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Aliases for RBM42 Gene

Aliases for RBM42 Gene

  • RNA Binding Motif Protein 42 2 3
  • RNA-Binding Motif Protein 42 4

External Ids for RBM42 Gene

Previous GeneCards Identifiers for RBM42 Gene

  • GC19P040812
  • GC19P036119
  • GC19P032625

Summaries for RBM42 Gene

GeneCards Summary for RBM42 Gene

RBM42 (RNA Binding Motif Protein 42) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TIAL1.

UniProtKB/Swiss-Prot for RBM42 Gene

  • Binds (via the RRM domain) to the 3-untranslated region (UTR) of CDKN1A mRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM42 Gene

Genomics for RBM42 Gene

Regulatory Elements for RBM42 Gene

Genomic Location for RBM42 Gene

Start:
35,629,030 bp from pter
End:
35,637,686 bp from pter
Size:
8,657 bases
Orientation:
Plus strand

Genomic View for RBM42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM42 Gene

Proteins for RBM42 Gene

  • Protein details for RBM42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTD8-RBM42_HUMAN
    Recommended name:
    RNA-binding protein 42
    Protein Accession:
    Q9BTD8
    Secondary Accessions:
    • O00320
    • Q8N5R7
    • Q9BU66

    Protein attributes for RBM42 Gene

    Size:
    480 amino acids
    Molecular mass:
    50414 Da
    Quaternary structure:
    • Interacts with HNRNPK.
    SequenceCaution:
    • Sequence=AAB57629.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM42 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM42 Gene

Proteomics data for RBM42 Gene at MOPED

Post-translational modifications for RBM42 Gene

  • Ubiquitination at Lys430
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM42 Gene

No data available for DME Specific Peptides for RBM42 Gene

Domains for RBM42 Gene

Gene Families for RBM42 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBM42 Gene

Suggested Antigen Peptide Sequences for RBM42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTD8

UniProtKB/Swiss-Prot:

RBM42_HUMAN :
  • Q9BTD8
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM RBM42 family.
genes like me logo Genes that share domains with RBM42: view

Function for RBM42 Gene

Molecular function for RBM42 Gene

UniProtKB/Swiss-Prot Function: Binds (via the RRM domain) to the 3-untranslated region (UTR) of CDKN1A mRNA.

Gene Ontology (GO) - Molecular Function for RBM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM42: view
genes like me logo Genes that share phenotypes with RBM42: view

Animal Model Products

CRISPR Products

miRNA for RBM42 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM42

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM42 Gene

Localization for RBM42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM42 Gene

Nucleus. Cytoplasm. Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM42 Gene COMPARTMENTS Subcellular localization image for RBM42 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RBM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RBM42: view

Pathways for RBM42 Gene

SuperPathways for RBM42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048025 negative regulation of mRNA splicing, via spliceosome IEA --
genes like me logo Genes that share ontologies with RBM42: view

No data available for Pathways by source for RBM42 Gene

Transcripts for RBM42 Gene

Unigene Clusters for RBM42 Gene

RNA binding motif protein 42:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM42

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for RBM42 Gene

GeneLoc Exon Structure for
RBM42
ECgene alternative splicing isoforms for
RBM42

Expression for RBM42 Gene

mRNA expression in normal human tissues for RBM42 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM42 Gene

SOURCE GeneReport for Unigene cluster for RBM42 Gene Hs.5086

genes like me logo Genes that share expressions with RBM42: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM42 Gene

Orthologs for RBM42 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM42 35
  • 99.86 (n)
  • 100 (a)
RBM42 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM42 35
  • 91.59 (n)
  • 99.11 (a)
RBM42 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM42 35
  • 92.14 (n)
  • 98.95 (a)
mouse
(Mus musculus)
Mammalia Rbm42 35
  • 89.73 (n)
  • 98.31 (a)
Rbm42 16
Rbm42 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM42 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM42 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm42 35
  • 89.66 (n)
  • 98.52 (a)
lizard
(Anolis carolinensis)
Reptilia RBM42 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6145 35
zebrafish
(Danio rerio)
Actinopterygii rbm42 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2931 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-262 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 36
  • 13 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3110 35
soybean
(Glycine max)
eudicotyledons Gma.2093 35
barley
(Hordeum vulgare)
Liliopsida Hv.4404 35
corn
(Zea mays)
Liliopsida Zm.15567 35
rice
(Oryza sativa)
Liliopsida Os.35508 35
wheat
(Triticum aestivum)
Liliopsida Ta.4695 35
Species with no ortholog for RBM42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RBM42 Gene

ENSEMBL:
Gene Tree for RBM42 (if available)
TreeFam:
Gene Tree for RBM42 (if available)

Paralogs for RBM42 Gene

Paralogs for RBM42 Gene

Selected SIMAP similar genes for RBM42 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RBM42: view

Variants for RBM42 Gene

Sequence variations from dbSNP and Humsavar for RBM42 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs732378 -- 35,631,984(+) ATTTT(C/T)TACAT intron-variant
rs756784 -- 35,632,589(+) ATCCC(A/G)CTGCC intron-variant
rs1139627 -- 35,634,005(+) CAGGC(C/T)TCATG reference, missense
rs1858844 -- 35,638,086(+) GCACC(A/G)TTAGA downstream-variant-500B
rs2239914 -- 35,632,501(+) CCCCT(C/T)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM42 Gene

Variant ID Type Subtype PubMed ID
nsv911629 CNV Loss 21882294

Relevant External Links for RBM42 Gene

HapMap Linkage Disequilibrium report
RBM42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM42 Gene

Disorders for RBM42 Gene

No disorders were found for RBM42 Gene.

No data available for UniProtKB/Swiss-Prot for RBM42 Gene

Publications for RBM42 Gene

  1. hnRNP K interacts with RNA binding motif protein 42 and functions in the maintenance of cellular ATP level during stress conditions. (PMID: 19170760) Fukuda T. … Irie K. (Genes Cells 2009) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for RBM42 Gene

Sources for RBM42 Gene

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