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Aliases for RBM33 Gene

Aliases for RBM33 Gene

  • RNA Binding Motif Protein 33 2 3 5
  • Proline-Rich Protein 8 3 4
  • Proline Rich 8 2 3
  • PRR8 3 4
  • Hypothetical Protein MGC20460 3
  • RNA-Binding Motif Protein 33 4
  • RNA-Binding Protein 33 3

External Ids for RBM33 Gene

Previous HGNC Symbols for RBM33 Gene

  • PRR8

Previous GeneCards Identifiers for RBM33 Gene

  • GC07P155039
  • GC07P155232
  • GC07P155133
  • GC07P155437
  • GC07P149167

Summaries for RBM33 Gene

GeneCards Summary for RBM33 Gene

RBM33 (RNA Binding Motif Protein 33) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

Gene Wiki entry for RBM33 Gene

Additional gene information for RBM33 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM33 Gene

Genomics for RBM33 Gene

Regulatory Elements for RBM33 Gene

Enhancers for RBM33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H155917 1.3 Ensembl ENCODE 53.5 +274.3 274260 3.3 PKNOX1 FOXA2 MLX YBX1 DMAP1 ZNF2 YY1 ZNF207 ZNF548 FOS PAXIP1-AS2 RBM33 PAXIP1 ENSG00000273183 PAXIP1-AS1 RNF32 LOC389602 GC07M155822
GH07H155643 1.1 ENCODE 35.5 +0.7 656 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 RBM33 PAXIP1 PAXIP1-AS2 ENSG00000273183 LOC100506302
GH07H155203 1.7 Ensembl ENCODE dbSUPER 12 -437.7 -437667 6 HDGF PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF766 CBX5 PAXIP1-AS2 PAXIP1 ENSG00000227365 LOC105375589 BLACE RBM33 LOC105375580 ENSG00000273183 PAXIP1-AS1 LOC105375586
GH07H155295 1.3 ENCODE dbSUPER 12 -345.7 -345677 6.1 HDGF FOXA2 PKNOX1 ARNT SIN3A ZNF2 YY1 CBX5 ZNF207 FOS LOC105375591 RBM33 PAXIP1 GC07P155307
GH07H154675 1.3 ENCODE dbSUPER 12 -968.0 -968035 1.3 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 RBM33 PAXIP1 GC07P154680 LOC105375581
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM33 on UCSC Golden Path with GeneCards custom track

Promoters for RBM33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000220095 449 2601 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Locations for RBM33 Gene

Genomic Locations for RBM33 Gene
chr7:155,644,451-155,781,485
(GRCh38/hg38)
Size:
137,035 bases
Orientation:
Plus strand
chr7:155,437,145-155,574,179
(GRCh37/hg19)

Genomic View for RBM33 Gene

Genes around RBM33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM33 Gene

Proteins for RBM33 Gene

  • Protein details for RBM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EV2-RBM33_HUMAN
    Recommended name:
    RNA-binding protein 33
    Protein Accession:
    Q96EV2
    Secondary Accessions:
    • A4D244
    • B5MC24
    • Q52LF5
    • Q75LN9
    • Q75ML5
    • Q9NSV0

    Protein attributes for RBM33 Gene

    Size:
    1170 amino acids
    Molecular mass:
    129986 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH93947.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93949.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS01989.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAS02026.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAS07551.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB70894.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAL23911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAL23912.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX04539.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM33 Gene

Post-translational modifications for RBM33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM33 Gene

Domains & Families for RBM33 Gene

Gene Families for RBM33 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RBM33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM33: view

No data available for UniProtKB/Swiss-Prot for RBM33 Gene

Function for RBM33 Gene

Gene Ontology (GO) - Molecular Function for RBM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 22658674
genes like me logo Genes that share ontologies with RBM33: view
genes like me logo Genes that share phenotypes with RBM33: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM33 Gene

Localization for RBM33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM33 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM33 Gene

Pathways & Interactions for RBM33 Gene

SuperPathways for RBM33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM33 Gene

Drugs & Compounds for RBM33 Gene

No Compound Related Data Available

Transcripts for RBM33 Gene

Unigene Clusters for RBM33 Gene

RNA binding motif protein 33:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for RBM33 Gene

GeneLoc Exon Structure for
RBM33
ECgene alternative splicing isoforms for
RBM33

Expression for RBM33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM33 Gene

Protein differential expression in normal tissues from HIPED for RBM33 Gene

This gene is overexpressed in Cervix (21.0), Peripheral blood mononuclear cells (13.1), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM33 Gene



Protein tissue co-expression partners for RBM33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM33 Gene:

RBM33

SOURCE GeneReport for Unigene cluster for RBM33 Gene:

Hs.591815

Evidence on tissue expression from TISSUES for RBM33 Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with RBM33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM33 Gene

Orthologs for RBM33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBM33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM33 33 34
  • 98.85 (n)
dog
(Canis familiaris)
Mammalia RBM33 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm33 34
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM33 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM33 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM33 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM33 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM33 34
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RBM33 (1 of 2) 34
  • 39 (a)
OneToMany
RBM33 (2 of 2) 34
  • 24 (a)
OneToMany
Species where no ortholog for RBM33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBM33 Gene

ENSEMBL:
Gene Tree for RBM33 (if available)
TreeFam:
Gene Tree for RBM33 (if available)

Paralogs for RBM33 Gene

No data available for Paralogs for RBM33 Gene

Variants for RBM33 Gene

Sequence variations from dbSNP and Humsavar for RBM33 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000001590 -- 155,726,821(+) ACTAT(A/G)ATGGA intron-variant
rs1000073813 -- 155,672,669(+) GAGCC(C/T)GGGAG intron-variant
rs1000079528 -- 155,771,791(+) CAGTG(G/T)TATGA intron-variant
rs1000088544 -- 155,666,883(+) TAATC(-/T)TTTTT intron-variant
rs1000142149 -- 155,671,231(+) ATTTG(A/T)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM33 Gene

Variant ID Type Subtype PubMed ID
nsv951661 CNV duplication 24416366
nsv509227 CNV insertion 20534489
nsv480477 CNV novel sequence insertion 20440878
nsv365283 CNV deletion 16902084
nsv1140870 CNV deletion 24896259
nsv1134906 CNV tandem duplication 24896259
nsv1109931 CNV deletion 24896259
nsv1033092 CNV loss 25217958
nsv1032585 CNV gain 25217958
nsv1021843 CNV loss 25217958
esv997138 CNV insertion 20482838
esv3615635 CNV loss 21293372
esv3576492 CNV gain 25503493
esv3572346 CNV loss 25503493
esv274974 CNV loss 21479260
esv2735590 CNV deletion 23290073
dgv6767n100 CNV gain 25217958

Variation tolerance for RBM33 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.65; 82.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM33 Gene

Disorders for RBM33 Gene

Relevant External Links for RBM33

Genetic Association Database (GAD)
RBM33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM33

No disorders were found for RBM33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM33 Gene

Publications for RBM33 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RBM33 Gene

Sources for RBM33 Gene

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