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Aliases for RBM34 Gene

Aliases for RBM34 Gene

  • RNA Binding Motif Protein 34 2 3 5
  • RNA-Binding Motif Protein 34 4
  • KIAA0117 4

External Ids for RBM34 Gene

Previous GeneCards Identifiers for RBM34 Gene

  • GC01M231489
  • GC01M233361
  • GC01M235294
  • GC01M205743

Summaries for RBM34 Gene

Entrez Gene Summary for RBM34 Gene

  • This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

GeneCards Summary for RBM34 Gene

RBM34 (RNA Binding Motif Protein 34) is a Protein Coding gene. Diseases associated with RBM34 include Spherocytosis, Type 1. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

Gene Wiki entry for RBM34 Gene

Additional gene information for RBM34 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM34 Gene

Genomics for RBM34 Gene

Regulatory Elements for RBM34 Gene

Enhancers for RBM34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H235641 1.4 FANTOM5 Ensembl ENCODE 4.5 -481.0 -481049 2 KLF1 JUN KLF17 BATF ZIC2 FOSL1 ZFHX2 EGR1 FOXK2 POLR2A ARID4B ENSG00000273058 ENSG00000230325 HEATR1 RPS21P1 GNG4 LYST RBM34 LOC100131725
GH01H234840 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +318.6 318603 5 HDGF PKNOX1 ARNT SIN3A TCF12 ZNF121 GATA2 ZNF207 ATF7 RUNX3 IRF2BP2 ENSG00000228830 RBM34 RNY4P16 PIR44809
GH01H235295 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -135.4 -135379 2 HDGF PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A ZNF121 GATA2 FOS ARID4B RPS21P1 GGPS1 TOMM20 RBM34 RPL23AP23 GC01M235309
GH01H235304 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.1 -143.6 -143634 2 PKNOX1 FEZF1 ZNF121 GATA3 ZNF600 PRDM10 NR2F6 RCOR1 TCF7L2 RFX1 ARID4B GGPS1 RBM34 GC01M235309 RPL23AP23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM34 on UCSC Golden Path with GeneCards custom track

Promoters for RBM34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RBM34 Gene

235,131,183 bp from pter
235,161,616 bp from pter
30,434 bases
Minus strand

Genomic View for RBM34 Gene

Genes around RBM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM34 Gene

Proteins for RBM34 Gene

  • Protein details for RBM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 34
    Protein Accession:
    Secondary Accessions:
    • A8K8J7
    • Q8N2Z8
    • Q9H5A1

    Protein attributes for RBM34 Gene

    430 amino acids
    Molecular mass:
    48565 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH29451.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA07503.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF85051.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM34 Gene


neXtProt entry for RBM34 Gene

Post-translational modifications for RBM34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM34 Gene

No data available for DME Specific Peptides for RBM34 Gene

Domains & Families for RBM34 Gene

Gene Families for RBM34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM34 Gene

Suggested Antigen Peptide Sequences for RBM34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRM RBM34 family.
  • Belongs to the RRM RBM34 family.
genes like me logo Genes that share domains with RBM34: view

Function for RBM34 Gene

Phenotypes From GWAS Catalog for RBM34 Gene

Gene Ontology (GO) - Molecular Function for RBM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 22658674
genes like me logo Genes that share ontologies with RBM34: view

Phenotypes for RBM34 Gene

genes like me logo Genes that share phenotypes with RBM34: view

Animal Model Products

CRISPR Products

miRNA for RBM34 Gene

miRTarBase miRNAs that target RBM34

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RBM34
  • Applied Biological Materials Clones for RBM34
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM34 Gene

Localization for RBM34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM34 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM34 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with RBM34: view

Pathways & Interactions for RBM34 Gene

SuperPathways for RBM34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM34 Gene


No data available for Pathways by source and SIGNOR curated interactions for RBM34 Gene

Drugs & Compounds for RBM34 Gene

No Compound Related Data Available

Transcripts for RBM34 Gene

Unigene Clusters for RBM34 Gene

RNA binding motif protein 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RBM34
  • Applied Biological Materials Clones for RBM34
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RBM34 Gene

No ASD Table

Relevant External Links for RBM34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM34 Gene

This gene is overexpressed in Lung (52.7) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM34 Gene

Protein tissue co-expression partners for RBM34 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM34 Gene:


SOURCE GeneReport for Unigene cluster for RBM34 Gene:


Evidence on tissue expression from TISSUES for RBM34 Gene

  • Bone marrow(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RBM34: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM34 Gene

Orthologs for RBM34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBM34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM34 33 34
  • 99.07 (n)
(Canis familiaris)
Mammalia RBM34 33 34
  • 84.48 (n)
(Bos Taurus)
Mammalia RBM34 34
  • 79 (a)
(Mus musculus)
Mammalia Rbm34 33 16 34
  • 77.28 (n)
(Rattus norvegicus)
Mammalia Rbm34 33
  • 76.91 (n)
(Monodelphis domestica)
Mammalia RBM34 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia RBM34 34
  • 56 (a)
(Gallus gallus)
Aves RBM34 33 34
  • 60.63 (n)
(Anolis carolinensis)
Reptilia RBM34 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm34 33
  • 57.39 (n)
(Danio rerio)
Actinopterygii rbm34 33 34
  • 56.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12288 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea F11A10.7 34
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP12 34
  • 27 (a)
Species where no ortholog for RBM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM34 Gene

Gene Tree for RBM34 (if available)
Gene Tree for RBM34 (if available)

Paralogs for RBM34 Gene

No data available for Paralogs for RBM34 Gene

Variants for RBM34 Gene

Sequence variations from dbSNP and Humsavar for RBM34 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000012324 -- 235,144,002(+) TGACA(C/T)CTTGG intron-variant
rs1000081775 -- 235,145,766(+) TACAA(C/G)GTCAC intron-variant
rs1000149368 -- 235,144,219(+) AATCA(C/T)TATGC intron-variant
rs1000288295 -- 235,133,154(+) CTGAG(A/C)AACAT intron-variant
rs1000352419 -- 235,134,351(+) AGTCG(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM34 Gene

Variant ID Type Subtype PubMed ID
esv2670623 CNV deletion 23128226
esv2725296 CNV deletion 23290073
esv275126 CNV loss 21479260
esv3548744 CNV deletion 23714750
esv3578486 CNV loss 25503493
esv3891237 CNV loss 25118596
nsv508699 CNV deletion 20534489

Variation tolerance for RBM34 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM34 Gene

Disorders for RBM34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBM34 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spherocytosis, type 1
  • hereditary spherocytosis type 1
- elite association - COSMIC cancer census association via MalaCards
Search RBM34 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBM34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RBM34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM34 Gene

Publications for RBM34 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T … Kotani H (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  4. Microarray analysis of differentially expressed genes in cells resistant to HIV-1. (PMID: 15134903) Kartvelishvili A … Simm M (Immunology letters 2004) 2 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RBM34 Gene

  • Addgene plasmids for RBM34

Sources for RBM34 Gene

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