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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBM34 Gene

protein-coding   GIFtS: 49
GCID: GC01M235294

RNA binding motif protein 34

 Explore 1 disease affiliated with
RBM34 via our new
 Human Malady Compendium 
Biological research products
for RBM34
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RNA Binding Motif Protein 341 2
KIAA01171 3
RNA-Binding Motif Protein 342 3
RNA-Binding Protein 342

External Ids:    HGNC: 289651   Entrez Gene: 230292   Ensembl: ENSG000001887397   UniProtKB: P426963   
ORGUL members:         
NONCODE:n408007    

Export aliases for RBM34 gene to outside databases

Previous GC identifers: GC01M231489 GC01M233361 GC01M205743


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for RBM34


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBM34 gene promoter:
         HOXA9   HOXA9B   POU2F1   FOXJ2 (long isoform)   POU2F1a   FOXO1a   STAT3   Meis-1a   FOXO1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM34 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBM34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.3   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42.3

RBM34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM34 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M235294:  view genomic region     (about GC identifiers)

Start:
235,294,498 bp from pter      End:
235,324,772 bp from pter
Size:
30,275 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBM34_HUMAN, P42696 (See protein sequence)
Recommended Name: RNA-binding protein 34  
Size: 430 amino acids; 48565 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAH29451.1; Type=Erroneous initiation; Sequence=BAA07503.1; Type=Erroneous initiation;
Sequence=BAF85051.1; Type=Erroneous initiation;
Secondary accessions: A8K8J7 Q8N2Z8 Q9H5A1
Alternative splicing: 2 isoforms:  P42696-1   P42696-2   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for RBM34: NX_P42696

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P42696

  • RBM34 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001155005.1  NP_055829.2  

    ENSEMBL proteins: 
     ENSP00000386226   ENSP00000400000   ENSP00000420236   ENSP00000413409   ENSP00000355565  

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    Novus Biologicals RBM34 Protein
    Novus Biologicals RBM34 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RBM34

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--


    RBM34 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RBM34


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RBM34 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P42696

    ProtoNet protein and cluster: P42696

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM34_HUMAN, P42696
    Similarity: Belongs to the RRM RBM34 family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    OriGene 3'-UTR Clone (see all 2): RBM34
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--


    RBM34 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RBM34:
     G0/1 arrest  Increased G1 DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for RBM34 (P426963 ENSP000003555654) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    CLN3Q132863I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=1 
    NSMAFQ926363I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBM34
    Search CenterWatch for drugs/clinical trials and news about RBM34 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RBM34 gene (2 alternative transcripts): 
    NM_001161533.1  NM_015014.2  

    Unigene Cluster for RBM34:

    RNA binding motif protein 34
    Hs.535224  [show with all ESTs]
    Unigene Representative Sequence: NM_015014
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000408888(uc001hwn.3 uc001hwo.3 uc010pxp.1) ENST00000495224
    ENST00000447801 ENST00000474086 ENST00000476261 ENST00000468751 ENST00000429912
    ENST00000475960 ENST00000486751 ENST00000485019 ENST00000366606

    miRNA
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    OriGene 3'-UTR Clone (see all 2): RBM34
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM34 (see all 7)
    OriGene shRNA RFP: RBM34
    OriGene siRNA: RBM34
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBM34
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM34 (see all 5)
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    Additional cDNA sequence: 

    AK292362.1 BC029451.1 D38491.1 NR_027762.1 

    18 DOTS entries:

    DT.315604  DT.100823464  DT.92433236  DT.100696358  DT.95198870  DT.75186254  DT.95089620  DT.121438660 
    DT.91666783  DT.95089619  DT.100844666  DT.452426  DT.95089630  DT.92037159  DT.100823448  DT.75127825 
    DT.92433237  DT.95096479 

    24/198 AceView cDNA sequences (see all 198):

    AI383138 AI342592 BQ026989 AI858562 AA743611 AA447551 CR615831 BU632835 
    CB115829 CB150476 D38491 CB142607 BQ924877 BU076256 CB116435 AI476616 
    AU123670 AI343363 BQ446327 BF513421 NM_015014 BU609087 AI937399 CR609536 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBM34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGTTCTGTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RBM34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBM34

