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Aliases for RBM34 Gene

Aliases for RBM34 Gene

  • RNA Binding Motif Protein 34 2 3 5
  • RNA-Binding Motif Protein 34 4
  • KIAA0117 4

External Ids for RBM34 Gene

Previous GeneCards Identifiers for RBM34 Gene

  • GC01M231489
  • GC01M233361
  • GC01M235294
  • GC01M205743

Summaries for RBM34 Gene

Entrez Gene Summary for RBM34 Gene

  • This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

GeneCards Summary for RBM34 Gene

RBM34 (RNA Binding Motif Protein 34) is a Protein Coding gene. Diseases associated with RBM34 include Spherocytosis, Type 1. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

Gene Wiki entry for RBM34 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM34 Gene

Genomics for RBM34 Gene

Regulatory Elements for RBM34 Gene

Enhancers for RBM34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G235126 1.2 ENCODE 9.5 +32.6 32632 4.6 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 RPS21P1 IRF2BP2 LDHAP2 LYST TARBP1 RBM34 GGPS1 ARID4B TOMM20 GC01P235131
GH01G234840 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +318.6 318603 5.6 MLX DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 GGPS1 RPS21P1 IRF2BP2 ENSG00000228830 GNG4 TOMM20 RBM34 RNY4P16 PIR44809
GH01G235641 1.4 FANTOM5 Ensembl ENCODE 4.5 -481.0 -481049 2.1 KLF1 JUN KLF17 RBBP5 ZIC2 FOSL1 ZFHX2 EGR1 FOXK2 POLR2A GNG4 ARID4B LYST RBM34 LOC100131725
GH01G235295 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -135.4 -135379 2.8 HDGF PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B SIN3A ZNF121 GATA2 ARID4B GGPS1 TOMM20 RBM34 RPL23AP23 GC01M235309
GH01G235304 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.1 -143.6 -143634 2.3 CTCF PKNOX1 FOXA2 FEZF1 ZNF121 GATA3 ZNF600 PRDM10 NR2F6 FOS ARID4B GGPS1 RBM34 GC01M235309 RPL23AP23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM34 on UCSC Golden Path with GeneCards custom track

Promoters for RBM34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022224 416 1601 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1

Genomic Location for RBM34 Gene

Chromosome:
1
Start:
235,131,183 bp from pter
End:
235,161,616 bp from pter
Size:
30,434 bases
Orientation:
Minus strand

Genomic View for RBM34 Gene

Genes around RBM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM34 Gene

Proteins for RBM34 Gene

  • Protein details for RBM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42696-RBM34_HUMAN
    Recommended name:
    RNA-binding protein 34
    Protein Accession:
    P42696
    Secondary Accessions:
    • A8K8J7
    • Q8N2Z8
    • Q9H5A1

    Protein attributes for RBM34 Gene

    Size:
    430 amino acids
    Molecular mass:
    48565 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29451.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA07503.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF85051.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM34 Gene

Post-translational modifications for RBM34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM34 Gene

No data available for DME Specific Peptides for RBM34 Gene

Domains & Families for RBM34 Gene

Gene Families for RBM34 Gene

Suggested Antigen Peptide Sequences for RBM34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42696

UniProtKB/Swiss-Prot:

RBM34_HUMAN :
  • Belongs to the RRM RBM34 family.
Family:
  • Belongs to the RRM RBM34 family.
genes like me logo Genes that share domains with RBM34: view

Function for RBM34 Gene

Gene Ontology (GO) - Molecular Function for RBM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
genes like me logo Genes that share ontologies with RBM34: view

Phenotypes for RBM34 Gene

genes like me logo Genes that share phenotypes with RBM34: view

Animal Model Products

CRISPR Products

miRNA for RBM34 Gene

miRTarBase miRNAs that target RBM34

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RBM34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM34 Gene

Localization for RBM34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM34 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM34 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RBM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with RBM34: view

Pathways & Interactions for RBM34 Gene

SuperPathways for RBM34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM34 Gene

Drugs & Compounds for RBM34 Gene

No Compound Related Data Available

Transcripts for RBM34 Gene

Unigene Clusters for RBM34 Gene

RNA binding motif protein 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RBM34

Alternative Splicing Database (ASD) splice patterns (SP) for RBM34 Gene

No ASD Table

Relevant External Links for RBM34 Gene

GeneLoc Exon Structure for
RBM34
ECgene alternative splicing isoforms for
RBM34

Expression for RBM34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM34 Gene

This gene is overexpressed in Lung (52.7) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM34 Gene



Protein tissue co-expression partners for RBM34 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM34 Gene:

RBM34

SOURCE GeneReport for Unigene cluster for RBM34 Gene:

Hs.535224

Evidence on tissue expression from TISSUES for RBM34 Gene

  • Bone marrow(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RBM34: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM34 Gene

Orthologs for RBM34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBM34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM34 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia RBM34 34 35
  • 84.48 (n)
cow
(Bos Taurus)
Mammalia RBM34 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm34 34 16 35
  • 77.28 (n)
rat
(Rattus norvegicus)
Mammalia Rbm34 34
  • 76.91 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM34 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM34 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM34 34 35
  • 60.63 (n)
lizard
(Anolis carolinensis)
Reptilia RBM34 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm34 34
  • 57.39 (n)
zebrafish
(Danio rerio)
Actinopterygii rbm34 34 35
  • 56.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12288 35
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11A10.7 35
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP12 35
  • 27 (a)
OneToOne
Species where no ortholog for RBM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM34 Gene

ENSEMBL:
Gene Tree for RBM34 (if available)
TreeFam:
Gene Tree for RBM34 (if available)

Paralogs for RBM34 Gene

No data available for Paralogs for RBM34 Gene

Variants for RBM34 Gene

Sequence variations from dbSNP and Humsavar for RBM34 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000012324 -- 235,144,002(+) TGACA(C/T)CTTGG intron-variant
rs1000081775 -- 235,145,766(+) TACAA(C/G)GTCAC intron-variant
rs1000149368 -- 235,144,219(+) AATCA(C/T)TATGC intron-variant
rs1000288295 -- 235,133,154(+) CTGAG(A/C)AACAT intron-variant
rs1000352419 -- 235,134,351(+) AGTCG(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM34 Gene

Variant ID Type Subtype PubMed ID
esv2670623 CNV deletion 23128226
esv2725296 CNV deletion 23290073
esv275126 CNV loss 21479260
esv3548744 CNV deletion 23714750
esv3578486 CNV loss 25503493
esv3891237 CNV loss 25118596
nsv508699 CNV deletion 20534489

Variation tolerance for RBM34 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM34 Gene

Disorders for RBM34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBM34 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spherocytosis, type 1
  • hereditary spherocytosis type 1
- elite association - COSMIC cancer census association via MalaCards
Search RBM34 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBM34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM34
genes like me logo Genes that share disorders with RBM34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM34 Gene

Publications for RBM34 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Microarray analysis of differentially expressed genes in cells resistant to HIV-1. (PMID: 15134903) Kartvelishvili A. … Simm M. (Immunol. Lett. 2004) 2 3 64

Products for RBM34 Gene

  • Addgene plasmids for RBM34

Sources for RBM34 Gene

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