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Aliases for RBM45 Gene

Aliases for RBM45 Gene

  • RNA Binding Motif Protein 45 2 3 5
  • DRB1 3 4
  • RB-1 3 4
  • Developmentally Regulated RNA Binding Protein 1 2
  • Developmentally Regulated RNA-Binding Protein 1 3
  • Developmentally-Regulated RNA-Binding Protein 1 4
  • Putative RNA Binding Protein RB-1 3
  • RNA-Binding Motif Protein 45 4
  • RNA-Binding Protein 45 3
  • DRBP1 4

External Ids for RBM45 Gene

Previous GeneCards Identifiers for RBM45 Gene

  • GC02P178686
  • GC02P178977
  • GC02P170847

Summaries for RBM45 Gene

Entrez Gene Summary for RBM45 Gene

  • This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

GeneCards Summary for RBM45 Gene

RBM45 (RNA Binding Motif Protein 45) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for RBM45 Gene

  • RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM45 Gene

Genomics for RBM45 Gene

Regulatory Elements for RBM45 Gene

Enhancers for RBM45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G178111 1.2 ENCODE 4.5 +0.4 382 2.0 PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RBM45 GC02M178126
GH02G177997 0.5 ENCODE 3.9 -114.1 -114136 1.8 JUND IKZF1 SIN3A FOS IKZF2 PDE11A OSBPL6 RBM45 API5P2 GC02M177991
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM45 on UCSC Golden Path with GeneCards custom track

Promoters for RBM45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000126935 483 1401 PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for RBM45 Gene

Chromosome:
2
Start:
178,112,417 bp from pter
End:
178,139,011 bp from pter
Size:
26,595 bases
Orientation:
Plus strand

Genomic View for RBM45 Gene

Genes around RBM45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM45 Gene

Proteins for RBM45 Gene

  • Protein details for RBM45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH3-RBM45_HUMAN
    Recommended name:
    RNA-binding protein 45
    Protein Accession:
    Q8IUH3
    Secondary Accessions:
    • Q6NYL0
    • Q8NFC9

    Protein attributes for RBM45 Gene

    Size:
    476 amino acids
    Molecular mass:
    53502 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RBM45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM45 Gene

Post-translational modifications for RBM45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM45 Gene

No data available for DME Specific Peptides for RBM45 Gene

Domains & Families for RBM45 Gene

Gene Families for RBM45 Gene

Suggested Antigen Peptide Sequences for RBM45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM45: view

No data available for UniProtKB/Swiss-Prot for RBM45 Gene

Function for RBM45 Gene

Molecular function for RBM45 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

Gene Ontology (GO) - Molecular Function for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 12220514
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBM45: view
genes like me logo Genes that share phenotypes with RBM45: view

Animal Model Products

miRNA for RBM45 Gene

miRTarBase miRNAs that target RBM45

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RBM45

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM45 Gene

Localization for RBM45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM45 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM45 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12220514
GO:0005737 cytoplasm IEA,IDA 12220514
genes like me logo Genes that share ontologies with RBM45: view

Pathways & Interactions for RBM45 Gene

SuperPathways for RBM45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RBM45: view

No data available for Pathways by source and SIGNOR curated interactions for RBM45 Gene

Drugs & Compounds for RBM45 Gene

No Compound Related Data Available

Transcripts for RBM45 Gene

Unigene Clusters for RBM45 Gene

RNA binding motif protein 45:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RBM45

Alternative Splicing Database (ASD) splice patterns (SP) for RBM45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: -

Relevant External Links for RBM45 Gene

GeneLoc Exon Structure for
RBM45
ECgene alternative splicing isoforms for
RBM45

Expression for RBM45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM45 Gene

Protein differential expression in normal tissues from HIPED for RBM45 Gene

This gene is overexpressed in Plasma (38.9) and Adrenal (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM45 Gene



NURSA nuclear receptor signaling pathways regulating expression of RBM45 Gene:

RBM45

SOURCE GeneReport for Unigene cluster for RBM45 Gene:

Hs.377257
genes like me logo Genes that share expression patterns with RBM45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM45 Gene

Orthologs for RBM45 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM45 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia RBM45 34 35
  • 93.67 (n)
cow
(Bos Taurus)
Mammalia RBM45 34 35
  • 93.46 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM45 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm45 34 16 35
  • 86.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RBM45 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm45 34
  • 85.86 (n)
chicken
(Gallus gallus)
Aves RBM45 34 35
  • 74.79 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm45 34
  • 68.34 (n)
Str.2753 34
African clawed frog
(Xenopus laevis)
Amphibia drbp1-pending-prov 34
zebrafish
(Danio rerio)
Actinopterygii rbm45 34 35
  • 62.97 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1796 34
fruit fly
(Drosophila melanogaster)
Insecta CG1316 34 35
  • 49.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005505 34
  • 44.52 (n)
Species where no ortholog for RBM45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBM45 Gene

ENSEMBL:
Gene Tree for RBM45 (if available)
TreeFam:
Gene Tree for RBM45 (if available)

Paralogs for RBM45 Gene

Pseudogenes.org Pseudogenes for RBM45 Gene

genes like me logo Genes that share paralogs with RBM45: view

No data available for Paralogs for RBM45 Gene

Variants for RBM45 Gene

Sequence variations from dbSNP and Humsavar for RBM45 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000027279 -- 178,125,082(+) CTGCA(C/G)AAAAT intron-variant
rs1000119321 -- 178,130,014(+) CAAAA(A/T)GTGTT downstream-variant-500B
rs1000282348 -- 178,117,749(+) TTTCA(A/G)TCTAG intron-variant
rs1000389593 -- 178,111,169(+) TCCAC(C/T)CTCAC upstream-variant-2KB
rs1000438015 -- 178,116,945(+) GGAAT(C/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM45 Gene

Variant ID Type Subtype PubMed ID
nsv518790 CNV gain 19592680
nsv583739 CNV loss 21841781

Variation tolerance for RBM45 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM45 Gene

Disorders for RBM45 Gene

Relevant External Links for RBM45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM45

No disorders were found for RBM45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM45 Gene

Publications for RBM45 Gene

  1. cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. (PMID: 12220514) Tamada H. … Endo H. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Developmentally Regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates. (PMID: 27226551) Mashiko T. … Endo H. (J. Biol. Chem. 2016) 3 64
  4. RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. (PMID: 25939382) Bakkar N. … Bowser R. (Mol. Cell. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RBM45 Gene

  • Addgene plasmids for RBM45

Sources for RBM45 Gene

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