Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBM47 Gene

Aliases for RBM47 Gene

  • RNA Binding Motif Protein 47 2 3 5
  • RNA-Binding Motif Protein 47 4
  • RNA-Binding Protein 47 3
  • NET18 3

External Ids for RBM47 Gene

Previous GeneCards Identifiers for RBM47 Gene

  • GC04M040121
  • GC04M039747

Summaries for RBM47 Gene

GeneCards Summary for RBM47 Gene

RBM47 (RNA Binding Motif Protein 47) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is A1CF.

Additional gene information for RBM47 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM47 Gene

Genomics for RBM47 Gene

Regulatory Elements for RBM47 Gene

Enhancers for RBM47 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H040572 2 FANTOM5 Ensembl ENCODE dbSUPER 24.8 +54.3 54252 8 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 RBM47 PDS5A N4BP2 CHRNA9 ENSG00000250906 RNU7-74P NSUN7 MIR4802
GH04H040721 1.6 FANTOM5 Ensembl ENCODE dbSUPER 25.2 -91.9 -91887 2 HDGF FOXA2 TAL1 ETV1 ZNF175 ZBTB40 BATF CTBP1 POLR2A FOS RBM47 ENSG00000250906 CHRNA9 RNU7-74P NSUN7 GC04P040643
GH04H040585 1.6 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +42.8 42847 5 SMARCE1 CEBPB MAX MNT DPF2 RAD21 YY1 JUND GATA3 FOS RBM47 CHRNA9 MIR4802
GH04H040670 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.2 -41.7 -41681 3 ATF1 ZNF766 FOS ATF7 RUNX3 JUNB KAT8 MAFF ETV4 STAT3 RBM47 GC04P040643 NSUN7
GH04H040557 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.3 +68.8 68800 9 BATF RAD21 RARA YY1 FOS ATF7 RUNX3 CREM IKZF2 CEBPB RBM47 CHRNA9 MIR4802
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM47 on UCSC Golden Path with GeneCards custom track

Promoters for RBM47 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167758 1875 4001 PKNOX1 YY1 ETS1 GLIS2 ZNF207 FOS RUNX3 SP3 JUNB REST

Genomic Location for RBM47 Gene

Chromosome:
4
Start:
40,423,255 bp from pter
End:
40,630,875 bp from pter
Size:
207,621 bases
Orientation:
Minus strand

Genomic View for RBM47 Gene

Genes around RBM47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM47 Gene

Proteins for RBM47 Gene

  • Protein details for RBM47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AV96-RBM47_HUMAN
    Recommended name:
    RNA-binding protein 47
    Protein Accession:
    A0AV96
    Secondary Accessions:
    • A0PJK2
    • B5MED4
    • Q8NI52
    • Q8NI53
    • Q9NXG3

    Protein attributes for RBM47 Gene

    Size:
    593 amino acids
    Molecular mass:
    64099 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM21973.1; Type=Frameshift; Positions=561, 577; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM47 Gene

    Alternative splice isoforms for RBM47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM47 Gene

Post-translational modifications for RBM47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM47 Gene

Domains & Families for RBM47 Gene

Gene Families for RBM47 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM47 Gene

Graphical View of Domain Structure for InterPro Entry

A0AV96

UniProtKB/Swiss-Prot:

RBM47_HUMAN :
  • Belongs to the RRM RBM47 family.
Family:
  • Belongs to the RRM RBM47 family.
genes like me logo Genes that share domains with RBM47: view

Function for RBM47 Gene

Phenotypes From GWAS Catalog for RBM47 Gene

Gene Ontology (GO) - Molecular Function for RBM47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
genes like me logo Genes that share ontologies with RBM47: view
genes like me logo Genes that share phenotypes with RBM47: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBM47
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM47 Gene

Localization for RBM47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM47 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM47 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBM47: view

Pathways & Interactions for RBM47 Gene

SuperPathways for RBM47 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0016554 cytidine to uridine editing IEA --
genes like me logo Genes that share ontologies with RBM47: view

No data available for Pathways by source and SIGNOR curated interactions for RBM47 Gene

