RBM45 Gene
protein-coding GIFtS: 46
GCID: GC02P178977
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RNA binding motif protein 45
| |
Aliases
for RBM45 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein 451 2 | | FLJ446121 | | DRB11 2 3 | | Developmentally Regulated RNA-Binding Protein 12 | | Developmentally-Regulated RNA-Binding Protein 12 3 | | Putative RNA Binding Protein RB-12 | | RB-12 3 | | RNA-Binding Protein 452 | | RNA-Binding Motif Protein 452 3 | | DRBP13 |
Export aliases for RBM45 gene to outside databasesPrevious GC identifers: GC02P178686 GC02P170847 |
Summaries
for RBM45 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RBM45_HUMAN, Q8IUH3Function: RNA-binding protein with binding specificity for poly(C). May play an important role in neural development
|
Genomic Views
for RBM45 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBM45 gene promoter:
FOXF2 Pax-2 Pax-2a C/EBPalpha PPAR-gamma1 HOXA5 Sox9 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBM45
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM45 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.2 Ensembl cytogenetic band: 2q31.2 HGNC cytogenetic band: 2q31.2RBM45 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P178977: view genomic region
(about GC identifiers)
Start:
|
178,977,151 bp from pter |
End:
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179,001,531 bp from pter |
Size:
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24,381 bases |
Orientation:
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plus strand |
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Proteins
for RBM45 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBM45_HUMAN, Q8IUH3 (See
protein sequence)Recommended Name: RNA-binding protein 45 Size: 476 amino acids; 53502 Da
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus
Secondary accessions: Q6NYL0 Q8NFC9Alternative splicing: 3 isoforms: Q8IUH3-1 Q8IUH3-2 Q8IUH3-3 (May be due to an intron retention)Explore the universe of human proteins at neXtProt for RBM45: NX_Q8IUH3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUH3
RBM45 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_694453.2
ENSEMBL proteins: ENSP00000286070 ENSP00000415940 ENSP00000389134
Human Recombinant Protein Products for RBM45:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RBM45 for ontologies About GeneDecksing
RBM45 Antibody Products:
Assay Products for RBM45: |
Protein
Domains /
Families
for RBM45 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM45 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IUH3ProtoNet protein and cluster: Q8IUH3 UniProtKB/Swiss-Prot: RBM45_HUMAN, Q8IUH3Similarity: Contains 3 RRM (RNA recognition motif) domains |
Function
for RBM45 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RBM45_HUMAN, Q8IUH3Function: RNA-binding protein with binding specificity for poly(C). May play an important role in neural development Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RBM45 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for RBM45:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM45 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RBM45 (NM_152945) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM45 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM45 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM45 |
|
Pathways & Interactions
for RBM45 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM45
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/742 Interacting proteins for RBM45 (Q8IUH32, 3 ENSP000002860704) via UniProtKB, MINT, STRING, and/or I2D (see all 742)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007399 | nervous system development |
ISS | -- | | GO:0030154 | cell differentiation |
IEA | -- |
RBM45 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBM45 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM45
Search CenterWatch for drugs/clinical trials and news about RBM45
|
Transcripts
for RBM45 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM45 gene: NM_152945.2 Unigene Cluster for RBM45: RNA binding motif protein 45 Hs.377257 [show with all ESTs]Unigene Representative Sequence: AF5265336 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000424000 ENST00000286070(uc002ulv.3) ENST00000493048 ENST00000455903
ENST00000424099 ENST00000464647
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM45 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM45 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBM45 (NM_152945) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM45 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM45 |
Additional cDNA sequence: AB036991.1 AF526533.1 AK126575.1 BC066549.1 6 DOTS entries: DT.109571 DT.100033637 DT.95348199 DT.100660198 DT.439356 DT.75196212 24/84 AceView cDNA sequences (see all 84): BE855816 AA767623 BE732027 AI376199 N39733 CB250468 AF526533 AV660729 CB321931 BX282352 CR624151 BE466172 BC066549 AW952412 AI471723 BM692945 AA443394 Z41207 BI827472 NM_152945 BE220640 AL535373 AW952421 BM668266
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for RBM45 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for RBM45
|
Expression
for RBM45 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTTTGAA
About this image
See RBM45 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM45
SOURCE GeneReport for Unigene cluster: Hs.377257
SABiosciences Custom PCR Arrays for RBM45
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM45
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBM45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM45 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM45 |
Orthologs
for RBM45 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RBM45 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for RBM45 (if available)
TreeFam Gene Tree for RBM45 (if available) |
Paralogs
for RBM45 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RBM45 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBM45 (178977151 - 179001531 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RBM45
1 Indel: 90144 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM45 |
|
Disorders
/ Diseases
for RBM45 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RBM45 for disorders About MalaCards
RBM45 for disorders About GeneDecksing
OMIM gene information: 608888
OMIM disorders: --
Export disorders for RBM45 gene to outside databases
|
Publications
for RBM45 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM45 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RBM45) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. (PubMed id 12220514)1, 2, 3, 9 Tamada H.... Endo H. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RBM45 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBM45 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM45 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBM45 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBM45 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBM45 gene:
Search GeneIP for patents involving RBM45
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM45 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM45 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM45 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBM45 | | OriGene 3'-UTR Clone for RBM45 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM45 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM45 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | RBM45 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM45 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM45 |
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