegicus)
Mammalia Rbm4b 34
  • 89.54 (n)
(Ornithorhynchus anatinus)
Mammalia RBM4B 35
  • 74 (a)
(Gallus gallus)
Aves -- 35
  • 92 (a)
LOC100859276 34
  • 62.02 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm4b 34
  • 58.41 (n)
MGC75893 34
(Danio rerio)
Actinopterygii rbm4.1 34 35
  • 61.6 (n)
rbm4.2 35
  • 46 (a)
rbm4.3 35
  • 43 (a)
wufc25a01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10235 34
fruit fly
(Drosophila melanogaster)
Insecta lark 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea rnp-1 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
Species where no ortholog for RBM4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM4B Gene

Gene Tree for RBM4B (if available)
Gene Tree for RBM4B (if available)

Paralogs for RBM4B Gene

Paralogs for RBM4B Gene

(14) SIMAP similar genes for RBM4B Gene using alignment to 5 proteins: Pseudogenes for RBM4B Gene

genes like me logo Genes that share paralogs with RBM4B: view

Variants for RBM4B Gene

Sequence variations from dbSNP and Humsavar for RBM4B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111334132 -- 66,676,708(+) TCCAC(C/G/T)GCATC nc-transcript-variant, reference, synonymous-codon
rs111758252 -- 66,672,504(+) TTTTT(C/T)TGGGG intron-variant
rs111896078 -- 66,673,677(+) TAGTC(C/T)TGAAC intron-variant
rs111989717 -- 66,678,720(+) TGCGG(C/T)GGCTC upstream-variant-2KB
rs112218567 -- 66,672,506(+) TTTTT(G/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM4B Gene

Variant ID Type Subtype PubMed ID
nsv518919 CNV loss 19592680
nsv522277 CNV loss 19592680
nsv975197 CNV duplication 23825009

Variation tolerance for RBM4B Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM4B Gene

Disorders for RBM4B Gene

Relevant External Links for RBM4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RBM4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM4B Gene

Publications for RBM4B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A novel splicing regulator shares a nuclear import pathway with SR proteins. (PMID: 12628928) Lai M.-C. … Tarn W.-Y. (EMBO J. 2003) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64

Products for RBM4B Gene

Sources for RBM4B Gene

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