Drugs & Compounds for RBM47 Gene

No Compound Related Data Available

Transcripts for RBM47 Gene

Unigene Clusters for RBM47 Gene

RNA binding motif protein 47:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBM47
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RBM47 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9
SP1: - - - - -
SP2: -
SP3: - -
SP4: -
SP5:
SP6: -

Relevant External Links for RBM47 Gene

GeneLoc Exon Structure for
RBM47
ECgene alternative splicing isoforms for
RBM47

Expression for RBM47 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBM47 Gene

This gene is overexpressed in Colon - Transverse (x4.9), Adrenal Gland (x4.5), and Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for RBM47 Gene

This gene is overexpressed in Cervix (17.2) and Salivary gland (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM47 Gene



Protein tissue co-expression partners for RBM47 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM47 Gene:

RBM47

SOURCE GeneReport for Unigene cluster for RBM47 Gene:

Hs.518727

Evidence on tissue expression from TISSUES for RBM47 Gene

  • Lung(4.4)
  • Nervous system(4.1)
  • Kidney(2.8)
genes like me logo Genes that share expression patterns with RBM47: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM47 Gene

Orthologs for RBM47 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM47 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia DKFZP686F02235 34
  • 98 (a)
OneToOne
RBM47 33
  • 92.02 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RBM47 33 34
  • 91.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RBM47 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm47 33 16 34
  • 87.41 (n)
rat
(Rattus norvegicus)
Mammalia Rbm47 33
  • 86.62 (n)
chicken
(Gallus gallus)
Aves RBM47 33 34
  • 80.17 (n)
lizard
(Anolis carolinensis)
Reptilia RBM47 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm47 33
  • 70.63 (n)
zebrafish
(Danio rerio)
Actinopterygii RBM47 34
  • 78 (a)
OneToOne
rbm47 33
  • 73.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17838 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
Species where no ortholog for RBM47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM47 Gene

ENSEMBL:
Gene Tree for RBM47 (if available)
TreeFam:
Gene Tree for RBM47 (if available)

Paralogs for RBM47 Gene

Paralogs for RBM47 Gene

genes like me logo Genes that share paralogs with RBM47: view

Variants for RBM47 Gene

Sequence variations from dbSNP and Humsavar for RBM47 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000001446 -- 40,472,546(+) AACAA(A/G)AGTGA intron-variant
rs1000003745 -- 40,632,038(+) GGTAT(C/G/T)AAGAA upstream-variant-2KB
rs1000028296 -- 40,472,502(+) GGTTG(C/T)AGTAA intron-variant
rs10000300 -- 40,464,530(+) atttt(G/T)ggaat intron-variant
rs1000043007 -- 40,427,887(+) GATAA(C/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM47 Gene

Variant ID Type Subtype PubMed ID
dgv935e199 CNV deletion 23128226
dgv936e199 CNV deletion 23128226
esv2661897 CNV deletion 23128226
esv2759248 CNV loss 17122850
esv3563750 CNV deletion 23714750
esv3569394 CNV loss 25503493
esv3600305 CNV loss 21293372
esv3600306 CNV loss 21293372
esv3600307 CNV loss 21293372
esv3600309 CNV loss 21293372
esv3600310 CNV loss 21293372
esv3600311 CNV loss 21293372
esv3600312 CNV loss 21293372
esv3600313 CNV loss 21293372
nsv10482 CNV loss 18304495
nsv10484 CNV loss 18304495
nsv1071974 CNV deletion 25765185
nsv1117074 CNV deletion 24896259
nsv829910 CNV loss 17160897
nsv997983 CNV gain 25217958

Variation tolerance for RBM47 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM47 Gene

Disorders for RBM47 Gene

Relevant External Links for RBM47

Genetic Association Database (GAD)
RBM47
Human Genome Epidemiology (HuGE) Navigator
RBM47
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM47

No disorders were found for RBM47 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM47 Gene

Publications for RBM47 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma. (PMID: 26923328) Sakurai T … Koinuma D (Oncogene 2016) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. (PMID: 24898756) Vanharanta S … Massagué J (eLife 2014) 3 60

Products for RBM47 Gene

Sources for RBM47 Gene

Content
Loading form....