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Aliases for RBM45 Gene

Aliases for RBM45 Gene

  • RNA Binding Motif Protein 45 2 3 5
  • Developmentally-Regulated RNA-Binding Protein 1 3 4
  • RNA-Binding Motif Protein 45 3 4
  • DRB1 3 4
  • RB-1 3 4
  • Developmentally Regulated RNA Binding Protein 1 2
  • Developmentally Regulated RNA-Binding Protein 1 3
  • Putative RNA Binding Protein RB-1 3
  • DRBP1 4

External Ids for RBM45 Gene

Previous GeneCards Identifiers for RBM45 Gene

  • GC02P178686
  • GC02P178977
  • GC02P170847

Summaries for RBM45 Gene

Entrez Gene Summary for RBM45 Gene

  • This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

GeneCards Summary for RBM45 Gene

RBM45 (RNA Binding Motif Protein 45) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for RBM45 Gene

  • RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM45 Gene

Genomics for RBM45 Gene

Regulatory Elements for RBM45 Gene

Promoters for RBM45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM45 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM45 Gene

Chromosome:
2
Start:
178,112,417 bp from pter
End:
178,139,011 bp from pter
Size:
26,595 bases
Orientation:
Plus strand

Genomic View for RBM45 Gene

Genes around RBM45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM45 Gene

Proteins for RBM45 Gene

  • Protein details for RBM45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH3-RBM45_HUMAN
    Recommended name:
    RNA-binding protein 45
    Protein Accession:
    Q8IUH3
    Secondary Accessions:
    • Q6NYL0
    • Q8NFC9

    Protein attributes for RBM45 Gene

    Size:
    476 amino acids
    Molecular mass:
    53502 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RBM45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM45 Gene

Proteomics data for RBM45 Gene at MOPED

Post-translational modifications for RBM45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM45 Gene

Antibody Products

No data available for DME Specific Peptides for RBM45 Gene

Domains & Families for RBM45 Gene

Gene Families for RBM45 Gene

Protein Domains for RBM45 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RBM45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUH3

UniProtKB/Swiss-Prot:

RBM45_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBM45: view

Function for RBM45 Gene

Molecular function for RBM45 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

Gene Ontology (GO) - Molecular Function for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 12220514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM45: view
genes like me logo Genes that share phenotypes with RBM45: view

Animal Model Products

CRISPR Products

miRNA for RBM45 Gene

miRTarBase miRNAs that target RBM45

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM45 Gene

Localization for RBM45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM45 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM45 Gene COMPARTMENTS Subcellular localization image for RBM45 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for RBM45 Gene

Pathways & Interactions for RBM45 Gene

SuperPathways for RBM45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM45 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM45 Gene

Drugs & Compounds for RBM45 Gene

No Compound Related Data Available

Transcripts for RBM45 Gene

Unigene Clusters for RBM45 Gene

RNA binding motif protein 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: -

Relevant External Links for RBM45 Gene

GeneLoc Exon Structure for
RBM45
ECgene alternative splicing isoforms for
RBM45

Expression for RBM45 Gene

mRNA expression in normal human tissues for RBM45 Gene

Protein differential expression in normal tissues from HIPED for RBM45 Gene

This gene is overexpressed in Plasma (38.9) and Adrenal (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM45 Gene



SOURCE GeneReport for Unigene cluster for RBM45 Gene Hs.377257

genes like me logo Genes that share expression patterns with RBM45: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RBM45 Gene

Orthologs for RBM45 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM45 36
  • 100 (a)
OneToOne
RBM45 35
  • 99.86 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RBM45 35
  • 93.46 (n)
  • 95.99 (a)
RBM45 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM45 36
  • 96 (a)
OneToOne
RBM45 35
  • 93.67 (n)
  • 97.47 (a)
mouse
(Mus musculus)
Mammalia Rbm45 16
Rbm45 36
  • 90 (a)
OneToOne
Rbm45 35
  • 86.36 (n)
  • 90.51 (a)
oppossum
(Monodelphis domestica)
Mammalia RBM45 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM45 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm45 35
  • 85.86 (n)
  • 91.56 (a)
chicken
(Gallus gallus)
Aves RBM45 35
  • 74.79 (n)
  • 71.58 (a)
RBM45 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia drbp1-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm45 35
  • 68.34 (n)
  • 70.52 (a)
Str.2753 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1796 35
zebrafish
(Danio rerio)
Actinopterygii rbm45 35
  • 62.97 (n)
  • 64.3 (a)
rbm45 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005505 35
  • 44.52 (n)
  • 40.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1316 36
  • 37 (a)
OneToOne
CG1316 35
  • 49.57 (n)
  • 40.71 (a)
Species with no ortholog for RBM45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBM45 Gene

ENSEMBL:
Gene Tree for RBM45 (if available)
TreeFam:
Gene Tree for RBM45 (if available)

Paralogs for RBM45 Gene

No data available for Paralogs for RBM45 Gene

Variants for RBM45 Gene

Sequence variations from dbSNP and Humsavar for RBM45 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs15515 -- 178,129,481(-) AAAAA(A/G)AAGCT utr-variant-3-prime
rs334056 -- 178,129,821(+) gtaat(C/T)gacaa downstream-variant-500B
rs2366366 -- 178,128,486(-) CATTA(C/T)ACTTT intron-variant
rs2163647 -- 178,128,835(+) TTGGT(A/G)TATTA intron-variant
rs3067447 -- 178,127,994(-) aaaaa(-/A/AA)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM45 Gene

Variant ID Type Subtype PubMed ID
nsv518790 CNV Gain 19592680
nsv875452 CNV Gain 21882294

Variation tolerance for RBM45 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM45 Gene

HapMap Linkage Disequilibrium report
RBM45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM45 Gene

Disorders for RBM45 Gene

Relevant External Links for RBM45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM45

No disorders were found for RBM45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM45 Gene

Publications for RBM45 Gene

  1. cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. (PMID: 12220514) Tamada H. … Endo H. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. (PMID: 25939382) Bakkar N. … Bowser R. (Mol. Cell. Biol. 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. (PMID: 24825905) Hans F. … Kahle P.J. (J. Biol. Chem. 2014) 3

Products for RBM45 Gene

Sources for RBM45 Gene

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