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Aliases for RBM46 Gene

Aliases for RBM46 Gene

  • RNA Binding Motif Protein 46 2 3 5
  • Cancer/Testis Antigen 68 2 3 4
  • CT68 3 4
  • Probable RNA-Binding Protein 46 3
  • RNA-Binding Motif Protein 46 4

External Ids for RBM46 Gene

Previous GeneCards Identifiers for RBM46 Gene

  • GC04P155922
  • GC04P155702
  • GC04P151443

Summaries for RBM46 Gene

GeneCards Summary for RBM46 Gene

RBM46 (RNA Binding Motif Protein 46) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is A1CF.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM46 Gene

Genomics for RBM46 Gene

Regulatory Elements for RBM46 Gene

Enhancers for RBM46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F154738 0.6 ENCODE 11.3 -42.4 -42442 1.3 MTA2 IKZF1 HLF RBM46 LOC105377500 LRAT GC04M154737 GC04P154736
GH04F154742 0.2 ENCODE 11 -38.5 -38540 0.2 MYC EZH2 LOC105377500 RBM46 LRAT FGG PIR52192 PIR56291
GH04F154740 0.5 ENCODE 11 -39.5 -39498 1.5 PKNOX1 SMARCA4 NFE2 MYC EZH2 RBM46 LOC105377500 LRAT FGG GC04M154758 PIR47588 PIR56291
GH04F154718 1.2 ENCODE 10.6 -60.7 -60702 4.2 HDGF CTCF PKNOX1 JUN TEAD4 ZNF175 POLR2A TRIM24 ZNF584 MAFK LRAT RBM46 LOC105377500 NDUFB2P1 PIR53599
GH04F154683 0.2 ENCODE 10.5 -97.0 -96957 1.3 JUND HNF4G FOS MAFK LOC105377500 RBM46 GC04M154691 LRAT
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBM46 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM46 Gene

154,781,213 bp from pter
154,828,813 bp from pter
47,601 bases
Plus strand

Genomic View for RBM46 Gene

Genes around RBM46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM46 Gene

Proteins for RBM46 Gene

  • Protein details for RBM46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable RNA-binding protein 46
    Protein Accession:
    Secondary Accessions:
    • B3KWU8
    • B4DZ27

    Protein attributes for RBM46 Gene

    533 amino acids
    Molecular mass:
    60023 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RBM46 Gene


neXtProt entry for RBM46 Gene

Post-translational modifications for RBM46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM46 Gene

Domains & Families for RBM46 Gene

Gene Families for RBM46 Gene

Suggested Antigen Peptide Sequences for RBM46 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 RRM (RNA recognition motif) domains.
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBM46: view

Function for RBM46 Gene

Gene Ontology (GO) - Molecular Function for RBM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBM46: view
genes like me logo Genes that share phenotypes with RBM46: view

Animal Model Products

miRNA for RBM46 Gene

miRTarBase miRNAs that target RBM46

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM46 Gene

Localization for RBM46 Gene

Subcellular locations from

Jensen Localization Image for RBM46 Gene COMPARTMENTS Subcellular localization image for RBM46 gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM46 Gene

Pathways & Interactions for RBM46 Gene

SuperPathways for RBM46 Gene

No Data Available

Interacting Proteins for RBM46 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)
Selected Interacting proteins: ENSP00000281722 Q8TBY0-RBM46_HUMAN for RBM46 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RBM46 Gene


No data available for Pathways by source and SIGNOR curated interactions for RBM46 Gene

Transcripts for RBM46 Gene

Unigene Clusters for RBM46 Gene

RNA binding motif protein 46:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM46 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - -

Relevant External Links for RBM46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM46 Gene

mRNA expression in normal human tissues for RBM46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBM46 Gene

This gene is overexpressed in Testis (x43.2).

Protein differential expression in normal tissues from HIPED for RBM46 Gene

This gene is overexpressed in Cervix (28.9), Testis (28.5), and Pancreatic juice (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM46 Gene

Protein tissue co-expression partners for RBM46 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM46 Gene:


SOURCE GeneReport for Unigene cluster for RBM46 Gene:

genes like me logo Genes that share expression patterns with RBM46: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RBM46 Gene

Orthologs for RBM46 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM46 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM46 34 35
  • 99.5 (n)
(Canis familiaris)
Mammalia RBM46 34 35
  • 95.62 (n)
(Bos Taurus)
Mammalia RBM46 34 35
  • 94.5 (n)
(Rattus norvegicus)
Mammalia Rbm46 34
  • 91.62 (n)
(Mus musculus)
Mammalia Rbm46 34 16 35
  • 90.46 (n)
(Monodelphis domestica)
Mammalia RBM46 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RBM46 35
  • 88 (a)
(Gallus gallus)
Aves RBM46 34 35
  • 79.13 (n)
(Anolis carolinensis)
Reptilia RBM46 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498620 34
  • 75.27 (n)
Str.19533 34
(Danio rerio)
Actinopterygii rbm46 34 35
  • 64.06 (n)
wufe11d09 34
fruit fly
(Drosophila melanogaster)
Insecta CG17838 35
  • 25 (a)
(Caenorhabditis elegans)
Secernentea hrp-2 35
  • 26 (a)
Species where no ortholog for RBM46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM46 Gene

Gene Tree for RBM46 (if available)
Gene Tree for RBM46 (if available)

Paralogs for RBM46 Gene

Paralogs for RBM46 Gene

(7) SIMAP similar genes for RBM46 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBM46: view

Variants for RBM46 Gene

Sequence variations from dbSNP and Humsavar for RBM46 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10017337 -- 154,794,432(+) gcctc(A/G)gcctc intron-variant, upstream-variant-2KB
rs10021359 -- 154,783,436(+) TGACT(A/G)CAAAT intron-variant, upstream-variant-2KB
rs10029776 -- 154,789,395(+) ttgaa(C/T)tttgt intron-variant
rs10517603 -- 154,822,050(+) CCAAA(G/T)ACACA intron-variant
rs10644795 -- 154,809,067(+) TAGAT(-/AGAC)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM46 Gene

Variant ID Type Subtype PubMed ID
nsv820098 CNV gain 19587683

Variation tolerance for RBM46 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM46 Gene

Disorders for RBM46 Gene

Relevant External Links for RBM46

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RBM46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM46 Gene

Publications for RBM46 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  4. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 46 64
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 46 64

Products for RBM46 Gene

Sources for RBM46 Gene

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