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Aliases for RBM38 Gene

Aliases for RBM38 Gene

  • RNA Binding Motif Protein 38 2 3
  • RNPC1 3 4 6
  • RNA-Binding Region (RNP1, RRM) Containing 1 2 3
  • RNA-Binding Region-Containing Protein 1 3 4
  • CLL-Associated Antigen KW-5 3 4
  • SsDNA-Binding Protein SEB4 3 4
  • HSRNASEB 3 4
  • RNA-Binding Motif Protein 38 4
  • RNA-Binding Protein 38 3
  • DJ800J21.2 3
  • SEB4B 3
  • SEB4D 3
  • SEB4 4

External Ids for RBM38 Gene

Previous Symbols for RBM38 Gene

  • RNPC1

Summaries for RBM38 Gene

GeneCards Summary for RBM38 Gene

RBM38 (RNA Binding Motif Protein 38) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and mRNA 3-UTR binding. An important paralog of this gene is RBM24.

UniProtKB/Swiss-Prot for RBM38 Gene

  • RNA-binding protein that specifically bind the 3-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM38 Gene

Genomics for RBM38 Gene

Genomic Location for RBM38 Gene

Start:
57,391,398 bp from pter
End:
57,409,333 bp from pter
Size:
17,936 bases
Orientation:
Plus strand

Genomic View for RBM38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM38 Gene

Regulatory Elements for RBM38 Gene

Proteins for RBM38 Gene

  • Protein details for RBM38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0Z9-RBM38_HUMAN
    Recommended name:
    RNA-binding protein 38
    Protein Accession:
    Q9H0Z9
    Secondary Accessions:
    • A6NDK1
    • A6NMU6
    • Q15350
    • Q15351
    • Q9BYK3
    • Q9BYK4

    Protein attributes for RBM38 Gene

    Size:
    239 amino acids
    Molecular mass:
    25498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH18711.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL99924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA53064.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=EAW75522.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM38 Gene

    Alternative splice isoforms for RBM38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM38 Gene

Proteomics data for RBM38 Gene at MOPED

Post-translational modifications for RBM38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM38 Gene

No data available for DME Specific Peptides for RBM38 Gene

Domains for RBM38 Gene

Gene Families for RBM38 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBM38 Gene

UniProtKB/Swiss-Prot:

RBM38_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q9H0Z9
Family:
  • Belongs to the RBM38 family.:
    • Q9H0Z9
genes like me logo Genes that share domains with RBM38: view

Function for RBM38 Gene

Molecular function for RBM38 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein that specifically bind the 3-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
UniProtKB/Swiss-Prot Induction: By p53/TP53 family. Directly induced by p53/TP53, TP63/p63 and TP73/p73.

Gene Ontology (GO) - Molecular Function for RBM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003729 mRNA binding IEA --
GO:0003730 mRNA 3-UTR binding IDA 17050675
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM38: view

Phenotypes for RBM38 Gene

GenomeRNAi human phenotypes for RBM38:
genes like me logo Genes that share phenotypes with RBM38: view

miRNA for RBM38 Gene

miRTarBase miRNAs that target RBM38

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM38 Gene

Localization for RBM38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM38 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM38 Gene COMPARTMENTS Subcellular localization image for RBM38 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RBM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RBM38: view

Pathways for RBM38 Gene

SuperPathways for RBM38 Gene

No Data Available

Interacting Proteins for RBM38 Gene

Gene Ontology (GO) - Biological Process for RBM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA 17050675
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA 17050675
GO:0007049 cell cycle IEA --
GO:0007050 NOT cell cycle arrest IDA 17050675
genes like me logo Genes that share ontologies with RBM38: view

No data available for Pathways by source for RBM38 Gene

Transcripts for RBM38 Gene

Unigene Clusters for RBM38 Gene

RNA binding motif protein 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM38 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RBM38 Gene

GeneLoc Exon Structure for
RBM38
ECgene alternative splicing isoforms for
RBM38

Expression for RBM38 Gene

mRNA expression in normal human tissues for RBM38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBM38 Gene

This gene is overexpressed in Whole Blood (10.3) and Muscle - Skeletal (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM38 Gene

SOURCE GeneReport for Unigene cluster for RBM38 Gene Hs.236361

genes like me logo Genes that share expressions with RBM38: view

Orthologs for RBM38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
OneToMany
RBM38 36
  • 98.61 (n)
  • 98.15 (a)
RBM38 37
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RBM38 36
  • 92.47 (n)
  • 96.23 (a)
RBM38 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM38 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm38 36
  • 89.17 (n)
  • 95.36 (a)
Rbm38 16
Rbm38 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM38 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM38 37
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM38 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM38 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398603 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm38 36
  • 74.8 (n)
  • 78.4 (a)
Str.15196 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6474 36
zebrafish
(Danio rerio)
Actinopterygii rbm38 36
  • 68.95 (n)
  • 69.12 (a)
rbm38 37
  • 55 (a)
OneToOne
rnpc1 36
worm
(Caenorhabditis elegans)
Secernentea sup-12 37
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.15114 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10652 37
  • 43 (a)
OneToMany
Species with no ortholog for RBM38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM38 Gene

ENSEMBL:
Gene Tree for RBM38 (if available)
TreeFam:
Gene Tree for RBM38 (if available)

Paralogs for RBM38 Gene

Paralogs for RBM38 Gene

genes like me logo Genes that share paralogs with RBM38: view

Variants for RBM38 Gene

Sequence variations from dbSNP and Humsavar for RBM38 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs11021 -- 57,409,036(-) CCCAA(A/G)ACAGG utr-variant-3-prime
rs328491 -- 57,394,436(+) CCTGC(C/T)GGCTT intron-variant
rs328492 -- 57,394,641(+) GGAAT(C/G)TGTTT intron-variant
rs328493 -- 57,395,083(+) AGTGC(A/G)CAGGC intron-variant
rs328494 -- 57,395,994(+) TTCCT(C/T)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM38 Gene

Variant ID Type Subtype PubMed ID
nsv3424 CNV Insertion 18451855
nsv516617 CNV Loss 19592680
nsv912958 CNV Loss 21882294
dgv4582n71 CNV Loss 21882294
esv33591 CNV Loss 17666407
esv2722601 CNV Deletion 23290073
esv2722602 CNV Deletion 23290073
esv2722603 CNV Deletion 23290073
esv33697 CNV Gain 17666407
nsv517912 CNV Loss 19592680

Relevant External Links for RBM38 Gene

HapMap Linkage Disequilibrium report
RBM38

Disorders for RBM38 Gene

Relevant External Links for RBM38

Genetic Association Database (GAD)
RBM38
genes like me logo Genes that share disorders with RBM38: view

No data available for UniProtKB/Swiss-Prot for RBM38 Gene

Publications for RBM38 Gene

  1. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 49
  2. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 49
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. (PMID: 17050675) Shu L. … Chen X. (Genes Dev. 2006) 3 4
  5. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. (PMID: 19285943) Warzecha C.C. … Carstens R.P. (Mol. Cell 2009) 3 4

Products for RBM38 Gene

Sources for RBM38 Gene

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