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Aliases for RBM42 Gene

Aliases for RBM42 Gene

  • RNA Binding Motif Protein 42 2 3 5
  • RNA-Binding Motif Protein 42 4

External Ids for RBM42 Gene

Previous GeneCards Identifiers for RBM42 Gene

  • GC19P040812
  • GC19P036119
  • GC19P032625
  • GC19P035694
  • GC19P035817

Summaries for RBM42 Gene

GeneCards Summary for RBM42 Gene

RBM42 (RNA Binding Motif Protein 42) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TIAL1.

UniProtKB/Swiss-Prot for RBM42 Gene

  • Binds (via the RRM domain) to the 3-untranslated region (UTR) of CDKN1A mRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM42 Gene

Genomics for RBM42 Gene

Regulatory Elements for RBM42 Gene

Promoters for RBM42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM42 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM42 Gene

Chromosome:
19
Start:
35,629,030 bp from pter
End:
35,637,686 bp from pter
Size:
8,657 bases
Orientation:
Plus strand

Genomic View for RBM42 Gene

Genes around RBM42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM42 Gene

Proteins for RBM42 Gene

  • Protein details for RBM42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTD8-RBM42_HUMAN
    Recommended name:
    RNA-binding protein 42
    Protein Accession:
    Q9BTD8
    Secondary Accessions:
    • O00320
    • Q8N5R7
    • Q9BU66

    Protein attributes for RBM42 Gene

    Size:
    480 amino acids
    Molecular mass:
    50414 Da
    Quaternary structure:
    • Interacts with HNRNPK.
    SequenceCaution:
    • Sequence=AAB57629.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM42 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM42 Gene

Proteomics data for RBM42 Gene at MOPED

Post-translational modifications for RBM42 Gene

  • Ubiquitination at Lys 430
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM42 Gene

Antibody Products

No data available for DME Specific Peptides for RBM42 Gene

Domains & Families for RBM42 Gene

Gene Families for RBM42 Gene

Protein Domains for RBM42 Gene

Suggested Antigen Peptide Sequences for RBM42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTD8

UniProtKB/Swiss-Prot:

RBM42_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM RBM42 family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM RBM42 family.
genes like me logo Genes that share domains with RBM42: view

Function for RBM42 Gene

Molecular function for RBM42 Gene

UniProtKB/Swiss-Prot Function:
Binds (via the RRM domain) to the 3-untranslated region (UTR) of CDKN1A mRNA.

Gene Ontology (GO) - Molecular Function for RBM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RBM42: view
genes like me logo Genes that share phenotypes with RBM42: view

Animal Model Products

CRISPR Products

miRNA for RBM42 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM42 Gene

Localization for RBM42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM42 Gene

Nucleus. Cytoplasm. Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM42 Gene COMPARTMENTS Subcellular localization image for RBM42 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for RBM42 Gene

Pathways & Interactions for RBM42 Gene

SuperPathways for RBM42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM42 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM42 Gene

Drugs & Compounds for RBM42 Gene

No Compound Related Data Available

Transcripts for RBM42 Gene

Unigene Clusters for RBM42 Gene

RNA binding motif protein 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for RBM42 Gene

GeneLoc Exon Structure for
RBM42
ECgene alternative splicing isoforms for
RBM42

Expression for RBM42 Gene

mRNA expression in normal human tissues for RBM42 Gene

Protein differential expression in normal tissues from HIPED for RBM42 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.1) and Lung (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM42 Gene



SOURCE GeneReport for Unigene cluster for RBM42 Gene Hs.5086

genes like me logo Genes that share expression patterns with RBM42: view

Protein tissue co-expression partners for RBM42 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM42 Gene

Orthologs for RBM42 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM42 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBM42 35
  • 91.59 (n)
  • 99.11 (a)
RBM42 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM42 35
  • 92.14 (n)
  • 98.95 (a)
mouse
(Mus musculus)
Mammalia Rbm42 35
  • 89.73 (n)
  • 98.31 (a)
Rbm42 16
Rbm42 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBM42 35
  • 99.86 (n)
  • 100 (a)
RBM42 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm42 35
  • 89.66 (n)
  • 98.52 (a)
oppossum
(Monodelphis domestica)
Mammalia RBM42 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM42 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM42 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6145 35
zebrafish
(Danio rerio)
Actinopterygii rbm42 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2931 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-262 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 36
  • 13 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.2093 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3110 35
barley
(Hordeum vulgare)
Liliopsida Hv.4404 35
rice
(Oryza sativa)
Liliopsida Os.35508 35
wheat
(Triticum aestivum)
Liliopsida Ta.4695 35
corn
(Zea mays)
Liliopsida Zm.15567 35
Species with no ortholog for RBM42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RBM42 Gene

ENSEMBL:
Gene Tree for RBM42 (if available)
TreeFam:
Gene Tree for RBM42 (if available)

Paralogs for RBM42 Gene

Paralogs for RBM42 Gene

(3) SIMAP similar genes for RBM42 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RBM42: view

Variants for RBM42 Gene

Sequence variations from dbSNP and Humsavar for RBM42 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs732378 -- 35,631,984(+) ATTTT(C/T)TACAT intron-variant
rs756784 -- 35,632,589(+) ATCCC(A/G)CTGCC intron-variant
rs1858844 -- 35,638,086(+) GCACC(A/G)TTAGA downstream-variant-500B
rs1139627 -- 35,634,005(+) CAGGC(C/T)TCATG reference, missense
rs2285415 -- 35,631,539(+) AGCAC(A/G)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM42 Gene

Variant ID Type Subtype PubMed ID
nsv911629 CNV Loss 21882294

Variation tolerance for RBM42 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM42 Gene

HapMap Linkage Disequilibrium report
RBM42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM42 Gene

Disorders for RBM42 Gene

Relevant External Links for RBM42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM42

No disorders were found for RBM42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM42 Gene

Publications for RBM42 Gene

  1. hnRNP K interacts with RNA binding motif protein 42 and functions in the maintenance of cellular ATP level during stress conditions. (PMID: 19170760) Fukuda T. … Irie K. (Genes Cells 2009) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RBM42 Gene

Sources for RBM42 Gene

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