    SOURCE GeneReport for Unigene cluster: Hs.535224
        SABiosciences Custom PCR Arrays for RBM34
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM34
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBM34 gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm341 , 5 RNA binding motif protein 341, 5 77.52(n)1
    71.43(a)1
      8 (74.64 cM)5
    522021  NM_172762.21  NP_766350.21 
     1269471755 
    chicken
    (Gallus gallus)
    Aves RBM341 RNA binding motif protein 34 61.16(n)
    56.91(a)
      426311  XM_423974.3  XP_423974.3 
    lizard
    (Anolis carolinensis)
    Reptilia RBM346
    --
    47(a)
    1 ↔ 1
    1(219636191-219649139)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD328749.12   -- 70.57(n)    CD328749.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rbm341 RNA binding motif protein 34 54.73(n)
    50.93(a)
      436655  NM_001002382.1  NP_001002382.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG122886
    --
    20(a)
    1 ↔ 1
    2L(16900535-16902189)
    worm
    (Caenorhabditis elegans)
    Secernentea F11A10.71 Protein F11A10.7 44.66(n)
    33.01(a)
      178148  NM_069890.5  NP_502291.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOP12(YOL041C)4
    NOP121
    Nucleolar protein involved in pre-25S rRNA processing more4
    Nop12p1
    46.3(n)1
    33.61(a)1
      15(252646-251267)4
    8541161, 4  NP_014601.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G468401 RNA recognition motif-containing protein 47.14(n)
    37.47(a)
      834728  NM_124055.3  NP_199496.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08543001 hypothetical protein 46.88(n)
    38.62(a)
      4334825  NM_001058472.1  NP_001051937.1 


    ENSEMBL Gene Tree for RBM34 (if available)
    TreeFam Gene Tree for RBM34 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 NCBI SNPs in RBM34 are shown (see all 474    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930530091,2
    --235294425(+) GAAGCA/GACATC 2 -- int10--------
    rs1473675991,2
    --235294493(+) ACACAC/TGGAGT 2 -- int10--------
    rs775179311,2
    C,F,--235294537(+) GAAAGG/CAGGCT 2 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.05NA 120
    rs1856620251,2
    --235294636(+) GGCCAA/TCATGG 2 -- nc-transcript-variantut310--------
    rs1905694041,2
    --235294737(+) AGAAGC/TGCTTG 2 -- ut31 nc-transcript-variant0--------
    rs1145150101,2
    F,--235294804(+) GGAGAC/TAACAG 2 -- nc-transcript-variantut311Minor allele frequency- T:0.02WA 118
    rs1810316061,2
    --235294814(+) GCCAAA/TCTCCA 2 -- nc-transcript-variantut310--------
    rs1837886221,2
    --235295039(+) CTGTTC/TTCTCT 3 K E nc-transcript-variantmis10--------
    rs1881312741,2
    --235295086(+) TCTTCA/GTTTTA 3 T M nc-transcript-variantmis10--------
    rs731127961,2
    C,F,--235295214(+) TGTTGT/CTTAAA 3 /K nc-transcript-variantsyn12Minor allele frequency- C:0.00WA EU 1277

    HapMap Linkage Disequilibrium report for RBM34 (235294498 - 235324772 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RBM34: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RBM34 for disorders           About GeneDecksing

    1 disease for RBM34:    About MalaCards
    malaria


    Export disorders for RBM34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBM34 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RBM34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T....Kotani H. (1995)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Microarray analysis of differentially expressed genes in cells resistant to HIV-1. (PubMed id 15134903)1, 3 Kartvelishvili A....Simm M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    7. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23029 HGNC: 28965 AceView: KIAA0117 Ensembl:ENSG00000188739 euGenes: HUgn23029
    ECgene: RBM34 H-InvDB: RBM34

    (According to HUGE)
    About This Section
    HUGE: KIAA0117

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBM34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RBM34 gene:
    Search GeneIP for patents involving RBM34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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