Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBM45 Gene

Aliases for RBM45 Gene

  • RNA Binding Motif Protein 45 2 3
  • Developmentally-Regulated RNA-Binding Protein 1 3 4
  • RNA-Binding Motif Protein 45 3 4
  • DRB1 3 4
  • RB-1 3 4
  • Developmentally Regulated RNA Binding Protein 1 2
  • Developmentally Regulated RNA-Binding Protein 1 3
  • Putative RNA Binding Protein RB-1 3
  • RNA-Binding Protein 45 3
  • DRBP1 4

External Ids for RBM45 Gene

Previous GeneCards Identifiers for RBM45 Gene

  • GC02P178686
  • GC02P178977
  • GC02P170847

Summaries for RBM45 Gene

Entrez Gene Summary for RBM45 Gene

  • This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

GeneCards Summary for RBM45 Gene

RBM45 (RNA Binding Motif Protein 45) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for RBM45 Gene

  • RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM45 Gene

Genomics for RBM45 Gene

Regulatory Elements for RBM45 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBM45 Gene

Start:
178,112,422 bp from pter
End:
178,139,011 bp from pter
Size:
26,590 bases
Orientation:
Plus strand

Genomic View for RBM45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM45 Gene

Proteins for RBM45 Gene

  • Protein details for RBM45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH3-RBM45_HUMAN
    Recommended name:
    RNA-binding protein 45
    Protein Accession:
    Q8IUH3
    Secondary Accessions:
    • Q6NYL0
    • Q8NFC9

    Protein attributes for RBM45 Gene

    Size:
    476 amino acids
    Molecular mass:
    53502 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RBM45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM45 Gene

Proteomics data for RBM45 Gene at MOPED

Post-translational modifications for RBM45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM45 Gene

No data available for DME Specific Peptides for RBM45 Gene

Domains for RBM45 Gene

Gene Families for RBM45 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBM45 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RBM45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUH3

UniProtKB/Swiss-Prot:

RBM45_HUMAN :
  • Q8IUH3
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBM45: view

Function for RBM45 Gene

Molecular function for RBM45 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

Gene Ontology (GO) - Molecular Function for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 12220514
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM45: view
genes like me logo Genes that share phenotypes with RBM45: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM45

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RBM45 Gene

Localization for RBM45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM45 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM45 Gene COMPARTMENTS Subcellular localization image for RBM45 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 12220514
genes like me logo Genes that share ontologies with RBM45: view

Pathways for RBM45 Gene

SuperPathways for RBM45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RBM45: view

No data available for Pathways by source for RBM45 Gene

Transcripts for RBM45 Gene

Unigene Clusters for RBM45 Gene

RNA binding motif protein 45:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM45

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RBM45

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: -

Relevant External Links for RBM45 Gene

GeneLoc Exon Structure for
RBM45
ECgene alternative splicing isoforms for
RBM45

Expression for RBM45 Gene

mRNA expression in normal human tissues for RBM45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM45 Gene

SOURCE GeneReport for Unigene cluster for RBM45 Gene Hs.377257

genes like me logo Genes that share expressions with RBM45: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM45 Gene

Orthologs for RBM45 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM45 35
  • 99.86 (n)
  • 100 (a)
RBM45 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM45 35
  • 93.46 (n)
  • 95.99 (a)
RBM45 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM45 35
  • 93.67 (n)
  • 97.47 (a)
RBM45 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm45 35
  • 86.36 (n)
  • 90.51 (a)
Rbm45 16
Rbm45 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM45 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM45 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm45 35
  • 85.86 (n)
  • 91.56 (a)
chicken
(Gallus gallus)
Aves RBM45 35
  • 74.79 (n)
  • 71.58 (a)
RBM45 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia drbp1-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm45 35
  • 68.34 (n)
  • 70.52 (a)
Str.2753 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1796 35
zebrafish
(Danio rerio)
Actinopterygii rbm45 35
  • 62.97 (n)
  • 64.3 (a)
rbm45 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005505 35
  • 44.52 (n)
  • 40.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1316 35
  • 49.57 (n)
  • 40.71 (a)
CG1316 36
  • 37 (a)
OneToOne
Species with no ortholog for RBM45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBM45 Gene

ENSEMBL:
Gene Tree for RBM45 (if available)
TreeFam:
Gene Tree for RBM45 (if available)

Paralogs for RBM45 Gene

No data available for Paralogs for RBM45 Gene

Variants for RBM45 Gene

Sequence variations from dbSNP and Humsavar for RBM45 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15515 -- 178,129,481(-) AAAAA(A/G)AAGCT utr-variant-3-prime
rs334055 -- 178,129,752(+) GATGC(A/G)CATCT downstream-variant-500B
rs334056 -- 178,129,821(+) gtaat(C/T)gacaa downstream-variant-500B
rs930192 -- 178,129,461(+) ATTCC(A/C)TGTGG utr-variant-3-prime
rs1025446 -- 178,120,042(+) GGGAA(A/G)GGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM45 Gene

Variant ID Type Subtype PubMed ID
nsv518790 CNV Gain 19592680
nsv875452 CNV Gain 21882294

Relevant External Links for RBM45 Gene

HapMap Linkage Disequilibrium report
RBM45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM45 Gene

Disorders for RBM45 Gene

No disorders were found for RBM45 Gene.

No data available for UniProtKB/Swiss-Prot for RBM45 Gene

Publications for RBM45 Gene

  1. cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. (PMID: 12220514) Tamada H. … Endo H. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for RBM45 Gene

Sources for RBM45 Gene

Back to Top

Content