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RBM38 Gene

protein-coding   GIFtS: 50
GCID: GC20P055966

RNA Binding Motif Protein 38

(Previous names: RNA-binding region (RNP1, RRM) containing 1)
(Previous symbol: RNPC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Motif Protein 381 2     SEB4B2
RNPC11 2 3 5     SEB4D2
RNA-Binding Region (RNP1, RRM) Containing 11 2     dJ800J21.22
HSRNASEB2 3     RNA-Binding Protein 382
CLL-Associated Antigen KW-52 3     SEB43
RNA-Binding Region-Containing Protein 12 3     RNA-Binding Motif Protein 383
SsDNA-Binding Protein SEB42 3     

External Ids:    HGNC: 158181   Entrez Gene: 555442   Ensembl: ENSG000001328197   OMIM: 6124285   UniProtKB: Q9H0Z93   

Export aliases for RBM38 gene to outside databases

Previous GC identifers: GC20P055400 GC20P052749


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RBM38 Gene:
RBM38 (RNA binding motif protein 38) is a protein-coding gene. Diseases associated with RBM38 include chronic lymphocytic leukemia, and esophagitis. GO annotations related to this gene include mRNA 3'-UTR binding and nucleotide binding. An important paralog of this gene is RBM24.

UniProtKB/Swiss-Prot: RBM38_HUMAN, Q9H0Z9
Function: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the
stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A
is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle
arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the
stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates
the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic
differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM38 gene promoter:
         Sox5   AML1a   CUTL1   RelA   NF-kappaB   C/EBPalpha   c-Ets-1   PPAR-gamma2   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM38 promoter sequence
   Search Chromatin IP Primers for RBM38

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.31

RBM38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM38 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P055966:  view genomic region     (about GC identifiers)

Start:
55,966,454 bp from pter      End:
55,984,389 bp from pter
Size:
17,936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RBM38_HUMAN, Q9H0Z9 (See protein sequence)
Recommended Name: RNA-binding protein 38  
Size: 239 amino acids; 25498 Da
Caution: It is uncertain whether Met-1 or Met-24 is the initiator
Sequence caution: Sequence=AAH18711.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAL99924.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA53064.1;
Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=EAW75522.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for RBM38:
2CQD (3D)    
Secondary accessions: A6NDK1 A6NMU6 Q15350 Q15351 Q9BYK3 Q9BYK4
Alternative splicing: 2 isoforms:  Q9H0Z9-1   Q9H0Z9-2   

Explore the universe of human proteins at neXtProt for RBM38: NX_Q9H0Z9

Explore proteomics data for RBM38 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBM38 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_059965.2  NP_906270.1  

    ENSEMBL proteins: 
     ENSP00000348538   ENSP00000407848   ENSP00000343718   ENSP00000345248   ENSP00000360263  

    RBM38 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9H0Z9

    ProtoNet protein and cluster: Q9H0Z9

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM38_HUMAN, Q9H0Z9
    Similarity: Belongs to the RBM38 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    RBM38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM38_HUMAN, Q9H0Z9
    Function: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the
    stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A
    is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle
    arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the
    stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates
    the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic
    differentiation
    Induction: By p53/TP53 family. Directly induced by p53/TP53, TP63/p63 and TP73/p73

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003729mRNA binding IEA--
    GO:0003730mRNA 3'-UTR binding IDA17050675
    GO:0044822poly(A) RNA binding IDA--
         
    RBM38 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RBM38:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBM38
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBM38
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    miRNA
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    miRTarBase miRNAs that target RBM38:
    hsa-mir-320a (MIRT044628)

    Block miRNA regulation of human, mouse, rat RBM38 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM38 (see all 28):
    hsa-miR-125a-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3133 hsa-miR-570 hsa-let-7g hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidRBM38 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RBM38

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM38

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM38


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBM38_HUMAN, Q9H0Z9: Cytoplasm, cytosol. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005829cytosol IEA--

    RBM38 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM38
    Interactions:

        Search GeneGlobe Interaction Network for RBM38

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for RBM38 (Q9H0Z93 ENSP000003485384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOLLIPQ9H0E23I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    RCHY1ENSP000003212394STRING: ENSP00000321239
    RNF44ENSP000002748114STRING: ENSP00000274811
    QKIENSP000003549514STRING: ENSP00000354951
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA17050675
    GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA17050675
    GO:0007049cell cycle IEA--
    GO:0007050NOT cell cycle arrest IDA17050675

    RBM38 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM38



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RBM38 gene (2 alternative transcripts): 
    NM_017495.5  NM_183425.2  

    Unigene Cluster for RBM38:

    RNA binding motif protein 38
    Hs.236361  [show with all ESTs]
    Unigene Representative Sequence: CR627021
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356208(uc010zzj.2 uc010zzk.2) ENST00000440234 ENST00000342690
    ENST00000344785 ENST00000371219
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RBM38 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM38 (see all 28):
    hsa-miR-125a-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3133 hsa-miR-570 hsa-let-7g hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidRBM38 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RBM38
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    GenScript: all cDNA clones in your preferred vector (see all 2): RBM38 (NM_017495)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM38
    Primer
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    OriGene qPCR primer pairs and template standards for RBM38
    OriGene qSTAR qPCR primer pairs in human, mouse for RBM38
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM38
      QuantiTect SYBR Green Assays in human, mouse, rat RBM38
      QuantiFast Probe-based Assays in human, mouse, rat RBM38

    Additional mRNA sequence: 

