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Aliases for RBM46 Gene

Aliases for RBM46 Gene

  • RNA Binding Motif Protein 46 2 3 5
  • Cancer/Testis Antigen 68 2 3 4
  • CT68 3 4
  • Probable RNA-Binding Protein 46 3
  • RNA-Binding Motif Protein 46 4

External Ids for RBM46 Gene

Previous GeneCards Identifiers for RBM46 Gene

  • GC04P155922
  • GC04P155702
  • GC04P151443

Summaries for RBM46 Gene

GeneCards Summary for RBM46 Gene

RBM46 (RNA Binding Motif Protein 46) is a Protein Coding gene. Diseases associated with RBM46 include Basal Cell Nevus Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is A1CF.

Additional gene information for RBM46 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM46 Gene

Genomics for RBM46 Gene

GeneHancer (GH) Regulatory Elements for RBM46 Gene

Promoters and enhancers for RBM46 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I154781 Promoter 0.6 EPDnew 550.8 +0.0 22 0.1 PKNOX1 LOC105377500 RBM46
GH04I154718 Enhancer 0.9 ENCODE dbSUPER 10.7 -60.7 -60701 4.2 CTCF JUN ETV1 CEBPG IRF9 FOSL1 POLR2A ZNF143 ATF7 TRIM24 LRAT LOC105377500 RBM46 NDUFB2P1 PIR53599
GH04I154741 Promoter 0.7 EPDnew 11 -40.4 -40394 0.1 SIN3A EZH2 LRAT GC04M154737 GC04M154751 GC04M154753 GC04M154758 PIR47588 PIR31824 PIR56291 PIR52192 PIR61545
GH04I154740 Enhancer 0.6 Ensembl ENCODE 11 -39.2 -39229 2 POU5F1 SIN3A EZH2 GC04M154751 GC04M154753 GC04M154774 PIR47588 PIR31824 PIR56291 PIR52192 PIR61545 PIR62406 GC04M154758
GH04I154738 Enhancer 0.4 ENCODE dbSUPER 11.3 -42.4 -42441 1.3 GC04M154737 GC04P154736 PIR61545 LOC105377500 RBM46 LRAT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBM46 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM46 gene promoter:

Genomic Locations for RBM46 Gene

Genomic Locations for RBM46 Gene
chr4:154,781,213-154,828,813
(GRCh38/hg38)
Size:
47,601 bases
Orientation:
Plus strand
chr4:155,702,365-155,749,965
(GRCh37/hg19)

Genomic View for RBM46 Gene

Genes around RBM46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM46 Gene

Proteins for RBM46 Gene

  • Protein details for RBM46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBY0-RBM46_HUMAN
    Recommended name:
    Probable RNA-binding protein 46
    Protein Accession:
    Q8TBY0
    Secondary Accessions:
    • B3KWU8
    • B4DZ27

    Protein attributes for RBM46 Gene

    Size:
    533 amino acids
    Molecular mass:
    60023 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RBM46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM46 Gene

Post-translational modifications for RBM46 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RBM46 Gene

Domains & Families for RBM46 Gene

Gene Families for RBM46 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RBM46 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM46: view

No data available for UniProtKB/Swiss-Prot for RBM46 Gene

Function for RBM46 Gene

Phenotypes From GWAS Catalog for RBM46 Gene

Gene Ontology (GO) - Molecular Function for RBM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBM46: view
genes like me logo Genes that share phenotypes with RBM46: view

miRNA for RBM46 Gene

miRTarBase miRNAs that target RBM46

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM46 Gene

Localization for RBM46 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM46 gene
Compartment Confidence
nucleus 4
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RBM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBM46: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RBM46 Gene

Pathways & Interactions for RBM46 Gene

SuperPathways for RBM46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001829 trophectodermal cell differentiation IEA --
GO:0048255 mRNA stabilization IEA --
genes like me logo Genes that share ontologies with RBM46: view

No data available for Pathways by source and SIGNOR curated interactions for RBM46 Gene

Drugs & Compounds for RBM46 Gene

No Compound Related Data Available

Transcripts for RBM46 Gene

Unigene Clusters for RBM46 Gene

RNA binding motif protein 46:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM46 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3:
SP4:

Relevant External Links for RBM46 Gene

GeneLoc Exon Structure for
RBM46
ECgene alternative splicing isoforms for
RBM46

Expression for RBM46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBM46 Gene

This gene is overexpressed in Testis (x43.2).

Protein differential expression in normal tissues from HIPED for RBM46 Gene

This gene is overexpressed in Cervix (28.9), Testis (28.5), and Pancreatic juice (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM46 Gene



Protein tissue co-expression partners for RBM46 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM46 Gene:

RBM46

SOURCE GeneReport for Unigene cluster for RBM46 Gene:

Hs.133095
genes like me logo Genes that share expression patterns with RBM46: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM46 Gene

Orthologs for RBM46 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM46 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia RBM46 33 34
  • 95.62 (n)
cow
(Bos Taurus)
Mammalia RBM46 33 34
  • 94.5 (n)
rat
(Rattus norvegicus)
Mammalia Rbm46 33
  • 91.62 (n)
mouse
(Mus musculus)
Mammalia Rbm46 33 16 34
  • 90.46 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM46 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM46 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM46 33 34
  • 79.13 (n)
lizard
(Anolis carolinensis)
Reptilia RBM46 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498620 33
  • 75.27 (n)
Str.19533 33
zebrafish
(Danio rerio)
Actinopterygii rbm46 33 34
  • 64.06 (n)
wufe11d09 33
fruit fly
(Drosophila melanogaster)
Insecta CG17838 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 34
  • 26 (a)
OneToMany
Species where no ortholog for RBM46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM46 Gene

ENSEMBL:
Gene Tree for RBM46 (if available)
TreeFam:
Gene Tree for RBM46 (if available)

Paralogs for RBM46 Gene

Paralogs for RBM46 Gene

(7) SIMAP similar genes for RBM46 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBM46: view

Variants for RBM46 Gene

Sequence variations from dbSNP and Humsavar for RBM46 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000059366 -- 154,808,517(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000195355 -- 154,826,305(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000207281 -- 154,802,767(+) T/G intron_variant
rs1000284168 -- 154,782,584(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000349626 -- 154,794,257(+) T/ genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM46 Gene

Variant ID Type Subtype PubMed ID
nsv820098 CNV gain 19587683

Variation tolerance for RBM46 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM46 Gene

Disorders for RBM46 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBM46 Gene - From: DISEASES

Disorder Aliases PubMed IDs
basal cell nevus syndrome
  • bcns
- elite association - COSMIC cancer census association via MalaCards
Search RBM46 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RBM46

genes like me logo Genes that share disorders with RBM46: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM46 Gene

Publications for RBM46 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  4. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 44 58
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 44 58

Products for RBM46 Gene

Sources for RBM46 Gene

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