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Aliases for RBM38 Gene

Aliases for RBM38 Gene

  • RNA Binding Motif Protein 38 2 3
  • RNA-Binding Region (RNP1, RRM) Containing 1 2 3
  • RNA-Binding Region-Containing Protein 1 3 4
  • CLL-Associated Antigen KW-5 3 4
  • SsDNA-Binding Protein SEB4 3 4
  • HSRNASEB 3 4
  • RNPC1 3 4
  • RNA-Binding Motif Protein 38 4
  • DJ800J21.2 3
  • SEB4B 3
  • SEB4D 3
  • SEB4 4

External Ids for RBM38 Gene

Previous HGNC Symbols for RBM38 Gene

  • RNPC1

Previous GeneCards Identifiers for RBM38 Gene

  • GC20P055400
  • GC20P055966
  • GC20P052749

Summaries for RBM38 Gene

GeneCards Summary for RBM38 Gene

RBM38 (RNA Binding Motif Protein 38) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM24.

UniProtKB/Swiss-Prot for RBM38 Gene

  • RNA-binding protein that specifically bind the 3-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM38 Gene

Genomics for RBM38 Gene

Regulatory Elements for RBM38 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBM38 Gene

Chromosome:
20
Start:
57,391,398 bp from pter
End:
57,409,333 bp from pter
Size:
17,936 bases
Orientation:
Plus strand

Genomic View for RBM38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM38 Gene

Proteins for RBM38 Gene

  • Protein details for RBM38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0Z9-RBM38_HUMAN
    Recommended name:
    RNA-binding protein 38
    Protein Accession:
    Q9H0Z9
    Secondary Accessions:
    • A6NDK1
    • A6NMU6
    • Q15350
    • Q15351
    • Q9BYK3
    • Q9BYK4

    Protein attributes for RBM38 Gene

    Size:
    239 amino acids
    Molecular mass:
    25498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH18711.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL99924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA53064.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=EAW75522.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM38 Gene

    Alternative splice isoforms for RBM38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM38 Gene

Proteomics data for RBM38 Gene at MOPED

Post-translational modifications for RBM38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM38 Gene

Antibody Products

No data available for DME Specific Peptides for RBM38 Gene

Domains & Families for RBM38 Gene

Gene Families for RBM38 Gene

Protein Domains for RBM38 Gene

Suggested Antigen Peptide Sequences for RBM38 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0Z9

UniProtKB/Swiss-Prot:

RBM38_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RBM38 family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RBM38 family.
genes like me logo Genes that share domains with RBM38: view

Function for RBM38 Gene

Molecular function for RBM38 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that specifically bind the 3-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
UniProtKB/Swiss-Prot Induction:
By p53/TP53 family. Directly induced by p53/TP53, TP63/p63 and TP73/p73.

Gene Ontology (GO) - Molecular Function for RBM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003729 mRNA binding IDA 17050675
GO:0003730 mRNA 3-UTR binding IDA 17050675
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM38: view
genes like me logo Genes that share phenotypes with RBM38: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM38

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM38 Gene

Localization for RBM38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM38 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM38 Gene COMPARTMENTS Subcellular localization image for RBM38 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RBM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17050675
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RBM38: view

Pathways & Interactions for RBM38 Gene

SuperPathways for RBM38 Gene

No Data Available

Interacting Proteins for RBM38 Gene

SIGNOR curated interactions for RBM38 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RBM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA 17050675
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA 17050675
GO:0007049 cell cycle IEA --
GO:0007050 NOT cell cycle arrest IDA 17050675
genes like me logo Genes that share ontologies with RBM38: view

No data available for Pathways by source for RBM38 Gene

Drugs & Compounds for RBM38 Gene

No Compound Related Data Available

Transcripts for RBM38 Gene

Unigene Clusters for RBM38 Gene

RNA binding motif protein 38:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM38

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM38 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RBM38 Gene

GeneLoc Exon Structure for
RBM38
ECgene alternative splicing isoforms for
RBM38

Expression for RBM38 Gene

mRNA expression in normal human tissues for RBM38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBM38 Gene

This gene is overexpressed in Whole Blood (x10.3) and Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for RBM38 Gene

This gene is overexpressed in Heart (35.2), Peripheral blood mononuclear cells (9.6), CD8 Tcells (8.6), and NK cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM38 Gene



SOURCE GeneReport for Unigene cluster for RBM38 Gene Hs.236361

genes like me logo Genes that share expression patterns with RBM38: view

Protein tissue co-expression partners for RBM38 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RBM38 Gene

Orthologs for RBM38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM38 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBM38 35
  • 92.47 (n)
  • 96.23 (a)
RBM38 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm38 35
  • 89.17 (n)
  • 95.36 (a)
Rbm38 16
Rbm38 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBM38 35
  • 98.61 (n)
  • 98.15 (a)
-- 36
  • 97 (a)
OneToMany
RBM38 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RBM38 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM38 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM38 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM38 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM38 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm38 35
  • 74.8 (n)
  • 78.4 (a)
Str.15196 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398603 35
zebrafish
(Danio rerio)
Actinopterygii rbm38 35
  • 68.95 (n)
  • 69.12 (a)
rnpc1 35
rbm38 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6474 35
worm
(Caenorhabditis elegans)
Secernentea sup-12 36
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.15114 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10652 36
  • 43 (a)
OneToMany
Species with no ortholog for RBM38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM38 Gene

ENSEMBL:
Gene Tree for RBM38 (if available)
TreeFam:
Gene Tree for RBM38 (if available)

Paralogs for RBM38 Gene

Paralogs for RBM38 Gene

genes like me logo Genes that share paralogs with RBM38: view

Variants for RBM38 Gene

Sequence variations from dbSNP and Humsavar for RBM38 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs11021 -- 57,409,036(-) CCCAA(A/G)ACAGG utr-variant-3-prime
rs186622 -- 57,403,103(+) TTCCT(A/G)GTTGT intron-variant
rs328492 -- 57,394,641(+) GGAAT(C/G)TGTTT intron-variant
rs328493 -- 57,395,083(+) AGTGC(A/G)CAGGC intron-variant
rs328494 -- 57,395,994(+) TTCCT(C/T)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM38 Gene

Variant ID Type Subtype PubMed ID
nsv3424 CNV Insertion 18451855
nsv516617 CNV Loss 19592680
nsv912958 CNV Loss 21882294
dgv4582n71 CNV Loss 21882294
esv33591 CNV Loss 17666407
esv2722601 CNV Deletion 23290073
esv2722602 CNV Deletion 23290073
esv2722603 CNV Deletion 23290073
esv33697 CNV Gain 17666407
nsv517912 CNV Loss 19592680

Variation tolerance for RBM38 Gene

Residual Variation Intolerance Score: 65.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM38 Gene

HapMap Linkage Disequilibrium report
RBM38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM38 Gene

Disorders for RBM38 Gene

Relevant External Links for RBM38

Genetic Association Database (GAD)
RBM38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM38
genes like me logo Genes that share disorders with RBM38: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM38 Gene

Publications for RBM38 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer. (PMID: 24884756) Xue J.Q. … Ding Q. (BMC Cancer 2014) 67
  3. Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells. (PMID: 24663081) Ding C. … Zheng S. (Int J Mol Sci 2014) 67
  4. RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability. (PMID: 23836903) Yin T. … Chen X. (J. Biol. Chem. 2013) 67
  5. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. (PMID: 23300278) Saxena R. … Sanghera D.K. (Diabetes 2013) 67

Products for RBM38 Gene

Sources for RBM38 Gene

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