    AF432218.1 BC018711.1 CR627021.1 X75314.1 

    10 DOTS entries:

    DT.447907  DT.97861325  DT.91754643  DT.99963012  DT.100757538  DT.100781575  DT.95361490  DT.95294244 
    DT.102821143  DT.91754627 

    Selected AceView cDNA sequences (see all 405):

    BI792857 BE646129 CB528600 BI793042 BI793122 AW341002 BQ773451 BC018711 
    AI201337 BE673854 BG757164 AI313258 BU149193 AI871821 BE327055 BF445364 
    BQ677177 AA355085 BE409382 AI564447 CB242018 AI440356 BF064184 R89184 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RBM38    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for RBM38

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBM38 expression in normal human tissues (normalized intensities)      RBM38 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTGAGAGG
    RBM38 Expression
    About this image


    RBM38 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Lymph (Hematopoietic System)
    RBM38 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM38 Protein Expression

    Genevestigator expression for RBM38

    SOURCE GeneReport for Unigene cluster: Hs.236361
        Custom PCR Arrays for RBM38
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBM38 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm381 , 5 RNA binding motif protein 381, 5 89.17(n)1
    95.36(a)1
      2 (95.67 cM)5
    561901  NM_019547.21  NP_062420.21 
     1730204985 
    chicken
    (Gallus gallus)
    Aves RBM386
    RNA-binding protein 38
    74(a)
    1 ↔ 1
    20(11959016-11971950)
    lizard
    (Anolis carolinensis)
    Reptilia RBM386
    RNA binding motif protein 38
    72(a)
    1 ↔ 1
    GL343217.1(1133163-1167833)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986032 RRM-type RNA-binding protein XSEB4R 77.73(n)    AY289193.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnpc12 RNA-binding region (RNP1, RRM) containing 1 79.49(n)   333991  AB097829.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sup-126
    Protein SUP-12, isoform b (sup-12) mRNA, complete ...
    42(a)
    1 → many
    X(3904591-3907673) WBGene00006321
    rice
    (Oryza sativa)
    Liliopsida Os.151142 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.56(n)    AK067428.1 


    ENSEMBL Gene Tree for RBM38 (if available)
    TreeFam Gene Tree for RBM38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBM38 gene
    RBM242  
    Selected SIMAP similar genes for RBM38 using alignment to 4 protein entries:     RBM38_HUMAN (see all proteins) (see all similar genes):
    RNPC1    RBM24    HNRPA1    MSI2    CIRBP    DAZAP1
    RBMX    BOLL    DKFZp686A11192    DKFZp686C17209    DKFZp781C0423    DKFZp781I1140
    RBM39    HNRNPA1    RBM3    RBMXL3    D10S102    HNRNPA2B1

    RBM38 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBM38 (see all 429)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3284931,2
    C,A--55970139(+) AGTGCG/ACAGGC 2 -- int113Minor allele frequency- A:0.18NA WA CSA EA 375
    rs1847845421,2
    --55970164(+) CTCTGC/GCCTCC 2 -- int10--------
    rs1882967341,2
    --55970200(+) GCAGGC/TCTCTG 2 -- int10--------
    rs1921684731,2
    --55970208(+) CTGAGA/GATGGG 2 -- int10--------
    rs732918991,2
    C,F--55970283(+) GGCCTG/AGGGGC 2 -- int12Minor allele frequency- A:0.05WA 120
    rs24267141,2
    C,F,A,H--55970333(+) CGTCCA/GGGAGG 2 -- int119Minor allele frequency- G:0.46NS EA NA 2228
    rs1416477811,2
    --55970370(+) TGAACG/TCATGC 2 -- int10--------
    rs1850415641,2
    --55970392(+) GGGACA/GGTGGG 2 -- int10--------
    rs1895543731,2
    --55970462(+) AGAAGC/TAGTTG 2 -- int10--------
    rs1820973661,2
    --55970473(+) GGATCC/GGTCAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for RBM38 (55966454 - 55984389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RBM38:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722602CNV Deletion23290073
    esv2722601CNV Deletion23290073
    esv2722603CNV Deletion23290073
    nsv3424CNV Insertion18451855
    nsv912958CNV Loss21882294
    nsv517912CNV Loss19592680
    esv33591CNV Loss17666407
    nsv516617CNV Loss19592680
    dgv4582n71CNV Loss21882294
    esv33697CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612428    OMIM disorders: --

    4 diseases for RBM38:    About MalaCards
    chronic lymphocytic leukemia    esophagitis    adenocarcinoma    leukemia


    RBM38 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RBM38

    Export disorders for RBM38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBM38 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RBM38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    2. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1, 4 Barber M.J....Krauss R.M. (PLoS ONE 2010)
    3. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. (PubMed id 19285943)1, 2 Warzecha C.C.... Carstens R.P. (Mol. Cell 2009)
    4. RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. (PubMed id 17050675)1, 2 Shu L.... Chen X. (Genes Dev. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. (PubMed id 12200376)1, 2 Krackhardt A.M.... Gribben J.G. (Blood 2002)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability. (PubMed id 23836903)1 Yin T....Chen X. (J. Biol. Chem. 2013)
    9. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. (PubMed id 23300278)1 Saxena R....Sanghera D.K. (Diabetes 2013)
    10. Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1. (PubMed id 24142875)1 Zhang M....Chen X. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55544 HGNC: 15818 AceView: RNPC1 Ensembl:ENSG00000132819 euGenes: HUgn55544
    ECgene: RBM38 H-InvDB: RBM38

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBM38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBM38 gene:
    Search GeneIP for patents involving RBM38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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