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Aliases for RBM33 Gene

Aliases for RBM33 Gene

  • RNA Binding Motif Protein 33 2 3 5
  • RNA-Binding Motif Protein 33 3 4
  • Proline-Rich Protein 8 3 4
  • Proline Rich 8 2 3
  • PRR8 3 4
  • Hypothetical Protein MGC20460 3

External Ids for RBM33 Gene

Previous HGNC Symbols for RBM33 Gene

  • PRR8

Previous GeneCards Identifiers for RBM33 Gene

  • GC07P155039
  • GC07P155232
  • GC07P155133
  • GC07P155437
  • GC07P149167

Summaries for RBM33 Gene

GeneCards Summary for RBM33 Gene

RBM33 (RNA Binding Motif Protein 33) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

Gene Wiki entry for RBM33 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM33 Gene

Genomics for RBM33 Gene

Regulatory Elements for RBM33 Gene

Promoters for RBM33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM33 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM33 Gene

Chromosome:
7
Start:
155,644,451 bp from pter
End:
155,781,485 bp from pter
Size:
137,035 bases
Orientation:
Plus strand

Genomic View for RBM33 Gene

Genes around RBM33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM33 Gene

Proteins for RBM33 Gene

  • Protein details for RBM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EV2-RBM33_HUMAN
    Recommended name:
    RNA-binding protein 33
    Protein Accession:
    Q96EV2
    Secondary Accessions:
    • A4D244
    • B5MC24
    • Q52LF5
    • Q75LN9
    • Q75ML5
    • Q9NSV0

    Protein attributes for RBM33 Gene

    Size:
    1170 amino acids
    Molecular mass:
    129986 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH93947.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93949.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS01989.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAS02026.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAS07551.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB70894.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAL23911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAL23912.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX04539.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM33 Gene

Proteomics data for RBM33 Gene at MOPED

Post-translational modifications for RBM33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM33 Gene

Domains & Families for RBM33 Gene

Gene Families for RBM33 Gene

Protein Domains for RBM33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RBM33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EV2

UniProtKB/Swiss-Prot:

RBM33_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBM33: view

Function for RBM33 Gene

Gene Ontology (GO) - Molecular Function for RBM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM33: view
genes like me logo Genes that share phenotypes with RBM33: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM33 Gene

Localization for RBM33 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM33 Gene COMPARTMENTS Subcellular localization image for RBM33 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM33 Gene

Pathways & Interactions for RBM33 Gene

SuperPathways for RBM33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM33 Gene

Drugs & Compounds for RBM33 Gene

No Compound Related Data Available

Transcripts for RBM33 Gene

Unigene Clusters for RBM33 Gene

RNA binding motif protein 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for RBM33 Gene

GeneLoc Exon Structure for
RBM33
ECgene alternative splicing isoforms for
RBM33

Expression for RBM33 Gene

mRNA expression in normal human tissues for RBM33 Gene

Protein differential expression in normal tissues from HIPED for RBM33 Gene

This gene is overexpressed in Cervix (21.0), Peripheral blood mononuclear cells (13.1), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM33 Gene



SOURCE GeneReport for Unigene cluster for RBM33 Gene Hs.591815

genes like me logo Genes that share expression patterns with RBM33: view

Protein tissue co-expression partners for RBM33 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM33 Gene

Orthologs for RBM33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBM33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM33 35
  • 98.85 (n)
  • 98.44 (a)
RBM33 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM33 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM33 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM33 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm33 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM33 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM33 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM33 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RBM33 (1 of 2) 36
  • 39 (a)
OneToMany
RBM33 (2 of 2) 36
  • 24 (a)
OneToMany
Species with no ortholog for RBM33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBM33 Gene

ENSEMBL:
Gene Tree for RBM33 (if available)
TreeFam:
Gene Tree for RBM33 (if available)

Paralogs for RBM33 Gene

No data available for Paralogs for RBM33 Gene

Variants for RBM33 Gene

Sequence variations from dbSNP and Humsavar for RBM33 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3735576 - 155,738,386(+) CACAC(A/G)CACAG reference, missense
rs1109626 -- 155,680,158(-) TATTC(C/T)ATAAG intron-variant
rs1006524 -- 155,779,312(+) TTGAC(C/T)GATAG utr-variant-3-prime
rs1006525 -- 155,779,507(+) ATTCT(A/C)CAAAG utr-variant-3-prime
rs984543 -- 155,652,359(-) TTTAA(C/T)GGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM33 Gene

Variant ID Type Subtype PubMed ID
esv274974 CNV Loss 21479260
esv2735590 CNV Deletion 23290073
nsv365283 CNV Loss 16902084
esv997138 CNV Insertion 20482838
nsv509227 CNV Insertion 20534489
nsv889560 CNV Loss 21882294
dgv7559n71 CNV Loss 21882294

Variation tolerance for RBM33 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.65; 82.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM33 Gene

HapMap Linkage Disequilibrium report
RBM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM33 Gene

Disorders for RBM33 Gene

Relevant External Links for RBM33

Genetic Association Database (GAD)
RBM33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM33

No disorders were found for RBM33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM33 Gene

Publications for RBM33 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells. (PMID: 24515614) Zhang Y. … Wei S.J. (Protein Cell 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3

Products for RBM33 Gene

Sources for RBM33 Gene

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